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https://www.readbyqxmd.com/read/29765367/detection-of-bacteriophage-particles-containing-antibiotic-resistance-genes-in-the-sputum-of-cystic-fibrosis-patients
#1
Maryury Brown-Jaque, Lirain Rodriguez Oyarzun, Thais Cornejo-Sánchez, Maria T Martín-Gómez, Silvia Gartner, Javier de Gracia, Sandra Rovira, Antonio Alvarez, Joan Jofre, Juan J González-López, Maite Muniesa
Cystic fibrosis (CF) is a chronic disease in which the bacterial colonization of the lung is linked to an excessive inflammatory response that leads to respiratory failure. The microbiology of CF is complex. Staphylococcus aureus is the first bacterium to colonize the lungs in 30% of pediatric CF patients, and 80% of adult patients develop a chronic Pseudomonas aeruginosa infection, but other microorganisms can also be found. The use of antibiotics is essential to treat the disease, but antibiotic performance is compromised by resistance mechanisms...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29760961/ctx-m-15-is-established-in-most-multidrug-resistant-uropathogenic-enterobacteriaceae-and-pseudomonaceae-from-hospitals-in-nigeria
#2
David Olusoga Ogbolu, O A Terry Alli, Mark Alexander Webber, Adeolu Sunday Oluremi, Omoboriowo Moses Oloyede
β-Lactam antibiotics are widely used to treat urinary tract infections in Nigeria. This study aimed to determine the presence and characteristics of extended spectrum β-lactamases in commonly isolated uropathogenic Gram-negative bacteria (GNB) in Nigeria. Fifty non-duplicate GNB isolates consisting of Escherichia coli , 19; Klebsiella pneumoniae , 21; and Pseudomonas aeruginosa , 10 were obtained from three tertiary hospitals in Nigeria. The antibiotic susceptibility testing of all isolates to a panel of antibiotics including minimum inhibitory concentrations (MICs) and extended spectrum β-lactamases was determined...
April 2018: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29760134/oxa-72-mediated-carbapenem-resistance-in-sequence-type-1-multidrug-colistin-resistant-acinetobacter-baumannii-associated-with-urinary-tract-infection-in-a-dog-from-serbia
#3
Dusan Misic, Jelena Asanin, Joachim Spergser, Michael Szostak, Igor Loncaric
Multidrug resistant Acinetobacter (A.) baumannii is primarily important as a causative agent of difficult to treat nosocomial infections in humans (1).….
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29724185/clonal-diversity-and-genetic-profiling-of-antibiotic-resistance-among-multidrug-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-a-tertiary-care-hospital-in-saudi-arabia
#4
Taher Uz Zaman, Maha Alrodayyan, Maha Albladi, Mohammed Aldrees, Mohammed Ismail Siddique, Sameera Aljohani, Hanan H Balkhy
BACKGROUND: The nexus between resistance determinants, plasmid type, and clonality appears to play a crucial role in the dissemination and survival of carbapenem-resistant Klebsiella pneumoniae (CRKP). The incidence of infections involving CRKP in Saudi Arabia is increasing and there is a need for detailed molecular profiling of this pathogen for CRKP surveillance and control. METHODS: The resistance determinants of 71 non-redundant CRKP isolates were investigated by polymerase chain reaction (PCR) and sequencing...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29720352/bacteremia-and-meningitis-caused-by-oxa-23-producing-acinetobacter-baumannii-molecular-characterization-and-susceptibility-testing-for-alternative-antibiotics
#5
Kamile Francine Schuertz, Felipe Francisco Tuon, Jussara Kasuko Palmeiro, Danieli Conte, João Paulo Marochi Telles, Lucas Eduardo Trevisoli, Libera Maria Dalla-Costa
BACKGROUND: Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs. OBJECTIVE: Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism. METHODS: Twenty-six A. baumannii isolates from 23 patients were identified by MALDI-TOF and automated methods and genotyped using pulsed field genotyping electrophoresis...
April 24, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29694266/comparison-of-carba-np-direct-carbapenem-inactivation-method-and-%C3%AE-carba-tests-for-detection-of-carbapenemase-production-in-enterobacteriaceae
#6
Banu Bayraktar, Ayşe Barış, Gülşah Malkoçoğlu, Duygu Erdemir, Nur Kına
Rapid and accurate detection of carbapenemase-producing isolates are extremely important for management of antimicrobial therapy and the implementation of infection control measures. We evaluated the performance of Carba NP-direct, carbapenem inactivation method (CIM), and the commercial β-CARBA tests for detection of carbapenemase production in Enterobacteriaceae. Enterobacteriaceae isolates with previously characterized carbapenemase types (n = 110) and non-carbapenemase-producing Escherichia coli (n = 15) isolates were tested...
