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https://www.readbyqxmd.com/read/29202630/concurrent-new-drug-prescriptions-and-prognosis-of-early-breast-cancer-studies-using-the-danish-breast-cancer-group-clinical-database
#1
Deirdre Cronin-Fenton, Timothy L Lash, Thomas P Ahern, Per Damkier, Peer Christiansen, Bent Ejlertsen, Henrik T Sørensen
BACKGROUND: Myriad reports suggest that frequently used prescription drugs alter the viability of breast cancer cells in pre-clinical studies. Routine use of these drugs, therefore, may impact breast cancer prognosis, and could have important implications for public health. METHODS: The Danish Breast Cancer Group (DBCG) clinical database provides high-quality prospectively collected data on breast cancer diagnosis, treatment, and routine follow-up for breast cancer recurrence...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29183390/serum-concentrations-of-active-tamoxifen-metabolites-predict-long-term-survival-in-adjuvantly-treated-breast-cancer-patients
#2
Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen, Vessela N Kristensen, Jan T Kvaløy, Timothy L Lash, Grethe I G Alnæs, Ron H van Schaik, Emiel A M Janssen, Steinar Hustad, Ernst A Lien, Gunnar Mellgren, Håvard Søiland
BACKGROUND: Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement of concentrations of active tamoxifen metabolites in serum may be a more biological plausible and robust approach. We have investigated the association between CYP2D6 genotypes, serum concentrations of active tamoxifen metabolites, and long-term outcome in tamoxifen treated breast cancer patients...
November 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29181031/laparoscopic-supracervical-hysterectomy-with-in-bag-morcellation-in-very-large-uterus
#3
Harald Krentel, Rudy Leon De Wilde
Laparoscopic supracervical hysterectomy (LASH) is a safe and fast minimally invasive approach in hysterectomy. In order to extract the uterine body from the abdominal cavity, one condition for LASH is the morcellation of the tissue. The intra-abdominal dissemination of benign and occult malignant uterine cells is a possible risk of this method, which can be avoided by the use of special bags for laparoscopic in-bag morcellation. We present a case of laparoscopic supracervical hysterectomy with in-bag morcellation in a uterus of more than 1400 g...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29166302/hierarchical-semi-bayes-methods-for-misclassification-in-perinatal-epidemiology
#4
Richard F MacLehose, Lisa M Bodnar, Craig Meyer, Haitao Chu, Timothy L Lash
BACKGROUND: Validation data are used to estimate the extent of misclassification in epidemiologic studies. In the Penn MOMS cohort, prepregnancy BMI is subject to misclassification and validation data are available to estimate the extent of misclassification. We use these data to estimate the association between maternal prepregnancy body mass index and early preterm (<32 weeks) birth using a semi-Bayes hierarchical model allowing for more flexible adjustment for misclassification...
November 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/29162340/effects-of-intensive-blood-pressure-treatment-on-acute-kidney-injury-events-in-the-systolic-blood-pressure-intervention-trial-sprint
#5
Michael V Rocco, Kaycee M Sink, Laura C Lovato, Dawn F Wolfgram, Thomas B Wiegmann, Barry M Wall, Kausik Umanath, Frederic Rahbari-Oskoui, Anna C Porter, Roberto Pisoni, Cora E Lewis, Julia B Lewis, James P Lash, Lois A Katz, Amret T Hawfield, William E Haley, Barry I Freedman, Jamie P Dwyer, Paul E Drawz, Mirela Dobre, Alfred K Cheung, Ruth C Campbell, Udayan Bhatt, Srinivasan Beddhu, Paul L Kimmel, David M Reboussin, Glenn M Chertow
BACKGROUND: Treating to a lower blood pressure (BP) may increase acute kidney injury (AKI) events. STUDY DESIGN: Data for AKI resulting in or during hospitalization or emergency department visits were collected as part of the serious adverse events reporting process of the Systolic Blood Pressure Intervention Trial (SPRINT). SETTING & PARTICIPANTS: 9,361 participants 50 years or older with 1 or more risk factors for cardiovascular disease...
November 18, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29128682/randomized-double-masked-trial-of-eyelid-cleansing-treatments-for-blepharitis
#6
Justin Sung, Michael T M Wang, Sang H Lee, Isabella M Y Cheung, Salim Ismail, Trevor Sherwin, Jennifer P Craig
PURPOSE: To compare the efficacy of a dedicated eyelid cleanser and diluted baby shampoo in the management of blepharitis. METHODS: Forty-three participants with clinical blepharitis signs were enrolled in a prospective, randomized, double-masked, paired-eye trial. A dedicated eyelid cleanser (TheraTears® SteriLid®) was applied to the eyelids of one eye (randomized) and diluted baby shampoo (Johnson's® No More Tears®) to the fellow eye, twice daily for 4 weeks...
