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https://www.readbyqxmd.com/read/27847359/human-asymptomatic-epitopes-identified-from-the-herpes-simplex-virus-tegument-protein-vp13-14-ul47-preferentially-recall-polyfunctional-effector-memory-cd44highcd62llowcd8-tem-cells-and-protect-humanized-hla-a-02-01-transgenic-mice-against-ocular-herpes
#1
Ruchi Srivastava, Arif A Khan, Sumit Garg, Sabrina A Syed, Julie N Furness, Hawa Vahed, Tiffany Pham, Howard T Yu, Anthony B Nesburn, Lbachir BenMohamed
: The herpes simplex virus type 1 (HSV-1) infection is widespread among humans. The HSV-1 virion protein 13/14 (VP13/14), also known as UL47, is a tegument antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether VP13/14-specific CD8(+) T cells play a role in the "natural protection" seen in asymptomatic (ASYMP) individuals (have never had a clinical herpetic disease) has not been elucidated. Using predictive computer-assisted algorithms, we identified 10 potential HLA-A*02:01-restricted CD8(+) T cell epitopes from the 693 amino acids sequence of VP13/14 protein...
November 9, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27625431/cytokines-and-t-cell-homeostasis-in-hiv-infection
#2
Michael L Freeman, Carey L Shive, Thao P Nguyen, Souheil-Antoine Younes, Soumya Panigrahi, Michael M Lederman
Untreated human immunodeficiency virus (HIV) infection is characterized by progressive CD4(+) T-cell depletion and CD8(+) T-cell expansion, and CD4(+) T-cell depletion is linked directly to the risk for opportunistic infections and infection-associated mortality. With suppression of HIV replication by antiretroviral therapy, circulating CD4(+) Tcell numbers typically improve while CD8(+) T-cell expansion persists, and both CD4(+) T-cell cytopenia and CD8(+) T-cell expansion are associated with morbidity and mortality...
October 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27522716/-subpopulations-of-regulatory-t-lymphocytes-in-the-peripheral-blood-of-patients-with-rheumatoid-arthritis
#3
P N Kravchenko, G A Zhulai, A V Churov, E K Oleinik, V M Oleinik, O Yu Barysheva, N N Vezikova, I M Marusenko
BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory rheumatic disease associated with a dysfunction of the T cell-mediated tolerance and leading to the disability of working population. The regulatory CD4' T cells play an important role in the regulation of autoimmunity and can suppress immune responses. With that, there is no consensus on the content of these lymphocytes and their role in the pathogenesis of RA. Objective: The aim of the study was to assess the content ofperipheral blood regulatory Tcells (Treg) according to the expression of membrane markers CD4, CD25, CD127 and intracellular FOXP3 marker, as well as the expression of two functional molecules (CTLA-4 and CCR4) in Treg cells of patients with RA...
2016: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/27509944/incidence-and-management-of-toxicity-associated-with-lasparaginase-in-the-treatment-of-all-and-nk-tcell-lymphoma-an-observational-study
#4
Shu Hui Yeang, Alexandre Chan, Chuen Wen Tan, Soon Thye Lim, Heng Joo Ng
BACKGROUND: Lasparaginase (ASNase) is commonly used in the treatment of acute lymphoblastic leukemia (ALL) and natural killer (NK)/Tcell lymphoma. This study was designed to describe the incidence of toxicity associated with ASNase in Asian adults. Secondary objectives were to investigate the management and impact of toxicity on subsequent ASNase use, and to compare the actual management against current recommendations. MATERIALS AND METHODS: In this retrospective, multicenter, observational study, Asian patients ≥ 18 years old who received ≥ 1 dose of the native E...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27231509/t-cell-subset-profile-in-healthy-zambian-adults-at-the-university-teaching-hospital
#5
Caroline Cleopatra Chisenga, Paul Kelly
INTRODUCTION: Symptom-free human immunodeficiency virus antibody-negative Zambian adults (51 subjects, aged 20 to 62 years, 33.3% women and 66.7% men) were studied to establish T cell subset reference ranges. METHODS: We carried out across sectional study at the University Teaching Hospital, Lusaka. Blood samples were collected from healthy donor volunteers from hospital health care staff, between February and March 2015. Immunopheno typing was undertaken to characterize Tcell subsets using the markers CD3, CD4, CD8, α4β7, Ki67, CD25, CCR7, CD54RA, CD57, CD28, CD27 and HLA-DR...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27220625/gender-and-duration-of-disease-differentiate-responses-to-rituximab-dexamethasone-therapy-in-adults-with-immune-thrombocytopenia
#6
John Chapin, Christina S Lee, Haiyu Zhang, James L Zehnder, James B Bussel
Adults often develop chronic immune thrombocytopenia (ITP) for which treatment order is uncertain. Rituximab and three cycles of dexamethasone (4R + 3Dex) improve treatment responses and short-term disease control but long-term outcome is not known. In adults with ITP treated with 4R + 3D, we sought long-term outcome and associated prognostic variables. Forty-nine adults treated at Weill-Cornell received 4R + 3Dex. Their clinical characteristics were reviewed. Duration was median time to treatment failure; Kaplan-Meier estimates were developed...
