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https://www.readbyqxmd.com/read/28214188/prevalence-of-human-papillomavirus-infection-among-71-435-women-in-jiangxi-province-china
#1
Tian-Yu Zhong, Ji-Chun Zhou, Rong Hu, Xiao-Na Fan, Xiao-Ying Xie, Zhao-Xia Liu, Min Lin, Yi-Guo Chen, Xiao-Mei Hu, Wei-Hua Wang, Long Li, Hua-Ping Xiao
Cervical cancer is the third most common cancer in women worldwide. Human papillomavirus (HPV) has been identified as an etiological factor for cervical cancer. Data on the prevalence and subtype distribution of HPV infection in Jiangxi Province are incomplete. In this study, we investigated HPV subtype distribution and prevalence in Jiangxi Province between August 1, 2010, and December 31, 2015. A total of 71,435 individuals ranging in age from 16 to 77 years were recruited. Cervicovaginal swabs were collected from each participant, and HPV screening was performed...
February 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28213434/malaria-during-pregnancy
#2
Michal Fried, Patrick E Duffy
One hundred and twenty-five million women in malaria-endemic areas become pregnant each year (see Dellicour et al. PLoS Med7: e1000221 [2010]) and require protection from infection to avoid disease and death for themselves and their offspring. Chloroquine prophylaxis was once a safe approach to prevention but has been abandoned because of drug-resistant parasites, and intermittent presumptive treatment with sulfadoxine-pyrimethamine, which is currently used to protect pregnant women throughout Africa, is rapidly losing its benefits for the same reason...
February 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28209436/is-colombia-reaching-the-goals-on-infant-immunization-coverage-a-quantitative-survey-from-80-municipalities
#3
Javier Narváez, May Bibiana Osorio, Carlos Castañeda-Orjuela, Nelson Alvis Zakzuk, Natalia Cediel, Luz Ángela Chocontá-Piraquive, Fernando de La Hoz-Restrepo
OBJECTIVES: This study aimed to evaluate the coverage of the Colombian Expanded Program on Immunization among children less than 6years old, to evaluate the timeliness of immunization, to assess the coverage of newly introduced vaccines, and to identify factors associated with lack of immunization. METHODS: We conducted a cross-sectional survey in 80 municipalities of Colombia, using a two-stage cluster random sampling. We attempted to contact all children less than 6years old living in the sampled blocks, and asked their caregivers to provide immunization record cards...
February 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28208616/immunoinformatics-features-linked-to-leishmania-vaccine-development-data-integration-of-experimental-and-in-silico-studies
#4
Rory C F Brito, Frederico G Guimarães, João P L Velloso, Rodrigo Corrêa-Oliveira, Jeronimo C Ruiz, Alexandre B Reis, Daniela M Resende
Leishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. There is no human vaccine available and it is considered by many studies as apotential effective tool for disease control. To discover novel antigens, computational programs have been used in reverse vaccinology strategies. In this work, we developed a validation antigen approach that integrates prediction of B and T cell epitopes, analysis of Protein-Protein Interaction (PPI) networks and metabolic pathways. We selected twenty candidate proteins from Leishmania tested in murine model, with experimental outcome published in the literature...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207888/effect-of-the-different-13-valent-pneumococcal-conjugate-vaccination-uptakes-on-the-invasive-pneumococcal-disease-in-children-analysis-of-a-hospital-based-and-population-based-surveillance-study-in-madrid-spain-2007-2015
#5
Juan Picazo, Jesús Ruiz-Contreras, Juan Casado-Flores, Sagrario Negreira, Fernando Baquero, Teresa Hernández-Sampelayo, Enrique Otheo, Cristina Méndez
In the Community of Madrid, the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent (PCV7) in the fully government-funded Regional Immunization Program (RIP) in May, 2010, but was later excluded in May, 2012, and included again in January, 2015. These unique changes allowed us to assess the impact of the different pneumococcal vaccination policies on PCV13 uptake in infants and on the incidence rate (IR) of invasive pneumococcal disease (IPD) in children <15 years old. In this prospective, active, surveillance study, we estimated PCV13 uptakes, IR and incidence rate ratios (IRR) for total IPD and for IPD caused by PCV13- and non-PCV13 serotypes in children <15 years, stratified by age, in four periods with different vaccination policies: fully government-funded PCV7 vaccination, fully government-funded PCV13, mixed public/private funding and only private funding...
