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https://www.readbyqxmd.com/read/29135343/effects-of-influenza-immunization-on-pneumonia-in-the-elderly
#1
Jung Yeon Heo, Joon Young Song, Ji Yun Noh, Min Joo Choi, Jin Gu Yoon, Saem Na Lee, Hee Jin Cheong, Woo Joo Kim
Influenza virus is a common pathogen implicated in respiratory tract infections, annually affecting up to 20% of the general population, and pneumonia is a leading cause of death after influenza infection. Post-influenza pneumonia is especially common in the elderly and chronically ill patients. The risk of post-influenza pneumonia is significantly increased according to the number of concurrent comorbidities. Vaccination is the primary measure used to abate influenza epidemics and associated complications...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29117525/membrane-cholesterol-reduces-polymyxin-b-nephrotoxicity-in-renal-membrane-analogs
#2
Adree Khondker, Richard J Alsop, Alexander Dhaliwal, Sokunthearath Saem, Jose M Moran-Mirabal, Maikel C Rheinstädter
Polymyxin B (PmB) is a "last-line" antibiotic scarcely used due to its nephrotoxicity. However, the molecular basis for antibiotic nephrotoxicity is not clearly understood. We prepared kidney membrane analogs of detergent-susceptible membranes, depleted of cholesterol, and cholesterol enriched, resistant membranes. In both analogs, PmB led to membrane damage. By combining x-ray diffraction, molecular dynamics simulations, and electrochemistry, we present evidence for two populations of PmB molecules: peptides that lie flat on the membranes, and an inserted state...
November 7, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29104713/quantile-regression-in-linear-mixed-models-a-stochastic-approximation-em-approach
#3
Christian E Galarza, Victor H Lachos, Dipankar Bandyopadhyay
This paper develops a likelihood-based approach to analyze quantile regression (QR) models for continuous longitudinal data via the asymmetric Laplace distribution (ALD). Compared to the conventional mean regression approach, QR can characterize the entire conditional distribution of the outcome variable and is more robust to the presence of outliers and misspecification of the error distribution. Exploiting the nice hierarchical representation of the ALD, our classical approach follows a Stochastic Approximation of the EM (SAEM) algorithm in deriving exact maximum likelihood estimates of the fixed-effects and variance components...
2017: Statistics and its Interface
https://www.readbyqxmd.com/read/29095281/disease-burden-of-hospitalized-community-acquired-pneumonia-in-south-korea-analysis-based-on-age-and-underlying-medical-conditions
#4
Min Joo Choi, Joon Young Song, Ji Yun Noh, Jin Gu Yoon, Saem Na Lee, Jung Yeon Heo, Jae Won Yoon, Yu Mi Jo, Hee Jin Cheong, Woo Joo Kim
Pneumonia is a leading cause of hospitalization and mortality worldwide. Despite recognition of the importance of community-acquired pneumonia (CAP) in adults, limited epidemiologic information is available in South Korea. This study aimed to evaluate the disease burden of hospitalized CAP in adults aged ≥19 years and its epidemiologic trend using Health Insurance and Review Assessment (HIRA) data.This is a retrospective study using the HIRA database from year 2009 to 2013. We estimated the incidence rate and direct medical cost of hospitalized CAP in adults aged ≥19 years in South Korea...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28981996/clinical-vignettes-inadequate-to-assess-impact-of-implicit-bias-concerning-limitations-of-a-systematic-review
#5
Elizabeth A Samuels, Dowin H Boatright, Leon Sanchez, Sheryl Heron, Aisha T Liferidge, Taneisha Wilson, Ava Pierce, Alden Landry, Lisa Moreno-Walton, Jeffrey Druck, Joel Moll, Bernard Lopez
We are writing in response to Dehon et al's article "A Systematic Review of the Impact of Physician Implicit Racial Bias on Clinical Decision Making"(1) in the August 2017 issue of Academic Emergency Medicine. As members of SAEM's Academy of Diversity and Inclusion in Emergency Medicine, we believe it is imperative to pursue research on the impact of bias and discrimination on clinical practice and healthcare outcomes. While we commend Dr. Dehon and her colleagues for their effort to assess the impact of implicit bias on clinical decision-making, we do not think that the evidence reviewed supports the breadth of their conclusions...
October 5, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28940436/in-reply
#6
Erin Dehon, Nicole Weiss, Sarah A Sterling
We appreciate the comments and concerns raised by members of SAEM's Academy of Diversity and Inclusion in Emergency Medicine(1) regarding the findings of our article, "A Systematic Review of the Impact of Physician Implicit Racial Bias on Clinical Decision Making."(2) We agree with Samuels et al.(1) that there are notable methodological limitations of earlier studies examining the influence of physician implicit bias on clinical decision making that must be considered when interpreting the findings of our systematic review...