November 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29120958/best-antihypertensive-strategies-to-improve-blood-pressure-control-in-latin-america-position-of-the-latin-american-society-of-hypertension
#7
Antonio Coca, Patricio López-Jaramillo, Costas Thomopoulos, Alberto Zanchetti
: Evidence from randomized trials has shown that effective treatment with blood pressure (BP)-lowering medications reduces the risk of cardiovascular morbidity and mortality in patients with hypertension. Therefore, hypertension control and prevention of subsequent morbidity and mortality should be achievable for all patients worldwide. However, many people in Latin America remain undiagnosed, untreated or have inadequately controlled BP, even where this is access to health systems. Barriers to hypertension control in low-income countries include difficulties in transportation to health services; inappropriate opening hours; difficulties in making clinic appointments; inaccessible healthcare facilities, lack of insurance and high treatment costs...
November 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29079120/evaluation-of-delivery-costs-for-external-beam-radiation-therapy-and-brachytherapy-for-locally-advanced-cervical-cancer-using-time-driven-activity-based-costing
#8
Kristine Bauer-Nilsen, Colin Hill, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery costs, using time-driven activity-based costing, and reimbursement for definitive radiation therapy for locally advanced cervical cancer. METHODS AND MATERIALS: Process maps were created to represent each step of the radiation treatment process and included personnel, equipment, and consumable supplies used to deliver care. Personnel were interviewed to estimate time involved to deliver care. Salary data, equipment purchasing information, and facilities costs were also obtained...
September 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29068839/new-designs-for-new-epidemiology
#9
Timothy L Lash, Enrique F Schisterman
No abstract text is available yet for this article.
October 24, 2017: Epidemiology
https://www.readbyqxmd.com/read/29058522/a-new-surgical-technique-for-congenital-distichiasis
#10
Alicia Galindo-Ferreiro, Hind Alkatan, Azza Maktabi, Alberto Gálvez-Ruiz, Silvana Schellini
PURPOSE: To describe a new technique to treat congenital distichiasis. METHODS: Case series of three distichiatic patients undergoing a novel surgical technique combining splitting of the lid margin with the distichiatic lashes, marginal tarsectomy in the affected area, and tarsoconjunctival graft obtained from the upper region of the tarsus. The graft was sutured at the exposed region of the marginal tarsectomy. RESULTS: Good cosmesis was obtained in all cases and the lids margins healed completely with good surgical outcome and no lashes contacted the cornea postoperatively...
October 23, 2017: Orbit
https://www.readbyqxmd.com/read/29057381/association-of-sleep-duration-symptoms-and-disorders-with-mortality-in-adults-with-chronic-kidney-disease
#11
Ana C Ricardo, Vivien Goh, Jinsong Chen, Esteban Cedillo-Couvert, Mary Kapella, Bharati Prasad, Sharmila Parvathaneni, Kristen Knutson, James P Lash
INTRODUCTION: In general populations, short and long sleep duration, poor sleep quality and sleep disorders have been associated with increased risk of death. We evaluated these associations in individuals with chronic kidney disease (CKD). METHODS: Prospective cohort study of 1,452 National Health and Nutrition Examination Survey (NHANES) 2005-2008 participants with CKD. CKD was defined by estimated glomerular filtration rate <60 ml/min/1.73m(2) or urine albumin-to-creatinine ratio ≥30 mg/g...
September 2017: KI Reports
https://www.readbyqxmd.com/read/29055903/significant-correlation-between-meibomian-gland-dysfunction-and-keratitis-in-young-patients-with-demodex-brevis-infestation
#12
Lingyi Liang, Yan Liu, Xiaohu Ding, Hongmin Ke, Chuan Chen, Scheffer C G Tseng
AIMS: To report the clinical characteristics and correlation between meibomian gland dysfunction (MGD) and keratitis in young patients with ocular demodicosis. METHODS: Observational case series of 60 patients younger than 35 years with ocular demodicosis, of which the diagnosis was based on microscopic counting of Demodex folliculorum and D. brevis of epilated lashes. Severity of keratitis and MGD was graded by photography and meibography, respectively, in a masked fashion...
October 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29023240/correspondence-between-results-and-aims-of-funding-support-in-epidemiology-papers
#13
Timothy L Lash, Jay S Kaufman, Miguel A Hernán
No abstract text is available yet for this article.
October 11, 2017: Epidemiology
https://www.readbyqxmd.com/read/29021322/influence-of-baseline-diastolic-blood-pressure-on-effects-of-intensive-compared-to-standard-blood-pressure-control
#14
Srinivasan Beddhu, Glenn M Chertow, Alfred K Cheung, William C Cushman, Mahboob Rahman, Tom Greene, Guo Wei, Ruth C Campbell, Margaret Conroy, Barry I Freedman, William E Haley, Edward J Horwitz, Dalane W Kitzman, James Lash, Vasilios Papademetriou, Roberto Pisoni, Erik Riessen, Clive Rosendorff, Suzanne G Watnick, Jeff Whittle, Paul K Whelton
Background -In individuals with a low diastolic blood pressure (DBP), potential benefits or risks of intensive systolic blood pressure (SBP) lowering are unclear. Methods -The Systolic Blood Pressure Intervention Trial was a randomized, controlled trial that compared the effects of intensive (target <120 mm Hg) versus standard (target <140 mm Hg) SBP control in 9361 older adults with high blood pressure at increased risk of cardiovascular disease (CVD). The primary outcome was a composite of CVD events...
