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https://www.readbyqxmd.com/read/27769879/individuals-with-tension-and-migraine-headaches-exhibit-increased-heart-rate-variability-during-post-stress-mindfulness-meditation-practice-but-a-decrease-during-a-post-stress-control-condition-a-randomized-controlled-experiment
#1
Muhammad Abid Azam, Joel Katz, Vina Mohabir, Paul Ritvo
BACKGROUND: Current research suggests that associations between headache conditions (migraine, tension) and imbalances in the autonomic nervous system (ANS) are due to stress-related dysregulation in the activity of the parasympathetic-sympathetic branches. Mindfulness meditation has demonstrated effectiveness in reducing pain-related distress, and in enhancing heart rate variability-a vagal-mediated marker of ANS balance. This study examined HRV during cognitive stress and mindfulness meditation in individuals with migraine and tension headaches...
October 18, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27754180/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#2
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27648348/hypercalcemia-of-malignancy
#3
REVIEW
Steve Malangone, Christopher J Campen
A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic treatment with sunitinib (Sutent) and octreotide. He developed intolerable side effects, including nausea and migraine. Therapy was discontinued in October 2011, when a CT scan revealed evidence of disease progression...
November 2015: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/27643137/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#4
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27474357/a-phase-i-open-label-single-dose-safety-pharmacokinetic-and-tolerability-study-of-the-sumatriptan-iontophoretic-transdermal-system-in-adolescent-migraine-patients
#5
Dikla Gutman, Edward Hellriegel, Ernesto Aycardi, Marcelo E Bigal, Jeevan Kunta, Rohini Chitra, Sujay Kansagra, Orna Srur Kidron, Helena Knebel, Steven Linder, Yuju Ma, Mark Pierce, Paul K Winner, Ofer Spiegelstein
OBJECTIVE: To evaluate the safety, tolerability, and pharmacokinetics of sumatriptan delivered by the iontophoretic transdermal system (TDS) in adolescent patients. BACKGROUND: Since nausea can be a prominent and early symptom of migraine, nonoral treatment options are often required. Sumatriptan iontophoretic TDS is approved for the acute treatment of migraine in adults. The present study evaluates the pharmacokinetics of sumatriptan administered via the iontophoretic TDS in adolescents, contrasting the findings with historical data from adults...
September 2016: Headache
https://www.readbyqxmd.com/read/27179636/stunned-myocardium-after-an-anesthetic-procedure-in-a-pediatric-patient-case-report
#6
Joana Faleiro Oliveira, Susana Rebelo Pacheco, Marta Moniz, Pedro Nunes, Clara Abadesso, Mónica Rebelo, Helena Loureiro, Helena Almeida
Takotsubo syndrome (TTS) is an acquired transient type of systolic dysfunction which mimics myocardial infarction clinically and electrocardiographically. TTS is also known as stress cardiomyopathy, broken heart syndrome, apical ballooning, reversible acute heart failure, neurogenic stunned myocardium or acute catecholamine cardiomyopathy. This case report describes an uncommon presentation of myocardial stunning after an anesthetic procedure. A 14-year-old girl with a history of pineal cyst and hemiplegic migraine was admitted for control brain magnetic resonance imaging...
June 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/26879279/safety-and-efficacy-of-amg-334-for-prevention-of-episodic-migraine-a-randomised-double-blind-placebo-controlled-phase-2-trial
#7
RANDOMIZED CONTROLLED TRIAL
Hong Sun, David W Dodick, Stephen Silberstein, Peter J Goadsby, Uwe Reuter, Messoud Ashina, Joel Saper, Roger Cady, Yun Chon, Julie Dietrich, Robert Lenz
BACKGROUND: The calcitonin gene-related peptide (CGRP) pathway is a promising target for preventive therapies in patients with migraine. We assessed the safety and efficacy of AMG 334, a fully human monoclonal antibody against the CGRP receptor, for migraine prevention. METHODS: In this multicentre, randomised, double-blind, placebo-controlled, phase 2 trial, patients aged 18-60 years with 4 to 14 migraine days per month were enrolled at 59 headache and clinical research centres in North America and Europe, and randomly assigned in a 3:2:2:2 ratio to monthly subcutaneous placebo, AMG 334 7 mg, AMG 334 21 mg, or AMG 334 70 mg using a sponsor-generated randomisation sequence centrally executed by an interactive voice response or interactive web response system...
April 2016: Lancet Neurology
https://www.readbyqxmd.com/read/26531280/autonomic-impairment-in-patients-with-migraine
#8
D Matei, V Constantinescu, C Corciova, B Ignat, R Matei, C D Popescu
OBJECTIVE: Heart rate variability analysis of electrocardiogram is becoming an increasingly common method to non-invasively evaluate autonomic nervous function. The aim of the study was to investigate cardiac autonomic function in subjects with and without migraine by using 24-hour ambulatory electrocardiographic recordings. PATIENTS AND METHODS: We investigated 27 subjects with migraine (10 with migraine with aura and 17 without aura) during headache free periods and 10 age-matched healthy control subjects...
