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Krill oil

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https://www.readbyqxmd.com/read/29222893/postprandial-long-chain-n-3-polyunsaturated-fatty-acid-response-to-krill-oil-and-fish-oil-consumption-in-healthy-women-a-randomised-controlled-single-dose-crossover-study
#1
Hyunsin H Sung, Andrew J Sinclair, Paul A Lewandowski, Xiao Q Su
BACKGROUND AND OBJECTIVES: Krill oil (KO) and fish oil (FO) are good sources of health-benefiting long chain n- 3 polyunsaturated fatty acids (LC n-3 PUFA), EPA and DHA. There are conflicting outcomes on the bioavailability of LC n-3 PUFA from KO compared with FO. This study investigated the postprandial incorporation of LC n- 3 PUFA into plasma lipids following consumption of 5 capsules of KO or FO in comparison with olive oil (OO) control in healthy women. METHODS AND STUDY DESIGN: 10 women (aged 18-45 years) consumed a high-fat (15 g) breakfast, supplemented with 5 g of KO, FO, or OO in a random order with a minimum seven-day washout period between the supplementations...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29206479/microencapsulation-of-esterified-krill-oil-using-complex-coacervation
#2
Selim Kermasha, Sarya Aziz, Jagpreet Gill, Ronald Neufeld
The microencapsulation of the esterified krill oil (EKO), obtained from the transesterification of krill oil (KO) with 3,4-dihydroxyphenylacetic acid (DHPA), via complex coacervation, was investigated. The experimental findings showed that the DHPA and phenolic lipids (PLs) in the EKO affected the stability of the gelatin (GE)-EKO emulsion. To improve its stability, the effects of varying the pH of GE and the use of two emulsification devices, including the homogenizer and ultrasonic liquid processor were investigated, where the ultrasonic liquid processor was found to be a relatively more appropriate emulsification device...
December 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29182579/antarctic-krill-oil-diet-protects-against-lipopolysaccharide-induced-oxidative-stress-neuroinflammation-and-cognitive-impairment
#3
Ji Yeon Choi, Jun Sung Jang, Dong Ju Son, Hyung-Sik Im, Ji Yeong Kim, Joung Eun Park, Won Rak Choi, Sang-Bae Han, Jin Tae Hong
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer's disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29157255/effects-of-antarctic-krill-oil-on-lipid-and-glucose-metabolism-in-c57bl-6j-mice-fed-with-high-fat-diet
#4
Dewei Sun, Liang Zhang, Hongjian Chen, Rong Feng, Peirang Cao, Yuanfa Liu
BACKGROUND: Obesity and other metabolic diseases have become epidemic which greatly affect human health. Diets with healthy nutrition are efficient means to prevent this epidemic occurrence. Novel food resources and process technology were needed for these purpose. In this study, Antarctic krill oil (KO) extracted from a dry krill by a procedure of hot pump dehydration in combined with freezing-drying was used to investigate health effect in animals including the growth, lipid and glucose metabolism...
November 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29120783/micro-emulsification-encapsulation-of-krill-oil-by-complex-coacervation-with-krill-protein-isolated-using-isoelectric-solubilization-precipitation
#5
Liu Shi, Sarah K Beamer, Hong Yang, Jacek Jaczynski
This study determined feasibility of krill protein isolated with isoelectric solubilization/precipitation (ISP) as wall material to microencapsulate krill oil by freeze-drying. Effects of krill oil/krill protein ratio on properties of microcapsules were investigated. With increased ratio, crude protein of microcapsules decreased, while total lipid increased. Although microcapsule oil loading capacity increased, loading and encapsulation efficiencies decreased. Thin layer chromatography (TLC) confirmed abundance of phospholipids, which are amphiphilic; and thus, resulted in stable emulsion (emulsion stability index)...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29113061/effects-of-marine-oils-digested-with-human-fluids-on-cellular-viability-and-stress-protein-expression-in-human-intestinal-caco-2-cells
#6
Cecilia Tullberg, Gerd Vegarud, Ingrid Undeland, Nathalie Scheers
In vitro digestion of marine oils has been reported to promote lipid oxidation, including the formation of reactive aldehydes (e.g., malondialdehyde (MDA) and 4-hydroxy-2-hexenal (HHE)). We aimed to investigate if human in vitro digestion of supplemental levels of oils from algae, cod liver, and krill, in addition to pure MDA and HHE, affect intestinal Caco-2 cell survival and oxidative stress. Cell viability was not significantly affected by the digests of marine oils or by pure MDA and HHE (0-90 μM). Cellular levels of HSP-70, a chaperone involved in the prevention of stress-induced protein unfolding was significantly decreased (14%, 28%, and 14% of control for algae, cod and krill oil, respectively; p ≤ 0...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29098414/microbial-diversity-and-composition-in-different-gut-locations-of-hyperlipidemic-mice-receiving-krill-oil
#7
Chenyang Lu, Tingting Sun, Yanyan Li, Dijun Zhang, Jun Zhou, Xiurong Su
Low-dose (LD, 100 mg kg(-1) day(-1)), moderate-dose (MD, 200 mg kg(-1) day(-1)), and high-dose (HD, 600 mg kg(-1) day(-1)) krill oil treatments have a stepwise, enhanced effect on alleviating hyperlipidemia, and 16S rRNA sequencing of the fecal samples demonstrates that krill oil treatment alters microbial communities. Feces may not represent all microbial communities in the gastrointestinal (GI) tract. Therefore, in this study, the stored ileal and colon samples collected from LD and HD groups were sequenced, and the location-specific modulations of microbial communities were observed after krill oil treatments...
