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Elif Guler, Nilgun Col, Mithat Buyukcelik, Ayse Balat
AIM: In recent years, survival rates of childhood cancers have significantly increased, and occurrence of long-term adverse late effects (eg, insulin resistance, diabetes mellitus, metabolic syndrome, hypertension) has become increasingly important. Early diagnosis of obesity/hypertension in childhood is essential to avoid morbidity in the adulthood. Therefore, this study was aimed to determine the blood pressure (BP) profile by ambulatory BP monitoring (ABPM) method, and prevalence of hypertension, obesity, abdominal obesity among childhood cancer survivors...
March 12, 2018: Pediatric Hematology and Oncology
Antonio R Porras, Beatriz Paniagua, Andinet Enquobahrie, Scott Ensel, Hina Shah, Robert Keating, Gary F Rogers, Marius George Linguraru
The outcome of cranial vault reconstruction for the surgical treatment of craniosynostosis heavily depends on the surgeon's expertise because of the lack of an objective target shape. We introduce a surface-based diffeomorphic registration framework to create the optimal post-surgical cranial shape during craniosynostosis treatment. Our framework estimates and labels where each bone piece needs to be cut using a reference template. Then, it calculates how much each bone piece needs to be translated and in which direction, using the closest normal shape from a multi-atlas as a reference...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Anzu Yamamoto, Takuya Omotehara, Yuuka Miura, Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Youhei Mantani, Hiroshi Kitagawa, Toshifumi Yokoyama, Nobuhiko Hoshi
Anti-Müllerian hormone (AMH) produced in the developing testis induces the regression of the Müllerian duct, which develops into the oviducts, uterus and upper vagina. In our true hermaphrodite mouse with an ovary on one side and a testis on the other (O/T), the oviduct and uterus are present only on the ovary side, and nothing derived from the Müllerian duct is present on the testis side. Here, we investigate the mechanism underlying the unilateral Müllerian duct regression and the mode of AMH signaling, by performing immunohistology, Western blotting, and organ culture analyses...
March 9, 2018: Journal of Veterinary Medical Science
Chi Hoon Maeng, Jae-Uk Song, Sung Ryul Shim, Jonghoo Lee
INTRODUCTION: The role of prophylactic cranial irradiation (PCI) is controversial in patients with extensive stage small cell lung cancer (ES-SCLC). The aim of this study was to determine the impact of PCI in these patients. METHODS: We performed a systematic review and meta-analysis in accordance with PRISMA guidelines. A systematic literature search was conducted in MEDLINE, EMBASE, and the Cochrane Central Register. The primary outcome was overall survival (OS)...
March 8, 2018: Journal of Thoracic Oncology
S Bastaninejad, E Karimi, N Saeedi, E Amirizad
Despite progress made in nasal reconstruction, the restoration of a large defect, including the whole septum and mid-nasal vault structures, remains a challenge. The pericranial flap (PCF) is used widely for the reconstruction of anterior cranial fossa defects. This article presents a surgical technique for nasal lining restoration with an endoscopic PCF design. This technique was used in patients with huge intranasal tumours. Two patients with nasal eosinophilic angiocentric fibrosis were treated. The structural involvement was similar in each case...
March 8, 2018: International Journal of Oral and Maxillofacial Surgery
Tamás Bodzay, Gergely Sztrinkai, András Kocsis, Báliinstnt Kozma, Tamás Gál, Károly Váradi
OBJECTIVES: This study aims to investigate if the stabilization of iliac wing fractures influences the stability of the acetabular osteosynthesis, if surgical fixation is the choice of treatment, and which technique to be used. MATERIALS AND METHODS: In the study, measurements were performed with an improved finite element model. Tension and displacement values were measured in bicolumnar acetabular fractures in the following cases: combination of cranial and medial plate fixation through the linea terminalis, or combination of cranial plate and quadrilateral surface plates...
April 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
Katherine E Weisensee, M Katherine Spradley
This study examines levels of fluctuating asymmetry (FA) in Mexican residents, U.S. residents, and undocumented border crossers (UBCs) from Mexico to the United States. Craniofacial structures develop symmetrically under ideal circumstances; however, during periods of developmental stress random deviations from perfect symmetry, or FA, can occur. It is hypothesized that the UBC sample would represent individuals of a lower socioeconomic status (SES) who experienced higher stress levels during development, and that these individuals would consequently have higher levels of FA...
