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https://www.readbyqxmd.com/read/29607554/anti-inflammatory-potency-testing-of-topical-corticosteroids-and-calcineurin-inhibitors-in-human-volunteers-sensitized-to-diphenylcyclopropenone
#1
Kristian F Mose, Flemming Andersen, Mads A Røpke, Lone Skov, Peter S Friedmann, Klaus E Andersen
AIM: To quantify the anti-inflammatory potency of topical corticosteroids and topical calcineurin inhibitors by measuring the contact allergic response to a diphenylcyclopropenone (DPCP) challenge in de novo sensitized human volunteers. METHODS: Two randomized, double-blind, vehicle-controlled studies were performed encompassing 76 volunteers; 29 in the first and 47 in the second studies. Topical drugs were applied pre- and/or post-treatment in block designs. The compounds were tested simultaneously under occluded patch tests covering DPCP-induced dermatitis...
April 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29606811/can-the-cytokine-analysis-of-the-scales-on-alopecic-patch-predict-the-response-to-diphenylcyclopropenone-treatment-in-alopecia-areata-patients
#2
Si Hyub Lee, Jong Hyuk Moon, Dae Hyun Ban, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi
Background: Contact immune modulating therapy with diphenylcyclopropenone (DPCP) is a topical treatment option for extensive alopecia areata (AA). Because the response to DPCP treatment varies according to the patient, and it takes several months to evaluate the clinical effectiveness of the treatment, it is necessary to identify the factors that can predict the prognosis of the disease while treating with topical DPCP. Objective: In this study, cytokine levels in the scales of alopecic patches were investigated to identify whether they could predict response to DPCP during the early treatment period...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29528750/clinical-efficacy-of-diphenylcyclopropenone-immunotherapy-as-monotherapy-for-multiple-viral-warts
#3
Jun Yeong Park, Bok Won Park, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy. OBJECTIVES: We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and pulsed dye laser (PDL) therapy. We also assessed the impact of initial sensitization on clinical response. METHODS: We retrospectively analyzed the medical records of 250 patients with multiple viral warts between January 2008 and December 2015...
March 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29461966/anxiety-and-perceived-psychological-stress-play-an-important-role-in-the-immune-response-after-exercise
#4
Jason P Edwards, Neil P Walsh, Philip C Diment, Ross Roberts
There are common pathways by which psychological stress and exercise stress alter immunity. However, it remains unknown whether psychological stress plays a role in the in vivo immune response to exercise. We examined the relationship between anxiety and perceived psychological stress reported before exercise and in vivo immunity after exercise using skin sensitisation with Diphenylcyclopropenone (DPCP). In a randomised design, sixty four, thoroughly familiarised, males completed widely used psychological instruments to assess state-anxiety and perceived psychological stress before exercise, and ran either 30 minutes at 60% (30MI) or 80% (30HI) V ...
2018: Exercise Immunology Review
https://www.readbyqxmd.com/read/29442292/topical-immunotherapy-of-alopecia-areata-a-large-retrospective-study
#5
Nicola Zerbinati, Cristina Esposito, Edoardo D'Este, Alberto Calligaro, Rossano Valsecchi
INTRODUCTION: Topical immunotherapy is frequently used in the treatment of alopecia areata (AA) although few studies report long-term follow-up. Our goals were to determine the efficacy and the prognostic factors of topical immunotherapy in a large cohort of patients with AA treated in the departments of Dermatology and Venereology of Bergamo, Como and Pavia, from 1978 to January 2016. METHODS: A total of 252 patients with AA were evaluated retrospectively. RESULTS: All our patients developed an allergic reaction to a 2% solution of dinitrochlorobenzene (DNCB) or squaric acid dibutylester (SADBE) or diphenylcyclopropenone (DPCP)...
March 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29433103/exposure-to-organophosphate-flame-retardants-of-hotel-room-attendants-in-wuhan-city-china
#6
Yun Tao, Yinzhu Shang, Jing Li, Jingwen Feng, Zhenyu He, Adrian Covaci, Peng Wang, Jing Luo, Xiang Mao, Bin Shi, Liqin Hu, Dan Luo, Surong Mei
Indoor environments provide sources of exposure to organophosphate flame retardants (PFRs), which are artificially synthesized fire-protecting agents used as additives in interior products. As public spaces, hotels are required to meet stricter fire-precaution criteria. As such, room attendants may be exposed to higher levels of PFRs. Our goal was to characterize the exposure of hotel room attendants to PFRs by measuring metabolites in their urine and the corresponding parent PFRs in dust and hand-wipes collected from 27 hotels located in Wuhan City, China...
