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https://www.readbyqxmd.com/read/29661941/mental-health-of-transgender-and-gender-nonconforming-youth-compared-with-their-peers
#1
Tracy A Becerra-Culqui, Yuan Liu, Rebecca Nash, Lee Cromwell, W Dana Flanders, Darios Getahun, Shawn V Giammattei, Enid M Hunkeler, Timothy L Lash, Andrea Millman, Virginia P Quinn, Brandi Robinson, Douglas Roblin, David E Sandberg, Michael J Silverberg, Vin Tangpricha, Michael Goodman
BACKGROUND: Understanding the magnitude of mental health problems, particularly life-threatening ones, experienced by transgender and/or gender nonconforming (TGNC) youth can lead to improved management of these conditions. METHODS: Electronic medical records were used to identify a cohort of 588 transfeminine and 745 transmasculine children (3-9 years old) and adolescents (10-17 years old) enrolled in integrated health care systems in California and Georgia. Ten male and 10 female referent cisgender enrollees were matched to each TGNC individual on year of birth, race and/or ethnicity, study site, and membership year of the index date (first evidence of gender nonconforming status)...
April 16, 2018: Pediatrics
https://www.readbyqxmd.com/read/29661541/ckd-and-esrd-in-us-hispanics
#2
REVIEW
Nisa Desai, Claudia M Lora, James P Lash, Ana C Ricardo
Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among Hispanics. Furthermore, Hispanic ethnicity has been associated with a greater prevalence of cardiovascular disease risk factors, including obesity and diabetes, as well as CKD-related complications...
April 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29628359/gene-expression-phenotype-associations-in-adults-with-eosinophilic-esophagitis
#3
Evan S Dellon, Sara R Selitsky, Robert M Genta, Richard H Lash, Joel S Parker
BACKGROUND: Gene expression patterns have not been extensively examined in the context of clinical features of eosinophilic esophagitis (EoE). AIMS: To assess whether gene expression is associated with clinically defined phenotypes in adults with EoE. METHODS: This was an analysis of prospectively collected esophageal biopsies in newly diagnosed EoE patients. We determined differential gene expression with a 94 gene panel in relation to clinical features and phenotypes...
March 27, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29608884/detection-of-mutations-in-barrett-s-esophagus-before-progression-to-high-grade-dysplasia-or-adenocarcinoma
#4
Matthew D Stachler, Nicholas D Camarda, Christopher Deitrick, Anthony Kim, Agoston T Agoston, Robert D Odze, Jason L Hornick, Anwesha Nag, Aaron R Thorner, Matthew Ducar, Amy Noffsinger, Richard H Lash, Mark Redston, Scott L Carter, Jon M Davison, Adam J Bass
BACKGROUND & AIMS: Barrett's esophagus (BE) is the greatest risk factor for esophageal adenocarcinoma, but only a small proportion of patients with BE develop cancer. Biomarkers might be able to identify patients at highest risk of progression. We investigated genomic differences in surveillance biopsies collected from patients whose BE subsequently progressed compared to patients whose disease did not progress. METHODS: We performed a retrospective case-control study of 24 patients with BE that progressed to high-grade dysplasia (HGD, n=14) or esophageal adenocarcinoma (EAC, n=10)...
March 30, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29595064/accelerating-drug-development-in-pediatric-cancer-a-novel-phase-i-study-design-of-venetoclax-in-relapsed-refractory-malignancies
#5
Andrew E Place, Kelly Goldsmith, Jean-Pierre Bourquin, Mignon L Loh, Lia Gore, Daniel A Morgenstern, Yeshwant Sanzgiri, David Hoffman, Ying Zhou, Jeremy A Ross, Betty Prine, Mohamad Shebley, Megan McNamee, Thalia Farazi, Su Young Kim, Maria Verdugo, Leanne Lash-Fleming, C Michel Zwaan, Josef Vormoor
Venetoclax is a highly selective, potent BCL-2 inhibitor that is approved for some patients previously treated for chronic lymphocytic leukemia, and has shown promising activity in adult studies across several hematologic malignancies. Preclinical studies have demonstrated venetoclax activity in pediatric patient-derived xenograft models and cell lines; however, clinical studies in pediatric patients have yet to be conducted. The prognosis is poor for children with most relapsed/refractory malignancies, and limited treatment options result in unmet clinical need...
