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https://www.readbyqxmd.com/read/29738616/commentary-2018-stroke-guidelines
#1
Andrew D Perron
I read with interest (and some degree of disappointment) the new 2018 Stroke Guidelines published in January of this year that are labeled prominently "Endorsed by SAEM".1 To be clear, my disappointment has nothing to do with the use of tPA in acute ischemic stroke (I am happy to let others lead that charge). I am an admitted agnostic when it comes to the use of tPA (it helps some, it harms others, and we need to be really smart in its use to maximize the former and minimize the latter). Rather, it was notable to me that while the new guidelines touch a large number of specialties (Internal Medicine, Pharmacy, Nutrition, Rehabilitation, Radiology, Neurology, and Interventionalists to name a few), only one specialty merited a new Level 1A recommendation for targeted education This article is protected by copyright...
May 8, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29732144/evaluation-of-the-physicochemical-and-biological-stability-of-reconstituted-and-diluted-sb2-infliximab
#2
Jihyun Kim, Jihyun Chung, Sujin Park, Saem Jung, Dukwon Kang
Objectives: To evaluate the critical quality attributes that might affect the stability of an infliximab biosimilar (SB2, Flixabi) when reconstituted or diluted and stored under refrigeration and at room temperature. Methods: We largely adhered to the UK's National Health Service guidance requirements for the design of a robust stability study and for robust testing methods. Protocol components included evaluation of visual appearance, chemical stability, physical stability, pH, particle sizes and biological activity...
May 2018: European Journal of Hospital Pharmacy. Science and Practice
https://www.readbyqxmd.com/read/29704913/effects-of-oral-contraceptives-on-rheumatoid-arthritis-in-korean-menopausal-women-a-nationwide-cross-sectional-study
#3
Han Saem Jeong, Soon Jun Hong, Sung Jae Choi, Jae-Hoon Kim, Gwan Gyu Song, Jae Hyun Jung
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease with a multifactorial etiology. The higher prevalence of RA in women than in men may originate from differences in sex hormone levels or types. Ethnicity may interact with hormonal factors to produce various observed differences in the prevalence of RA. Oral contraceptives (OCs) are a source of exogenous sex hormones and can affect the prevalence of RA. We investigated the effects of OCs on RA in Korean menopausal women using a national data set...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29628667/early-predictive-factors-of-hypofibrinogenemia-in-acute-trauma-patients
#4
Shahram Paydar, Behnam Dalfardi, Zahra Shayan, Leila Shayan, Jalal Saem, Shahram Bolandparvaz
Background: Uncontrolled hemorrhage still remains a major cause of trauma-associated mortality. The events resulting in acute traumatic coagulopathy, particularly hypofibrinogenemia, make control of bleeding difficult. It is essential to timely predict, diagnose, and manage trauma-induced coagulopathy. Aims: The aim of this study is to determine clinical and easily available laboratory variables that are predictive of hypofibrinogenemia in acute trauma patients...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29625514/current-practices-of-percutaneous-coronary-intervention-in-korea-between-2011-and-2015
#5
EDITORIAL
Han Saem Jeong, Soon Jun Hong
No abstract text is available yet for this article.
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29622513/endovascular-versus-open-surgical-intervention-in-patients-with-takayasu-s-arteritis-a-meta-analysis
#6
REVIEW
Jae Hyun Jung, Young Ho Lee, Gwan Gyu Song, Han Saem Jeong, Jae-Hoon Kim, Sung Jae Choi
OBJECTIVE/BACKGROUND: Although medical treatment has advanced, surgical treatment is needed to control symptoms of Takayasu's arteritis (TA), such as angina, stroke, hypertension, or claudication. Endovascular or open surgical intervention is performed; however, there are few comparative studies on these methods. This meta-analysis and systematic review aimed to examine the outcome of surgical treatment of TA. METHODS: A meta-analysis comparing outcomes of endovascular and open surgical intervention was performed using MEDLINE and Embase...
