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gynaecology oncology

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https://www.readbyqxmd.com/read/27909879/investigating-vaginal-bleeding-in-postmenopausal-women-found-to-have-an-endometrial-thickness-of-equal-to-or-greater-than-10%C3%A2-mm-on-ultrasonography
#1
Hilary L Turnbull, Nikolaos Akrivos, Paul Simpson, Timothy J Duncan, Joaquin J Nieto, Nikolaos Burbos
PURPOSE: This aim of this study is to determine the risk of endometrial cancer in symptomatic postmenopausal women, when endometrial thickness on transvaginal ultrasonography is equal to or greater than 10 mm, and subsequent office-based endometrial sampling histology is negative. METHODS: This is a prospective cross-sectional study, performed in a gynaecological oncology centre in the United Kingdom between February 2008 and July 2012. All postmenopausal women presenting with vaginal bleeding were investigated using transvaginal ultrasonography...
December 1, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27888704/association-of-r156r-single-nucleotide-polymorphism-of-the-ercc2-gene-with-the-susceptibility-to-ovarian-cancer
#2
Hanna Romanowicz, Magdalena M Michalska, Dariusz Samulak, Jakub Malinowski, Tomasz Szaflik, Jan Bieńkiewicz, Beata Smolarz
AIM: The reported study was designed to explore associations between the ERCC2- R156R gene single nucleotide polymorphism (SNP) and the risk of ovarian cancer. MATERIAL AND METHODS: The R156R (C to A, rs238406) polymorphism of ERCC2 gene was investigated by the PCR-RFLP technique in 400 patients with ovarian carcinoma and 400 age- and sex matched non-cancer controls. Blood samples were obtained from patients treated at the Department of Surgical Gynaecology and Gynaecologic Oncology, Institute of Polish Mothers Memorial Hospital between the years 2000 and 2015...
November 15, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27843621/does-clinical-trial-participation-improve-outcomes-in-patients-with-ovarian-cancer
#3
L Khoja, L Horsley, A Heesters, J D Machin, C Mitchell, A R Clamp, G C Jayson, J Hasan
INTRODUCTION: Treatment on a clinical trial is considered to be beneficial to oncology patients. However, supportive evidence for this is scarce. Trial effect describes the phenomenon of improved health outcomes in patients treated with standard of care (SOC) on trial compared to those receiving SOC outside of a clinical trial. We evaluated trial effect in patients with ovarian cancer treated at our tertiary cancer centre. METHODS: We performed a retrospective cohort study of patients with ovarian cancer treated at The Christie National Health Service Foundation Trust...
2016: ESMO Open
https://www.readbyqxmd.com/read/27816539/feasibility-study-of-toxicity-outcomes-using-gec-estro-contouring-guidelines-on-ct-based-instead-of-mri-based-planning-in-locally-advanced-cervical-cancer-patients
#4
Vicky Koh, Bok Ai Choo, Khai Mun Lee, Teng Hwee Tan, Jen Hui Jeffrey Low, Soon Yau Joseph Ng, Arunachalam Ilancheran, Liang Shen, Johann Tang
PURPOSE: To report late rectal and bladder toxicity outcomes of a CT-based image-guided brachytherapy (IGBT) technique for treatment of cervical cancer. METHODS AND MATERIALS: Between 2008 and 2014, 95 women with International Federation of Gynecology and Obstetrics stage IB to IVA cervical carcinoma treated with definitive concurrent cisplatin-based chemotherapy and external beam radiation therapy 50.4 Gy in 28 fractions followed by planned prescription dose of 7 Gy × 4 fractions of high-dose-rate IGBT was retrospectively reviewed...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27806031/gynaecological-cancer-pathway-for-faster-cancer-treatment-a-clinical-audit
#5
Catherine Askew, Anand Gangji
: Gynaecological cancers make up 10% of cancer cases and 10% of female cancer deaths in New Zealand. The services for investigation and treatment of these women are regionally specific rather than centrally organised; hence we need appropriate standards of service and clear pathways for communication and management of these patients to ensure consistent care that is in line with the Ministry of Health goals for faster cancer treatment. AIM: The aim of this audit is to ensure faster gynaecological cancer management pathways for Northland patients...
