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Jung-In Kim, Young-Jun Choi, Hyun-Min Seo, Han-Saem Kim, Jae Yun Lim, Dong-Hoon Kim, Seoung Wan Chae, Ga-Young Lee, Won-Serk Kim
Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3...
October 2016: Annals of Dermatology
Hyun-Min Seo, Jung-In Kim, Han-Saem Kim, Young-Jun Choi, Won-Serk Kim
BACKGROUND: Rosacea treatments including oral/topical medications and laser therapy are numerous but unsatisfactory. OBJECTIVE: To compare the effectiveness of the dual wavelength long-pulsed 755-nm alexandrite/1,064-nm neodymium: yttrium-aluminum-garnet laser (LPAN) with that of 585-nm pulsed dye laser (PDL) for rosacea. METHODS: This was a randomized, single-blinded, comparative study. Full face received four consecutive monthly treatments with LPAN or PDL, followed-up for 6 months after the last treatment...
October 2016: Annals of Dermatology
Jae-Young Han, Jae-Hong Kim, Ju-Hyung Park, Min-Yeong Song, Min-Keun Song, Dong-Joo Kim, Young-Nim You, Gwang-Cheon Park, Jin-Bong Choi, Myung-Rae Cho, Jeong-Cheol Shin, Ji-Hyun Cho
BACKGROUND: Scalp acupuncture (SA) and repetitive transcranial magnetic stimulation (rTMS) are effective for treating cerebral infarction. This study aims to examine the efficacy and safety of SA and electromagnetic convergence stimulation (SAEM-CS), which was developed through collaboration between conventional medical physicians and doctors who practice traditional Korean medicine. SAEM-CS was designed to improve function in patients with cerebral infarction, compared to the improvement after conventional stroke rehabilitation, SA, and rTMS therapeutic approaches...
October 11, 2016: Trials
Ai-Qun Yu, Nina Pratomo, Tee-Kheang Ng, Hua Ling, Han-Saem Cho, Susanna Su Jan Leong, Matthew Wook Chang
Yarrowia lipolytica is a non-pathogenic, dimorphic and strictly aerobic yeast species. Owing to its distinctive physiological features and metabolic characteristics, this unconventional yeast is not only a good model for the study of the fundamental nature of fungal differentiation but is also a promising microbial platform for biochemical production and various biotechnological applications, which require extensive genetic manipulations. However, genetic manipulations of Y. lipolytica have been limited due to the lack of an efficient and stable genetic transformation system as well as very high rates of non-homologous recombination that can be mainly attributed to the KU70 gene...
2016: Journal of Visualized Experiments: JoVE
Erica Frank, Kate Tairyan, Michelle Everton, Jennifer Chu, Craig Goolsby, Alisa Hayes, Ann Hulton
BACKGROUND: The WHO has called for the use of computer-aided education to train millions of additional health providers. We herein address this appeal with the first globally available, free, accredited, computer-aided, and peer and mentor-guided course. METHODS: The intervention studied was's first course, "Emergency Medicine (EM) for Senior Medical Students", required for the graduating Classes of 2013 at the University of Missouri (UM) and the U...
September 20, 2016: Healthcare
Setha Limsreng, Olivier Marcy, Sowath Ly, Vara Ouk, Hak Chanroeurn, Saem Thavary, Ban Boroath, Ana Canestri, Gérald Viretto, Jean-François Delfraissy, Olivier Ségéral
BACKGROUND: Lopinavir/ritonavir (LPV/r) is widely used in Cambodia with high efficacy but scarce data exist on long-term metabolic toxicity. METHODS: We carried out a cross-sectional and retrospective study evaluating metabolic disorders and cardiovascular risk in Cambodian patients on LPV/r-based antiretroviral therapy (ART) for > 1 year followed in Calmette Hospital, Phnom Penh. Data collected included cardiovascular risk factors, fasting blood lipids and glucose, and retrospective collection of bioclinical data...
2016: PloS One
Tat-Ming Lo, Si Hui Chng, Wei Suong Teo, Han-Saem Cho, Matthew Wook Chang
We present a synthetic gene circuit for decoupling cell growth from metabolite production through autonomous regulation of enzymatic pathways by integrated modules that sense nutrient and substrate. The two-layer circuit allows Escherichia coli to selectively utilize target substrates in a mixed pool; channel metabolic resources to growth by delaying enzymatic conversion until nutrient depletion; and activate, terminate, and re-activate conversion upon substrate availability. We developed two versions of controller, both of which have glucose nutrient sensors but differ in their substrate-sensing modules...
