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https://www.readbyqxmd.com/read/28924472/the-effect-of-antibiotic-use-on-prevalence-of-nosocomial-vancomycin-resistant-enterococci-an-ecologic-study
#1
Cornelius Remschmidt, Michael Behnke, Axel Kola, Luis A Peña Diaz, Anna M Rohde, Petra Gastmeier, Frank Schwab
BACKGROUND: Vancomycin-resistant enterococci (VRE) are among the most common antimicrobial-resistant pathogens causing nosocomial infections. Although antibiotic use has been identified as a risk factor for VRE, it remains unclear which antimicrobial agents particularly facilitate VRE selection. Here, we assessed whether use of specific antimicrobial agents is independently associated with healthcare-associated (HA) VRE rates in a university hospital setting in Berlin, Germany. METHODS: We conducted the study between January 2014 and December 2015 at the Charité-university hospital of Berlin, Germany...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28921834/the-role-of-pre-morbid-diabetes-on-developing-amyotrophic-lateral-sclerosis
#2
Fabrizio D'Ovidio, Angelo d'Errico, Paolo Carnà, Andrea Calvo, Giuseppe Costa, Adriano Chiò
BACKGROUND: The literature on the association between diabetes and Amyotrophic Lateral Sclerosis (ALS) counts a limited number of studies. This cohort study was developed in order to assess the role of diabetes on the risk of developing ALS. METHODS: The study population was represented by all residents in Turin (Italy) at the beginning of 1996, already present at 1991 Census, older than 14 years (n=727,977), followed up for ALS occurrence from 1998 to 2014. Presence of diabetes at baseline or during the follow-up was ascertained through two Piedmont regional sources: the Diabetes Registry and the ATC Drugs Prescriptions Archive...
September 18, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28920531/role-of-kr%C3%A3-ppel-like-factor-4-in-the-maintenance-of-chemoresistance-of-anaplastic-thyroid-cancer
#3
Su In Lee, Dae Kyoung Kim, Eun Jin Seo, Eun Jung Choi, Yang Woo Kwon, Il Ho Jang, Jin Choon Lee, Hyun Yul Kim, Minho Shong, Jae Ho Kim, Seong-Jang Kim
BACKGROUND: Anaplastic thyroid cancer (ATC) has a very poor prognosis due to its aggressive nature and resistance to conventional treatment. Radiotherapy and chemotherapy are not fully effective because of the undifferentiated phenotype and enhanced drug resistance of ATC. The objective of this study was to evaluate the involvement of Krüppel-like factor 4 (KLF4), a stemness-associated transcription factor, in the undifferentiated phenotype and drug resistance of ATC. METHODS: ATC cells were compared with papillary thyroid cancer cells in drug resistance and gene expression...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28920070/prevalence-and-associated-factors-of-acute-traumatic-coagulopathy-a-cross-sectional-study
#4
Hojjat Derakhshanfar, Ali Vafaei, Ali Tabatabaey, Shamila Noori
INTRODUCTION: Acute traumatic coagulopathy (ATC) is defined as having evidence of coagulopathy in patients with severe trauma. The aim of this preliminary study was to assess the prevalence and associated factors of ATC in severely traumatic patients presenting to emergency department (ED). METHODS: In this retrospective cross sectional study, all patients with severe traumatic injury and available coagulation profile, presenting to the EDs of two major trauma centers in Tehran, Iran, during one year, were studied...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28913333/utilization-of-parenteral-morphine-by-application-of-atc-ddd-methodology-retrospective-study-in-the-referral-teaching-hospital
#5
Viktorija Dragojevic-Simic, Nemanja Rancic, Dusica Stamenkovic, Radoje Simic
BACKGROUND: Few studies analyzed the pattern of opioid analgesic utilization in hospital settings. The aim of this study was to determine the consumption pattern of parenteral morphine in patients hospitalized in the Serbian referral teaching hospital and to correlate it with utilization at the national and international level. METHODS: In retrospective study, the required data were extracted from medical records of surgical patients who received parenteral morphine in the 5-year period, from 2011 to 2015...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28892908/cytological-diagnosis-of-an-uncommon-high-grade-malignant-thyroid-tumour-a-case-report
#6
Ruchi Nagpal, Manju Kaushal, Sawan Kumar
Anaplastic Thyroid Carcinoma (ATC) is a relatively uncommon highly malignant tumour originating from the follicular cells of thyroid gland having poor prognosis. It accounts for 2% to 5% of all thyroid carcinomas and patients typically present with a rapidly growing anterior neck mass with aggressive symptoms. A 53-year-old male presented with diffuse neck swelling measuring 8x6 cm and right cervical lymph node measuring 2x2 cm since one month which was associated with dyspepsia and dyspnoea. Ultrasound and Contrast Enhanced Computed Tomography (CECT) neck revealed enlarged right lobe of thyroid and multiple enlarged cervical lymph nodes with soft tissue density nodules in bilateral lungs...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28883024/hearing-threshold-shifts-among-military-pilots-of-the-israeli-air-force
#7
Liyona Kampel-Furman, Z Joachims, H Bar-Cohen, A Grossman, Y Frenkel-Nir, Y Shapira, E Alon, E Carmon, B Gordon
BACKGROUND: Military aviators are potentially at risk for developing noise-induced hearing loss. Whether ambient aircraft noise exposure causes hearing deficit beyond the changes attributed to natural ageing is debated. The aim of this research was to assess changes in hearing thresholds of Israeli Air Force (IAF) pilots over 20 years of military service and identify potential risk factors for hearing loss. METHODS: A retrospective cohort analysis was conducted of pure-tone air conduction audiograms of pilots, from their recruitment at 18 years of age until the last documented medical check-up...