2017: PloS One
https://www.readbyqxmd.com/read/28207677/predictors-of-human-papillomavirus-vaccine-initiation-and-completion-among-latino-mothers-of-11-to-17-year-old-daughters-living-along-the-texas-mexico-border
#6
Daisy Y Morales-Campos, Deborah Parra-Medina
Few Texas Latino girls initiate and complete the human papillomavirus (HPV) vaccine series, but few studies have examined predictors of initiation and completion in this group. Mothers are crucial to vaccine uptake. Using self-reported data from mothers of unvaccinated girls (n = 317), we examined the association between predictors (HPV and HPV vaccine knowledge, vaccine self-efficacy) and outcomes (initiation and completion). Despite an increase in HPV and HPV vaccine knowledge from baseline to follow-up (n = 195), we found no association between the predictors and the outcomes...
April 2017: Family & Community Health
https://www.readbyqxmd.com/read/28207078/emerging-infectious-diseases-animals-and-future-epidemics
#7
Herbert L DuPont
Emerging and reemerging infections have become prevalent in the United States since the 1970s, causing illness, death, and fear among the public. The published literature was reviewed to offer a perspective on risk factors for disease acquisition and to allow a prediction of the next microbial assault after Ebola and Zika. Four well-integrated factors likely will contribute simultaneously: animals colonized or infected by pathogens capable of human transmission, microbes recurrently changing their virulence, a growing number of susceptible people, and climatic and environmental factors encouraging disease transmission...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28199772/a-retrospective-study-of-hepatitis-b-mother-to-child-transmission-prevention-and-post-vaccination-serological-test-results-of-infants-at-risk-of-perinatal-transmission-in-two-counties-of-middle-china
#8
Guo Yonghao, Dong Pumei, Yang Jianhui, Xu Jin, Zhang Yanyang, Wang Zhe
Approximately 240 million people have chronic hepatitis B worldwide, with mother-to-child-transmission (MTCT) accounting for most cases. Therefore, Henan Province, China launched a public health program to prevent MTCT. To determine the efficacy of this health program, a survey was carried out in Huixian and Xinan counties, which are located in northern and western Henan. All infants born in these two counties between January 1, 2013 and March 31, 2014 to a mother positive for hepatitis B surface antigen (HBsAg), were surveyed; in total, there were 438 mother-infant pairs...
February 15, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28199305/sterile-protection-against-human-malaria-by-chemoattenuated-pfspz-vaccine
#9
Benjamin Mordmüller, Güzin Surat, Heimo Lagler, Sumana Chakravarty, Andrew S Ishizuka, Albert Lalremruata, Markus Gmeiner, Joseph J Campo, Meral Esen, Adam J Ruben, Jana Held, Carlos Lamsfus Calle, Juliana B Mengue, Tamirat Gebru, Javier Ibáñez, Mihály Sulyok, Eric R James, Peter F Billingsley, K C Natasha, Anita Manoj, Tooba Murshedkar, Anusha Gunasekera, Abraham G Eappen, Tao Li, Richard E Stafford, Minglin Li, Phil L Felgner, Robert A Seder, Thomas L Richie, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner
A highly protective malaria vaccine would greatly facilitate the prevention and elimination of malaria and containment of drug-resistant parasites. A high level (more than 90%) of protection against malaria in humans has previously been achieved only by immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (PfSPZ) inoculated by mosquitoes; by intravenous injection of aseptic, purified, radiation-attenuated, cryopreserved PfSPZ ('PfSPZ Vaccine'); or by infectious PfSPZ inoculated by mosquitoes to volunteers taking chloroquine or mefloquine (chemoprophylaxis with sporozoites)...
