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https://www.readbyqxmd.com/read/29108907/subclinical-sensitization-with-diphenylcyclopropenone-is-sufficient-for-the-treatment-of-alopecia-areata-retrospective-analysis-of-159-cases
#1
Sung Jay Choe, Solam Lee, Long Quan Pi, Dong In Keum, Chung Hyeok Lee, Beom Jun Kim, Won-Soo Lee
BACKGROUND: Contact immunotherapy with diphenylcyclopropenone (DPCP) is presently considered the treatment of choice for extensive alopecia areata (AA). However, a major concern with contact immunotherapy is that it causes various adverse effects (AEs) that contribute to discontinuation of treatment. OBJECTIVE: We investigated whether a modified DPCP treatment protocol can promote hair regrowth with fewer AEs. METHODS: All patients were sensitized with 0...
November 3, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29102155/exposure-to-organophosphate-flame-retardant-chemicals-in-the-u-s-general-population-data-from-the-2013-2014-national-health-and-nutrition-examination-survey
#2
Maria Ospina, Nayana K Jayatilaka, Lee-Yang Wong, Paula Restrepo, Antonia M Calafat
BACKGROUND: Use of organophosphate flame retardants (OPFRs) including tris(1,3-dichloro-2-propyl) phosphate, triphenyl phosphate, tris(1-chloro-2-propyl) phosphate, and tris-2-chloroethyl phosphate, in consumer products is on the rise because of the recent phase out of polybrominated diphenyl ether (PBDE) flame retardants. Some of these chemicals are also used as plasticizers or lubricants in many consumer products. OBJECTIVES: To assess human exposure to these chlorinated and non-chlorinated organophosphates, and non-PBDE brominated chemicals in a representative sample of the U...
January 2018: Environment International
https://www.readbyqxmd.com/read/28988173/protocol-for-the-tidal-melanoma-study-topical-imiquimod-or-diphenylcyclopropenone-for-the-management-of-cutaneous-in-transit-melanoma-metastases-a-phase-ii-single-centre-randomised-pilot-study
#3
Tavis Read, Scott Webber, Janine Thomas, Michael Wagels, Helmut Schaider, H Peter Soyer, B Mark Smithers
INTRODUCTION: Patients with in-transit melanoma metastases present a therapeutic challenge. Complete surgical excision of localised disease is considered as the gold standard; however, surgery is not always acceptable and alternatives are required. Treatment results reported using imiquimod and diphenylcyclopropenone (DPCP) suggest that topical immunotherapies can be used to successfully treat select patients with melanoma metastases. A phase II, randomised, single centre, pilot study was designed to assess the clinical efficacy and safety of DPCP and imiquimod for the treatment of superficial, cutaneous in-transit melanoma metastases...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28761264/a-case-report-of-verruca-vulgaris-on-basis-of-alopecia-areata-successfully-treated-with-diphenylcyclopropenone
#4
Tugba Kevser Uzuncakmak, Mahmut Can Koska, Ayşe Serap Karadağ, Necmettin Akdeniz
Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28749145/molecular-interactions-control-quantum-chain-reactions-toward-distinct-photoresponsive-properties-of-molecular-crystals
#5
Yanjun Gong, Yifan Zhang, Wei Xiong, Ke Zhang, Yanke Che, Jincai Zhao
In this work, we fabricated four diphenylcyclopropenone (DPCP) crystals, which involved various molecular interactions encoded in individual molecular structures 1-4. On the basis of crystalline structural analysis and photoresponsive characterization of the resultant single-crystal microribbons 1-4, we demonstrated that the magnitude of molecular interactions could effectively control the quantum chain reaction and the photoresponsive property of the DPCP crystals. The microribbons 1 and 2 having weak molecular interactions exhibited an efficient chain reaction and large mechanical photoresponses (i...
July 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28626861/diphenylcyclopropenone-for-the-treatment-of-cutaneous-in-transit-melanoma-metastases-results-of-a-prospective-non-randomized-single-centre-study
#6
T Read, S Webber, J Tan, M Wagels, H Schaider, H P Soyer, B M Smithers
BACKGROUND: Current treatments for in-transit melanoma (ITM) metastases are frequently invasive and do not improve overall survival. Recently, there has been increasing investigation into the use of topical agents. Diphenylcyclopropenone or diphencyprone (DPCP) is a novel, topical therapy that has been reported to have immune-sensitizing properties useful in the treatment of ITM. OBJECTIVE: To assess the clinical outcomes of patients treated within a prospective, non-randomized, non-comparative study using DPCP for cutaneous ITM metastases...