March 29, 2018: Future Oncology
https://www.readbyqxmd.com/read/29593009/stanniocalcin-expression-as-a-predictor-of-late-breast-cancer-recurrence
#6
Kristen D Brantley, Anders Kjærsgaard, Deirdre Cronin-Fenton, Rami Yacoub, Anja S Nielsen, Kristina L Lauridsen, Stephen Hamilton-Dutoit, Timothy L Lash
BACKGROUND: Expression of human paracrine hormones stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) may potentiate late breast cancer recurrence. We tested the hypothesis that expression of STC1 and STC2 in primary breast tumors is more strongly associated with late versus early recurrences. METHODS: 541 estrogen receptor positive, tamoxifen treated (ER+/TAM+) and 300 estrogen receptor negative, tamoxifen untreated (ER-/TAM-) breast cancer patients who experienced recurrence within ten years of primary diagnosis and matched recurrence-free controls were selected from a cohort of 11,251 Danish breast cancer patients diagnosed with stage I, II, or III breast cancer during 1985-2001...
March 28, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29582826/actinomycetes-canaliculitis-complicating-congenital-nasolacrimal-duct-obstruction-in-an-infant
#7
Akshay Gopinathan Nair, Nayana A Potdar, Swaranjali S Gore, Amol Y Ganvir, Monisha K Apte, Trupti R Marathe, Chaya A Kumar, Chhaya A Shinde
Actinomyces israelii is a Gram-positive anaerobic organism commonly associated with canaliculitis in adults. Pediatric canaliculitis is relatively rare, especially in infancy. We report the case of an 11-month-old boy who presented with co-existing canaliculitis and congenital nasolacrimal obstruction. The presenting signs included epiphora, discharge, conjunctival congestion, and matting of lashes. On examination, punctual pouting, regurgitation, and yellow canaliculiths were noted. A punctoplasty and canalicular curettage were performed along with nasolacrimal probing...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580660/ckd-self-management-phenotypes-and-associations-with-clinical-outcomes
#8
Sarah J Schrauben, Jesse Y Hsu, Sylvia E Rosas, Bernard G Jaar, Xiaoming Zhang, Rajat Deo, Georges Saab, Jing Chen, Swati Lederer, Radhika Kanthety, L Lee Hamm, Ana C Ricardo, James P Lash, Harold I Feldman, Amanda H Anderson
BACKGROUND: To slow chronic kidney disease (CKD) progression and its complications, patients need to engage in self-management behaviors. The objective of this study was to classify CKD self-management behaviors into phenotypes and assess the association of these phenotypes with clinical outcomes. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Adults with mild to moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study...
March 24, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29579271/interleukin-34-is-present-at-the-fetal-maternal-interface-and-induces-immunoregulatory-macrophages-of-a-decidual-phenotype-in-vitro
#9
R Lindau, R B Mehta, G E Lash, G Papapavlou, R Boij, G Berg, M C Jenmalm, J Ernerudh, J Svensson-Arvelund
STUDY QUESTION: Is the newly discovered cytokine interleukin (IL)-34 expressed at the human fetal-maternal interface in order to influence polarization of monocytes into macrophages of a decidual immunoregulatory phenotype? SUMMARY ANSWER: IL-34 was found to be present at the fetal-maternal interface, in both fetal placenta and maternal decidua, and it was able to polarize monocytes into macrophages of a decidual phenotype. WHAT IS KNOWN ALREADY: IL-34 was shown to bind to the same receptor as macrophage-colony stimulating factor (M-CSF), which has an important immunomodulatory role at the fetal-maternal interface, for example by polarizing decidual macrophages to an M2-like regulatory phenotype...
