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https://www.readbyqxmd.com/read/29911612/high-throughput-screening-reveals-enzyme-and-gpcr-targets-as-putative-binding-sites-for-d-deprenyl
#1
A Lesniak, A Jonsson, M Aarnio, T Norberg, F Nyberg, T Gordh
Aims In PET studies of patients suffering from chronic pain following whip lash trauma, d-deprenyl was shown to bind to painful sites in the neck [1]. High uptake points towards an existence of an inflammation-specific binding site. Thus, the aim of this study was to identify the binding site for d-deprenyl employing radioligand receptor binding and high-throughput analysis of its activity towards 165 G-protein coupled receptors and 84 enzyme targets commonly used in drug discovery and development. Methods D-Deprenyl activity towards GPCR targets was assessed by DiscoverX in CHO-K1 EDG1 β-arrest in EFC cell line utilizing the PathHunter™ technique...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29882233/periocular-co-2-laser-resurfacing-severe-ocular-complications-from-multiple-unintentional-laser-impacts-on-the-protective-metal-eye-shields
#2
Martin J C van Gemert, Paul R Bloemen, Wei-Yong Wang, Cees W M van der Geld, Rudy M M A Nuijts, Hayri Hortoglu, Albert Wolkerstorfer, Daniel M de Bruin, Ton G van Leeuwen, H A Martino Neumann, Martine J Jager
BACKGROUND AND OBJECTIVES: A 36-year-old woman underwent CO2 laser resurfacing for periocular rhytides using protective stainless steel Cox II ocular shields. Immediately after the treatment, corneal lesions were seen in both eyes. The left eye subsequent developed corneal ulceration and scarring, a deformed iris, cataract, and lower eye lashes showing signs of acute burns. The right cornea had a small inferior mid-peripheral superficial lesion and concomitant lower mid-peripheral burned eye lashes...
June 8, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29880471/self-reported-tobacco-alcohol-and-illicit-drug-use-and-progression-of-chronic-kidney-disease
#3
Joshua D Bundy, Lydia A Bazzano, Dawei Xie, Janet Cohan, Jacqueline Dolata, Jeffrey C Fink, Chi-Yuan Hsu, Kenneth Jamerson, James Lash, Gail Makos, Susan Steigerwalt, Xue Wang, Katherine T Mills, Jing Chen, Jiang He
BACKGROUND AND OBJECTIVES: Previous studies suggest that tobacco, alcohol, and illicit drug use is associated with CKD. We examined the associations of substance use with CKD progression and all-cause mortality among patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Chronic Renal Insufficiency Cohort Study is a prospective, longitudinal cohort study among 3939 participants with CKD in the United States. Self-reported tobacco smoking, alcohol drinking, marijuana use, and hard illicit drug (cocaine, heroin, or methamphetamine) use were obtained at baseline and annual follow-up visits...
June 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29868381/acculturation-and-chronic-kidney-disease-in-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#4
Claudia M Lora, Ana C Ricardo, Jinsong Chen, Jianwen Cai, Michael Flessner, Ashley Moncrieft, Carmen Peralta, Leopoldo Raij, Sylvia E Rosas, Gregory A Talavera, Martha L Daviglus, James P Lash
Hispanics/Latinos are burdened by chronic kidney disease (CKD). The role of acculturation in this population has not been explored. We studied the association of acculturation with CKD and cardiovascular risk factor control. We performed cross-sectional analyses of 13,164 U.S. Hispanics/Latinos enrolled in the HCHS/SOL Study between 2008 and 2011. Acculturation was measured using the language and ethnic social relations subscales of the Short Acculturation Scale for Hispanics, and proxies of acculturation (language preference, place of birth and duration of residence in U...
June 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29858518/use-of-antipsychotics-and-risk-of-breast-cancer-a-danish-nationwide-case-control-study
#5
Anton Pottegård, Timothy L Lash, Deirdre Cronin-Fenton, Thomas P Ahern, Per Damkier
AIMS: Some antipsychotics increases prolactin levels, which might increase the risk of breast cancer. Existing evidence is conflicting and based on sparse data, especially for the increasingly used second-generation antipsychotics. We conducted a nationwide case-control study of the association between antipsychotic use and incident breast cancer. METHODS: From the Danish Cancer Registry, we identified women with a first-time diagnosis of breast cancer 2000-2015 (n=60,360)...
June 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29802423/direct-anterior-approach-to-the-hip-joint-in-the-lateral-decubitus-position-for-joint-replacement
#6
REVIEW
R S Camenzind, K Stoffel, N J Lash, M Beck
SURGICAL PRINCIPLE AND OBJECTIVE: The direct anterior approach for total hip arthroplasty is associated with higher complication rates and difficult femoral component positioning. Performing a modified technique in the lateral position allows secure component positioning. INDICATIONS: Primary hip replacement (including femoral neck fracture) and cup revision without bone deficiency. CONTRAINDICATIONS: Destruction/deformities of proximal femur or acetabulum, bone deficiency or malignancy...
