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https://www.readbyqxmd.com/read/29145597/laboratory-testing-of-a-cohort-of-commercially-insured-users-of-hiv-preexposure-prophylaxis-in-the-united-states-2011-2015
#1
Ya-Lin A Huang, Guoyu Tao, Taraz Samandari, Karen W Hoover
To ensure the health and safety of persons taking antiretroviral medication for HIV preexposure prophylaxis (PrEP), CDC guidelines recommend initial and follow-up laboratory testing. We assessed the rates of recommended testing using a commercial insurance claims database. Before taking PrEP, 45% of users were tested for HIV, 31% for creatinine, 55% for syphilis, 43% for chlamydia/gonorrhea, and 38% for hepatitis B. By 6 months after PrEP initiation, 38% were tested for HIV, 37% for creatinine, 49% for syphilis, and 39% for chlamydia/gonorrhea...
November 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29142418/marantodes-pumilum-blume-kuntze-inhibited-secretion-of-lipopolysaccharide-and-monosodium-urate-crystal-stimulated-cytokines-and-plasma-prostaglandin-e2
#2
Eldiza Puji Rahmi, Jamia Azdina Jamal, Endang Kumolosasi, Juriyati Jalil, Nor-Ashila Aladdin
Background: Marantodes pumilum is traditionally used for dysentery, gonorrhea, and sickness in the bones. Previous studies revealed its antibacterial and xanthine oxidase inhibitory activities. Objective: To evaluate the inhibitory effects of three M. pumilum varieties on the secretion of lipopolysaccharide (LPS)- and monosodium urate crystal (MSU)-induced cytokines and plasma prostaglandin E2 (PGE2) in vitro. Materials and Methods: The leaves and roots of M...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29136127/risk-of-pelvic-inflammatory-disease-in-relation-to-chlamydia-and-gonorrhea-testing-repeat-testing-and-positivity-a-population-based-cohort-study
#3
Joanne Reekie, Basil Donovan, Rebecca Guy, Jane S Hocking, John M Kaldor, Donna B Mak, Sallie Pearson, David Preen, Louise Stewart, James Ward, Bette Liu
Background: There is uncertainty around whether the risks of pelvic inflammatory disease (PID) differ following Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) infection. We quantified the risk of PID associated with chlamydia and gonorrhea infection and subsequent repeat infections in a whole-population cohort. Methods: A cohort of 315123 Western Australian women, born during 1974-1995, was probabilistically linked to chlamydia and gonorrhea testing records and to hospitalizations and emergency department presentations for PID from 2002 to 2013...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29131864/comparison-of-histone-like-hu-protein-dna-binding-properties-and-hu-ihf-protein-sequence-alignment
#4
Dmitri Kamashev, Yulia Agapova, Sergey Rastorguev, Anna A Talyzina, Konstantin M Boyko, Dmitry A Korzhenevskiy, Anna Vlaskina, Raif Vasilov, Vladimir I Timofeev, Tatiana V Rakitina
BACKGROUND: The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some eukaryotes.HU protein binds dsDNA without sequence specificity and avidly binds DNA structures with propensity to be inclined such as forks, three/four-way junctions, nicks, overhangs and DNA bulges. Sequence comparison of thousands of known histone-like proteins from diverse bacteria phyla reveals relation between HU/IHF sequence, DNA-binding properties and other protein features...
2017: PloS One
https://www.readbyqxmd.com/read/29130407/hiv-and-other-stis-in-male-sex-workers-findings-from-a-sexual-health-promotion-intervention-in-vietnam
#5
Lloyd A Goldsamt, Michael C Clatts, Le Minh Giang, Bao Q Le, Donn J Colby, Gary Yu
Male sex workers (MSWs) in Vietnam are at high risk for acquisition and transmission of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs), yet are extremely disengaged from the healthcare system. This contributes to large numbers of untreated or late-treated infections and increased secondary transmission. We enrolled 995 MSWs in Hanoi and Ho Chi Minh City (HCMC) in a Sexual Health Promotion intervention that included face-to-face delivery of seven content modules, a clinical examination and testing for HIV, syphilis, gonorrhea and Chlamydia...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29126990/a-proanthocyanidin-rich-extract-from-cassia-abbreviata-exhibits-antioxidant-and-hepatoprotective-activities-in-vivo
#6
Mansour Sobeh, Mona F Mahmoud, Mohamed A O Abdelfattah, Haroan Cheng, Assem M El-Shazly, Michael Wink
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia abbreviata is a small to medium sized branched umbrella-shaped deciduous tree. It is widely spread in the tropics, especially in Africa, having a long history in traditional medicine for the treatment of numerous conditions such as headaches, diarrhea, constipation, some skin diseases, malaria, syphilis, pneumonia, stomach troubles, uterine pains, and against gonorrhea. AIM OF THE STUDY: We investigated the phytochemical constituents of a root extract from Cassia abbreviata using HPLC-PDA-ESI-MS/MS...