April 25, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29692589/occurrence-of-bla-genes-encoding-carbapenem-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-from-intensive-care-unit-in-a-tertiary-care-hospital
#7
Jayanthi Siva Subramaniyan, Jeya Meenakshi Sundaram
CONTEXT: ICU shows increasing incidence of infection associated with the use of invasive procedures for the diagnostic purpose as well as the indiscriminate use of antibiotics. Pseudomonas aeruginosa and Acinetobacter species are "very successful" pathogen and the emergence of the Metallo-β-Lactamases (MBL) is becoming a therapeutic challenge. AIMS: To isolate the Nonfermenting Gram negative bacilli from the ICU samples. To identify the metallo betalactamase producers and to detect the bla gene presence among the Pseudomonas aeruginosa and Acinetobacter baumannii ...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692474/molecular-detection-of-bla-ndm-1-new-delhi-metallobetalactamase-1-in-nosocomial-enterobacteriaceae-isolates-by-nested-multiplex-polymerase-chain-reaction
#8
Parnika Chandola, R M Gupta, Mahima Lall, Sourav Sen, S P S Shergill, Vibha Dutta
Background: Carbapenems are considered "drugs of last resort" in many life-threatening infections. Advent of carbapenemases like KPC, OXA-48, VIM, IMP, and NDM have greatly affected the efficacy of these drugs, posing serious threat to global health and infection control. NDM bears special significance to the India subcontinent, labeled as place of origin and reservoir. NDM tends to escape detection by routine phenotypic methods, requiring molecular confirmation. This study utilizes nested, multiplex polymerase chain reaction (PCR) for reliable detection of bla NDM-1 in nosocomial Enterobacteriaceae isolates...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29673319/carbapenemase-producing-enterobacteriaceae-in-mexico-report-of-seven-non-clonal-cases-in-a-pediatric-hospital
#9
Alejandra Aquino-Andrade, Jocelin Merida-Vieyra, Eduardo Arias de la Garza, Patricia Arzate-Barbosa, Agustín De Colsa Ranero
BACKGROUND: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016. RESULTS: The Enterobacteriaceae identified were three Escherichia coli strains (producing OXA-232, NDM-1 and KPC-2), two Klebsiella pneumoniae strains (producing KPC-2 and NDM-1), one Klebsiella oxytoca strain producing OXA-48 and one Enterobacter cloacae strain producing NDM-1...
April 19, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29671219/ceftazidime-avibactam-a-review-in-the-treatment-of-serious-gram-negative-bacterial-infections
#10
Matt Shirley
Ceftazidime-avibactam (Zavicefta® ) is an intravenously administered combination of the third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase inhibitor avibactam. In the EU, ceftazidime-avibactam is approved for the treatment of adults with complicated urinary tract infections (cUTIs) [including pyelonephritis], complicated intra-abdominal infections (cIAIs), hospital-acquired pneumonia (HAP) [including ventilator-associated pneumonia (VAP)], and other infections caused by aerobic Gram-negative organisms in patients with limited treatment options...
April 18, 2018: Drugs
https://www.readbyqxmd.com/read/29665444/ndm-1-and-oxa-23-producing-acinetobacter-baumannii-isolated-from-intensive-care-unit-patients-in-tunisia
#11
Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker
Gastrointestinal colonization by carbapenem-resistant Acinetobacter baumannii (CRAB), is a critical step before nosocomial infection. Our objective was to evaluate CRAB intestinal carriage in patients admitted in the intensive care unit (ICU) of a Tunisian Hospital and to determine the antimicrobial resistance mechanisms involved. From December-2014 to February-2015, all 63 patients admitted at the ICU were screened for rectal CRAB-colonization upon admission and once weekly thereafter. ICU-patients who acquired a CRAB-nosocomial-infection were also included...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29661874/characterization-of-extensively-or-pandrug-resistant-st147-and-st101-oxa-48-producing-klebsiella-pneumoniae-isolates-causing-bloodstream-infections-in-icu-patients
#12
Kalliope Avgoulea, Vincenzo Di Pilato, Olympia Zarkotou, Samanta Sennati, Leda Politi, Antonio Cannatelli, Katerina Themeli-Digalaki, Tommaso Giani, Athanassios Tsakris, Gian Maria Rossolini, Spyros Pournaras
Carbapenem-resistant Klebsiella pneumoniae cause important healthcare-associated infections worldwide. An outbreak of ST11 OXA-48-producing K. pneumoniae isolates (OXA-48-Kp) occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp recovered from 19 ICU patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. β-lactamase genes were detected by PCR. All isolates were typed by PFGE/MLST and 10 representative isolates by next generation sequencing (NGS)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29659861/in-vitro-activity-of-imipenem-relebactam-against-gram-negative-eskape-pathogens-isolated-in-17-european-countries-2015-smart-surveillance-programme
#13
James A Karlowsky, Sibylle H Lob, Krystyna M Kazmierczak, Stephen P Hawser, Sophie Magnet, Katherine Young, Mary R Motyl, Daniel F Sahm
Objectives: Relebactam is an inhibitor of class A β-lactamases, including KPC β-lactamases, and class C β-lactamases, and is currently under clinical development in combination with imipenem. The objective of the current study was to evaluate the in vitro activity of imipenem/relebactam against Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) submitted by clinical laboratories in 17 European countries to the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance programme in 2015...
