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https://www.readbyqxmd.com/read/28930608/anti-tick-vaccines-in-the-omics-era
#1
Manuel Rodriguez Valle, Felix D Guerrero
Tick vaccines have been available for more than 20 years. They are useful and effective control agents when used properly. However, no new products have emerged since the Bm86-based Gavac vaccine was commercialized. Acaricide resistance is a problem with no abatement in sight and anti-tick vaccines are likely to be relied upon even more in the coming years. As human medicine and plant agriculture has embraced the various Omics technologies, the search for anti-tick vaccines would be well served to follow; so that new vaccine antigens and adjuvants might be developed to assist tick control programs...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930165/timeliness-of-childhood-primary-immunization-and-risk-factors-related-with-delays-evidence-from-the-2014-zhejiang-provincial-vaccination-coverage-survey
#2
Yu Hu, Qian Li, Yaping Chen
Background: this study aimed to assess both immunization coverage and timeliness, as well as reasons for non-vaccination, and identity the risk factors of delayed immunization, for the vaccines scheduled during the first year of life, in Zhejiang province, east China. Methods: A cluster survey among children aged 24-35 months was conducted. Demographic information and socio-economic characteristics of the selected child, the mother, and the household were collected. Immunization data were transcribed from immunization cards...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28929958/-screening-of-corynebacterium-diphtheriae-corynebacterium-ulcerans-and-corynebacterium-pseudotuberculosis-in-throat-swab-specimens-of-children-with-upper-respiratory-tract-infections
#3
Zeynep Gökçe Gayretli Aydın, Gönül Tanır, Selin Nar Ötgün, Meral Turan, Türkan Aydın Teke, Ayşe Kaman, Selçuk Kılıç
Although a significant decrease has been reported in the incidence of diphteria in many regions of the world following the routine diphtheria immunization programs, the emergence of new cases indicated that toxigenic strains are still circulating in the community. Diphtheria vaccine does not provide protection against asymptomatic carriage and colonization of non-toxigenic Corynebacterium diphtheriae. It is a known fact that invasive infections may arise from non-toxigenic C.diphtheriae strains that the non-toxigenic strains can become toxigenic strains leading to diphteria...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929957/-serotype-distribution-and-antibiotic-resistance-of-streptococcus-pneumoniae-strains-isolated-from-the-adult-patients-in-a-turkish-%C3%A3-niversity-hospital
#4
Lütfiye Öksüz, Nezahat Gürler
Infections caused by Streptococcus pneumoniae are the most important cause of morbidity and mortality worldwide. S.pneumoniae is the most common cause of community-acquired pneumonia, especially in adults. Invasive pneumococcal disease can usually occur in the elderly, children and immunocompromised individuals. Usage of the vaccines for the protection against S.pneumoniae infections, is an effective method to reduce the burden of disease in both children and adults. Serotypes frequently isolated from purified capsular polysaccharides of S...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28928954/rotavirus-vaccines-a-story-of-success-with-challenges-ahead
#5
REVIEW
Miguel O'Ryan
Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide. Currently, 92 countries have introduced rotavirus vaccines into national or subnational programs with evident impact in disease reduction. Two vaccines have been widely used, and four additional vaccines have been licensed and are being used in defined regions. In this context, one main issue that remains unsolved is the lower vaccine efficacy/effectiveness in low-income countries...
2017: F1000Research
https://www.readbyqxmd.com/read/28928078/a-nationwide-study-on-the-impact-of-pneumococcal-conjugate-vaccination-on-antibiotic-use-and-ventilation-tube-insertion-in-denmark-2000-2014
#6
Michael Frantz Howitz, Zitta Barrella Harboe, Helene Ingels, Palle Valentiner-Branth, Kåre Mølbak, Bjarki Ditlev Djurhuus
Introduction of Pneumococcal Conjugated Vaccines (PCV) in national immunization programs have been successful in reducing the number of invasive and lower respiratory pneumococcal infections. The impact of the vaccines on upper respiratory infections caused by pneumococci is less clear although these account for most pneumococcal infections. In this study, we used likely proxies for respiratory infections in children, such as antibiotic use and ventilation tube insertions (VTI), to estimate the impact of the vaccine on a national level...
September 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28927464/cervical-cancer-screening-behavior-and-associated-factors-among-women-of-ugrachandi-nala-kavre-nepal
#7
Radha Acharya Pandey, Era Karmacharya
BACKGROUND: Cervical cancer in Nepal ranks as the first most frequent cancer among women. Primary prevention measures, such as prophylactic vaccines against high risk HPV, are now available. Over time, vaccination will decrease the prevalence of the disease among younger women; however, screening will still be needed. The objective of the study was to assess the cervical cancer screening behavior and its associated factors among women of Nala Village Development Committee (VDC), Kavre...
