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https://www.readbyqxmd.com/read/29023240/correspondence-between-results-and-aims-of-funding-support-in-epidemiology-papers
#1
Timothy L Lash, Jay S Kaufman, Miguel A Hernán
No abstract text is available yet for this article.
October 11, 2017: Epidemiology
https://www.readbyqxmd.com/read/29021322/influence-of-baseline-diastolic-blood-pressure-on-effects-of-intensive-compared-to-standard-blood-pressure-control
#2
Srinivasan Beddhu, Glenn M Chertow, Alfred K Cheung, William C Cushman, Mahboob Rahman, Tom Greene, Guo Wei, Ruth C Campbell, Margaret Conroy, Barry I Freedman, William E Haley, Edward J Horwitz, Dalane W Kitzman, James Lash, Vasilios Papademetriou, Roberto Pisoni, Erik Riessen, Clive Rosendorff, Suzanne G Watnick, Jeff Whittle, Paul K Whelton
Background -In individuals with a low diastolic blood pressure (DBP), potential benefits or risks of intensive systolic blood pressure (SBP) lowering are unclear. Methods -The Systolic Blood Pressure Intervention Trial was a randomized, controlled trial that compared the effects of intensive (target <120 mm Hg) versus standard (target <140 mm Hg) SBP control in 9361 older adults with high blood pressure at increased risk of cardiovascular disease (CVD). The primary outcome was a composite of CVD events...
October 11, 2017: Circulation
https://www.readbyqxmd.com/read/28985268/clinical-outcomes-by-race-and-ethnicity-in-the-systolic-blood-pressure-intervention-trial-sprint-a-randomized-clinical-trial
#3
Carolyn H Still, Carlos J Rodriguez, Jackson T Wright, Timothy E Craven, Adam P Bress, Glenn M Chertow, Paul K Whelton, Jeffrey C Whittle, Barry I Freedman, Karen C Johnson, Capri G Foy, Jiang He, John B Kostis, James P Lash, Carolyn F Pedley, Roberto Pisoni, James R Powell, Barry M Wall
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) showed that targeting a systolic blood pressure (SBP) of ≤ 120 mm Hg (intensive treatment) reduced cardiovascular disease (CVD) events compared to SBP of ≤ 140 mm Hg (standard treatment); however, it is unclear if this effect is similar in all racial/ethnic groups. METHODS: We analyzed SPRINT data within non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic subgroups to address this question...
August 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28981813/rickettsia-parkeri-rickettsiales-rickettsiaceae-detected-in-ticks-of-the-amblyomma-maculatum-acari-ixodidae-group-collected-from-multiple-locations-in-southern-arizona
#4
Michelle E J Allerdice, Lorenza Beati, Hayley Yaglom, R Ryan Lash, Jesus Delgado-de la Mora, Jesus D Licona-Enriquez, David Delgado-de la Mora, Christopher D Paddock
Rickettsia parkeri is an emerging human pathogen transmitted by Amblyomma ticks in predominately tropical and subtropical regions of the western hemisphere. In 2014 and 2015, one confirmed case and one probable case of R. parkeri rickettsiosis were reported from the Pajarita Wilderness Area, a semi-arid mountainous region in southern Arizona. To examine more closely the potential public health risk of R. parkeri in this region, a study was initiated to investigate the pervasiveness of Amblyomma maculatum Koch group ticks in mountainous areas of southern Arizona and to ascertain the infection frequencies of R...
July 24, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28938715/the-harm-done-to-reproducibility-by-the-culture-of-null-hypothesis-significance-testing
#5
Timothy L Lash
In the last few years, stakeholders in the scientific community have raised alarms about a perceived lack of reproducibility of scientific results. In reaction, guidelines for journals have been promulgated and grant applicants have been asked to address the rigor and reproducibility of their proposed projects. Neither solution addresses a primary culprit, which is the culture of null hypothesis significance testing that dominates statistical analysis and inference. In an innovative research enterprise, selection of results for further evaluation based on null hypothesis significance testing is doomed to yield a low proportion of reproducible results and a high proportion of effects that are initially overestimated...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938714/lash-responds-to-is-reproducibility-thwarted-by-hypothesis-testing-and-the-need-for-cognitive-science-in-methodology
#6
Timothy L Lash
No abstract text is available yet for this article.
