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https://www.readbyqxmd.com/read/29766652/mucosal-microflora-in-head-and-neck-cancer-patients
#1
A Almståhl, C Finizia, A Carlén, B Fagerberg-Mohlin, T Alstad
OBJECTIVE: To analyse the tongue and buccal microflora prospectively in head and neck cancer patients treated with radiation therapy (RT). METHODS: In 33 dentate patients, microbial samples from the tongue and buccal mucosa were collected pretreatment, during treatment, and 6 months, 1 year and 2 years post-treatment. Microorganisms associated with oral health and oral disorders were analysed using cultivation technique. Oral mucositis was scored at the appointment during treatment...
May 15, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29718150/photothermal-treatment-with-egfrmab-aunps-induces-apoptosis-in-hypopharyngeal-carcinoma-cells-via-pi3k-akt-mtor-and-dna-damage-response-pathways
#2
Yingying Zhang, Linhai Cong, Jiayan He, Yu Wang, Yingying Zou, Zhihong Yang, Yuexin Hu, Shiwen Zhang, Xiaoguang He
Hypopharyngeal carcinoma (HC) is one of the most malignant tumors in the upper aerodigestive tract. Currently, there are no effective treatments for HC. Gold nanoparticles (AuNPs) are a promising tool that can be used for plasmonic photothermal therapy (PPTT), which refers to the use of electromagnetic radiation, most often in near infrared (NIR) region, for the treatment of various medical conditions including cancer. AuNPs have been proved to be a promising tool for NIR spectroscopy-mediated photothermal therapies...
April 27, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29685526/paediatric-magnetic-resonance-enterography-in-inflammatory-bowel-disease
#3
Mary-Louise C Greer
Paediatric magnetic resonance enterography (MRE) has been increasingly employed in the evaluation of inflammatory bowel disease (IBD) in the past decade. This is in parallel with a global rise in paediatric-onset IBD, greater recognition of the hazards of ionizing radiation, especially in children, and improved treatment options. MRE is now the reference standard for assessing the small bowel in suspected or proven paediatric IBD, and is central to the diagnosis of Crohn's disease (CD), helping distinguish it from ulcerative colitis...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29681770/compliance-with-bladder-protocol-during-concurrent-chemoradiation-for-cancer-of-the-cervix-and-its-impact-on-enteritis-a-prospective-observational-study
#4
Sweta Bandanatham, Janaki Manur Gururajachar, Mohan Kumar Somashekar
Aim: This prospective study aims to assess the compliance with bladder protocol and the correlation with enteritis during pelvic radiation. Background: Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume especially in the last two weeks due to radiation enteritis and cystitis. Materials and methods: Histologically proven 35 cervical cancer patients treated with concurrent chemoradiation in a tertiary care center were the subjects of this prospective study...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29667769/targeting-the-phosphatidylinositol-3-kinase-akt-mechanistic-target-of-rapamycin-signaling-pathway-in-b-lineage-acute-lymphoblastic-leukemia-an-update
#5
REVIEW
Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri
Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15-20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo- and radiation therapy, including secondary malignancies, are a growing problem for leukemia survivors. Targeted therapy holds promising perspectives for cancer treatment as it may be more effective and have fewer side effects than conventional therapies. The phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway is a key regulatory cascade which controls proliferation, survival and drug-resistance of cancer cells, and it is frequently upregulated in the different subtypes of B-ALL, where it plays important roles in the pathophysiology, maintenance and progression of the disease...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29594911/analyzing-the-impact-of-compliance-with-national-guidelines-for-pancreatic-cancer-care-using-the-national-cancer-database
#6
Kathryn Jaap, Marcus Fluck, Marie Hunsinger, Jeffrey Wild, Tania Arora, Mohsen Shabahang, Joseph Blansfield
IMPORTANCE: Management of pancreatic cancer is complex, requiring coordination of multiple providers. National Comprehensive Cancer Network guidelines, developed for standardization and quality improvement, recommend a multimodal approach. OBJECTIVE: This study analyzed national rates of compliance with National Comprehensive Cancer Network recommendations, assessed factors affecting compliance, and evaluated whether compliance with evidence-based guidelines improved overall survival...
March 28, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29566662/age-greater-than-60-years-portends-a-worse-prognosis-in-patients-with-papillary-thyroid-cancer-should-there-be-three-age-categories-for-staging
#7
Rondi M Kauffmann, J Blair Hamner, Philip H G Ituarte, John H Yim
BACKGROUND: Age is an important prognostic factor in papillary thyroid cancer (PTC), with better survival observed in patients < 45 years of age, regardless of stage. Although the impact of increasing age on PTC-related survival is well-known, previous studies have focused on survival relative to age 45 years only. As the number of patients entering their 7th decade of life increases, PTC-related survival in this demographic becomes increasingly important. Survival in patients ≥ 60 years specifically compared to other groups has not previously been examined...
