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anti tumor necrosis factor

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https://www.readbyqxmd.com/read/29668128/tuberculosis-associated-with-tumor-necrosis-factor-%C3%AE-antagonists-case-description-and-analysis-of-reported-cases-in-colombia
#1
Leandro Galvis, Ángel Y Sánchez, Leonardo F Jurado, Martha I Murcia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667945/pulmonary-sarcoidosis-induced-by-anti-tumor-necrosis-factor-therapy-a-paradoxical-effect
#2
Alisson Aliel Vigano Pugliesi, Rachel Zerbini Mariano, Camila Matsunaga De Angelis, Manoel Barros Bertolo, Michel Alexandre Yazbek
No abstract text is available yet for this article.
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29667667/%C3%AE-cyperone-inhibits-lps-induced-inflammation-in-bv-2-cells-through-activation-of-akt-nrf2-ho-1-and-suppression-of-the-nf-%C3%AE%C2%BAb-pathway
#3
Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu, Juxiong Liu
Accumulating evidence has shown that activated microglia cause inflammatory immune response, which could lead to neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. α-Cyperone, one of the main ingredients of Cyperus rotundus oil, has been reported to possess anti-inflammatory activity in activated macrophages. In this study, we found that α-cyperone markedly decreased the production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in LPS-induced BV-2 cells...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29667146/cost-effectiveness-analysis-of-crohn-s-disease-treatment-with-vedolizumab-and-ustekinumab-after-failure-of-tumor-necrosis-factor-%C3%AE-antagonist
#4
Przemysław Holko, Paweł Kawalec, Andrzej Pilc
OBJECTIVE: The aim was to evaluate the cost-effectiveness of Crohn's disease (CD) treatment with vedolizumab and ustekinumab after failure of therapy with tumor necrosis factor-α antagonists (anti-TNFs). METHODS: The Markov model incorporated the lifetime horizon, synthesis-based estimates of biologics' efficacy in relation to anti-TNF exposure, and administration of biologics reflecting clinical practice (e.g., sequence of biologics, retreatment, 12-month treatment)...
April 17, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29664147/predictors-and-clinical-outcomes-of-follow-up-loss-in-patients-with-inflammatory-bowel-disease
#5
Dae Hyung Woo, Kyeong Ok Kim, Min Kyu Kang, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
BACKGROUND AND AIM: Nonadherence is a risk factor of disease worsening in inflammatory bowel disease (IBD). We analyzed the frequency, predictors, and clinical outcomes of patients with IBD who are lost to follow-up in outpatient clinics. METHODS: Medical records of 784 IBD patients visiting our IBD clinic between January 2010 and December 2015 were reviewed retrospectively. Overall, 285 newly diagnosed IBD patients who were followed up for at least 12 months were included in the analysis...
April 17, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29663644/biomimetic-sulfated-polyethylene-glycol-hydrogel-inhibits-proteoglycan-loss-and-tumor-necrosis-factor-%C3%AE-induced-expression-pattern-in-an-osteoarthritis-in-vitro-model
#6
Shabnam Hemmati-Sadeghi, Pradip Dey, Jochen Ringe, Rainer Haag, Michael Sittinger, Tilo Dehne
This study aimed to evaluate the potential of an anti-inflammatory polyethylene glycol (PEG) hydrogel for osteoarthritis (OA) management in an OA in vitro model. Freshly isolated porcine chondrocytes were maintained in high-density cultures to form cartilage-like three-dimensional micromasses. Recombinant porcine tumor necrosis factor-alpha (TNF-α) was used to induce OA-like changes. Normal and OA-like micromasses were treated with dendritic polyglycerol sulfate-based PEG hydrogel. Live/dead staining showed that all micromasses remained vital and presented similar morphological characteristics...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29663266/hepatitis-b-virus-screening-and-reactivation-in-a-national-va-cohort-of-patients-with-inflammatory-bowel-disease-treated-with-tumor-necrosis-factor-antagonists
#7
Rajesh Shah, Edith Y Ho, Jennifer R Kramer, Peter Richardson, Shubhada Sansgiry, Hashem B El-Serag, Jason K Hou
BACKGROUND: Practice guidelines recommend screening for hepatitis B virus (HBV) infection prior to initiating treatment of inflammatory bowel disease (IBD) with anti-tumor necrosis factor (anti-TNF) therapy. However, the adherence to these screening guidelines and the clinical outcomes of HBV reactivation following anti-TNF use are not well known. METHODS: This is a retrospective cohort study using the Veterans Health Administration datasets for IBD patients with filled prescriptions for anti-TNFs from 2003 to 2011...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29663159/evaluation-of-the-effect-of-polyphenol-of-escin-compared-with-ibuprofen-and-dexamethasone-in-synoviocyte-model-for-osteoarthritis-an-in-vitro-study
#8
Hossein Maghsoudi, Jamal Hallajzadeh, Mozhghan Rezaeipour
Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms. Today, drugs such as glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSIADs) are commonly employed for treatment of osteoarthritis, but have serious and life-threatening side effects. The aim of the current study is to evaluate the effects of escin on cyclooxygenase-2 (COX-2, isoform), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-18 (IL-18), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) (1), as well as prostaglandin E2 (PGE2) on inflammatory cells, similar osteoarthritis in synoviocytes, and monocytes/macrophages, and to compare it with dexamethasone (DEX) and ibuprofen (IBP)...
