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https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#1
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29145715/effect-of-social-support-and-disclosure-of-child-abuse-on-adult-suicidal-ideation-findings-from-a-population-based-study
#2
Philip Baiden, Barbara Fallon, Kofi Antwi-Boasiako
Background: To examine the proportion of Canadian adults with a history of child abuse who disclosed the abuse to child protection services before age 16 years and identify the effect of social support and disclosure of child abuse on lifetime suicidal ideation. Methods: Data for this study came from the Statistics Canada 2012 Canadian Community Health Survey-Mental Health (N = 9,076). Binary logistic regression was conducted to identify the effect of social support and disclosure of child abuse on suicidal ideation while simultaneously adjusting for the effect of type of child abuse and demographic, socioeconomic, health, and mental health factors...
November 16, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29144882/adult-children-of-gay-fathers-parent-child-relationship-quality-and-mental-health
#3
Samantha L Tornello, Charlotte J Patterson
According to family systems theory, parent-child relationships are an important aspect of individual well-being. This study explored associations among parental disclosure, parent-child relationships, and well-being among 84 adult children with gay fathers. We explored associations between the adult children's well-being and the children's ages at sexual orientation disclosure, geographic distance, relationship quality and closeness with their fathers. We found that when parental disclosure had occurred earlier in the adult child's life, participants reported feeling closer to fathers in adulthood...
November 16, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29144068/going-public-early-disclosure-of-food-risks-for-the-benefit-of-public-health
#4
Benjamin Chapman, Maria Sol Erdozaim, Douglas Powell
Often during an outbreak of foodborne illness, there are health officials who have data indicating that there is a risk prior to notifying the public. During the lag period between the first public health signal and some release of public information, there are decision makers who are weighing evidence with the impacts of going public. Multiple agencies and analysts have lamented that there is not a common playbook or decision tree for how public health agencies determine what information to release and when...
March 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29143343/secrets-and-disclosure-in-donor-conception
#5
Lucy Frith, Eric Blyth, Marilyn Crawshaw, Olga van den Akker
This article considers the disclosure, sharing and exchange of information on being donor conceived within families, drawing on data from a study undertaken with donor-conceived adults registered with UK Donor Link (a voluntary DNA-linking register). This paper considers the narratives of how respondents found out they were donor-conceived and what events triggered disclosure of this information. This paper then goes on to examine the role secrecy played in their family life and uses the concept of 'display' to explore how secrecy affected their relationships with their immediate and extended family...
November 16, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29143157/evaluation-of-hiv-disclosure-behavior-following-a-randomized-controlled-disclosure-intervention-for-men-who-have-sex-with-men-living-with-hiv
#6
Julianne M Serovich, Tanja C Laschober, Monique J Brown, Judy A Kimberly
Preventing the transmission of HIV, especially among high-risk populations, is a U.S. public health priority. Interventions aimed at easing the burden of HIV disclosure to casual sexual partners among men who have sex with men (MSM) living with HIV are essential in this endeavor. This randomized controlled study evaluated differences in disclosure behavior between a disclosure intervention (DI) and attention control case management (ACCM) group for MSM living with HIV (N = 315) and determinants (self-efficacy, outcome expectancy) of disclosure...