August 2016: Cell Systems
Mathew Nelson, Amin Abdi, Srikar Adhikari, Michael Boniface, Robert M Bramante, Daniel J Egan, J Matthew Fields, J Matthew Fields, Megan M Leo, Andrew S Liteplo, Rachel Liu, Jason T Nomura, David C Pigot, Christopher C Raio, Jennifer Ruskis, Robert Strony, Chris Thom, Resa Lewiss
In 2012 the Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Emergency Medicine (ABEM) released the Emergency Medicine (EM) Milestones. The Patient Care 12 (PC12) subcompetency delineates staged and progressive accomplishment in emergency ultrasound (EUS). While valuable as an initial framework for ultrasound resident education, there are limitations to PC12. This consensus paper provides a revised description of criteria to define the subcompetency. A multi-organizational taskforce was formed between the American College of Emergency Physicians (ACEP) Ultrasound Section, the Council of Emergency Medicine Residency Directors (CORD), and the Academy of Emergency Ultrasound (AEUS) of the Society for Academic Emergency Medicine (SAEM)...
August 13, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Darryl Fong, William J Bodnaryk, Nicole A Rice, Sokunthearath Saem, Jose M Moran-Mirabal, Alex Adronov
The separation and isolation of semiconducting and metallic single-walled carbon nanotubes (SWNTs) on a large scale remains a barrier to many commercial applications. Selective extraction of semiconducting SWNTs by wrapping and dispersion with conjugated polymers has been demonstrated to be effective, but the structural parameters of conjugated polymers that dictate selectivity are poorly understood. Here, we report nanotube dispersions with a poly(fluorene-co-pyridine) copolymer and its cationic methylated derivative, and show that electron-deficient conjugated π-systems bias the dispersion selectivity toward metallic SWNTs...
October 4, 2016: Chemistry: a European Journal
Motohiro Nakajima, Anisa Dokam, Najat Saem Khalil, Mohammed Alsoofi, Mustafa al'Absi
BACKGROUND: Habitual substance use poses public health threat. This is a growing concern in countries where one or more substances are commonly used. Many individuals in Middle Eastern and East African countries use khat (Catha edulis), a stimulant often accompanied by smoking. However, few systematic attempts have been made to characterize patterns of concurrent khat and tobacco use. OBJECTIVES: To examine correlates such as gender and patterns of khat and tobacco use in concurrent users and khat-only users...
October 14, 2016: Substance Use & Misuse
Seong Chan Choi, Saem Lee, Hye Sun Choi, Jae Woo Jang, Sung Joo Kim, Jung Hye Lee
PURPOSE: To identify and analyze the role of preoperative computed tomography (CT) in patients with tearing symptoms with nasolacrimal duct obstruction (NLDO). METHODS: We retrospectively reviewed the medical records and CT results on 218 patients who complained of tearing symptoms with NLDO between January 2014 and December 2014. All patients were recruited from Kim's Eye Hospital's outpatient clinic and assessed by clinical history, examination, and CT to evaluate periocular pathology and nasolacrimal drainage system...
August 2016: Korean Journal of Ophthalmology: KJO
Rebecca Wright, Patricia J Skolnik, David M Skolnik, Corita Grudzen
The Society for Academic Emergency Medicine (SAEM) consensus conference provided many platforms for patient advocates to share their experiences and demonstrate the powerful contribution they have to offer to the decision-making process. One such platform was the presentation of a film 'The Faces of Medical Error: From Tears to Transparency' shared by Patty and David Skolnik. In this article the Skolniks build on their story shared at the SAEM consensus conference and the panel discussion. They provide further insight drawn from nine years of experiences as advocates for patient safety, including their reflections on working with, training and educating medical professionals, lawmakers, and consumers in shared decision-making and informed consent...
July 11, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Hyun-Min Seo, Hyung-Geun Min, Hee-Joong Kim, Jong-Hun Shin, Sang-Ho Nam, Kwang-Soo Han, Joung-Ho Ryu, Jeong-Joon Oh, Ji Young Kim, Kwang-Joon Lee, Seung Jae Lee, Han-Saem Kim, Jung-In Kim, Min-Kyu Song, Won-Serk Kim
BACKGROUND: Indocyanine green (ICG) is a photosensitizer recently introduced for the treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of photodynamic therapy (PDT) using ICG in subjects with acne vulgaris and to evaluate whether there was a difference in the efficacy of ICG-PDT between different numbers of treatment. MATERIALS AND METHODS: Subjects with acne on the face were included. ICG lotion (0.1%) was applied for 30 minutes, and a long pulse diode laser was used...
