keyword
https://read.qxmd.com/read/31721185/evaluation-of-cardiovascular-outcomes-in-adult-patients-with-episodic-or-chronic-migraine-treated-with-galcanezumab-data-from-three-phase-3-randomized-double-blind-placebo-controlled-evolve-1-evolve-2-and-regain-studies
#21
RANDOMIZED CONTROLLED TRIAL
Tina M Oakes, Richard Kovacs, Noah Rosen, Erin Doty, Phebe Kemmer, Sheena K Aurora, Angelo Camporeale
OBJECTIVE: Blood pressure (BP), pulse, electrocardiogram (ECG), and clinical cardiovascular (CV) outcomes in patients with episodic or chronic migraine treated for up to 6 months with galcanezumab compared to placebo were evaluated. BACKGROUND: Calcitonin gene-related peptide, a potent microvascular vasodilator, has a hypothesized protective role in CV health. Increased CV risks have been reported in patients with migraine. METHODS: In 2 similarly designed episodic migraine 6-month studies and 1 chronic migraine 3-month study, data from patients randomized (1:1:2) to subcutaneous injection of galcanezumab 120 mg/month (following initial 240 mg loading dose) or 240 mg/month or placebo were pooled...
January 2020: Headache
https://read.qxmd.com/read/31514014/electrographic-indices-in-migraine-patients-a-systematic-review-and-meta-analysis
#22
REVIEW
Sharen Lee, Mengqi Gong, Rachel W C Lai, Fang Zhou Liu, Michael Huen Sum Lam, Dong Chang, Yunlong Xia, Tong Liu, Gary Tse, Ka Hou Christien Li
BACKGROUND AND AIM: Migraine patients can exhibit autonomic dysregulation, in turn leading to cardiac conduction and repolarization abnormalities. This systematic review and meta-analysis evaluated the electrocardiographic changes in migraineurs. METHOD: PubMed and Embase databases were searched for human studies using the search terms 'migraine' and 'electrocardiogram' until 15th December 2018, identifying 108 and 131 studies. RESULTS: Thirteen studies involving 667 migraineurs and 208 normal subjects included (mean age=30...
June 1, 2019: Journal of Electrocardiology
https://read.qxmd.com/read/31146544/long-term-safety-and-tolerability-of-erenumab-three-plus-year-results-from-a-five-year-open-label-extension-study-in-episodic-migraine
#23
JOURNAL ARTICLE
Messoud Ashina, Peter J Goadsby, Uwe Reuter, Stephen Silberstein, David Dodick, Gregory A Rippon, Jan Klatt, Fei Xue, Victoria Chia, Feng Zhang, Sunfa Cheng, Daniel D Mikol
BACKGROUND: Previously published three-month placebo-controlled and one-year open-label clinical trial data have provided information on the efficacy and safety of erenumab. METHODS: Interim analysis was undertaken from an ongoing five-year open-label treatment phase after all patients completed three years in the open-label treatment phase or discontinued the study. Adult patients with episodic migraine enrolled in the open-label treatment phase initially received 70 mg erenumab monthly...
May 30, 2019: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/30659611/stop-101-a-phase-1-randomized-open-label-comparative-bioavailability-study-of-inp104-dihydroergotamine-mesylate-dhe-administered-intranasally-by-a-i123-precision-olfactory-delivery-pod-%C3%A2-device-in-healthy-adult-subjects
#24
RANDOMIZED CONTROLLED TRIAL
Stephen B Shrewsbury, Maria Jeleva, Kelsey H Satterly, Jason Lickliter, John Hoekman
OBJECTIVE: Investigate the safety and pharmacokinetics (PK) of INP104, intranasal dihydroergotamine mesylate (DHE) administered via a Precision Olfactory Delivery (POD® ) device, (Impel NeuroPharma, Seattle, WA) vs intravenous (IV) DHE and DHE nasal spray (Migranal® ) in healthy adult subjects. METHODS: This was a Phase 1, open-label, randomized, single-dose, 3-period, 3-way crossover study. Subjects received a single dose of A) INP104 1.45 mg (a drug-device combination product composed of DHE and the I123 POD device); B) DHE 45® Injection (IV) 1...