April 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29596444/incidence-and-case-fatality-rates-of-community-acquired-pneumonia-and-pneumococcal-diseases-among-korean-adults-catchment-population-based-analysis
#7
Jung Yeon Heo, Yu Bin Seo, Won Suk Choi, Jacob Lee, Jin Gu Yoon, Saem Na Lee, Min Joo Choi, Ji Yun Noh, Jin-Young Ahn, Hye Won Jeong, Hee Jin Cheong, Woo Joo Kim, Hee Young Lee, Joon Young Song
BACKGROUND: Pneumonia is a leading infectious cause of morbidity and mortality among adults. Pneumococcal pneumonia (PP) is the most common vaccine-preventable bacterial etiology of pneumonia. In this study, we estimated the incidence of community-acquired pneumonia (CAP) and pneumococcal diseases among Korean adults. METHODS: Clinical and microbiological databases from three hospitals were retrospectively reviewed to determine the incidence and case fatality rates of CAP and pneumococcal diseases in Korean adults aged ≥19 years from 2011 to 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29595686/risk-factors-and-outcomes-of-sepsis-induced-myocardial-dysfunction-and-stress-induced-cardiomyopathy-in-sepsis-or-septic-shock-a-comparative-retrospective-study
#8
COMPARATIVE STUDY
Han Saem Jeong, Tae Hyub Lee, Cho Hee Bang, Jong-Ho Kim, Soon Jun Hong
While both sepsis-induced myocardial dysfunction (SIMD) and stress-induced cardiomyopathy (SICMP) are common in patients with sepsis, the pathogenesis of the 2 diseases is different, and they require different treatment strategies. Thus, we aimed to investigate risk factors and outcomes between the 2 diseases.This retrospective study enrolled patients diagnosed with sepsis or septic shock, admitted to intensive care unit via emergency department in Korea University Anam Hospital, and who underwent transthoracic echocardiography within the first 24 hours of admission...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29577023/geostatistical-estimation-and-prediction-for-censored-responses
#9
José A Ordoñez, Dipankar Bandyopadhyay, Victor H Lachos, Celso R B Cabral
Spatially-referenced geostatistical responses that are collected in environmental sciences research are often subject to detection limits, where the measures are not fully quantifiable. This leads to censoring (left, right, interval, etc), and various ad hoc statistical methods (such as choosing arbitrary detection limits, or data augmentation) are routinely employed during subsequent statistical analysis for inference and prediction. However, inference may be imprecise and sensitive to the assumptions and approximations involved in those arbitrary choices...
March 2018: Spatial Statistics
https://www.readbyqxmd.com/read/29556960/comprehensive-physicochemical-and-biological-characterization-of-the-proposed-biosimilar-darbepoetin-alfa-lbde-and-its-originator-darbepoetin-alfa-nesp-%C3%A2
#10
Yeong Ran Jeong, Rae Ung Jeong, Jeong Hyun Son, Joon Cheol Kwon, Saem Jung, Mi A Song, Jin Ah Hwang, Gyun Min Lee
BACKGROUND: For regulatory approval, the comparability of a biosimilar product to an originator product should be ensured through thorough physicochemical and biological characterization. OBJECTIVE: To evaluate the biosimilarity between LBDE, the proposed biosimilar darbepoetin alfa, and NESP® , its originator, we performed a comprehensive physicochemical and biological characterization study. METHODS: Primary and higher-order protein structures were analyzed using Lys-C peptide mapping with liquid chromatography-mass spectrometry (LC-MS), disulfide bond identification, circular dichroism, and fluorescence spectroscopy...
March 19, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29402522/a-phase-iii-multicenter-randomized-double-blind-active-comparator-clinical-trial-to-compare-the-efficacy-and-safety-of-combination-therapy-with-ezetimibe-and-rosuvastatin-versus-rosuvastatin-monotherapy-in-patients-with-hypercholesterolemia-i-rosette-ildong
#11
Soon Jun Hong, Han Saem Jeong, Jeong Cheon Ahn, Dong-Hun Cha, Kyung Heon Won, Weon Kim, Sang Kyoon Cho, Seok-Yeon Kim, Byung-Su Yoo, Ki Chul Sung, Seung-Woon Rha, Joon-Han Shin, Kyoo Rok Han, Wook Sung Chung, Min Su Hyon, Han Cheol Lee, Jang-Ho Bae, Moo-Yong Rhee, Jun Kwan, Dong Woon Jeon, Ki Dong Yoo, Hyo-Soo Kim
PURPOSE: Combination therapy with ezetimibe and statins is recommended in cases of statin intolerance or insufficiency. The objective of this study was to compare the efficacy and safety of combination therapy with ezetimibe and rosuvastatin versus those of rosuvastatin monotherapy in patients with hypercholesterolemia. METHODS: I-ROSETTE (Ildong ROSuvastatin & ezETimibe for hypercholesTElolemia) was an 8-week, double-blind, multicenter, Phase III randomized controlled trial conducted at 20 hospitals in the Republic of Korea...
February 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29366130/effects-of-black-raspberry-on-lipid-profiles-vascular-endothelial-function-and-circulating-endothelial-progenitor-cells-in-patients-with-metabolic-syndrome
#12
Soon Jun Hong, Han Saem Jeong
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29207558/three-new-cytotoxic-steroidal-glycosides-isolated-from-conus-pulicarius-collected-in-kosrae-micronesia
#13
Yeon-Ju Lee, Saem Han, Su Hyun Kim, Hyi-Seung Lee, Hee Jae Shin, Jong Seok Lee, Jihoon Lee
Three new sulfated steroidal glycosides ( 3 - 5 ), along with known cholesterol derivatives ( 1 , 2 ), were isolated from the visceral extract of the cone snail Conus pulicarius . The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 μM) against the K562 human leukemia cell line.