February 24, 2018: Economics and Human Biology
Hidehiro Yamamoto, Masayoshi Okada
OBJECTIVE: Endoscopic thoracic sympathectomy at the second rib level is considered effective as a therapeutic treatment for facial blushing. However, 10% to 15% of patients do not benefit from this intervention. No additional procedure has been developed for this disorder. Recently, ganglionectomy using application of laser speckle flow graph has been evaluated for the treatment of compensatory sweating. We report our results of ganglionectomy for facial blushing as a redo surgery. METHODS: Between August 2012 and April 2017, 8 patients with facial blushing who underwent an initial sympathectomy reported symptom recurrence...
February 13, 2018: Journal of Thoracic and Cardiovascular Surgery
Gina E Bertocci, Nathan P Brown, Patrice M Mich
The objective of this study was to describe the patient population of dogs with cranial cruciate ligament (CrCL) deficiency that were prescribed a stifle orthosis. A total of 215 client-owned dogs with previously diagnosed CrCL deficiency were prescribed a stifle orthosis at a veterinary pain management and mobility clinic. Patient intake data collected included dog signalment, chief medical complaint, home environment and activity description, medical and surgical history, and diagnosing veterinarian. An orthopedic examination was conducted to assess pelvic limb function and determine pelvic limb morphologic measures...
December 2017: Topics in Companion Animal Medicine
Qing Wang, Xinjie Wu, Mingsheng Tan, Gaoju Wang, Shuang Xu, Yingna Qi
OBJECTIVE: To describe lower cranial nerve palsy (LCNP) following vertical over-distraction when performing occipitocervical fusion (OCF) to treat vertical atlantoaxial dislocation (AAD) and basilar invagination (BI) and to investigate its possible causes. METHODS: We report 4 cases with vertical AAD and BI who postoperatively presented with neurogenic dysphagia, dysarthria, and bucking after undergoing anatomical reduction. RESULTS: Patients underwent revision surgery to achieve partial reduction and demonstrated remarkable recovery of 9th , 10th and 11th nerve deficits...
March 7, 2018: World Neurosurgery
Ileana Iftimia, Per H Halvorsen
PURPOSE: The aim of this study was to develop Quality Assurance procedures for the BrainLab ExacTrac (ET) imaging system following the TG 142 recommendations for planar kV imaging systems. MATERIALS AND METHODS: A custom-designed 3D printed holder was used to position the Standard Imaging QCkV-1 phantom at isocenter, facing the ET X ray tubes. The linac's light field (collimator at 45⁰) was used to position the phantom holder. The ET images were exported to ARIA where geometric distortion was checked...
March 10, 2018: Journal of Applied Clinical Medical Physics
Srdjan Cirovic, Robert Lloyd, Jelena Jovanovik, Holger A Volk, Clare Rusbridge
BACKGROUND: Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiari malformation, which is similar in both humans and animals. Some brachycephalic toy breed dogs such as Cavalier King Charles Spaniels (CKCS) are particularly predisposed. The exact mechanism of the formation of syringomyelia is undetermined and consequently with the lack of clinical explanation, engineers and mathematicians have resorted to computer models to identify possible physical mechanisms that can lead to syringes...
March 9, 2018: BMC Veterinary Research
Iris Ribitsch, Christian Peham, Nicole Ade, Julia Dürr, Stephan Handschuh, Johannes Peter Schramel, Claus Vogl, Heike Walles, Monika Egerbacher, Florien Jenner
Meniscal pathologies are among the most common injuries of the femorotibial joint in both human and equine patients. Pathological forces and ensuing injuries of the cranial horn of the equine medial meniscus are considered analogous to those observed in the human posterior medial horn. Biomechanical properties of human menisci are site- and depth- specific. However, the influence of equine meniscus topography and composition on its biomechanical properties is yet unknown. A better understanding of equine meniscus composition and biomechanics could advance not only veterinary therapies for meniscus degeneration or injuries, but also further substantiate the horse as suitable translational animal model for (human) meniscus tissue engineering...
2018: PloS One
Joost M Costerus, Matthijs C Brouwer, Marieke E S Sprengers, Stefan D Roosendaal, Arie van der Ende, Diederik van de Beek
Background: It is unclear how often lumbar puncture (LP) is complicated by cerebral herniation in patients with bacterial meningitis and whether cranial CT can be used to identify patients at risk for herniation. Methods: We performed a nationwide prospective cohort study of patients with community-acquired bacterial meningitis from 2006 to 2014 and identified patients with clinical deterioration possibly caused by LP. For systematic evaluation of contraindications for LP on cranial CT, these patients were matched to patients in the cohort without deterioration...
