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https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#1
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28425904/-testing-is-healthy-timeplay-campaign-evaluation-of-sexual-health-promotion-gamification-intervention-targeting-young-adults
#2
Qinya Zhang, Kim J Huhn, Andy Tan, Rachel E Douglas, Helen Guiyun Li, Michelle Murti, Victoria Lee
OBJECTIVES: The objectives of the study were to 1) describe the implementation of the "Testing is Healthy" campaign in four locations in British Columbia (BC) and 2) report process evaluation indicators for the campaign. PARTICIPANTS: Young adults ages 20-29 years, the age group with the highest reported rates of chlamydia and gonorrhea in BC. SETTINGS: Movie theatres located in Langley, Burnaby, Coquitlam and Surrey, which are communities served by the Fraser Health Authority (FHA) in BC...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28425774/profile-of-the-triplex-assay-for-detection-of-chlamydia-gonorrhea-and-trichomonas-using-the-bd-max%C3%A2-system
#3
Barbara Van Der Pol
Chlamydia, gonorrhea and trichomonas are the most common curable STI. Improved access to testing could reduce infection rates and prevent sequelae. Nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. Areas Covered: A description of the BD MAX™ System (MAX) and the BD MAX CT/GC/TV assay is provided along with data from a large US clinical trial. The capacity of the system for other tests and for lab developed assays is also described...
April 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28414664/gonococcal-endocarditis-the-gift-that-stops-giving-an-uncommon-presentation-of-a-common-disease
#4
G Olayemi, M Oferczak, A Elagizi, I El-Abbassi, M Eschete, J Crowe
INTRODUCTION: Gonorrhea is the 2nd most common sexually transmitted disease in the US with 800,000 cases of gonorrhea each year. Disseminated gonorrhea infection occurs in 0.5 percent - 3 percent of these patients and is more frequent in woman younger than 40 years of age. CASE: A 36 year old woman with a history of polysubstance abuse presented with 10 day history of feeling generally unwell. At presentation, vitals were remarkable for tachycardia and hypotension...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28407651/microscopy-and-culture-for-the-diagnosis-of-gonorrhea-methodological-issues-on-validity-and-reliability
#5
Siamak Sabour
No abstract text is available yet for this article.
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28407644/mobile-phone-and-internet-use-mostly-for-sex-seeking-and-associations-with-sexually-transmitted-infections-and-sample-characteristics-among-black-african-american-and-hispanic-latino-men-who-have-sex-with-men-in-3-us-cities
#6
Jacob E Allen, Gordon Mansergh, Matthew J Mimiaga, Jeremy Holman, Jeffrey H Herbst
BACKGROUND: Men who have sex with men (MSM) have a relatively high prevalence of sexually transmitted infections (STIs). This study examines the association of self-reported STIs and use of mobile phones and/or computer-based Internet to meet sexual partners among black and Hispanic/Latino MSM in the United States. METHODS: Black and Hispanic/Latino MSM (N = 853) were recruited from 3 US cities (Chicago, IL; Kansas City, MO; and Fort Lauderdale, FL) via online and community outreach...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28407641/adverse-birth-outcomes-and-maternal-neisseria-gonorrhoeae-infection-a-population-based-cohort-study-in-washington-state
#7
Christine L Heumann, Laura A S Quilter, McKenna C Eastment, Renee Heffron, Stephen E Hawes
BACKGROUND: Neisseria gonorrhoeae (gonorrhea) remains an important cause of reproductive and obstetric complications. There has been limited population-based research to evaluate the association between maternal gonorrhea and adverse birth outcomes. METHODS: A population-based retrospective cohort study was conducted of women with singleton pregnancies in Washington State from 2003 to 2014 using linked birth certificate and birth hospitalization discharge data. The exposed cohort consisted of women with gonorrhea diagnosed during pregnancy...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28406994/neisseria-gonorrhoeae-infects-the-human-endocervix-by-activating-non-muscle-myosin-ii-mediated-epithelial-exfoliation
#8
Liang-Chun Wang, Qian Yu, Vonetta Edwards, Brian Lin, Jessica Qiu, Jerrold R Turner, Daniel C Stein, Wenxia Song
Colonization and disruption of the epithelium is a major infection mechanism of mucosal pathogens. The epithelium counteracts infection by exfoliating damaged cells while maintaining the mucosal barrier function. The sexually transmitted bacterium Neisseria gonorrhoeae (GC) infects the female reproductive tract primarily from the endocervix, causing gonorrhea. However, the mechanism by which GC overcome the mucosal barrier remains elusive. Using a new human tissue model, we demonstrate that GC can penetrate into the human endocervix by inducing the exfoliation of columnar epithelial cells...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28404485/state-level-gonorrhea-rates-and-expedited-partner-therapy-laws-insights-from-time-series-analyses
#9
K Owusu-Edusei, R Cramer, H W Chesson, T L Gift, J S Leichliter
OBJECTIVE: In this study, we examined state-level monthly gonorrhea morbidity and assessed the potential impact of existing expedited partner therapy (EPT) laws in relation to the time that the laws were enacted. STUDY DESIGN: Longitudinal study. METHODS: We obtained state-level monthly gonorrhea morbidity (number of cases/100,000 for males, females and total) from the national surveillance data. We used visual examination (of morbidity trends) and an autoregressive time series model in a panel format with intervention (interrupted time series) analysis to assess the impact of state EPT laws based on the months in which the laws were enacted...
