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ketamine oddball

Ulrich Schall, Bernhard W Müller, Christian Kärgel, Onur Güntürkün
The neural response to occasional variations in acoustic stimuli in a regular sequence of sounds generates an N-methyl-D-aspartate receptor-modulated event-related potential in primates and rodents in the primary auditory cortex known as mismatch negativity (MMN). The current study investigated MMN in pigeons (Columba livia L) through intracranial recordings from Field L of the caudomedial nidopallium, the avian functional equivalent of the mammalian primary auditory cortex. Auditory evoked field potentials were recorded from awake birds using a low-frequency (800 Hz) and high-frequency (1400 Hz) deviant auditory oddball procedure with deviant-as-standard (flip-flop design) and multiple-standard control conditions...
March 25, 2015: Neuroreport
Ricardo Gil-da-Costa, Gene R Stoner, Raynard Fung, Thomas D Albright
There is growing evidence that impaired sensory-processing significantly contributes to the cognitive deficits found in schizophrenia. For example, the mismatch negativity (MMN) and P3a event-related potentials (ERPs), neurophysiological indices of sensory and cognitive function, are reduced in schizophrenia patients and may be used as biomarkers of the disease. In agreement with glutamatergic theories of schizophrenia, NMDA antagonists, such as ketamine, elicit many symptoms of schizophrenia when administered to normal subjects, including reductions in the MMN and the P3a...
September 17, 2013: Proceedings of the National Academy of Sciences of the United States of America
Francesco Musso, Jürgen Brinkmeyer, Daniel Ecker, Markus K London, Giesela Thieme, Tracy Warbrick, Hans-Jörg Wittsack, Andreas Saleh, Wolfgang Greb, Peter de Boer, Georg Winterer
BACKGROUND: Behavioral and electrophysiological human ketamine models of schizophrenia are used for testing compounds that target the glutamatergic system. However, corresponding functional neuroimaging models are difficult to reconcile with functional imaging and electrophysiological findings in schizophrenia. Resolving the discrepancies between different observational levels is critical to understand the complex pharmacological ketamine action and its usefulness for modeling schizophrenia pathophysiology...
September 15, 2011: NeuroImage
Patrik Roser, Ida S Haussleiter, Hee-Jeong Chong, Christoph Maier, Wolfram Kawohl, Christine Norra, Georg Juckel
RATIONALE: Preclinical and clinical research suggests that the endogenous cannabinoid system is involved in cognitive impairments related to schizophrenia. In particular, the deficient generation of mismatch negativity (MMN) indicating auditory sensory memory is a characteristic finding in schizophrenic patients. Experimental studies implicate deficient N-methyl-D: -aspartate (NMDA) receptor functioning in such abnormalities. OBJECTIVES: The primary aim of this study was to investigate the effects of the cannabinoid CB(1) receptor antagonist rimonabant on MMN deficits in the NMDA receptor antagonist model of schizophrenia by using ketamine...
December 2011: Psychopharmacology
Todd D Watson, Ismene L Petrakis, Javon Edgecombe, Albert Perrino, John H Krystal, Daniel H Mathalon
In this double-blind, placebo-controlled study, we examined the effects of subanaesthetic doses of ketamine (an NMDA glutamate receptor antagonist) and thiopental (a GABA-A receptor agonist) on the event-related potential (ERP) correlates of deviant stimulus processing in 24 healthy adults. Participants completed three separate pharmacological challenge sessions (ketamine, thiopental, saline) in a counterbalanced order. EEG data were recorded both before and during each challenge while participants performed a visual 'oddball' task consisting of infrequent 'target' and 'novel' stimuli intermixed with frequent 'standard' stimuli...
April 2009: International Journal of Neuropsychopharmacology
Steven J Siegel, Patrick Connolly, Yuling Liang, Robert H Lenox, Raquel E Gur, Warren B Bilker, Steven J Kanes, Bruce I Turetsky
People with schizophrenia exhibit impaired ability to modify electroencephalographic event-related potential (ERP) responses to novel stimuli. These deficits serve as a window into the abnormalities of neuronal organization and function and are thought to reflect a component of genetic vulnerability for schizophrenia. We describe differences among inbred mouse strains for ERPs following a novelty detection paradigm, as a model for genetic contributions to disease vulnerability. Auditory-evoked potentials were recorded during an auditory oddball task in nonanesthetized C57BL/6J, C3H/HeJ, and DBA/2J mice prior to and following ketamine (10 mg/kg)...
April 2003: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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