October 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26166644/the-prevalence-and-clinical-characteristics-of-mitral-valve-prolapse-in-a-large-population-based-epidemiologic-study-the-melen-study
#9
Y Turker, Y Turker, D Baltaci, C Basar, M Akkaya, H Ozhan
OBJECTIVE: Mitral valve prolapse (MVP) is the most common cardiac valvular abnormality in industrialized countries. Its prevalence has been estimated to be between 2% to 4%. However, some studies found the prevalence of MVP less than 1% which is significantly lower than the prevalence reported in the Framingham Heart Study. The purpose of this study was to determine the prevalence, demographic, clinical and echocardiographic characteristics of MVP in a large population-based epidemiologic study...
June 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26162766/recalcitrant-supraventricular-tachycardia-occult-albuterol-toxicity-due-to-a-factitious-disorder
#10
Brandon K Wills, Constance Kwan, Michael Bailey, Leigh Johnson, Nicholas Allan
BACKGROUND: We report a case of a factitious disorder presenting with recurrent episodes of supraventricular tachycardia (SVT). CASE REPORT: A 26-year-old woman presented with recurrent episodes of SVT. Medical history included SVT, asthma, anxiety, depression, type 2 diabetes, and migraine headaches. The patient had frequent emergency department (ED) visits with complaints of chest pain, palpitations, and heart rates typically between 130 and 150 beats/min. Electrocardiograms revealed sinus tachycardia; laboratory studies were consistently normal except for periodic episodes of hypokalemia...
October 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25998140/high-prevalence-of-concealed-brugada-syndrome-in-patients-with-atrioventricular-nodal-reentrant-tachycardia
#11
Can Hasdemir, Serdar Payzin, Umut Kocabas, Hatice Sahin, Nihal Yildirim, Alpay Alp, Mehmet Aydin, Ryan Pfeiffer, Elena Burashnikov, Yuesheng Wu, Charles Antzelevitch
BACKGROUND: Atrioventricular nodal reentrant tachycardia (AVNRT) may coexist with Brugada syndrome (BrS). OBJECTIVES: The present study was designed to determine the prevalence of drug-induced type 1 Brugada ECG pattern (concealed BrS) in patients presenting with clinical spontaneous AVNRT and to investigate their electrocardiographic, electrophysiological, and genetic characteristics. METHODS: Ninety-six consecutive patients without any sign of BrS on baseline electrocardiogram undergoing electrophysiological study and ablation for symptomatic, drug-resistant AVNRT and 66 control subjects underwent an ajmaline challenge to unmask BrS...
July 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25819974/cardiac-cephalgia
#12
REVIEW
Yasar Torres-Yaghi, Justin Salerian, Carrie Dougherty
"Cardiac cephalgia" is a type of secondary headache disorder, usually initiated by exertion that is related to myocardial ischemia. Primary exertional headaches such as sex-, cough-, or exercise-induced headaches are typically benign. Cardiac cephalgia, on the other hand, can have life-threatening complications. Due to overlapping features and similarities in presentation, cardiac cephalgia can be misdiagnosed as a primary headache disorder such as migraine. However, the management of these conditions is unique, and treatment of cardiac cephalgia with vasoconstrictors intended for migraine can potentially worsen myocardial ischemia...
April 2015: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/25285391/qtc-prolongation-in-acute-pediatric-migraine
#13
Lindsay J May, Kelly Millar, Karen M Barlow, Frank Dicke
OBJECTIVES: Migraine headache is common in pediatrics and is frequently assessed in emergency departments. Altered cardiac conduction, including prolongation of the QTc interval on electrocardiogram, has been observed in adults during migraine headache and resolves interictally. Prolonged QTc is associated with life-threatening arrhythmia, and many acute and prophylactic therapies for migraine can further prolong the QTc interval. It is the objective of this prospective cohort study to examine whether the QTc interval prolongs significantly during periods of acute migraine headache in children...
June 2015: Pediatric Emergency Care
https://www.readbyqxmd.com/read/24867857/the-increased-distensibility-of-the-wall-of-cerebral-arterial-network-may-play-a-role-in-the-pathogenic-mechanism-of-migraine-headache
#14
S Viola, P Viola, M P Buongarzone, L Fiorelli, P Litterio
The aim was to evaluate whether patients with episodic migraine with (MA+) and without aura (MA-), during the interictal period of migraine would have an altered distensibility of the wall of cerebral arterial network and whether it would play a role in migraine headache. To evaluate the distensibility of the wall of cerebral arterial network, we measured the time-delay in milliseconds (ms) between the R-wave of an electrocardiogram and the arterial pulse wave of cerebral microcirculation (R-APWCMtd) on the frontal cortex detected by near-infrared spectroscopy (NIRS) in 10 patients with MA+ (age 39...