June 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28370374/the-gene-expression-and-immunohistochemical-time-course-of-diphenylcyclopropenone-induced-contact-allergy-in-healthy-humans-following-repeated-epicutaneous-challenges
#7
Kristian F Mose, Mark Burton, Mads Thomassen, Flemming Andersen, Torben A Kruse, Qihua Tan, Lone Skov, Mads A Røpke, Thomas Litman, Ole Clemmensen, Bjarne W Kristensen, Peter S Friedmann, Klaus E Andersen
The gene expression time-course of repeated challenge of contact allergy (CA) remains largely unknown. Therefore, using diphenylcyclopropenone (DPCP) as model allergen in healthy humans we set out to examine: (i) the monotonous and complex gene expression time-course trajectories following repeated DPCP challenges to find the predominant gene expression pattern, (ii) the time-course of cell infiltration following repeated DPCP challenges and (iii) the transcriptome of a repeated CA exposure model. We obtained punch biopsies from control and DPCP-exposed skin from ten DPCP sensitized individuals at 5-6 monthly elicitation challenges...
March 31, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191673/acquired-hair-curling-after-diphenylcyclopropenone-immunotherapy-in-alopecia-areata-patient
#8
LETTER
S J Choe, B J Kim, J Choi, W S Lee
No abstract text is available yet for this article.
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28121191/topical-immunotherapy-with-diphencyprone-dpcp-for-in-transit-and-unresectable-cutaneous-melanoma-lesions-an-inaugural-canadian-series
#9
Carrie Yeung, Teresa M Petrella, Frances C Wright, Wadid Abadir, Nicole J Look Hong
BACKGROUND: Diphencycprone (DPCP) is an immune contact sensitizer applied to melanoma lesions. Early studies show favorable efficacy. We present the first North-American series of patients treated with DPCP. METHODS: A single center retrospective study of patients with in-transit or unresectable melanoma lesions treated with DPCP from December 1,2014 to December 31,2015 was completed. Primary objectives were response rate and toxicity. Secondary objective was health-related quality of life assessment with the Functional Assessment of Cancer Therapy-Melanoma (FACT-M) questionnaire...
April 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28074525/efficacy-of-superficial-cryotherapy-on-the-eyebrows-of-patients-with-alopecia-universalis-also-treated-with-contact-immunotherapy-on-the-scalp-a-prospective-split-face-comparative-study
#10
COMPARATIVE STUDY
Sung Jay Choe, Won-Soo Lee
BACKGROUND: Few treatment modalities are available for treating alopecia areata (AA) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with AA of the eyebrow. METHODS: Superficial cryotherapy was performed every other week on the right eyebrow (SC-treated) in a total of 20 patients who had been previously treated with diphenylcyclopropenone (DPCP) immunotherapy on the scalp...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27061281/definite-regression-of-cutaneous-melanoma-metastases-upon-addition-of-topical-contact-sensitizer-diphencyprone-to-immune-checkpoint-inhibitor-treatment
#11
LETTER
Nicholas Gulati, Richard D Carvajal, Michael A Postow, Jedd D Wolchok, James G Krueger
No abstract text is available yet for this article.
July 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/26963903/topical-immunotherapy-with-diphenylcyclopropenone-induced-vitiligo
#12
Zekayi Kutlubay, Burhan Engin, Abdullah Songur, Server Serdaroglu, Yalcin Tuzun
Topical immunotherapy made by diphenylcyclopropenone (DPCP) is an alternative treatment that can be used safely and efficaciously in recalcitrant alopecia areata patients. DPCP-induced vitiligo is a rare, but documented, unwanted side effect. The real mechanism of DPCP-induced vitiligo is not well known.
August 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/26869296/quantitative-determination-of-nine-urinary-metabolites-of-organophosphate-flame-retardants-using-solid-phase-extraction-and-ultra-performance-liquid-chromatography-coupled-to-tandem-mass-spectrometry-uplc-ms-ms
#13
Ivana Kosarac, Cariton Kubwabo, Warren G Foster
Over the last few years, the use of organophosphate flame retardants (OPFRs) has been on the rise; however, there are knowledge gaps in both the human health effects of OPFRs and levels of human exposure. Currently, human biomonitoring data on the levels of OPFR metabolites in the Canadian population are still non-existent. Herein we describe a novel method to measure nine urinary OPFR metabolites using solid phase extraction and ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS)...
March 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26556040/factors-contributing-to-the-treatment-duration-of-diphenylcyclopropenone-immunotherapy-for-periungual-warts
#14
Hyung Kwon Park, Joung Soo Kim
Diphenylcyclopropenone (DPCP) immunotherapy has been shown to be efficacious for the treatment of warts, especially periungual warts for which destructive techniques are limited. However, factors affecting the duration of treatment of periungual warts have not been studied. A total of 61 patients with periungual warts who were completely cured with DPCP immunotherapy were included in this study. Age, sex, disease duration, location (fingernail, toenail, or both), number of warts, diameter of the largest wart, application number for sensitization and two types of sensitization reactions, erythema and blister index (EBI), and pruritus index were evaluated...
