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https://www.readbyqxmd.com/read/29932039/effect-of-prolonged-anti-hm1-imss-entamoeba-histolytica-antibody-activity-in-humoral-and-cellular-immunity-of-experimentally-induced-animal-model
#1
Swati Bagde, Vinod Singh
BACKGROUND: The Cellular immunity plays an important role in amoebic infections, whereas humoral immune responses have little influence on the outcome of the disease. Chronic infestation with E. histolytica, a common protozoan parasite, has been associated with autoimmune phenomena, including the appearance of antibodies to colonic epithelial cells. The mechanism whereby the protozoan parasite E. histolytica causes suppression of the immune response to allow it to survive in humans is unclear...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29930803/stevens-johnsons-syndrome-or-drug-induced-lupus-a-clinical-dilemma-a-case-report-and-review-of-the-literature
#2
Violeta Claudia Bojinca, Mihai Bojinca, Madalina Gheorghe, Adelina Birceanu, Cristina Ileana Iosif, Serban Mihai Balanescu, Andra Rodica Balanescu
Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930511/elaeocarpusin-inhibits-mast-cell-mediated-allergic-inflammation
#3
Min-Jong Kim, Yeon-Yong Kim, Young-Ae Choi, Moon-Chang Baek, Byungheon Lee, Pil-Hoon Park, Tae-Yong Shin, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Mast cells are major effector cells for allergic responses that act by releasing inflammatory mediators, such as histamine and pro-inflammatory cytokines. Accordingly, different strategies have been pursued to develop anti-allergic and anti-inflammatory candidates by regulating the function of mast cells. The purpose of this study was to determine the effectiveness of elaeocarpusin (EL) on mast cell-mediated allergic inflammation. We isolated EL from Elaeocarpus sylvestris L. (Elaeocarpaceae), which is known to possess anti-inflammatory properties...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29929562/carbon-monoxide-releasing-molecule-3-protects-against-ischemic-stroke-by-suppressing-neuroinflammation-and-alleviating-blood-brain-barrier-disruption
#4
Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang, Jian Wang
BACKGROUND: At low levels, carbon monoxide (CO) has been shown to have beneficial effects on multiple organs and tissues through its potential anti-inflammatory, anti-apoptotic, and anti-proliferative properties. However, the effect of CO-releasing molecule (CORM)-3, a water-soluble CORM, on ischemic stroke and its mechanism of action are still unclear. METHODS: We investigated the role of CORM-3 in the mouse model of transient middle cerebral artery occlusion (tMCAO)...
June 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29928491/tnfaip8-promotes-prostate-cancer-cell-survival-by-inducing-autophagy
#5
Suryakant Niture, Malathi Ramalinga, Habib Kedir, Dorrelyn Patacsil, Samiksha S Niture, James Li, Haresh Mani, Simeng Suy, Sean Collins, Deepak Kumar
Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is a TNF-α inducible anti-apoptotic protein with multiple roles in tumor growth and survival. Mechanisms of cell survival by TNFAIP8 remain elusive. We investigated the role of TNFAIP8 in the regulation of the cell cycle, autophagy, cell survival and neuroendocrine differentiation in prostate cancer cells. We showed that TNFAIP8 dysregulates cell-cycle-related proteins, in PC3 cells. Oncogenic cell survival, drug resistance and dysregulation of cell cycle-related proteins are often associated with autophagy...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928397/construction-of-an-anti-programmed-death-ligand-1-chimeric-antigen-receptor-and-determination-of-its-antitumor-function-with-transduced-cells
#6
Jiasen Xie, Zishan Zhou, Shunchang Jiao, Xiaokun Li
A chimeric antigen receptor (CAR) is a type of fusion protein that comprises an antigen-recognition domain and signaling domains. In the present study, a programmed death-ligand 1 (PD-L1)-specific CAR, comprised of a single-chain variable fragment (scFv) derived from a monoclonal antibody, co-stimulatory domains of cluster of differentiation (CD) 28 and 4-1BB and a T-cell-activation domain derived from CD3ζ, was designed. The construction was cloned and packaged into the lentiviral vector pLVX. Flow cytometry confirmed that peripheral blood mononuclear cells were efficiently transduced and that the CAR was successfully expressed on T cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928231/carnosine-prevents-type-2-diabetes-induced-osteoarthritis-through-the-ros-nf-%C3%AE%C2%BAb-pathway
#7
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai
Background: The anti-inflammatory and antioxidant capacity of carnosine (CAR) has been investigated in autoimmune diseases. The aim of this study was to evaluate the potential protective effects of oral CAR supplements to ameliorate type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and its mechanism. Methods: Seventy male Sprague-Dawley rats were randomly divided into the control group (CG, n = 10) and the T2DM group ( n = 60). A rat model of T2DM was established using a high fat diet and streptozotocin (30 mg/kg, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29926673/-effect-of-fracture-of-lower-limbs-with-hemorrhage-on-myocardial-injury-and-its-mechanism-in-rats
