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Michelle L Pickett, Marlene D Melzer-Lange, Melissa K Miller, Seema Menon, Alexis M Vistocky, Amy L Drendel
OBJECTIVES: There is limited literature about physicians' adherence to 2010 Centers for Disease Control and Prevention (CDC) Sexually Transmitted Diseases Treatment Guidelines specific to specimen collection testing methods in adolescent females in the emergency setting is limited. The objectives are to (1) determine physician adherence to CDC guidelines for specimen collection/testing for chlamydia and gonorrhea, (2) determine physician characteristics associated with guideline adherence, and (3) describe physicians' knowledge of expedited partner therapy (EPT) laws...
October 4, 2016: Pediatric Emergency Care
Manju Bala, Vikram Singh, Aradhana Bhargava, Monika Kakran, Naveen Chandra Joshi, Ravi Bhatnagar
Antimicrobial susceptibility testing of 258 N. gonorrhoeae isolates by Etest determined that 60.1% were MDR while 5% strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% MDR and 76.9% strains having decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea...
October 10, 2016: Antimicrobial Agents and Chemotherapy
Andrej Weintraub, Mamun-Ur Rashid, Carl Erik Nord
Solithromycin is a novel fluoroketolide with high activity against bacteria associated with community-acquired respiratory tract infections as well as gonorrhea. However, data on the activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota are scarce. In this study, 1024 Gram-positive and Gram-negative anaerobic isolates from the normal intestinal microbiota were analyzed for in-vitro susceptibility against solithromycin and compared to azithromycin, amoxicillin/clavulanic acid, ceftriaxone, metronidazole and levofloxacin by determining the minimum inhibitory concentration (MIC)...
October 7, 2016: Anaerobe
Tucker Harrison, Mo Som, Jeff Stroup
We describe a 60-year-old man who presented with rectal pain and bleeding of a month's duration. His presentation was highly suggestive of lymphogranuloma venereum (LGV) proctitis. Nucleic acid amplification for chlamydia and gonorrhea via rectal swab revealed evidence supportive of anorectal chlamydia. Treatment with doxycycline resulted in complete resolution of his symptoms.
October 2016: Proceedings of the Baylor University Medical Center
R-E Klingenberg, S Mannherz, N H Brockmeyer, J Wach, R Winter, C Tiemann, A Lucht, S Schaffer, M Eickel, A Skaletz-Rorowski
BACKGROUND: Inadequate access to prevention and medical treatment for female sex workers (SW) represents a challenge for the German health system. Accessibility and care for SW in Bochum (Germany) through a cooperation between the Interdisciplinary Immunology Outpatient Clinic, Center for Sexual Health and Medicine of St. Josef's Hospital, the Bochum health department and the Madonna e.V. was the focus of this work. PATIENTS AND METHODS: Medical outreach services were provided for the diagnosis of sexually transmitted infections (STI) in SW in brothels in Bochum between August 2013 and January 2014...
September 29, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Enesia Banda Chaponda, R Matthew Chico, Jane Bruce, Charles Michelo, Bellington Vwalika, Sungano Mharakurwa, Mike Chaponda, James Chipeta, Daniel Chandramohan
Malarial infection and curable sexually transmitted and reproductive tract infections (STIs/RTIs) are important causes of adverse birth outcomes. Reducing the burden of these infections in pregnancy requires interventions that can be easily integrated into the antenatal care (ANC) package. However, efforts to integrate the control of malarial infection and curable STIs/RTIs in pregnancy have been hampered by a lack of evidence related to their coinfection. Thus, we investigated the prevalence of coinfection among pregnant women of rural Zambia...
September 26, 2016: American Journal of Tropical Medicine and Hygiene
Phillip Marotta
Sexually transmitted infections (STIs) remain serious public health problems particularly in urban environments in the USA. Despite accumulating research into the role of aggregate rates of crime in shaping rates of STIs, few studies account for spatial dependence in the structure of geographical data. Using multiple spatial analysis methodologies, the following study investigated spatial patterns in community area rates of violent, drug, and property crimes and rates of infection of gonorrhea and chlamydia in 77 community areas in Chicago...