November 2, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29016689/modulation-of-the-gut-microbiota-by-the-mixture-of-fish-oil-and-krill-oil-in-high-fat-diet-induced-obesity-mice
#8
Chenxi Cui, Yanyan Li, Hang Gao, Hongyan Zhang, Jiaojiao Han, Dijun Zhang, Ye Li, Jun Zhou, Chenyang Lu, Xiurong Su
Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28900242/dietary-docosahexaenoic-acid-dha-as-lysophosphatidylcholine-but-not-as-free-acid-enriches-brain-dha-and-improves-memory-in-adult-mice
#9
Dhavamani Sugasini, Riya Thomas, Poorna C R Yalagala, Leon M Tai, Papasani V Subbaiah
Docosahexaenoic acid (DHA) is uniquely concentrated in the brain, and is essential for its function, but must be mostly acquired from diet. Most of the current supplements of DHA, including fish oil and krill oil, do not significantly increase brain DHA, because they are hydrolyzed to free DHA and are absorbed as triacylglycerol, whereas the transporter at blood brain barrier is specific for phospholipid form of DHA. Here we show that oral administration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/kg) for 30 days increased DHA content of the brain by >2-fold...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28812326/effect-of-dietary-components-from-antarctic-krill-on-atherosclerosis-in-apoe-deficient-mice
#10
Cinzia Parolini, Bodil Bjorndal, Marco Busnelli, Stefano Manzini, Giulia S Ganzetti, Federica Dellera, Marie Ramsvik, Inge Bruheim, Rolf Kristian Berge, Giulia Chiesa
SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO)...
August 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28567037/modulation-of-the-gut-microbiota-by-krill-oil-in-mice-fed-a-high-sugar-high-fat-diet
#11
Chenyang Lu, Tingting Sun, Yanyan Li, Dijun Zhang, Jun Zhou, Xiurong Su
Multiple lines of evidence suggest that the gut microbiota plays vital roles in metabolic diseases such as hyperlipidemia. Previous studies have confirmed that krill oil can alleviate hyperlipidemia, but the underlying mechanism remains unclear. To discern whether krill oil changes the structure of the gut microbiota during the hyperlipidemia treatment, 72 mice were acclimatized with a standard chow diet for 2 weeks and then randomly allocated to receive a standard chow diet (control group, n = 12) or a high-sugar-high-fat (HSHF) diet supplemented with a low (100 μg/g·d, HSHF+LD group, n = 12), moderate (200 μg/g·d, HSHF+MD group, n = 12) or high dosage of krill oil (600 μg/g·d, HSHF+HD group, n = 12), simvastatin (HSHF+S group, n = 12) or saline (HSHF group, n = 12) continuously for 12 weeks...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28530595/comparison-of-solvents-for-extraction-of-krill-oil-from-krill-meal-lipid-yield-phospholipids-content-fatty-acids-composition-and-minor-components
#12
COMPARATIVE STUDY
Dan Xie, Jun Jin, Jiang Sun, Li Liang, Xiaosan Wang, Wei Zhang, Xingguo Wang, Qingzhe Jin
The effects of seven different extraction solvents (ethanol, isopropanol, acetone, ethyl acetate, isohexane, n-hexane, and subcritical butane) on the lipid yield and quality of the oil extracted from krill meal were investigated in this study. Phospholipids (PL), fatty acids (FA) composition and minor components including sterols, astaxanthin, vitamin A and tocopherols in the extracted krill oil were analyzed. The results indicated that ethanol and isopropanol led to comparatively higher lipid yields (16.33 and 14...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28492670/dietary-krill-oil-enhances-neurocognitive-functions-and-modulates-proteomic-changes-in-brain-tissues-of-d-galactose-induced-aging-mice
#13
Ling-Zhi Cheong, Tingting Sun, Yanyan Li, Jun Zhou, Chenyang Lu, Ye Li, Zhongbai Huang, Xiurong Su
The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of d-galactose-induced aging mice were evaluated. Dietary krill oil enhanced the neurocognitive functions of aging mice with a significant (P < 0.05) decrease in escape latency and an increase in the number of times of crossing over the hidden platform during the Morris water maze test. Krill oil was also found to protect against oxidative damage, lipid peroxidation and neurodegenerative diseases. Oxidative stress biomarkers of aging mice administered with krill oil showed significant (P < 0...