March 24, 2017: Public Health
https://www.readbyqxmd.com/read/28400529/control-of-gdhr-expression-in-neisseria-gonorrhoeae-via-autoregulation-and-a-master-repressor-mtrr-of-a-drug-efflux-pump-operon
#10
Corinne E Rouquette-Loughlin, Yaramah M Zalucki, Vijaya L Dhulipala, Jacqueline T Balthazar, Raúl G Doyle, Robert A Nicholas, Afrin A Begum, Erica L Raterman, Ann E Jerse, William M Shafer
The MtrCDE efflux pump of Neisseria gonorrhoeae contributes to gonococcal resistance to a number of antibiotics used previously or currently in treatment of gonorrhea, as well as to host-derived antimicrobials that participate in innate defense. Overexpression of the MtrCDE efflux pump increases gonococcal survival and fitness during experimental lower genital tract infection of female mice. Transcription of mtrCDE can be repressed by the DNA-binding protein MtrR, which also acts as a global regulator of genes involved in important metabolic, physiologic, or regulatory processes...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28399349/sexually-transmitted-infections-prevalence-knowledge-and-behaviours-among-professional-defence-forces-in-estonia-a-pilot-study
#11
David Parker, Kristi Rüütel
OBJECTIVES: Our study assessed sexually transmitted infections (STI) occurrence and risk behaviours from a sample of the defence forces of Estonia. Previous research on military personnel yields various results on the prevalence of STIs and high risk behaviours. The increasing recognition of high risk behaviours among military personnel is evident given increased programmes that focus on education of drug use and risky sexual behaviours. Many militaries conduct routine, periodic screening for diseases such as HIV and viral hepatitis at entry and pre-foreign deployment...
March 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28397452/investigation-and-optimization-of-the-effect-of-polymers-on-drug-release-of-norfloxacin-from-floating-tablets
#12
Dipak D Gadade, Kalpana Sarda, Sadhana R Shahi
BACKGROUND: Norfloxacin is fluoroquinolone anti-infective used in the treatment of urinary tract infections, prostatitis, gonorrhea and genital tract infections. It has plasma half life of 3 to 4 h requiring multiple dosing in the treatment. Releaseretarding polymers can be used to modulate the drug release of norfloxacin. OBJECTIVES: The objective of this study was to investigate the effect of release-retarding polymers on the drug release of norfloxacin from floating tablets...
July 2016: Polimery W Medycynie
https://www.readbyqxmd.com/read/28387837/genomic-sequencing-of-neisseria-gonorrhoeae-to-respond-to-the-urgent-threat-of-antimicrobial-resistant-gonorrhea
#13
A Jeanine Abrams, David L Trees
The development of resistance of Neisseria gonorrhoeae to available first-line antibiotics, including penicillins, tetracyclines, fluoroquinolones and cephalosporins, has led to the circulation of multidrug-resistant gonorrhea at a global scale. Advancements in high-throughput whole-genome sequencing (WGS) provide useful tools that can be used to enhance gonococcal detection, treatment and management capabilities, which will ultimately aid in the control of antimicrobial resistant gonorrhea worldwide. In this minireview, we discuss the application of WGS of N...
April 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28373547/emergence-of-a-new-neisseria-meningitidis-clonal-complex-11-lineage-11-2-clade-as-an-effective-urogenital-pathogen
#14
Yih-Ling Tzeng, Jose A Bazan, Abigail Norris Turner, Xin Wang, Adam C Retchless, Timothy D Read, Evelyn Toh, David E Nelson, Carlos Del Rio, David S Stephens
Neisseria meningitidis (Nm) clonal complex 11 (cc11) lineage is a hypervirulent pathogen responsible for outbreaks of invasive meningococcal disease, including among men who have sex with men, and is increasingly associated with urogenital infections. Recently, clusters of Nm urethritis have emerged primarily among heterosexual males in the United States. We determined that nonencapsulated meningococcal isolates from an ongoing Nm urethritis outbreak among epidemiologically unrelated men in Columbus, Ohio, are linked to increased Nm urethritis cases in multiple US cities, including Atlanta and Indianapolis, and that they form a unique clade (the US Nm urethritis clade, US_NmUC)...