October 11, 2017: Circulation
https://www.readbyqxmd.com/read/28985268/clinical-outcomes-by-race-and-ethnicity-in-the-systolic-blood-pressure-intervention-trial-sprint-a-randomized-clinical-trial
#15
Carolyn H Still, Carlos J Rodriguez, Jackson T Wright, Timothy E Craven, Adam P Bress, Glenn M Chertow, Paul K Whelton, Jeffrey C Whittle, Barry I Freedman, Karen C Johnson, Capri G Foy, Jiang He, John B Kostis, James P Lash, Carolyn F Pedley, Roberto Pisoni, James R Powell, Barry M Wall
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) showed that targeting a systolic blood pressure (SBP) of ≤ 120 mm Hg (intensive treatment) reduced cardiovascular disease (CVD) events compared to SBP of ≤ 140 mm Hg (standard treatment); however, it is unclear if this effect is similar in all racial/ethnic groups. METHODS: We analyzed SPRINT data within non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic subgroups to address this question...
August 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28981813/rickettsia-parkeri-rickettsiales-rickettsiaceae-detected-in-ticks-of-the-amblyomma-maculatum-acari-ixodidae-group-collected-from-multiple-locations-in-southern-arizona
#16
Michelle E J Allerdice, Lorenza Beati, Hayley Yaglom, R Ryan Lash, Jesus Delgado-de la Mora, Jesus D Licona-Enriquez, David Delgado-de la Mora, Christopher D Paddock
Rickettsia parkeri is an emerging human pathogen transmitted by Amblyomma ticks in predominately tropical and subtropical regions of the western hemisphere. In 2014 and 2015, one confirmed case and one probable case of R. parkeri rickettsiosis were reported from the Pajarita Wilderness Area, a semi-arid mountainous region in southern Arizona. To examine more closely the potential public health risk of R. parkeri in this region, a study was initiated to investigate the pervasiveness of Amblyomma maculatum Koch group ticks in mountainous areas of southern Arizona and to ascertain the infection frequencies of R...
November 7, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28938715/the-harm-done-to-reproducibility-by-the-culture-of-null-hypothesis-significance-testing
#17
Timothy L Lash
In the last few years, stakeholders in the scientific community have raised alarms about a perceived lack of reproducibility of scientific results. In reaction, guidelines for journals have been promulgated and grant applicants have been asked to address the rigor and reproducibility of their proposed projects. Neither solution addresses a primary culprit, which is the culture of null hypothesis significance testing that dominates statistical analysis and inference. In an innovative research enterprise, selection of results for further evaluation based on null hypothesis significance testing is doomed to yield a low proportion of reproducible results and a high proportion of effects that are initially overestimated...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938714/lash-responds-to-is-reproducibility-thwarted-by-hypothesis-testing-and-the-need-for-cognitive-science-in-methodology
#18
Timothy L Lash
No abstract text is available yet for this article.
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938713/invited-commentary-can-issues-with-reproducibility-in-science-be-blamed-on-hypothesis-testing
#19
Clarice R Weinberg
In the accompanying article (Am J Epidemiol. 2017;186(6):646-647), Dr. Timothy Lash makes a forceful case that the problems with reproducibility in science stem from our "culture" of null hypothesis significance testing. He notes that when attention is selectively given to statistically significant findings, the estimated effects will be systematically biased away from the null. Here I revisit the recent history of genetic epidemiology and argue for retaining statistical testing as an important part of the tool kit...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28912373/the-association-of-sleep-duration-and-quality-with-ckd-progression
#20
Ana C Ricardo, Kristen Knutson, Jinsong Chen, Lawrence J Appel, Lydia Bazzano, Eunice Carmona-Powell, Janet Cohan, Manjula Kurella Tamura, Susan Steigerwalt, John Daryl Thornton, Matthew Weir, Nicolas F Turek, Mahboob Rahman, Eve Van Cauter, James P Lash
Evidence suggests that sleep disorders are common in individuals with CKD, but the influence of sleep duration and quality on CKD progression is unknown. We examined the association of habitual sleep duration and quality with CKD progression in 431 Chronic Renal Insufficiency Cohort (CRIC) Study participants, of whom 48% were women and 50% had diabetes (mean age of 60 years old, mean eGFR =38 ml/min per 1.73 m2, and median urine protein-to-creatinine ratio [UPCR] =0.20 g/g). We assessed sleep duration and quality by 5-7 days of wrist actigraphy and self-report...
September 14, 2017: Journal of the American Society of Nephrology: JASN
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