September 6, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28881369/-molecular-pathogenesis-of-thyroid-nodules-relevance-for-clinical-care
#8
D Führer, T Musholt, K W Schmid
Thyroid nodules represent heterogeneous tumors with distinct molecular signatures. While benign thyroid nodules correspond to poly- or monoclonal tumors, thyroid carcinomas are monoclonal and thus "real" neoplasms. These are caused by somatic mutations that lead to the constitutive activation of specific signaling cascades and determine the corresponding histology and also partly the functional phenotype of the thyroid tumor. Dedifferentiation of thyroid carcinomas is accompanied by the occurrence of additional mutations in the tumors...
September 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28880449/reduced-risk-of-decompensation-and-death-associated-with-use-of-statins-in-patients-with-alcoholic-cirrhosis-a-nationwide-case-cohort-study
#9
U C Bang, T Benfield, F Bendtsen
BACKGROUND: Reports have indicated that the use of statins may ameliorate the course of cirrhosis. AIM: To determine the relationship between use of statins and mortality rate in patients with cirrhosis. METHODS: We did a retrospective case-cohort analysis based on data from the Danish registers from the period 1995 through 2014. Index date was time of diagnosis of cirrhosis (ICD-10: K703) and cohort entry depended on whether the patient was statin user or not...
October 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28875621/rare-manifestations-of-anaplastic-thyroid-carcinoma-the-role-of-braf-mutation-analysis
#10
Young Shin Song, Chan Kwon Jung, Kyeong Cheon Jung, Young Joo Park, Jae Kyung Won
Anaplastic thyroid carcinoma (ATC) is difficult to distinguish from other cancers, especially when its pathological features are atypical for ATC or when the tumor is totally undifferentiated and occurs after a considerable lapse of time, in an area remote from the original site of the tumor. Here, we present two patients (68-year-old man and 56-year-old woman) with rare manifestations of ATC, which were initially thought to be other malignancies. Immunohistochemical tests, using various markers, failed to provide information about the origin of these tumors...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28860443/-efficacy-and-safety-of-lenvatinib-for-unresectable-anaplastic-thyroid-cancer
#11
Haruhiko Yamazaki, Satoru Shimizu, Hiroyuki Iwasaki, Tatsuya Yoshida, Nobuyasu Suganuma, Takashi Yamanaka, Izumi Kojima, Katsuhiko Masudo, Soji Toda, Hirotaka Nakayama, Munetaka Masuda
The 208 trial showed that lenvatinib has a significant antitumor effect on unresectable anaplastic thyroid cancer(ATC). Herein, we present a retrospective review of data from 7 patients with unresectable ATC who received lenvatinib in our hospital between May 2015 and October 2016. Two patients were men and 5 were women. The median age was 78(range, 72-85)years, and 1 patient had Stage IV A disease, 1 had Stage IV B, and 5 had Stage IV C at diagnosis, respectively. Three patients experienced a partial response and 1 patient experienced stable disease...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28859277/absolute-quantification-of-aggregatibacter-actinomycetemcomitans-in-patients-carrying-haplotypes-associated-with-susceptibility-to-chronic-periodontitis-multifaceted-evaluation-with-periodontitis-covariants
#12
Thamiris Cirelli, Livia S Finoti, Sâmia C T Corbi, Giovana Anovazzi, Rafael Nepomuceno, Silvana R P Orrico, Joni A Cirelli, Márcia P A Mayer, Raquel M Scarel-Caminaga
