keyword
MENU ▼
Read by QxMD icon Read
search

Chind

keyword
https://www.readbyqxmd.com/read/27775440/assessment-of-genotoxicity-in-female-agricultural-workers-exposed-to-pesticides
#1
Rekhadevi P V, M F Rahman, M Mahboob, S I Kumari, S Chinde, Bhanuramya M, Naresh D, Paramjit Grover
OBJECTIVE: This study was designed to determine the genotoxic effect of exposure to a mixture of pesticides in 106 female agricultural workers employed in cotton fields from India. METHODS: Comet, micronucleus and chromosomal aberrations tests were carried out in peripheral blood lymphocytes. Micronucleus test was also performed in buccal epithelial cells. Levels of antioxidant enzymes, RBC Acetylcholinesterase and hematological parameters were analyzed in the blood samples of the study subjects...
October 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27396180/-extreme-climatic-events-in-the-altai-republic-according-to-dendrochronological-data
#2
V V Barinov, V S Myglan, A N Nazarov, E A Vaganov, A R Agatova, R K Nepop
The results of dating of extreme climatic events by damage to the anatomical structure and missing tree rings of the Siberian larch in the upper forest boundary of the Altai Republic are given. An analysis of the spatial distribution of the revealed dates over seven plots (Kokcy, Chind, Ak-ha, Jelo, Tute, Tara, and Sukor) allowed us to distinguish the extreme events on interregional (1700, 1783, 1788, 1812, 1814, 1884), regional (1724, 1775, 1784, 1835, 1840, 1847, 1850, 1852, 1854, 1869, 1871, 1910, 1917, 1927, 1938, 1958, 1961), and local (1702, 1736, 1751, 1785, 1842, 1843,1874, 1885, 1886, 1919, 2007, and 2009) scales...
March 2016: Izvestiia Akademii Nauk. Seriia Biologicheskaia
https://www.readbyqxmd.com/read/27036521/iodine-catalyzed-simple-and-efficient-synthesis-of-antiproliferative-2-pyridones
#3
Komuraiah Buduma, Srinivas Chinde, Niranjana Kumar Arigari, Paramjit Grover, K V N S Srinivas, J Kotesh Kumar
A simple and efficient method for the selective synthesis of 2-pyrdones from 4H-pyrans using iodine as catalyst and ethanol as solvent was developed. The present method is equally effective for both aromatic and hetero aromatic ring containing 4H-pyrans. The compatibility with various functional groups, mild reaction conditions, high yields and application of inexpensive, readily and easily available iodine as catalyst and formation of 2-pyridones as major products are the advantages of the present procedure...
May 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/26873414/synthesis-and-evaluation-of-anticancer-and-antiobesity-activity-of-1-ethoxy-carbonyl-3-5-bis-3-indolyl-methylene-4-pyperidone-analogs
#4
Komuraiah Buduma, Srinivas Chinde, Anand Kumar Dommati, Pooja Sharma, Aparna Shukla, K V N Satya Srinivas, Niranjana Kumar Arigari, Feroz Khan, Ashok Kumar Tiwari, Paramjit Grover, Kotesh Kumar Jonnala
A series of eleven novel bisindole derivatives were synthesized and screened for anticancer and antiobesity potentials in in vitro mode. The reaction of 1-ethoxy carbonyl 4-pyperidone 1a with indole-3-carboxaldehyde 1b in presence of catalytic amount of piperidine gave 2 which was N-alkylated with different benzyl halides in the presence of potassium carbonate to afford compounds 3a-3k in quantitative yields. Among the compounds tested for anticancer activity against different human cancer cell lines, 3f significantly inhibited HepG2 cell line (IC50 7...
