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https://www.readbyqxmd.com/read/29165783/after-action-review-of-the-2009-10-h1n1-influenza-outbreak-response-ohio-s-public-health-system-s-performance
#1
William A Mase, Beth Bickford, Casey L Thomas, Shamika D Jones, Michael Bisesi
OBJECTIVE: In early 2009, H1N1 influenza was identified within the human population. Centers for Disease Control and Prevention (CDC) officials responded with focused assessment, policy development, and assurances. The response was mobilized through efforts including procurement of adequate vaccine supply, local area span of control, materials acquisition, and facilities and resource identification. METHODS: Qualitative evaluation of the assurance functions specific to the system's ability to assure safe and healthy conditions are reported...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29164952/review-of-vaccine-effectiveness-assumptions-used-in-economic-evaluations-of-infant-pneumococcal-conjugate-vaccine
#2
Matthew Wasserman, Heather Sings, Dylan Jones, Sarah Pugh, Margaret Moffatt, Raymond Farkouh
Pneumococcal conjugate vaccines (PCVs) have provided a significant clinical and economic impact globally. The majority of countries which have implemented an infant PCV program have observed a substantial reduction in the burden of invasive pneumococcal disease (IPD), pneumococcal pneumonia, and acute otitis media (AOM) due to vaccine serotypes. After 17 years of use, many countries have evaluated and re-evaluated the value of their vaccine program using cost-effectiveness analyses; however, many of these analyses do not reflect the current body of evidence...
November 22, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29163652/phylogenic-analysis-of-serotype-asia1-foot-and-mouth-disease-virus-from-sulaimani-iraq-using-vp1-protein-heterogeneity-with-vaccine-strain-as1-shamir-89
#3
M O Baba Sheikh, P M A Rashid, A S Marouf, Z H Raheem, S C Janga
Foot-and-mouth disease virus (FMDV) serotypes O, A and Asia1 are responsible for a significant number of disease outbreaks in Iraq. The current study can be considered as the first molecular characterization of serotype Asia1 in Iraq. The present investigation reports the detection of serotype FMDV Asia1 from local farms in Sulaimani districts in 2012 and 2014 outbreaks. Phylogenetic analysis of the complete VP1 gene has shown that FMDV Asia1 field isolates were under genetic novel variant Sindh-08 (group VII) including PAK/iso/11 and TUR/13 strains...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/29163518/mixed-signals-co-stimulation-in-invariant-natural-killer-t-cell-mediated-cancer-immunotherapy
#4
REVIEW
Susannah C Shissler, Michael S Lee, Tonya J Webb
Invariant natural killer T (iNKT) cells are an integral component of the immune system and play an important role in antitumor immunity. Upon activation, iNKT cells can directly kill malignant cells as well as rapidly produce cytokines that stimulate other immune cells, making them a front line defense against tumorigenesis. Unfortunately, iNKT cell number and activity are reduced in multiple cancer types. This anergy is often associated with upregulation of co-inhibitory markers such as programmed death-1...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163465/b-cell-activating-factor-and-the-b-cell-compartment-in-hiv-siv-infection
#5
REVIEW
Gwenoline Borhis, Maria Trovato, Nada Chaoul, Hany M Ibrahim, Yolande Richard
With the goal to design effective HIV vaccines, intensive studies focused on broadly neutralizing antibodies, which arise in a fraction of HIV-infected people. Apart from identifying new vulnerability sites in the viral envelope proteins, these studies have shown that a fraction of these antibodies are produced by self/poly-reactive B-cells. These findings prompted us to revisit the B-cell differentiation and selection process during HIV/SIV infection and to consider B-cells as active players possibly shaping the helper T-cell program within germinal centers (GCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162636/quantitative-proteomic-profiling-reveals-novel-plasmodium-falciparum-surface-antigens-and-possible-vaccine-candidates
#6
Sandra K Nilsson Bark, Rushdy Ahmad, Kathleen Dantzler, Amanda K Lukens, Mariana De Niz, Matthew J Szucs, Xiaojing Jin, Joanne Cotton, Dietmar Hoffmann, Eva Bric-Furlong, Ray Oomen, Mark Parrington, Dan Milner, Daniel E Neafsey, Steven A Carr, Dyann F Wirth, Matthias Marti
Despite recent efforts towards control and elimination, malaria remains a major public health problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line combination drugs, is on the rise, and the only approved vaccine shows limited efficacy. Combinations of novel and tailored drug and vaccine interventions are required to maintain the momentum of the current malaria elimination program. Current evidence suggests that strain-transcendent protection against malaria infection can be achieved using whole organism vaccination or with a polyvalent vaccine covering multiple antigens or epitopes...
