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https://www.readbyqxmd.com/read/29149109/targeted-therapies-precision-medicine-for-atc-braf-and-mek-inhibition-shows-promise
#1
David Killock
No abstract text is available yet for this article.
December 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29147889/association-of-il-10-gene-polymorphism-819c%C3%A2-%C3%A2-t-592c%C3%A2-%C3%A2-a-and-1082g%C3%A2-%C3%A2-a-with-preterm-birth
#2
Monika Pandey, Shally Awasthi, Urmila Singh, Abbas Ali Mahdi
OBJECTIVE: To analyze the association of IL-10 gene and its polymorphisms with preterm birth (PTB). METHODS: Five hundred and fifty nine women with term birth and 559 with preterm birth were recruited from Lucknow, India. Genetic association analysis was conducted between cases and controls. Subjects recruited as cases were women (aged between 18-40 y) with singleton delivery before 37 wk of gestation and controls were with delivery after or on 37 wk. The genotyping was performed for rs1800871, rs1800872 and rs1800896 for assessing the allelic distribution, haplotypic association and linkage disequilibrium analysis...
November 17, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29137300/patz1-knockdown-enhances-malignant-phenotype-in-thyroid-epithelial-follicular-cells-and-thyroid-cancer-cells
#3
Asumi Iesato, Teruo Nakamura, Hiroto Izumi, Takeshi Uehara, Ken-Ichi Ito
This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. Immunohistochemistry on clinical specimens indicated nuclear PATZ1 expression in all normal thyroid glands and adenomatous goiter, while nuclear PATZ1 expression decreased along with the dedifferentiation of thyroid cancer. Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135302/in-memory-clint-thompson-ms-atc
#4
Craig R Denegar
No abstract text is available yet for this article.
October 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29127087/dabrafenib-plus-trametinib-is-active-in-braf-v600e-anaplastic-thyroid-cancer
#5
(no author information available yet)
Dual BRAF/MEK inhibition achieves responses in 69% of BRAFV(600E) anaplastic thyroid cancers (ATC).
November 10, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29123502/anaplastic-thyroid-cancer-in-sicily-the-role-of-environmental-characteristics
#6
Martina Tavarelli, Pasqualino Malandrino, Paolo Vigneri, Pierina Richiusa, Adele Maniglia, Maria A Violi, Giulia Sapuppo, Veronica Vella, Gabriella Dardanoni, Riccardo Vigneri, Gabriella Pellegriti
Background: Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA. Methods: Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29121199/the-next-19-years-of-the-american-head-and-neck-society
#7
Jeffrey N Myers
Jeffrey N. Myers, MD, PhD, president of the American Head and Neck Society (AHNS) for 2016 to 2017, offered his perspectives on the AHNS's history, present-day activities, and future plans at this year's annual meeting of the society. The society was created from the 1998 merger of 2 societies, the Society for Head and Neck Surgeons (SHNS), founded in 1954, and the American Society for Head and Neck Surgery (ASHNS), founded in 1959, to become the largest organization in North America for the advancement of research and education in head and neck oncology...
November 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29114718/ascertainment-of-self-reported-prescription-medication-use-compared-with-pharmaceutical-claims-data
#8
Danijela Gnjidic, Wei Du, Sallie-Anne Pearson, Sarah N Hilmer, Emily Banks
BACKGROUND: Evidence on the comparative validity of self-reported medication use in large-scale studies is limited. This study compared self-reported medication use of prescription-only medications to gold standard pharmaceutical claims (i.e. dispensing) data. METHODS: We selected a random sample of 500 participants from the 45 and Up Study, a large-scale Australian study, with complete ascertainment of Pharmaceutical Benefits Scheme dispensing records. Self-reported medication use was ascertained by questionnaire requesting data on medications used "for most of the last 4 weeks"...
