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https://www.readbyqxmd.com/read/29791160/interaction-of-zwitterionic-and-ionic-monomers-with-graphene-surfaces
#1
Suguna Perumal, Atchudan Raji, In Woo Cheong
Measurement of the interaction force between two materials provides important information on various properties, such as adsorption, binding or compatibility for coatings, adhesion, and composites. The interaction forces of zwitterionic and ionic monomers with graphite platelets (G) and reduced graphene oxide (rGO) surfaces were systematically investigated using atomic force microscopy (AFM) in air and water. The monomers examined were 2-(methacryloyloxy)ethyl 2-(trimethylammonio)ethyl phosphate (MPC), [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBE), [2-(acryloyloxy)ethyl]trimethylammonium chloride (ATC), and 2-methyl-2-propene-1-sulfonic acid sodium (MSS)...
May 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29791034/high-expression-of-cd10-in-anaplastic-thyroid-carcinomas
#2
Tadao Nakazawa, Tetsuo Kondo, Huy Gia Vunong, Toru Odate, Masataka Kawai, Ippei Tahara, Kazunari Kasai, Tomohiro Inoue, Naoki Oishi, Kunio Mochizuki, Koichi Ito, Ryohei Katoh
AIMS: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. However, its presence is not fully determined in thyroid carcinomas, especially in anaplastic thyroid carcinoma (ATC). METHODS AND RESULTS: We examined CD10 by immunohistochemistry (IHC) in 152 thyroid lesions: 9 adenomatous goiters (AGs) and 143 tumors including 47 anaplastic carcinomas...
May 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29790111/potential-of-the-dual-mtor-kinase-inhibitor-azd2014-to-overcome-paclitaxel-resistance-in-anaplastic-thyroid-carcinoma
#3
Zorica Milošević, Jasna Banković, Jelena Dinić, Chrisiida Tsimplouli, Evangelia Sereti, Miodrag Dragoj, Verica Paunović, Zorka Milovanović, Marija Stepanović, Nikola Tanić, Kostantinos Dimas, Milica Pešić
PURPOSE: Anaplastic thyroid carcinoma (ATC) is an aggressive, chemo-resistant malignancy. Chemo-resistance is often associated with changes in activity of the RAS/MAPK/ERK and PI3K/AKT/mTOR pathways and/or a high expression of ATP binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). To assess the therapeutic efficacy in ATC of a combination of the dual mTOR kinase inhibitor vistusertib (AZD2014) and paclitaxel (PTX), we generated a new cell line (Rho-) via the selection of human thyroid carcinoma 8505C cells that exhibit a low accumulation of rhodamine 123, which serves as a P-gp and BCRP substrate...
May 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29781758/analysis-of-the-drug-formulary-and-the-purchasing-process-at-a-moroccan-university-medical-center
#4
Z Lachhab, S Serragui, M Hassar, Y Cherrah, A Errougani, S Ahid
AIM: To give an overview of the pharmaceutical policy in the largest medical center in Morocco, a developing country in socio-economic transition. METHODS: This is an analytical descriptive study of the drug formulary and the purchasing process carried out at the Ibn Sina University Medical Center. RESULTS: Our formulary included 830 drugs belonging to 14 classes according to the Anatomical, Therapeutic and Chemical (ATC) Classification System...
May 21, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29774792/hypofractionated-radiotherapy-is-superior-to-conventional-fractionation-in-an-orthotopic-model-of-anaplastic-thyroid-cancer
#5
Ayman J Oweida, Andy Phan, Benjamin Vancourt, Tyler Robin, Mohammad K Hararah, Shilpa Bhatia, Dallin Milner, Shelby Lennon, Laura Pike, David Raben, Bryan R Haugen, Nikita Pozdeyev, Rebecca E Schweppe, Sana D Karam
Anaplastic thyroid cancer is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment including radiation therapy and chemotherapy, response rates remain below 15% with a median time to progression of less than 3 months. Recent advances in radiotherapy delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative radiotherapy fractionation schedules for overcoming radioresistance...
May 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29767298/-complications-and-side-effects-of-conservative-treatment-of-rhinological-diseases
#6
REVIEW
I Küster, C Rudack, A Beule
BACKGROUND: The spectrum of rhinological diseases is wide, as is that of their drug-based treatment. Only 1272 compounds coded R01 (nasal preparations) are listed in the ATC group (Anatomical Therapeutic Chemical Classification). Conservative therapy of rhinological diseases additionally includes systemic (often oral) application of corticosteroids, antibiotics and immunomodulators. OBJECTIVE: The aim of this paper is to outline possible complications of medication (subdivided into classes of ingredients) commonly used to treat rhinological diseases in hospitals...
May 16, 2018: HNO
https://www.readbyqxmd.com/read/29762469/individualised-multimodal-treatment-strategies-for-anaplastic-and-poorly-differentiated-thyroid-cancer
#7
Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch, Pietro Di Fazio
The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter ( NIS ) and radioiodine up-take (RAI-U)...