November 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29162319/impact-of-rotavirus-vaccine-on-acute-gastroenteritis-in-children-under-5-years-in-senegal-experience-of-sentinel-site-of-the-albert-royer-children-s-hospital-in-dakar
#7
Amadou Diop, Aliou Thiongane, Jason M Mwenda, Negar Aliabadi, Mouhamadou A Sonko, Aliou Diallo, Babacar Ndoye, Papa M Faye, Idrissa D Ba, Umesh D Parashar, Jacqueline E Tate, Ousmane Ndiaye, Moussa F Cissé, Mamadou Ba
BACKGROUND: Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality among children <5 years of age in developing countries, with rotavirus being the most common infectious etiology. In November 2014, monovalent rotavirus vaccine was introduced in Senegal. We determined the impact of rotavirus vaccine on hospitalizations for all-cause and rotavirus related AGE in children <60 months of age. METHODS: We examined two data sources from the national referral hospital...
November 18, 2017: Vaccine
https://www.readbyqxmd.com/read/29161487/virological-surveillance-of-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-as-support-for-decision-making-for-dengue-control-in-medell%C3%A3-n
#8
Juliana Pérez-Pérez, William H Sanabria, Carolina Restrepo, Raúl Rojo, Enrique Henao, Omar Triana, Ana María Mejía, Sandra M Castaño, Guillermo L Rúa-Uribe
INTRODUCTION: Dengue represents an important public health problem in Colombia. No treatment is available and the vaccine has not been approved in all countries, hence, actions should be strengthened to mitigate its impact through the control of Aedes aegypti, the vector mosquito. In Colombia, surveillance is done using entomological indexes and case notification, which is usually informed late, leading to untimely interventions. Viral detection in urban mosquitoes using molecular techniques provides more accurate entomological information for decision-making...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29160642/neonatal-bacterial-meningitis-a-systematic-review-of-european-available-data
#9
Antonio DI Mauro, Francesca Cortese, Nicola Laforgia, Beatrice Pantaleo, Rachele Giuliani, Donato Bonifazi, Marco M Ciccone, Paola Giordano
BACKGROUND: Despite advances in neonatal intensive care and the improvements in surveillance, prevention and vaccination programs, neonatal meningitis still represents an important cause of morbidity and mortality in infants, with the highest mortality in the newborn population. AIM: To summarize current knowledge about this topic with particular attention to management of neonatal meningitis in order to provide a useful tool for clinicians. METHODS: We reviewed the existent literature from five European Countries (France, German, Italy, Spain and United Kingdom) on the effectiveness of treatments for bacterial meningitis in newborns taking into consideration the antibiotic resistance phenomenon...
November 21, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29159785/improving-the-hospital-quality-of-care-during-winter-periods-by-optimizing-budget-allocation-between-rotavirus-vaccination-and-bed-expansion
#10
Thibaut Dort, Nadia Schecroun, Baudouin Standaert
BACKGROUND: During each winter the hospital quality of care (QoC) in pediatric wards decreases due to a surge in pediatric infectious diseases leading to overcrowded units. Bed occupancy rates often surpass the good hospital bed management threshold of 85%, which can result in poor conditions in the workplace. This study explores how QoC-scores could be improved by investing in additional beds and/or better vaccination programs against vaccine-preventable infectious diseases. METHODS: The Cobb-Douglas model was selected to define the improvement in QoC (%) as a function of two strategies (rotavirus vaccination coverage [%] and addition of extra hospital beds [% of existing beds]), allowing improvement-isocurves to be produced...
November 20, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#11
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29157959/the-risk-of-lower-respiratory-tract-infection-following-influenza-virus-infection-a-systematic-and-narrative-review
#12
Ryan E Malosh, Emily T Martin, Justin R Ortiz, Arnold S Monto
BACKGROUND: Lower respiratory tract infections (LRTI) are a major cause of morbidity and mortality worldwide, particularly in young children and older adults. Influenza is known to cause severe disease but the risk of developing LRTI following influenza virus infection in various populations has not been systematically reviewed. Such data are important for estimating the impact specific influenza vaccine programs would have on LRTI outcomes in a community. We sought to review the published literature to determine the risk of developing LRTI following an influenza virus infection in individuals of any age...
November 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29157448/ab-initio-conformational-epitope-structure-prediction-using-genetic-algorithm-and-svm-for-vaccine-design
#13
Basem Ameen Moghram, Emad Nabil, Amr Badr
BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine design. Epitopes or antigenic peptides are a set of amino acids that bind with the Major Histocompatibility Complex (MHC) molecules. The aim of this process is presented by Antigen Presenting Cells to be inspected by T-cells. MHC-molecule-binding epitopes are responsible for triggering the immune response to antigens. The epitope's three-dimensional (3D) molecular structure (i...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157329/the-need-for-rotavirus-vaccine-introduction-in-the-national-immunization-program-of-more-than-100-countries-around-the-world
#14
Manoochehr Karami, Zeinab Berangi
No abstract text is available yet for this article.