November 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29100864/sustained-simultaneous-delivery-of-metronidazole-and-doxycycline-from-polycaprolactone-matrices-designed-for-intravaginal-treatment-of-pelvic-inflammatory-disease
#7
Meenakshi Pathak, Allan G A Coombes, BoMi Ryu, Peter J Cabot, Mark S Turner, Cheryn Palmer, Dongjie Wang, Kathryn J Steadman
Poly(ɛ-caprolactone) (PCL) intra-vaginal matrices were produced for local delivery of a combination of antibacterials, by rapidly cooling a mixture of drug powders dispersed in PCL solution. Matrices loaded with different combinations of metronidazole (10, 15 and 20% w/w) and doxycycline (10% w/w), were evaluated in vitro for release behavior and antibacterial activity. Rapid 'burst release' of 8-15% of the doxycycline content and 31-37% of the metronidazole content occurred within 24 h when matrices were immersed in simulated vaginal fluid (SVF) at 37°C...
October 31, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29074030/reliable-rapid-assay-for-gonorrhea-and-chlamydia-in%C3%A2-the%C3%A2-emergency-department
#8
Sean P Wilson, Taher Vohra, Jared Goldberg, Christopher Price, Sean Calo, Meredith Mahan, Joseph Miller
BACKGROUND: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are common sexually transmitted infections seen in the emergency department (ED). Due to an inability to reliably make accurate diagnosis by physical examination, concern for unreliable follow-up, and current delays in diagnostic nucleic acid amplification testing (NAAT), presumptive treatment active against CT and NG, as described by Centers for Disease Control clinical practice guidelines, is often performed. OBJECTIVES: The purpose of this study was to determine whether a rapid, urine NAAT performed in the ED is noninferior in its diagnostic sensitivity compared with a traditional, swab NAAT assay...
October 23, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29046352/the-lignan-manassantin-is-a-potent-and-specific-inhibitor-of-mitochondrial-complex-i-and-bioenergetic-activity-in-mammals
#9
Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang
Dineolignans manassantin A and B from the plant Saururus cernuus are used in traditional medicine to manage a wide range of ailments such as edema, jaundice, and gonorrhea. Cell-based studies have identified several molecular target candidates of manassantin including NF-kappaB, MAPK, STAT3 and hypoxia-inducible factor 1 alpha (HIF-1alpha). It is unclear whether or how these structurally diverse proteins or pathways mediate any of the medical benefits of manassantin in vivo. Moreover, it has been recently reported that manassantin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial respiration in intact mammalian cells and live animals...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29045604/increases-in-neisseria-gonorrhoeae-with-reduced-susceptibility-to-azithromycin-among-men-who-have-sex-with-men-msm-in-seattle-king-county-washington-2012-2016
#10
Lindley A Barbee, Olusegun O Soge, David A Katz, Julia C Dombrowski, King K Holmes, Matthew R Golden
Background: Antimicrobial-resistant Neisseria gonorrhea is a major public health threat. The CDC recommends that clinicians treat gonorrhea with ceftriaxone 250mg plus azithromycin 1g. Resistance to azithromycin could affect gonorrhea control efforts. Methods: We evaluated antimicrobial susceptibility profiles and clinical data of gonococcal isolates collected at the Public Health-Seattle & King County (PHSKC) STD Clinic from 2012-2016, focusing on 2014-2016. We compared cases with CDC azithromycin (AZM) alert value MIC (MIC ≥2 µg/mL) to those with AZM MIC ≤1 µg/mL, and evaluated clinical outcomes...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29042497/a-single-dual-function-enzyme-controls-the-production-of-inflammatory-nod-agonist-peptidoglycan-fragments-by-neisseria-gonorrhoeae
