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https://www.readbyqxmd.com/read/28695614/use-of-anti-inflammatory-analgesics-in-sickle-cell-disease
#1
J Han, S L Saraf, J P Lash, V R Gordeuk
WHAT IS KNOWN AND OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used to treat pain in sickle-cell disease (SCD), but NSAID use is associated with renal, gastrointestinal and cardiovascular toxicities. Our objective was to evaluate the use of aspirin and non-aspirin NSAIDs in SCD. COMMENT: Despite analgesic and anti-inflammatory benefits in SCD, non-aspirin NSAIDs are associated with renal, cardiovascular and gastrointestinal toxicities in this patient population...
July 10, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28685227/postoperative-sexual-functioning-in-total-versus-subtotal-laparoscopic-hysterectomy-what-do-women-expect
#2
Sebastian Berlit, Stefanie Lis, Sven Jürgens, Olaf Buchweitz, Amadeus Hornemann, Marc Sütterlin, Benjamin Tuschy
PURPOSE: To evaluate sexual functioning and expected changes in sexual functioning in women with planned total versus subtotal laparoscopic hysterectomy. METHODS: A total of 120 women undergoing laparoscopic hysterectomy were preoperatively enrolled in this study with a cross-sectional design. Full data sets were available for 112 patients, so that 56 patients with planned total laparoscopic hysterectomy (TLH) and 56 women with planned laparoscopic supracervical hysterectomy (LASH) were preoperatively assessed...
July 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28681219/lash-a-review-of-the-current-literature
#3
REVIEW
William Kingston, Rashmi Halker
PURPOSE OF REVIEW: The purpose of this review is to evaluate and explain our current understanding of a very rare disorder, long-lasting autonomic symptoms with associated hemicranias (LASH). RECENT FINDINGS: At present, there are four known cases in the literature of LASH. Its characteristics and reported response to indomethacin link it most closely to the trigeminal autonomic cephalalgias (TACs). Its pathophysiology and epidemiology remain unclear. Variance in the pain and autonomic symptom relationship in the existing TAC literature along with the reports of TAC sine headache suggests that LASH may represent a far end of the spectrum of TACs, with most similarities to paroxysmal hemicrania (PH) and hemicrania continua (HC)...
August 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28668198/academic-physicians-views-on-low-value-services-and-the-choosing-wisely-campaign-a-qualitative-study
#4
Tara F Bishop, Meagan Cea, Yesenia Miranda, Robert Kim, Meredith Lash-Dardia, Jennifer I Lee, Peter Steel, Jordan Goldberg, Elaine Mechanic, Victoria Fener, Linda M Gerber
BACKGROUND: In 2012, the American Board of Internal Medicine (ABIM) Foundation launched a campaign called Choosing Wisely which was intended to start a national dialogue on services that are not medically necessary. More research is needed on the in-depth reasons why doctors overuse low-value services, their views on Choosing Wisely specifically, and ways to help them change their practice patterns. METHODS: We performed a qualitative study of focus groups with physicians to explore their views on the problem of overuse of low-value services, the reasons why they overuse, and ways that they think could be effective at curbing overuse...
March 2017: Healthcare
https://www.readbyqxmd.com/read/28643350/habitual-sleep-and-kidney-function-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort-study
#5
Kristen L Knutson, James Lash, Ana C Ricardo, James Herdegen, J D Thornton, Mahboob Rahman, Nicolas Turek, Janet Cohan, Lawrence J Appel, Lydia A Bazzano, Manjula K Tamura, Susan P Steigerwalt, Matthew R Weir, Eve Van Cauter
Physiological evidence suggests that sleep modulates kidney function. Our objective was to examine the cross-sectional association between kidney function and objectively-estimated habitual sleep duration, quality and timing in a cohort of patients with mild to moderate chronic kidney disease. This study involved two US clinical centers of the Chronic Renal Insufficiency Cohort (CRIC) study, including 432 participants in a CRIC ancillary sleep study. Habitual sleep duration, quality and timing were measured using wrist actigraphy for 5-7 days...
June 23, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28643021/the-effect-of-14-3-3%C3%AE-expression-on-tamoxifen-resistance-and-breast-cancer-recurrence-a-danish-population-based-study
#6
Jake E Thistle, Ylva Hellberg, Kristina Mortensen, Stephen Hamilton-Dutoit, Anders Kjærsgaard, Deirdre Cronin-Fenton, Henrik Toft Sørensen, Timothy L Lash
PURPOSE: Overexpression of 14-3-3ζ has been linked to breast cancer recurrence in several studies, including studies assessing its effect on tamoxifen resistance. The study was performed to estimate the effect of 14-3-3ζ and differentiate potential prognostic or predictive utility. METHODS: A case-control study, nested in a population of 11,251 females residing on the Jutland Peninsula of Denmark, was performed. Participants were aged 35-69, diagnosed with stage I, II, or III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Cooperative Group...
