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Sirt1 AND Resveratrol

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https://www.readbyqxmd.com/read/29775898/particle-induced-sirt1-downregulation-promotes-osteoclastogenesis-and-osteolysis-through-er-stress-regulation
#1
Liang Zhang, Dongmei Bao, Peng Li, Zhidong Lu, Long Pang, Zhirong Chen, Haohui Guo, Zhihui Gao, Qunhua Jin
BACKGROUND: Sirtuin 1 (SIRT1) downregulation has been found to be induced by wear particles in aseptic prosthesis loosening (APL). Osteoclastogenesis and osteoclast activation are the main pathological factors associated with APL. However, whether SIRT1 downregulation contributes to the formation and activation of osteoclasts through the induction of endoplasmic reticulum (ER) stress is unclear. METHODS: To address this, an osteolysis mouse model was used in which animals were treated with the SIRT1 activator, resveratrol (RES), or an ER stress inhibitor, 4-PBA, for two weeks...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29762078/resveratrol-promoted-interferon-%C3%AE-induced-growth-inhibition-and-apoptosis-of-smmc7721-cells-by-activating-the-sirt-stat1
#2
Zhanchun Yang, Qingyu Meng, Yuying Zhao, Rui Han, Shishun Huang, Meiqi Li, Xuan Wu, Wenna Cai, Haihe Wang
Interferon-α (IFN-α) resistance is a major hurdle in the treatment of hepatocellular carcinoma (HCC). Signal transducers and activators of transcription 1 (STAT1) play a key role in exerting the antiproliferative and proapoptotic effects of IFN-α on tumors. In this study, we aimed to investigate whether resveratrol can promote IFN-α-induced growth inhibition and the apoptosis on HCC cells through the SIRT/STAT1 pathway. We found that IFN-α induced growth inhibition and apoptosis of SMMC7721 cells, and the effects could be significantly enhanced and blocked by resveratrol and EX527, respectively...
May 15, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29758202/mounting-evidence-validates-ursolic-acid-directly-activates-sirt1-a-powerful-stac-which-mimic-endogenous-activator-of-sirt1
#3
Nuredin Bakhtiari, Sako Mirzaie, Roohullah Hemmati, Elham Moslemee-Jalalvand, Ali Reza Noori, Jahanfard Kazemi
Ursolic Acid (UA), a pentacyclic triterpenoid compound, plays a vital role in aging process. However, the role of UA in the regulation of aging and longevity is still controversial as we have previously demonstrated that UA increases SIRT1 protein level in aged-mice. Here, we reveal that UA directly activates SIRT1 in silico, in vitro and in vivo. We have identified that UA binds to outer surface of SIRT1 and leads to tight binding of substrates to enzyme in comparison with Resveratrol (RSV) and control. Furthermore, our results indicate that UA drives the structure of SIRT1 toward a closed state (an active form of enzyme)...
May 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29719779/a-pilot-study-of-the-modulation-of-sirtuins-on-arylamine-n-acetyltransferase-1-and-2-enzymatic-activity
#4
Eneida Turiján-Espinoza, Rául Alejandro Salazar-González, Edith Elena Uresti-Rivera, Gloria Estela Hernández-Hernández, Montserrat Ortega-Juárez, Rosa Milán, Diana Portales-Pérez
Arylamine N -acetyltransferase (NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide, which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2, SIRT1 and SIRT6 in peripheral blood mononuclear cells (PBMC) from healthy subjects were examined by flow cytometry and Western blot...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29715537/resveratrol-prevents-cognitive-deficits-induced-by-chronic-unpredictable-mild-stress-sirt1-mir-134-signalling-pathway-regulates-creb-bdnf-expression-in-hippocampus-in-vivo-and-in-vitro
#5
Jun Shen, Linling Xu, Chujie Qu, Huimin Sun, Junjian Zhang
Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, such as depression, anxiety and cognitive impairment. Resveratrol is a natural polyphenol existed in polygonum cuspidatum and has been demonstrated to be a potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol treatment ameliorated CUMS-induced depressive-like behavior and cognitive deficits through upregulating cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression...
