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head trauma, brain injury,

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https://www.readbyqxmd.com/read/29905513/isolated-subdural-hematomas-in-mild-traumatic-brain-injury-part-1-the-association-between-radiographic-characteristics-and-neurosurgical-intervention
#1
Alessandro Orlando, A Stewart Levy, Benjamin A Rubin, Allen Tanner, Matthew M Carrick, Mark Lieser, David Hamilton, Charles W Mains, David Bar-Or
OBJECTIVE Isolated subdural hematomas (iSDHs) are one of the most common intracranial hemorrhage (ICH) types in the population with mild traumatic brain injury (mTBI; Glasgow Coma Scale score 13-15), account for 66%-75% of all neurosurgical procedures, and have one of the highest neurosurgical intervention rates. The objective of this study was to examine how quantitative hemorrhage characteristics of iSDHs in patients with mTBI at admission are associated with subsequent neurosurgical intervention. METHODS This was a 3...
June 15, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29903577/increased-reduction-in-exsanguination-rates-leaves-brain-injury-as-the-only-major-cause-of-death-in-blunt-trauma
#2
D Jochems, L P H Leenen, F Hietbrink, R M Houwert, K J P van Wessem
INTRODUCTION: Central nervous system (CNS) related injuries and exsanguination have been the most common causes of death in trauma for decades. Despite improvements in haemorrhage control in recent years exsanguination is still a major cause of death. We conducted a prospective database study to investigate the current incidence of haemorrhage related mortality. MATERIALS AND METHODS: A prospective database study of all trauma patients admitted to an urban major trauma centre between January 2007 and December 2016 was conducted...
May 23, 2018: Injury
https://www.readbyqxmd.com/read/29901458/dating-of-traumatic-brain-injury-in-forensic-cases-using-immunohistochemical-markers-i-neurofilaments-and-%C3%AE-amyloid-precursor-protein
#3
María de Los Ángeles Romero Tirado, José Manuel Blanco Pampin, Rosalía Gallego Gómez
Studies about head trauma are experimental or have a clinical or prognosis purpose. In this study, we used samples from human autopsies to answer common medical-legal questions.We studied 21 problem cases and 4 controls. Samples were obtained directly from the injured area, fixed in 10% formalin during 24 hours and then preserved in 70% ethanol. This procedure optimizes the immunohistochemical technique.The neurofilament antibody shows beaded axons since the first moment; over time, they increase their density and diameter as survival time also increases...
June 13, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29895273/prevalence-of-acute-stress-disorder-among-road-traffic-accident-survivors-a-meta-analysis
#4
Wenjie Dai, Aizhong Liu, Atipatsa C Kaminga, Jing Deng, Zhiwei Lai, Jianzhou Yang, Shi Wu Wen
BACKGROUND: Road traffic accident (RTA), an unexpected traumatic event, may not only lead to death and serious physical injuries, but also could put survivors at an increased risk for a wide range of psychiatric disorders, particularly acute stress disorder (ASD). Early assessment of trauma-related psychological responses is important because acute trauma responses in the early post-traumatic period are among the robust predictors of long-term mental health problems. However, estimates of the prevalence of ASD among RTA survivors varied considerably across studies...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29893758/early-and-rapid-detection-of-uchl1-in-the-serum-of-brain-trauma-patients-a-novel-gold-nanoparticle-based-method-for-diagnosing-the-severity-of-brain-injury
#5
Gyaninder Pal Singh, Richa Nigam, Gaurav Singh Tomar, Mohan Monisha, Sanjeev Kumar Bhoi, Arulselvi S, Kangana Sengar, Deepa Akula, Prashanth Panta, Roy Anindya
The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all centers. Human ubiquitin C-terminal hydrolase (UCHL1) is a well-accepted serum biomarker for severe TBI and can be used to detect the severity of a head injury. A reliable, rapid, cost effective, bedside and easy to perform method for the detection of UCHL1 is a pre-requisite for wide clinical applications of UCHL1 as a TBI biomarker...