May 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29760929/statin-associated-myopathy-assessment-of-frequency-based-on-data-of-all-statutory-health-insurance-funds-in-germany
#8
Peter Ihle, Franz-Werner Dippel, Ingrid Schubert
Aim of the study was to assess the incidence of statin-associated myopathy (SAM) under real-life conditions in Germany. DATABASE: Administrative data (master data, diagnoses, prescriptions) for all individuals in Germany insured with the Statutory Health Insurance. Basic population: individuals 18 years and older who have been insured continually from 2009 to 2011 (52.9 million; 29.9 million men, 23.9 million women). Data access is provided by the German Institute of Medical Documentation and Information, DIMDI) according to the Data Transparency Regulation of 2012...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29747254/-effect-of-il-11-on-the-invasive-and-metastatic-abilities-of-anaplastic-thyroid-carcinoma-cells
#9
Y E Jiang, Z M Zhong, X Chen, W Wang, J Z Luo, S Q Wang, H Y Chu, C Z Sun
Objective: To explore the effect of hematopoietic cytokines IL-11 on invasion and metastasis abilities of anaplastic thyroid cacinoma(ATC) cells. Methods: Real-time PCR was performed for examining the IL-11 mRNA expression in thyroid carcinoma cell lines, and IL-11 protein expression in the supernament of thyroid carcinoma cell lines was detected by ELISA. Molecular cloning was employed to construct IL-11 stable knockdown cell line; MTT assay was used to analyze the effect of IL-11 on the proliferation of ATC cells; Transwell and wound healing assays were employed to analyze the abilities of migration and invasion in ATC cells...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29742974/neoadjuvant-braf-and-immune-directed-therapy-for-anaplastic-thyroid-carcinoma
#10
Maria Cabanillas, Renata Ferrarotto, Adam Garden, Salmaan Ahmed, Naifa Busaidy, Ramona Dadu, Michelle D Williams, Heath Skinner, Brandon Gunn, Horiana Grosu, Priyanka C Iyer, Marie-Claude Hofmann, Mark Zafereo
Anaplastic thyroid cancer (ATC) is a devastating disease with a dismal prognosis. Patients who have disease confined to the thyroid and who are able to undergo complete surgery and chemoradiation stand the best chance for survival. Unfortunately, nearly 50% of patients at diagnosis have distant metastases at diagnosis and most present with locally advanced, unresectable tumors. Nevertheless, BRAF-mutated ATC patients represent a subset of cases who can benefit from a combination therapy with BRAF and /MEK inhibitors...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29739776/prevalence-of-treatment-resistant-hypertension-after-considering-pseudo-resistance-and-morbidity-a-cross-sectional-study-in-irish-primary-care
#11
Peter Hayes, Monica Casey, Liam G Glynn, Gerard J Molloy, Hannah Durand, Eoin O'Brien, Eamon Dolan, John Newell, Andrew W Murphy
BACKGROUND: To confirm treatment-resistant hypertension (TRH), ambulatory blood pressure measurement (ABPM) must exclude white-coat hypertension (WCH), three or more medications should be prescribed at the optimal doses tolerated, and non-adherence and lifestyle should be examined. Most previous studies have not adequately considered pseudo-resistance and merely provide an apparent TRH (aTRH) prevalence figure. AIM: To conduct a cross-sectional study of the prevalence of aTRH in general practice, and then consider pseudo-resistance and morbidity...
May 8, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29737325/the-mek1-2-inhibitor-azd6244-sensitizes-braf-mutant-thyroid-cancer-to-vemurafenib
#12
Hao Song, Jinna Zhang, Liang Ning, Honglai Zhang, Dong Chen, Xuelong Jiao, Kejun Zhang
BACKGROUND [i]BRAF[/i]V600E mutation occurs in approximately 45% of papillary thyroid cancer (PTC) cases, and 25% of anaplastic thyroid cancer (ATC) cases. Vemurafenib/PLX4032, a selective BRAF inhibitor, suppresses extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 (MEK/ERK1/2) signaling and shows beneficial effects in patients with metastatic melanoma harboring the [i]BRAFV600E[/i] mutation. However, the response to vemurafenib is limited in BRAF-mutant thyroid cancer. The present study evaluated the effect of vemurafenib in combination with the selective MEK1/2 inhibitor AZD6244 on cell survival and explored the mechanism underlying the combined effect of vemurafenib and AZD6244 on thyroid cancer cells harboring BRAFV600E...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29719407/evidence-from-an-updated-meta-analysis-of-the-prognostic-impacts-of-postoperative-radiotherapy-and-chemotherapy-in-patients-with-anaplastic-thyroid-carcinoma
#13
Quansong Xia, Wei Wang, Juan Xu, Xue Chen, Zhaoming Zhong, Chuanzheng Sun