May 2014: Neurological Sciences
https://www.readbyqxmd.com/read/24866108/evaluation-of-cardiovascular-parameters-in-cynomolgus-monkeys-following-iv-administration-of-lbr-101-a-monoclonal-antibody-against-calcitonin-gene-related-peptide
#15
Sarah Walter, Abbas Alibhoy, Rafael Escandon, Marcelo E Bigal
Calcitonin gene-related peptide (CGRP) is a well-validated target for migraine therapy and a known potent systemic vasodilator. LBR-101 is a monoclonal antibody against CGRP in clinical development for the preventive treatment of episodic and chronic migraine. Understanding the hemodynamic and cardiovascular consequences of chronic CGRP inhibition is therefore warranted. Given the conservation in CGRP sequence between monkeys and humans, addressing this question in monkeys is ideal as it allows dosing at super-therapeutic levels...
July 2014: MAbs
https://www.readbyqxmd.com/read/24608586/creatin-kinase-elevation-after-accidental-ingestion-of-almotriptan-in-an-18-month-old-girl
#16
E Castagno, M Lupica, S Viola, F Savino, R Miniero
Few studies have been published to demonstrate tolerability and efficacy of almotriptan in adolescents and children with migraine, particularly in the first years of life, though preliminary results are favorable. We report the case of an 18-month-old infant with elevation of serum levels of creatin-kinase after the accidental ingestion of almotriptan. A previously healthy 18-month-old girl (weight: 13 kg) was admitted to our Department four hours after the accidental ingestion of 6.25 mg of almotriptan (0...
February 2014: Minerva Pediatrica
https://www.readbyqxmd.com/read/24399200/assessment-of-atrial-electromechanical-delay-in-patients-with-migraine
#17
Asuman Celikbilek, Savas Sarikaya, Gokmen Zararsiz, Nermin Tanik, Ali Riza Erbay
Evidence suggests that symptoms of migraine are related to the involvement of the autonomic nervous system. Data on atrial conduction system are limited in migraineurs. We aimed to assess atrial electromechanical delay using tissue Doppler imaging (TDI) in patients with migraine. Forty-five migraine patients and age- and sex-matched 26 control subjects were enrolled in the study. All the patients and controls underwent resting surface electrocardiogram (ECG) and TDI. The maximum P-wave duration (Pmax), minimum P-wave duration (Pmin) and P-wave dispersion (Pd) were measured from the 12-lead ECG...
December 2014: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/24100257/takotsubo-syndrome-or-apical-ballooning-syndrome-secondary-to-zolmitriptan
#18
Jalaj Garg, Wilbert S Aronow, Srikala Devabhaktuni, Hasan Ahmad
Takotsubo syndrome (TS), also known as broken heart syndrome, is characterized by left ventricle apical ballooning with elevated cardiac biomarkers and electrocardiographic changes suggestive of an acute coronary syndrome (ie, ST-segment elevation, T wave inversions, and pathologic Q waves). We report a case of 54-year-old woman with medical history of mitral valve prolapse and migraines, who was admitted to the hospital for substernal chest pain and electrocardiogram demonstrated 1/2 mm ST-segment elevation in leads II, III, aVF, V5, and V6 and positive troponin I...
March 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/23695061/a-new-near-infrared-spectroscopy-parameter-as-marker-for-patients-with-migraine
#19
S Viola, P Viola, P Litterio, M P Buongarzone, L Fiorelli
Due to the lack of markers for migraine, diagnosis relies entirely on symptomatology. The aim is to evaluate the utility of a new near-infrared spectroscopy parameter as potential marker for patients with episodic migraine with (MA+) and without aura (MA-) during the interictal period of migraine. We studied 10 patients with MA+ (age 39.5 ± 12.2 years) and 10 with MA- (age 40.3 ± 10.2 years), according to ICHD-II criteria 2004, during the interictal period of migraine and 15 age and sex matched healthy control subjects...
May 2013: Neurological Sciences
https://www.readbyqxmd.com/read/23216317/qt-prolongation-torsade-de-pointes-myocardial-ischemia-from-coronary-vasospasm-and-headache-medications-part-1-review-of-serotonergic-cardiac-adverse-events-with-a-triptan-case
#20
REVIEW
Mark J Stillman, Stewart Tepper, Deborah E Tepper, Leslie Cho
Serotonin (5-hydroxytryptamine)(1B/1D) agonists are vasoconstrictors that can affect coronary and cerebral arteries. Retrosternal chest, arm, and jaw pain following triptan use is generally attributed to "triptan sensations" and dismissed as noncardiac. However, triptans narrow normal coronary arteries and occasionally trigger vasospasm. They are contraindicated in atherosclerotic vascular disease. Part 1 of this review examines the relationship of medications used in migraine with the likelihood of causing vasospasm or vasoconstriction, and the triggering of cardiac arrhythmias...
January 2013: Headache
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