June 12, 2018: Analyst
https://www.readbyqxmd.com/read/29893520/calculated-decisions-pecarn-pediatric-head-injury-trauma-algorithm
#6
Daniel Runde, Joshua Beiner
The PECARN Pediatric Head Injury Prediction Rule is a well-validated clinical decision aid that allows clinicians to safely rule out the presence of clinically important traumatic brain injuries.
June 1, 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29885319/the-90-day-prognostic-value-of-serum-cyclophilin-a-in-traumatic-brain-injury
#7
Hang-Huang Jin, Tian-Ming Mao, Zhi-Qiang Bai, Yuan Chen, Hai-Long Ji, Yong Jin
BACKGROUND: Cyclophilin A is involved in many inflammatory diseases and its expression is up-regulated after brain injury. We determined if serum cyclophilin A could be used as a marker for severity and 90-day outcome in patients with traumatic brain injury (TBI). METHODS: Serum cyclophilin A concentrations were quantified in 105 severe TBI patients and 105 healthy individuals. Its association with Glasgow Coma Scale (GCS) score, 90-day mortality and 90-day poor outcome (Glasgow Outcome Scale score of 1-3) were investigated...
June 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29878909/neuroimaging-of-brain-trauma
#8
David B Douglas, Jonathan L Muldermans, Max Wintermark
PURPOSE OF REVIEW: The purpose of this review is to provide an update on advanced neuroimaging techniques in traumatic brain injury (TBI). We will focus this review on recent literature published within the last 18 months and the advanced neuroimaging techniques of perfusion imaging and diffusion tensor imaging (DTI). RECENT FINDINGS: In the setting of a moderate or severe acute closed head injury (Glasgow Coma Scale <13), the most appropriate neuroimaging study is a noncontrast computed tomography (CT) scan...
June 6, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29876635/a-moving-human-body-causes-fatal-blunt-trauma-an-unusual-traffic-accident
#9
Annette Thierauf-Emberger, Andreas Lickert, Stefan Pollak
In urban traffic accidents, mainly pedestrians and cyclists are at risk of being injured and killed. Lethal injuries are usually caused by the immediate impact of a car or a tram. This paper presents a fatal accident without any direct contact with a motor vehicle. A 63-year-old woman sitting on a chair in a pavement cafe was killed by the impact of a 60-year-old male cyclist, who was flung in her direction after colliding with a car. Autopsy yielded intracutaneous haemorrhages on the impact sites of the female victim (left cheek, left shoulder and left upper arm)...
June 6, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29874782/trend-of-age-adjusted-rates-of-pediatric-traumatic-brain-injury-in-u-s-emergency-departments-from-2006-to-2013
#10
Cheng Chen, Jin Peng, Eric A Sribnick, Motao Zhu, Henry Xiang
Objective : To use the 2006⁻2013 Nationwide Emergency Department Sample (NEDS) database to describe trends of age-adjusted rates of pediatric traumatic brain injuries (TBI) treated in U.S. emergency departments. Methods : Time trend analysis was conducted on age-adjusted rates among children ≤17 years in the U.S. The annual percent change (APC) was calculated by fitting a least squares regression to the logarithm of the rates, using the calendar year as an independent variable. Results : In males, motor-vehicle-related trauma (APC -2...
June 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29870638/-guidelines-for-the-treatment-of-traumatic-brain-injury-2017
#11
REVIEW
András Büki, Pál Barzó, Béla Demeter, Péter Kanizsai, Erzsébet Ezer, Péter Tóth, Péter Horváth, Csaba Varga
Traumatic brain injury (TBI) is recognized to be the main cause of death and disability in the first four decades representing a major socio-economical problem worldwide. Recent communications revealed a particularly worrying image about the quality of care for TBI in Hungary. For any improvement a systematic approach characterized by utilization of scientific evidence based guidelines forming the basis for close monitoring of the actual care are considered a prerequisite. In Hungary the first evidence based guidelines in the field of TBI have been issued by the National Society for Anesthesiology and Intensive Care more than two decades ago followed by joint guidelines of the Hungarian Neurosurgical Society and the Hungarian College of Neurosurgeons...