November 15, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29142538/patient-safety-awareness-among-postgraduate-students-and-nurses-in-a-tertiary-health-care-facility
#7
Attia Bari, Uzma Jabeen, Iqbal Bano, Ahsan Waheed Rathore
Objective: To determine the knowledge of patient safety among postgraduate residents (PGR) and nurses in a tertiary care hospital. Methods: This casual comparative study was conducted among the postgraduate residents and nurses working at The Children's Hospital Lahore in the month of July, August 2017. Both PGR and nurses were asked to complete APSQ-IV questionnaire about patient safety on 7 point Likert scale. Data was analyzed using SPSS version 20 and t-test was used to compare the mean score between two groups...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29140657/sunlight-and-other-disinfectants-disclosure-obligations-under-the-federal-securities-and-drug-regulatory-regimes
#8
Joseph G Milner
Drug development requires patience. Beyond the inherent uncertainty of the development process itself, U.S. drug developers must comply with the regulatory approval process overseen by the U.S. Food and Drug Administration (FDA). Because this process takes time, drug development also costs money. Drug companies seeking to raise funds in U.S. capital markets must navigate the securities regime governed by the Securities & Exchange Commission (SEC). Despite their similar roles as protectors of consumers and public markets, SEC and FDA send conflicting signals about the information drug companies need to disclose to the public...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29140651/fda-required-tobacco-product-inserts-onserts%C3%A2-and-the-first-amendment
#9
Eric N Lindblom, Micah L Berman, James F Thrasher
In 2012, a federal court of appeals struck down an FDA rule requiring graphic health warnings on cigarettes as violating First Amendment commercial speech protections. Tobacco product inserts and onserts can more readily avoid First Amendment constraints while delivering more extensive information to tobacco users, and can work effectively to support and encourage smoking cessation. This paper examines FDA’s authority to require effective inserts and onserts and shows how FDA could design and support them to avoid First Amendment problems...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29138195/current-status-of-postnatal-depression-smartphone-applications-available-on-application-stores-an-information-quality-analysis
#10
Melvyn Wb Zhang, Roger Cm Ho, Alvona Loh, Tracey Wing, Olivia Wynne, Sally Wai Chi Chan, Josip Car, Daniel Shuen Sheng Fung
OBJECTIVES: It is the aim of the current research to identify some common functionalities of postnatal application, and to determine the quality of the information content of postnatal depression application using validated scales that have been applied for applications in other specialties. SETTINGS AND PARTICIPANTS: To determine the information quality of the postnatal depression smartphone applications, the two most widely used smartphone application stores, namely Apple iTunes as well as Google Android Play store, were searched between 20May and 31 May...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29135650/pathways-from-hiv-related-stigma-to-antiretroviral-therapy-measures-in-the-hiv-care-cascade-for-women-living-with-hiv-in-canada
#11
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Tracey Conway, Kath Webster, Alexandra de Pokomandy, Mona R Loutfy
BACKGROUND: Associations between HIV-related stigma and reduced anti-retroviral (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada. METHODS: We utilized baseline survey data from a national cohort of women living with HIV in Canada (n=1425)...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29134431/impact-of-domain-knowledge-on-blinded-predictions-of-binding-energies-by-alchemical-free-energy-calculations
#12
Antonia S J S Mey, Jordi Juárez Jiménez, Julien Michel
The Drug Design Data Resource (D3R) consortium organises blinded challenges to address the latest advances in computational methods for ligand pose prediction, affinity ranking, and free energy calculations. Within the context of the second D3R Grand Challenge several blinded binding free energies predictions were made for two congeneric series of Farsenoid X Receptor (FXR) inhibitors with a semi-automated alchemical free energy calculation workflow featuring FESetup and SOMD software tools. Reasonable performance was observed in retrospective analyses of literature datasets...
November 13, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29134422/hiv-prevention-among-young-women-in-south-africa-understanding-multiple-layers-of-risk
#13
Christina Psaros, Cecilia Milford, Jennifer A Smit, Letitia Greener, Nzwakie Mosery, Lynn T Matthews, Abigail Harrison, Janna R Gordon, Matthew Mimiaga, David R Bangsberg, Steven A Safren
Despite concerted prevention efforts, young South African women remain at the epicenter of the HIV epidemic. Although these women have grown up in a community powerfully affected by HIV, systematic investigation into how this "second generation" of HIV-affected youth navigates HIV risk is lacking. This study qualitatively explored a complex interplay of factors influencing HIV risk among young pregnant women in KwaZulu-Natal, South Africa. We conducted in-depth interviews with 35 pregnant women (22 HIV-uninfected and 13 HIV-infected) aged 18-21, 18 healthcare providers, and focus groups with 19 community stakeholders...
November 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29133064/evaluation-of-abortion-stigma-in-the-workforce-development-of-the-revised-abortion-providers-stigma-scale
#14
Lisa A Martin, Jane A Hassinger, Meghan Seewald, Lisa H Harris
OBJECTIVES: We report on the development of a scale measuring abortion providers' experiences of stigma. STUDY DESIGN: Using previous measures, qualitative data, and expert review, we created a 49-item question pool. We administered questions to 315 abortion providers before participation in the Providers Share Workshop. We explored the factor structure and item quality using exploratory factor analysis. We assessed reliability using Cronbach's alpha. To test construct validity, we calculated Pearson's correlation coefficients between the stigma scales, the Maslach Burnout Inventory, and the K10 measure of psychological distress...