September 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27217298/impact-of-human-mutant-tgf%C3%AE-1-fc-protein-on-memory-and-regulatory-t-cell-homeostasis-following-lymphodepletion-in-nonhuman-primates
#7
H Guo, L Lu, R Wang, A Perez-Gutierrez, H S Abdulkerim, A F Zahorchak, T L Sumpter, K A Reimann, A W Thomson, M B Ezzelarab
Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of a novel human mutant TGFβ1/Fc (human IgG4 Fc) fusion protein on memory CD4(+) and CD8(+) T cell (Tmem) responses in vitro and their recovery following antithymocyte globulin (ATG)-mediated lymphodepletion in monkeys. TGFβ1/Fc induced Smad2/3 protein phosphorylation in rhesus and human peripheral blood mononuclear cells and augmented the suppressive effect of rapamycin on rhesus Tmem proliferation after either alloactivation or anti-CD3/CD28 stimulation...
May 23, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27141390/improved-efficacy-of-mitoxantrone-in-patients-with-castration-resistant-prostate-cancer-after-vaccination-with-gm-csf-transduced-allogeneic-prostate-cancer-cells
#8
Joyce M van Dodewaard-de Jong, Saskia Jam Santegoets, Peter M van de Ven, Jurjen Versluis, Henk M W Verheul, Tanja D de Gruijl, Winald R Gerritsen, Alfons J M van den Eertwegh
Previous vaccination studies in patients with castration-resistant prostate cancer (CRPC) showed improved survival without prolongation of progression-free survival (PFS). This might be explained by enhanced efficacy of subsequent therapies because of heightened immune status. We therefore evaluated the efficacy of chemotherapy in CRPC patients after immunotherapy. We retrospectively analyzed 28 patients who were treated with ipilimumab and GVAX, an allogeneic vaccine, and 21 patients who were randomized to GVAX or no vaccination...
April 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27070448/targeting-pd-1-and-tim-3-pathways-to-reverse-cd8-t-cell-exhaustion-and-enhance-ex-vivo-t-cell-responses-to-autologous-dendritic-tumor-vaccines
#9
Jingwei Liu, Shurong Zhang, Yuefeng Hu, Zhaomin Yang, Jingpo Li, Xuesong Liu, Lijuan Deng, Yue Wang, Xiaoyan Zhang, Ting Jiang, Xu Lu
The paradoxical coexistence of spontaneous tumor antigen-specific immune response with progressive disease in cancer patients need to dissect the molecular pathways involved in tumor-induced T-cell dysfunction or exhaustion. Programmed cell death 1 (PD-1) has been identified as a marker of exhausted T cells in chronic disease states, and blockade of PD-1-PD-L1 interactions has been shown to partially restore T-cell function. We have found that T-cell immunoglobulin mucin (Tim) 3 is expressed on CD8+ tumor-infiltrating lymphocytes (TILs) isolated from patients with colorectal cancer...
May 2016: Journal of Immunotherapy
https://www.readbyqxmd.com/read/27007050/t-cells-conditioned-with-mdsc-show-an-increased-anti-tumor-activity-after-adoptive-t-cell-based-immunotherapy
#10
Patrick L Raber, Rosa A Sierra, Paul T Thevenot, Zhang Shuzhong, Dorota D Wyczechowska, Takumi Kumai, Esteban Celis, Paulo C Rodriguez
The success of adoptive T cell-based immunotherapy (ACT) in cancer is limited in part by the accumulation of myeloid-derived suppressor cells (MDSC), which block several T cell functions, including T cell proliferation and the expression of various cytotoxic mediators. Paradoxically, the inhibition of CD8+ T cell differentiation into cytotoxic populations increased their efficacy after ACT into tumor-bearing hosts. Therefore, we aimed to test the impact of conditioning CD8+ T cells with MDSC on their differentiation potential and ACT efficacy...