February 15, 2017: Nature
https://www.readbyqxmd.com/read/28197373/systemic-activation-of-antigen-presenting-cells-via-rna-loaded-nanoparticles
#10
Elias J Sayour, Gabriel De Leon, Christina Pham, Adam Grippin, Hanna Kemeny, Joshua Chua, Jianping Huang, John H Sampson, Luis Sanchez-Perez, Catherine Flores, Duane A Mitchell
While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. RNA-NPs bypass MHC restriction, are amenable to central distribution, and can provide near immediate immune induction...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28194462/designing-an-efficient-multi-epitope-oral-vaccine-against-helicobacter-pylori-using-immunoinformatics-and-structural-vaccinology-approaches
#11
Navid Nezafat, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Reza Rahbar, Younes Ghasemi
Helicobacter pylori is the cunning bacterium that can live in the stomachs of many people without any symptoms, but gradually can lead to gastric cancer. Due to various obstacles, which are related to anti-H. pylori antibiotic therapy, recently developing an anti-H. pylori vaccine has attracted more attention. In this study, different immunoinformatics and computational vaccinology approaches were employed to design an efficient multi-epitope oral vaccine against H. pylori. Our multi-epitope vaccine is composed of heat labile enterotoxin IIc B (LT-IIc) that is used as a mucosal adjuvant to enhance vaccine immunogenicity for oral immunization, cartilage oligomeric matrix protein (COMP) to increase vaccine stability in acidic pH of gut, one experimentally protective antigen, OipA, and two hypothetical protective antigens, HP0487 and HP0906, and "CTGKSC" peptide motif that target epithelial microfold cells (M cells) to enhance vaccine uptake from the gut barrier...
February 14, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28194210/recommended-immunization-schedule-for-children-and-adolescents-immunization-guideline-8th-edition-released-by-the-korean-pediatric-society-in-2015
#12
REVIEW
Jong-Hyun Kim, Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Jina Lee, Soo-Young Lee, Hyunju Lee, Ki Hwan Kim, Kyung-Hyo Kim
This report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) Immunization Guidelines released by the Committee on Infectious Diseases of the Korean Pediatric Society (KPS). Notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of Haemophilus influenzae type b vaccine, pneumococcal conjugate vaccine, and hepatitis A vaccine into the National Immunization Program since 2012; addition of general recommendations for 2 new Japanese encephalitis (JE) vaccines and their interchangeability with existing JE vaccines; addition of general recommendations for quadrivalent meningococcal conjugate vaccines and scope of the recommended targets for vaccination; and emphasizing catch-up immunization of Tdap vaccine...
December 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28193663/results-from-a-patient-based-health-education-intervention-in-reducing-antibiotic-use-for-acute-upper-respiratory-tract-infections-in-the-private-sector-primary-care-setting-in-singapore
#13
Magdalene Hui Min Lee, Darius Shaw Teng Pan, Joyce Huixin Huang, Mark I-Cheng Chen, Joash Wen Chen Chong, Ee Hui Goh, Lili Jiang, Yee Sin Leo, Tau Hong Lee, Chia Siong Wong, Victor Weng Keong Loh, Fong Seng Lim, Adrian Zhongxian Poh, Tat Yean Tham, Wei Mon Wong, Yue Yu
We investigated the efficacy of patient-targeted education in reducing antibiotic prescriptions for upper respiratory tract infections (URTIs) amongst adults in the private primary care setting in Singapore. Our randomized controlled trial enrolled patients aged 21 years and above presenting at GP (general practitioner) clinics with URTI symptoms for 7 days or less. Intervention arm patients were verbally educated via pamphlets about the aetiology of URTIs, role of antibiotics in treating URTIs, and consequences of inappropriate antibiotic use...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192438/advances-in-neglected-tropical-disease-vaccines-developing-relative-potency-and-functional-assays-for-the-na-gst-1-alhydrogel-hookworm-vaccine
#14
Jill B Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J Hotez, David Diemert, Jeffrey M Bethony
A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD vaccine product development, more specifically, vaccine stability testing programs. A key measure of vaccine stability testing is "relative potency" or the immunogenicity of the vaccine during storage. As with most NTD vaccines, the Na-GST-1/Alhydrogel Hookworm Vaccine was not developed by attenuation or inactivation of the pathogen (Necator americanus), so conventional methods for measuring relative potency are not relevant for this investigational product...