May 25, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29797270/introduction-to-hair-development
#7
Duane P Harland
The anagen phase of the hair follicle cycle is when the follicle is configured to grow hair. In short hairs (e.g., mouse underhairs and human eye lashes) anagen phase is short, but in the wool of sheep and in human scalp hair anagen is a prolonged state lasting for years. In this chapter we describe the morphological and biological divisions within the anagen follicle.
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29788401/enabling-clinicians-to-easily-find-location-based-travel-health-recommendations-is-innovation-needed
#8
R Ryan Lash, Allison Taylor Walker, C Virginia Lee, Regina LaRocque, Sowmya R Rao, Edward T Ryan, Gary Brunette, Kelly Holton, Mark J Sotir
Background: The types of place names and the level of geographic detail that patients report to clinicians regarding their intended travel itineraries vary. The reported place names may not match those in published travel health recommendations, making traveler-specific recommendations potentially difficult and time-consuming to identify. Most published recommendations are at the country level; however, subnational recommendations exist when documented disease risk varies within a country, as for malaria and yellow fever...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29771735/re-beta-blockers-and-improved-progression-free-survival-in-patients-with-advanced-her2-negative-breast-cancer
#9
Gitte Vrelits Sørensen, Deirdre P Cronin-Fenton, Henrik Toft Sørensen, Per Damkier, Bent Ejlertsen, Peer M Christiansen, Timothy L Lash, Thomas P Ahern
No abstract text is available yet for this article.
May 16, 2018: Epidemiology
https://www.readbyqxmd.com/read/29758559/circrna-0004904-circrna-0001855-and-papp-a-potential-novel-biomarkers-for-the-prediction-of-preeclampsia
#10
Min Jiang, Gendie E Lash, Xueqing Zhao, Yan Long, Caijiao Guo, Hongling Yang
BACKGROUND/AIMS: Circular RNAs (circRNAs) are transcribed prevalently in the genome; however, their potential roles in multiple cardiovascular diseases, particularly preeclampsia (PE), are not yet well understood. This study investigated the expression profiles of circRNAs and explored circRNA-mediated pregnancy-associated plasma protein A (PAPP-A) expression as a potential biomarker for PE before 20 weeks of pregnancy. METHODS: A nested case-control two-phase screening/validation study was performed in pregnant women before 20 weeks of gestation (before clinical diagnosis) at Guangzhou Women and Children's Medical Center from 2012 to 2015...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29738843/transporter-dependent-cytotoxicity-of-antiviral-drugs-in-primary-cultures-of-human-proximal-tubular-cells
#11
Lawrence H Lash, Caroline A Lee, Clynn Wilker, Vishal Shah
The role of plasma membrane transporters in the nephrotoxicity of two antiretroviral drugs, cidofovir and tenofovir, was studied in primary cultures of human proximal tubular (hPT) cells. Cells were grown on Transwell filter inserts to maintain epithelial polarity and access to either the apical or basolateral plasma membrane. The function of relevant membrane transporters, organic anion transporter 1 and 3 (OAT1/3), P-glycoprotein (multidrug resistance protein-1; P-gp or MDR1), and organic cation transporter 2 (OCT2), was validated by measurements of apical-to-basolateral and basolateral-to-apical fluxes of furosemide, digoxin, and metformin, respectively...
May 5, 2018: Toxicology
https://www.readbyqxmd.com/read/29728316/cognitive-impairment-in-non-dialysis-dependent-ckd-and-the-transition-to-dialysis-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#12
Meera N Harhay, Dawei Xie, Xiaoming Zhang, Chi-Yuan Hsu, Eric Vittinghoff, Alan S Go, Stephen M Sozio, Jacob Blumenthal, Stephen Seliger, Jing Chen, Rajat Deo, Mirela Dobre, Sanjeev Akkina, Peter P Reese, James P Lash, Kristine Yaffe, Manjula Kurella Tamura
BACKGROUND: Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN: Retrospective observational study. SETTING & PARTICIPANTS: 630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate ≤ 20mL/min/1...
May 2, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29723935/a-systematic-review-and-bayesian-network-meta-analysis-of-risk-of-intracranial-hemorrhage-with-direct-oral-anticoagulants
#13
Zachary Wolfe, Safi U Khan, Fahad Nasir, Charumathi Raghu Subramanian, Bradley Lash
BACKGROUND: The comparative risk of intracranial hemorrhage (ICH) among direct oral anticoagulants (DOACs) (dabigatran, rivaroxaban, apixaban, and edoxaban) remains unclear. OBJECTIVE: To determine the difference in risk of ICH between DOACs. METHODS: 17 randomized controlled trials (RCTs) were selected using PubMed/MEDLINE, EMBASE, CENTRAL (Inception - 31 December 2017). Estimates were reported as odds ratio (OR) with 95% credible interval (CR...