April 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/26772776/cannabidiol-limits-tcell-mediated-chronic-autoimmune-myocarditis-implications-to-autoimmune-disorders-and-organ-transplantation
#11
Wen-Shin Lee, Katalin Erdelyi, Csaba Matyas, Partha Mukhopadhyay, Zoltan V Varga, Lucas Liaudet, György Haskó, Daniela Čiháková, Raphael Mechoulam, Pal Pacher
RATIONALE: Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and adolescents. Many cases of myocarditis are associated with autoimmune processes in which cardiac myosin is a major autoantigen. Conventional immunosuppressive therapies often provide unsatisfactory results and are associated with adverse toxicities during the treatment of autoimmune myocarditis. Cannabidiol (CBD) is a non-psychoactive constituent of Marijuana which exerts antiinflammatory effects independent from classical cannabinoid receptors...
January 8, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/26707220/alterations-in-serotype-specific-b-cell-responses-to-the-13-valent-pneumococcal-conjugate-vaccine-in-aging-hiv-infected-adults
#12
Jennifer A Ohtola, Noor M Khaskhely, Jessica L Saul-Mcbeth, Anita S Iyer, David J Leggat, Sadik A Khuder, M A Julie Westerink
BACKGROUND: Advanced age and human immunodeficiency virus (HIV) infection are associated with increased pneumococcal disease risk. The impact of these factors on cellular responses to vaccination is unknown. METHODS: HIV-infected (HIV+) individuals 50-65 years old with CD4(+) Tcells/μl (CD4) >200 on antiretroviral therapy (ART) ≥1 year received either the 13-valent pneumococcal conjugate vaccine followed by the 23-valent pneumococcal polysaccharide vaccine (PCV/PPV) or PPV only...
January 20, 2016: Vaccine
https://www.readbyqxmd.com/read/26544051/discovery-of-genome-wide-microsatellite-markers-in-scombridae-a-pilot-study-on-albacore-tuna
#13
Natacha Nikolic, Stéphanie Duthoy, Antoine Destombes, Nathalie Bodin, Wendy West, Alexis Puech, Jérôme Bourjea
Recent developments in sequencing technologies and bioinformatics analysis provide a greater amount of DNA sequencing reads at a low cost. Microsatellites are the markers of choice for a variety of population genetic studies, and high quality markers can be discovered in non-model organisms, such as tuna, with these recent developments. Here, we use a high-throughput method to isolate microsatellite markers in albacore tuna, Thunnus alalunga, based on coupling multiplex enrichment and next-generation sequencing on 454 GS-FLX Titanium pyrosequencing...
2015: PloS One
https://www.readbyqxmd.com/read/26514007/-effect-of-dexamethasone-on-the-expression-of-tregs-in-allergic-rhinitis-mice
#14
Tingting Jiang, Weihua Wang, Zhenghua Zhu, Liwei Zhu, Zhaoxin Ma
OBJECTIVE: To investigate the effect of dxamethasone (DEX) on the expression of Tregs in allergic rhinitis (AR) mice, and explore the mechanism of glucocorticoid in the treatment of AR. METHOD: AR murine model was established by sensitization and challenge with OVA, besides intervention treatment with DEX was carried out in AR model. The behavior observation was used to evaluate the improvement effect of DEX on AR symptoms. The morphological characteristics of nasal tissues were observed by HE staining after fixation and decalcification...
June 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26334989/decreased-activation-induced-cell-death-by-ebv-transformed-b-cells-from-a-patient-with-autoimmune-lymphoproliferative-syndrome-caused-by-a-novel-faslg-mutation
#15
Raquel Ruiz-García, Sergio Mora, Gema Lozano-Sánchez, Luis Martínez-Lostao, Estela Paz-Artal, Jesús Ruiz-Contreras, Alberto Anel, Luis I González-Granado, David Moreno-Pérez, Luis M Allende
BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency characterized by chronic lymphoproliferation, autoimmune manifestations, expansion of double-negative T-cells, and susceptibility to malignancies. Most cases of ALPS are caused by germline or somatic FAS mutations. We report the case of an ALPS patient due to a novel homozygous Fasligand gene mutation (ALPS-FASLG). METHODS: ALPS biomarkers were measured and FASLG mutation was identified...