April 11, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29659796/dissemination-of-multi-resistant-gram-negative-bacteria-into-german-wastewater-and-surface-waters
#14
Heike Müller, Esther Sib, Mike Gajdiss, Ursula Klanke, Franziska Lenz-Plet, Vanessa Barabasch, Cathrin Albert, Anna Schallenberg, Christian Timm, Nicole Zacharias, Ricarda Maria Schmithausen, Steffen Engelhart, Martin Exner, Marijo Parcina, Christiane Schreiber, Gabriele Bierbaum
Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with ESBL (extended spectrum beta-lactamase) producing Gram-negative bacteria, however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant into the receiving surface waters...
April 6, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#15
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29648629/antibiotic-pressure-on-the-acquisition-and-loss-of-antibiotic-resistance-genes-in-klebsiella-pneumoniae
#16
Patricia J Simner, Annukka A R Antar, Stephanie Hao, James Gurtowski, Pranita D Tamma, Clare Rock, Belita N A Opene, Tsigereda Tekle, Karen C Carroll, Michael C Schatz, Winston Timp
Objectives: In this study, we characterize a concurrent disseminated infection with a virulent hypermucoviscous (HMV) Klebsiella pneumoniae and an OXA-181-producing XDR K. pneumoniae from a patient with recent hospitalization in India. During exposure to meropenem therapy, the highly susceptible HMV K. pneumoniae became resistant to carbapenems, consistent with the acquisition of blaOXA-181. Methods: Twelve K. pneumoniae isolates were recovered from the patient and the hospital room environment over a 3 month hospitalization...
April 10, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29627985/strategic-approaches-to-overcome-resistance-against-gram-negative-pathogens-using-%C3%AE-lactamase-inhibitors-and-%C3%AE-lactam-enhancers-activity-of-three-novel-diazabicyclooctanes-wck-5153-zidebactam-wck-5107-and-wck-4234
#17
Krisztina M Papp-Wallace, Nhu Q Nguyen, Michael R Jacobs, Christopher R Bethel, Melissa D Barnes, Vijay Kumar, Saralee Bajaksouzian, Susan D Rudin, Philip N Rather, Satish Bhavsar, Tadiparthi Ravikumar, Prasad K Deshpande, Vijay Patil, Ravindra Yeole, Sachin S Bhagwat, Mahesh V Patel, Focco van den Akker, Robert A Bonomo
Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of paramount importance. Here, three novel diazabicyclooctanes (DBOs), WCK 5153, zidebactam (WCK 5107), and WCK 4234 (compounds 1-3, respectively), were synthesized and biochemically characterized against clinically important bacteria. Compound 3 inhibited class A, C, and D β-lactamases with unprecedented k2 / K values against OXA carbapenemases...
April 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29563908/occurrence-of-bla-ndm-variants-among-enterobacteriaceae-from-a-neonatal-intensive-care-unit-in-a-northern-india-hospital
#18
Nayeem Ahmad, Shamsi Khalid, Syed M Ali, Asad U Khan
Carbapenem-resistance among enterobacteriaceae has become a global health concern. The objective of this study was to understand NDM producing enterobacteriaceae and their genetic basis of resistance, spreading in neonatal intensive care unit. Carbapenem resistant NDM producing enterobacteriaceae isolates were recovered from rectal swab and blood sample of infants admitted in NICU. These were determined by using Carba-NP test. All isolates were identified using BD PhoenixTM-100 and MICs were determined by broth microdilution method...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29558475/molecular-epidemiology-and-drug-resistant-mechanism-in-carbapenem-resistant-klebsiella-pneumoniae-isolated-from-pediatric-patients-in-shanghai-china
#19
Xingyu Zhang, Di Chen, Guifeng Xu, Weichun Huang, Xing Wang
Infection by carbapenem-resistant Klebsiella pneumoniae (CR-KP) is a public health challenge worldwide, in particular among children, which was associated with high morbidity and mortality rates. There was limited data in pediatric populations, thus this study aimed to investigate molecular epidemiology and drug resistant mechanism of CR-KP strains from pediatric patients in Shanghai, China. A total of 41 clinical CR-KP isolates from sputum, urine, blood or drainage fluid were collected between July 2014 and May 2015 in Shanghai Children's Medical Center...
2018: PloS One
https://www.readbyqxmd.com/read/29530861/discovery-of-a-novel-metallo-%C3%AE-lactamase-inhibitor-that-potentiates-meropenem-activity-against-carbapenem-resistant-enterobacteriaceae
#20
Martin Everett, Nicolas Sprynski, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Juliette Bougnon, Clarisse Lozano, David T Davies, Simon Leiris, Magdalena Zalacain, Ian Morrissey, Sophie Magnet, Kirsty Holden, Peter Warn, Filomena De Luca, Jean-Denis Docquier, Marc Lemonnier
Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are increasingly prevalent and have become a major worldwide threat to human health. Carbapenem resistance is driven primarily by the acquisition of β-lactamase enzymes, which are able to degrade carbapenem antibiotics (hence termed carbapenemases) and result in high levels of resistance and treatment failure. Clinically relevant carbapenemases include both serine β-lactamases (SBLs; e.g., KPC-2 and OXA-48) and metallo-β-lactamases (MBLs), such as NDM-1...
May 2018: Antimicrobial Agents and Chemotherapy
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