February 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28190744/use-of-m-health-in-polio-eradication-and-other-immunization-activities-in-developing-countries
#15
REVIEW
Sara S Kim, Manish Patel, Alan Hinman
INTRODUCTION: Reaching the children that are chronically missed by routine immunization services has been a key pillar of success in achieving progress toward polio eradication. The rapid advancement and accessibility of mobile technology ("mHealth") in low and lower middle income countries provides an important opportunity to apply novel, innovative approaches to provide vaccine services. We sought to document the use and effectiveness of mHealth in immunization programs in low and lower middle income countries...
February 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28190742/pcv13-serotype-decrease-in-italian-adolescents-and-adults-in-the-post-pcv13-era-herd-protection-from-children-or-secular-trend
#16
Francesco Nieddu, Maria Moriondo, Elisa De Vitis, Silvia Ricci, Giuseppe Indolfi, Massimo Resti, Caterina Vocale, Maria Paola Landini, Assunta Sartor, Chiara Azzari
BACKGROUND AND AIM OF THE WORK: In 2010 PCV13 replaced PCV7 in the pediatric vaccination schedule for Italian children. While a strong herd effect was demonstrated for PCV7, a possible herd effect due to PCV13 is still under debate. Our aim was to evaluate differences in the distribution of pneumococcal serotypes between the pre and post-PCV13 eras in unvaccinated Italian adolescents and adults with laboratory-confirmed pneumococcal infection from 3 Italian Regions with a high rate of PCV13 vaccination of children...
February 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28182657/modeling-the-potential-for-vaccination-to-diminish-the-burden-of-invasive-non-typhoidal-salmonella-disease-in-young-children-in-mali-west-africa
#17
Kristin Bornstein, Laura Hungerford, David Hartley, John D Sorkin, Milagritos D Tapia, Samba O Sow, Uma Onwuchekwa, Raphael Simon, Sharon M Tennant, Myron M Levine
BACKGROUND: In sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where infant vaccination against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in Bamako, Mali, their burden has decreased markedly. In parallel, NTS has become the predominant invasive bacterial pathogen in children aged <5 years...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28182307/chronologic-changes-of-serum-hepatitis-b-virus-dna-genotypes-surface-antigen-mutants-and-reverse-transcriptase-mutants-during-25-year-nationwide-immunization-in-taiwan
#18
Hong-Yuan Hsu, Mei-Hwei Chang, Yen-Hsuan Ni, Cheng-Lun Chiang, Jia-Feng Wu, Huey-Ling Chen, Pei-Jer Chen, Ding-Shinn Chen
We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25-year of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25-years-old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5...
February 9, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28181989/-influence-of-age-in-the-prevalence-of-high-risk-human-papiloma-virus-in-women-with-pre-neoplasic-cervical-lesions-in-navarra-spain
#19
María Rosario Mercado Gutiérrez, Carolina Arean Cuns, María Luisa Gómez Dorronsoro, Irene Paniello Alastruey, Fermin Mallor Giménez, Maria Dolores Lozano Escario, Mercedes Santamaría Martínez
OBJECTIVE: Cervical carcinoma (CC) is the second cause of death among women aged 15 and 44 in Spain. CC is linked to hig-risk human papillomavirus (HR-HPV) infection and its prevalence varies according age and geographical region. The awereness of the latter is essential for public health prevention efforts. The aim was to study the age related in HR-HPV genotypes in cytologies with squamous intraepithelial lesion (SIL). METHODS: From a total of 67,935 ginecologic cytologies over a four-year period, we selected cytologic specimens with SIL...
9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28179020/hepatitis-b-virus-infection-in-undocumented-immigrants-and-refugees-in-southern-italy-demographic-virological-and-clinical-features
#20
Nicola Coppola, Loredana Alessio, Luciano Gualdieri, Mariantonietta Pisaturo, Caterina Sagnelli, Carmine Minichini, Giovanni Di Caprio, Mario Starace, Lorenzo Onorato, Giuseppe Signoriello, Margherita Macera, Italo Francesco Angelillo, Giuseppe Pasquale, Evangelista Sagnelli
BACKGROUND: The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy. METHODS: A screening for HBV infection was offered to 1,331 immigrants, of whom 1,212 (91%) (831 undocumented immigrants and 381 refugees) accepted and were screened for hepatitis B surface antigen (HBsAg) and anti-hepatitis B core antibody (HBc)...
February 9, 2017: Infectious Diseases of Poverty
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