Arbor G Dykema, Jiajia Zhang, Laurene S Cheung, Sydney Connor, Boyang Zhang, Zhen Zeng, Christopher M Cherry, Taibo Li, Justina X Caushi, Marni Nishimoto, Andrew J Munoz, Zhicheng Ji, Wenpin Hou, Wentao Zhan, Dipika Singh, Tianbei Zhang, Rufiaat Rashid, Marisa Mitchell-Flack, Sadhana Bom, Ada Tam, Nick Ionta, Thet H K Aye, Yi Wang, Camille A Sawosik, Lauren E Tirado, Luke M Tomasovic, Derek VanDyke, Jamie B Spangler, Valsamo Anagnostou, Stephen Yang, Jonathan Spicer, Roni Rayes, Janis Taube, Julie R Brahmer, Patrick M Forde, Srinivasan Yegnasubramanian, Hongkai Ji, Drew M Pardoll, Kellie N Smith
Regulatory T cells (Treg ) are conventionally viewed as suppressors of endogenous and therapy-induced antitumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integrated single-cell RNA-seq/T cell receptor sequencing (TCRseq) of >73,000 tumor-infiltrating Treg (TIL-Treg ) from anti-PD-1-treated and treatment-naive non-small cell lung cancers (NSCLC) with single-cell analysis of tumor-associated antigen (TAA)-specific Treg derived from a murine tumor model...
September 15, 2023: Science Immunology