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https://www.readbyqxmd.com/read/29349283/is-self-rated-health-in-adolescence-a-predictor-of-prescribed-medication-in-adulthood-findings-from-the-nord-tr%C3%A3-ndelag-health-study-and-the-norwegian-prescription-database
#1
Tina Lokke Vie, Karl Ove Hufthammer, Turid Lingaas Holmen, Eivind Meland, Hans Johan Breidablik
Self-rated health (SRH) is a commonly used health indicator predicting morbidity and mortality in a range of populations. However, the relationship between SRH and medication is not well established. The aim of this study was to examine adolescent SRH as a predictor for prescribed medication later in young adulthood. Eighteen years' prospective data from the Nord-Trøndelag Health Study (HUNT) and the Norwegian Prescription Database (NorPD) were analyzed. Baseline data, gathered from 8982 adolescents (mean age 16...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29347939/prevalence-and-management-of-severe-asthma-in-primary-care-an-observational-cohort-study-in-sweden-pacehr
#2
Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson, Christer Janson
BACKGROUND: Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increases disease burden. The objective of the study was to describe the prevalence and managemant of severe asthma in a Swedish asthma popuöation. METHODS: In this observational cohort study, primary care medical records data (2006-2013) from 36 primary health care centers were linked to data from national mandatory Swedish health registries...
January 18, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29344218/atra-increases-iodine-uptake-and-inhibits-the-proliferation-and-invasiveness-of-human-anaplastic-thyroid-carcinoma-sw1736-cells-involvement-of-%C3%AE-catenin-phosphorylation-inhibition
#3
Ling Lan, Spyros Basourakos, Dai Cui, Xuemei Zuo, Wei Deng, Lili Huo, Hailing Chen, Guoying Zhang, Lili Deng, Bingyin Shi, Yong Luo
All-trans-retinoic acid (ATRA) can enhance iodine uptake capability of thyroid tumors, but the mechanisms remain poorly understood. The aim of the present study was to investigate the effects of ATRA on isotope susceptibility, proliferation and invasion of anaplastic thyroid carcinoma (ATC) and potential mechanisms. SW1736 cells were treated with 1 µmol/l ATRA or 1% ethanol for 5 days. A cell line stably expressing β-catenin-shRNA was established. An iodine uptake assay was performed using 125I. Proliferation and invasiveness were tested using MTT and Transwell assays, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29334237/safety-of-working-patterns-among-uk-neuroradiologists-what-can-we-learn-from-the-aviation-industry-and-cognitive-science
#4
John Reicher, Stuart Currie, Daniel Birchall
As the volume and complexity of imaging in the UK continues to rise, there is pressure on radiologists to spend increasing lengths of time reporting to cope with the growing workload. However, there is limited guidance for radiologists about structuring the working day to achieve the necessary balance between satisfactory reporting volume and maintaining quality and safety. We surveyed 86 Neuroradiologists (receiving 59 responses), regarding time spent reporting, frequency and duration of work breaks, and break activities...
January 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29331886/anti-cancer-effects-of-hnha-and-lenvatinib-by-the-suppression-of-emt-mediated-drug-resistance-in-cancer-stem-cells
#5
Yong Sang Lee, Seok-Mo Kim, Bup-Woo Kim, Ho Jin Chang, Soo Young Kim, Cheong Soo Park, Ki Cheong Park, Hang-Seok Chang
Anaplastic thyroid cancer (ATC) constitutes less than 2% of total thyroid cancers but accounts for 20-40% of thyroid cancer-related deaths. Cancer stem cell drug resistance represents a primary factor hindering treatment. This study aimed to develop targeted agents against thyroid malignancy, focusing on individual and synergistic effects of HNHA (histone deacetylase), lenvatinib (FGFR), and sorafenib (tyrosine kinase) inhibitors. Patients with biochemically and histologically proven papillary thyroid cancer (PTC) and ATC were included...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29328392/targeting-bladder-cancer-using-activated-t%C3%A2-cells-armed-with-bispecific-antibodies
#6
Juan Ma, Jing Ge, Xin Xue, Weigang Xiu, Pan Ma, Ximing Sun, Man Zhang
In the present study, we aimed to investigate whether EGFR or HER2 may serve as a target for T cell-mediated immunotherapy against human bladder cancer. Expression of EGFR and HER2 was detected on the surface of bladder cancer cells, including Pumc-91 and T24 cells, and their chemotherapeutic drug-resistant counterparts. Activated T cells (ATCs) were generated from healthy PBMCs that were stimulated by the combination of anti-CD3 monoclonal antibody and anti‑CD28 monoclonal antibody in the presence of interleukin-2 for 14 days...