March 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Netanja S Ter Maaten, Daniel M Mazzaferro, Ari M Wes, Sanjay Naran, Scott P Bartlett, Jesse A Taylor
BACKGROUND: Posterior vault distraction osteogenesis (PVDO) is believed to improve frontal contour in infants with syndromic craniosynostosis and turribrachycephaly. This study provides an objective craniometric analysis to determine how PVDO affects anterior cranial morphology. METHODS: A retrospective chart review of patients who underwent PVDO was performed. Inclusion criteria included pre- and postoperative computed tomography (CT) scans within 3 months before surgery and another 1 to 6 months after device removal...
March 8, 2018: Journal of Craniofacial Surgery
Pedro Martinez-Seijas, Luis A Díaz-Galvis, Josué Hernando, Ignacio O Leizaola-Cardesa, Antonio Aguilar-Salvatierra, Gerardo Gómez-Moreno
BACKGROUND: Over the years, many materials have been used in orbital reconstruction and cranioplasty. Among the materials in current use, polymethyl methacrylate (PMMA) offers a high degree of compatibility with human tissue. OBJECTIVE: This work describes a new, custom-made, 3D printing-aided, prosthetic fabrication process for orbital and/or cranial reconstruction using PMMA. METHODS: On the basis of information obtained from computerized tomography scanning processed in Digital Imaging and Communication in Medicine format and exported to treatment planning software, a 3D prosthesis master model was designed and digitally printed...
March 8, 2018: Journal of Craniofacial Surgery
Jéssica Araújo Figueira, Fábio Roberto de Souza Batista, Karina Rosso, Vanessa Cristina Veltrini, Angelo José Pavan
Gorlin-Goltz syndrome (GGS), also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder with high penetrance and variable expressivity. The classic triad originally described by Gorlin and Goltz in 1960 is composed of multiple nevoid basal cell carcinomas (NBCCs), odontogenic keratocysts (OKCs) in the jaws and bifid ribs. in 1977, this triad was modified by Rayner et al, and to GGS diagnosis, the OKCs had to appear in combination with calcification of the cerebellar falx or palmar and plantar pits...
March 8, 2018: Journal of Craniofacial Surgery
Rosalinda Calandrelli, Fabio Pilato, Luca Massimi, Marco Panfili, Gabriella D'Apolito, Simona Gaudino, Cesare Colosimo
PURPOSE: Craniosynostostic syndromes are due to multisuture synostoses and affect the entire craniofacial skeleton. This study analyzed the facial complex and airways to quantify the relationship between insufficient facial growth, airways obstruction, and the sutural pattern of the splanchnocranium and cranial fossae. METHODS: Preoperative high-resolution CT images in 19 infants with syndromic craniosynostosis were quantitatively analyzed. Because all children showed involvement of minor sutures/synchondroses coursing in the posterior cranial fossa, they were divided into three groups according to the synostotic involvement of "minor" sutures/synchondroses coursing in anterior (ACF) and middle (MCF) cranial fossae: group 1 (ACF), group 2 (MCF), and group 3 (ACF-MCF)...
March 8, 2018: Neuroradiology
Teresa Matthews-Brzozowska, Dorota Hojan-Jezierska, Wawrzyniec Loba, Marta Worona, Artur Matthews-Brzozowski
A review of numerous case reports was made, in order to demonstrate the possibilities for treatment of dental disorders in patients with Cleidocranial dysplasia (CCD). In this paper, our own report, including a diagnosis of the effect on the auditory system, is presented. In addition to the triad of CCD symptoms that include hypoplastic or aplastic clavicles, impacted and supernumerary teeth, delayed closure of fontanelles and cranial sutures, impairment of the hearing system resulting in conductive hearing loss also occurs...
2018: Open Medicine (Warsaw, Poland)
Jong Kook Rhim, Young Dae Cho, Dong Hyun Yoo, Hyun-Seung Kang, Won-Sang Cho, Jeong Eun Kim, Min Jae Cho, Gyojun Hwang, O-Ki Kwon, Moon Hee Han
Objective: Bilateral cavernous sinus dural arteriovenous fistula (CSdAVF) is very rare, even in Asian countries. The research intended to present clinical and radiologic outcomes of treating such fistulas through endovascular embolization. Materials and Methods: Data was obtained from 220 consecutive patients, with CSdAVF, who were treated from January 2004 to December 2015. Bilateral CSdAVF was identified in 17 patients (7.7%). The clinical and radiologic outcomes of the fistulas were assessed with an emphasis on the technical aspects of treatment...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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