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Sirt1 AND Resveratrol

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https://www.readbyqxmd.com/read/29331532/high-fat-diet-mediates-anxiolytic-like-behaviors-in-a-time-dependent-manner-through-the-regulation-of-sirt1-in-the-brain
#1
Liu Xu, Shuang Xu, Lifang Lin, Xi Gu, Congcong Fu, Yingying Fang, Xiaowen Li, Xuemin Wang
The consumption of a high-fat diet (HFD) and obesity have been associated not only with metabolic diseases but also with neuropsychiatric diseases, such as depression and anxiety. However, results on the effects of an HFD on anxiety are controversial, since both anxiogenic and anxiolytic effects have been reported. In this study, we evaluated the effects of both short- and long-term intake of an HFD on anxiety-like behaviors. To explore the impact of time on the association between an HFD and anxiety, mice were fed with an HFD for 4 weeks or 12 weeks...
January 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29326403/resveratrol-an-nrf2-activator-ameliorates-aging-related-progressive-renal-injury
#2
Eun Nim Kim, Ji Hee Lim, Min Young Kim, Tae Hyun Ban, In-Ae Jang, Hye Eun Yoon, Cheol Whee Park, Yoon Sik Chang, Bum Soon Choi
BACKGROUND: Two important issues in the aging kidney are mitochondrial dysfunction and oxidative stress. An Nrf2 activator, resveratrol, is known to have various effects. Resveratrol may prevent inflammation and oxidative stress by activating Nrf2 and SIRT1 signaling. We examined whether resveratrol could potentially ameliorate the cellular condition, such as renal injury due to cellular oxidative stress and mitochondrial dysfunction caused by aging. METHODS: Male 18-month-old C57BL/6 mice were used...
January 11, 2018: Aging
https://www.readbyqxmd.com/read/29319388/woohwangcheongsimwon-prevents-high-fat-diet-induced-memory-deficits-and-induces-sirt1-in-mice
#3
Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maeng
Woohwangcheongsimwon (WHC) is a mixture of herbal medicines that is widely prescribed in Korean traditional medicine. SIRT1 is known for its regulatory roles in energy metabolism, oxidative stress, and circadian rhythms. This study was designed to determine whether WHC can increase and mimic the biological reactions of SIRT1 activation. Ten-month-old male mice were divided into four groups: nontreated normal diet (ND), nontreated high-fat diet (HFD), WHC-treated ND, and WHC-treated HFD. Body weight and cognitive functions were evaluated after treatment...
January 10, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29312829/formononetin-inhibits-lipopolysaccharide-induced-release-of-high-mobility-group-box-1-by-upregulating-sirt1-in-a-ppar%C3%AE-dependent-manner
#4
Jung Seok Hwang, Eun Sil Kang, Sung Gu Han, Dae-Seog Lim, Kyung Shin Paek, Chi-Ho Lee, Han Geuk Seo
Background: The release of high mobility group box 1 (HMGB1) induced by inflammatory signals acts as a cellular alarmin to trigger a chain of inflammatory responses. Although the inflammatory actions of HMGB1 are well studied, less is known about the therapeutic agents that can impede its release. This study investigated whether the isoflavonoid formononetin can modulate HMGB1 release in cellular inflammatory responses. Methods: RAW264.7 murine macrophages were exposed to lipopolysaccharide (LPS) in the presence or absence of formononetin...
2018: PeerJ
https://www.readbyqxmd.com/read/29299128/estrogen-modulates-vascular-smooth-muscle-cell-function-through-downregulation-of-sirt1
#5
Chien-Hsing Lee, Sheng-Chiang Su, Chi-Fu Chiang, Chu-Yen Chien, Chia-Chen Hsu, Tzu-Yi Yu, Shih-Ming Huang, Yi-Shing Shieh, Hong-Wei Kao, Chien-Sung Tsai, Yi-Jen Hung, Chih-Yuan Lin
Background: There are sex differences in the incidence and severity of cardiovascular disease. Although an estrogen-mediated vasculoprotective effect is widely accepted, clinical trial results have been conflicting and the detailed mechanisms are still unclear. Sirtuin 1 (SIRT1), a class III histone deacetylase, may protect against vascular aging and atherosclerosis; however, the effects of estrogen on SIRT1 expression and vascular smooth muscle cell (VSMC) behavior remain unknown. Materials and Methods: We ovariectomized (OVX) female, wild-type, C57BL/6J mice, which were randomized into non-estrogen- and estrogen-supplemented groups...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285143/combination-treatment-with-quercetin-and-resveratrol-attenuates-high-fat-diet-induced-obesity-and-associated-inflammation-in-rats-via-the-ampk%C3%AE-1-sirt1-signaling-pathway
#6
Le Zhao, Fang Cen, Feng Tian, Min-Jie Li, Qi Zhang, Hong-Yi Shen, Xiang-Chun Shen, Ming-Mei Zhou, Jun Du
Diet-induced obesity is associated with systemic inflammation, which is considered to originate predominantly from the adipose tissue. Quercetin and resveratrol are two dietary polyphenols that exhibit anti-inflammatory properties and anti-insulin resistance when administered in isolation or combination (CQR). It remains unknown whether CQR reduces high fat diet (HFD)-induced obesity and inflammation in rats. In the current study, 46 male Wistar rats were divided into two groups, one of which was fed a normal diet (ND, 5...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29242624/plant-derived-compounds-strigolactone-gr24-and-pinosylvin-activate-sirt1-and-enhance-glucose-uptake-in-rat-skeletal-muscle-cells
