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Leptomeningeal carcinomatosis

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https://www.readbyqxmd.com/read/29567868/-surgical-resection-of-metastatic-brain-tumors-risk-of-local-recurrence-and-leptomeningeal-dissemination-and-implications-for-individualized-treatment
#1
Yoko Nakasu, Koichi Mitsuya, Shoichi Deguchi, Nakamasa Hayashi, Hideyuki Harada
Metastatic brain tumors are important complications in the overall management of cancers. We sought to determine the risk of local recurrence and leptomeningeal carcinomatosis(LC)in patients treated with surgical resection and adjuvant radiation therapy. We retrospectively reviewed 173 consecutive patients with metastatic brain tumors managed by surgical resection between 2002 and 2015 in a single institution. Eighty-seven percent of the patients underwent postoperative adjuvant radiotherapy. The median overall survival from surgery was 9...
March 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29537406/leptomeningeal-carcinomatosis-easy-to-miss
#2
A Sekhar, B Corbo, K Das, S Biswas
Leptomeningeal carcinomatosis is a devastating condition with very poor prognosis. With advances in cancer treatment leading to improved survival in solid tumours, the incidence of ante-mortem diagnosis of leptomeningeal carcinomatosis is likely to rise. Without a high index of suspicion and appropriate imaging the diagnosis can be missed. We report two cases of leptomeningeal carcinomatosis secondary to metastatic breast disease with varied clinical presentation where the diagnosis was initially missed.
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29526074/erratum-to-retrospective-analysis-of-cerebrospinal-fluid-profiles-in-228-patients-with-leptomeningeal-carcinomatosis-differences-according-to-the-sampling-site-symptoms-and-systemic-factors-by-shim-y-et-al-j-korean-neurosurg-soc-59-570-576-2016
#3
https://www.readbyqxmd.com/read/29515424/intracranial-leptomeningeal-carcinomatosis-a-diagnostic-study-with-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#4
Susanna Nuvoli, Silvia Contu, Bi Llie Joy Pung, Patrizia Solinas, Giuseppe Madeddu, Angela Spanu
Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) was also employed in doubtful cases. We retrospectively described 4 suspected LC cases with uncertain or undetectable MRI and initially negative CSF cytology. Whole-body (WB) and brain18 F-FDG PET/computed tomography (CT) were used, the latter showing intracranial tracer uptakes suspected for LC in 3/4 cases...
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29496285/leptomeningeal-carcinomatosis-in-a-patient-with-clinical-stage-iii-lung-adenocarcinoma-and-sudden-neurological-impairment
#5
Jose Carlos Benítez, Romà Bastús, Luis Luizaga, Luis Cirera, Marc Campayo
No abstract text is available yet for this article.
February 26, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29463236/rapid-symptomatic-relief-of-her2-positive-gastric-cancer-leptomeningeal-carcinomatosis-with-lapatinib-trastuzumab-and-capecitabine-a-case-report
#6
Xiao-Dong Jiao, Chunming Ding, Yuan-Sheng Zang, Guanzhen Yu
BACKGROUND: Gastric cancer patients with widespread metastasis, especially meningeal metastases, have an extremely prognosis and limited therapeutic choices. CASE PRESENTATION: We reported the case of a 39-year-old male patient with HER2-positive gastric cancer with bone and meningeal metastases. He presented with multiple bone metastases and received 3 cycles of docetaxel plus S1. However, he complained with headache and imaging examinations revealed leptomeningeal carcinomatosis...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29375749/leptomeningeal-metastases-originated-from-esophagogastric-junction-gastric-cancer-a-brief-report-of-two-cases
#7
Panteleimon Kountourakis, Demetris Papamichael, Haris Haralambous, Michael Michael, Georgios Nakos, Sylvia Lazaridou, Eleni Fotiou, Vassilios Vassiliou, Demetrios Andreopoulos
Leptomeningeal carcinomatosis is a very rare manifestation in patients diagnosed with esophagogastric junction and gastric cancer. Its prognosis is ominous and therapy outcomes are disappointing. Herein, we present two patients; one initially diagnosed with gastric cancer and leptomeningeal carcinomatosis but no other evidence of metastatic disease and the other one initially diagnosed with esophagogastric junction cancer, who recurred solitary with leptomeningeal seedings several years after the initial diagnosis and treatment...
