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Insulinoma

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https://www.readbyqxmd.com/read/29753794/insulinoma-masquerading-as-transient-neurocognitive-impairment-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#1
Daniel Varela, Amy Yu, David Saxon
No abstract text is available yet for this article.
May 10, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29744084/frequent-falls-and-confusion-recurrent-hypoglycemia-in-a-patient-with-tuberous-sclerosis-complex
#2
Alexander N Comninos, Lisa Yang, Ali Abbara, Waljit S Dhillo, J H Duncan Bassett, Jeannie F Todd
Recurrent hypoglycemia is common, but its presentation is often insidious resulting in delays in diagnosis and significant morbidity. We describe a case of an insulinoma presenting with falls and confusion in a patient with tuberous sclerosis, demonstrating the importance of early hypoglycemia identification and a potential shared molecular pathogenesis.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29727904/endoscopic-ultrasound-guided-radiofrequency-ablation-for-management-of-benign-solid-pancreatic-tumors
#3
Jun-Ho Choi, Dong-Wan Seo, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim
BACKGROUND:  Radiofrequency ablation (RFA) has been increasingly employed in experimental and clinical settings for the management of pancreatic lesions. This study aimed to assess the safety and efficacy of endoscopic ultrasound (EUS)-guided RFA for benign solid pancreatic tumors. METHODS:  In a single-center, prospective study, 10 patients with benign solid pancreatic tumors underwent EUS-RFA. After the RFA electrode had been inserted into the pancreatic mass, the radiofrequency generator was activated to deliver 50 W of ablation power...
May 4, 2018: Endoscopy
https://www.readbyqxmd.com/read/29717701/-severe-hypoglycaemia-due-to-insulinoma-after-gastric-bypass-surgery
#4
Anne Sjøbjerg, Per Løgstrup Poulsen, Stine Kramer, Bjørn Richelsen
Postprandial hypoglycaemia with endogenous hyper-insulinaemia is relatively common after gastric bypass (GB) surgery. However, alternative aetiologies of hypoglycaemia should be kept in mind. We report a case of severe hypo-glycaemia in a patient who had previously undergone GB surgery for morbid obesity. Hypoglycaemic episodes differed from typical GB-related hypoglycaemia by occurring during fasting periods. Examination revealed insulinoma, and nine months after resection the patient remained symptom free...
April 23, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29710530/resveratrol-improves-uric-acid-induced-pancreatic-%C3%AE-cells-injury-and-dysfunction-through-regulation-of-mir-126
#5
Ying Xin, Haiyan Zhang, Zhaotong Jia, Xiaoqian Ding, Yong Sun, Qiang Wang, Tao Xu
Resveratrol (RSV) has been reported to exert anti-inflammatory, anti-oxidant and anti-cancer effects both in vivo and in vitro, and is widely used to treat various diseases. However, the effect of RSV on type 2 diabetes (T2D) is still unclear. The present study aimed to explore the effect of RSV on UA-induced cell injury and dysfunction in pancreatic β-cells. The mouse insulinoma cell line Min6 was treated with 5 mg/dl UA and different concentrations of RSV. Then, cell viability, apoptosis, apoptosis-associated factors, iNOS expression and insulin secretion were examined by CCK-8, flow cytometry, western blot, qRT-PCR and glucose-stimulated insulin secretion (GSIS), respectively...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29697692/-physical-minimally-invasive-treatment-of-pancreatic-insulinoma
#6
R S Dugarova, S V Berelavichus, A R Kaldarov, D S Gorin
No abstract text is available yet for this article.
2018: Khirurgiia
https://www.readbyqxmd.com/read/29696624/therapeutic-targeting-of-tumor-associated-macrophages-in-pancreatic-neuroendocrine-tumors
#7
Sebastian Krug, Rami Abbassi, Heidi Griesmann, Bence Sipos, Dominik Wiese, Peter Rexin, Annika Blank, Aurel Perren, Johannes Haybaeck, Stefan Hüttelmaier, Anja Rinke, Thomas M Gress, Patrick Michl
Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neuroendocrine neoplasms with varying biological behaviour and response to treatment. Although targeted therapies have been shown to improve the survival for patients at advanced stage, resistance to current therapies frequently occurs during the course of therapy. Previous reports indicate that the infiltration of tumor-associated macrophages (TAMs) in PNETs might correlate with tumor progression and metastasis formation. We aimed to evaluate the prognostic and functional impact of TAMs in human PNETs in vitro and in vivo and to investigate the effect of therapeutic targeting TAMs in a genetic PNET mouse model...