September 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28939406/comparison-of-fixed-dose-combinations-of-amlodipine-losartan-potassium-chlorthalidone-and-amlodipine-losartan-potassium-in-patients-with-stage-2-hypertension-inadequately-controlled-with-amlodipine-losartan-potassium-a-randomized-double-blind-multicenter-phase
#7
Soon Jun Hong, Han Saem Jeong, Seung Hwan Han, Ki Yuk Chang, Bum Kee Hong, Bong Ki Lee, Shung Chull Chae, Woo Shik Kim, Chang Gyu Park, Jung Ho Heo, Seung Uk Lee, Young Dae Kim, Kee Sik Kim, Jung Hyun Choi, Hyun Jae Kang, Jae Joong Kim, Seok Min Kang, Young Jin Choi, Joon Han Shin, Kook Jin Chun, Dong Gu Shin, Seong Hoon Park, Jun Kwan, Yu Jeong Choi, Myung Ho Jeong, Jei Keon Chae, Dong Woon Kim, Jung Rae Cho, Kyoo Rok Han, Kyung Heon Won, Sang Ho Park, Sang Kon Lee, Sang Hoon Kim, Jina Jung, Cheol Ho Kim
PURPOSE: The goal of this study was to compare the efficacy and safety of fixed-dose combinations of amlodipine/losartan potassium/chlorthalidone (A/L/C) and A/L in Korean patients with stage 2 hypertension inadequately controlled by A/L. METHODS: This study was an 8-week, randomized double-blind, multicenter, phase III clinical trial. Three hundred forty volunteer patients with stage 2 hypertension were randomized to receive A/L/C or A/L. The primary end point was a change in sitting systolic blood pressure (SitSBP) after 8 weeks of treatment...
September 19, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28934255/quantitative-optical-coherence-tomography-angiography-of-macular-vascular-structure-and-foveal-avascular-zone-in-glaucoma
#8
Jaewan Choi, Junki Kwon, Joong Won Shin, Jiyun Lee, Saem Lee, Michael S Kook
OBJECTIVE: The study aimed to evaluate the quantitative characteristics of the macular vessel density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional, age- and sex-matched case-control study. METHODS: Fifty-two eyes of 52 patients with primary open angle glaucoma and 52 eyes from 52 healthy participants were recruited retrospectively. OCT-A was performed on a 3 x 3-mm macular region centered on the fovea...
2017: PloS One
https://www.readbyqxmd.com/read/28932095/erratum-treatment-and-classification-of-nevus-of-ota-a-seven-year-review-of-a-single-institution-s-experience
#9
Jae-Hui Nam, Han-Saem Kim, Young Jun Choi, Ho Joo Jung, Won-Serk Kim
[This corrects the article on p. 446 in vol. 29, PMID: 28761293.].
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28915347/re-saem-annual-meeting-abstracts
#10
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28838475/comparison-of-ticagrelor-versus-prasugrel-for-inflammation-vascular-function-and-circulating-endothelial-progenitor-cells-in-diabetic-patients-with-non-st-segment-elevation-acute-coronary-syndrome-requiring-coronary-stenting-a-prospective-randomized-crossover
#11
Han Saem Jeong, Soon Jun Hong, Sang-A Cho, Jong-Ho Kim, Jae Young Cho, Seung Hun Lee, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
OBJECTIVES: This study compared adenosine-associated pleiotropic effects of the 2 P2Y12 receptor antagonists on vascular function, systemic inflammation, and circulating endothelial progenitor cells (EPCs). BACKGROUND: Both ticagrelor and prasugrel have potent antiplatelet effects. However, only ticagrelor inhibits cellular uptake of adenosine. METHODS: Using a randomized, crossover design with 10-week follow-up ticagrelor or prasugrel was administered to type 2 diabetic patients with non-ST-segment elevation acute coronary syndrome requiring stent implantation...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28769087/bifunctional-hydrous-ruo2-nanocluster-electrocatalyst-embedded-in-carbon-matrix-for-efficient-and-durable-operation-of-rechargeable-zinc-air-batteries
#12
Han-Saem Park, Eunyong Seo, Juchan Yang, Yeongdae Lee, Byeong-Su Kim, Hyun-Kon Song
Ruthenium oxide (RuO2) is the best oxygen evolution reaction (OER) electrocatalyst. Herein, we demonstrated that RuO2 can be also efficiently used as an oxygen reduction reaction (ORR) electrocatalyst, thereby serving as a bifunctional material for rechargeable Zn-air batteries. We found two forms of RuO2 (i.e. hydrous and anhydrous, respectively h-RuO2 and ah-RuO2) to show different ORR and OER electrocatalytic characteristics. Thus, h-RuO2 required large ORR overpotentials, although it completed the ORR via a 4e process...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761293/treatment-and-classification-of-nevus-of-ota-a-seven-year-review-of-a-single-institution-s-experience
#13
Jae-Hui Nam, Han-Saem Kim, Young Jun Choi, Ho Joo Jung, Won-Serk Kim