October 28, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27769260/submucous-uterine-adenosarcoma-minimally-invasive-treatment
#6
H Krentel, R L De Wilde
BACKGROUND: Uterine adenosarcomas are rare malignant gynaecological tumours. Due to its submucous localization, they can be easily confound with benign tumours like endometrial polyps or submucous myomas. However, the treatment of uterine adenosarcomas requires an oncologic surgical approach. CASE PRESENTATION: In the following case report, we present the minimally invasive treatment of a uterine adenosarcoma by hysteroscopy and laparoscopy in a 37-year-old patient and discuss the special role of hysteroscopy in such cases...
October 21, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27761279/predictive-and-prognostic-factors-in-ovarian-and-uterine-carcinosarcomas
#7
İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdogan, M Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç
BACKGROUND: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT...
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27687308/impact-of-early-palliative-care-on-caregivers-of-patients-with-advanced-cancer-cluster-randomised-trial
#8
J McDonald, N Swami, B Hannon, C Lo, A Pope, A Oza, N Leighl, M Krzyzanowska, G Rodin, L W Le, C Zimmermann
BACKGROUND: Early palliative care improves the quality of life (QOL) and satisfaction with care of patients with advanced cancer, but little is known about its effect on caregivers. Here we report outcomes of caregiver satisfaction with care and QOL from a trial of early palliative care. PATIENT AND METHODS: Twenty-four medical oncology clinics were cluster-randomised, stratified by tumour site (lung, gastrointestinal, genitourinary, breast, gynaecological), to early palliative care team referral, or to standard oncology care with palliative care only as needed...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27664393/improving-outcomes-for-older-women-with-gynaecological-malignancies
#9
REVIEW
Lucy Dumas, Alistair Ring, John Butler, Tania Kalsi, Danielle Harari, Susana Banerjee
The incidence of most gynaecological malignancies rises significantly with increasing age. With an ageing population, the proportion of women over the age of 65 with cancer is expected to rise substantially over the next decade. Unfortunately, survival outcomes are much poorer in older patients and evidence suggests that older women with gynaecological cancers are less likely to receive current standard of care treatment options. Despite this, older women are under-represented in practice changing clinical studies...
August 29, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27651643/the-role-of-completion-surgery-in-ovarian-cancer
#10
Thomas Vinotha, Thomas Anitha, Sebastian Ajit, Chandy Rachel, Peedicayil Abraham
INTRODUCTION: Patients referred with inadequately staged ovarian malignancies present a clinical dilemma. We report our experience with completion surgery in ovarian cancer. AIMS AND OBJECTIVES: To determine the benefits and risks of completion surgery in women with ovarian cancer who presented after having had inadequate primary surgery. METHODS: A retrospective case series of 30 women with ovarian cancer and one with fallopian tube cancer who had inadequate primary surgery underwent completion surgery at gynaecologic oncology unit in a tertiary level hospital in Tamil Nadu, India...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27648648/european-society-of-gynaecologic-oncology-quality-indicators-for-advanced-ovarian-cancer-surgery
#11
Denis Querleu, François Planchamp, Luis Chiva, Christina Fotopoulou, Desmond Barton, David Cibula, Giovanni Aletti, Silvestro Carinelli, Carien Creutzberg, Ben Davidson, Philip Harter, Lene Lundvall, Christian Marth, Philippe Morice, Arash Rafii, Isabelle Ray-Coquard, Andrea Rockall, Cristiana Sessa, Ate van der Zee, Ignace Vergote, Andreas du Bois
OBJECTIVES: The surgical management of advanced ovarian cancer involves complex surgery. Implementation of a quality management program has a major impact on survival. The goal of this work was to develop a list of quality indicators (QIs) for advanced ovarian cancer surgery that can be used to audit and improve the clinical practice. This task has been carried out under the auspices of the European Society of Gynaecologic Oncology (ESGO). METHODS: Quality indicators were based on scientific evidence and/or expert consensus...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27609329/single-access-laparoscopic-approach-in-the-surgical-treatment-of-endometrial-cancer-a-single-institution-experience-and-review-of-literature
#12
Giacomo Corrado, Giuseppe Cutillo, Giulia Pomati, Emanuela Mancini, Ermelinda Baiocco, Lodovico Patrizi, Maria Saltari, Francesco Barletta, Fabiola Patani, Enrico Vizza
BACKGROUND: The aim of this study was to assess the surgical and oncological outcome for the management of endometrial cancer (EC) by laparoendoscopic single-site surgery (LESS). PATIENTS AND METHODS: We performed a retrospective chart review of patients who underwent a LESS for EC. All the patients were treated by the same surgical team between July 2009 and June 2013 at the Gynaecologic Oncologic Unit, Regina Elena National Cancer Institute, Rome, Italy. RESULTS: A total of 50 women were included, with a median age of 45 years (range, 39-84 years) and a median body mass index (BMI) of 21...