#8
Zhao-Hui Li, Ying Zhang, Yan Lu, Qing-Ming Lu, Xiao-Hua Xie
OBJECTIVES: To test whether myocardial apoptosis can be induced by traumatic fracture of lower limbs with hemorrhage, in order to lay a foundation of myocardial injury after traumatic fracture for the follow-up study. METHODS: Twenty SD rats were randomly divided into two groups, i. e. control group and trauma group( n =10). A rat model of traumatic hemorrhage was establish, and a traumatic model of the original generation of myocardial cell culture was constructed in vitro ...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926660/-comparative-study-on-anti-inflammatory-and-immunomodulation-of-different-isatidis-radix-strains-growing-in-gansu-province
#9
Ze-Jun Zhao, Zhi-Wang Wang, Mei Guo, Tao Du, Xia Shi, Jing Shao, Xi-Yan Wen
OBJECTIVE: To investigate anti-inflammatory and immunomodulation effects of different ecotype from Isatidis Radix growing in Gansu province. METHODS: Mice were randomly divided into 6 groups ( n =11)and used the auricular swelling and paw edema to observe the anti-inflammatory effects of Isatidis Radix; Mice were randomly divided into 7 groups ( n =11) and through the gasbag synovitis model to observe the anti-inflammatory effects of Isatidis Radix; Mice were randomly divided into 6 groups ( n =11), the immunosuppressed model were established by injection of cyclophosphamide (CTX) to study the effects of Isatidis Radix on index of thymus, blood routine and cytokines...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29925913/no-benefit-of-concomitant-5-aminosalicylates-in-patients-with-ulcerative-colitis-escalated-to-biologic-therapy-pooled-analysis-of-individual-participant-data-from-clinical-trials
#10
Siddharth Singh, James A Proudfoot, Parambir S Dulai, Vipul Jairath, Mathurin Fumery, Ronghui Xu, Brian G Feagan, William J Sandborn
OBJECTIVES: 5-aminosalicylates (5-ASA) are frequently continued in patients with moderate-severe ulcerative colitis (UC), even after escalation to biologic agents, without evaluation of the benefit of this approach. We conducted an individual participant data (IPD) pooled analysis of trials of infliximab and golimumab in UC, to evaluate whether concomitant use of 5-ASA modifies clinical outcomes among anti-tumor necrosis factor (TNF)-α-treated patients. METHODS: We included IPD from five trials of infliximab and golimumab in patients with moderate-severe UC (ACT-1 and -2, PURSUIT-SC, PURSUIT-M, NCT00336492)...
June 21, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29925372/selenium-ameliorates-staphylococcus-aureus-induced-inflammation-in-bovine-mammary-epithelial-cells-by-inhibiting-activation-of-tlr2-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#11
Heng Wang, Chongliang Bi, Yinjie Wang, Jun Sun, Xia Meng, Jianji Li
BACKGROUND: Staphylococcus aureus (S. aureus) internalization into bovine mammary epithelial cells (bMECs) is considered an important pathogenic mechanism for the establishment of mastitis. Given the interesting link between selenium (Se) status and mastitis, our objective was to prove that Se was essential to suppress pro-inflammatory mediators, in part, by modulation of Toll-like receptor2 (TLR2), nuclear factor kappaB (NF-κB) and mitogen activated protein kinase (MAPK) signal transduction pathway in bMECs...
June 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29924731/il-37-affects-the-occurrence-and-development-of-endometriosis-by-regulating-the-biological-behavior-of-endometrial-stromal-cells-through-multiple-signaling-pathways
#12
Jianfa Jiang, Kenan Yu, Zhaoying Jiang, Min Xue
Endometriosis (EMs) is a chronic inflammatory condition. Interleukin (IL)-37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study aimed to evaluate the possible role of IL-37 in the EMs pathogenesis. We investigated the in vivo effect of IL-37 on EMs by injection with recombinant human IL-37 (rhIL-37) into EMs mice. Furthermore, we evaluated the in-vitro effects of IL-37 on proliferation, adhesion, migration, and invasiveness of endometrial stromal cells (ESCs), and explored whether Wnt/β-catenin and mitogen-activated protein kinase (MAPK) pathways were involved in this process...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924642/increased-cytokines-at-high-altitude-lack-of-effect-of-ibuprofen-on-acute-mountain-sickness-physiological-variables-or-cytokine-levels
#13
Jenny Lundeberg, John R Feiner, Andrew Schober, Jeffrey W Sall, Helge Eilers, Philip E Bickler
Lundeberg, Jenny, John R. Feiner, Andrew Schober, Jeffrey W. Sall, Helge Eilers, and Philip E. Bickler. Increased cytokines at high altitude: lack of effect of ibuprofen on acute mountain sickness, physiological variables or cytokine levels. High Alt Med Biol. 00:000-000, 2018. INTRODUCTION: There is no consensus on the role of inflammation in high-altitude acclimatization. AIMS: To determine the effects of a nonsteroidal anti-inflammatory drug (ibuprofen 400 mg every 8 hours) on blood cytokines, acclimatization, acute mountain sickness (AMS, Lake Louise Score), and noninvasive oxygenation in brain and muscle in healthy volunteers...