March 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29516956/use-of-simultaneous-radiation-boost-achieves-high-treatment-response-rate-in-patients-with-metastatic-gastric-cancer
#8
Ju Yang, Juan Liu, Shanbao Gao, Yang Yang, Weiwei Kong, Wei Ren, Lijing Zhu, Mi Yang, Jia Wei, Zhengyun Zou, Xiaoping Qian, Baorui Liu, Jing Yan
Objective: Intensity-modulated radiation therapy (IMRT) with a simultaneous integrated boost (SIB) could improve local control rates at different anatomic sites. However, little is known for its use in metastatic gastric cancer. Our study aimed to compare the treatment response rates of IMRI-SIB and conformal radiotherapy (CRT) in patients with metastatic gastric cancer. Materials and Methods: We retrospectively identified twenty patients with metastatic gastric cancer from 2013 to 2015, 12 given IMRT-SIB, and eight given CRT...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29482755/emerging-molecular-imaging-techniques-in-gynecologic-oncology
#9
REVIEW
Gigin Lin, Chyong-Huey Lai, Tzu-Chen Yen
Molecular imaging (mainly PET and MR imaging) has played important roles in gynecologic oncology. Emerging MR-based technologies, including DWI, CEST, DCE-MR imaging, MRS, and DNP, as well as FDG-PET and many novel PET radiotracers, will continuously improve practices. In combination with radiomics analysis, a new era of decision making in personalized medicine and precisely guided radiation treatment planning or real-time surgical interventions is being entered into, which will directly impact on patient survival...
April 2018: PET Clinics
https://www.readbyqxmd.com/read/29482146/tertiary-treatment-and-dual-disinfection-to-improve-microbial-quality-of-reclaimed-water-for-potable-and-non-potable-reuse-a-case-study-of-facilities-in-north-carolina
#10
Emily S Bailey, Lisa M Casanova, Otto D Simmons, Mark D Sobsey
Treated wastewater is increasingly of interest for either nonpotable purposes, such as agriculture and industrial use, or as source water for drinking water supplies; however, this type of advanced treatment for water supply is not always possible for many low resource settings. As an alternative, multiple barriers of physical, chemical and biological treatment with lower cost and simpler operation and maintenance have been proposed as more globally applicable. One such water reclamation system for both non-potable and potable reuse, is that approved by the State of North Carolina "for Type 2" reclaimed water (NCT2RW)...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29468678/image-guidance-doses-delivered-during-radiotherapy-quantification-management-and-reduction-report-of-the-aapm-therapy-physics-committee-task-group-180
#11
George X Ding, Parham Alaei, Bruce Curran, Ryan Flynn, Michael Gossman, T Rock Mackie, Moyed Miften, Richard Morin, X George Xu, Timothy C Zhu
BACKGROUND: With radiotherapy having entered the era of image guidance, or image-guided radiation therapy (IGRT), imaging procedures are routinely performed for patient positioning and target localization. The imaging dose delivered may result in excessive dose to sensitive organs and potentially increase the chance of secondary cancers and, therefore, needs to be managed. AIMS: This task group was charged with: a) providing an overview on imaging dose, including megavoltage electronic portal imaging (MV EPI), kilovoltage digital radiography (kV DR), Tomotherapy MV-CT, megavoltage cone-beam CT (MV-CBCT) and kilovoltage cone-beam CT (kV-CBCT), and b) providing general guidelines for commissioning dose calculation methods and managing imaging dose to patients...
February 22, 2018: Medical Physics
https://www.readbyqxmd.com/read/29452875/use-of-expanders-for-bowel-protection-in-pediatric-pelvic-tumor-radiation-therapy-15-years-of-tolerance-results
#12
Fernand Missohou
PURPOSE: Bowel is often the dose-limiting organ in curative pelvic irradiation because of radiation enteritis when dose exceeds 40 to 45 Gy. To limit radiation enteritis, a silicone tissue-expander prothesis (STEP) connected to a subcutaneous self-sealing valve was prospectively used in children undergoing pelvic or abdominal radiation therapy. This study reports the 15-year long-term outcomes of this prospective series. METHODS AND MATERIALS: Between 1987 and 2008, 29 children from 3 Paris institutions received pelvic radiation therapy after surgical placement of a STEP in the pelvis...
December 14, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29416174/considerations-for-the-long-term-treatment-of-pediatric-sarcoma-survivors
#13
Kurt R Weiss, Melissa N Zimel
Sarcomas are primary malignancies of the connective tissues. They are exceedingly rare in adults, but much more common in children. The historically recent advent of cytotoxic chemotherapy for pediatric sarcomas has revolutionized the treatment of these diseases and dramatically improved their prognoses. There is thus a population of pediatric sarcoma survivors that are "coming of age" as adults. However, this progress is not without consequences. Due to aggressive treatment protocols that include various combinations of surgery, chemotherapy, and radiation therapy, pediatric sarcoma survivors are at risk of myriad physical, medical, and psychological difficulties as they enter adulthood...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29396283/urological-survivorship-issues-among-adolescent-boys-and-young-men-who-are-cancer-survivors
#14
REVIEW
Troy Sukhu, Sherry Ross, R Matthew Coward
BACKGROUND: Urological survivorship issues encompass an area that may potentially be overlooked after treatment of childhood cancer in adolescent boys and young men. Side effects of cancer therapy may include subsequent development of erectile dysfunction (ED), hypogonadism, and infertility in adulthood. AIM: The purpose of this review is to focus on the etiology and prevalence of the range of sexual and gonadal dysfunction in adolescent boys and young men who are cancer survivors, while discussing current recommendations for evaluation and treatment...