January 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29319130/anaplastic-thyroid-carcinoma-with-rapid-thyrotoxicosis-case-report-and-the-review-of-literature
#7
Jacek Daroszewski, Katarzyna Paczkowska, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski, Michał Jeleń
INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of malignant neoplasms of thyroid. ATC usually presents with local symptoms due to rapidly enlarging thyroid mass, and has only seldom been reported to be a cause of thyrotoxicosis. Up to date only 9 cases of ATC presented with thyrotoxicosis have been described. CASE REPORT: We report a case of 66-year-old woman, who had had a large, euthyroid multinodular goiter for almost 50 years...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29306020/a-selective-cyclin-dependent-kinase-4-6-dual-inhibitor-ribociclib-lee011-inhibits-cell-proliferation-and-induces-apoptosis-in-aggressive-thyroid-cancer
#8
Hyun Joo Lee, Woo Kyung Lee, Chan Woo Kang, Cheol Ryong Ku, Yoon Hee Cho, Eun Jig Lee
The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects of a selective CDK 4/6 inhibitor, Ribociclib (LEE011), in thyroid cancer. Performing Western blotting, we found that RB phosphorylation and the expression of Cyclin D are significantly higher in papillary thyroid cancer (PTC) cell lines as well as anaplastic thyroid cancer (ATC) cell lines, compared with normal thyroid cell line and follicular thyroid cancer cell line...
January 3, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29303800/prescribing-trends-of-atypical-antipsychotic-drugs-in-an-outpatient-unit-of-a-child-and-adolescent-clinic-in-turkey
#9
Çiğdem Yektaş, Ali Evren Tufan
OBJECTIVE: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics. METHOD: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment...
January 5, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29301825/genomic-correlates-of-response-to-everolimus-in-aggressive-radioiodine-refractory-thyroid-cancer-a-phase-ii-study
#10
Glenn J Hanna, Naifa L Busaidy, Nicole G Chau, Lori J Wirth, Justine A Barletta, Antonio Calles, Robert I Haddad, Stefan Kraft, Maria E Cabanillas, Guilherme Rabinowits, Anne O'Neill, Sewanti A Limaye, Erik K Alexander, Francis D Moore, Krzysztof Misiukiewicz, Tom Thomas, Matthew A Nehs, Ellen Marqusee, Stephanie L Lee, Pasi A Janne, Jochen H Lorch
PURPOSE: Targeting mutations leading to PI3K/mTOR/Akt activation are of interest in thyroid cancer (TC). We evaluated the efficacy of everolimus in aggressive, radioactive iodine refractory (RAIR) TC and correlated tumor mutational profiling with response. Exploratory medullary and anaplastic TC cohorts were included. EXPERIMENTAL DESIGN: This single-arm, multi-institutional phase II study was conducted from 2009-2013 in patients with incurable RAIR TC who had radiographic progression six months prior to enrollment...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29295821/anaplastic-thyroid-carcinoma-review-of-treatment-protocols
#11
Vera Tiedje, Martin Stuschke, Frank Weber, Henning Dralle, Laura Moss, Dagmar Führer
Anaplastic thyroid carcinoma (ATC) is an orphan disease and in most patients fatal. So far no established treatment is available that prolongs survival. Several large retrospective studies have identified negative prognostic markers, analyzed efficacy of multimodal approaches such as radiotherapy with and without concurrent chemotherapy and chemotherapy protocols. Recently, single case reports have suggested some effectiveness of newer therapies targeting single somatic alterations in ATC. All in all, the conclusions that can be drawn from published retrospective studies and the scarce prospective approaches is that new treatment protocols should be developed including surgery, radiotherapy, chemotherapy and targeted therapy approaches and combinational therapy with immunotherapies...
January 2, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29285499/prediction-models-to-advance-individualized-resuscitation-in-trauma-hemorrhage-and-acute-traumatic-coagulopathy-atc-even-the-longest-journey-starts-with-first-steps-lao-tzu-chinese-philosopher
#12
EDITORIAL
https://www.readbyqxmd.com/read/29285201/effects-of-hur-downregulation-on-anaplastic-thyroid-cancer-cells
#13
Lorenzo Allegri, Catia Mio, Diego Russo, Sebastiano Filetti, Federica Baldan
Anaplastic thyroid cancer (ATC) constitutes one of the most aggressive types of human solid cancer, and is characterized by the absence of thyroid differentiation features and a marked degree of invasiveness. We have previously demonstrated that the RNA-binding protein Hu antigen R (HuR) is overexpressed in thyroid carcinoma; thus, the biological role of this RNA-binding protein was investigated in the present study using the ATC cell lines SW1736 and 8505C. In both cell lines, HuR protein levels were higher compared with in the non-tumorigenic thyroid cell line Nthy-ori-3...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29278866/is-patient-exposure-preapproval-and-postapproval-a-determinant-of-the-timing-and-frequency-of-occurrence-of-safety-issues
#14
Alexandra C Pacurariu, Christina E Hoeve, Peter Arlett, Georgy Genov, Jim Slattery, Miriam C J M Sturkenboom, Sabine M J M Straus
BACKGROUND: The amount of drug exposure, pre and post approval, is considered to be a direct determinant of knowledge about the safety of a drug. A larger pre-approval exposed population is supposed to reduce the risk of unanticipated safety issues post-approval. The amount of use in the postapproval population is also expected to influence the occurrence and timing of safety issues. We investigated how the amount of pre and post approval exposure influences the detection of post-approval safety issues...