January 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29305723/image-guided-ommaya-reservoir-insertion-for-intraventricular-chemotherapy-a-retrospective-series
#8
Jonathan C Lau, Suzanne E Kosteniuk, David R Macdonald, Joseph F Megyesi
BACKGROUND: Ayub Ommaya proposed a surgical technique for subcutaneous reservoir and pump placement in 1963 to allow access to intraventricular cerebrospinal fluid (CSF). Currently, the most common indication for Ommaya reservoir insertion (ORI) in adults is for patients with hematologic or leptomeningeal disorders requiring repeated injection of chemotherapy into the CSF space. Historically, the intraventricular catheter has been inserted blindly based on anatomical landmarks. The purpose of this study was to examine short-term complication rates with ORI with image guidance (IG) and without image guidance (non-IG)...
March 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29221687/leptomeningeal-carcinomatosis-in-colorectal-cancer-the-mayo-clinic-experience
#9
Gretchen Taylor, Nina Karlin, Thorvardur R Halfdanarson, Kyle Coppola, Axel Grothey
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon form of metastatic disease in many cancers. There remains a paucity of literature with regard to the course and management of LM in colorectal cancers (CRCs). The aim of this study was to estimate the incidence of LM in patients with CRC seen at our institution over a 15-year period, and to describe the clinical course and outcome of these cases. METHODS: LM in CRC primary cases between 2000 and 2014 were identified in the Mayo Clinic databases...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29188211/response-of-leptomeningeal-dissemination-of-anaplastic-glioma-to-temozolomide-experience-of-two-cases
#10
Jin Woo Bae, Eun Kyung Hong, Ho-Shin Gwak
The incidence of leptomeningeal dissemination (LMD) of anaplastic glioma has been increasing. LMD can be observed at the time of initial presentation or the time of recurrence. As a result of both rarity and unusual presentation, a standard therapy has not yet been suggested. In contrast to leptomeningeal carcinomatosis for systemic solid cancers, a relatively prolonged survival is observed in some patients with LMD of anaplastic gliomas. Treatment modalities include whole craniospinal irradiation, intra-cerebrospinal fluid (CSF) chemotherapy, and systemic chemotherapy...
October 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29163342/novel-anterior-brainstem-magnetic-resonance-imaging-findings-in-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis
#11
Chun-Yu Cheng, Chia-Yu Hsu, Yuan-Hsiung Tsai, Kuang-Lin Lin, Cih-En Huang, Yi-Hong Fan, Shy-Chyi Chin, Yen-Chu Huang
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29159778/risk-of-leptomeningeal-carcinomatosis-in-patients-with-brain-metastases-treated-with-stereotactic-radiosurgery
#12
Rosaline Ma, Morgan Levy, Bin Gui, Shou-En Lu, Venkat Narra, Sharad Goyal, Shabbar Danish, Simon Hanft, Atif J Khan, Jyoti Malhotra, Sabin Motwani, Salma K Jabbour
There is limited available literature examining factors that predispose patients to the development of LMC after stereotactic radiosurgery (SRS) for brain metastases. We sought to evaluate risk factors that may predispose patients to LMC after SRS treatment in this case-control study of patients with brain metastases who underwent single-fraction SRS between 2011 and 2016. Demographic and clinical information were collected retrospectively for 19 LMC cases and 30 controls out of 413 screened patients with brain metastases...
January 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28913746/leptomeningeal-carcinomatosis-associated-with-gall-bladder-carcinoma-a-case-report-and-review-of-literature
#13
Talal H Khan, Manik Veer, Mohammad Bilal, Sheilah Curran-Melendez, Prashant M Jani, Gregory S Long
No abstract text is available yet for this article.
September 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28904471/leptomeningeal-carcinomatosis-presenting-as-cauda-equina-syndrome
#14
Bhagyadhan A Patel, Rahul T Chakor, Swaleha Nadaf, Kaumil V Kothari
No abstract text is available yet for this article.
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28881814/diagnostic-and-prognostic-values-of-cerebrospinal-fluid-cyfra-21-1-in-patients-with-leptomeningeal-carcinomatosis
#15
Jae-Won Hyun, Ji Hyun Park, Boo Gil Kang, Eun Young Park, Boram Park, Jungnam Joo, Jong Kuk Kim, Su-Hyun Kim, Jee Hyang Jeong, Hyang Woon Lee, Kee Duk Park, Kyung Gyu Choi, Sang-Hyun Hwang, Ho-Shin Gwak, Ho Jin Kim
OBJECTIVES: To investigate the diagnostic and prognostic values of cerebrospinal fluid (CSF) CYFRA 21-1 in patients with leptomeningeal carcinomatosis (LMC). METHODS: Concentration of CSF CYFRA 21-1 was detected using electro-chemiluminescent immunoassay. The difference in level of CYFRA 21-1 between 61 patients with LMC and 200 patients with other neurological disease was evaluated, and diagnostic performance of CSF CYFRA 21-1 was investigated. In LMC patients treated with ventriculo-lumbar perfusion (VLP) chemotherapy, prognostic performance of CSF CYFRA 21-1 was evaluated...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881161/leptomeningeal-carcinomatosis-from-gastric-cancer-successfully-treated-by-the-intrathecal-methotrexate-plus-temozolomide-and-simultaneous-radiotherapy-case-report-and-literatures-review
#16
Yangyang Liu
Leptomeningeal carcinomatosis (LMC) from gastrointestinal cancer is rare. A 56-year-old man with complaint of upper abdominal pain exhibited adenocarcinoma upon histopathologic examination of biopsy specimens. At the end of adjuvant chemotherapy, the patient was affected by hearing loss. Malignant cells were observed by cerebrospinal fluid (CSF) cytology. Therefore, the patient received intrathecal methotrexate and oral temozolomide chemotherapy and radiotherapy. The progress-free survival was approximately 11 months...