May 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29698779/nonsurgical-correction-of-epiblepharon-using-hyaluronic-acid-gel
#14
Milind N Naik, Aditi Pujari, Mohammad Javed Ali, Swathi Kaliki, Tarjani Vivek Dave
PURPOSE: To report a single-center experience with nonsurgical correction of epiblepharon using hyaluronic acid gel. METHODS: The medical records of consecutive patients with symptomatic epiblepharon treated over a 3-year period with hyaluronic acid gel injection were reviewed retrospectively. Hyaluronic acid gel was injected transcutaneously into the suborbicularis plane to obliterate the abnormal skin fold or evert the eyelid margin. Successful treatment was defined as eversion of the eyelid margin as assessed by lash-cornea touch...
June 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29688114/adjustment-disorder-and-type-specific-cancer-incidence-a-danish-cohort-study
#15
Thomas P Ahern, Katalin Veres, Tammy Jiang, Dóra Körmendiné Farkas, Timothy L Lash, Henrik Toft Sørensen, Jaimie L Gradus
BACKGROUND: Although adjustment disorder is common, there is a dearth of research on its physical health consequences. Earlier studies, biological mechanisms and stress-related behaviors suggest that cancer may be a potential sequelae of adjustment disorder. This study examined the association between adjustment disorder and type-specific cancer incidence in a nationwide cohort. METHODS: Data were obtained from the comprehensive nationwide medical and administrative registries of Denmark...
April 24, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29686150/evaluation-of-amphotericin-b-lipid-formulations-for-treatment-of-severe-coccidioidomycosis
#16
Ritam Sidhu, David B Lash, Arash Heidari, Piruthiviraj Natarajan, Royce H Johnson
BACKGROUND: Patients with severe coccidioidomycosis infections are often treated with either amphotericin-B lipid complex (ABLC) or liposomal amphotericin-B (L-AmB). Outcomes data with these agents in severe coccidioidomycosis are currently lacking. The purpose of this study is to evaluate the efficacy and toxicity of ABLC and L-AmB in treating severe coccidioidomycosis. METHODS: A retrospective, pre-post study design was employed. Chart reviews were completed from 01/01/2005 to 12/31/2014 for all patients who received lipid-based amphotericin B...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29661941/mental-health-of-transgender-and-gender-nonconforming-youth-compared-with-their-peers
#17
Tracy A Becerra-Culqui, Yuan Liu, Rebecca Nash, Lee Cromwell, W Dana Flanders, Darios Getahun, Shawn V Giammattei, Enid M Hunkeler, Timothy L Lash, Andrea Millman, Virginia P Quinn, Brandi Robinson, Douglas Roblin, David E Sandberg, Michael J Silverberg, Vin Tangpricha, Michael Goodman
BACKGROUND: Understanding the magnitude of mental health problems, particularly life-threatening ones, experienced by transgender and/or gender nonconforming (TGNC) youth can lead to improved management of these conditions. METHODS: Electronic medical records were used to identify a cohort of 588 transfeminine and 745 transmasculine children (3-9 years old) and adolescents (10-17 years old) enrolled in integrated health care systems in California and Georgia. Ten male and 10 female referent cisgender enrollees were matched to each TGNC individual on year of birth, race and/or ethnicity, study site, and membership year of the index date (first evidence of gender nonconforming status)...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29661541/ckd-and-esrd-in-us-hispanics
#18
REVIEW
Nisa Desai, Claudia M Lora, James P Lash, Ana C Ricardo
Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among Hispanics. Furthermore, Hispanic ethnicity has been associated with a greater prevalence of cardiovascular disease risk factors, including obesity and diabetes, as well as CKD-related complications...
April 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29628359/gene-expression-phenotype-associations-in-adults-with-eosinophilic-esophagitis
#19
Evan S Dellon, Sara R Selitsky, Robert M Genta, Richard H Lash, Joel S Parker
BACKGROUND: Gene expression patterns have not been extensively examined in the context of clinical features of eosinophilic esophagitis (EoE). AIMS: To assess whether gene expression is associated with clinically defined phenotypes in adults with EoE. METHODS: This was an analysis of prospectively collected esophageal biopsies in newly diagnosed EoE patients. We determined differential gene expression with a 94 gene panel in relation to clinical features and phenotypes...
March 27, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29608884/detection-of-mutations-in-barrett-s-esophagus-before-progression-to-high-grade-dysplasia-or-adenocarcinoma
#20
Matthew D Stachler, Nicholas D Camarda, Christopher Deitrick, Anthony Kim, Agoston T Agoston, Robert D Odze, Jason L Hornick, Anwesha Nag, Aaron R Thorner, Matthew Ducar, Amy Noffsinger, Richard H Lash, Mark Redston, Scott L Carter, Jon M Davison, Adam J Bass
BACKGROUND & AIMS: Barrett's esophagus (BE) is the greatest risk factor for esophageal adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer. Biomarkers might be able to identify patients at highest risk of progression. We investigated genomic differences in surveillance biopsies collected from patients whose BE subsequently progressed compared to patients whose disease did not progress. METHODS: We performed a retrospective case-control study of 24 patients with BE that progressed to high-grade dysplasia (HGD, n = 14) or EAC (n = 10)...
March 31, 2018: Gastroenterology
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