April 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29713468/dietary-resveratrol-improves-antioxidant-status-of-sows-and-piglets-and-regulates-antioxidant-gene-expression-in-placenta-by-keap1-nrf2-pathway-and-sirt1
#6
Qingwei Meng, Tao Guo, Gaoqiang Li, Shishuai Sun, Shiqi He, Baojing Cheng, Baoming Shi, Anshan Shan
Background: Resveratrol, a plant phenol, affords protection against inflammation and oxidative stress. The objective of this study was to investigate the effects of dietary resveratrol supplementation during pregnancy and lactation on the antioxidant status of sows and piglets and on antioxidant gene expression and pathway in placenta. Methods: Forty sows were allotted to 2 dietary treatments 20 d after breeding. Sows were fed a control diet and a control diet with 300 mg/kg resveratrol...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29680708/sirt1-mediates-apelin-13-in-ameliorating-chronic-normobaric-hypoxia-induced-anxiety-like-behavior-by-suppressing-nf-%C3%AE%C2%BAb-pathway-in-mice-hippocampus
#7
Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gong
We previously showed that apelin-13 ameliorates chronic normobaric hypoxia (CNH)-induced anxiety-like behavior in mice, the mechanism, however, is not well known. This study aims to investigate whether SIRT1 is involved in the anxiolytic effect of apelin-13 in CNH-treated mice, and to illustrate the potential underlying mechanism. We showed that apelin-13 treatment reversed a decrease of SIRT1 and an increase of acetylated p65 (lysine 310) proteins expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-κB signaling pathway by activating SIRT1...
April 19, 2018: Neuroscience
https://www.readbyqxmd.com/read/29624568/resveratrol-attenuates-lipopolysaccharides-lps-induced-inhibition-of-osteoblast-differentiation-in-mc3t3-e1-cells
#8
Jun Ma, Zhu Wang, Jianquan Zhao, WuJun Miao, TianWen Ye, Aimin Chen
BACKGROUND LPS-inhibited osteoblastic differentiation plays an important role in the pathogenesis of osteomyelitis. Thus, searching for drugs that affect LPS-mediated osteoblastic differentiation may be crucial in developing therapies for osteomyelitis. The purpose of this study was to investigate the role and mechanisms of resveratrol, a natural polyphenol present in red wine, on LPS-inhibited osteoblastic differentiation. MATERIAL AND METHODS Cell viability was measured by MMT assay. Mitochondrial ATP levels, membrane potential, and superoxide production were measured to evaluate the effects of LPS and resveratrol on mitochondrial functions in osteoblast-like MC3T3-E1 cells...
April 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29614660/stimulation-of-sirt1-attenuates-the-level-of-oxidative-stress-in-the-brains-of-app-ps1-double-transgenic-mice-and-in-primary-neurons-exposed-to-oligomers-of-the-amyloid-%C3%AE-peptide
#9
Yang-Ting Dong, Kun Cao, Long-Chun Tan, Xiao-Ling Wang, Xiao-Lan Qi, Yan Xiao, Zhi-Zhong Guan
In the study, we examined whether the silent information regulator 1 (SIRT1) can attenuate oxidative stress in the brains of mice carrying the APP/PS1 double mutation and/or in primary neonatal rat neurons exposed to oligomers of amyloid-β peptide (AβOs). Starting at 4 or 8 months of age, the transgenic mice were treated with resveratrol (RSV, a stimulator of SIRT1) or suramin (an inhibitor) (each 20 mg/kg BW/day) for two months. The primary neurons were exposed to AβOs (0.5 μM) for 48 h and thereafter RSV (20 μM) or suramin (300 mg/ml) for 24 h...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29609003/fluoride-induces-apoptosis-via-inhibiting-sirt1-activity-to-activate-mitochondrial-p53-pathway-in-human-neuroblastoma-sh-sy5y-cells
#10
Wei Tu, Qian Zhang, Yin Liu, Lianyong Han, Qin Wang, Panpan Chen, Shun Zhang, Aiguo Wang, Xue Zhou
There has been a great concern about the neurotoxicity of fluoride since it can pass through the blood-brain barrier and accumulate in the brain. It has been suggested that apoptosis plays a vital role in neurotoxicity of fluoride. However, whether p53-mediated apoptotic pathway is involved is still unclear. Our results showed that apoptosis was induced after treatment with 40 and 60 mg/L of NaF for 24 h in human neuroblastoma SH-SY5Y cells. Exposure to 60 mg/L of NaF for 24 h significantly upregulated the levels of p53 and apoptosis-related proteins including PUMA, cytochrome c (cyto c), cleaved caspase-3 and cleaved PARP, whereas downregulated Bcl-2 in SH-SY5Y cells...