September 26, 2016: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Susan M Kiene, Haruna Lule, Peter Hughes, Rhoda K Wanyenze
Numerous HIV risk reduction interventions which show effects on sexual risk behaviors fail to find effects on STIs. We examined the concordance between laboratory diagnosed STIs and sexual risk behavior among Ugandan outpatients (n = 328). We screened for STIs and assessed sexual behavior at baseline and 6 month follow-up. Less risk was associated with an STI at baseline. At follow-up more unprotected sex with casual partners was associated with incident Syphilis, more unprotected sex with primary and secondary regular partners was associated with incident Chlamydia or Gonorrhea...
September 24, 2016: AIDS and Behavior
Elia Gabarron, Rolf Wynn
BACKGROUND: In order to prevent sexually transmitted infections (STIs), the World Health Organization recommends educating people on sexual health. With more than 2 billion active users worldwide, online social media potentially represent powerful channels for health promotion, including sexual health. OBJECTIVE: To review the scientific literature on the use of online social media for sexual health promotion. DESIGN: A search was conducted of scientific and medical databases, and grey literature was also included...
2016: Global Health Action
Yonatan H Grad, Simon R Harris, Robert D Kirkcaldy, Anna G Green, Debora S Marks, Stephen D Bentley, David Trees, Marc Lipsitch
BACKGROUND:  Treatment of Neisseria gonorrhoeae infection is empiric and based on population-wide susceptibilities. Increasing antimicrobial resistance underscores the potential importance of rapid diagnostics, including sequence-based tests, to guide therapy. However, the utility of sequence-based diagnostics depends on the prevalence and dynamics of the resistance mechanisms. METHODS:  We define the prevalence and dynamics of resistance markers to extended spectrum cephalosporins (ESC), macrolides, and fluoroquinolones in 1102 resistant and susceptible clinical N...
September 16, 2016: Journal of Infectious Diseases
I Putu Yuda Hananta, Alje P van Dam, Sylvia Maria Bruisten, Maarten Franciscus Schim van der Loeff, Hardyanto Soebono, Henry John Christiaan de Vries
BACKGROUND: Little is known about the epidemiology of asymptomatic urogenital gonorrhea and antimicrobial susceptibility of Neisseria gonorrhoeae (NG) strains circulating in Indonesia. We studied these issues in 3 large Indonesian cities. METHODS: In 2014, participants were recruited from sexually transmitted infection clinics and through outreach in Jakarta, Yogyakarta, and Denpasar. Neisseria gonorrhoeae detection in genital specimens was performed with NG-qPCR at the Public Health Service in Amsterdam...
October 2016: Sexually Transmitted Diseases
Seada Ali, Tsegaye Sewunet, Zewdineh Sahlemariam, Gebre Kibru
BACKGROUND: Neisseria gonorrhoeae is a bacterium responsible for one of the classic sexually transmitted infection (STI) gonorrhea. Antibiotic resistant strains are emerging at alarming rate. Multiple sexual partners, unsafe sex and substance use habits are the main host related risk factors for acquiring the infection. Thus, this study aimed at determining the magnitude, its determinants and antimicrobial resistance profile of N. gonorrhoeae in a place where there is risk related cultural practices and relatively high HIV prevalence...
2016: BMC Research Notes
Ravi Jain, Subash C Sonkar, Uma Chaudhry, Manju Bala, Daman Saluja
OBJECTIVES: Resistance to the currently recommended extended-spectrum cephalosporins, which is used to treat Gonorrhea, is increasing continuously and leading to a threat of untreatable infection. It is, therefore, becoming extremely essential to search for new therapeutic strategies to control Gonorrhea. Vaccination may be considered as an effective control measure to control this disease, which is caused by Neisseria gonorrhoeae. METHODS: In-silico hierarchical approach was used to help identify candidate proteins of N...