April 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29662931/ulcerative-colitis-are-we-neglecting-its-progressive-character
#9
Paulo Massinha, Francisco Portela, Sara Campos, Gabriela Duque, Manuela Ferreira, Sofia Mendes, Ana Margarida Ferreira, Carlos Sofia, Luís Tomé
Introduction: Ulcerative colitis (UC) is a chronic disease but its progressive character, with structural damage, is insufficiently studied. Objectives: To analyze a group of patients without referral bias, regarding its clinical course, the morphological damage, and functional status. Methods: We evaluated UC patients diagnosed between January 1, 2000 and December 31, 2004, living in the direct referral area of the hospital and determined the medication use, colectomy rate, structural damage ("lead pipe," stenosis, pseudopolyps, fibrous bridges), and anorectal function (prospective evaluation with the Cleveland Clinic Incontinence Score [CCIS] and the Fecal Incontinence Quality of Life Scale)...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29662851/anti-colitic-effect-of-purple-carrot-on-dextran-sulfate-sodium-dss-induced-colitis-in-c57bl-6j-mice
#10
Yeung-Ju Kim, Jaehyun Ju, Jia-Le Song, Suk-Geun Yang, Kun-Young Park
The anti-colitic effect of purple carrot (PC) on 2% dextran sulfate sodium (DSS)-induced colitis in C57BL6/J mice was compared with those of yellow carrot (YC), beet (BT), and red cabbage (RC). Component analysis showed that PC contained cyanidin-3-xyloglucoside, cyanidin-3-xylosyl(sinapoly-glucosyl)galactoside, cyanidin-3-xylosyl(feruloylglucosyl) galactoside, and cyanidin-3- O -(6- O -glycosyl-2- O -xylosylgalactoside). PC diet (5% in AIN 93G diet) strongly reduced DSS-induced colon shortening and inflammatory cell infiltration in mice, followed by RC, BT, and YC diets...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29662809/validation-of-nafamostat-mesilate-as-an-anticoagulant-in-extracorporeal-membrane-oxygenation-a-large-animal-experiment
#11
Sung Joon Han, Woosik Han, Hee-Jung Song, Cuk-Seong Kim, Seong-Mok Jeong, Min Woong Kang
Background: Unfractionated heparin is commonly used for anticoagulation in extracorporeal membrane oxygenation (ECMO). Several studies have shown that nafamostat mesilate (NM) has comparable clinical outcomes to unfractionated heparin. This study compared anticoagulation with NM and heparin in a large-animal model. Methods: Beagle dogs (n=8; weight, 6.5-9 kg) were placed on venovenous ECMO. Blood samples were taken every hour and the following parameters were compared: hemoglobin level, activated partial thromboplastin time (aPTT), thromboelastography (TEG) data, platelet function, and inflammatory cytokine levels...
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29662489/immunological-approaches-towards-cancer-and-inflammation-a-cross-talk
#12
REVIEW
Xinglong Qu, Ying Tang, Shucheng Hua
The inflammation is the protective response of the body against various harmful stimuli; however, the aberrant and inappropriate activation tends to become harmful. The acute inflammatory response tends to resolved once the offending agent is subside but this acute response becomes chronic in nature when the body is unable to successfully neutralized the noxious stimuli. This chronic inflammatory microenvironment is associated with the release of various pro-inflammatory and oncogenic mediators such as nitric oxide (NO), cytokines [IL-1β, IL-2, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)], growth factor, and chemokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29662312/nanoselenium-prevents-eimeriosis-induced-inflammation-and-regulates-mucin-gene-expression-in-mice-jejunum
#13
Abdulsalam A Alkhudhayri, Mohamed A Dkhil, Saleh Al-Quraishy
Background: Although elemental selenium has been found to be effective against Eimeria , no study has yet investigated the effects of selenium nanoparticles (SeNPs) on the Eimeria parasite. The aim of this study, therefore, was to evaluate the ameliorative effect of SeNPs compared with elemental selenium on mice jejunum infected with sporulated oocysts of Eimeria papillata . Methods: The mice were divided into 4 groups, with the first being the non-infected, control group, and the second, third, and fourth groups being orally inoculated with 1,000 sporulated oocysts of E...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29661292/etanercept-restores-vasocontractile-sensitivity-affected-by-mesenteric-ischemia-reperfusion
#14
S Erpulat Ozis, Tamila Akhayeva, Sahika Guner, Sibel S Kilicoglu, Arzu Pampal
BACKGROUND: The aim of the study is to evaluate in vivo and in vitro effects of etanercept, a soluble tumor necrosis factor receptor, on the contractile responses of superior mesenteric artery in an experimental mesenteric ischemia and reperfusion model. MATERIAL AND METHODS: After obtaining animal ethics committee approval, 24 Sprague-Dawley rats were allocated to three groups. Control group (Gr C, n = 6) underwent a sham operation, whereas ischemia/reperfusion and treatment groups underwent 90 min ischemia and 24-h reperfusion (Gr I/R, n = 12; Gr I/R+E, n = 6)...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29661087/allylpyrocatechol-attenuates-methotrexate-induced-hepatotoxicity-in-a-collagen-induced-model-of-arthritis
#15
Soumita De, Sunanda Kundu, Uttara Chatterjee, Subrata Chattopadhyay, Mitali Chatterjee
The cornerstone of treatment for rheumatoid arthritis is low dose methotrexate (MTX), but its use is limited by concerns regarding its potential for hepatotoxicity. Allylpyrocatechol (APC), a phytoconstituent sourced from leaves of Piper betle demonstrated antioxidant, anti-inflammatory and antiarthritic properties. The present study aimed to evaluate the combined effect of APC and MTX on limiting progression of lipopolysaccharide accelerated collagen-induced arthritis, along with reduction of MTX-induced hepatic damage...
