keyword
MENU ▼
Read by QxMD icon Read
search

Sirt1 AND Resveratrol

keyword
https://www.readbyqxmd.com/read/27901083/resveratrol-serves-as-a-protein-substrate-interaction-stabilizer-in-human-sirt1-activation
#1
Xuben Hou, David Rooklin, Hao Fang, Yingkai Zhang
Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD(+)-dependent deacetylases. SIRT1 has emerged as an attractive therapeutic target for many aging related diseases, however, how its activity can only be activated toward some specific substrates by resveratrol has been poorly understood. Herein, by employing extensive molecular dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we have clarified current controversies in the literature and elucidated that resveratrol plays an important activation role by stabilizing SIRT1/peptide interactions in a substrate-specific manner...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890623/sirt1-protects-osteoblasts-against-particle-induced-inflammatory-responses-and-apoptosis-in-aseptic-prosthesis-loosening
#2
Zhantao Deng, Zhenheng Wang, Jiewen Jin, Yong Wang, Nirong Bao, Qian Gao, Jianning Zhao
: We hypothesized that SIRT1 downregulation in osteoblasts induced by wear particles was one of the reasons for particle-induced osteolysis (PIO) in total joint arthroplasty failure. In the present study, the expression of SIRT1 was examined in osteoblasts treated with TiAl6V4 particles (TiPs) and CoCrMo particles (CoPs) from materials used in prosthetics and specimens from PIO animal models. To address whether SIRT1 downregulation triggers inflammatory responses and apoptosis in osteoblasts, the effect of a SIRT1 activator, resveratrol on the expression of inflammatory cytokines and apoptosis in particle-treated osteoblasts was tested...
November 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27878240/sirt1-activator-represses-the-transcription-of-tnf%C3%A2-%C3%AE-in-thp%C3%A2-1-cells-of-a-sepsis-model-via-deacetylation-of-h4k16
#3
Guo-Dong Chen, Wei-Dong Yu, Xiao-Ping Chen
Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)‑tolerant THP‑1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF‑α. Chromatin immunoprecipitation and real‑time PCR were used to determine the transcription of the TNF‑α promoter...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27837177/protection-of-resveratrol-on-acute-kidney-injury-in-septic-rats
#4
Y Gan, S Tao, D Cao, H Xie, Q Zeng
AIM: The aim of the study is to investigate protective effect of resveratrol (Res) on acute kidney injury (AKI) in sepsis. METHODS: Rats in sham group received sham operation; in sham + Res received sham operation and Res (3 mg/kg); in cecal ligation and puncture (CLP) established as sepsis; in CLP + Res (3 mg/kg) with sepsis and Res (3 mg/kg); and in CLP + Res (10 mg/kg) with sepsis and Res (10 mg/kg). Survival rate, serum indexes, inflammatory factors, NF-κB-P65, and SIRT1 were detected...
November 11, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27836811/sirt1-ampk-crosstalk-is-involved-in-high-glucose-dependent-impairment-of-insulin-responsiveness-in-primary-rat-podocytes
#5
Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowski
Growing evidence indicates that in diabetes, high glucose concentrations affect podocyte metabolism and function. The crucial pathological feature of type 2 diabetes mellitus and metabolic syndrome is insulin resistance, often developed as a result of dysregulation of nutrient-responsible systems and disturbance of cellular homeostasis under diabetic conditions. Here, we report the involvement of the reciprocal interplay between deacetylase SIRT1 and protein kinase AMPK in podocyte high glucose-induced abolition of insulin-dependent glucose uptake, manifesting insulin resistance...
November 9, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27792110/role-of-sirt1-plays-in-nucleus-pulposus-cells-and-intervertebral-disc-degeneration
#6
Ji Guo, Minghao Shao, Feizhou Lu, Jianyuan Jiang, Xinlei Xia
STUDY DESIGN: Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE: This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potential mechanism in human nucleus pulposus cells. SUMMARY OF BACKGROUND DATA: Silent mating type information regulator 2 homolog 1 (Sirt1) has draw immense attention because of its influence on a variety of aging-related diseases...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27779675/resveratrol-alleviates-sepsis%C3%A2-induced-myocardial-injury-in-rats-by-suppressing-neutrophil-accumulation-the-induction-of-tnf%C3%A2-%C3%AE-and-myocardial-apoptosis-via-activation-of-sirt1
#7
Rui An, Lei Zhao, Jian Xu, Cong Xi, Haixun Li, Guohong Shen, Wei Zhang, Shumiao Zhang, Lijun Sun
Sepsis is a severe inflammatory response to systemic infection that frequently affects the myocardium. Previous studies have suggested that resveratrol (RESV) is protective in sepsis. The present study aimed to investigate the role of sirtuin 1 (Sirt1) signaling in the protective effect of intraperitoneally administered RESV against sepsis‑induced myocardial injury. Cecal ligation and puncture, or a sham operation, were performed in male Sprague‑Dawley rats, and the levels of tumor necrosis factor (TNF)‑α and myeloperoxidase (MPO) were assessed by ELISA and an MPO activity kit, respectively...