This study aimed to evaluate the association between haplotypes in the interleukin 8 (IL8) and IL4 genes previously associated to chronic periodontitis (CP) and the levels of Aggregatibacter actinomycetemcomitans (A.a.) in subgingival sites of patients with and without CP. Moreover, multifaceted evaluations were made to search associations among patients' genetic background with the A.a. levels and previous clinical/immunological/microbiological findings. Subgingival sites (n = 596) of 104 patients were divided into susceptible to CP by the IL8 haplotype ATC/TTC (IL8+); non-susceptible to CP by the IL8 AGT/TTC (IL8-); susceptible to CP by the IL4 TCI/CCI (IL4+); protection against CP by the IL4 TTD/CTI (IL4-)...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28852098/selinexor-kpt-330-has-antitumor-activity-against-anaplastic-thyroid-carcinoma-in-vitro-and-in-vivo-and-enhances-sensitivity-to-doxorubicin
#13
Manoj Garg, Deepika Kanojia, Anand Mayakonda, Trivadi S Ganesan, Bindhya Sadhanandhan, Sidhanth Suresh, Sneha S, Rohit P Nagare, Jonathan W Said, Ngan B Doan, Ling-Wen Ding, Erkan Baloglu, Sharon Shacham, Michael Kauffman, H Phillip Koeffler
Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined the therapeutic potential of selinexor (XPO1 inhibitor) against human ATC cells both in vitro and in vivo. Here, we showed that XPO1 is robustly expressed in primary ATC samples and human ATC cell lines. Silencing of XPO1 by either shRNA or selinexor significantly reduced cellular growth and induced cell cycle arrest, apoptosis of ATC cells by altering the protein expression of cancer-related genes...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844141/discovery-and-optimization-of-5-amino-1-2-3-triazole-4-carboxamide-series-against-trypanosoma-cruzi
#14
Stephen Brand, Eun Jung Ko, Elisabet Viayna, Stephen Thompson, Daniel Spinks, Michael Thomas, Lars Sandberg, Amanda F Francisco, Shiromani Jayawardhana, Victoria C Smith, Chimed Jansen, Manu De Rycker, John Thomas, Lorna MacLean, Maria Osuna-Cabello, Jennifer Riley, Paul Scullion, Laste Stojanovski, Frederick R C Simeons, Ola Epemolu, Yoko Shishikura, Sabrinia D Crouch, Tania S Bakshi, Christopher J Nixon, Iain H Reid, Alan P Hill, Tim Z Underwood, Sean J Hindley, Sharon A Robinson, John M Kelly, Jose M Fiandor, Paul G Wyatt, Maria Marco, Timothy J Miles, Kevin D Read, Ian H Gilbert
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent need for new safer treatments because current standard therapeutic options, benznidazole and nifurtimox, have significant side effects and are only effective in the acute phase of the infection with limited efficacy in the chronic phase. Phenotypic high content screening against the intracellular parasite in infected VERO cells was used to identify a novel hit series of 5-amino-1,2,3-triazole-4-carboxamides (ATC)...
September 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28844117/well-differentiated-thyroid-cancer-neovasculature-expresses-prostate-specific-membrane-antigen-a-possible-novel-therapeutic-target
#15
Maureen Moore, Suraj Panjwani, Rashmi Mathew, Michael Crowley, Yi-Fang Liu, Anna Aronova, Brendan Finnerty, Rasa Zarnegar, Thomas J Fahey, Theresa Scognamiglio
Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein receptor, is highly expressed in prostate cancer and in the tumor neovasculature of colon, breast, and adrenocortical tumors. Here, we analyzed PSMA expression in the neovasculature of various thyroid cancer subtypes and assessed whether PSMA expression is correlated with aggressive behavior. From a prospectively maintained database, we evaluated 91 samples from 68 patients, including 37 primary differentiated thyroid cancers (DTCs) [11 classic papillary (cPTC), 9 follicular-variant (FvPTC), 11 follicular (FTC), 6 radioactive iodine-refractory (RAIR)], 5 anaplastic (ATC) carcinomas, 9 distant and 12 lymph node metastases, 21 benign thyroid nodules, and 7 normal thyroid specimens...