April 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#16
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
April 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29660509/glycosylation-enhanced-biocompatibility-of-the-supramolecular-hydrogel-of-an-anti-inflammatory-drug-for-topical-suppression-of-inflammation
#17
Taotao Xiong, Xianglian Li, Yanfang Zhou, Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
Intravitreal/periocular injection of triamcinolone acetonide (TA) suspension is a common uveitis treatment, but it displays a high risk for serious side effects (e.g., high intraocular pressure, retinal toxicity). We report here an intravitreally injectable thermosensitive glycosylated TA (TA-SA-Glu) hydrogel, formed by covalently conjugating glucosamine (Glu) with succinate TA (TA-SA), for treating uveitis. The TA-SA-Glu hydrogelator forms a supramolecular hydrogel spontaneously in aqueous solution with a minimal gelation concentration of 0...
April 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29660467/investigation-of-constituents-from-cinnamomum-camphora-l-j-presl-and-evaluation-of-their-anti-inflammatory-properties-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#18
Yan-Ru Li, Chun-Sheng Fu, Wen-Jing Yang, Xiao-Ling Wang, Dan Feng, Xiao-Ning Wang, Dong-Mei Ren, Hong-Xiang Lou, Tao Shen
ETHNOPHARMACOLOGY RELEVANCE: Cinnamomum camphora (L.) J. Presl has been used for the traditional medicine as a therapeutic agent of inflammation-related diseases, including sprains, rheumatic arthritis, abdominal pain, cough and bronchitis, for a long history. The aim of the present study was to illustrate anti-inflammatory substances of C. camphora and their mechanism of action, and to establish the correlations between chemical constituents and traditional uses of this plant. MATERIALS AND METHODS: Chemical constituents were purified by chromatographic methods, and their structures were established based on spectroscopic analysis...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29660465/jageum-jung-improves-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-mice-and-suppresses-pro-inflammatory-chemokine-production-by-inhibiting-tnf-%C3%AE-ifn-%C3%AE-induced-stat-1-and-nf%C3%AE%C2%BAb-signaling-in-hacat-cells
#19
Ju-Hye Yang, Hyun Ju Do, Esther Lee, Nam-Hui Yim, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Jageum-Jung (JGJ) is an oriental herbal formula comprising five herbs (Melaphis chinensis Bell, Cremastra variabilis Nakai, Knoxia valerianoides Thorel, Euphorbia lathyris L., and Moschus moschiferus L.). It has been used for detoxification and treating cancer and inflammatory diseases in China, Japan, and Korea. However, the mechanism of action of JGJ on keratinocyte inflammatory response is poorly understood. AIM OF THE STUDY: In the present study, we investigated the anti-inflammatory mechanism of JGJ and studied the effects of JGJ on atopic dermatitis-like skin lesions in mice...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29660425/certolizumab-pegol-for-the-treatment-of-chronic-plaque-psoriasis-results-through-48-weeks-of-a-phase-3-multicenter-randomized-double-blinded-etanercept-and-placebo-controlled-study-cimpact
#20
Mark Lebwohl, Andrew Blauvelt, Carle Paul, Howard Sofen, Jolanta Węgłowska, Vincent Piguet, Daniel Burge, Robert Rolleri, Janice Drew, Luke Peterson, Matthias Augustin
BACKGROUND: Phase 2 psoriasis studies with the Fc-free, PEGylated, anti-tumor necrosis factor biologic certolizumab pegol demonstrated meaningful clinical activity. OBJECTIVE: Assess safety and efficacy of certolizumab in adults with moderate-to-severe chronic plaque psoriasis. METHODS: Patients were randomized 3:3:1:3 to certolizumab 400 mg, 200 mg, or placebo every 2 weeks for 16 weeks or etanercept 50 mg twice-weekly for 12 weeks. Certolizumab-treated patients achieving ≥75% reduction in psoriasis area and severity index at Week 16 were re-randomized to certolizumab or placebo for 32 weeks...
April 13, 2018: Journal of the American Academy of Dermatology
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