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https://www.readbyqxmd.com/read/28210887/drug-resistant-neisseria-gonorrhoeae-latest-developments
#1
REVIEW
B Suay-García, M T Pérez-Gracia
Gonorrhea is the second most frequently reported notifiable disease in the United States and is becoming increasingly common in Europe. The purpose of this review was to assess the current state of drug-resistant Neisseria gonorrhoeae in order to evaluate future prospects for its treatment. An exhaustive literature search was conducted to include the latest research regarding drug resistance and treatment guidelines for gonorrhea. Gonococci have acquired all known resistance mechanisms to all antimicrobials used for treatment...
February 16, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28182592/transmission-behaviors-and-prevalence-of-chlamydia-and-gonorrhea-among-adult-film-performers
#2
Marjan Javanbakht, M Claire Dillavou, Robert W Rigg, Peter R Kerndt, Pamina M Gorbach
BACKGROUND: Adult film work involves multiple sex partners, unprotected intercourse and frequent oral/rectal contact. Data on sexual networks and sexual behaviors of adult film performers (AFP) are limited. METHODS: From August 2012 to May 2013, AFPs in Los Angeles, CA, seeking care at 2 clinics that provide sexually transmitted infections (STIs) testing to performers were offered urogenital, pharyngeal, and rectal chlamydia/gonorrhea testing. Participants were 18 years or older and performed in at least 1 adult film scene within the past year...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178743/-antibiotics-in-which-fields-is-there-need-for-action
#3
Hendrik Sauskojus, Christian Wagner-Ahlfs, Oliver Razum
For decades, antibiotics have been utilized successfully to treat infectious diseases. As part of a natural process, resistance mechanisms evolved in bacteria rendering some of these antibiotics ineffective. A significant increase in the use of antibiotics worldwide has greatly accelerated this process. As a result, treatment of many infectious diseases such as tuberculosis or gonorrhea has become increasingly difficult and nosocomial infections are causing great problems in health care systems. Many action plans and counter-measures have been developed but are seldom put into action and fail to address all problems related to antibiotic resistance...
February 8, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#4
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178112/antimicrobial-susceptibility-of-neisseria-gonorrhoeae-in-japan-from-2000-to-2015
#5
Mitsuru Yasuda, Kyoko Hatazaki, Shin Ito, Masataka Kitanohara, Mutsumasa Yoh, Munekado Kojima, Harunori Narita, Akira Kido, Kazutoyo Miyata, Takashi Deguch
BACKGROUND: Gonococcal infections are difficult to treat because of their multidrug antimicrobial resistance. The outbreak of antimicrobial-resistant Neisseria gonorrhoeae has begun in Asia and particularly in Japan. Therefore, it is very important that we understand the trend of antimicrobial resistance of N. gonorrhoeae in Asia including Japan. Our surveillance of the antimicrobial susceptibility of N. gonorrhoeae began in 2000 under the guidance of the Department of Urology, Gifu University...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178109/risk-factors-for-incidence-of-sexually-transmitted-infections-among-women-in-a-human-immunodeficiency-virus-chemoprevention-trial-voice-mtn-003
#6
Zvavahera Mike Chirenje, Holly M Gundacker, Barbra Richardson, Lorna Rabe, Zakir Gaffoor, Gonasagrie Lulu Nair, Brenda Gati Mirembe, Jeanna M Piper, Sharon Hillier, Jeanne Marrazzo
BACKGROUND: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial. METHODS: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28129372/costing-of-national-sti-program-implementation-for-the-global-sti-control-strategy-for-the-health-sector-2016-2021
#7
Eline L Korenromp, Teodora Wi, Stephen Resch, John Stover, Nathalie Broutet
INTRODUCTION: In 2016 the World Health Assembly adopted the global strategy on Sexually Transmitted Infections (STI) 2016-2021 aiming to reduce curable STIs by 90% by 2030. We costed scaling-up priority interventions to coverage targets. METHODS: Strategy-targeted declines in Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum and Trichomonas vaginalis were applied to WHO-estimated regional burdens at 2012. Syndromic case management was costed for these curable STIs, symptomatic Herpes Simplex Virus 2 (HSV-2), and non-STI vaginal syndromes, with incrementally expanding etiologic diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28125569/prevalence-of-pelvic-inflammatory-disease-in-sexually-experienced-women-of-reproductive-age-united-states-2013-2014
#8
Kristen Kreisel, Elizabeth Torrone, Kyle Bernstein, Jaeyoung Hong, Rachel Gorwitz
Pelvic inflammatory disease (PID) is a clinical syndrome of the female reproductive tract characterized by inflammation of the endometrium, fallopian tubes, or peritoneum (1). PID occurs when microorganisms ascend from the vagina or cervix to the fallopian tubes and other upper genital tract structures (1). PID can result from untreated bacterial infections, including chlamydia and gonorrhea, and can lead to infertility, ectopic pregnancy, and chronic pelvic pain (1). Because there is no single diagnostic test for PID, clinicians rely on nonspecific signs and symptoms for diagnosis...