April 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29537396/simplifying-research-access-to-genomics-and-health-data-with-library-cards
#10
Moran N Cabili, Knox Carey, Stephanie O M Dyke, Anthony J Brookes, Marc Fiume, Francis Jeanson, Giselle Kerry, Alex Lash, Heidi Sofia, Dylan Spalding, Anne-Marie Tasse, Susheel Varma, Ravi Pandya
The volume of genomics and health data is growing rapidly, driven by sequencing for both research and clinical use. However, under current practices, the data is fragmented into many distinct datasets, and researchers must go through a separate application process for each dataset. This is time-consuming both for the researchers and the data stewards, and it reduces the velocity of research and new discoveries that could improve human health. We propose to simplify this process, by introducing a standard Library Card that identifies and authenticates researchers across all participating datasets...
March 14, 2018: Scientific Data
https://www.readbyqxmd.com/read/29532509/successful-placement-of-nasointestinal-feeding-tubes-using-electromagnetic-sensor-guided-enteral-access-systems-in-patients-with-left-ventricular-assist-devices
#11
Kay Lash, Rachelle Oppel, Jeanette Hasse
Technology advances have made it possible to prolong life for patients with heart failure who are not transplant candidates or while awaiting transplant. Many different cardiac devices are available that can be used as a bridge to transplant (temporary support) or as a destination therapy (permanent support). Placement of these devices can cause complications that, if not addressed, could negatively impact the nutrition status of patients. Placement of nasointestinal feeding tubes using an electromagnetic sensor-guided enteral access system (EMS-EAS) has been difficult in patients with implantable devices because of the potential for interference with the EMS-EAS and the left ventricular assist device (LVAD)...
March 12, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29519605/time-driven-activity-based-cost-comparison-of-prostate-cancer-brachytherapy-and-intensity-modulated-radiation-therapy
#12
Sunil W Dutta, Kristine Bauer-Nilsen, Jason C Sanders, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery cost of frequently used radiotherapy options offered to patients with intermediate- to high-risk prostate cancer using time-driven activity-based costing and compare the results with Medicare reimbursement and relative value units (RVUs). METHODS AND MATERIALS: Process maps were created to represent each step of prostate radiotherapy treatment at our institution. Salary data, equipment purchase costs, and consumable costs were factored into the cost analysis...
March 5, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29514249/preventing-hypoglycemia-in-type-2-diabetes
#13
Robert W Lash, Deborah O Lucas, Judit Illes
No abstract text is available yet for this article.
March 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29477464/the-eyes-have-it-influenza-virus-infection-beyond-the-respiratory-tract
#14
REVIEW
Jessica A Belser, R Ryan Lash, Shikha Garg, Terrence M Tumpey, Taronna R Maines
Avian and human influenza A viruses alike have shown a capacity to use the eye as a portal of entry and cause ocular disease in human beings. However, whereas influenza viruses generally represent a respiratory pathogen and only occasionally cause ocular complications, the H7 virus subtype stands alone in possessing an ocular tropism. Clarifying what confers such non-respiratory tropism to a respiratory virus will permit a greater ability to identify, treat, and prevent zoonotic human infection following ocular exposure to influenza viruses; especially those within the H7 subtype, which continue to cause avian epidemics on many continents...
February 21, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29463478/association-between-gender-confirmation-treatments-and-perceived-gender-congruence-body-image-satisfaction-and-mental-health-in-a-cohort-of-transgender-individuals
#15
Ashli A Owen-Smith, Joseph Gerth, R Craig Sineath, Joshua Barzilay, Tracy A Becerra-Culqui, Darios Getahun, Shawn Giammattei, Enid Hunkeler, Timothy L Lash, Andrea Millman, Rebecca Nash, Virginia P Quinn, Brandi Robinson, Douglas Roblin, Travis Sanchez, Michael J Silverberg, Vin Tangpricha, Cadence Valentine, Savannah Winter, Cory Woodyatt, Yongjia Song, Michael Goodman
BACKGROUND: Transgender individuals sometimes seek gender confirmation treatments (GCT), including hormone therapy (HT) and/or surgical change of the chest and genitalia ("top" and "bottom" gender confirmation surgeries). These treatments may ameliorate distress resulting from the incongruence between one's physical appearance and gender identity. AIM: The aim was to examine the degree to which individuals' body-gender congruence, body image satisfaction, depression, and anxiety differed by GCT groups in cohorts of transmasculine (TM) and transfeminine (TF) individuals...