October 19, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27764247/sirt1-pgc1%C3%AE-nf%C3%AE%C2%BAb-pathway-of-oxidative-and-inflammatory-stress-during-trypanosoma-cruzi-infection-benefits-of-sirt1-targeted-therapy-in-improving-heart-function-in-chagas-disease
#8
Xianxiu Wan, Jian-Jun Wen, Sue-Jie Koo, Lisa Yi Liang, Nisha Jain Garg
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57BL/6 mice were infected with Trypanosoma cruzi (Tc), treated with SIRT1 agonists (resveratrol or SRT1720), and monitored during chronic phase (~150 days post-infection). Resveratrol treatment was partially beneficial in controlling the pathologic processes in Chagas disease...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27713945/piceatannol-is-superior-to-resveratrol-in-promoting-neural-stem-cell-differentiation-into-astrocytes
#9
Daisuke Arai, Ryousuke Kataoka, Satoshi Otsuka, Midori Kawamura, Hiroko Maruki-Uchida, Masahiko Sai, Tatsuhiko Ito, Yoichi Nakao
Piceatannol (3,3',4',5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4',5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27698537/resveratrol-improves-salivary-dysfunction-in-a-non-obese-diabetic-nod-mouse-model-of-sj%C3%A3-gren-s-syndrome
#10
Hiroko Inoue, Atsuhiro Kishimoto, Ryoko Ushikoshi-Nakayama, Ayaka Hasaka, Ayako Takahashi, Koufuchi Ryo, Takashi Muramatsu, Fumio Ide, Kenji Mishima, Ichiro Saito
Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjögren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice...
September 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27687054/effects-of-trans-resveratrol-on-hyperglycemia-induced-abnormal-spermatogenesis-dna-damage-and-alterations-in-poly-adp-ribose-polymerase-signaling-in-rat-testis
#11
Ala Abdelali, Maie Al-Bader, Narayana Kilarkaje
Diabetes induces oxidative stress, DNA damage and alters several intracellular signaling pathways in organ systems. This study investigated modulatory effects of Trans-Resveratrol on type 1 diabetes mellitus (T1DM)-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase (PARP) signaling in rat testis. Trans-Resveratrol administration (5mg/kg/day, ip) to Streptozotocin-induced T1DM adult male Wistar rats from day 22-42 resulted in recovery of induced oxidative stress, abnormal spermatogenesis and inhibited DNA synthesis, and led to mitigation of 8-hydroxy-2'-deoxyguanosine formation in the testis and spermatozoa, and DNA double-strand breaks in the testis...
September 27, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27659793/downregulation-of-angiotensin-type-1-receptor-and-nuclear-factor-%C3%AE%C2%BAb-by-sirtuin-1-contributes-to-renoprotection-in-unilateral-ureteral-obstruction
#12
Shao-Yu Yang, Shuei-Liong Lin, Yung-Ming Chen, Vin-Cent Wu, Wei-Shiung Yang, Kwan-Dun Wu
Activation of sirtuin 1 (Sirt1) attenuates unilateral ureteral obstruction (UUO)-induced inflammation and fibrosis, suggesting that Sirt1 may prevent tubulointerstitial fibrosis. In this study, we explored changes in the expression of Sirt1 in the kidneys of UUO-treated rats and evaluated the effects of Sirt1 activation or inhibition on renal pathology and mediators of UUO pathogenesis, especially angiotensin II and nuclear factor (NF)-κB, in rats and rat renal fibroblasts. Sirt1 expression increased in the obstructed kidney but not in the contralateral kidney and was mainly detected in tubulointerstitial cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27643555/resveratrol-ameliorates-lps-induced-acute-lung-injury-via-nlrp3-inflammasome-modulation
#13
Lei Jiang, Lei Zhang, Kai Kang, Dongsheng Fei, Rui Gong, Yanhui Cao, Shangha Pan, Mingran Zhao, Mingyan Zhao
NLRP3 inflammasome plays a pivotal role in the development of acute lung injury (ALI), accelerating IL-1β and IL-18 release and inducing lung inflammation. Resveratrol, a natural phytoalexin, has anti-inflammatory properties via inhibition of oxidation, leukocyte priming, and production of inflammatory mediators. In this study, we aimed to investigate the effect of resveratrol on NLRP3 inflammasome in lipopolysaccharide-induced ALI. Mice were intratracheally instilled with 3mg/kg lipopolysaccharide (LPS) to induce ALI...