January 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28114964/antinociceptive-effect-of-methanol-extract-of-dalbergia-sissoo-leaves-in-mice
#9
Md Abdul Mannan, Ambia Khatun, Md Farhad Hossen Khan
BACKGROUND: Dalbergia sissoo DC. (Family: Fabaceae) is a medium to large deciduous tree, is locally called "shishu" in Bangladesh. It is used to treat sore throats, dysentery, syphilis, bronchitis, inflammations, infections, hernia, skin diseases, and gonorrhea. This study evaluated the antinociceptive effect of the methanol extract of D. sissoo leaves (MEDS) in mice. METHODS: The extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p...
January 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28114879/prevalence-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-an-urban-public-hospital-pregnancy-termination-clinic
#10
JeeYoon Park, Lindsay Zimmerman, Kelly Stempinski, Rebecca Bridge, Alicia Roston, Ashlesha Patel
This study is a follow-up observational study to assess the prevalence of chlamydia (CT) and gonorrhea (GC) among women who undergo a first-trimester surgical termination in a large public, urban hospital-based termination clinic, and to compare the rates to previously published data. We conducted a retrospective chart review on 4197 patients who underwent CT and GC testing before an elective, first-trimester surgical termination between 1 June 2014 and 31 May 2015. The prevalence rates were calculated and compared by chi square tests to previously published data from 1 January 2006 to 30 June 2006 from the same publicly-funded pregnancy termination clinic...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28108382/new-xanthones-and-cytotoxic-constituents-from-garcinia-mangostana-fruit-hulls-against-human-hepatocellular-breast-and-colorectal-cancer-cell-lines
#11
Gamal A Mohamed, Ahmed M Al-Abd, Ali M El-Halawany, Hossam M Abdallah, Sabrin R M Ibrahim
ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28103834/depression-alcohol-use-and-intimate-partner-violence-among-outpatients-in-rural-uganda-vulnerabilities-for-hiv-stis-and-high-risk-sexual-behavior
#12
Susan M Kiene, Haruna Lule, Katelyn M Sileo, Kazi Priyanka Silmi, Rhoda K Wanyenze
BACKGROUND: Intimate partner violence (IPV), alcohol use, and depression are key vulnerabilities for HIV in Uganda, and taken together may have a synergistic effect on risk. Our objective was to investigate the associations between depression, IPV, and alcohol use and HIV-risk indicators among a sample of outpatients in rural Uganda, and the effect of co-occurrence of these factors on HIV-risk indicators. METHODS: In a structured interview we collected data on high-risk sexual behavior, depression symptoms, emotional and physical IPV, and alcohol use, as well as a blood sample for HIV and syphilis tests and a urine sample for chlamydia and gonorrhea tests from 325 male and female outpatients receiving provider-initiated HIV testing and counseling (PITC) at a public hospital outpatient clinic in rural Uganda...
January 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28098545/increase-in-urgent-care-center-visits-for-sexually-transmitted-infections-united-states-2010-2014
#13
William S Pearson, Guoyu Tao, Karen Kroeger, Thomas A Peterman
During 2010-2014, urgent care centers saw a ≈2-fold increase in the number of visits for chlamydia and gonorrhea testing and a >3-fold increase in visits by persons with diagnosed sexually transmitted infections. As urgent care becomes more popular, vigilance is required to ensure proper management of these diseases.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28094065/risk-factors-for-antimicrobial-resistant-neisseria-gonorrhoeae-and-characteristics-of-patients-infected-with-gonorrhea
#14
Irene Fuertes de Vega, Carola Baliu-Piqué, Jordi Bosch Mestres, Andrea Vergara Gómez, Xavier Vallés, Mercè Alsina Gibert
BACKGROUND: There are very few data available regarding risk factors associated with antibiotic resistant-Neisseria gonorrhoeae. METHODS: A study was conducted on 110 samples from 101 patients with gonococcal infection, in order to describe their characteristics and compare them with the antimicrobial susceptibility profile of their samples. RESULTS: An association was observed between resistant infections and heterosexual men, older age, concurrent sexually transmitted infection, and unsafe sexual behaviors...