January 27, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29386061/dihydroisotanshinone-i-combined-with-radiation-inhibits-the-migration-ability-of-prostate-cancer-cells-through-dna-damage-and-ccl2-pathway
#15
I-Yun Lee, Yin-Yin Lin, Yao-Hsu Yang, Yu-Shin Lin, Chun-Liang Lin, Wei-Yu Lin, Yu-Ching Cheng, Li-Hsin Shu, Ching-Yuan Wu
BACKGROUND: Radiotherapy plays an important role in the treatment of prostate cancer. Despite that sophisticated techniques of radiotherapy and radiation combined with chemotherapy were applied to the patients, some tumors may recur. Therefore, the study investigated the effect of dihydroisotanshinone I (DT) and the combination treatment of 5 μM DT and 5Gy irradiation (IR) against the migration ability of prostate cancer cells. METHODS: DT and the combination treatment were studied for its biological activity against migration ability of prostate cancer cells with transwell migration assay...
January 31, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29378625/outcome-and-prognostic-factors-in-cervical-cancer-patients-treated-with-surgery-and-concurrent-chemoradiotherapy-a-retrospective-study
#16
Yan-Mei Liu, Ling-Qin Ni, Sai-Sai Wang, Qian-Ling Lv, Wei-Jun Chen, Shen-Peng Ying
BACKGROUND: The objective of this study is to analyze the treatment outcome and secondary reactions in 98 patients with stage I-III cervical carcinoma who underwent postoperative radiotherapy. METHODS: From 2006 to 2014, 98 patients with stage I-III cervical carcinoma were treated with postoperative radiotherapy. The major histological type, found in 92.86% of the patients (91 cases), was squamous cell carcinoma. Patients were staged according to the 2002 TNM guidelines...
January 29, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29366941/inorganic-nanoparticles-a-potential-cancer-therapy-for-human-welfare
#17
REVIEW
Arivalagan Pugazhendhi, Thomas Nesakumar Jebakumar Immanuel Edison, Indira Karuppusamy, Brindhadevi Kathirvel
Cancer is an abnormal condition leading to uncontrolled cell division which causes damage to the body tissues. Around 100 types of cancer are studied so far namely breast cancer, lung cancer, skin cancer, prostate cancer, colon cancer and lymphoma. Major cancer therapies include chemotherapy, surgery and radiations but their major drawbacks are non-specifically distributed antitumor agents, uneven delivery of drug concentration to the tumour and low monitoring. Nanoparticles (NPs) are the newly trending field of nanomedicine implied in cancer therapy...
March 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29355803/full-endoscopic-interlaminar-approach-for-nerve-root-decompression-of-sacral-metastatic-tumor
#18
Sheng-Hua Tsai, Hsuan-Han Wu, Chun-Yuan Cheng, Chien-Min Chen
BACKGROUND: Endoscopic surgery has been successfully applied in treatment of degenerative spinal disease, but few studies have assessed its use in treating sacral metastasis. We report a successful full endoscopic interlaminar approach for sacral nerve root decompression of a sacral metastatic tumor. CASE DESCRIPTION: An 80-year-old man with a history of hepatocellular carcinoma presented with buttock pain with radiation to the right lower leg for 1 week. There was also decreased muscle power of the right lower extremity...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29354876/evaluating-treatment-patterns-for-small-cell-carcinoma-of-the-colon-using-the-national-cancer-database-ncdb
#19
Sadhana Balasubramanyam, Barrett P O'Donnell, Benjamin L Musher, Pavan M Jhaveri, Michelle S Ludwig
OBJECTIVE(S): The objective of this study was to characterize the clinicopathological prognostic factors and treatment patterns for small cell carcinoma (SCC) of the colon, a rare disease without standard treatment guidelines. METHODS: We analyzed clinicopathological and treatment variables for 503 cases of histologically proven SCC colon entered into the National Cancer Database (NCDB) between 2004 and 2013. Survival curves were generated using Kaplan-Meier and compared by the log-rank test...
January 22, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29338016/ultrasound-mediated-delivery-and-distribution-of-polymeric-nanoparticles-in-the-normal-brain-parenchyma-of-a-metastatic-brain-tumour-model
#20
Habib Baghirov, Sofie Snipstad, Einar Sulheim, Sigrid Berg, Rune Hansen, Frits Thorsen, Yrr Mørch, Catharina de Lange Davies, Andreas K O Åslund
The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug injection might induce toxicity, but encapsulation into nanoparticles reduces accumulation in normal tissue. Here we used a novel platform based on poly(2-ethyl-butyl cyanoacrylate) nanoparticle-stabilized microbubbles to permeabilize the BBB in a melanoma brain metastasis model. With a dual-frequency ultrasound transducer generating FUS at 1...
2018: PloS One
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