March 2019: Headache
https://read.qxmd.com/read/30558049/pacemaker-implantation-for-treating-migraine-like-headache-secondary-to-cardiac-arrhythmia-a-case-report
#25
JOURNAL ARTICLE
Yu-Hong Man, Xiao-Li Meng, Ting-Min Yu, Gang Yao
RATIONALE: Co-occurrence of headache and arrhythmia is not rare. However, their causal relationship remains unclear. Here, we described a case of migraine-like headache relieving with pacemaker implantation. Our case study indicates that arrhythmia is causal for migraine-like headache, which, to our knowledge, has never been reported. PATIENT CONCERNS: A 63-year-old woman patient suffered from paroxysmal headache with a visual aura presenting like migraine for 2 years...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29621539/molecular-determinants-of-kv7-1-kcne1-channel-inhibition-by-amitriptyline
#26
JOURNAL ARTICLE
Kathya Villatoro-Gómez, David O Pacheco-Rojas, Eloy G Moreno-Galindo, Ricardo A Navarro-Polanco, Martin Tristani-Firouzi, Dimitris Gazgalis, Meng Cui, José A Sánchez-Chapula, Tania Ferrer
Amitriptyline (AMIT) is a compound widely prescribed for psychiatric and non-psychiatric conditions including depression, migraine, chronic pain, and anorexia. However, AMIT has been associated with risks of cardiac arrhythmia and sudden death since it can induce prolongation of the QT interval on the surface electrocardiogram and torsade de pointes ventricular arrhythmia. These complications have been attributed to the inhibition of the rapid delayed rectifier potassium current (IKr ). The slow delayed rectifier potassium current (IKs ) is the main repolarizing cardiac current when IKr is compromised and it has an important role in cardiac repolarization at fast heart rates induced by an elevated sympathetic tone...
June 2018: Biochemical Pharmacology
https://read.qxmd.com/read/29355072/topiramate-induced-chest-pain-a-case-report
#27
JOURNAL ARTICLE
Jared L Ostroff, Jessica N LeClair Barnet, Marissa L Ostroff, Corey S Laskey
BACKGROUND: Topiramate, an anticonvulsant used for prophylaxis of migraines and epilepsy, is commonly associated with adverse effects of cognitive dulling and fatigue. Chest pain is a potential adverse effect that to our knowledge has not been reported with the use of topiramate. CASE PRESENTATION: We present the case of a 38-year-old female with a seizure disorder who experienced chest pain after the first dose of topiramate. On day 1, she presented to the emergency department, was admitted, and over the course of 3 days had a chest X-ray, electrocardiogram (ECG), and echocardiogram, and her vitals, basic metabolic panel, complete blood counts, troponin, and d-dimer levels were monitored...
April 2019: Journal of Pharmacy Practice
https://read.qxmd.com/read/28460892/safety-and-efficacy-of-erenumab-for-preventive-treatment-of-chronic-migraine-a-randomised-double-blind-placebo-controlled-phase-2-trial
#28
RANDOMIZED CONTROLLED TRIAL
Stewart Tepper, Messoud Ashina, Uwe Reuter, Jan L Brandes, David Doležil, Stephen Silberstein, Paul Winner, Dean Leonardi, Daniel Mikol, Robert Lenz
BACKGROUND: The calcitonin gene-related peptide (CGRP) pathway is important in migraine pathophysiology. We assessed the efficacy and safety of erenumab, a fully human monoclonal antibody against the CGRP receptor, in patients with chronic migraine. METHODS: This was a phase 2, randomised, double-blind, placebo-controlled, multicentre study of erenumab for adults aged 18-65 years with chronic migraine, enrolled from 69 headache and clinical research centres in North America and Europe...
June 2017: Lancet Neurology
https://read.qxmd.com/read/28251391/a-multicenter-open-label-long-term-safety-and-tolerability-study-of-dfn-02-an-intranasal-spray-of-sumatriptan-10-mg-plus-permeation-enhancer-ddm-for-the-acute-treatment-of-episodic-migraine
#29
MULTICENTER STUDY
Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L H Spierings, Roger K Cady, Alan M Rapoport
BACKGROUND: DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows sumatriptan to be rapidly absorbed into the systemic circulation and exhibit pharmacokinetics comparable to subcutaneously administered sumatriptan. Rapid rate of absorption is suggested to be important for optimal efficacy. The objective of this study was to evaluate the safety and tolerability of DFN-02 (10 mg) in the acute treatment of episodic migraine with and without aura over a 6-month period based on the incidence of treatment-emergent adverse events and the evaluation of results of clinical laboratory tests, vital signs, physical examination, and electrocardiograms...