July 30, 2017: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29867743/predictors-associated-with-post-traumatic-hydrocephalus-in-patients-with-head-injury-undergoing-unilateral-decompressive-craniectomy
#12
Qianxin Hu, Guangfu Di, Xuefei Shao, Wei Zhou, Xiaochun Jiang
Objective: Post-traumatic hydrocephalus (PTH) makes recovery from head trauma after decompression more complicated and is associated with high risks of clinical deterioration and poor outcomes. The aim of this study was to verify the predictors associated with the development of PTH in patients with head injury undergoing unilateral decompressive craniectomy (DC). Methods: Among traumatic brain injury (TBI) patients who underwent unilateral DC between January 2013 and December 2016, the clinical medical records, radiological information, and changes of patients' conditions in the 3-month after injury were reviewed retrospectively...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29851905/the-novel-oral-anticoagulants-noacs-have-worse-outcomes-compared-to-warfarin-in-patients-with-intracranial-hemorrhage-after-tbi
#13
Muhammad Zeeshan, Faisal Jehan, Terence O'Keeffe, Muhammad Khan, El Rasheid Zakaria, Mohammad Hamidi, Lynn Gries, Narong Kulvatunyou, Bellal Joseph
INTRODUCTION: Novel-oral-anticoagulants(NOACs) use is increasing in trauma patients. The reversal of these agents after hemorrhage is still evolving. The aim of our study was to evaluate outcomes after traumatic brain injury in patients on NOACs. METHODS: 3-year (2014-2016) analysis of our prospectively maintained TBI database. We included all TBI patients with intracranial-hemorrhage (ICH) on anticoagulants. Patients were stratified into two groups; those on NOACs and on Warfarin, and were matched in a 1:2 ratio using propensity score matching for demographics, injury and vital parameters, type, and size of ICH...
May 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29802602/dependence-on-subconcussive-impacts-of-brain-metabolism-in-collision-sport-athletes-an-mr-spectroscopic-study
#14
Sumra Bari, Diana O Svaldi, Ikbeom Jang, Trey E Shenk, Victoria N Poole, Taylor Lee, Ulrike Dydak, Joseph V Rispoli, Eric A Nauman, Thomas M Talavage
Long term neurological impairments due to repetitive head trauma are a growing concern for collision sport athletes. American Football has the highest rate of reported concussions among male high school athletes, a position held by soccer for female high school athletes. Recent research has shown that subconcussive events experienced by collision sport athletes can be a further significant source of accrued damage. Collision sport athletes experience hundreds of subconcussive events in a single season, and these largely go uninvestigated as they produce no overt clinical symptoms...
May 25, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29801909/infantile-traumatic-brain-injury-with-a-biphasic-clinical-course-and-late-reduced-diffusion
#15
Nanako Takase, Noboru Igarashi, Hiromichi Taneichi, Kumi Yasukawa, Takafumi Honda, Hiromichi Hamada, Jun-Ichi Takanashi
Reduced diffusion in the subcortical white matter has been reported in some infants with traumatic brain injury (TBI), including abusive head trauma. However, the pathomechanisms of the lesions and clinical features are uncertain. We herein report two infants with TBI who presented with biphasic clinical courses and late reduced diffusion in the subcortical white matter, and reviewed seven clinically and radiologically similar patients with TBI. Their clinical features (secondary neurological symptoms on days 3 to 6) and radiological findings (normal diffusion on days 1 to 2, followed by reduced diffusion on days 3 to 6) are very similar to those observed in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)...