February 17, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29436067/identification-and-functional-analyses-of-differentially-expressed-metabolites-in-early-stage-endometrial-carcinoma
#16
Kun Shi, Qiong Wang, Yao Su, Xingcui Xuan, Yaqiong Liu, Weiwei Chen, Yuanmin Qian, Gendie E Lash
Diagnosis of endometrial cancer is primarily based on symptoms and imaging, with early-stage disease being difficult to diagnose. Therefore, development of potential diagnostic biomarkers is required. Metabolomics, a quantitative measurement of the dynamic metabolism in living systems, can be applied to determine metabolite profiles in different disease states. Here, serum metabolomics was performed in forty-six early stage endometrial cancer patients and forty-six healthy volunteers. In addition, the effect of identified metabolites on tumour cell behavior (invasion, migration, proliferation, apoptosis, autophagy), was examined in endometrial cancer cell lines...
February 12, 2018: Cancer Science
https://www.readbyqxmd.com/read/29434036/damaging-de-novo-mutations-diminish-motor-skills-in-children-on-the-autism-spectrum
#17
Andreas Buja, Natalia Volfovsky, Abba M Krieger, Catherine Lord, Alex E Lash, Michael Wigler, Ivan Iossifov
In individuals with autism spectrum disorder (ASD), de novo mutations have previously been shown to be significantly correlated with lower IQ but not with the core characteristics of ASD: deficits in social communication and interaction and restricted interests and repetitive patterns of behavior. We extend these findings by demonstrating in the Simons Simplex Collection that damaging de novo mutations in ASD individuals are also significantly and convincingly correlated with measures of impaired motor skills...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29430714/concomitant-lipomatous-hypertrophy-and-left-atrial-mass-distinguishing-benign-from-malignant
#18
Amanda M Kleiman, Lindsay M Harding, Allison J Bechtel
Masses in and near the interatrial septum may be either benign or malignant. The most common mass near the interatrial septum is lipomatous atrial septal hypertrophy (LASH). LASH can be present in patients with intracardiac malignancies, myxomas, lipomas, or other cardiac masses. It is important to recognize the transesophageal echocardiography (TEE) characteristics of these pathologies to arrive at an accurate diagnosis with an appropriate plan for intraoperative resection. At the authors' institution, patients have been referred for surgery due to a finding of significant LASH masquerading as a left atrial myxoma...
February 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#19
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29403011/clcn2-chloride-channel-mutations-in-familial-hyperaldosteronism-type-ii
#20
Ute I Scholl, Gabriel Stölting, Julia Schewe, Anne Thiel, Hua Tan, Carol Nelson-Williams, Alfred A Vichot, Sheng Chih Jin, Erin Loring, Verena Untiet, Taekyeong Yoo, Jungmin Choi, Shengxin Xu, Aihua Wu, Marieluise Kirchner, Philipp Mertins, Lars C Rump, Ali Mirza Onder, Cory Gamble, Daniel McKenney, Robert W Lash, Deborah P Jones, Gary Chune, Priscila Gagliardi, Murim Choi, Richard Gordon, Michael Stowasser, Christoph Fahlke, Richard P Lifton
Primary aldosteronism, a common cause of severe hypertension1 , features constitutive production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial hyperaldosteronism type II (FH-II)2 and 80 additional probands with unsolved early-onset primary aldosteronism. Eight probands had novel heterozygous variants in CLCN2, including two de novo mutations and four independent occurrences of a mutation encoding an identical p.Arg172Gln substitution; all relatives with early-onset primary aldosteronism carried the CLCN2 variant found in the proband...
March 2018: Nature Genetics
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