March 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/26503004/genotoxic-effects-of-chromium-oxide-nanoparticles-and-microparticles-in-wistar-rats-after-28-days-of-repeated-oral-exposure
#5
Shailendra Pratap Singh, Srinivas Chinde, Sarika Srinivas Kalyan Kamal, M F Rahman, M Mahboob, Paramjit Grover
The nanotechnology industry has advanced rapidly in the last 10 years giving rise to the growth of the nanoparticles (NPs) with great potential in various arenas. However, the same properties that make NPs interesting raise concerns because their toxicity has not been explored. The in vivo toxicology of chromium oxide (Cr2O3)-NPs is not known till date. Therefore, this study investigated the 28-day repeated toxicity after 30, 300 and 1000 mg/kg body weight (bw)/day oral treatment with Cr2O3-NPs and Cr2O3 microparticles (MPs) in Wistar rats...
February 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/25743216/synthesis-docking-and-admet-studies-of-novel-chalcone-triazoles-for-anti-cancer-and-anti-diabetic-activity
#6
Yakaiah Chinthala, Sneha Thakur, Shalini Tirunagari, Srinivas Chinde, Anand Kumar Domatti, Niranjana Kumar Arigari, Srinivas K V N S, Sarfaraz Alam, Kotesh Kumar Jonnala, Feroz Khan, Ashok Tiwari, Paramjit Grover
A series of novel chalcone-triazole derivatives were synthesized and screened for in vitro anticancer activity on the human cancer cell lines IMR32 (neuroblastoma), HepG2 (hepatoma) and MCF-7 (breast adenocarcinoma), DU-145 (prostate carcinoma), and A549 (lung adenocarcinoma). Among the tested compounds, 4r showed the most promising anticancer activity in all the cell lines whereas, compounds 4c (IC50 65.86 μM), 4e (IC50 66.28 μM), 4o (IC50 35.81 μM), 4q (IC50 50.82 μM) and 4s (IC50 48.63 μM) showed better activity than the standard doxorubicin (IC50 69...
March 26, 2015: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/25329169/antiretroviral-therapy-program-expansion-in-zamb%C3%A3-zia-province-mozambique-geospatial-mapping-of-community-based-and-health-facility-data-for-integrated-health-planning
#7
Troy D Moon, Ezequiel B Ossemane, Ann F Green, Elisée Ndatimana, Eurico José, Charlotte P Buehler, C William Wester, Sten H Vermund, Omo Olupona
OBJECTIVE: To generate maps reflecting the intersection of community-based Voluntary Counseling and Testing (VCT) delivery points with facility-based HIV program demographic information collected at the district level in three districts (Ile, Maganja da Costa and Chinde) of Zambézia Province, Mozambique; in order to guide planning decisions about antiretroviral therapy (ART) program expansion. METHODS: Program information was harvested from two separate open source databases maintained for community-based VCT and facility-based HIV care and treatment monitoring from October 2011 to September 2012...
2014: PloS One
https://www.readbyqxmd.com/read/25276067/anticancer-active-homoisoflavone-from-the-underground-bulbs-of-ledebouria-hyderabadensis
#8
Yakaiah Chinthala, Srinivas Chinde, Arigari Niranjana Kumar, K V N Satya Srinivas, Jonnala Kotesh Kumar, Kakaraparthy Pandu Sastry, Paramjit Grover, M Venkat Ramana
BACKGROUND: Ledebouria is a genus of deciduous or weakly evergreen bulbs in the Hyacinthaceae family. This is recognized as the first collection made of the new taxon Ledebouria hyderabadensis, exist in the Hyderabad city of Andhra Pradesh, India. OBJECTIVE: The goal of this work was to investigate the phytochemical constituents present in the new specifies and also to evaluate the cytotoxic properties of the extracts and pure compounds against human cancer cell lines...