September 16, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27613163/resveratrol-supplement-inhibited-the-nf-%C3%AE%C2%BAb-inflammation-pathway-through-activating-ampk%C3%AE-sirt1-pathway-in-mice-with-fatty-liver
#14
Yueli Tian, Jingting Ma, Wudong Wang, Lingjuan Zhang, Jia Xu, Kai Wang, Dongfu Li
Nonalcoholic fatty liver disease (NAFLD) is characterized by high levels of nonesterified fatty acids (NEFA), inflammation, and hepatic steatosis. Inflammation plays a crucial role in the development of fatty liver. Resveratrol (RSV) supplement could improve inflammatory response and hepatic steatosis, whereas the underlying mechanism was not well understood. In this study, mice fed with high-fat diet (HFD) exhibited severe hepatic injury and high blood concentrations of the inflammatory cytokines TNF-α, IL-6, and IL-1β...
November 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27600946/resveratrol-ameliorates-spatial-learning-memory-impairment-induced-by-a%C3%AE-1-42-in-rats
#15
Rui Wang, Yu Zhang, Jianguo Li, Ce Zhang
β-amyloid (Aβ) deposition is considered partially responsible for cognitive dysfunction in Alzheimer's disease (AD). Recently, resveratrol has been reported to play a potential role as a neuroprotective biofactor by modulating Aβ pathomechanisms, including through anti-neuronal apoptotic, anti-oxidative stress, and anti-neuroinflammatory effects. In addition, SIRT1 has been demonstrated to modulate learning and memory function by regulating the expression of CREB, which involves in modulating the expression of SIRT1...
September 3, 2016: Neuroscience
https://www.readbyqxmd.com/read/27590140/comparative-mitochondrial-based-protective-effects-of-resveratrol-and-nicotinamide-in-huntington-s-disease-models
#16
Luana Naia, Tatiana R Rosenstock, Ana M Oliveira, Sofia I Oliveira-Sousa, Gladys L Caldeira, Catarina Carmo, Mário N Laço, Michael R Hayden, Catarina R Oliveira, A Cristina Rego
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological mechanisms in Huntington's disease (HD), a neurodegenerative disease that selectively affects the striatum and cortex and is commonly linked to mitochondrial dysfunction. Thus, in this study, we tested the influence of resveratrol (RESV, a SIRT1 activator) versus nicotinamide (NAM, a SIRT1 inhibitor) in counteracting mitochondrial dysfunction in HD models, namely striatal and cortical neurons isolated from YAC128 transgenic mice embryos, HD human lymphoblasts, and an in vivo HD model...
September 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27582325/resveratrol-protects-against-high-fat-diet-induced-renal-pathological-damage-and-cell-senescence-by-activating-sirt1
#17
Nannan Zhang, Zhongchi Li, Kang Xu, Yanying Wang, Zhao Wang
Obesity-related renal diseases have been a worldwide issue. Effective strategy that prevents high fat-diet induced renal damage is of great significance. Resveratrol, a natural plant polyphenol, is famous for its antioxidant activity, cardioprotective effects and anticancer properties. However whether resveratrol can play a role in the treatment of renal diseases is unknown. In this study, we added resveratrol in normal glucose or high glucose medium and provide evidences that resveratrol protects against high-glucose triggered oxidative stress and cell senescence...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27579780/high-mobility-group-box-1-mediates-interferon-%C3%AE-induced-phenotypic-modulation-of-vascular-smooth-muscle-cells
#18
Kun Wang, Wei Li, Qihong Yu, Bing Guo, Bin Yang, Chen Zhang, Min Li, Jinjin Li, Shaobo Hu, Qichang Zheng, Zifang Song
The phenotypic modulation of VSMCs is a key cellular event driving neointimal formation and vascular remodeling. As a multifaceted cytokine of cell-mediated immunity, IFN-γ has been shown to play a critical role in the pathogenesis of vascular proliferative diseases. Although the important function of IFN-γ on regulating VSMC activation is well established, the molecular mechanisms by which elicits VSMC responses are poorly defined. Recent studies have identified HMGB1 as a principal effector to mediate IFN-γ-dependent biological functions in multiple cell types...
August 31, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27573670/sirtuin-1-mediates-the-actions-of-peroxisome-proliferator-activated-receptor-%C3%AE-on-the-oxidized-low-density-lipoprotein-triggered-migration-and-proliferation-of-vascular-smooth-muscle-cells
#19
Jung Seok Hwang, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Kyung Shin Paek, Chi-Ho Lee, Han Geuk Seo
Peroxisome proliferator-activated receptor δ (PPARδ) has been implicated in vascular pathophysiology. However, its functions in atherogenic changes of the vascular wall have not been fully elucidated. PPARδ activated by GW501516 (2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid) significantly inhibited the migration and proliferation of vascular smooth muscle cells (VSMCs) triggered by oxidized low-density lipoprotein (oxLDL). These GW501516-mediated effects were significantly reversed by PPARδ-targeting small-interfering RNA (siRNA), indicating that PPARδ is involved in the action of GW501516...
November 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/27552971/slowing-ageing-by-design-the-rise-of-nad-and-sirtuin-activating-compounds
#20
Michael S Bonkowski, David A Sinclair
The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD(+))-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD(+) precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others...
November 2016: Nature Reviews. Molecular Cell Biology
keyword
keyword
71915
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"