January 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28081044/evaluation-of-the-condom-barriers-scale-for-young-black-men-who-have-sex-with-men-reliability-and-validity-of-3-subscales
#15
Richard A Crosby, Stephanie A Sanders, Cynthia A Graham, Robin Milhausen, William L Yarber, Leandro Mena
BACKGROUND: Reliable and valid scale measures of barriers to condom use are not available for young black men who have sex with men (YBMSM). The purpose of this study was to evaluate the Condom Barriers Scales for application with YBMSM. METHODS: A clinic-based sample of 600 YBMSM completed a computer-assisted self-interview. The primary measure was a 14-item abbreviated version of the Condom Barriers Scale. Reliability and criterion validity were assessed. RESULTS: All 3 subscales were reliable: partner-related barriers (Cronbach α=0...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28079747/how-reliable-is-microscopy-and-culture-for-the-diagnosis-of-gonorrhea-an-11-year-experience-from-india
#16
Aradhana Bhargava, Manju Bala, Vikram Singh, Naveen Chandra Joshi, Monika Kakran, Poonam Puri, Niti Khunger, Venkatesh Ramesh, Ashok Kumar Saxena
Positivity of microscopy and culture was greater (P < 0.0001) in men with urethral discharge syndrome (65.8%) than in women with vaginal/cervical discharge (0.5%), indicating that basic diagnostic tests may not be cost-effective for diagnosis of vaginal/cervical discharge syndrome. Microscopy when compared with culture showed sensitivity, specificity, positive predictive value and negative predictive value of 95.4%, 77.6%, 84.6%, and 95.3%, in men, whereas in women, it was 77.8%, 99.9%, 92.1%, and 99.9%, respectively...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28073612/gonorrhea-and-chlamydia-in-the-emergency-department-continued-need-for-more-focused-treatment-for-men-women-and-pregnant-women
#17
Sean P Wilson, Taher Vohra, McKenna Knych, Jared Goldberg, Christopher Price, Sean Calo, Meredith Mahan, Joseph Miller
INTRODUCTION: Delay in current nucleic acid amplification testing for Neisseria gonorrhoeae and Chlamydia trachomatis has led to recommendations for presumptive treatment in patients with concern for infection and unreliable follow-up. In the urban setting, it is assumed that many patients have unreliable follow-up, therefore presumptive therapy is thought to be used frequently. We sought to measure the frequency of disease and accuracy of presumptive treatment for these infections. METHODS: This was an observational cohort study performed at an urban academic Level 1 trauma center ED with an annual census of 95,000 visits per year...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28072668/genital-and-extragenital-gonorrhea-and-chlamydia-in-children-and-adolescents-evaluated-for-sexual-abuse
#18
Nancy D Kellogg, John D Melville, James L Lukefahr, Shalon M Nienow, Edward L Russell
OBJECTIVE: The aim of this study was to describe the use of a nucleic acid amplification test in detecting genital and extragenital Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in children and adolescents assessed for sexual abuse/assault. METHODS: The charts of children aged 0 to 17 years, consecutively evaluated for sexual victimization, in emergency department and outpatient settings were reviewed. Data extracted included age, sex, type of sexual contact, anogenital findings, previous sexual contact, toxicology results, and sites tested for NG and CT...
January 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28035227/plasmid-mediated-resistance-to-tetracyclines-among-neisseria-gonorrhoeae-strains-isolated-in-poland-between-2012-and-2013
#19
Beata Młynarczyk-Bonikowska, Marlena Kujawa, Magdalena Malejczyk, Grażyna Młynarczyk, Sławomir Majewski
INTRODUCTION: One of two main mechanisms of resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence of TetM protein responsible for actively blocking of the tetracycline target site in the 30S ribosomal subunit. This mechanism is encoded by conjugative plasmids. The second mechanism is chromosomal in nature and due to mutations in specific genes. AIM: To determine the incidence and type of tetM determinants in TRNG strains isolated from patients presenting with gonorrhea infection to the Dermatology and Venereology Clinic in Warsaw in 2012-2013...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28013414/gonorrhea-infection-increases-the-risk-of-prostate-cancer-in-asian-population-a-nationwide-population-based-cohort-study
#20
Y-C Wang, C-H Chung, J-H Chen, M-H Chiang, Ti-Yin, C-H Tsao, F-H Lin, W-C Chien, S-T Shang, F-Y Chang
This nationwide population-based retrospective cohort study evaluated the risk of developing prostate cancer among patients with gonorrhea. We identified cases of newly diagnosed gonorrhea in men between 2000 and 2010 from the Taiwan National Health Insurance Research Database. Each patient with gonorrhea was matched to four controls, based on age and index year. All subjects were followed up from the index date to December 31, 2010. The Cox proportional hazards regression model was used to assess the risk of prostate cancer...
December 24, 2016: European Journal of Clinical Microbiology & Infectious Diseases
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