April 26, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29691623/minimally-invasive-versus-open-treatment-for-benign-sporadic-insulinoma-comparison-of-short-term-and-long-term-outcomes
#8
Giulio Belfiori, Dominik Wiese, Stefano Partelli, Sabine Wächter, Elisabeth Maurer, Stefano Crippa, Massimo Falconi, Detlef K Bartsch
BACKGROUND: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas, and its incidence is estimated at 0.4%. The treatment of choice is organ-preserving resection. The aim of this study was to compare short-term and long-term outcomes of minimally invasive laparoscopic or robotic enucleation (MIC-EN) and open enucleation (O-EN) for sporadic benign insulinoma. METHODS: A retrospective bi-institutional analysis of 71 patients who underwent an enucleation for sporadic benign insulinoma between 2003 and 2016 was performed...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29678908/the-lim-homeodomain-protein-isl1-mediates-the-function-of-tcf7l2-in-pancreatic-beta-cells
#9
Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, Cristina M Nostro, Tianru Jin
Pancreatic β-cell Tcf7l2 deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis, and β-cell gene expression. As the LIM homeodomain protein Isl1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of Tcf7l2. We aimed to determine the role of Isl1 in mediating the function of Tcf7l2 and the incretin hormone GLP-1 in pancreatic β-cells. Effect of dominant negative TCF7L2 (TCF7L2DN) mediated Wnt pathway functional knockdown on Isl1 expression was determined in βTCFDN mouse islets and in the rat insulinoma cell line INS-1 832/13...
April 20, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29662644/autoantibodies-against-islet-cell-antigens-in-children-with-type-1-diabetes-mellitus
#10
Bi-Wen Cheng, Fu-Sung Lo, An-Mei Wang, Chen-Mei Hung, Chi-Yu Huang, Wei-Hsin Ting, Mei-Ore Yang, Chao-Hsu Lin, Chia-Ching Chen, Chiung-Ling Lin, Yi-Lei Wu, Yann-Jinn Lee
We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by χ 2 test, binary logistic regression, and Spearman rank correlation. Of the 750 T1D patients, 66.3% had GADA, 65.3% IA2A, 35.7% IAA, and 17.2% no autoantibodies. The prevalence of GADA and IA2A significantly decreased along T1D duration...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662318/rare-malignant-insulinoma-with-multiple-liver-metastases-derived-from-ectopic-pancreas-3-year-follow-up-and-literature-review
#11
Qing Liu, Jianghui Duan, Yumin Zheng, Jie Luo, Xiaopin Cai, Huangying Tan
Here, we report the diagnosis and treatment of a very rare case of malignant insulinoma derived from ectopic pancreas. A middle-aged woman presented with a 6-year history of recurrent hypoglycemia with multiple lesions in liver. Admission workup revealed elevated serum insulin and C-peptide, as well as multiple lesions in the liver (largest being 4.3 cm), enlarged lymph nodes around the pancreas, and a lesion (of 3.5 cm) at the proximal jejunum, as shown by contrast computed tomography (CT). Liver biopsy showed the lesions to be well-differentiated neuroendocrine tumors, grade G1...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29658671/-a-case-of-insulinoma-complicated-with-secondary-adrenal-insufficiency
#12
Yao Li, Hui Chen
A middle-aged male patient with recurrent hypoglycemia was diagnosed as insulinoma according to the symptoms and the laboratory tests. Laboratory tests also showed low cortisol and adrenocortico-tropic hormone (ACTH) levels, therefore adrenal insufficiency was diagnosed and hydrocortisone was given. The hormone replacement therapy was terminated after surgery, and ACTH and cortisol levels returned to normal.