August 26, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28843268/effects-of-a-phosphoinositide-3-kinase-inhibitor-on-anaplastic-thyroid-cancer-stem-cells
#16
Farzaneh Bozorg-Ghalati, Mehdi Hedayati, Mehdi Dianatpour, Fereidoun Azizi, Nariman Mosaffa, Davood Mehrabani
Background: Thyroidectomy, radioactive iodine therapy, chemotherapy, or their combination are treatments of choice for thyroid cancers. However, cancer stem cells (CSCs) may become resistant to therapy, and mutations in somatic genes affect radioiodine uptake. This study determined the effect of a phosphoinositide-3-kinase (PI3K) inhibitor on anaplastic thyroid CSCs. Materials and Methods: The magnetic-activated cell sorting assay was used for segregating CD133-positive CSCs from three anaplastic thyroid carcinoma (ATC) cell lines (C643, SW1736, and 8305C)...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28836222/the-implementation-of-managed-entry-agreements-in-central-and-eastern-europe-findings-and-implications
#17
Alessandra Ferrario, Diāna Arāja, Tomasz Bochenek, Tarik Čatić, Dávid Dankó, Maria Dimitrova, Jurij Fürst, Ieva Greičiūtė-Kuprijanov, Iris Hoxha, Arianit Jakupi, Erki Laidmäe, Olga Löblová, Ileana Mardare, Vanda Markovic-Pekovic, Dmitry Meshkov, Tanja Novakovic, Guenka Petrova, Maciej Pomorski, Dominik Tomek, Luka Voncina, Alan Haycox, Panos Kanavos, Patricia Vella Bonanno, Brian Godman
BACKGROUND: Managed entry agreements (MEAs) are a set of instruments to facilitate access to new medicines. This study surveyed the implementation of MEAs in Central and Eastern Europe (CEE) where limited comparative information is currently available. METHOD: We conducted a survey on the implementation of MEAs in CEE between January and March 2017. RESULTS: Sixteen countries participated in this study. Across five countries with available data on the number of different MEA instruments implemented, the most common MEAs implemented were confidential discounts (n = 495, 73%), followed by paybacks (n = 92, 14%), price-volume agreements (n = 37, 5%), free doses (n = 25, 4%), bundle and other agreements (n = 19, 3%), and payment by result (n = 10, >1%)...
August 23, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28832898/spontaneous-breathing-trials-after-prolonged-mechanical-ventilation-monitored-by-electrical-impedance-tomography-an-observational-study
#18
Z Zhao, S-Y Peng, M-Y Chang, Y-L Hsu, I Frerichs, H-T Chang, K Möller
BACKGROUND: The study objective was to examine the correlation between regional ventilation distribution measured with electrical impedance tomography (EIT) and weaning outcomes during spontaneous breathing trial (SBT). METHODS: Fifteen patients received 100% automatic tube compensation (ATC) during the first and 70% during the second hour. Another 15 patients received external continuous positive airway pressure (CPAP) of 5 and 7.5 cmH2 O during the first and second hours, respectively...
August 17, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28829399/current-advances-in-thyroid-cancer-management-are-we-ready-for-the-epidemic-rise-of-diagnoses
#19
REVIEW
Dagmara Rusinek, Ewa Chmielik, Jolanta Krajewska, Michal Jarzab, Malgorzata Oczko-Wojciechowska, Agnieszka Czarniecka, Barbara Jarzab
A rising incidence of thyroid cancers (TCs) mainly small tumors, observed during recent years, lead to many controversies regarding treatment strategies. TCs represent a distinct molecular background and clinical outcome. Although in most cases TCs are characterized by a good prognosis, there are some aggressive forms, which do not respond to standard treatment. There are still some questions, which have to be resolved to avoid dangerous simplifications in the clinical management. In this article, we focused on the current advantages in preoperative molecular diagnostic tests and histopathological examination including noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)...
August 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28820894/short-term-apparent-brain-tissue-changes-are-contributed-by-cerebral-blood-flow-alterations
#20
Qiu Ge, Wei Peng, Jian Zhang, Xuchu Weng, Yong Zhang, Thomas Liu, Yu-Feng Zang, Ze Wang
Structural MRI (sMRI)-identified tissue "growth" after neuropsychological training has been reported in many studies but the origins of those apparent tissue changes (ATC) still remain elusive. One possible contributor to ATC is brain perfusion since T1-weighted MRI, the tool used to identify ATC, is sensitive to perfusion-change induced tissue T1 alterations. To test the hypothetical perfusion contribution to ATC, sMRI data were acquired before and after short-term global and regional perfusion manipulations via intaking a 200 mg caffeine pill and performing a sensorimotor task...
2017: PloS One
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