September 19, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28925801/mf59-adjuvanted-influenza-vaccine-fluad%C3%A2-elicits-higher-immune-responses-than-a-non-adjuvanted-influenza-vaccine-fluzone%C3%A2-a-randomized-multicenter-phase-iii-pediatric-trial-in-mexico
#8
Aurelio Cruz-Valdez, Gabriel Valdez-Zapata, Sanjay S Patel, Flavia V Castelli, Marcia G Garcia, Wim T Jansen, Ashwani Kumar Arora, Esther Heijnen
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent influenza vaccine FLUAD® (aTIV) and a non-adjuvanted TIV, in healthy children (aged 6 to <72 months) from 3 centers in Mexico, during the 2014-2015 season. The primary objectives were to assess the non-inferiority of aTIV to TIV, measured by geometric mean titers (GMTs), and the safety of aTIV and TIV...
September 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28922613/the-etiology-of-community-acquired-pneumonia-among-children-under-5%C3%A2-years-of-age-in-mainland-china-2001-2015-a-systematic-review
#9
Guijun Ning, Xuxia Wang, Dan Wu, Zundong Yin, Yixing Li, Huaqing Wang, Weizhong Yang
BACKGROUND: The aim of this systematic review was to examine the etiology of community-acquired pneumonia (CAP) among Chinese children younger than 5 years and provide evidence for further cost-effectiveness analyses for vaccine development, diagnostic strategies and empirical treatments. METHODS: The literature review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data were obtained by searching PubMed, Embase, Web-of Science, and the Chinese databases Wanfang Data and China National Knowledge Infrastructure...
September 18, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28919225/a-comparative-cost-analysis-of-the-vaccination-program-for-us-bound-refugees
#10
Heesoo Joo, Brian Maskery, Tarissa Mitchell, Andrew Leidner, Alexander Klosovsky, Michelle Weinberg
BACKGROUND: Vaccination Program for US-bound Refugees (VPR) currently provides one or two doses of some age-specific Advisory Committee on Immunization Practices (ACIP)-recommended vaccines to US-bound refugees prior to departure. METHODS: We quantified and compared the full vaccination costs for refugees using two scenarios: (1) the baseline of no VPR and (2) the current situation with VPR. Under the first scenario, refugees would be fully vaccinated after arrival in the United States...
September 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#11
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28916742/haplotype-of-the-interleukin-17a-gene-is-associated-with-osteitis-after-bacillus-calmette-guerin-vaccination
#12
Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Eero Lauhkonen, Juho Vuononvirta, Kirsi Nuolivirta, Liisa Kröger, Laura Pöyhönen, Minna K Karjalainen, Qiushui He
Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis after newborn vaccination. IL17A rs4711998, rs8193036 and rs2275913 SNPs were determined in 131 adults had presented with BCG osteitis after newborn BCG vaccination...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915402/complete-immunization-coverage-and-its-determinants-among-children-in-malaysia-findings-from-the-national-health-and-morbidity-survey-nhms-2016
#13
K K Lim, Y Y Chan, A Noor Ani, J Rohani, Z A Siti Norfadhilah, M R Santhi
OBJECTIVES: The success of the Expanded Program on Immunization among children will greatly reduce the burden of illness and disability from vaccine preventable diseases. The aim of the study was to evaluate the complete immunization coverage and its determinants among children aged 12-23 months in Malaysia. STUDY DESIGN: Cross-sectional study. METHODS: Data on immunization were extracted from the 2016 National Health and Morbidity Survey...
September 12, 2017: Public Health
https://www.readbyqxmd.com/read/28914112/socioeconomic-differences-in-childhood-vaccination-in-developed-countries-a-systematic-review-of-quantitative-studies
#14
Aurélie Bocquier, Jeremy Ward, Jocelyn Raude, Patrick Peretti-Watel, Pierre Verger
Introduction The reasons for vaccine hesitancy and its relation to individual socioeconomic status (SES) must be better understood. Areas covered This review focused on developed countries with programs addressing major financial barriers to vaccination access. We systematically reviewed differences by SES in uptake of publicly funded childhood vaccines and in cognitive determinants (beliefs, attitudes) of parental decisions about vaccinating their children. Using the PRISMA statement to guide this review, we searched three electronic databases from January 2000 through April 2016...