March 30, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29600625/-effect-of-microrna-34a-sirt1-p53-signal-pathway-on-notoginsenoside-r%C3%A2-delaying-vascular-endothelial-cell-senescence
#11
Xiao-Hua Lai, Yan Lei, Jing Yang, Cheng-Kui Xiu
This study aimed to investigate the effect of notoginsenoside R₁ in delaying H₂O₂-induced vascular endothelial cell senescence through microRNA-34a/SIRT1/p53 signal pathway. In this study, human umbilical vein endothelial cells(HUVECs) were selected as the study object; the aging model induced by hydrogen peroxide(H₂O₂) was established, with resveratrol as the positive drug. HUVECs were randomly divided into four groups, youth group, senescence model group, notoginsenoside R₁ group and resveratrol group...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29588426/potential-benefits-of-a-sulfated-resveratrol-derivative-for-topical-application
#12
Marta Correia-da-Silva, Verónica Rocha, Cláudia Marques, Cláudia Deus, Adriana Marques-Carvalho, Paulo Oliveira, Andreia Palmeira, Madalena Pinto, Maria Emília Sousa, José Sousa Lobo, Isabel Almeida
Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory, and anti-aging properties partly associated with sirtuin-1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion, and measurement of ATP concentration...
March 27, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29571747/cdk5-suppression-blocks-sirt1-degradation-via-the-ubiquitin-proteasome-pathway-in-parkinson-s-disease-models
#13
Qian Zhang, Pei Zhang, Guang-Jian Qi, Zheng Zhang, Feng He, Ze-Xi Lv, Xiang Peng, Hong-Wei Cai, Tong-Xia Li, Xue-Min Wang, Bo Tian
The NAD+ -dependent protein deacetylase sirtuin 1 (SIRT1), a member of the sirtuin family, may have a neuroprotective effect in multiple neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). Many studies have suggested that overexpression-induced or resveratrol-treated activation of SIRT1 could significantly ameliorate several neurodegenerative diseases in mouse models. However, the type of SIRT1, protein expression levels and underlying mechanisms remain unclear, especially in PD...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29554499/resveratrol-improves-glucose-uptake-in-insulin-resistant-adipocytes-via-sirt1
#14
Sifan Chen, Zhongliang Zhao, Liangru Ke, Zilun Li, Wenxue Li, Zili Zhang, Ying Zhou, Xiang Feng, Wei Zhu
Insulin resistance serves as "common soil" for promoting the development of metabolic diseases; however, the precise pathological factors leading to insulin resistance are not well clarified. Resveratrol (Res) is a natural polyphenolic compound with anti-inflammatory and antioxidative effects. However, effects and mechanisms of Res on glucose metabolism in adipocytes remain largely unknown. In this study, we show Res treatment significantly increases glucose uptake in insulin-resistant 3T3-L1 adipocytes in vitro...
February 13, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29550483/strigolactone-gr24-and-pinosylvin-attenuate-adipogenesis-and-inflammation-of-white-adipocytes
#15
Shalem Modi, Nagendra Yaluri, Tarja Kokkola
Obesity is characterized by excess fat accumulation in white adipose tissue, which triggers chronic low-grade inflammation through secretion of pro-inflammatory factors by the enlarged adipocytes and infiltrated macrophages. This affects glucose and lipid metabolism in adipose tissue, inducing type 2 diabetes. NAD+ -dependent deacetylase SIRT1 is known to inhibit adipogenesis through the regulation of the key adipogenic transcription factors, PPARγ and C/EBPα. SIRT1 activators such as resveratrol inhibit adipogenesis and exert anti-inflammatory responses in the adipose tissue...