May 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28371906/lipid-modifying-effects-of-krill-oil-in-humans-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Sorin Ursoniu, Amirhossein Sahebkar, Maria-Corina Serban, Diana Antal, Dimitri P Mikhailidis, Arrigo Cicero, Vasilios Athyros, Manfredi Rizzo, Jacek Rysz, Maciej Banach
Context: Some experimental and clinical trials have shown that krill oil, extracted from small red crustaceans, might be an effective lipid-modifying agent, but the evidence is not conclusive. Objective: The effect of krill oil supplements on plasma lipid concentrations was assessed through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Data sources: PubMed and Scopus were searched up to March 25, 2016, to identify RCTs investigating the effect of krill oil supplements on plasma lipids...
May 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28334508/dietary-fatty-acids-influence-sperm-quality-and-function
#15
A Ferramosca, N Moscatelli, M Di Giacomo, V Zara
Recently, obesity has been linked to male infertility. In animal models the administration of a high-fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high-fat diet. Sexually mature male Sprague-Dawley rats were divided into four groups and fed for 4 weeks a standard diet (control group), a high-fat diet (enriched in 35% of fat and 15% sucrose), a high-fat diet supplemented with 2...
May 2017: Andrology
https://www.readbyqxmd.com/read/28294970/krill-oil-in-water-emulsion-protects-against-lipopolysaccharide-induced-proinflammatory-activation-of-macrophages-in-vitro
#16
Gabriel A Bonaterra, David Driscoll, Hans Schwarzbach, Ralf Kinscherf
BACKGROUND: Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phases of critical illness. Concerning anti-inflammatory properties in this setting, omega-3 fatty acids of marine origin have been frequently described. This study investigated the anti-inflammatory and LPS-inactivating properties of krill oil (KO)-in-water emulsion in human macrophages in vitro...
March 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28237087/e-configuration-structures-of-epa-and-dha-derived-from-euphausia-superba-and-their-significant-inhibitive-effects-on-growth-of-human-cancer-cell-lines-in-vitro
#17
Weilong Zheng, Xudong Wang, Wenjing Cao, Bowen Yang, Ying Mu, Yuesheng Dong, Zhilong Xiu
Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28107816/the-time-course-of-erythrocyte-membrane-fatty-acid-concentrations-during-and-after-treatment-of-non-human-primates-with-increasing-doses-of-an-omega-3-rich-phospholipid-preparation-derived-from-krill-oil
#18
Petter-Arnt Hals, Xiaoli Wang, Fabiana Piscitelli, Vincenzo Di Marzo, Yong-Fu Xiao
BACKGROUND: A commonly used measure to reflect the intake of the long-chain omega-3 fatty acids EPA and DHA is the omega-3 index, defined as the sum of EPA + DHA as % of total fatty acids in erythrocyte membrane. When the omega-3 index changes it follows that the relative fractions of other fatty acids in the membrane are also changed. In the present study, increasing doses of a preparation of omega-3 rich phospholipids extracted from krill oil were administered orally to non-human primates for 12 weeks and the time course of EPA, DHA and 22 other fatty acids in erythrocytes was determined bi-weekly during treatment and for 8 weeks after cessation of treatment...
January 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28095913/effects-of-a-purified-krill-oil-phospholipid-rich-in-long-chain-omega-3-fatty-acids-on-cardiovascular-disease-risk-factors-in-non-human-primates-with-naturally-occurring-diabetes-type-2-and-dyslipidemia
#19
Petter-Arnt Hals, Xiaoli Wang, Yong-Fu Xiao
BACKGROUND: High serum levels of cholesterol, in particular low-density lipoprotein cholesterol, are considered a significant risk factor for development of cardiovascular disease. Therefore, rigorous treatment regimens with statins and other pharmaceuticals have been used extensively to reduce elevated cholesterol levels. Literature data have not clearly concluded whether long-chain omega-3 fatty acids reduce, increase or leave circulating cholesterol unaffected. In the present study a novel krill-oil derived preparation of omega-3 rich phospholipids, mainly phosphatidylcholine, was administered orally at increasing doses for 12 weeks to dyslipidemic non-human primates, and cholesterols and several other risk factors for cardiovascular disease were measured before, during and after treatment...
January 17, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28078500/effects-of-different-omega-3-sources-fish-oil-krill-oil-and-green-lipped-mussel-against-cytokine-mediated-canine-cartilage-degradation
#20
Kittisak Buddhachat, Puntita Siengdee, Siriwadee Chomdej, Kumpanart Soontornvipart, Korakot Nganvongpanit
Our purpose was to evaluate the protective effect of three marine omega-3 sources, fish oil (FO), krill oil (KO), and green-lipped mussel (GLM) against cartilage degradation. Canine cartilage explants were stimulated with either 10 ng/mL interleukin-1β (IL-1β) or IL-1β/oncostatin M (10 ng/mL each) and then treated with various concentrations of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA; 3 and 30 μg/mL), FO, KO, or GLM (250, 500, and 1000 μg/mL) for 28 days. Gene expression was then investigated in primary canine chondrocytes...
May 2017: In Vitro Cellular & Developmental Biology. Animal
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