October 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28790264/-a-case-of-lung-adenocarcinoma-presenting-with-leptomeningeal-carcinomatosis-successfully-treated-with-afatinib-after-erlotinib-induced-hepatotoxicity
#17
Hiroaki Tanaka, Minehiko Inomata, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Toru Yamada, Toshiro Miwa, Tatsuhiko Kashii, Hirofumi Konishi, Kazuyuki Tobe
A 65-year-old man was diagnosed with leptomeningeal carcinomatosis based on the findings of cerebrospinal fluid cytology and magnetic resonance imaging(MRI).Treatment with erlotinib and bevacizumab was initiated, and partial improvement in consciousness and MRI findings were obtained.However, it was difficult to continue the treatment because of elevation in levels of liver enzymes and melena.We switched the treatment to afatinib monotherapy, and his consciousness improved immediately.Progression -free survival and overall survival from the initiation of the treatment with afatinib were 7 and 9...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28779849/the-necessity-of-intrathecal-chemotherapy-for-the-treatment-of-breast-cancer-patients-with-leptomeningeal-metastasis-a-systematic-review-and-pooled-analysis
#18
Yen-Chien Lee, Chung-Cheng Hsieh, Jen-Pin Chuang, Chung-Yi Li
Leptomeningeal carcinomatosis is a devastating disease. Despite its numerous complications, intrathecal (IT) chemotherapy remains a longstanding treatment for leptomeningeal carcinomatosis. Using case studies with internationally reported results, we attempted to determine the necessity of IT chemotherapy in treating leptomeningeal carcinomatosis. We conducted a systematic review and pooled analysis to compare hormone therapy, chemotherapy, and IT therapy. We excluded articles on IT trastuzumab therapy. We performed our literature search without language restriction...
September 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28739703/cerebrospinal-fluid-penetration-rate-and-efficacy-of-afatinib-in-patients-with-egfr-mutation-positive-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis-a-multicenter-prospective-study
#19
MULTICENTER STUDY
Akihiro Tamiya, Motohiro Tamiya, Takashi Nishihara, Takayuki Shiroyama, Keiko Nakao, Taisuke Tsuji, Naoko Takeuchi, Shun-Ichi Isa, Naoki Omachi, Norio Okamoto, Hidekazu Suzuki, Kyoichi Okishio, Ayano Iwazaki, Kimie Imai, Tomonori Hirashima, Shinji Atagi
BACKGROUND: Afatinib is an effective first-line treatment for epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC). However, few reports have addressed the influence of cerebrospinal fluid (CSF) penetration rate on the efficacy of afatinib in patients with central nervous system metastases. Therefore, we conducted a prospective multicenter trial to evaluate the CSF penetration rate and efficacy of afatinib in patients with EGFR mutation-positive NSCLC with leptomeningeal carcinomatosis...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28709170/-leptomeningeal-carcinomatosis-as-a-rare-metastatic-spreading-of-braf-mutated-microsatellite-stable-colon%C3%A2-cancer
#20
Aksana Höblinger, Stephanie Weber, Florian Tschirner, Stefan Kröber, Konrad Streetz
Leptomeningeal carcinomatosis is a rare but serious complication of solid tumors such as melanoma, breast and lung cancer, as well as gastrointestinal carcinomas. Its clinical manifestation is highly variable, presenting as radicular pain with or without neurological deficits, as well as with headaches and hallucinatory irritation symptoms. Leptomeningeal carcinomatosis is often misdiagnosed, which delays treatment. Here we report a rare case of a patient with BRAF-mutated microsatellite stable colon carcinoma with lymphatic and skeletal metastases, who developed neurological symptoms one month after the initial diagnosis of malignancy...
July 2017: Zeitschrift Für Gastroenterologie
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