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https://www.readbyqxmd.com/read/29140834/prognostic-factors-in-patients-with-metastatic-spinal-cord-compression-secondary-to-melanoma-a-systematic-review
#1
Nicholas J Hadden, Jerome R D McIntosh, Samuel Jay, Paula J Whittaker
Melanoma is one of the most common primary tumours associated with metastatic spinal cord compression (MSCC). The aim of this review is to identify prognostic factors specifically for MSCC secondary to melanoma. A systematic search of literature was performed in MEDLINE, Embase and the Cochrane Library to identify studies reporting prognostic factors for patients with MSCC secondary to melanoma. Two studies, involving a total of 39 patients, fulfilled the inclusion criteria. The variables associated with increased survival were receiving postoperative radiotherapy, receiving chemotherapy, perioperative lactate dehydrogenase level less than or equal to 8...
November 14, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29138883/hallmarks-of-bone-metastasis
#2
REVIEW
Rachelle W Johnson, Larry J Suva
Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for controlling tumor progression, with little or no emphasis on tumor eradication. Indeed, the clinical course of metastatic breast cancer is relatively long, with patients likely to experience sequential skeletal-related events (SREs), often over lengthy periods of time, even up to decades...
November 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29137014/radiological-manifestations-and-surgical-outcome-of-combined-upper-cervical-cord-compression-and-cervical-ossification-of-the-posterior-longitudinal-ligament-with-a-minimum-2-year-follow-up
#3
Hao Li, Xiaopeng Zhou, Gang Chen, Fangcai Li, Junfeng Zhu, Qixin Chen
Combined upper cervical cord compression associated with cervical ossification of the posterior longitudinal ligament (OPLL) is a rare and under-recognized disorder. The aim of this study was to investigate the radiological manifestations and surgical outcome of this combined disease.Between May 2011 and July 2015, patients who underwent surgery for combined upper cervical cord compression and cervical OPLL in our institution were included in this study. After a minimum 2-year follow-up, radiological and clinical data were collected...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136257/risk-factors-for-pathological-fracture-and-metastatic-epidural-spinal-cord-compression-in-patients-with-spinal-metastases
#4
Catherine S Hibberd, Gerald M Y Quan
Vertebral pathological fracture and metastatic epidural spinal cord compression (MESCC) due to metastatic cancer inevitably cause pain, neurological deficit, impaired function, and decreased quality of life and are indications for surgery. In such cases, earlier surgical intervention has the potential to prevent permanent neurological deficit and disability and to maintain function and quality of life. Therefore, the aim of this study was to identify and evaluate risk factors for pathological fracture and MESCC in patients with spinal metastases...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29135530/should-percussion-pacing-have-a-role-in-perioperative-advanced-cardiac-life-support-a-case-report
#5
Chris Giordano, Jordan Miller, Ilan Keidan
Percussion pacing involves using one's fist to repeatedly strike a patient's left sternal border in a rhythmic manner. The resulting increase in ventricular pressure can trigger myocardial depolarization and subsequent contraction. We describe the successful treatment of acute preoperative symptomatic sinus bradycardia with percussion pacing in a 63-year-old patient scheduled for placement of a gastric feeding tube after trauma involving spinal cord injury. Although no longer included in current advanced cardiovascular life support guidelines, percussion pacing may be a suitable alternative to chest compressions in multitrauma cases where the force of compressions could cause further complications...
November 9, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29131102/a-case-of-a-4-year-old-female-with-a-primary-spinal-malignancy-presenting-with-froin-s-syndrome
#6
Andrew T Hale, Gregory P Fricker, Travis W Crook
We report the case of a 4-year-old female with a primary extradural intramedullary atypical teratoid/rhabdoid tumor (AT/RT) leading to a middle cerebral artery (MCA) infarct and Froin's syndrome. She presented with a 6-pound weight loss over the previous week, as well as a decreased urinary output and an altered mental status. She underwent a brain MRI that revealed a left MCA infarct, mild ventriculomegaly, and bilateral internal carotid artery, M1, and A1 stenosis. An external ventricular drain (EVD) was placed due to increased intracranial pressure...
November 2, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29129004/multiple-hereditary-osteochondromatosis-with-spinal-cord-compression-case-report
#7
Oscar García-González, J Nicolás Mireles-Cano, Natalia Sánchez-Zavala, Miguel A Chagolla-Santillan, Segio M Orozco-Ramirez, Pedro Silva-Cerecedo, Mario Murguia-Perez, Fernando Rueda-Franco
OBJECTIVE: The purpose of the report is to describe a patient with hereditary osteochondromatosis and spinal cord compression at the thoracic level. CLINICAL FEATURES: An 8-year-old patient with hereditary osteochondromatosis inherited from his father presented paraparesis in the left foot, leading to complete paralysis in both legs. INTERVENTION: In a CT scan, a bony tumor rising from the posterior wall of the T3 body narrowing the spinal canal, and the MRI spinal cord compression at the same level and the hydrosyringomyelic cavity extended to the conus medullaris; with an anterior thoracic approach to T2-T4, the fibro-cartilaginous tumor was removed, and the stabilization was completed with bone graft and a plate...