May 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29306213/urinary-metabolites-of-organophosphate-esters-in-children-in-south-china-concentrations-profiles-and-estimated-daily-intake
#7
Yi Chen, Jianzhang Fang, Lu Ren, Ruifang Fan, Jianqing Zhang, Guihua Liu, Li Zhou, Dingyan Chen, Yingxin Yu, Shaoyou Lu
Organophosphate esters (OPEs) are widely used in household products as flame retardants or plasticizers and have become ubiquitous pollutants in environmental media. However, little is known about OPE metabolites in humans, especially in children. In this study, eight OPE metabolites were measured in 411 urine samples collected from 6 to 14-year-old children in South China. Bis(2-chloroethyl) phosphate (BCEP), bis(1-chloro-2-propyl) phosphate (BCIPP) and diphenyl phosphate (DPHP) were the dominant OPE metabolites, and their median concentrations were 1...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29299216/a-retrospective-comparative-study-of-the-efficacy-and-safety-of-two-regimens-of-diphenylcyclopropenone-in-the-treatment-of-recalcitrant-alopecia-areata
#8
Tueboon Sriphojanart, Saranya Khunkhet, Poonkiat Suchonwanit
Diphenylcyclopropenone (DPCP) is an effective topical immunotherapy for recalcitrant alopecia areata (AA), which sometimes requires prolonged treatment. We developed a new treatment protocol to shorten the duration of therapy. This study aimed to compare the efficacy and safety of the new treatment protocol with the standard treatment protocol in the treatment of recalcitrant AA. We conducted a 6-year retrospective comparative study of patients with AA who received one of the DPCP treatment protocols at our institute...
October 11, 2017: Dermatology Reports
https://www.readbyqxmd.com/read/29274034/the-effects-of-bovine-colostrum-supplementation-on-in-vivo-immunity-following-prolonged-exercise-a-randomised-controlled-trial
#9
A W Jones, D S March, R Thatcher, B Diment, N P Walsh, Glen Davison
BACKGROUND: Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures. AIM: To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP). METHODS: In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days...
December 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29108907/subclinical-sensitization-with-diphenylcyclopropenone-is-sufficient-for-the-treatment-of-alopecia-areata-retrospective-analysis-of-159-cases
#10
Sung Jay Choe, Solam Lee, Long Quan Pi, Dong In Keum, Chung Hyeok Lee, Beom Jun Kim, Won-Soo Lee
BACKGROUND: Contact immunotherapy with diphenylcyclopropenone (DPCP) is presently considered the treatment of choice for extensive alopecia areata. However, a major concern with contact immunotherapy is that it causes various adverse effects (AEs) that contribute to discontinuation of treatment. OBJECTIVE: We investigated whether a modified DPCP treatment protocol can promote hair regrowth with fewer AEs. METHODS: All patients were sensitized with 0...
March 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29102155/exposure-to-organophosphate-flame-retardant-chemicals-in-the-u-s-general-population-data-from-the-2013-2014-national-health-and-nutrition-examination-survey
#11
Maria Ospina, Nayana K Jayatilaka, Lee-Yang Wong, Paula Restrepo, Antonia M Calafat
BACKGROUND: Use of organophosphate flame retardants (OPFRs) including tris(1,3-dichloro-2-propyl) phosphate, triphenyl phosphate, tris(1-chloro-2-propyl) phosphate, and tris-2-chloroethyl phosphate, in consumer products is on the rise because of the recent phase out of polybrominated diphenyl ether (PBDE) flame retardants. Some of these chemicals are also used as plasticizers or lubricants in many consumer products. OBJECTIVES: To assess human exposure to these chlorinated and non-chlorinated organophosphates, and non-PBDE brominated chemicals in a representative sample of the U...
January 2018: Environment International
https://www.readbyqxmd.com/read/28988173/protocol-for-the-tidal-melanoma-study-topical-imiquimod-or-diphenylcyclopropenone-for-the-management-of-cutaneous-in-transit-melanoma-metastases-a-phase-ii-single-centre-randomised-pilot-study
#12
Tavis Read, Scott Webber, Janine Thomas, Michael Wagels, Helmut Schaider, H Peter Soyer, B Mark Smithers
INTRODUCTION: Patients with in-transit melanoma metastases present a therapeutic challenge. Complete surgical excision of localised disease is considered as the gold standard; however, surgery is not always acceptable and alternatives are required. Treatment results reported using imiquimod and diphenylcyclopropenone (DPCP) suggest that topical immunotherapies can be used to successfully treat select patients with melanoma metastases. A phase II, randomised, single centre, pilot study was designed to assess the clinical efficacy and safety of DPCP and imiquimod for the treatment of superficial, cutaneous in-transit melanoma metastases...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28761264/a-case-report-of-verruca-vulgaris-on-basis-of-alopecia-areata-successfully-treated-with-diphenylcyclopropenone
#13
Tugba Kevser Uzuncakmak, Mahmut Can Koska, Ayşe Serap Karadağ, Necmettin Akdeniz
Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28749145/molecular-interactions-control-quantum-chain-reactions-toward-distinct-photoresponsive-properties-of-molecular-crystals
#14
Yanjun Gong, Yifan Zhang, Wei Xiong, Ke Zhang, Yanke Che, Jincai Zhao
In this work, we fabricated four diphenylcyclopropenone (DPCP) crystals, which involved various molecular interactions encoded in individual molecular structures 1-4. On the basis of crystalline structural analysis and photoresponsive characterization of the resultant single-crystal microribbons 1-4, we demonstrated that the magnitude of molecular interactions could effectively control the quantum chain reaction and the photoresponsive property of the DPCP crystals. The microribbons 1 and 2 having weak molecular interactions exhibited an efficient chain reaction and large mechanical photoresponses (i...