March 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29514131/potential-of-resveratrol-in-mitigating-metabolic-disturbances-induced-by-ethanol
#16
REVIEW
Tomasz Szkudelski, Katarzyna Szkudelska
Alcohol abuse is associated with numerous health problems, including metabolic disturbances and liver damage. Therefore, different compounds are continuously being tested to evaluate their potential effectiveness in reducing these harmful changes. Animal studies clearly show that resveratrol is capable of ameliorating some consequences of ethanol ingestion. Resveratrol is a naturally occurring diphenolic compound having pleiotropic, health-promoting properties. Its beneficial action have been also demonstrated in animal models with ethanol-induced metabolic disturbances and liver injury...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29486220/sirt1-suppresses-high-glucose-and-palmitate-induced-osteoclast-differentiation-via-deacetylating-p66shc
#17
Bo Qu, Kai Gong, Hongsheng Yang, Yugang Li, Tao Jiang, Zhimou Zeng, Zongrui Cao, Xianming Pan
Findings concerning the role of diabetes mellitus (DM) in osteoclast differentiation are contradictory in vivo and in vitro. Sirtuin 1 (SIRT1) can inhibit RANKL-induced osteoclastogenesis and deacetylate p66Shc suppress its phosphorylation in high glucose (HG)-stimulated human umbilical vein endothelial cells. This study aimed to investigate the role and mechanism of SIRT1 in DM-related osteoclast differentiation. Osteoclast precursors were cultured with HG and palmitate (PA), with or without resveratrol/sirtinol...
February 24, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29480757/pdgfr-%C3%AE-modulates-vascular-smooth-muscle-cell-phenotype-via-irf-9-sirt-1-nf-%C3%AE%C2%BAb-pathway-in-subarachnoid-hemorrhage-rats
#18
Weifeng Wan, Yan Ding, Zongyi Xie, Qian Li, Feng Yan, Enkhjargal Budbazar, William J Pearce, Richard Hartman, Andre Obenaus, John H Zhang, Yong Jiang, Jiping Tang
Platelet-derived growth factor receptor-β (PDGFR-β) has been reported to promote phenotypic transformation of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the role of the PDGFR-β/IRF9/SIRT-1/NF-κB pathway in VSMC phenotypic transformation after subarachnoid hemorrhage (SAH). SAH was induced using the endovascular perforation model in Sprague-Dawley rats. PDGFR-β small interfering RNA (siRNA) and IRF9 siRNA were injected intracerebroventricularly 48 h before SAH. SIRT1 activator (resveratrol) and inhibitor (EX527) were administered intraperitoneally 1 h after SAH induction...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29466794/foxo1-a-potential-therapeutic-target-regulates-autophagic-flux-oxidative-stress-mitochondrial-dysfunction-and-apoptosis-in-human-cholangiocarcinoma-qbc939-cells
#19
Wei He, Aiqing Zhang, Lei Qi, Chen Na, Rui Jiang, Zhining Fan, Jianping Chen
BACKGROUND/AIMS: Autophagy is an evolutionarily conserved catabolic mechanism to maintain energy homeostasis and to remove damaged cellular components, which plays an important role in the survival of various cells. Inhibiting autophagy is often applied as a new strategy to halt the growth of cancer cells. METHODS: The effect of FOXO1 gene on cellular function and apoptosis and its underlying mechanisms were investigated in cultured QBC939 cells by the methylthiazoletetrazolium (MTT) assay, western blot, DCFDA mitochondrial membrane potential, and ATP content measurement...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29432917/polyphenol-extracts-from-dried-sugarcane-inhibit-inflammatory-mediators-in-an-in-vitro-colon-cancer-model
#20
Daniel Bucio-Noble, Liisa Kautto, Christoph Krisp, Malcolm S Ball, Mark P Molloy
Sugarcane is an important crop grown in tropical regions for sugar, and for ethanol production. Sugarcane is also a source of phytochemicals but its nutraceutical potential has been under-explored. We show that ethanol extracts of whole dried sugarcane (WDS) recovers a rich content of polyphenols, flavonoids and antioxidant activity that act on inflammatory mediator proteins. To investigate the mechanisms of this activity, we stimulated SW480 colon cancer cells with lipopolysaccharide, exposed cells to WDS and quantitated changes to the proteome and phosphoproteome using label-free mass spectrometry...
April 15, 2018: Journal of Proteomics
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