#7
Shalem Modi, Nagendra Yaluri, Tarja Kokkola, Markku Laakso
Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue. We hypothesised that the novel plant-derived compounds, strigolactone and pinosylvin, beneficially enhance SIRT1 function, insulin signalling, glucose uptake, and mitochondrial biogenesis in skeletal muscle cells...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234485/regulation-of-sirtuin-mediated-protein-deacetylation-by-cardioprotective-phytochemicals
#8
REVIEW
Niria Treviño-Saldaña, Gerardo García-Rivas
Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29233982/cacul1-reciprocally-regulates-sirt1-and-lsd1-to-repress-ppar%C3%AE-and-inhibit-adipogenesis
#9
Min Jun Jang, Ui-Hyun Park, Jeong Woo Kim, Hanbyeul Choi, Soo-Jong Um, Eun-Joo Kim
Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation and is closely linked to the development of obesity. Despite great progress in elucidating the transcriptional network of PPARγ, epigenetic regulation of this pathway by histone modification remains elusive. Here, we found that CDK2-associated cullin 1 (CACUL1), identified as a novel SIRT1 interacting protein, directly bound to PPARγ through the co-repressor nuclear receptor (CoRNR) box 2 and repressed the transcriptional activity and adipogenic potential of PPARγ...
December 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29213353/resveratrol-prevents-ros-induced-apoptosis-in-high-glucose-treated-retinal-capillary-endothelial-cells-via-the-activation-of-ampk-sirt1-pgc-1%C3%AE-pathway
#10
Jun Li, Songping Yu, Jia Ying, Tianyan Shi, Peipei Wang
Resveratrol (RSV) is used as a protective therapy against diabetic retinopathy. However, the mechanism(s) underlying this protective effect has not been fully elucidated. Bovine retinal capillary endothelial cells (BRECs), an in vitro model, were used to investigate the mechanism of RSV. Our results showed that high glucose induced significant cellular apoptosis in BRECs, which was accompanied by increased intracellular levels of reactive oxygen species (ROS) and cleaved caspase-3. The glucose-induced apoptosis and ROS elevation were both inhibited by RSV...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29201361/quercetin-prevents-spinal-motor-neuron-degeneration-induced-by-chronic-excitotoxic-stimulus-by-a-sirtuin-1-dependent-mechanism
#11
Rafael Lazo-Gomez, Ricardo Tapia
Background: Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders. Polyphenols, such as quercetin and resveratrol, are plant-derived compounds that activate sirtuins (SIRTs) and have shown promising results in some models of neuronal death, although their effects have been scarcely tested in models of motor neuron degeneration. Methods: In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) into the rat spinal cord tissue...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29201214/sirt1-regulates-apoptosis-and-extracellular-matrix-degradation-in-resveratrol-treated-osteoarthritis-chondrocytes-via-the-wnt-%C3%AE-catenin-signaling-pathways
#12
Shuan Liu, Hongping Yang, Bing Hu, Mingyong Zhang
Osteoarthritis (OA) has become a major public health problem with the increased aging population. Previous studies have demonstrated that resveratrol (RES) was able to increase the level of sirtuin 1 (Sirt1) in OA chondrocytes. However, further investigations are required to elucidate the precise molecular mechanism of RES and the potential link between Sirt1 and RES. Therefore, the present study used 30 clinical OA chondrocyte to examine chondrocyte viability, apoptosis rate and the mRNA and protein expression levels of Sirt1 and relevant genes implicated in apoptosis, extracellular matrix (ECM) degradation and Wnt/β-catenin signaling pathway...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201210/protective-effects-of-resveratrol-on-osteoporosis-via-activation-of-the-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway-in-rats
#13
Xiaowei Wang, Liaobin Chen, Wei Peng
The aim of the present study was to determine the protective effects of resveratrol on a rat model of osteoporosis and examine the associated mechanisms of its action. Rats were randomized into the following groups: Control, osteoporosis, osteoporosis + low-dose resveratrol, osteoporosis + middle-dose resveratrol and osteoporosis + high-dose resveratrol groups. Resveratrol treatment was administered 7 days after surgery for 8 weeks. ELISA assay was used to analyze alkaline phosphatase (ALP) and osteocalcin (OC) protein levels...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29189984/the-role-of-resveratrol-on-skeletal-muscle-cell-differentiation-and-myotube-hypertrophy-during-glucose-restriction
#14
Hannah F Dugdale, David C Hughes, Robert Allan, Colleen S Deane, Christopher R Coxon, James P Morton, Claire E Stewart, Adam P Sharples
Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that resveratrol treatment would improve muscle cell differentiation and myotube hypertrophy in differentiating C2C12 myoblasts and mature myotubes during GR. Glucose restriction at 0.6 g/L (3.3 mM) blocked differentiation and myotube hypertrophy versus high-glucose (4...