BACKGROUND: Nevus of Ota (NO) is a relatively common pigmentary disorder in Asians. Tanino's classification is an old but tacit consensus to delineate the disease. Various treatment options have been presented. However, a few studies have been conducted on available laser options and current treatment strategies or the classification of NO. OBJECTIVE: To investigate current laser options and their effectiveness for the treatment of NO, contributing factors to clinical outcomes, and verification of classification...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28761290/beneficial-effect-of-low-fluence-1-064-nm-q-switched-neodymium-yttrium-aluminum-garnet-laser-in-the-treatment-of-senile-lentigo
#14
Jae-Hui Nam, Han-Saem Kim, Ga-Young Lee, Won-Serk Kim
BACKGROUND: Low fluence 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment, also known as laser toning, is widely used for pigmentary disorders. There has been no reliable evaluation of the effect of low fluence 1,064 nm QS Nd:YAG laser for senile lentigo. OBJECTIVE: To investigate the beneficial effect of low fluence 1,064 nm QS Nd:YAG laser in the treatment of senile lentigo on the face. METHODS: A retrospective review was conducted on patients treated only with repetitive low fluence 1,064 nm QS Nd:YAG laser...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28723782/endovascular-balloon-angioplasty-versus-stenting-in-patients-with-takayasu-arteritis-a-meta-analysis
#15
REVIEW
Han Saem Jeong, Jae Hyun Jung, Gwan Gyu Song, Sung Jae Choi, Soon Jun Hong
BACKGROUND: Symptomatic or significant vascular lesions of Takayasu arteritis (TA) need interventions. Although percutaneous transluminal angioplasty with balloon is a less invasive and safe method, stent implantation in TA can be an alternative option. However, superiority between balloon angioplasty and stenting in TA is not conclusive. METHODS: A meta-analysis comparing balloon angioplasty and stenting outcomes was performed using the MEDLINE and EMBASE databases...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682021/causes-and-surgical-outcomes-of-lower-eyelid-retraction
#16
Kun Hae Kim, Ji Sun Baek, Saem Lee, Jung Hye Lee, Hye Sun Choi, Sung Joo Kim, Jae Woo Jang
PURPOSE: To investigate the causes of lower eyelid retraction and evaluate the outcomes of various surgical procedures. METHODS: We conducted a retrospective medical record review of patients who underwent lower eyelid retraction surgery performed by a single surgeon at Kim's Eye Hospital between 2006 and 2013. We investigated the causes of lower eyelid retraction, clinical history, characteristics, treatment, and surgical outcomes. Preoperative and postoperative margin reflex distance 2 and inferior scleral show were measured for each eyelid...
August 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28636759/rosacea-and-its-association-with-enteral-microbiota-in-korean-females
#17
Jae-Hui Nam, Yeojun Yun, Han-Saem Kim, Han-Na Kim, Ho Joo Jung, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim, Won-Serk Kim
Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota. A cross-sectional study was performed in a sample of Korean women who participated in a health check-up programme at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28628260/society-for-academic-emergency-medicine-statement-on-plagiarism
#18
Shellie L Asher, Kenneth V Iserson, Lisa H Merck
The integrity of the research enterprise is of the utmost importance for the advancement of safe and effective medical practice for patients and for maintaining the public trust in health care. Academic societies and editors of journals are key participants in guarding scientific integrity. Avoiding and preventing plagiarism helps to preserve the scientific integrity of professional presentations and publications. The Society for Academic Emergency Medicine (SAEM) Ethics Committee discusses current issues in scientific publishing integrity and provides a guideline to avoid plagiarism in SAEM presentations and publications...
June 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28608661/campylobacter-jejuni-bacteremia-in-a-liver-cirrhosis-patient-and-review-of-literature-a-case-study
#19
Jin Gu Yoon, Saem Na Lee, Hak Jun Hyun, Min Joo Choi, Ji Ho Jeon, Eunju Jung, Seonghui Kang, Jeeyong Kim, Ji Yun Noh, Won Suk Choi, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28535610/nitric-oxide-inhibition-and-procollagen-type-i-peptide-synthesis-activities-of-a-phenolic-amide-identified-from-the-stem-of-lycium-chinense-miller
#20
Chan Saem Gil, Moon Sik Chang, Seok Hyun Eom
The bioactivities of boxthron fruits, a source of oriental medicine, are well known, whereas phytochemical studies of the boxthorn stem are rare. In this study, the stem extract of boxthorn (Lycium chinense Miller) and its subfractions were evaluated for their effects on nitric oxide (NO) inhibition and procollagen type I peptide (PIP) synthesis. A phenolic amide isolated from the stem extract was also assayed for these effects. The compound, N-trans-feruloyltyramine, was identified by (1)H, (13)C, and 2D-nuclear magnetic resonance analyses...
August 28, 2017: Journal of Microbiology and Biotechnology
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