keyword
https://read.qxmd.com/read/37746882/risk-of-cardiovascular-disease-in-cancer-survivors-a-cohort-study-of-446-384-new-zealand-primary-care-patients
#21
JOURNAL ARTICLE
Essa Tawfiq, Romana Pylypchuk, J Mark Elwood, Mark McKeage, Sue Wells, Vanessa Selak
BACKGROUND: Given advances in the management of cancer, it is increasingly important for clinicians to appropriately manage the risk of cardiovascular disease (CVD) among cancer survivors. It is unclear whether CVD risk is increased among cancer survivors overall, and there is inconsistency in evidence to date about CVD incidence and mortality by cancer type. METHODS: Patients aged 30-74 years entered an open cohort study at the time of first CVD risk assessment, between 2004 and 2018, in primary care in New Zealand...
September 25, 2023: Cancer Medicine
https://read.qxmd.com/read/37729618/neurocognitive-impairment-associated-with-chronic-morbidity-in-long-term-survivors-of-hodgkin-lymphoma
#22
JOURNAL ARTICLE
Nicholas Steve Phillips, Daniel A Mulrooney, AnnaLynn M Williams, Wei Liu, Raja B Khan, Matthew Ehrhardt, Tim Folse, Matthew J Krasin, Deo Kumar S Srivastava, Kirsten K Ness, Melissa M Hudson, Noah D Sabin, Kevin R Krull
Thoracic radiation is associated with significant cardiopulmonary morbidities in long-term Hodgkin lymphoma (HL) survivors and may impact neurocognitive outcomes. Survivors (N=204, 52.5% female, mean[SD] age 36.6[8.01] years), treated with thoracic radiation, and age-, sex- and race/ethnicity-matched community controls (N=205, 51.7% female, age 36.7[9.17] years) completed standardized neurocognitive testing, echocardiography, pulmonary function tests, and vascular studies during the same visit. Treatments were abstracted from medical records...
September 20, 2023: Blood Advances
https://read.qxmd.com/read/37623337/plaque-rupture-in-a-hodgkin-lymphoma-survivor-without-cardiovascular-risk-factors-20-years-after-thoracic-radiotherapy-a-case-report
#23
Elissa A S Polomski, Michiel A de Graaf, J Wouter Jukema, M Louisa Antoni
BACKGROUND: Major improvements in cancer therapies have significantly contributed to increased survival rates of Hodgkin lymphoma (HL) survivors, outweighing cardiovascular side effects and the risks of radiation-induced heart disease. Non-invasive screening for coronary artery disease (CAD) starting five years after irradiation is recommended, as plaque development and morphology may differ in this high-risk population. Due to rapid plaque progression and a possibly higher incidence of non-calcified plaques, coronary artery calcium scoring may not be sufficient as a screening modality in HL survivors treated with thoracic radiotherapy...
July 31, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37581464/therapy-related-acute-myeloid-leukemia-in-non-hodgkin-lymphoma-survivors-risk-survival-outcomes-and-prognostic-factor-analysis
#24
JOURNAL ARTICLE
Utsav Joshi, Adheesh Bhattarai, Suman Gaire, Pravash Budhathoki, Vishakha Agrawal, Roshan Subedi, Bishesh S Poudyal, Prajwal Dhakal, Ronald Sham, Vijaya R Bhatt
BACKGROUND: Therapy-related acute myeloid leukemia (tAML) is a serious complication in patients with Non-Hodgkin lymphoma (NHL) exposed to chemotherapy or radiation. This extensive database study aims to quantify the risk of tAML in NHL and determine the impact of tAML on the overall survival (OS) of patients with NHL. MATERIALS AND METHODS: Patients diagnosed with NHL and de novo AML from 2009 to 2018 were identified from the Surveillance, Epidemiology, and End Results database...
July 20, 2023: Hematology/oncology and Stem Cell Therapy
https://read.qxmd.com/read/37568807/long-term-adverse-effects-of-neck-radiotherapy-in-childhood-on-the-carotid-arteries-in-survivors-of-hodgkin-lymphoma
#25
JOURNAL ARTICLE
Matjaž Popit, Marjan Zaletel, Bojana Žvan, Lorna Zadravec Zaletel
INTRODUCTION: Survivors of Hodgkin lymphoma are recognized to have an increased risk of stroke and carotid artery disease owing to neck irradiation (RT). However, it remains unclear whether the vascular modifications induced by the treatment of Hodgkin lymphoma during childhood persist over the long term. METHODS: Our matched study involved 79 survivors of Hodgkin lymphoma in childhood who received neck RT and 57 healthy controls. Parameters of arterial stiffness (AS), intima-media thickness (IMT), and flow-mediated dilation (FMD) of carotid arteries were assessed using ultrasound...