November 30, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29185024/sirt1-overexpression-suppresses-fluoride-induced-p53-acetylation-to-alleviate-fluoride-toxicity-in-ameloblasts-responsible-for-enamel-formation
#15
Maiko Suzuki, Atsushi Ikeda, John D Bartlett
Low-dose fluoride is an effective caries prophylactic, but high-dose fluoride is an environmental health hazard that causes skeletal and dental fluorosis. Treatments to prevent fluorosis and the molecular pathways responsive to fluoride exposure remain to be elucidated. Previously we showed that fluoride activates SIRT1 as an adaptive response to protect cells. Here, we demonstrate that fluoride induced p53 acetylation (Ac-p53) [Lys379], which is a SIRT1 deacetylation target, in ameloblast-derived LS8 cells in vitro and in enamel organ in vivo...
November 28, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29177909/stem-cells-and-progenitors-in-human-peripheral-blood-get-activated-by-extremely-active-resveratrol-xar%C3%A2
#16
Vinaykumar Tripathi, Sagar Chhabria, Vaibhav Jadhav, Deepa Bhartiya, Ashish Tripathi
Resveratrol generated enormous interest as it improved functions of multiple organs and could delay aging in animal models. However, basic mechanism of action was not understood and due to poor bioavailability, it has failed to enter the market. A highly active nano-formulation of resveratrol (XAR™) with enhanced bioavailability is now available. Present study was undertaken to evaluate its effects on stem cells biology in the human peripheral blood. Twelve healthy participants were enrolled of which five received XAR™, five were age-matched placebo controls and two were 76 and 85 years old...
November 24, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29175458/tm4sf1-regulates-apoptosis-cell-cycle-and-ros-metabolism-via-the-ppar%C3%AE-sirt1-feedback-loop-in-human-bladder-cancer-cells
#17
Rui Cao, Gang Wang, Kaiyu Qian, Liang Chen, Lingao Ju, Guofeng Qian, Chin-Lee Wu, Han C Dan, Wei Jiang, Min Wu, Yu Xiao, Xinghuan Wang
Transmembrane-4-L-Six-Family-1 (TM4SF1) is a member of the L6 family and functions as a signal transducer to regulate cell development, growth and motility. Here we show that TM4SF1 is strongly upregulated in human muscle invasive bladder cancer (MIBC) tissues, corroborating the bioinformatical results of transcriptome analysis. Moreover, tissue microarray (TMA) shows significant correlations (p < 0.05) between high expression of TM4SF1 and T stage, TNM stage, lymph node metastasis status and survival rate of MIBC patients, indicating a positive association between TM4SF1 expression and poorer prognosis...
November 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29172079/design-syntheses-and-lipid-accumulation-inhibitory-activities-of-novel-resveratrol-mimics
#18
Chanjuan Li, Bao Cheng, Sai Fang, Huihao Zhou, Qiong Gu, Jun Xu
Hispidine was initially discovered from Ficus Hispida for cardiovascular protection. In this paper, hispidine derivatives, which contain a novel resveratrol-like scaffold, have been designed, synthesized, and assayed as agents against lipid accumulations in 3T3-L1 pre-adipocytes. Six hispidine derivatives have the activity of reducing TG in 3T3-L1 adipocytes in dosage-dependent manner. The most active compound can reduce the lipid accumulation up to 78.4% at 10 μM qPCR and Western blotting results demonstrate that the two most active compounds inhibit both lipodenesis and adipogenesis in 3T3-L1 cells through (1) increasing the phosphorylations of AMPK and ACC, promoting SIRT1 expression...
November 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29164153/sirt1-regulates-cognitive-performance-and-ability-of-learning-and-memory-in-diabetic-and-nondiabetic-models
#19
REVIEW
Yue Cao, Zi Yan, Tong Zhou, Guixia Wang
Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29163756/effect-of-chronic-administration-of-resveratrol-on-cognitive-performance-during-aging-process-in-rats
#20
A R Navarro-Cruz, R Ramírez Y Ayala, C Ochoa-Velasco, E Brambila, R Avila-Sosa, S Pérez-Fernández, J C Morales-Medina, P Aguilar-Alonso
The increase in the elderly population has generated concern to meet health demands. The research efforts to elucidate the mechanisms of damage associated with aging have also been significantly increased, especially in order to avoid the reduction of the cognitive abilities in geriatric patients, resulting from the damage generated mainly at the level of the hippocampus during old age. At present, many studies describe resveratrol as an antiaging component. There are reports that it can activate the Sirt1 gene related to antiaging, emulating the effects obtained by caloric restriction in rodents...
2017: Oxidative Medicine and Cellular Longevity
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