#11
Jonathan D Lenz, Kathleen T Hackett, Joseph P Dillard
Neisseria gonorrhoeae gonococcus (GC) is a Gram-negative betaproteobacterium and causative agent of the sexually transmitted infection gonorrhea. During growth, GC releases lipooligosaccharide (LOS) and peptidoglycan (PG) fragments, which contribute significantly to the inflammatory damage observed during human infection. In ascending infection of human Fallopian tubes, inflammation leads to increased risk of ectopic pregnancy, pelvic inflammatory disease, and sterility. Of the PG fragments released by GC, most are disaccharide peptide monomers, and of those, 80% have tripeptide stems despite the observation that tetrapeptide stems make up 80% of the assembled cell wall...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29028971/infrequent-testing-of-women-for-rectal-chlamydia-and-gonorrhea-in-the-united-states
#12
Guoyu Tao, Karen W Hoover, Melinda B Nye, Philip J Peters, Thomas L Gift, Barbara A Body
Background: Anal sex is a common sexual behavior among women that increases their risk of acquiring rectal infection with Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). Methods: We estimated the frequency and positivity of rectal CT and GC tests for women aged 15-60 years performed by a large U.S. commercial laboratory between November 2012 and September 2015. We also estimated the frequency and positivity of pharyngeal and genital specimens also performed on the same date...
October 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028966/high-rates-of-subsequent-asymptomatic-stis-and-risky-sexual-behavior-in-patients-initially-presenting-with-primary-hiv-1-infection
#13
Dominique L Braun, Alex Marzel, Daniela Steffens, Peter W Schreiber, Christina Grube, Alexandra U Scherrer, Roger D Kouyos, Huldrych F Günthard
Introduction: Knowledge of the characteristics and risk factors of individuals with an asymptomatic sexually transmitted infection (STI) is essential for implementation of targeted STI screening strategies. Methods: Between June 2015 and January 2017 an STI screening was offered to all participants in the Zurich Primary HIV-1 Infection Study. Patients were tested for gonorrhea, chlamydia, syphilis, and hepatitis C virus. Determinants of STI prevalence and incidence were assessed using mixed-model logistic regression and survival analysis...
October 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29027480/a-learning-collaborative-approach-to-improve-primary-care-sti-screening
#14
M Diane McKee, Elizabeth Alderman, Deborah V York, Arthur E Blank, Rahil D Briggs, Kelsey E S Hoidal, Christopher Kus, Claudia Lechuga, Marie Mann, Paul Meissner, Nisha Patel, Andrew D Racine
The Bronx Ongoing Pediatric Screening (BOPS) project sought to improve screening for sexual activity and sexually transmitted infections (gonorrhea and chlamydia [GCC] and HIV) in a primary care network, employing a modified learning collaborative, real-time clinical data feedback to practices, improvement coaching, and a pay-for-quality monetary incentive. Outcomes are compared for 11 BOPS-participating sites and 10 non-participating sites. The quarterly median rate for documenting sexual activity status increased from 55% to 88% (BOPS sites) and from 13% to 74% (non-BOPS sites)...