August 6, 2023: Cancers
https://read.qxmd.com/read/37506608/experiences-of-and-preferences-for-self-management-among-low-grade-non-hodgkin-s-lymphoma-survivors-a-qualitative-interview-study
#26
JOURNAL ARTICLE
Nickola D Pallin, Mairead O'Connor, Alannah Gannon, John Browne, Mary R Cahill, Derville O'Shea
PURPOSE: Supporting self-management is one strategy to help cancer survivors optimise their quality of life. Low grade non-Hodgkin's lymphoma is often incurable with a chronic disease trajectory requiring lifelong self-management. This study explored the views on self-management and preferences for self-management support among survivors of low grade non-Hodgkin's lymphoma and their informal caregivers more than 6 months after completion of systemic anti-cancer therapy. METHOD: In-depth semi-structured telephone interviews were conducted...
June 30, 2023: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/37458553/-challenges-of-long-term-follow-up-for-hodgkin-lymphoma-survivors
#27
JOURNAL ARTICLE
Hervé Ghesquières
CHALLENGES OF LONG-TERM FOLLOW UP FOR HODGKIN LYMPHOMA SURVIVORS. Challenge of Hodgkin lymphoma care is to obtain a high level of curability and minimize acute toxicities and long-term complications of chemotherapy and radiotherapy. A specific long-term multi-disciplinary follow-up should be organize with an important place of general practitioners. The follow-up concerns the risk of second cancer especially breast cancer and treatment-related cardiovascular diseases. In addition, a careful attention concerns some possible negative effects of the disease and treatments on psychosocial status and quality of life of Hodgkin lymphoma survivors...
June 2023: La Revue du Praticien
https://read.qxmd.com/read/37449925/children-s-oncology-group-s-2023-blueprint-for-research-non-hodgkin-lymphoma
#28
JOURNAL ARTICLE
Nader Kim El-Mallawany, Sarah Alexander, Mark Fluchel, Robert J Hayashi, Eric J Lowe, Lisa Giulino-Roth, Birte Wistinghausen, Michelle Hermiston, Carl E Allen
Pediatric non-Hodgkin lymphoma (NHL) includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the United States. Improvements in survival in NHL over the past 5 decades align with the overall success of the cooperative trial model with dramatic improvements in outcomes. As an example, survival for advanced Burkitt lymphoma is now >95%. Major remaining challenges include survival for relapsed and refractory disease and long-term morbidity in NHL survivors. Langerhans cell histiocytosis (LCH) was added to the NHL Committee portfolio in recognition of LCH as a neoplastic disorder and the tremendous unmet need for improved outcomes...
September 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37448267/-endocrine-disorders-after-combined-chemoradiotherapy-in-hodgkin-lymphoma-survivors
#29
JOURNAL ARTICLE
M S Voytko, V V Klimontov, T I Pospelova, Y Y Shebunyaeva, O N Fazullina
BACKGROUND: Hodgkin's lymphoma (HL) is one of the most common malignant lymphoproliferative diseases. Chemotherapy and radiotherapy used in the treatment of LH induce a number of toxic effects leading to dysfunction of endocrine system. Hormonal disorders in HL and their relationships with the therapy used remain to be clarified. AIM: To assess disorders of the endocrine function of thyroid, parathyroid glands and gonads in HL survivors. MATERIALS AND METHODS: Screening of endocrine dysfunction of the thyroid, parathyroid glands and gonads was performed in 160 adult patients with HL, 55 men and 105 women, at remission stage induced by chemotherapy or chemoradiotherapy...
May 11, 2023: Problemy E̊ndokrinologii
https://read.qxmd.com/read/37307213/retrospective-characterization-of-nodal-marginal-zone-lymphoma
#30
REVIEW
Robert Stuver, Esther Drill, David Qualls, Michelle Okwali, Connie Lee Batlevi, Philip C Caron, Ahmet Dogan, Zachary D Epstein-Peterson, Lorenzo Falchi, Paul A Hamlin, Steven M Horwitz, Brandon S Imber, Andrew M Intlekofer, William T Johnson, Niloufer Khan, Anita Kumar, Oscar B Lahoud, Jennifer Kimberly Lue, Matthew J Matasar, Alison J Moskowitz, Ariela Noy, Colette N Owens, M Lia Palomba, Heiko Schöder, Santosha A Vardhana, Joachim Yahalom, Andrew D Zelenetz, Gilles Salles, David J Straus
Nodal marginal zone lymphoma (NMZL) is a rare non-Hodgkin B-cell lymphoma that has historically been difficult to define, though is now formally recognized by the World Health Organization Classification. To better characterize the clinical outcomes of patients with NMZL, we reviewed a sequential cohort of 187 patients with NMZL to describe baseline characteristics, survival outcomes, and time-to-event data. Initial management strategies were classified into five categories: observation, radiation, anti-CD20 monoclonal antibody therapy, chemoimmunotherapy, or other...