September 3, 2016: Journal of Theoretical Biology
Joanna Watson, Jerry Carlile, Angela Dunn, Megan Evans, Erin Fratto, Joel Hartsell, Lynn Meinor, Matthew Mietchen, Allyn Nakashima
Gonorrhea (caused by infection with Neisseria gonorrhoeae) is the second most commonly reported notifiable disease in the United States (1). Left untreated, gonorrhea is associated with serious long-term adverse health effects, including pelvic inflammatory disease, ectopic pregnancy, and infertility. Infection also facilitates transmission of human immunodeficiency virus (2,3). Effective gonorrhea control relies upon early detection and effective antimicrobial treatment. To assess gonorrhea rate trends in Utah, the Utah Department of Health (UDOH) analyzed Utah National Electronic Disease Surveillance System (UT-NEDSS) data for the state during 2009-2014...
2016: MMWR. Morbidity and Mortality Weekly Report
Nada A Abdelrahim, Hiba I Ahmed, Imad M Fadl-Elmula, Magdi A Bayoumi, Mamoun M Homeida
Sexually transmitted infections (STIs) are major health threats affecting people globally; however, the burden of STIs is greatest in low-income countries. Since they are physiologically more vulnerable, women are mostly affected. The risk is increased dramatically during pregnancy leading to serious health complications that may affect the newborn. Underprivileged pregnant women attending antenatal clinics for routine checkups in displaced camps, a women's prison and several peripheral health centres were clinically and laboratory screened for trichomoniasis, chlamydial infections, gonorrhea and syphilis...
August 31, 2016: International Journal of STD & AIDS
Manik Ghosh, Andrea Civra, Massimo Rittà, Valeria Cagno, Siva Ganesh Mavuduru, Preeti Awasthi, David Lembo, Manuela Donalisio
Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity...
December 2016: Archives of Virology
Geik Yong Ang, Choo Yee Yu, Delicia Ann Yong, Yuet Meng Cheong, Wai-Fong Yin, Kok-Gan Chan
Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae and the increasing reports of multidrug-resistant gonococcal isolates are a global public health care concern. Herein, we report the genome sequence of N. gonorrhoeae strain NG_869 isolated from Malaysia which may provide insights into the drug resistance determinants in gonococcal bacteria.
June 2016: Indian Journal of Microbiology
Oluwatoyosi A Adekeye, Winston E Abara, Junjun Xu, Joel M Lee, George Rust, David Satcher
INTRODUCTION: Approximately 20 million new sexually transmitted infections (STIs) are diagnosed yearly in the United States costing the healthcare system an estimated $16 billion in direct medical expenses. The presence of other STIs increases the risk of HIV transmission. The Centers for Disease Control and Prevention (CDC) has long recommended routine HIV screening for individuals with a diagnosed STI. Unfortunately, HIV screening prevalence among STI diagnosed patients are still sub-optimal in many healthcare settings...
2016: PloS One
Jaqueline L Damasceno, Pollyanna F Oliveira, Mariza A Miranda, Luis F Leandro, Nathália O Acésio, Saulo D Ozelin, Jairo K Bastos, Denise C Tavares
Solanum cernuum Vell is a Brazilian shrub or small tree, restricted to Southeast states of the country. The leaves are commercialized as "panacéia" and indicated for the treatment of urinary disorders, gonorrhea, scabies, skin diseases and as desobstruent, diuretic and antiarrhythmic. The hydroalcholic extract is active in the treatment of gastric ulcer. The aim of this study was to evaluate the genotoxic and antigenotoxic potential of S. cernuum hydroalcoholic extract (SC) in Swiss mice by micronucleus and comet assays...
August 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jia Mun Chan, Joseph P Dillard
: Neisseria gonorrhoeae (gonococci) and Neisseria meningitidis (meningococci) are human pathogens that cause gonorrhea and meningococcal meningitis, respectively. Both N. gonorrhoeae and N. meningitidis release a number of small peptidoglycan (PG) fragments, including proinflammatory PG monomers, although N. meningitidis releases fewer PG monomers. The PG fragments released by N. gonorrhoeae and N. meningitidis are generated in the periplasm during cell wall remodeling, and a majority of these fragments are transported into the cytoplasm by an inner membrane permease, AmpG; however, a portion of the PG fragments are released into the extracellular environment through unknown mechanisms...
November 1, 2016: Journal of Bacteriology
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