November 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29123990/the-skeletal-related-events-of-denosumab-versus-zoledronic-acid-in-patients-with-bone-metastases-a-meta-analysis-of-randomized-controlled-trials
#8
Zhicai Zhang, Feifei Pu, Zengwu Shao
Objective: The meta-analysis was used to evaluate the skeletal-related events (SREs) and efficacy of denosumab versus zoledronic acid (ZA) in patients with bone metastases. Methods: The data of this meta-analysis study were searched from PUBMED, EMBASE, Cochrane Library, Web of Science with Conference Proceedings, Elsevier and China National Knowledge Infrastructure (CNKI) databases till August 2017. Two independent reviewers reviewed the reference lists of relevant articles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29122701/predictors-of-quality-of-life-improvement-after-surgery-for-metastatic-tumors-of-the-spine-prospective-cohort-study
#9
Ori Barzilai, Lily McLaughlin, Mary-Kate Amato, Anne S Reiner, Shahiba Q Ogilvie, Eric Lis, Yoshiya Yamada, Mark H Bilsky, Ilya Laufer
BACKGROUND CONTEXT: Surgical decompression and stabilization followed by radiosurgery represents an effective method for local tumor control and neurologic preservation for patients with metastatic epidural spinal cord compression. We have previously demonstrated improvement in HrQOL after this combined modality treatment ("hybrid therapy"). PURPOSE: The current analysis focuses on delineation of patient-specific prognostic factors predictive of HrQOL change after combined surgery-SRS treatment of MESCC...
November 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29115658/combined-and-individual-use-of-pancaspase-inhibitor-q-vd-oph-and-nmda-receptor-antagonist-riluzole-in-experimental-spinal-cord-injury
#10
Halil Can, Aydın Aydoseli, Cengiz Gömleksiz, Burcu Göker, Muhittin Emre Altunrende, Müge Dolgun, Altay Sencer
BACKGROUND: We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury. METHODS: In our study, 45 healthy male Sprague Dawley rats were used. Spinal trauma was induced by the clip compression technique via thoracal 7, 8, 9 laminectomies. After inducing the trauma, the drug was continuously administered intraperitoneally for 5 days...
2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29115099/spinal-meningiomas-61-cases-with-predictors-of-early-postoperative-surgical-outcomes
#11
Ahmed B Bayoumi, Yosef Laviv, Ceren N Karaali, Kemal Ertilav, Umit Kepoglu, Zafer O Toktas, Deniz Konya, Ekkehard M Kasper
BACKGROUND: Spinal meningiomas are benign, well-circumscribed and slowly growing intradural tumors that compress the spinal cord. Hereby, a retrospective review of 61 spinal meningioma cases evaluated in terms of demographic, clinical, pathological and radiological features to predict the early postoperative functional outcomes. METHODS: Patients' records and MRI images of all the histologically confirmed spinal meningioma cases that underwent surgical resection at two university hospitals from January 2005 to June 2016 were retrospectively reviewed...
November 7, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29114289/conus-medullaris-arachnoid-cyst-presenting-as-cauda-equina-syndrome
#12
Salman Sharif, Afifa Afsar, Mohsin Qadeer
Intradural arachnoid cysts are a rare cause of spinal cord and nerve root compression. Primarily, they are present in the thoracic region posteriorly. We report a 25-year-old man who had an intradural arachnoid cyst at the level of conus medullaris presenting with cauda equina syndrome, which is very rare.
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113903/long-term-follow-up-of-metastatic-epidural-spinal-cord-compression-mescc-patients-from-breast-cancer-treated-with-surgery-followed-by-radiotherapy
#13
Federico Pessina, Pierina Navarria, Marco Riva, Davide Franceschini, Marco Conti Nibali, Maurizio Fornari, Marta Scorsetti
BACKGROUND: Aim of this study was to evaluate the role of surgery plus radiotherapy in Metastatic Epidural Spinal Cord Compression (MESCC) breast cancer (BC) patients with a follow-up longer than 10 years. METHODS: Twenty-three patients treated between 2004 and 2008 were included. Surgical treatment was performed in patients with good performance status, limited metastatic disease and progressive neurologic deficit and/or intractable pain. RT was performed delivering a median total dose of 30 Gy in 10 fractions...