December 2017: Journal of Headache and Pain
https://read.qxmd.com/read/27769879/individuals-with-tension-and-migraine-headaches-exhibit-increased-heart-rate-variability-during-post-stress-mindfulness-meditation-practice-but-a-decrease-during-a-post-stress-control-condition-a-randomized-controlled-experiment
#30
RANDOMIZED CONTROLLED TRIAL
Muhammad Abid Azam, Joel Katz, Vina Mohabir, Paul Ritvo
BACKGROUND: Current research suggests that associations between headache conditions (migraine, tension) and imbalances in the autonomic nervous system (ANS) are due to stress-related dysregulation in the activity of the parasympathetic-sympathetic branches. Mindfulness meditation has demonstrated effectiveness in reducing pain-related distress, and in enhancing heart rate variability-a vagal-mediated marker of ANS balance. This study examined HRV during cognitive stress and mindfulness meditation in individuals with migraine and tension headaches...
December 2016: International Journal of Psychophysiology
https://read.qxmd.com/read/27754180/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#31
JOURNAL ARTICLE
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://read.qxmd.com/read/27648348/hypercalcemia-of-malignancy
#32
REVIEW
Steve Malangone, Christopher J Campen
A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic treatment with sunitinib (Sutent) and octreotide. He developed intolerable side effects, including nausea and migraine. Therapy was discontinued in October 2011, when a CT scan revealed evidence of disease progression...
2015: Journal of the Advanced Practitioner in Oncology
https://read.qxmd.com/read/27643137/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#33
JOURNAL ARTICLE
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://read.qxmd.com/read/27474357/a-phase-i-open-label-single-dose-safety-pharmacokinetic-and-tolerability-study-of-the-sumatriptan-iontophoretic-transdermal-system-in-adolescent-migraine-patients
#34
RANDOMIZED CONTROLLED TRIAL
Dikla Gutman, Edward Hellriegel, Ernesto Aycardi, Marcelo E Bigal, Jeevan Kunta, Rohini Chitra, Sujay Kansagra, Orna Srur Kidron, Helena Knebel, Steven Linder, Yuju Ma, Mark Pierce, Paul K Winner, Ofer Spiegelstein
OBJECTIVE: To evaluate the safety, tolerability, and pharmacokinetics of sumatriptan delivered by the iontophoretic transdermal system (TDS) in adolescent patients. BACKGROUND: Since nausea can be a prominent and early symptom of migraine, nonoral treatment options are often required. Sumatriptan iontophoretic TDS is approved for the acute treatment of migraine in adults. The present study evaluates the pharmacokinetics of sumatriptan administered via the iontophoretic TDS in adolescents, contrasting the findings with historical data from adults...
September 2016: Headache
https://read.qxmd.com/read/27179636/stunned-myocardium-after-an-anesthetic-procedure-in-a-pediatric-patient-case-report
#35
JOURNAL ARTICLE
Joana Faleiro Oliveira, Susana Rebelo Pacheco, Marta Moniz, Pedro Nunes, Clara Abadesso, Mónica Rebelo, Helena Loureiro, Helena Almeida
Takotsubo syndrome (TTS) is an acquired transient type of systolic dysfunction which mimics myocardial infarction clinically and electrocardiographically. TTS is also known as stress cardiomyopathy, broken heart syndrome, apical ballooning, reversible acute heart failure, neurogenic stunned myocardium or acute catecholamine cardiomyopathy. This case report describes an uncommon presentation of myocardial stunning after an anesthetic procedure. A 14-year-old girl with a history of pineal cyst and hemiplegic migraine was admitted for control brain magnetic resonance imaging...