October 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29017374/prevalence-of-sexually-transmitted-infections-and-their-risk-factors-among-female-sex-workers-in-isfahan-iran-a-cross-sectional-study
#15
Maryam Nasirian, Sina Kianersi, Shervin Ghaffari Hoseini, Nazila Kassaian, Majid Yaran, Parisa Shoaei, Behrooz Ataei, Reza Fadaei, Marjan Meshkati, Alireza Emami Naeini, Mojtaba Rostami Jalilian
OBJECTIVES: Female sex workers (FSWs) are at high risk of sexually transmitted infections (STIs) and form a core group to facilitate STI spreading. We aimed to estimate the prevalence of STIs among FSWs who attended Female Harm Reduction Center of Isfahan, Iran, and to determine the association between risky behaviors and STIs. STUDY DESIGN: In a cross-sectional study, 99 FSWs were recruited and interviewed about demographic characteristics and risky behaviors. A trained midwife examined FSWs for genital ulcer, abnormal vaginal discharge, and cervicitis...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29016383/pathogenesis-of-neisseria-gonorrhoeae-in-the-female-reproductive-tract-neutrophilic-host-response-sustained-infection-and-clinical-sequelae
#16
Jacqueline S Stevens, Alison K Criss
PURPOSE OF REVIEW: Gonorrhea is a major global health concern, caused by the bacterium Neisseria gonorrhoeae. The main clinical feature of acute gonorrhea is neutrophilic influx that is unable to clear infection. Women of reproductive age are predominantly at risk for serious sequelae of gonorrhea, including pelvic inflammatory disease, ectopic pregnancy, and infertility. This review will highlight how neutrophils are recruited to the female reproductive tract (FRT) in response to N. gonorrhoeae, how N...
October 7, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28989988/a-risk-based-model-for-predicting-the-impact-of-using-condoms-on-the-spread-of-sexually-transmitted-infections
#17
Asma Azizi, Karen Ríos-Soto, Anuj Mubayi, James M Hyman
We create and analyze a mathematical model to estimate the impact of condom-use and sexual behavior on the prevalence and spread of Sexually Transmitted Infections (STIs). STIs remain a significant public health challenge globally with a high burden of some Sexually Transmitted Diseases (STDs) in both developed and undeveloped countries. Although condom-use is known to reduce the transmission of STIs, there are a few quantitated population-based studies on the protective role of condom-use in reducing the incidence of STIs...
February 2017: Infectious disease modelling
https://www.readbyqxmd.com/read/28986669/hiv-risk-behaviors-and-utilization-of-prevention-services-urban-and-rural-men-who-have-sex-with-men-in-the-united-states-results-from-a-national-online-survey
#18
Jennie McKenney, Patrick S Sullivan, Kristina E Bowles, Emeka Oraka, Travis H Sanchez, Elizabeth DiNenno
Rural men who have sex with men (MSM) are heavily affected by HIV, and many lack culturally competent HIV prevention resources. Rural MSM may find sexual partners on the internet, which may also be a way to deliver prevention services to them. To understand the differences between rural and urban MSM with respect to HIV risk factors and behaviors and the utilization of online HIV prevention services, we used data from the 2012 Web-Based HIV Behavioral Survey (WHBS). Using WHBS data collected between June and August 2012, we compared the characteristics of MSM with positive or unknown HIV infection status who had sex with a male in the past 12 months, from rural vs urban areas using Chi square tests and median tests...
October 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28982284/public-health-and-vulnerable-populations-morbidity-and-mortality-among-people-ever-incarcerated-in-new-york-city-jails-2001-to-2005
#19
Amber Levanon Seligson, Farah M Parvez, Sungwoo Lim, Tejinder Singh, Maushumi Mavinkurve, Tiffany G Harris, Bonnie D Kerker
The health of people ever incarcerated in New York City (NYC) jails during 2001 to 2005 was characterized by matching jail, shelter, mortality, sexually transmitted infection, HIV, and tuberculosis (TB) data from the NYC Departments of Health and Mental Hygiene, Correction, and Homeless Services. Compared with nonincarcerated people and those living in the lowest income NYC neighborhoods, those ever incarcerated had higher HIV prevalence and HIV case rates. Ever-incarcerated females also had higher rates of gonorrhea and syphilis than nonincarcerated females...
January 1, 2017: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/28982127/use-of-national-standards-to-monitor-hiv-care-and-treatment-in-a-high-prevalence-city-washington-dc
#20
Amanda D Castel, Arpi Terzian, Rachel Hart, Nabil Rayeed, Mariah M Kalmin, Heather Young, Alan E Greenberg
We sought to benchmark the quality of HIV care being received by persons living with HIV in care in Washington, DC and identify individual-level and structural-level differences. Data from the DC Cohort, an observational HIV cohort of persons receiving outpatient care in DC, were used to estimate the Institute of Medicine (IOM) and Department of Health and Human Services (HHS) quality of care measures. Differences in care by demographics and clinic type were assessed using χ2 tests and multivariable regression models...
2017: PloS One
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