April 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28369278/cytomegalovirus-urinary-shedding-in-hiv-infected-pregnant-women-and-congenital-cytomegalovirus-infection
#15
Kristina Adachi, Jiahong Xu, Bonnie Ank, D Heather Watts, Lynne M Mofenson, Jose Henrique Pilotto, Esau Joao, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Glenda Gray, Gerhard Theron, Mariza G Morgado, Yvonne J Bryson, Valdilea G Veloso, Jeffrey D Klausner, Jack Moye, Karin Nielsen-Saines
Background: Cytomegalovirus (CMV) urinary shedding in HIV-infected pregnant women was evaluated to determine whether it poses an increased risk for congenital CMV infection (cCMV). Methods: A subset of mother-infant pairs enrolled in the perinatal NICHD HPTN 040 study (distinguished by no antiretroviral use before labor) was evaluated. Maternal and infant urines were tested by qualitative real-time polymerase chain reaction (RT-PCR) for CMV DNA with quantitative RT-PCR performed on positive specimens...
March 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28369241/neisseria-models-of-infection-and-persistence-in-the-upper-respiratory-tract
#16
Nathan J Weyand
The Gram-negative bacteria genus Neisseria includes both pathogenic and commensal species that are found primarily in the upper respiratory tract of humans and animals. The development of animal models to study neisserial pathogenesis has focused almost exclusively on two species that cause disease in humans. These include Neisseria meningitidis, an obligate commensal that can cause invasive disease, and N. gonorrhoeae, the causative agent of gonorrhea. Both pathogens can persist in the upper respiratory tract...
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28357376/gonorrhea-an-evolving-disease-of-the-new-millennium
#17
REVIEW
Stuart A Hill, Thao L Masters, Jenny Wachter
Etiology, transmission and protection: Neisseria gonorrhoeae (the gonococcus) is the etiological agent for the strictly human sexually transmitted disease gonorrhea. Infections lead to limited immunity, therefore individuals can become repeatedly infected. Pathology/symptomatology: Gonorrhea is generally a non-complicated mucosal infection with a pustular discharge. More severe sequellae include salpingitis and pelvic inflammatory disease which may lead to sterility and/or ectopic pregnancy. Occasionally, the organism can disseminate as a bloodstream infection...
September 5, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28350724/prevalence-and-predictors-of-unsatisfactory-anal-cytology-tests-in-a-cohort-of-gay-and-bisexual-men-in-sydney-australia-baseline-findings-from-the-study-of-the-prevention-of-anal-cancer-spanc
#18
David J Templeton, Jennifer M Roberts, I Mary Poynten, Carmella Law, Richard J Hillman, Annabelle Farnsworth, Christopher K Fairley, Sepehr N Tabrizi, Suzanne M Garland, Andrew E Grulich, Fengyi Jin
Anal cytology has been suggested as a screening test for the anal cancer precursor high-grade squamous intraepithelial lesion (HSIL). We aimed to assess the prevalence and predictors of initial unsatisfactory anal cytology tests ('unsats'). The Study of the Prevention of Anal Cancer is a natural history study of anal human papillomavirus (HPV) and precancerous lesions among gay and bisexual men (GBM) of at least 35 years in Sydney, Australia. At each study visit, an anal swab is collected for cytological testing...
May 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28338951/measuring-transitions-in-sexual-risk-among-men-who-have-sex-with-men-the-novel-use-of-latent-class-and-latent-transition-analysis-in-hiv-sentinel-surveillance
#19
Anna L Wilkinson, Carol El-Hayek, Christopher K Fairley, Norm Roth, B K Tee, Emma McBryde, Margaret Hellard, Mark Stoové
New combination human acquired deficiency (HIV) prevention strategies that include biomedical and primary prevention approaches add complexity to the task of measuring sexual risk. Latent transition models are beneficial for understanding complex phenomena; therefore, we trialed the application of latent class and latent transition models to HIV surveillance data. Our aims were to identify sexual risk states and model individuals' transitions between states. A total of 4,685 HIV-negative men who have sex with men (MSM) completed behavioral questionnaires alongside tests for HIV and sexually transmissible infections at one of 2 Melbourne, Victoria, Australia, general practices (2007-2013)...
April 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28332037/comparing-self-reported-demographic-and-sexual-behavioral-factors-among-men-who-have-sex-with-men-recruited-through-mechanical-turk-qualtrics-and-a-hiv-sti-clinic-based-sample-implications-for-researchers-and-providers
#20
Matthew R Beymer, Ian W Holloway, Christian Grov
Recruitment for HIV research among gay, bisexual, and other men who have sex with men (MSM) has increasingly moved to the online sphere. However, there are limited data comparing the characteristics of clinic-based respondents versus those recruited via online survey platforms. MSM were recruited from three sampling sites (STI clinic, MTurk, and Qualtrics) to participate in a survey from March 2015 to April 2016. Respondents were compared between each of the sampling sites on demographics, sexual history, substance use, and attention filter passage...
March 22, 2017: Archives of Sexual Behavior
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