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938713/invited-commentary-can-issues-with-reproducibility-in-science-be-blamed-on-hypothesis-testing
#7
Clarice R Weinberg
In the accompanying article (Am J Epidemiol. 2017;186(6):646-647), Dr. Timothy Lash makes a forceful case that the problems with reproducibility in science stem from our "culture" of null hypothesis significance testing. He notes that when attention is selectively given to statistically significant findings, the estimated effects will be systematically biased away from the null. Here I revisit the recent history of genetic epidemiology and argue for retaining statistical testing as an important part of the tool kit...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28912373/the-association-of-sleep-duration-and-quality-with-ckd-progression
#8
Ana C Ricardo, Kristen Knutson, Jinsong Chen, Lawrence J Appel, Lydia Bazzano, Eunice Carmona-Powell, Janet Cohan, Manjula Kurella Tamura, Susan Steigerwalt, John Daryl Thornton, Matthew Weir, Nicolas F Turek, Mahboob Rahman, Eve Van Cauter, James P Lash
Evidence suggests that sleep disorders are common in individuals with CKD, but the influence of sleep duration and quality on CKD progression is unknown. We examined the association of habitual sleep duration and quality with CKD progression in 431 Chronic Renal Insufficiency Cohort (CRIC) Study participants, of whom 48% were women and 50% had diabetes (mean age of 60 years old, mean eGFR =38 ml/min per 1.73 m(2), and median urine protein-to-creatinine ratio [UPCR] =0.20 g/g). We assessed sleep duration and quality by 5-7 days of wrist actigraphy and self-report...
September 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28885417/association-of-nonsteroidal-antiinflammatory-drugs-and-postpartum-hypertension-in-women-with-preeclampsia-with-severe-features
#9
Oscar A Viteri, Joey A England, Mesk A Alrais, Kayla A Lash, Maria I Villegas, Olaide A Ashimi Balogun, Suneet P Chauhan, Baha M Sibai
OBJECTIVE: To estimate whether nonsteroidal antiinflammatory drugs (NSAIDs) are associated with persistent postpartum hypertension in a cohort of women with preeclampsia and severe features. METHODS: We conducted a retrospective cohort study at a single, tertiary center from January 2013 to December 2015. All women diagnosed with severe preeclampsia who remained hypertensive for greater than 24 hours after delivery were included. The primary outcome was the rate of persistent postpartum hypertension, defined as systolic blood pressure 150 mm Hg or greater or diastolic 100 mm Hg or greater (or both), on two occasions, at least 4 hours apart...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28872863/metalation-and-selective-oxidation-of-diphenyl-23-oxa-thia-and-selena-21-carbaporphyrins
#10
Timothy D Lash, Gregory M Ferrence
The availability of diphenyl-23-oxa-, -thia-, and -selena-21-carbaporphyrins has enabled the reactivity of these systems to be investigated and contrasted. All three heterocarbaporphyrins reacted with palladium(II) acetate in refluxing chloroform-acetonitrile to give organometallic palladium(II) derivatives in good yields. These structures are stable and give UV-vis spectra that show increasing broadening and bathochromic shifts as the size of the heteroatom increases. Nickel(II) acetate in refluxing N,N-dimethylformamide reacted with the oxa- and thiacarbaporphyrins under nitrogen to give the corresponding nickel(II) complexes, but the selenacarbaporphyrin did not metalate under these conditions...