June 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://read.qxmd.com/read/26879279/safety-and-efficacy-of-amg-334-for-prevention-of-episodic-migraine-a-randomised-double-blind-placebo-controlled-phase-2-trial
#36
RANDOMIZED CONTROLLED TRIAL
Hong Sun, David W Dodick, Stephen Silberstein, Peter J Goadsby, Uwe Reuter, Messoud Ashina, Joel Saper, Roger Cady, Yun Chon, Julie Dietrich, Robert Lenz
BACKGROUND: The calcitonin gene-related peptide (CGRP) pathway is a promising target for preventive therapies in patients with migraine. We assessed the safety and efficacy of AMG 334, a fully human monoclonal antibody against the CGRP receptor, for migraine prevention. METHODS: In this multicentre, randomised, double-blind, placebo-controlled, phase 2 trial, patients aged 18-60 years with 4 to 14 migraine days per month were enrolled at 59 headache and clinical research centres in North America and Europe, and randomly assigned in a 3:2:2:2 ratio to monthly subcutaneous placebo, AMG 334 7 mg, AMG 334 21 mg, or AMG 334 70 mg using a sponsor-generated randomisation sequence centrally executed by an interactive voice response or interactive web response system...
April 2016: Lancet Neurology
https://read.qxmd.com/read/26531280/autonomic-impairment-in-patients-with-migraine
#37
JOURNAL ARTICLE
D Matei, V Constantinescu, C Corciova, B Ignat, R Matei, C D Popescu
OBJECTIVE: Heart rate variability analysis of electrocardiogram is becoming an increasingly common method to non-invasively evaluate autonomic nervous function. The aim of the study was to investigate cardiac autonomic function in subjects with and without migraine by using 24-hour ambulatory electrocardiographic recordings. PATIENTS AND METHODS: We investigated 27 subjects with migraine (10 with migraine with aura and 17 without aura) during headache free periods and 10 age-matched healthy control subjects...
October 2015: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/26166644/the-prevalence-and-clinical-characteristics-of-mitral-valve-prolapse-in-a-large-population-based-epidemiologic-study-the-melen-study
#38
JOURNAL ARTICLE
Y Turker, Y Turker, D Baltaci, C Basar, M Akkaya, H Ozhan
OBJECTIVE: Mitral valve prolapse (MVP) is the most common cardiac valvular abnormality in industrialized countries. Its prevalence has been estimated to be between 2% to 4%. However, some studies found the prevalence of MVP less than 1% which is significantly lower than the prevalence reported in the Framingham Heart Study. The purpose of this study was to determine the prevalence, demographic, clinical and echocardiographic characteristics of MVP in a large population-based epidemiologic study...
June 2015: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/26162766/recalcitrant-supraventricular-tachycardia-occult-albuterol-toxicity-due-to-a-factitious-disorder
#39
JOURNAL ARTICLE
Brandon K Wills, Constance Kwan, Michael Bailey, Leigh Johnson, Nicholas Allan
BACKGROUND: We report a case of a factitious disorder presenting with recurrent episodes of supraventricular tachycardia (SVT). CASE REPORT: A 26-year-old woman presented with recurrent episodes of SVT. Medical history included SVT, asthma, anxiety, depression, type 2 diabetes, and migraine headaches. The patient had frequent emergency department (ED) visits with complaints of chest pain, palpitations, and heart rates typically between 130 and 150 beats/min. Electrocardiograms revealed sinus tachycardia; laboratory studies were consistently normal except for periodic episodes of hypokalemia...
October 2015: Journal of Emergency Medicine
https://read.qxmd.com/read/25998140/high-prevalence-of-concealed-brugada-syndrome-in-patients-with-atrioventricular-nodal-reentrant-tachycardia
#40
JOURNAL ARTICLE
Can Hasdemir, Serdar Payzin, Umut Kocabas, Hatice Sahin, Nihal Yildirim, Alpay Alp, Mehmet Aydin, Ryan Pfeiffer, Elena Burashnikov, Yuesheng Wu, Charles Antzelevitch
BACKGROUND: Atrioventricular nodal reentrant tachycardia (AVNRT) may coexist with Brugada syndrome (BrS). OBJECTIVES: The present study was designed to determine the prevalence of drug-induced type 1 Brugada ECG pattern (concealed BrS) in patients presenting with clinical spontaneous AVNRT and to investigate their electrocardiographic, electrophysiological, and genetic characteristics. METHODS: Ninety-six consecutive patients without any sign of BrS on baseline electrocardiogram undergoing electrophysiological study and ablation for symptomatic, drug-resistant AVNRT and 66 control subjects underwent an ajmaline challenge to unmask BrS...
July 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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