October 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27550405/carcinoma-of-the-cervix-in-elderly-patients-treated-with-radiotherapy-patterns-of-care-and-treatment-outcomes
#13
Ming Yin Lin, Srinivas Kondalsamy-Chennakesavan, David Bernshaw, Pearly Khaw, Kailash Narayan
OBJECTIVE: The aim of this analysis was to examine the management of cervix cancer in elderly patients referred for radiotherapy and the results of treatment in terms of overall survival (OS), relapse-free survival (RFS), and treatment-related toxicities. METHODS: Patients were eligible if they were aged ≥75 years, newly diagnosed with cervix cancer and referred for radiotherapy as part of their treatment. Patient details were retrieved from the gynaecology service database where clinical, histopathological treatment and follow-up data were prospectively collected...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27544133/the-laparoscopic-assisted-combined-hysterectomy-a-new-surgical-concept-compared-to-the-classical-laparoscopic-assisted-vaginal-hysterectomy-by-a-prospective-study
#14
Garri Tchartchian, Pamela Heldmann, Bernd Bojahr, Angelika Larbig, Rudy-Leon De Wilde
BACKGROUND AND AIMS: This controlled trial with II-1 evidence compared the safety and efficacy of the new laparoscopic-assisted combined hysterectomy (LACH) with the standard surgical technique laparoscopic-assisted vaginal hysterectomy (LAVH) in general and in patients displaying risk factors (large uterus, vaginal nulliparity, prior caesarean section). METHODS: From June 2007 to September 2008, 101 patients underwent a hysterectomy at the Clinic of Gynaecology, Obstetrics and Gynaecological Oncology at the Pius Hospital, University Hospital for Gynaecology in Oldenburg...
August 20, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27535757/preoperative-local-staging-of-endometrial-cancer-the-challenge-of-imaging-techniques-and-serum-biomarkers
#15
Roberto Angioli, Francesco Plotti, Stella Capriglione, Giuseppe Scaletta, Nella Dugo, Alessia Aloisi, Claudia Lucia Piccolo, Riccardo Del Vescovo, Corrado Terranova, Bruno Beomonte Zobel
OBJECTIVE: The aim of this study is to prospectively evaluate and compare the accuracy of high-frequency TVS and of two type of MRI (dynamic contrast-enhanced MRI or diffusion-weighted MRI), in association with HE4 in preoperative endometrial cancer (EC) staging. STUDY DESIGN: Starting from January 2012 to February 2015, all patients with EC at prior endometrial biopsy, referred to the Division of Gynaecologic Oncology of the University Campus Bio-Medico of Rome, were prospectively included in the study...