September 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28869987/effects-of-intensive-systolic-blood-pressure-control-on-kidney-and-cardiovascular-outcomes-in-persons-without-kidney-disease-a-secondary-analysis-of-a-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
Srinivasan Beddhu, Michael V Rocco, Robert Toto, Timothy E Craven, Tom Greene, Udayan Bhatt, Alfred K Cheung, Debbie Cohen, Barry I Freedman, Amret T Hawfield, Anthony A Killeen, Paul L Kimmel, James Lash, Vasilios Papademetriou, Mahboob Rahman, Anjay Rastogi, Karen Servilla, Raymond R Townsend, Barry Wall, Paul K Whelton
Background: The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear. Objective: To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects. Design: Subgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). (ClinicalTrials.gov: NCT01206062)...
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28860915/congenital-distichiasis-histopathological-report-of-3-cases
#12
Hind Manaa Alkatan, Alicia Galindo-Ferreiro, Azza Maktabi, Alberto Galvez-Ruiz, Silvana Schellini
Distichiasis is a condition clinically presenting as partial or complete accessory row of lashes that emerges from the meibomian glands orifices. It can be an acquired or congenital with an autosomal dominant inheritance. The histopathological features are not well described in the ophthalmic literature, however they include abnormal pilosebaceous units within the posterior lamella of the eyelid and perifollicular chronic inflammatory cell infiltration. In this report, we describe the histopathological findings of three congenital distichiasis cases treated at King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia with discussion on the pathogenesis of such a condition and the differentiating features from ectopic cilia...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28858828/arsenic-and-obesity-a-comparison-of-urine-dilution-adjustment-methods
#13
Catherine M Bulka, Sithembile L Mabila, James P Lash, Mary E Turyk, Maria Argos
INTRODUCTION: A commonly used approach to adjust for urine dilution in analyses of biomarkers is to adjust for urinary creatinine. However, creatinine is a product of muscle mass and is therefore associated with body mass. In studies of urinary analytes and obesity or obesity-related outcomes, controlling for creatinine could induce collider stratification bias. We illustrate this phenomenon with an analysis of urinary arsenic. OBJECTIVE: We aimed to evaluate various approaches of adjustment for urinary dilution on the associations between urinary arsenic concentration and measures of obesity...
August 28, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28844984/epidermal-growth-factor-and-tumor-necrosis-factor-%C3%AE-cooperatively-promote-the-motility-of-hepatocellular-carcinoma-cell-lines-via-synergistic-induction-of-fibronectin-by-nf-%C3%AE%C2%BAb-p65
#14
Zong-Cai Liu, Fen Ning, Hai-Fang Wang, Dan-Yang Chen, Yan-Na Cai, Hui-Ying Sheng, Gendie E Lash, Li Liu, Jun Du
BACKGROUND: The interaction between hepatocellular carcinoma (HCC) cells and their microenvironment plays a fundamental role in tumor metastasis. The HCC microenvironment is rich in epidermal growth factor (EGF) and tumor necrosis factor α (TNFα), which may cooperatively, rather than individually, interact with tumor cells to influence their biological behavior. METHODS: Immunohistochemistry was performed to study the expression of EGF and TNFα in HCCs. Western blotting, immunofluorescence, qRT-PCR, wound healing scratch and invasion assay, and chromatin immunoprecipitation assays were used to study the combined roles of EGF and TNFα in the motility of HCC cells in vitro...
November 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28838919/lipoprotein-a-and-risk-of-myocardial-infarction-and-death-in-chronic-kidney-disease-findings-from-the-cric-study-chronic-renal-insufficiency-cohort
#15
Archna Bajaj, Scott M Damrauer, Amanda H Anderson, Dawei Xie, Matthew J Budoff, Alan S Go, Jiang He, James P Lash, Akinlolu Ojo, Wendy S Post, Mahboob Rahman, Muredach P Reilly, Danish Saleheen, Raymond R Townsend, Jinbo Chen, Daniel J Rader
OBJECTIVE: To investigate the effect of LPA gene variants and renal function on lipoprotein(a) [Lp(a)] levels in people with chronic kidney disease and determine the association between elevated Lp(a) and myocardial infarction and death in this setting. APPROACH AND RESULTS: The CRIC Study (Chronic Renal Insufficiency Cohort) is an ongoing prospective study of 3939 participants with chronic kidney disease. In 3635 CRIC participants with genotype data, carriers of the rs10455872 or rs6930542 variants had a higher median Lp(a) level (mg/dL) compared with noncarriers (73 versus 23; P<0...