September 12, 2023: Blood Advances
https://read.qxmd.com/read/37260445/testicular-dysfunction-at-diagnosis-in-children-and-teenagers-with-haematopoietic-malignancies-improves-after-initial-chemotherapy
#31
JOURNAL ARTICLE
Jimena Lopez Dacal, Silvina Prada, Lourdes Correa Brito, Maria Gabriela Ropelato, Maria Gabriela Ballerini, Maria Eugenia Rodriguez, Marcela E Gutiérrez, Marcela Soria, Lorena Morán, Cristina Ferraro, Patricia Bedecarrás, Guillermo Drelichman, Luis Aversa, Ignacio Bergadá, Rodolfo A Rey, Romina P Grinspon
INTRODUCTION: Hematopoietic malignancies are the most frequent type of cancer in childhood. Recent advances in cancer treatment have significantly improved survival until adulthood. There is an extensive literature on the effects of cancer treatment on the gonadal axis in adult survivors of childhood cancer mainly focused on sperm production, but scarce information exists on the immediate impact of cancer and its treatment in boys. OBJECTIVES: In this work, we determined the status of the hypothalamic-pituitary-testicular (HPT) axis function at diagnosis and the immediate impact of chemotherapy at the start of treatment in children and adolescents with hematopoietic malignancies...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37182536/cumulative-burden-of-late-major-surgical-intervention-in-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study-ccss-cohort
#32
JOURNAL ARTICLE
Bryan V Dieffenbach, Andrew J Murphy, Qi Liu, Duncan C Ramsey, Erik J Geiger, Lisa R Diller, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Yutaka Yasui, Gregory T Armstrong, Eric J Chow, Brent R Weil, Christopher B Weldon
BACKGROUND: Multimodal cancer therapy places childhood cancer survivors at increased risk for chronic health conditions, subsequent malignancies, and premature mortality as they age. We aimed to estimate the cumulative burden of late (>5 years from cancer diagnosis), major surgical interventions among childhood cancer survivors, compared with their siblings, and to examine associations between specific childhood cancer treatments and the burden of late surgical interventions. METHODS: We analysed data from the Childhood Cancer Survivor Study (CCSS), a retrospective cohort study with longitudinal prospective follow-up of 5-year survivors of childhood cancer (diagnosed before age 21 years) treated at 31 institutions in the USA, with a comparison group of nearest-age siblings of survivors selected by simple random sampling...
May 11, 2023: Lancet Oncology
https://read.qxmd.com/read/37180802/late-onset-doxorubicin-induced-congestive-heart-failure-in-an-elderly-cancer-survivor-a-case-report
#33
Hirotaka Suto, Makiko Suto, Yumiko Inui, Atsuo Okamura
BACKGROUND: Recently, the survival rate of patients with cancer has improved annually due to advancements in cancer diagnosis and treatment technologies. Meanwhile, late-onset complications associated with cancer treatment significantly affect survival and quality of life. However, different from pediatric cancer survivors, there is no unified view on the follow-up of late complications in elderly cancer survivors. We reported a case of congestive heart failure as a late-onset complication of doxorubicin (DXR) in an elderly cancer survivor...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37178052/radiation-induced-sarcomas-following-childhood-cancer-a-canadian-sarcoma-research-and-clinical-collaboration-study-cansarcc
#34
JOURNAL ARTICLE
Marina Parisi Dutra, Caroline Mary Rodrigues, Hagit Peretz-Soroka, Mauricio Ribeiro, David Shultz, David Hodgson, Derek S Tsang, Abha A Gupta
BACKGROUND: Radiation-induced sarcoma (RIS) is a late toxicity of radiation therapy (RT) usually associated with poor prognosis. Due to ongoing improvements in childhood cancer treatment and patient outcomes, RIS may become more prevalent notwithstanding evolving indications for RT. Due to limited reported studies, we sought to review our experience with RIS in survivors of pediatric cancer. METHODOLOGY: Data were collected on RIS patients following treatment for childhood cancer (initial diagnosis <18 years) identified in the CanSaRCC database...