June 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28632014/coaching-the-coach-a-program-for-development-of-faculty-portfolio-coaches
#7
Jack Kopechek, Cheryl Bardales, A Todd Lash, Curtis Walker, Sheryl Pfeil, Cynthia H Ledford
PROBLEM: Faculty coaching is recognized as an essential element for effective use of portfolios in undergraduate medical education, yet best practices for training these coaches are uncertain. INTERVENTION: New portfolio coaches participated in a multifaceted training program that included orienting modules, a 7.5-hr training workshop featuring analysis of reflective writing, an Observed Structured Teaching Exercise (OSTE), and subsequent longitudinal coaches' meetings for timely task training...
July 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28588625/change-in-bmi-after-radioactive-iodine-ablation-for-graves-disease
#8
Melinda Chen, Matthew Lash, Todd Nebesio, Erica Eugster
BACKGROUND: We aimed to determine the extent of post-treatment weight gain that occurs in pediatric patients in the first year following radioactive iodine (RAI) therapy for Graves disease (GD) and its relationship to clinical characteristics. METHODS: A retrospective chart review of patients receiving RAI therapy for GD between 1998-2015 was performed. Change in BMI SDS (∆BMI SDS) from baseline to one year after treatment was determined. We also investigated whether individual clinical and/or biochemical factors were associated with the weight trajectory in these patients...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/28585885/validity-of-danish-breast-cancer-group-dbcg-registry-data-used-in-the-predictors-of-breast-cancer-recurrence-probecare-premenopausal-breast-cancer-cohort-study
#9
Deirdre P Cronin-Fenton, Anders Kjærsgaard, Thomas P Ahern, Marco Mele, Marianne Ewertz, Stephen Hamilton-Dutoit, Peer M Christiansen, Bent Ejlertsen, Henrik T Sørensen, Timothy L Lash, Rebecca A Silliman
BACKGROUND: Validation studies of the Danish Breast Cancer Group (DBCG) registry show good agreement with medical records for adjuvant treatment data, but inconsistent recurrence information. No studies have validated changes in menopausal status or endocrine therapy during follow-up. In a longitudinal study, we validated DBCG data using medical records as the gold standard. MATERIAL AND METHODS: From a cohort of 5959 premenopausal women diagnosed during 2002-2010 with stage I-III breast cancer, we selected 151 patients - 77 estrogen-receptor-positive and 74 estrogen-receptor-negative - from three hospitals...
June 6, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28576402/-anterior-lamellar-resection-with-lid-margin-split-of-the-upper-eyelid-in-the-treatment-of-trachomatous-entropion
#10
M Bouazza, M Elbelhadji, S Cherkaoui, A Mchachi, L Benhmidoune, A Chakib, R Rachid, A Amraoui
INTRODUCTION: The goal of this study is to assess functional and aesthetic results of anterior lamellar resection with lid margin splitting of the upper lid in the treatment of cicatricial trachomatous entropion. PATIENTS AND METHODS: Descriptive cross-sectional study of a series of 26 consecutive patients treated between January 2014 and December 2015. All patients were operated for cicatricial trachomatous entropion in our tertiary center using the technique of the anterior lamellar resection with lid margin splitting of the upper eyelid...
May 30, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28574261/pyreniporphyrins-porphyrin-analogues-that-incorporate-a-polycyclic-aromatic-hydrocarbon-subunit-within-the-macrocyclic-framework
#11
Ruixiao Gao, Deyaa I AbuSalim, Timothy D Lash
The first examples of porphyrin analogues incorporating pyrene units are reported. Acid-catalyzed condensation of a pyrene dialdehyde with a tripyrrane, followed by oxidation with DDQ, afforded a polycyclic aromatic hydrocarbon (PAH)-porphyrin hybrid in 38% yield. Pyreniporphyrin proved to be devoid of global aromatic character, but upon protonation aromatic mono- and dicationic species were generated. In the proton NMR spectrum for the dication, the internal CH was shifted upfield to approximately +3 ppm. NICS calculations and ACID plots confirmed the diatropic nature of these structures...
June 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28538610/diagnosis-treatment-and-surgical-repair-in-a-case-of-isolated-conjunctival-lichen-planus-causing-cicatricial-entropion
#12
Elizabeth A Cretara, Robert T Swan, Robert H Hill
A 50-year-old male presented with bilateral cicatricial entropion with subepithelial fibrosis and fornix foreshortening. Conjunctival biopsy showed lymphocytic infiltrate along the interface of the epithelium and lamina propria with linear, shaggy fibrinogen deposition along the epithelial basement membrane zone, supporting a diagnosis of lichen planus. The patient was treated with commercially available topical cyclosporine for 5 months after which bilateral lower eyelid splitting procedure with recession of the anterior lamella and complete excision of the lower eyelid lashes was performed...
May 22, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28484069/physician-perceptions-of-surveillance-follow-up-colonoscopy-in-older-adults
#13
Stephanie T Le, Brenna R Lash, Paul C Schroy, Audrey H Calderwood
BACKGROUND: Few data exist regarding when to stop surveillance colonoscopy among older adults with a history of adenomatous colorectal polyps. Our goal was to understand decision making around surveillance colonoscopy among primary care providers (PCPs) and gastroenterologists. METHODS: We designed a 15-item survey for PCPs and gastroenterologists that evaluated factors important in decision making about surveillance colonoscopy in older adults. RESULTS: In October 2015, 88 PCPs and 30 gastroenterologists completed the survey...