October 2016: International Journal of Dermatology
Ji Yun Noh, Yu Bin Seo, Joon Young Song, Won Suk Choi, Jacob Lee, Eunju Jung, Seonghui Kang, Min Joo Choi, Jiho Jun, Jin Gu Yoon, Saem Na Lee, Hakjun Hyun, Jin-Soo Lee, Hojin Cheong, Hee Jin Cheong, Woo Joo Kim
Pregnant women are prioritized to receive influenza vaccination. However, the maternal influenza vaccination rate has been low in Korea. To identify potential barriers for the vaccination of pregnant women against influenza, a survey using a questionnaire on the perceptions and attitudes about maternal influenza vaccination was applied to Korean obstetricians between May and August of 2014. A total of 473 respondents participated in the survey. Most respondents (94.8%, 442/466) recognized that influenza vaccination was required for pregnant women...
July 2016: Journal of Korean Medical Science
Il Young Jung, Jae Bem You, Bo Ram Choi, Ji Su Kim, Hyun Kyung Lee, Bora Jang, Han Saem Jeong, Kyuri Lee, Sung Gap Im, Hyukjin Lee
Trail polymerization enables a significant enhancement of the DhITACT system. DhITACT-Trail (DNA hydrogel formation by isothermal amplification of complementary targets trail polymerization) offers a robust diagnosis of target RNA strands in pseudo-serum specimen. This system requires minimum liquid handling as compared to conventional analysis. In addition, a definitive diagnostic result can be achieved within 30 min by an optical detection.
September 2016: Advanced Healthcare Materials
Victoria Palmer-Smith, Katherine Ash
Dr. Ash faced what many of us do on an almost daily basis - a patient whose condition does not meet our definition of an emergency, whose use of an emergency department setting could be perceived as "inappropriate", who has had their "five minutes," and more than their share of tests, and is now an obstacle to us addressing the real emergency that lies lurking in our waiting room. The breakdown of communication she experienced is one of the great stressors of our specialty. SAEM appointed a task force in 1994 to explore physician-patient communication in the ED and presented its findings in Academic Emergency Medicine...
June 8, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Ji Sun Baek, Saem Lee, Jung Hye Lee, Hye Sun Choi, Jae Woo Jang, Sung Joo Kim
PURPOSE: To evaluate prognostic factors affecting silicone tube intubation outcomes in Asian patients with lacrimal drainage system stenosis. METHODS: A retrospective review was conducted on the medical records of 822 patients (1,118 eyes) who had undergone silicone tube intubation to treat lacrimal drainage system stenosis between January 2011 and December 2012. Patients were divided into two groups: a success group and a failure group. Success was defined as the disappearance of epiphora symptoms, normalization of tear meniscus height, and the easy passage of fluid without resistance on the postoperative syringing test...
June 2016: Korean Journal of Ophthalmology: KJO
Xiaoxi Liu, Yuhuan Wang
For the purpose of population pharmacometric modeling, a variety of mathematic algorithms are implemented in major modeling software packages to facilitate the maximum likelihood modeling, such as FO, FOCE, Laplace, ITS and EM. These methods are all designed to estimate the set of parameters that maximize the joint likelihood of observations in a given problem. While FOCE is still currently the most widely used method in population modeling, EM methods are getting more popular as the current-generation methods of choice because of their robustness with more complex models and sparse data structures...
August 2016: Journal of Pharmacokinetics and Pharmacodynamics
Solène Desmée, France Mentré, Christine Veyrat-Follet, Bernard Sébastien, Jérémie Guedj
Joint modeling is increasingly popular for investigating the relationship between longitudinal and time-to-event data. However, numerical complexity often restricts this approach to linear models for the longitudinal part. Here, we use a novel development of the Stochastic-Approximation Expectation Maximization algorithm that allows joint models defined by nonlinear mixed-effect models. In the context of chemotherapy in metastatic prostate cancer, we show that a variety of patterns for the Prostate Specific Antigen (PSA) kinetics can be captured by using a mechanistic model defined by nonlinear ordinary differential equations...
May 5, 2016: Biometrics
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