June 20, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29924019/case-report-successful-treatment-of-refractory-sapho-syndrome-with-the-jak-inhibitor-tofacitinib
#14
Qiao Yang, Yumo Zhao, Chen Li, Yaping Luo, Weixin Hao, Wen Zhang
INTRODUCTION: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disorder without standardized treatment. Janus kinase (JAK) inhibitors can block a range of cytokines and might possess significant anti-inflammatory activity. Here, we report the first case of efficacious treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib. CASE PRESENTATION: A 44-year-old woman presented with arthralgia in the right wrist and complained of having difficulty in doing housework...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922080/factors-correlated-with-the-improvement-of-endothelial-dysfunction-during-abatacept-therapy-in-patients-with-rheumatoid-arthritis
#15
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29921749/role-of-human-macrophage-polarization-in-inflammation-during-infectious-diseases
#16
REVIEW
Chiraz Atri, Fatma Z Guerfali, Dhafer Laouini
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1β, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-α cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-β, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22)...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29920582/early-mucosal-healing-predicts-favorable-outcomes-in-patients-with-moderate-to-severe-ulcerative-colitis-treated-with-golimumab-data-from-the-real-life-be-smart-cohort
#17
Peter Bossuyt, Filip Baert, Francois D'Heygere, Antoine Nakad, Catherine Reenaers, Fernand Fontaine, Denis Franchimont, Olivier Dewit, Philippe Van Hootegem, Stijn Vanden Branden, Guy Lambrecht, Marc Ferrante
Background: Golimumab (GOL) is registered for moderate to severely active ulcerative colitis (UC). Data on the use of GOL in daily clinical practice are limited. Currently, it is unclear which factors are predictive of a favorable outcome. The goals of this study were to evaluate the mid-term outcome of GOL (week 26) in patients with moderate to severe UC and to determine predictors of favorable outcome. Methods: Patients included in the SMART study (NCT02155335) were evaluated for their mid-term outcome...
June 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29920382/identification-of-tumor-necrosis-factor-receptor-associated-factor-6-in-the-pearl-mussel-hyriopsis-cumingii-and-its-involvement-in-innate-immunity-and-pearl-sac-formation
#18
Dandan Huang, Zhiyi Bai, Jiexuan Shen, Liting Zhao, Jiale Li
Tumor necrosis factor receptor-associated factor 6 (TRAF6) acts as a central intracellular signal adapter molecule that mediates the tumor necrosis factor receptor superfamily and the interleukin-1 receptor/Toll-like receptor family in vertebrates and invertebrates. In the present study, HcTRAF6, a molluscan homologue of TRAF6 from Hyriopsis cumingii, has been cloned and identified. The entire open reading frame of HcTRAF6 was found to comprise a 1965-bp region that encodes a predicted protein of 654 amino acids, which contains conserved characteristic domains including a RING domain, two TRAF-type zinc finger domains, a typical coiled coil and the MATH domain...
June 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29920284/an-in-vitro-test-system-for-compounds-that-modulate-human-inflammatory-macrophage-polarization
#19
Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Nadja Wallner, Gerd Geisslinger, Andreas Weigert, Michael J Parnham
Macrophages undergo activation by pathophysiological stimuli to pro-inflammatory and bactericidal, or wound-healing and anti-inflammatory phenotypes, termed M1 or M2, respectively. Dysregulation of the M1-M2 balance is often associated with inflammatory diseases. Therefore, mechanisms of macrophage polarization may reveal new drug targets. We profiled six compounds with claimed modulatory effects on macrophage polarization using peripheral blood monocyte-derived macrophages. Based on the distinct mRNA or protein expression in macrophages stimulated either with M1 [lipopolysaccharide (LPS) + interferon-γ, IFNγ] or M2 interleukin-4 (IL-4) stimuli, we selected a combination of M1 (IL1β, tumor necrosis factor-α,TNFα, CC chemokine receptor 7, CCR7 and CD80) and M2 (chemokine (C-C motif) ligand 22, CCL22, CD200R and mannose receptor C type 1, MRC1) markers to monitor drug effects on "M1 polarization" or cells "pre-polarized to M1"...
June 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29920283/rutin-a-quercetin-glycoside-alleviates-acute-endotoxemic-kidney-injury-in-c57bl-6-mice-via-suppression-of-inflammation-and-up-regulation-of-antioxidants-and-sirt1
#20
Mohammad-Reza Khajevand-Khazaei, Parvaneh Mohseni-Moghaddam, Marjan Hosseini, Leila Gholami, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Acute kidney injury (AKI) is a common complication following severe sepsis, its incidence is increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a glycoside of the bioflavonoid quercetin with various protective effects due to its antioxidant and anti-inflammatory potential. In this research, we tried to assess the protective effect of rutin administration in a model of AKI in C57BL/6 mice. For induction of AKI, lipopolysaccharide (LPS) was injected once (10mg/kg, i.p.) and rutin was p...
June 16, 2018: European Journal of Pharmacology
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