July 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28626861/diphenylcyclopropenone-for-the-treatment-of-cutaneous-in-transit-melanoma-metastases-results-of-a-prospective-non-randomized-single-centre-study
#15
T Read, S Webber, J Tan, M Wagels, H Schaider, H P Soyer, B M Smithers
BACKGROUND: Current treatments for in-transit melanoma (ITM) metastases are frequently invasive and do not improve overall survival. Recently, there has been increasing investigation into the use of topical agents. Diphenylcyclopropenone or diphencyprone (DPCP) is a novel, topical therapy that has been reported to have immune-sensitizing properties useful in the treatment of ITM. OBJECTIVE: To assess the clinical outcomes of patients treated within a prospective, non-randomized, non-comparative study using DPCP for cutaneous ITM metastases...
December 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28370374/the-gene-expression-and-immunohistochemical-time-course-of-diphenylcyclopropenone-induced-contact-allergy-in-healthy-humans-following-repeated-epicutaneous-challenges
#16
Kristian F Mose, Mark Burton, Mads Thomassen, Flemming Andersen, Torben A Kruse, Qihua Tan, Lone Skov, Mads A Røpke, Thomas Litman, Ole Clemmensen, Bjarne W Kristensen, Peter S Friedmann, Klaus E Andersen
The gene expression time-course of repeated challenge of contact allergy (CA) remains largely unknown. Therefore, using diphenylcyclopropenone (DPCP) as model allergen in healthy humans we set out to examine: (i) the monotonous and complex gene expression time-course trajectories following repeated DPCP challenges to find the predominant gene expression pattern, (ii) the time-course of cell infiltration following repeated DPCP challenges and (iii) the transcriptome of a repeated CA exposure model. We obtained punch biopsies from control and DPCP-exposed skin from ten DPCP sensitized individuals at 5-6 monthly elicitation challenges...
March 31, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191673/acquired-hair-curling-after-diphenylcyclopropenone-immunotherapy-in-alopecia-areata-patient
#17
LETTER
S J Choe, B J Kim, J Choi, W S Lee
No abstract text is available yet for this article.
August 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28121191/topical-immunotherapy-with-diphencyprone-dpcp-for-in-transit-and-unresectable-cutaneous-melanoma-lesions-an-inaugural-canadian-series
#18
Carrie Yeung, Teresa M Petrella, Frances C Wright, Wadid Abadir, Nicole J Look Hong
BACKGROUND: Diphencycprone (DPCP) is an immune contact sensitizer applied to melanoma lesions. Early studies show favorable efficacy. We present the first North-American series of patients treated with DPCP. METHODS: A single center retrospective study of patients with in-transit or unresectable melanoma lesions treated with DPCP from December 1,2014 to December 31,2015 was completed. Primary objectives were response rate and toxicity. Secondary objective was health-related quality of life assessment with the Functional Assessment of Cancer Therapy-Melanoma (FACT-M) questionnaire...
April 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28074525/efficacy-of-superficial-cryotherapy-on-the-eyebrows-of-patients-with-alopecia-universalis-also-treated-with-contact-immunotherapy-on-the-scalp-a-prospective-split-face-comparative-study
#19
COMPARATIVE STUDY
Sung Jay Choe, Won-Soo Lee
BACKGROUND: Few treatment modalities are available for treating alopecia areata (AA) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with AA of the eyebrow. METHODS: Superficial cryotherapy was performed every other week on the right eyebrow (SC-treated) in a total of 20 patients who had been previously treated with diphenylcyclopropenone (DPCP) immunotherapy on the scalp...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27061281/definite-regression-of-cutaneous-melanoma-metastases-upon-addition-of-topical-contact-sensitizer-diphencyprone-to-immune-checkpoint-inhibitor-treatment
#20
LETTER
Nicholas Gulati, Richard D Carvajal, Michael A Postow, Jedd D Wolchok, James G Krueger
No abstract text is available yet for this article.
July 2016: Experimental Dermatology
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