October 11, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/29091214/validation-of-adapted-daily-dose-definitions-for-hospital-antibacterial-drug-use-evaluation-a-multicentre-study
#9
Gesche Först, Katja de With, Nadine Weber, Johannes Borde, Christiane Querbach, Johannes Kleideiter, Claudia Seifert, Stefan Hagel, Andreas Ambrosch, Micha Löbermann, Philipp Schröder, Michaela Steib-Bauert, Winfried V Kern
Background: The WHO/ATC (Anatomical Therapeutic Chemical) index DDD (WHO-DDD) is commonly used for drug consumption measurement. Discrepancies between WHO-DDD and actual prescribed daily doses (PDD) in hospitals have prompted alternative dose definitions adapted to doses recommended in hospital practice guidelines [recommended daily doses (RDD)]. Methods: In order to validate RDD we performed modified point prevalence surveys in 24 acute care hospitals and recorded 20620 PDD of antibiotics given to 4226 adult patients on the day of the survey and the 6 preceding days...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29074134/severe-traumatic-brain-injuries-in-children-does-the-type-of-trauma-center-matter
#10
James M Bardes, Elizabeth Benjamin, Agustin Alvarez Escalante, Jinglan Wu, Demetrios Demetriades
BACKGROUND: Traumatic brain injury (TBI) is the leading cause of death among injured children. Depending on geographic location, and trauma resources, pediatric patients may be treated at pediatric (PTC), adult (ATC), or mixed trauma centers (MTC). The effect of the type of trauma center on outcomes in severe TBI is not known. METHODS: NTDB study (2007-2014), level 1 trauma centers, patients ≤14years with severe isolated TBI (head AIS≥3 and extracranial AIS≤2)...
October 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29057760/anaplastic-thyroid-carcinoma-treated-with-lenvatinib
#11
Jun-Ichi Ohkubo, Azusa Takahashi, Shoji Ikezaki, Fumiko Takenaga, Yufu Ohkubo, Hideaki Suzuki
OBJECTIVE: We report a case of anaplastic thyroid carcinoma (ATC) with local recurrence and distant metastasis that responded very well to treatment with lenvatinib, a new molecular-targeted anticancer drug. CASE REPORT: A 91-year-old Japanese woman presented with a 5-month history of a painless mass in her left anterior neck. She had a past history of total thyroidectomy and neck dissection for papillary carcinoma of the thyroid. Here she underwent neck dissection, and the histopathological diagnosis was lymph node metastasis of papillary carcinoma with anaplastic transformation...
October 20, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/29032724/reintroducing-the-sodium-iodide-symporter-to-anaplastic-thyroid-carcinoma
#12
Kathrin A Schmohl, Patrick Dolp, Christina Schug, Kerstin Knoop, Kathrin Klutz, Nathalie Schwenk, Peter Bartenstein, Peter J Nelson, Manfred Ogris, Ernst Wagner, Christine Spitzweg
BACKGROUND: Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC. METHODS: The study employed nanoparticle vectors (polyplexes) based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG) and coupled to the synthetic peptide GE11 as an epidermal growth factor receptor (EGFR)-specific ligand in order to target a NIS-expressing plasmid (LPEI-PEG-GE11/NIS) to EGFR overexpressing human thyroid carcinoma cell lines...
November 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29029287/survival-in-response-to-multimodal-therapy-in-anaplastic-thyroid-cancer
#13
Naiyarat Prasongsook, Aditi Kumar, Ashish V Chintakuntlawar, Robert L Foote, Jan Kasperbauer, Julian Molina, Yolanda Garces, Daniel Ma, Michelle A Neben Wittich, Joseph Rubin, Ronald Richardson, John Morris, Ian Hay, Vahab Fatourechi, Bryan McIver, Mabel Ryder, Geoffrey Thompson, Clive Grant, Melanie Richards, Thomas J Sebo, Michael Rivera, Vera Suman, Sarah M Jenkins, Robert C Smallridge, Keith C Bible
Context: Historical outcomes in anaplastic thyroid cancer (ATC) have been dismal. Objective: To define whether initial intensive multimodal therapy combining surgery, chemotherapy, and radiation might be associated with improved ATC survival. Design: Multimodal therapy was offered to all newly-diagnosed ATC patients treated at the Mayo Clinic, 2003-2015; multimodal vs. palliative therapy was individualized considering clinical status and patient preferences...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29025766/car-t-therapy-targeting-icam-1-eliminates-advanced-human-thyroid-tumors
#14
Irene M Min, Enda Shevlin, Yogindra Vedvyas, Marjan Zaman, Brian Wyrwas, Theresa Scognamiglio, Maureen D Moore, Weibin Wang, Susan Park, Spencer Park, Suraj Panjwani, Katherine D Gray, Andrew B Tassler, Rasa Zarnegar, Thomas J Fahey, Moonsoo M Jin
PURPOSE: Poorly-differentiated thyroid cancer and anaplastic thyroid cancer (ATC) are rare yet lethal malignancies with limited treatment options. Many malignant tumors including papillary thyroid cancer (PTC) and ATC are associated with increased expression of ICAM-1, providing a rationale for utilizing ICAM-1-targeting agents for the treatment of aggressive cancer. We developed a third-generation CAR targeting ICAM-1 to leverage adoptive T cell therapy as a new treatment modality. EXPERIMENTAL DESIGN: ICAM-1 CAR T cells were applied on multiple malignant and non-malignant target cells to investigate specific target cell death and 'off-tumor' toxicity in vitro...