August 17, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27530527/changing-patterns-of-referrals-and-outcomes-of-genetic-participation-in-gynaecological-oncology-multidisciplinary-care
#16
Hanoon P Pokharel, Neville F Hacker, Lesley Andrews
BACKGROUND: Genetic participation in gynaecological oncology multidisciplinary team meetings (MDT) may identify the sentinel cancer in women with hereditary breast-ovarian cancer syndrome or Lynch syndrome. AIMS: To identify the changing patterns of genetic referral from 2010 to 2014 and the outcomes of referrals through clinical MDT case review. MATERIALS AND METHODS: Medical records of cases of gynaecological cancer presented at the MDT meetings and genetics databases were reviewed to determine the frequency and outcomes of recommendations for genetic referral between 2010 and 2014...
December 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27519974/transvaginal-ultrasound-tvus-guided-biopsy-is-safe-and-effective-in-diagnosing-peritoneal-carcinomatosis-and-recurrent-pelvic-malignancy
#17
G Dadayal, M Weston, A Young, J L Graham, K Mehta, N Wilkinson, J A Spencer
AIM: To assess safety and accuracy of transvaginal ultrasound (TVUS)-guided biopsy in achieving a diagnosis of peritoneal carcinomatosis (PC). MATERIALS AND METHODS: This was a retrospective study comprising a cohort of 54 consecutive women aged 18-85 years referred from the gynaecological oncology multidisciplinary team meeting (MDTM) who attended for TVUS-guided biopsy procedures in a tertiary oncology centre over a 4-year period (2010-2014). Clinicopathological validation was assessed using online patient records and radiological information systems...
November 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27484100/ct-in-ovarian-cancer-staging-how-to-review-and-report-with-emphasis-on-abdominal-and-pelvic-disease-for-surgical-planning
#18
REVIEW
Anju Sahdev
CT of the abdomen and pelvis is the first line imaging modality for staging, selecting treatment options and assessing disease response in ovarian cancer. The staging CT provides disease distribution, disease burden and is the imaging surrogate for surgico-pathological FIGO staging. Optimal cyto-reductive surgery offers patients' the best chance for disease control or cure, but sub-optimal resection confers no advantage over chemotherapy and adversely increases the risk of post surgical complications. Although there is extensive literature comparing performance of CT against laparoscopy and surgery, for the staging abdominal and pelvic CT, there are currently no accepted guidelines for interpretation or routinely used minimum data set templates for reporting these complex CT scans often with extensive radiological findings...
August 2, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27474485/-responsibility-for-the-loss-of-opportunity-in-malignant-cancer-care-in-the-spanish-public-healthcare-system
#19
Carlos Sardinero-García, Andrés Santiago-Sáez, M Del Carmen Bravo, Bernardo Perea-Pérez, M Elena Albarrán-Juan, Elena Labajo-González, Julián Benito-León
OBJECTIVE: The loss of chance in healthcare has been forcibly introduced in the adjudications pronounced in recent years. Our objective was to analyse the verdicts of guilt resulting from the loss of chance ordered by the Contentious-Administrative Court (i.e., in the public healthcare system), in which both the origin of the disease to be treated and the sequelae were oncological processes. METHOD: We analysed 137 cancer-related court judgments from the Contentious-Administrative Court, which referred to the concept of loss of chance, issued in Spain up to May 2014...
July 26, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27465892/long-term-pelvic-floor-function-and-quality-of-life-after-radical-surgery-for-cervical-cancer-a-multicenter-comparison-between-different-techniques-for-radical-hysterectomy-with-pelvic-lymphadenectomy
#20
Marloes Derks, Jacobus van der Velden, Minke M Frijstein, Willemijn M Vermeer, Anne M Stiggelbout, Jan Paul W R Roovers, Cornelis D de Kroon, Moniek M Ter Kuile, Gemma G Kenter
OBJECTIVE: This study aimed to compare urinary and bowel symptoms and quality of life (QoL) among women treated with a Wertheim-Meigs (WM, type III) or Wertheim-Okabayashi (WO, type IV) radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer. METHODS: In this cross-sectional observational study, patients treated with a WO or a (nerve sparing) WM radical hysterectomy (with or without adjuvant radiotherapy) between January 2000 and December 2010 in the Center for Gynaecological Oncology Amsterdam or Leiden University Medical Center were included...
October 2016: International Journal of Gynecological Cancer
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