October 2014: Pharmacognosy Research
https://www.readbyqxmd.com/read/24906834/assessment-of-genotoxic-effects-of-lead-in-occupationally-exposed-workers
#9
Srinivas Chinde, Monika Kumari, Kanapuram Rudrama Devi, Upadhyayula Suryanarayana Murty, Mohammed Fazlur Rahman, Srinivas Indu Kumari, Mohammed Mahboob, Paramjit Grover
The genotoxicological effects in 200 lead acid storage battery recycling and manufacturing industry workers in Hyderabad along with matched 200 controls were studied. The genetic damage was determined by comet, micronucleus (MN), and chromosomal aberration (CA) test in peripheral blood lymphocytes (PBL). The MN test was also carried out in buccal epithelial cells (BECs). Pb in ambient air, blood Pb (B-Pb) concentrations, and hematological parameters were measured. The superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and malondialdehyde (MDA) formed were also studied...
October 2014: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/24863917/fabrication-characterization-and-bioevaluation-of-silibinin-loaded-chitosan-nanoparticles
#10
Deep Pooja, Dileep J Babu Bikkina, Hitesh Kulhari, Nalla Nikhila, Srinivas Chinde, Y M Raghavendra, B Sreedhar, Ashok K Tiwari
Silibinin is reported to possess multiple biological activities. However, its hydrophobic nature limits its bioavailability compromising in vivo biological activities. Nanoparticles-based delivery of such molecules has emerged as new technique to resolve these issues. Bio-degradable, compatible and adhesive nature of chitosan has recently attracted its suitability as a carrier for biologically active molecules. This study presents fabrication and characterization of chitosan-tripolyphosphate based encapsulation of silibinin...
August 2014: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/24510415/toxicity-study-of-cerium-oxide-nanoparticles-in-human-neuroblastoma-cells
#11
Monika Kumari, Shailendra Pratap Singh, Srinivas Chinde, Mohammed Fazlur Rahman, Mohammed Mahboob, Paramjit Grover
The present study consisted of cytotoxic, genotoxic, and oxidative stress responses of human neuroblastoma cell line (IMR32) following exposure to different doses of cerium oxide nanoparticles (CeO2 NPs; nanoceria) and its microparticles (MPs) for 24 hours. Cytotoxicity was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase assays whereas genotoxicity was assessed using the cytokinesis-block micronucleus and comet assays. A battery of assays including lipid peroxidation, reactive oxygen species (ROS), hydrogen peroxide, reduced glutathione, nitric oxide, glutathione reductase, glutathione peroxidase, superoxide dismutase, catalase, and glutathione S-transferase were performed to test the hypothesis that ROS was responsible for the toxicity of nanoceria...
March 2014: International Journal of Toxicology
https://www.readbyqxmd.com/read/20645964/the-difference-of-heart-rate-recovery-between-males-with-and-without-erectile-dysfunction
#12
M Tolga Dogru, M Murad Basar, Ahmet Haciislamoglu
AIM: In this study, we aimed to investigate the relationship between heart rate recovery (HRR) time and Chronotropic Index (CHIND) parameters, which also reflect autonomic function, after exercise stress test (EST) in males with or without erectile dysfunction (ED), and we investigated the relationship between HRR and CHIND and serum steroid hormone levels. MATERIAL AND METHODS: A total of 135 participants (mean age: 45.0 +/- 11.8 years) were enrolled into the study...
July 2010: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/20104904/a-novel-non-natural-nucleoside-that-influences-p-glycoprotein-activity-and-mediates-drug-resistance
#13
Kevin T Eng, Anthony J Berdis
Multidrug resistance during cancer chemotherapy is commonly acquired by overexpression of the ATP binding cassette transporter, P-glycoprotein (P-gp). As such, inhibitors that target P-gp activity represent potential therapeutic agents against this form of drug resistance. This study evaluated the ability of various non-natural nucleosides that mimic the core structure of adenosine to modulate drug resistance by inhibiting the ATPase activity to P-gp. Of several analogues tested, only one novel non-natural nucleoside, 5-cyclohexylindolyl-2'-deoxyribose (5-CHInd), behaves as a P-gp inhibitor...
March 2, 2010: Biochemistry
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"