June 2023: Cancer reports
https://read.qxmd.com/read/37168378/estimating-complete-cancer-prevalence-in-europe-validity-of-alternative-vs-standard-completeness-indexes
#35
JOURNAL ARTICLE
Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis
INTRODUCTION: Comparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach. METHODS: Within this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from US-SEER cancer registries...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37119033/reproduction-patterns-among-classical-hodgkin-lymphoma-survivors-treated-with-beacopp-and-abvd-in-sweden-denmark-and-norway-a-population-based-matched-cohort-study
#36
JOURNAL ARTICLE
Joshua P Entrop, Caroline E Weibull, Karin E Smedby, Lasse H Jakobsen, Andreas K Øvlisen, Daniel Molin, Ingrid Glimelius, Anna Marklund, Harald Holte, Alexander Fosså, Knut B Smeland, Tarec C El-Galaly, Sandra Eloranta
Childbirth rates in classical Hodgkin lymphoma (cHL) survivors have historically been reduced compared to the general population. Understanding if contemporary treatment protocols are associated with reduced fertility is crucial as treatment guidelines shift toward more liberal use of intensive chemotherapy. We identified 2834 individuals aged 18-40 years with cHL in Swedish and Danish lymphoma registers, and in the clinical database at Oslo University Hospital diagnosed 1995-2018, who were linked to national medical birth registers...
August 15, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37043087/health-related-quality-of-life-in-early-stage-hodgkin-lymphoma-a-longitudinal-analysis-of-the-abvd-arm-in-the-randomized-controlled-trial-hd-6
#37
JOURNAL ARTICLE
Hira Mian, Jolie Ringash, Ralph Meyer, Annette E Hay, Lois Shepherd, Marina Djurfeldt, Jane N Winter, Jonathan Sussman, Joseph Pater, Bingshu E Chen, Anca Prica
Early-stage Hodgkin lymphoma has become one of the most curable hematologic malignancies. Depending upon the disease location, possible toxicities, and patient preference, chemotherapy alone with ABVD remains an accepted treatment modality for this disease. There remains a paucity of data regarding the longitudinal trajectory of health-related quality of life (HRQoL) in patients treated for HL. The impact of disease and treatment on HRQoL is increasingly important to understand as the number of long-term survivors increases...
April 12, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37039661/work-and-education-interruption-in-long-term-hodgkin-lymphoma-survivors-an-analysis-among-patients-from-nine-eortc-lysa-trials
#38
JOURNAL ARTICLE
Sidsel J Juul, Sára Rossetti, Michal Kicinski, Marleen A E van der Kaaij, Francesco Giusti, Paul Meijnders, Berthe M P Aleman, John M M Raemaekers, Hanneke C Kluin-Nelemans, Michele Spina, Christophe Fermé, Loïc Renaud, Olivier Casasnovas, Aspasia Stamatoullas, Marc André, Fabien Le Bras, Wouter J Plattel, Michel Henry-Amar, Martin Hutchings, Maja V Maraldo
BACKGROUND: Disease-specific studies on the impact of Hodgkin lymphoma (HL) on education or work interruption and resumption are lacking. MATERIAL AND METHODS: In a cross-sectional study conducted among long-term HL survivors enrolled from 1964 to 2004 in nine randomised EORTC-LYSA trials, the interruption and resumption of education/work was investigated. Survivors alive 5-44 years after diagnosis who were studying or working at time of diagnosis were included ( n  = 1646)...
April 11, 2023: Acta Oncologica
https://read.qxmd.com/read/36934306/long-term-outcomes-in-hodgkin-lymphoma-survivors-temporary-trends-and-comparison-with-general-population
#39
JOURNAL ARTICLE
Beatriz Núñez-García, Mariola Blanco Clemente, Juan Cristóbal Sánchez, Ana Royuela, Blanca Cantos Sánchez de Ibargüen, Miriam Méndez, Jorge V López-Ibor, Marta Martínez, Cristina Traseira, Yago Garitaonaindia, Ramón Aguado, Virginia Calvo, María Torrente, Consuelo Parejo, Zaida Provencio, Mariano Provencio
The high cure rates of Hodgkin lymphoma (HL) make this oncological disease among those with the greatest number of long-term survivors. This single-institution study including 383 HL patients with up to 45 years of follow-up, analyses the morbidity and mortality of this population after treatments in comparison with the overall Spanish population, and investigates whether it has changed over time stratifying by periods of time, as a consequence of therapeutic optimization. The median age was 34.8 years (range 15-87) with median overall survival of 30 years, significantly higher in women (HR 0...
March 19, 2023: Hematological Oncology
https://read.qxmd.com/read/36932342/characteristics-and-clinical-course-of-thyroid-abnormalities-arisen-in-long-term-survivors-of-childhood-cancer
#40
JOURNAL ARTICLE
Hye Young Jin, Jun Ah Lee, Meerim Park, Dong-Eun Lee, Hyeon Jin Park
BACKGROUND: Thyroid abnormality is a common late effect seen in childhood cancer survivors (CCSs). We analyzed the prevalence and risk factors of thyroid abnormalities based on diagnoses and treatment modalities in CCSs. METHODS: The medical records of 257 CCSs who were diagnosed with cancer less than 20 year of age were retrospectively reviewed. The median age was 11.8 years (0.1-19.8). The median follow-up period after completion of therapy was 9...
March 18, 2023: BMC Pediatrics
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