October 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29019001/anaplastic-thyroid-cancer-and-hyperfractionated-accelerated-radiotherapy-hart-with-and-without-surgery
#15
Anne-Birgitte Jacobsen, Krystyna K Grøholt, Bianca Lorntzsen, Terje A Osnes, Ragnhild Sørum Falk, Eva Sigstad
Anaplastic carcinoma of the thyroid gland (ATC) is one of the most aggressive cancers in humans. With insufficient treatment, the disease most often leads to death in suffocation. From 2002, our treatment strategy has been hyperfractionated accelerated radiotherapy (HART) with high doses (64 Gy) to the neck, followed by surgery 4-8 weeks later if feasible, with the aim to gain control in the neck. After a pathology review, 51 patients were diagnosed with ATC in the period 2002-2014 in the south-east of Norway...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29018997/gastrointestinal-perforation-related-to-lenvatinib-an-anti-angiogenic-inhibitor-that-targets-multiple-receptor-tyrosine-kinases-in-a-patient-with-metastatic-thyroid-cancer
#16
Emi Date, Kunio Okamoto, Souichi Fumita, Hiroyasu Kaneda
Lenvatinib, a novel potent multikinase inhibitor, was approved for the treatment of radioiodine-refractory differentiated thyroid cancer based on results from phase III trial (SELECT study). Thyroid cancer is a diverse disease that includes anaplastic thyroid cancer (ATC), which the most aggressive form of the disease, although it accounts for <2% of all thyroid cancers. Current treatments for ATC have limited efficacy. We report the case of a woman with recurrent well-differentiated papillary carcinoma of the thyroid that had transformed into ATC who developed a perforation of the small intestine secondary to a marked effect of lenvatinib...
October 11, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28990697/c9-12-ribbon-like-structure-in-hybrid-peptides-alternating-%C3%AE-and-thiazole-based-%C3%AE-amino-acids
#17
Clément Bonnel, Baptiste Legrand, Matthieu Simon, Jean Martinez, Jean-Louis Bantignies, Young Kee Kang, Emmanuel Wenger, François Hoh, Nicolas Masurier, Ludovic Thierry Maillard
According to their restricted conformational freedom, heterocyclic γ-amino acids are usually considered related to Z-vinylogous γ-amino acids. In such a context, oligomers alternating α- and thiazole-based γ-amino acids, named ATCs were expected to fold into a canonical 12-helical shape as described for α/γ-hybrid peptides composed of cis α/β-unsaturated γ-amino acids. However, we herein demonstrate by combining X-ray crystallography, NMR and FT-IR experiments and DFT calculations that the folding behavior of ATC-containing hybrid peptides is much more complex...
October 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28990511/sunitinib-in-the-treatment-of-thyroid-cancer
#18
Ferrari Silvia Martinaa, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro, Fallahi Poupak
BACKGROUND: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28983286/inducible-expression-of-spo0a-as-a-universal-tool-for-studying-sporulation-in-clostridium-difficile
#19
Marcin Dembek, Stephanie E Willing, Huynh A Hong, Siamand Hosseini, Paula S Salgado, Simon M Cutting
Clostridium difficile remains a leading nosocomial pathogen, putting considerable strain on the healthcare system. The ability to form endospores, highly resistant to environmental insults, is key to its persistence and transmission. However, important differences exist between the sporulation pathways of C. difficile and the model Gram-positive organism Bacillus subtilis. Amongst the challenges in studying sporulation in C. difficile is the relatively poor levels of sporulation and high heterogeneity in the sporulation process...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28964784/synergistic-efficacy-of-irinotecan-and-sunitinib-combination-in-preclinical-models-of-anaplastic-thyroid-cancer
#20
Teresa Di Desidero, Alessandro Antonelli, Paola Orlandi, Silvia Martina Ferrari, Anna Fioravanti, Greta Alì, Gabriella Fontanini, Fulvio Basolo, Giulio Francia, Guido Bocci
The identification of new therapeutic strategies is urgently needed for the management of patients affected by anaplastic thyroid cancer (ATC) due to their short survival and poor prognosis. Aim of the study was to determine the activity of the combination irinotecan/sunitinib on ATC cell growth in vitro and the antitumor effects in vivo. Proliferation assays were performed for 72 h on ATC cell lines exposed to the combination of SN-38, the active metabolite of irinotecan, and sunitinib. The simultaneous combination of sunitinib and SN-38, quantified by the combination index, determined a high synergism on ATC cells, increasing the intracellular concentrations of SN-38...
September 28, 2017: Cancer Letters
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