November 21, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29155677/expanding-pertussis-epidemiology-in-6-latin-america-countries-through-the-latin-american-pertussis-project
#15
Veronica A Pinell-McNamara, Anna M Acosta, Maria Cristina Pedreira, Ana F Carvalho, Lucia Pawloski, Maria Lucia Tondella, Elizabeth Briere
The Latin American Pertussis Project (LAPP), established in 2009, is a collaboration between the Centers for Disease Control and Prevention, Pan American Health Organization, Sabin Vaccine Institute, and the ministries of health of 6 countries in Latin America. The project goal is to expand understanding of pertussis epidemiology in Latin America to inform strategies for control and prevention. Here we describe LAPP structure and activities. After an initial surveillance evaluation, LAPP activities are tailored to individual country needs...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155675/enhancing-workforce-capacity-to-improve-vaccination-data-quality-uganda
#16
Kirsten Ward, Kevin Mugenyi, Amalia Benke, Henry Luzze, Carol Kyozira, Ampeire Immaculate, Patricia Tanifum, Annet Kisakye, Peter Bloland, Adam MacNeil
In Uganda, vaccine dose administration data are often not available or are of insufficient quality to optimally plan, monitor, and evaluate program performance. A collaboration of partners aimed to address these key issues by deploying data improvement teams (DITs) to improve data collection, management, analysis, and use in district health offices and health facilities. During November 2014-September 2016, DITs visited all districts and 89% of health facilities in Uganda. DITs identified gaps in awareness and processes, assessed accuracy of data, and provided on-the-job training to strengthen systems and improve healthcare workers' knowledge and skills in data quality...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155666/cdc-activities-for-improving-implementation-of-human-papillomavirus-vaccination-cervical-cancer-screening-and-surveillance-worldwide
#17
Virginia Senkomago, Denise Duran, Anagha Loharikar, Terri B Hyde, Lauri E Markowitz, Elizabeth R Unger, Mona Saraiya
Cervical cancer incidence and mortality rates are high, particularly in developing countries. Most cervical cancers can be prevented by human papillomavirus (HPV) vaccination, screening, and timely treatment. The US Centers for Disease Control and Prevention (CDC) provides global technical assistance for implementation and evaluation of HPV vaccination pilot projects and programs and laboratory-related HPV activities to assess HPV vaccines. CDC collaborates with global partners to develop global cervical cancer screening recommendations and manuals, implement screening, create standardized evaluation tools, and provide expertise to monitor outcomes...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155651/enhancing-surveillance-and-diagnostics-in-anthrax-endemic-countries
#18
Antonio R Vieira, Johanna S Salzer, Rita M Traxler, Katherine A Hendricks, Melissa E Kadzik, Chung K Marston, Cari B Kolton, Robyn A Stoddard, Alex R Hoffmaster, William A Bower, Henry T Walke
Naturally occurring anthrax disproportionately affects the health and economic welfare of poor, rural communities in anthrax-endemic countries. However, many of these countries have limited anthrax prevention and control programs. Effective prevention of anthrax outbreaks among humans is accomplished through routine livestock vaccination programs and prompt response to animal outbreaks. The Centers for Disease Control and Prevention uses a 2-phase framework when providing technical assistance to partners in anthrax-endemic countries...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29151863/a-phylogenomic-analysis-of-marek-s-disease-virus-reveals-independent-paths-to-virulence-in-eurasia-and-north-america
#19
Jakob Trimpert, Nicole Groenke, Maria Jenckel, Shulin He, Dusan Kunec, Moriah L Szpara, Stephen J Spatz, Nikolaus Osterrieder, Dino P McMahon
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus (MDV), a herpesvirus commonly afflicting chickens and rarely other avian species. The history of MDV in the 20th century represents an important case study in the evolution of virulence. The severity of MDV infection in chickens has been rising steadily since the adoption of intensive farming techniques and vaccination programs in the 1950s and 1970s, respectively...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29150937/cgmp-production-and-analysis-of-bg505-sosip-664-an-extensively-glycosylated-trimeric-hiv-1-envelope-glycoprotein-vaccine-candidate
#20
Antu K Dey, Albert Cupo, Gabriel Ozorowski, Vaneet K Sharma, Anna-Janina Behrens, Eden P Go, Thomas J Ketas, Anila Yasmeen, Per J Klasse, Eddy Sayeed, Heather Desaire, Max Crispin, Ian A Wilson, Rogier W Sanders, Thomas Hassell, Andrew Ward, John P Moore
We describe the properties of BG505 SOSIP.664 HIV-1 envelope glycoprotein trimers produced under current Good Manufacturing Practice (cGMP) conditions. These proteins are the first of a new generation of native-like trimers that are the basis for many structure-guided immunogen development programs aimed at devising how to induce broadly neutralizing antibodies (bNAbs) to HIV-1 by vaccination. The successful translation of this prototype demonstrates the feasibility of producing similar immunogens on an appropriate scale and of an acceptable quality for Phase I experimental medicine clinical trials...
November 18, 2017: Biotechnology and Bioengineering
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