September 15, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28913330/resurgence-of-diphtheria-in-north-kerala-india-2016-laboratory-supported-case-based-surveillance-outcomes
#15
Lucky Sangal, Sudhir Joshi, Shalini Anandan, Veeraraghavan Balaji, Jaichand Johnson, Asish Satapathy, Pradeep Haldar, Ramesh Rayru, Srinath Ramamurthy, Asha Raghavan, Pankaj Bhatnagar
INTRODUCTION: As part of national program, laboratory supported vaccine preventable diseases surveillance was initiated in Kerala in 2015. Mechanisms have been strengthened for case investigation, reporting, and data management. Specimens collected and sent to state and reference laboratories for confirmation and molecular surveillance. The major objective of this study is to understand the epidemiological information generated through surveillance system and its utilization for action...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28912394/-hpv-vaccination-program-the-history-and-recent-progress
#16
Hiroyuki Yoshikawa
Four years have passed since HPV vaccination "crisis" occurred in June 2013. In Japan,a publicly funded HPV vaccination program for adolescent females aged 12-16 years began in December 2010. However,the Japanese government withdrew its recommendation for HPV vaccination in June, 2013 because news reports on potential adverse effects of HPV vaccines without any medical evidence appeared repeatedly. The vaccination coverage among adolescent females decreased quickly from around 70%in females born between 1994 and 1999 to only 1%in females born since 2001 over the country...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28911902/the-impact-of-10-valent-and-13-valent-pneumococcal-conjugate-vaccines-on-hospitalization-for-pneumonia-in-children-a-systematic-review-and-meta-analysis
#17
REVIEW
Cristiano Alicino, Chiara Paganino, Andrea Orsi, Matteo Astengo, Cecilia Trucchi, Giancarlo Icardi, Filippo Ansaldi
BACKGROUND: This systematic review and meta-analysis aimed at summarizing available data on the impact of PCV10 and PCV13 in reducing the incidence of CAP hospitalizations in children aged <5years. METHODS: A systematic search of the literature was conducted. We included time-series analyses and before-after studies, reporting the incidence of hospitalization for pneumonia in the periods before and after the introduction of PCV10 or PCV13 into the immunization program...
September 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28911750/effect-of-counselling-on-health-care-seeking-behaviours-and-rabies-vaccination-adherence-after-dog-bites-in-haiti-2014-15-a-retrospective-follow-up-survey
#18
Melissa Dominique Etheart, Maxwell Kligerman, Pierre Dilius Augustin, Jesse D Blanton, Benjamin Monroe, Ludder Fleurinord, Max Millien, Kelly Crowdis, Natael Fenelon, Ryan MacLaren Wallace
BACKGROUND: Haiti has an integrated bite case management (IBCM) programme to counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the animals. We assessed the usefulness of the IBCM programme to promote best practices for rabies prophylaxis after exposure in a low-income rabies-endemic setting. METHODS: We did a retrospective follow-up survey of randomly selected bite victims who were counselled by Haiti's IBCM programme between May 15, 2014, and Sept 15, 2015...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28906006/prevalence-of-anal-oral-penile-and-urethral-human-papillomavirus-in-hiv-infected-and-hiv-uninfected-men-who-have-sex-with-men
#19
Claudio Ucciferri, Manuela Tamburro, Katia Falasca, Michela Lucia Sammarco, Giancarlo Ripabelli, Jacopo Vecchiet
Aims of the study were to evaluate Human Papillomavirus (HPV) and type-specific prevalence in four anatomical sites in HIV infected men who have sex with men (MSM) compared with HIV uninfected MSM. Participants were recruited among the attendees of Infectious Diseases Clinics in Central Italy. A trained medical practitioner collected by interview sociodemographic data and information on medical history, sexual behavior and drug use. Swabs from anal canal, oral cavity, urethral mucosa and coronal sulcus were tested for HPV DNA and genotyping...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28904193/mutations-in-the-fusion-protein-of-measles-virus-that-confer-resistance-to-the-membrane-fusion-inhibitors-carbobenzoxy-d-phe-l-phe-gly-and-as-48
#20
Michael N Ha, Sébastien Delpeut, Ryan S Noyce, Gary Sisson, Karen M Black, Liang-Tzung Lin, Darius Bilimoria, Richard K Plemper, Gilbert G Privé, Christopher D Richardson
The inhibitors Z-d-Phe-l-Phe Gly (fusion inhibitor peptide, FIP) and AS-48 have similar efficacy in blocking membrane fusion and syncytia formation mediated by measles virus. Other homologues such as Z-d-Phe are less effective, but may act through the same mechanism. In an attempt to map the site of action of these inhibitors, we generated mutant viruses which were resistant to the inhibitory effects of Z-d-Phe-l-Phe Gly. These 10 mutations were localized to the heptad repeat region (HRB) of the fusion protein and no changes were observed in the viral hemagglutinin, which is the receptor attachment protein...
September 13, 2017: Journal of Virology
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