March 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/26551948/clinical-efficacy-of-diphenylcyclopropenone-in-alopecia-areata-retrospective-data-analysis-of-50-patients
#15
Katherine S Chiang, Natasha A Mesinkovska, Melissa P Piliang, Wilma F Bergfeld
Diphenylcyclopropenone (DPCP) is widely considered the most effective topical immunotherapy for refractory or extensive alopecia areata (AA), but questions regarding how long to try DPCP therapy before terminating and what factors are prognostic of therapeutic success still remain unanswered. In this retrospective study of 50 AA patients, we evaluated DPCP efficacy and identified patient factors predictive of therapeutic success/failure. The median duration of DPCP treatment was 3 years, with 47% patients experiencing their first regrowth in the first 6 months of DPCP therapy, 20% between 6 months-1 year, and 8% between 1-2 years...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551938/diphencyprone-treatment-of-alopecia-areata-postulated-mechanism-of-action-and-prospects-for-therapeutic-synergy-with-rna-interference
#16
Karen G Bulock, James P Cardia, Pamela A Pavco, William R Levis
Diphencyprone (DPCP) is a potent topical sensitizing agent that has been used since the late 1970s by physicians for the treatment of alopecia areata (AA), viral warts (human papillomavirus) and cutaneous metastases of melanoma. Although to date the compound is not approved as a drug by the FDA or EMA, physicians have continued to use DPCP because of its proven effects in these dermatological conditions. The use of the drug has been highly variable because of differences in compounding, and as a result, the literature reports vary widely in the concentrations used for sensitization and challenge treatment with DPCP...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551655/assessing-the-patient-care-implications-of-concierge-and-other-direct-patient-contracting-practices-a-policy-position-paper-from-the-american-college-of-physicians
#17
Robert Doherty
As physicians seek innovative practice models, one that is gaining ground is for practices to contract with patients to pay directly for some or all services-often called cash-only, retainer, boutique, concierge, or direct primary care or specialty care practices. Such descriptions do not reflect the variability found in practices. For the purposes of this paper, the American College of Physicians (ACP) defines a direct patient contracting practice (DPCP) as any practice that directly contracts with patients to pay out-of-pocket for some or all of the services provided by the practice, in lieu of or in addition to traditional insurance arrangements, and/or charges an administrative fee to patients, sometimes called a retainer or concierge fee, often in return for a promise of more personalized and accessible care...
December 15, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26511831/diphenylcyclopropenone-in-patients-with-alopecia-areata-a-critically-appraised-topic
#18
REVIEW
R A Kuin, P I Spuls, J Limpens, E J van Zuuren
AIM: To assess the efficacy and safety of topical diphenylcyclopropenone (DPCP) in patients with alopecia areata. SETTING AND DESIGN: Study selection, data extraction, risk of bias assessment and analyses were carried out independently by two authors. The quality of evidence was rated with Grading of Recommendations Assessment, Development and Evaluation (GRADE). No randomised trials were identified, but 11 case series, conducted in dermatology departments in the Netherlands, UK, Iran, Italy, Egypt and Greece were included...
October 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/26236467/psoriasis-is-characterized-by-deficient-negative-immune-regulation-compared-to-transient-delayed-type-hypersensitivity-reactions
#19
Nicholas Gulati, Mayte Suárez-Fariñas, Joel Correa da Rosa, James G Krueger
Diphencyprone (DPCP) is a hapten that causes delayed-type hypersensitivity (DTH) reactions in human skin, and is used as a topical therapeutic for alopecia areata, warts, and cutaneous melanoma metastases.  We examined peak DTH reactions induced by DPCP (3 days post-challenge) by comprehensive gene expression and histological analysis.  To better understand how these DTH reactions naturally resolve, we compared our DPCP biopsies to those from patients with psoriasis vulgaris, a chronic inflammatory disease that does not resolve...
2015: F1000Research
https://www.readbyqxmd.com/read/26205579/unique-micrornas-appear-at-different-times-during-the-course-of-a-delayed-type-hypersensitivity-reaction-in-human-skin
#20
Nicholas Gulati, Marianne B Løvendorf, John R Zibert, Kemal M Akat, Neil Renwick, Thomas Tuschl, James G Krueger
Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH) reactions. MicroRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression and have been implicated in various inflammatory skin diseases, but their role in DTH reactions is not well understood. We generated global miRNA expression profiles (using next-generation sequencing) of DPCP reactions in skin of seven healthy volunteers at 3, 14 and 120 days after challenge. Compared to placebo-treated sites, DPCP-challenged skin at 3 days (peak inflammation) had 127 miRNAs significantly deregulated...
December 2015: Experimental Dermatology
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