July 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29800829/microvascular-and-large-vein-abnormalities-in-young-patients-after-mild-head-trauma-and-associated-fatigue-a-brain-spect-evaluation-and-posture-dependence-modeling
#16
Tiffany Crider, Derrick Eng, Pooja R Sarkar, Janet Cordero, John Claude Krusz, Subhendra N Sarkar
OBJECTIVE: MRI and CT scans are usually normal in mild traumatic brain injury (mTBI) although 15-20% of such patients suffer for months from fatigue, headache, anxiety, sleep and other disorders. mTBI is suspected to be a cerebrovascular injury, similar to moderate and severe TBI. Brain SPECT is more sensitive and shows perfusion abnormalities immediately after mTBI. This work explores the perfusion abnormalities for young patients suffering from fatigue several months after mTBI. PATIENTS AND METHODS: Twelve mTBI patients (age:8-36 yr, 4 male) with no history of fatigue prior to trauma were prospectively studied following onset of fatigue 6-12 months after mTBI utilizing 99 m-Tc ECD brain SPECT with early and delayed radiotracer imaging...
July 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29796153/head-ct-guidelines-following-concussion-among-the-youngest-trauma-patients-can-we-limit-radiation-exposure-following-traumatic-brain-injury
#17
Bryan J Harvell, Stephen D Helmer, Jeanette G Ward, Elizabeth Ablah, Raymond Grundmeyer, James M Haan
Introduction: Recent studies have provided guidelines on the use of head computed tomography (CT) scans in pediatric trauma patients. The purpose of this study was to identify the prevalence of these guidelines among concussed pediatric patients. Methods: A retrospective review was conducted of patients four years or younger with a concussion from blunt trauma. Demographics, head injury characteristics, clinical indicators for head CT scan (severe mechanism, physical exam findings of basilar skull fracture, non-frontal scalp hematoma, Glasgow Coma Scale score, loss of consciousness, neurologic deficit, altered mental status, vomiting, headache, amnesia, irritability, behavioral changes, seizures, lethargy), CT results, and hospital course were collected...
May 2018: Kansas journal of medicine
https://www.readbyqxmd.com/read/29794235/prevalence-of-cerebral-microhemorrhage-following-chronic-blast-related-mild-traumatic-brain-injury-in-military-service-members-using-susceptibility-weighted-mri
#18
E Lotan, C Morley, J Newman, M Qian, D Abu-Amara, C Marmar, Y W Lui
BACKGROUND AND PURPOSE: Cerebral microhemorrhages are a known marker of mild traumatic brain injury. Blast-related mild traumatic brain injury relates to a propagating pressure wave, and there is evidence that the mechanism of injury in blast-related mild traumatic brain injury may be different from that in blunt head trauma. Two recent reports in mixed cohorts of blunt and blast-related traumatic brain injury in military personnel suggest that the prevalence of cerebral microhemorrhages is lower than in civilian head injury...
May 24, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29788111/acute-assessment-of-traumatic-brain-injury-and-post-traumatic-stress-after-exposure-to-a-deployment-related-explosive-blast
#19
Monty T Baker, John C Moring, Willie J Hale, Jim Mintz, Stacey Young-McCaughan, Richard A Bryant, Donna K Broshek, Jeffrey T Barth, Robert Villarreal, Cynthia L Lancaster, Steffany L Malach, Jose M Lara-Ruiz, William Isler, Alan L Peterson
Introduction: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are two of the signature injuries in military service members who have been exposed to explosive blasts during deployments to Iraq and Afghanistan. Acute stress disorder (ASD), which occurs within 2-30 d after trauma exposure, is a more immediate psychological reaction predictive of the later development of PTSD. Most previous studies have evaluated service members after their return from deployment, which is often months or years after the initial blast exposure...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29787544/a-clinical-prediction-model-for-raised-intracranial-pressure-in-patients-with-traumatic-brain-injuries
#20
J Pace, N Parry, K Vogt, R Hilsden, R Leeper, Z Markova, F Priestap, J Younan, I M Ball
BACKGROUND: Intracranial hypertension is believed to contribute to secondary brain insult in traumatically brain injured patients. Currently the diagnosis of intracranial hypertension requires intracranial monitoring or advanced imaging. Unfortunately, prehospital transport times can be prolonged, delaying time to the initial radiographic assessment. The aim of this study was to identify clinical variables associated with raised intracranial pressure (ICP) prior to the completion of neuroimaging...
April 30, 2018: Journal of Trauma and Acute Care Surgery
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