November 10, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29131893/omitted-disclosures-or-potential-conflicts-of-interest
#15
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29130538/-what-if-this-is-my-chance-to-save-my-life-a-semi-structured-interview-study-on-the-motives-and-experiences-of-esrd-patients-who-engaged-in-public-solicitation-of-a-living-kidney-donor
#16
Mathilde C Pronk, Dorthe Slaats, Willij C Zuidema, Medard T Hilhorst, Frank J M F Dor, Michiel Betjes, Willem Weimar, Jacqueline van de Wetering, Emma K Massey
The increase of patients using public solicitation (PS) to find a living kidney donor has generated a debate about the ethical complexities of PS. To investigate why patients engaged in PS and what they experienced during PS we conducted semi-structured interviews with 20 Dutch end-stage renal disease patients who had publicly solicited a living donor. Transcipts were thematically analyzed. We identified ten themes on patients' considerations preceding PS: cautiousness in discussing living donation within social network; reluctance to accept a kidney from loved ones; rejection/withdrawal of related donor candidates; moral objections to black market organs/paid donation; the ease of social media; encouraged by others; ends justyfying the means; despair and urge to take action; public disclosure of vulnerability; fear of being (perceived to be) selfish...
November 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29130333/non-disclosure-to-male-partners-and-incomplete-pmtct-regimens-associated-with-higher-risk-of-mother-to-child-hiv-transmission-a-national-survey-in-kenya
#17
Christine J McGrath, Benson Singa, Agnes Langat, John Kinuthia, Keshet Ronen, Danvers Omolo, Benjamin Elly Odongo, Rose Wafula, Prisca Muange, Abraham Katana, Lucy Ng'anga', Grace C John-Stewart
Health worker experience and community support may be higher in high HIV prevalence regions than low prevalence regions, leading to improved prevention of mother-to-child HIV transmission (PMTCT) programs. We evaluated 6-week and 9-month infant HIV transmission risk (TR) in a high prevalence region and nationally. Population-proportionate-to-size sampling was used to select 141 clinics in Kenya, and mobile teams surveyed mother-infant pairs attending 6-week and 9-month immunizations. HIV DNA testing was performed on HIV-exposed infants...
November 11, 2017: AIDS Care
https://www.readbyqxmd.com/read/29127696/inspiring-hope-a-physician-s-responsibility-translating-the-science-into-clinical-practice
#18
REVIEW
Walley J Temple
Giving hope to patients is our responsibility. It is the essence of a meaningful practice in medicine. Science now allows us to understand this complex and multidimensional human dynamic, and translate it into clinical practice. Quantitative research has shown hope is strong even in terminal illness. Through qualitative methodology hope fostering strategies and hope hindering behaviors have been identified. This exciting new knowledge facilitates the challenging task of disclosure of bad news while enabling hope...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29127257/disclosure-of-genetic-information-to-relatives-balancing-confidentiality-and-relatives-interests
#19
EDITORIAL
Anneke Lucassen, Roy Gilbar
No abstract text is available yet for this article.
November 10, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29126916/how-well-are-u-s-primary-care-providers-assessing-whether-their-male-patients-have-male-sex-partners
#20
Pollyanna R G Chávez, Laura G Wesolowski, Philip J Peters, Christopher H Johnson, Muazzam Nasrullah, Emeka Oraka, Euna M August, Elizabeth DiNenno
Identifying patients at-risk for HIV infection, such as men who have sex with men (MSM), is an important step in providing HIV testing and prevention interventions. It is unknown how primary care providers (PCPs) assess MSM status and related HIV-risk factors. We analyzed data from a panel-derived web-based survey for healthcare providers conducted in 2014 to describe how PCPs in the U.S. determined their patients' MSM status. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) to describe PCP characteristics associated with systematically determining MSM status (i...
November 7, 2017: Preventive Medicine
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