December 2015: Pediatric Research
https://www.readbyqxmd.com/read/26310940/blockade-of-cd40-ligand-for-intercellular-communication-reduces-hypertension-placental-oxidative-stress-and-at1-aa-in-response-to-adoptive-transfer-of-cd4-t-lymphocytes-from-rupp-rats
#16
Denise C Cornelius, Javier Castillo, Justin Porter, Lorena M Amaral, Nathan Campbell, Adrienne Paige, Alexia J Thomas, Ashlyn Harmon, Mark W Cunningham, Kedra Wallace, Florian Herse, Gerd Wallukat, Ralf Dechend, Babbette LaMarca
Preeclampsia (PE) is associated with altered immune activation during pregnancy. We have previously shown that adoptive transfer of CD4(+) T cells from the reduced uterine perfusion pressure (RUPP) rat model of PE increases blood pressure, oxidative stress (ROS), and inflammation in normal pregnant recipient rats. The objective of this study was to determine if blockade of communication via the CD40-CD40 ligand (CD40L) interaction between placental ischemia-induced CD4(+) T cells with endogenous normal pregnant (NP) cells would improve pathophysiology that was previously observed in NP recipient rats of RUPP CD4(+) T cells...
November 15, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26306147/the-immunosuppressive-activity-of-amniotic-membrane-mesenchymal-stem-cells-on-t-lymphocytes
#17
Fatemeh Alikarami, Fatemeh Yari, Naser Amirizadeh, Mahin Nikougoftar, Mohammad Ali Jalili
BACKGROUND: Mesenchymal Stem Cells (MSCs) are isolated from different sources like placenta. The placenta and its membranes like Amniotic Membrane (AM) are readily available and easy to work with. There is only limited knowledge on the immunomodulatory properties of human Amniotic Membrane-derived Mesenchymal Stem Cells (hAM-MSCs). The aim of this study was to survey the suppressive activity of hAM-MSCs on T lymphocytes in vitro. METHODS: Human AMs were obtained after caesarean section births from healthy women...
July 2015: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/26297915/immunomodulation-of-host-protective-immune-response-by-regulating-foxp3-expression-and-treg-function-in-leishmania-infected-balb-c-mice-critical-role-of-irf1
#18
Bidisha Paul Chowdhury, Shibali Das, Saikat Majumder, Kuntal Halder, Sweta Ghosh, Satabdi Biswas, Syamdas Bandyopadhyay, Subrata Majumdar
Visceral leishmaniasis (VL), caused by a protozoan parasite Leishmania donovani, is still a threat to mankind due to treatment failure, drug resistance and coinfection with HIV. The limitations of first-line drugs have led to the development of new strategies to combat this dreaded disease. Recently, we have shown the immunomodulatory property of Ara-LAM, a TLR2 ligand, against leishmanial pathogenesis. In this study, we have extended our study to the effect of Ara-LAM on regulatory T cells in a murine model of VL...
November 2015: Pathogens and Disease
https://www.readbyqxmd.com/read/26155930/evaluation-of-improvement-of-onychomycosis-in-hiv-infected-patients-after-initiation-of-combined-antiretroviral-therapy-without-antifungal-treatment
#19
Patricia Ruíz-López, Gabriela Moreno-Coutiño, Ramón Fernández-Martínez, Jessica Espinoza-Hernández, Patricia Rodríguez-Zulueta, Gustavo Reyes-Terán
Onychomycosis in HIV-infected patients has a prevalence of 20-44% and is more frequently seen with CD4(+) T cell counts ≤450 cel μl(-1). There are case reports of improvement in onychomycosis after initiation of combined antiretroviral therapy (cART), but there are no prospective studies that prove the existence and frequency of this phenomenon. The aim of this study was to evaluate if HIV-infected patients with onychomycosis who begin cART improve and/or cure without antifungal treatment. We included HIV-infected patients with onychomycosis who had not started cART and nor received antifungal therapy during 6 months prior to the study...
September 2015: Mycoses
https://www.readbyqxmd.com/read/26046326/neonatal-regulatory-t-cells-have-reduced-capacity-to-suppress-dendritic-cell-function
#20
Cesar M Rueda, Maria E Moreno-Fernandez, Courtney M Jackson, Suhas G Kallapur, Alan H Jobe, Claire A Chougnet
Regulatory T cells (Treg cells) limit contact between dendritic cells (DCs) and conventional T cells (Tcons), decreasing the formation of aggregates as well as down-modulating the expression of co-stimulatory molecules by DCs, thus decreasing DC immunogenicity and abrogating T-cell activation. Despite the importance of this Treg-cell function, the capacity of Treg cells from term and preterm neonates to suppress DCs, and the suppressive mechanisms they use, are still undefined. We found that, relative to adult Treg cells, activated Treg cells from human neonates expressed lower FOXP3 and CTLA-4, but contained higher levels of cAMP...
September 2015: European Journal of Immunology
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