October 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28836277/the-risk-of-preterm-birth-and-growth-restriction-in-pregnancy-after-cancer
#16
Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education...
August 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28819268/heterogenous-oceanic-redox-conditions-through-the-ediacaran-cambrian-boundary-limited-the-metazoan-zonation
#17
Junpeng Zhang, Tailiang Fan, Yuandong Zhang, Gary G Lash, Yifan Li, Yue Wu
Recent studies have enhanced our understanding of the linkage of oxygenation and metazoan evolution in Early Cambrian time. However, little of this work has addressed the apparent lag of animal diversification and atmospheric oxygenation during this critical period of Earth history. This study utilizes the geochemical proxy and N isotope record of the Ediacaran-Cambrian boundary preserved in intra-shelf basin, slope, and slope basin deposits of the Yangtze Sea to assess the ocean redox state during the Early Cambrian metazoan radiation...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811297/patterns-of-nsaids-use-and-their-association-with-other-analgesic-use-in-ckd
#18
Min Zhan, Wendy L St Peter, Rebecca M Doerfler, Corinne M Woods, Jacob B Blumenthal, Clarissa J Diamantidis, Chi-Yuan Hsu, James P Lash, Eva Lustigova, Erin B Mahone, Akinlolu O Ojo, Anne Slaven, Louise Strauss, Jonathan J Taliercio, Wolfgang C Winkelmayer, Dawei Xie, Jeffery C Fink
BACKGROUND AND OBJECTIVES: Avoiding nonsteroidal anti-inflammatory drugs is important for safe CKD care. This study examined nonsteroidal anti-inflammatory drug use patterns and their association with other analgesic use in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Chronic Renal Insufficiency Cohort Study is an observational cohort study that enrolled 3939 adults ages 21-74 years old with CKD between 2003 and 2008 using age-based eGFR inclusion criteria...
August 15, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28798474/cyp2c19-2-and-cyp2c19-17-variants-and-effect-of-tamoxifen-on-breast-cancer-recurrence-analysis-of-the-international-tamoxifen-pharmacogenomics-consortium-dataset
#19
Per Damkier, Anders Kjærsgaard, Kimberly A Barker, Deidre Cronin-Fenton, Anatasha Crawford, Ylva Hellberg, Emilius A M Janssen, Carl Langefeld, Thomas P Ahern, Timothy L Lash
The role of cytochrome P450 drug metabolizing enzymes in the efficacy of tamoxifen treatment of breast cancer is subject to substantial interest and controversy. CYP2D6 have been intensively studied, but the role of CYP2C19 is less elucidated, and we studied the association of CYPC19 genotype and recurrence of breast cancer. We used outcome and genotyping data from the large publicly available International Tamoxifen Pharmacogenomics Consortium (ITPC) dataset. Cox regression was used to compute the hazard ratios (HRs) for recurrence...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780974/cohort-study-of-cancer-risk-among-insured-transgender-people
#20
Michael J Silverberg, Rebecca Nash, Tracy A Becerra-Culqui, Lee Cromwell, Darios Getahun, Enid Hunkeler, Timothy L Lash, Andrea Millman, Virginia P Quinn, Brandi Robinson, Douglas Roblin, Jennifer Slovis, Vin Tangpricha, Michael Goodman
No abstract text is available yet for this article.
August 2017: Annals of Epidemiology
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