December 4, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29206202/bioconverted-orostachys-japonicas-extracts-suppress-angiogenic-activity-of-ms-1-endothelial-cells
#14
Seul Gi Lee, Jin Soo Kim, Han-Saem Lee, Yu-Mi Lim, Jai-Hyun So, Dongyup Hahn, Yu Shin Ha, Ju-Ock Nam
Orostachys japonicus A. Berger (), known as Wa-song in Korea, has been reported to exert various biological effects, such as anti-tumor, anti-oxidant, and anti-febrile effects. However, the anti-angiogenic effects of O. japonicus extracts remain to be investigated. In the present study, we demonstrated the anti-angiogenic effects of bioconverted O. japonicus extract (BOE) in Ms-1 mouse endothelial cells and compared them with the bioactivities of O. japonicus extract (OE). BOE, but not OE, were found to exert anti-angiogenic effects, including inhibition of cell migration, cell adhesion, tube formation of Ms-1 cells, and blood vessel formation of matrigel plug assay in vivo...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29169218/laccase-fermentation-of-clove-extract-increases-content-of-dehydrodieugenol-which-has-neuroprotective-activity-against-glutamate-toxicity-in-ht22-cells
#15
Han-Saem Lee, Eun-Ju Yang, Taeho Lee, Kyung-Sik Song
Enzyme fermentation is a type of food processing technique generally used to improve the biological activities of food and herbal medicines. In this study, a Syzygii Flos (clove) extract was fermented using laccase derived from Trametes versicolor (LTV). The fermented clove extract showed greater neuroprotective effects against glutamate toxicity on HT22 than the non-fermented extract did. HPLC analysis revealed that the eugenol (1) and dehydrodieugenol (2) contents had decreased and increased, respectively, after fermentation...
February 28, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29135343/effects-of-influenza-immunization-on-pneumonia-in-the-elderly
#16
Jung Yeon Heo, Joon Young Song, Ji Yun Noh, Min Joo Choi, Jin Gu Yoon, Saem Na Lee, Hee Jin Cheong, Woo Joo Kim
Influenza virus is a common pathogen implicated in respiratory tract infections, annually affecting up to 20% of the general population, and pneumonia is a leading cause of death after influenza infection. Post-influenza pneumonia is especially common in the elderly and chronically ill patients. The risk of post-influenza pneumonia is significantly increased according to the number of concurrent comorbidities. Vaccination is the primary measure used to abate influenza epidemics and associated complications...
March 4, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29117525/membrane-cholesterol-reduces-polymyxin-b-nephrotoxicity-in-renal-membrane-analogs
#17
Adree Khondker, Richard J Alsop, Alexander Dhaliwal, Sokunthearath Saem, Jose M Moran-Mirabal, Maikel C Rheinstädter
Polymyxin B (PmB) is a "last-line" antibiotic scarcely used due to its nephrotoxicity. However, the molecular basis for antibiotic nephrotoxicity is not clearly understood. We prepared kidney membrane analogs of detergent-susceptible membranes, depleted of cholesterol, and cholesterol enriched, resistant membranes. In both analogs, PmB led to membrane damage. By combining x-ray diffraction, molecular dynamics simulations, and electrochemistry, we present evidence for two populations of PmB molecules: peptides that lie flat on the membranes, and an inserted state...
November 7, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29104713/quantile-regression-in-linear-mixed-models-a-stochastic-approximation-em-approach
#18
Christian E Galarza, Victor H Lachos, Dipankar Bandyopadhyay
This paper develops a likelihood-based approach to analyze quantile regression (QR) models for continuous longitudinal data via the asymmetric Laplace distribution (ALD). Compared to the conventional mean regression approach, QR can characterize the entire conditional distribution of the outcome variable and is more robust to the presence of outliers and misspecification of the error distribution. Exploiting the nice hierarchical representation of the ALD, our classical approach follows a Stochastic Approximation of the EM (SAEM) algorithm in deriving exact maximum likelihood estimates of the fixed-effects and variance components...
2017: Statistics and its Interface
https://www.readbyqxmd.com/read/29095281/disease-burden-of-hospitalized-community-acquired-pneumonia-in-south-korea-analysis-based-on-age-and-underlying-medical-conditions
#19
Min Joo Choi, Joon Young Song, Ji Yun Noh, Jin Gu Yoon, Saem Na Lee, Jung Yeon Heo, Jae Won Yoon, Yu Mi Jo, Hee Jin Cheong, Woo Joo Kim
Pneumonia is a leading cause of hospitalization and mortality worldwide. Despite recognition of the importance of community-acquired pneumonia (CAP) in adults, limited epidemiologic information is available in South Korea. This study aimed to evaluate the disease burden of hospitalized CAP in adults aged ≥19 years and its epidemiologic trend using Health Insurance and Review Assessment (HIRA) data.This is a retrospective study using the HIRA database from year 2009 to 2013. We estimated the incidence rate and direct medical cost of hospitalized CAP in adults aged ≥19 years in South Korea...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28981996/clinical-vignettes-inadequate-to-assess-impact-of-implicit-bias-concerning-limitations-of-a-systematic-review
#20
LETTER
Elizabeth A Samuels, Dowin Boatright, Leon D Sanchez, Sheryl L Heron, Aisha T Liferidge, Taneisha Wilson, Ava Pierce, Alden Landry, Lisa Moreno-Walton, Jeffrey Druck, Joel Moll, Bernard L Lopez
No abstract text is available yet for this article.
December 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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