December 26, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29278494/synthesis-of-allylic-alcohols-via-cu-catalyzed-hydrocarbonylative-coupling-of-alkynes-with-alkyl-halides
#15
Li-Jie Cheng, Shahidul M Islam, Neal P Mankad
We have developed a modular procedure to synthesize allylic alcohols by coupling alkynes with CO and tertiary, secondary, or primary alkyl halides via a Cu-catalyzed hydrocarbonylative coupling and 1,2-reduction tandem sequence. The initial use of tertiary alkyl halides as electrophiles was found to enable synthesis of various allylic alcohols bearing -quaternary carbon centers in good yield with high 1,2-reduction selectivity. Mechanistic studies suggested a different pathway was operative with tertiary alkyl halides compared to primary and secondary alkyl halides for generating the key copper(III) oxidative ad-duct...
December 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29277174/characteristics-of-managed-entry-agreements-in-australia
#16
Maxine F Robinson, Cathrine Mihalopoulos, Tracy Merlin, Elizabeth Roughead
OBJECTIVES: Australia relies on managed entry agreements (MEAs) for many medicines added to the national Pharmaceutical Benefits Scheme (PBS). Previous studies of Australian MEAs examined public domain documents and were not able to provide a comprehensive assessment of the types and operation of MEAs. This study used government documents approved for release to examine the implementation and administration of MEAs implemented January 2012 to May 2016. METHODS: We accessed documents for medicines with MEAs on the PBS between January 2012 and May 2016...
December 26, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29275295/ezh2-overexpression-as-a-useful-prognostic-marker-for-aggressive-behaviour-in-thyroid-cancer
#17
Katsuhiko Masudo, Nobuyasu Suganuma, Hirotaka Nakayama, Takashi Oshima, Yasushi Rino, Hiroyuki Iwasaki, Kenichi Matsuzu, Kiminori Sugino, Koichi Ito, Tetsuo Kondo, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Munetaka Masuda, Yohei Miyagi
BACKGROUND/AIM: Enhancer of zeste homolog 2 (EZH2) is a member of the polycomb group of genes, which are key factors in the regulation of cell proliferation and differentiation. EZH2 is overexpressed in many malignancies. We analyzed EZH2 protein expression levels in different histological subtypes of thyroid cancer to examine its utility as a prognostic factor. MATERIALS AND METHODS: We examined EZH2 protein expression by immunohistochemistry in tissue samples from 67 cases of poorly differentiated (PDTC) and 48 cases of anaplastic thyroid carcinoma (ATC), and in samples of adjacent normal and differentiated thyroid carcinoma (DTC)...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29275174/postanoxic-alpha-theta-or-alpha-theta-coma-clinical-setting-and-neurological-outcome
#18
José L Fernández-Torre, Anjana López-Delgado, Miguel A Hernández-Hernández, Alicia Paramio-Paz, Carla Pía-Martínez, Pedro Orizaola, María Martín-García
AIM: The aim of this study was to determine the prognosis of 26 consecutive adults with alpha coma (AC), theta coma (TC) or alpha-theta coma (ATC) following CRA and to describe the clinical setting and EEG features of these patients. METHODS: We retrospective analyzed a prospectively collected cohort of adult patients diagnosed as having AC, TC or ATC after CRA between January 2008 and June 2016. None of patients included in this analysis underwent therapeutic hypothermia (TH)...
December 21, 2017: Resuscitation
https://www.readbyqxmd.com/read/29251329/bet-bromodomain-inhibitor-jq1-modulates-microrna-expression-in-thyroid-cancer-cells
#19
Catia Mio, Ketty Conzatti, Federica Baldan, Lorenzo Allegri, Marialuisa Sponziello, Francesca Rosignolo, Diego Russo, Sebastiano Filetti, Giuseppe Damante
Anaplastic thyroid carcinoma (ATC) represents the most lethal thyroid cancer sub-type, currently unresponsive to standard treatments. Recently, bromodomain and extra-terminal (BET) proteins have emerged as attractive therapeutic targets in several diseases, including cancer. In different cancer models, the anti-neoplastic activity of BET inhibitors such as JQ1, I-BET762 and I-BET151 have already been established, due to both direct and indirect effects. miRNAs are 20-22 nucleotide transcriptional regulators which play important roles in proliferation, differentiation and apoptosis...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29247833/inferring-anatomical-therapeutic-chemical-atc-class-of-drugs-using-shortest-path-and-random-walk-with-restart-algorithms
#20
Lei Chen, Tao Liu, Xian Zhao
The anatomical therapeutic chemical (ATC) classification system is a widely accepted drug classification scheme. This system comprises five levels and includes several classes in each level. Drugs are classified into classes according to their therapeutic effects and characteristics. The first level includes 14 main classes. In this study, we proposed two network-based models to infer novel potential chemicals deemed to belong in the first level of ATC classification. To build these models, two large chemical networks were constructed using the chemical-chemical interaction information retrieved from the Search Tool for Interactions of Chemicals (STITCH)...
December 13, 2017: Biochimica et Biophysica Acta
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