November 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29111092/quantitative-neuroimaging-in-mucopolysaccharidoses-clinical-trials
#14
REVIEW
Igor Nestrasil, Leonardo Vedolin
The mucopolysaccharidosis (MPS) disorders are rare lysosomal storage disorders caused by mutations in lysosomal enzymes involved in glycosaminoglycan (GAG) degradation. The resulting intracellular accumulation of GAGs leads to widespread tissue and organ dysfunction. In addition to somatic signs and symptoms, patients with MPS can present with neurological manifestations such as cognitive decline, behavioral problems (e.g. hyperactivity and aggressiveness), sleep disturbances, and/or epilepsy. These are associated with significant abnormalities of the central nervous system (CNS), including white and gray matter lesions, brain atrophy, ventriculomegaly, and spinal cord compression...
September 15, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#15
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
November 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29107727/severe-spinal-cord-compression-by-a-pure-giant-intradural-schwannoma-of-the-cervical-spine
#16
Javier Quillo-Olvera, Guang-Xun Lin, Jin-Sung Kim
A 73-year-old man with progressive quadriparesis, six months of evolution. Physical examination showed decreased strength at upper and lower limbs together with an increase in osteotendinous reflexes with Babinski sign. Upon radiological investigation, MRI revealed a tumor at C3-T2 with a severe ventrolateral displacement of the spinal cord (Figure 1). The patient underwent surgery for gross total resection of the lesion. Histopathologic findings reported a schwannoma. (Figure 2). Muscular strength of the limbs improved three months after surgery, and the patient was able to walk without assistance...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29104840/spinal-shortening-for-recurrent-tethered-cord-syndrome-via-a-lateral-retropleural-approach-a-novel-operative-technique
#17
Jeffrey A Steinberg, Arvin R Wali, Joel Martin, David R Santiago-Dieppa, David Gonda, William Taylor
Spine shortening via vertebral osteotomy (SSVO) for recurrent tethered cord syndrome (TCS) is a novel surgical technique that avoids the complication profile associated with revision detethering. While SSVO has previously been described via a posterior approach, we describe a lateral retropleural approach for SSVO in recurrent TCS in a 21-year-old female. Our patient presented with progressive lower extremity weakness, bowel and bladder incontinence, and back pain in the setting of childhood repair of myelomeningocele and two previous detethering procedures...
August 31, 2017: Curēus
https://www.readbyqxmd.com/read/29104151/high-cervical-spinal-cord-compression-associated-with-anomaly-of-bilateral-vertebral-arteries
#18
Saeko Hayashi, Ryuichi Kanai, Jun Shinoda
BACKGROUND: Anomalies of vertebral arteries are rare, and usually detected incidentally. However, very rarely, they can manifest clinical symptoms. We describe such a symptomatic case of high cervical spinal cord compression associated with persistent C2 segmental arteries. CASE DESCRIPTION: A 67-year-old man presented with a 5-year history of worsening left-sided weakness and gait disturbance. Magnetic resonance imaging, 3D-computed tomography and digital subtraction angiography revealed anomalous courses of vertebral arteries, compressing the cervical spinal cord at C1 level from both sides...
November 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29101314/clinical-and-radiological-analysis-of-bryan-cervical-artificial-disc-replacement-for-skip-multi-segment-cervical-spondylosis-long-term-follow-up-results
#19
Zikun Shang, Yingze Zhang, Di Zhang, Wenyuan Ding, Yong Shen
BACKGROUND The aim of this study was to retrospectively analyze the clinical and radiological efficacy of Bryan cervical artificial disc replacement (ADR) for "skip" multi-segment cervical spondylosis (SCS). MATERIAL AND METHODS We enrolled 49 patients with SCS treated with either Bryan cervical ADR (18 cases) or ACDF (31 cases). Each case was evaluated preoperatively and at more than 48 months postoperatively in follow-up using the JOA, NDI, and VAS. Cervical sagittal curvature, total cervical ROM, and degree of middle segments of motion were also evaluated...
November 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29101074/regression-of-giant-calcified-thoracic-disc-and-spinal-cord-compression-following-thoracic-laminectomy-and-posterior-instrumented-fusion
#20
Fernando Alonso, Manish K Kasliwal
A 55 year old full time employed lady presented with urinary urgency and occasional lower extremity numbness and tingling with motor function preservation. CT and MRI revealed a 20mm x 9mm T10-T11 calcified disc (Figure A, B, C). Anterior and posterior approaches were discussed with the patient along with associated risks such as CSF leak due to possible intradural extension and small but possible risk of new onset motor deficit following disc removal. Considering her almost intact neurological function and to avoid slight albeit realistic morbidity from attempted discectomy regardless of an anterior transthoracic or posterolateral approach, a strategy consisting of a wide long segment T10-T11 laminectomy and T9-T12 posterior instrumented fusion was performed with the assumption that micro motion elimination through a fusion will eliminate dynamic compression from spinal cord draping over the anterior calcified disc fragment...
October 31, 2017: World Neurosurgery
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