Background: Radiotherapy and chemotherapy are the two important postoperative management approaches for anaplastic thyroid carcinoma (ATC), and several studies have suggested that postoperative radiotherapy and chemotherapy can prolong the survival of patients with ATC. However, the results remain inconsistent. Objective: A meta-analysis was performed to address whether postoperative radiotherapy and chemotherapy could prolong the survival of patients with ATC. Methods: Relevant studies were included, and pooled hazard ratios (HRs) together with 95% confidence intervals (CIs) were calculated...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29717765/bromodomain%C3%A2-containing-protein-4-is-critical-for-the-antiproliferative-and-pro%C3%A2-apoptotic-effects-of-gambogic-acid-in-anaplastic-thyroid-cancer
#14
Yonghui Wang, Wei Wang, Hongqin Sun
Gambogic acid (GA) has been widely used as an anticancer drug for different tumors, including thyroid cancer. However, the potential function and molecular mechanisms of GA in anaplastic thyroid cancer (ATC) has not been illustrated thus far. The aim of the present study was to demonstrate the antitumor effects of GA on ATC cells and investigate its underlying molecular mechanisms. The results revealed that GA significantly decreased the viability and proliferation, as well as induced cell apoptosis in ATC cell lines...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29709253/2-methylacrylamide-as-a-bioisoster-of-thiourea-group-for-1-3-dibenzylthioureido-trpv1-receptor-antagonists
#15
Seol Rin Park, Juhyun Kim, Sun Young Lee, Young-Ho Park, Hee-Doo Kim
In order to replace thiourea group with the more drug-like moiety for 1,3-dibenzylthioureas having TRPV1 antagonist activity, we introduced a set of functional groups between the two aromatic rings based on bioisosteric replacement. The synthesized bioisosteres of 1,3-dibenzylthioureas were tested for their antagonist activities on TRPV1 by 45 Ca2+ -influx assay using neonatal rat cultured spinal sensory neurons. Among the tested 14 kinds of bioisosters, 2-methylacrylamide group was the best candidate to replace thiourea group...
April 17, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29701217/a-reaction-based-ratiometric-fluorescent-sensor-for-the-detection-of-hg-ii-ions-in-both-cells-and-bacteria
#16
Sheng-Lin Pan, Kun Li, Ling-Ling Li, Meng-Yang Li, Lei Shi, Yan-Hong Liu, Xiao-Qi Yu
A novel reaction-based fluorescent probe (ATC-Hg) was designed and synthesized via the "covalent assembly" principle, which exhibited excellent selectivity and high sensitivity for Hg2+ and CH3Hg+. Moreover, it is the first Hg(ii) sensitive fluorescent probe that has been successfully applied in imaging in both cells and Escherichia coli.
April 27, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29695236/associations-between-comorbidities-their-treatment-and-survival-in-patients-with-interstitial-lung-diseases-a-claims-data-analysis
#17
Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with various ILDs remain sparse. METHODS: Using longitudinal claims data from a German Statutory Health Insurance Fund, we assessed comorbidity in ILD subtypes and associated drug treatments. Baseline comorbidity was assessed via the Elixhauser Comorbidity Index that was amended by ILD-relevant conditions...
April 25, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29687286/the-brca1-and-brca2-genes-in-early-onset-breast-cancer-patients
#18
Mohamed Saleem, Mohd Bazli Ghazali, Md Azlan Mohamed Abdul Wahab, Narazah Mohd Yusoff, Hakimah Mahsin, Ch'ng Ewe Seng, Imran Abdul Khalid, Mohd Nor Gohar Rahman, Badrul Hisham Yahaya
Approximately 5-10% of breast cancers are attributable to genetic susceptibility. Mutations in the BRCA1 and BRCA2 genes are the best known genetic factors to date. The goal of this study was to determine the structure and distribution of haplotypes of the BRCA1 and BRCA2 genes in early-onset breast cancer patients. We enrolled 70 patients diagnosed with early-onset breast cancer. A total of 21 SNPs (11 on BRCA1 and 10 on BRCA2) and 1 dinucleotide deletion on BRCA1 were genotyped using nested allele-specific PCR methods...
April 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29687032/enhanced-expression-of-anti-cd19-chimeric-antigen-receptor-in-piggybac-transposon-engineered-t-cells
#19
Daisuke Morita, Nobuhiro Nishio, Shoji Saito, Miyuki Tanaka, Nozomu Kawashima, Yusuke Okuno, Satoshi Suzuki, Kazuyuki Matsuda, Yasuhiro Maeda, Matthew H Wilson, Gianpietro Dotti, Cliona M Rooney, Yoshiyuki Takahashi, Yozo Nakazawa
Adoptive T cell therapy using chimeric antigen receptor (CAR)-modified T cells is a promising cancer immunotherapy. We previously developed a non-viral method of gene transfer into T cells using a piggyBac transposon system to improve the cost-effectiveness of CAR-T cell therapy. Here, we have further improved our technology by a novel culture strategy to increase the transfection efficiency and to reduce the time of T cell manufacturing. Using a CH2CH3-free CD19-specific CAR transposon vector and combining irradiated activated T cells (ATCs) as feeder cells and virus-specific T cell receptor (TCR) stimulation, we achieved 51...
March 16, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#20
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
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