May 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28460838/editorial
#14
EDITORIAL
Gendie E Lash
No abstract text is available yet for this article.
April 27, 2017: Placenta
https://www.readbyqxmd.com/read/28456431/ifpa-meeting-2016-workshop-report-iii-decidua-trophoblast-interactions-trophoblast-implantation-and-invasion-immunology-at-the-maternal-fetal-interface-placental-inflammation
#15
John D Aplin, Alexander Beristain, Sonia DaSilva-Arnold, Caroline Dunk, Christina Duzyj, Thaddeus G Golos, Ulrike Kemmerling, Martin Knöfler, Murray D Mitchell, David M Olson, Margaret Petroff, Jürgen Pollheimer, Leticia Reyes, Pepper Schedin, Michael J Soares, Jennifer Stencel-Baerenwald, Kent L Thornburg, Gendie E Lash
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of decidual-trophoblast interaction, regulation of trophoblast invasion, immune cells at the maternal-fetal interface, and placental inflammation.
April 25, 2017: Placenta
https://www.readbyqxmd.com/read/28444108/racial-ethnic-differences-in-left-ventricular-structure-and-function-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort
#16
Faraz S Ahmad, Xuan Cai, Katherine Kunkel, Ana C Ricardo, James P Lash, Dominic S Raj, Jiang He, Amanda H Anderson, Matthew J Budoff, Julie A Wright Nunes, Jason Roy, Jackson T Wright, Alan S Go, Martin G St John Sutton, John W Kusek, Tamara Isakova, Myles Wolf, Martin G Keane
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD) and it is especially common among Blacks. Left ventricular hypertrophy (LVH) is an important subclinical marker of CVD, but there are limited data on racial variation in left ventricular structure and function among persons with CKD. METHODS: In a cross-sectional analysis of the Chronic Renal Insufficiency Cohort Study, we compared the prevalence of different types of left ventricular remodeling (concentric hypertrophy, eccentric hypertrophy, and concentric remodeling) by race/ethnicity...
April 24, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28438414/predictors-of-trachomatous-trichiasis-surgery-outcome
#17
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Bizuayehu Gashaw, Guadie S Wondimagegn, Hiwot D Mengistie, Saul N Rajak, Kelly Callahan, Helen A Weiss, Matthew J Burton
PURPOSE: Unfavorable outcomes after trachomatous trichiasis (TT) surgery are undermining the global trachoma elimination effort. This analysis investigates predictors of postoperative TT (PTT), eyelid contour abnormalities (ECAs), and granuloma in the 2 most common TT surgery procedures: posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR). DESIGN: Secondary data analysis from a randomized, controlled, single-masked clinical trial. PARTICIPANTS: A total of 1000 patients with TT, with lashes touching the eye or evidence of epilation, in association with tarsal conjunctival scarring...
August 2017: Ophthalmology
https://www.readbyqxmd.com/read/28430833/on-the-need-for-quantitative-bias-analysis-in-the-peer-review-process
#18
Matthew P Fox, Timothy L Lash
Peer review is central to the process through which epidemiologists generate evidence to inform public health and medical interventions. Reviewers thereby act as critical gatekeepers to high-quality research. They are asked to carefully consider the validity of the proposed work or research findings by paying careful attention to the methodology and critiquing the importance of the insight gained. However, although many have noted problems with the peer-review system for both manuscripts and grant submissions, few solutions have been proposed to improve the process...
May 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28429466/psychosocial-outcomes-in-active-treatment-through-survivorship
#19
Sarah C Reed, Janice F Bell, Robin Whitney, Rebecca Lash, Katherine K Kim, Richard J Bold, Jill G Joseph
OBJECTIVE: To understand potential differences in psychosocial outcomes from active treatment to survivorship. METHODS: Using the Medical Expenditure Panel Survey Experiences with Cancer Survivorship Supplement (n = 1,360) we examined and compared psychosocial outcomes among respondents in active treatment with survivors by year(s) since treatment ended. Survey-weighted regression models were used to test associations between year(s) since treatment and depressive symptoms (PHQ-2), psychological distress (K-6) and cancer-specific worry related to recurrence...
April 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28415266/cavitation-and-spallation-in-liquid-metal-droplets-produced-by-subpicosecond-pulsed-laser-radiation
#20
M S Krivokorytov, A Yu Vinokhodov, Yu V Sidelnikov, V M Krivtsun, V O Kompanets, A A Lash, K N Koshelev, V V Medvedev
The deformation and fragmentation of liquid metal microdroplets by intense subpicosecond Ti:sapphire laser pulses is experimentally studied with stroboscopic shadow photography. The experiments are performed at a peak intensity of 10^{14}W/cm^{2} at the target's surface, which produces shock waves with pressures in the Mbar range. As a result of such a strong impact, the droplet is transformed into a complex-shaped hollow structure that undergoes asymmetrical expansion and eventually fragments. The hollow structure of the expanding target is explained by the effects of cavitation and spallation that follow the propagation of the laser-induced shock wave...
March 2017: Physical Review. E
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