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29629318/role-of-surgery-in-pancreatic-neuroendocrine-tumor
#13
REVIEW
Kai Pun Wong, Julian Shun Tsang, Brian Hung-Hin Lang
Pancreatic neuroendocrine tumours (PNETs) are rare. They are generally accepted to be slow-growing and have an indolent course. These tumours can be non-functioning or functioning, consisting of a biochemically heterogeneous group of tumours including insulinomas, gastrinomas, carcinoids and glucagonomas. Although surgery remains the mainstay of treatment, controversy still exists especially for non-functioning tumours <2 cm in size. Whether these should be resected or undergo intensive surveillance remains unclear...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629316/management-of-functional-neuroendocrine-tumors-of-the-pancreas
#14
REVIEW
Kjell Öberg
Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Recent whole genome sequencing of pNETs has demonstrated mutations in the DNA repair genes MUTYH and point mutations and gene fusions in four main pathways from chromatin remodeling, DNA damage repair, activation of mechanistic target of rapamycin (mTOR) signaling and the telomere maintenance...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29627323/apoptosis-signal-regulating-kinase-1-and-nadph-oxidase-mediate-human-amylin-evoked-redox-stress-and-apoptosis-in-pancreatic-beta-cells
#15
Sanghamitra Singh, Diti Chatterjee Bhowmick, Satyabrata Pany, Myungkuk Joe, Noor Zaghlula, Aleksandar M Jeremic
Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p38 MAPK and c-Jun N-terminal (JNK) kinase. However, the molecular link and causality between hA-evoked redox stress, NOX activity and MAP kinases signaling in pancreatic β-cells is incompletely understood...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29594255/enhanced-expression-of-the-key-mitosis-regulator-cyclin-b1-is-mediated-by-pdz-binding-kinase-in-islets-of-pregnant-mice
#16
Tadayoshi Uesato, Takeshi Ogihara, Akemi Hara, Hitoshi Iida, Takeshi Miyatsuka, Yoshio Fujitani, Satoru Takeda, Hirotaka Watada
The proliferation of pancreatic β cells is enhanced to enable an increase in β -cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant and nonpregnant mice by gene expression profiling and found that the expression of postsynaptic density-95/Discs large/zonula occludens-1 (PDZ)-binding kinase (Pbk), a member of the mitogen-activated protein kinase kinase family, is increased in pregnant mouse islets compared with control mouse islets...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29589453/-multidisciplinary-approach-to-surgical-disorders-of-the-pancreas-in-children
#17
J Šnajdauf, M Rygl, O Petrů, B Frýbová, J Náhlovský, V Mixa, R Keil, J Bronský, M Kynčl, R Kodet
INTRODUCTION: Surgical diseases of the pancreas in children are not common and may be associated with significant morbidity and potential mortality. A multidisciplinary approach is essential for correct diagnosis, surgical strategy and postoperative as well as follow-up care. METHOD: Retrospective analysis of patients operated on due to a pathological lesion of the pancreas focused on diagnostics, operating procedures, postoperative complications, and long-term results...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29589392/pioglitazone-attenuates-palmitate-induced-inflammation-and-endoplasmic-reticulum-stress-in-pancreatic-%C3%AE-cells
#18
Seok Woo Hong, Jinmi Lee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Eun Jung Rhee, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won Young Lee
BACKGROUND: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear. METHODS: To identify the potential functions of PPARγ in β-cells, we treated mouse insulinoma 6 (MIN6) cells with the PPARγ agonist pioglitazone in conditions of lipotoxicity, endoplasmic reticulum (ER) stress, and inflammation. RESULTS: Palmitate-treated cells incubated with pioglitazone exhibited significant improvements in glucose-stimulated insulin secretion and the repression of apoptosis, as shown by decreased caspase-3 cleavage and poly (adenosine diphosphate [ADP]-ribose) polymerase activity...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29588555/insulin-autoimmune-syndrome-a-rare-case-of-hypoglycaemia-resolving-with-immunosuppression
#19
A Hunter, U Graham, J R Lindsay
We report a case of a 58-year-old male presenting with confusion and hypoglycaemia. There had been no prior exposure to oral hypoglycaemic agents or insulin. He was found to have inappropriate endogenous hyperinsulinaemia. Insulinoma was excluded by detailed endocrine assessment. Insulin antibodies were positive in keeping with a diagnosis of insulin autoimmune syndrome (IAS). He was treated with prednisolone 5mg once daily and nutritional supplements leading to resolution of acute confusion and hypoglycaemic episodes...
January 2018: Ulster Medical Journal
https://www.readbyqxmd.com/read/29574508/scopoletin-intervention-in-pancreatic-endoplasmic-reticulum-stress-induced-by-lipotoxicity
#20
Kalaivanan Kalpana, Emayavaramban Priyadarshini, S Sreeja, Kalivarathan Jagan, Carani Venkatraman Anuradha
Endoplasmic reticulum (ER), a dynamic organelle, plays an essential role in organizing the signaling pathways involved in cellular adaptation, resilience, and survival. Impairment in the functions of ER occurs in a variety of nutritive disorders including obesity and type 2 diabetes. Here, we hypothesize that (scopoletin) SPL, a coumarin, has the potential to alleviate ER stress induced in vitro and in vivo models by lipotoxicity. To test this hypothesis, the ability of SPL to restore the levels of proteins of ER stress was analyzed...
March 25, 2018: Cell Stress & Chaperones
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