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Survivors of Hodgkin's Disease

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https://www.readbyqxmd.com/read/28332991/accelerated-total-lymphoid-irradiation-containing-salvage-regimen-for-patients-with-refractory-and-relapsed-hodgkin-lymphoma-20%C3%A2-years-of-experience
#1
Andreas Rimner, Shona Lovie, Meier Hsu, Monica Chelius, Zhigang Zhang, Karen Chau, Alison J Moskowitz, Matthew Matasar, Craig H Moskowitz, Joachim Yahalom
PURPOSE: We report the long-term results of integrated accelerated involved field radiation therapy (IFRT) followed by total lymphoid irradiation (TLI) as part of the high-dose salvage regimen followed by autologous bone marrow transplantation or autologous stem cell transplantation in patients with relapsed or refractory Hodgkin lymphoma (HL). METHODS AND MATERIALS: From November 1985 to July 2008, 186 previously unirradiated patients with relapsed or refractory HL underwent salvage therapy on 4 consecutive institutional review board-approved protocols...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28315200/radiation-induced-cardiovascular-disease
#2
REVIEW
Deepa Raghunathan, Misha Iftikhar Khilji, Saamir A Hassan, Syed Wamique Yusuf
PURPOSE OF REVIEW: Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This review summarizes the pathology, incidence, clinical presentation, and management of cardiac events after radiation therapy. RECENT FINDINGS: Mediastinal radiation therapy accelerates the atherosclerosis process, resulting in early onset coronary artery disease...
May 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28240973/late-relapse-of-classical-hodgkin-lymphoma-an-analysis-of-the-german-hodgkin-study-group-hd7-to-hd12-trials
#3
Paul J Bröckelmann, Helen Goergen, Charlotte Kohnhorst, Bastian von Tresckow, Alden Moccia, Jana Markova, Julia Meissner, Andrea Kerkhoff, Wolf-Dieter Ludwig, Michael Fuchs, Peter Borchmann, Andreas Engert
Purpose Clinical characteristics, therapeutic approaches, and prognosis of late relapse (LR) in patients with classic Hodgkin lymphoma (cHL) are poorly understood. We performed a comprehensive analysis of LR of Hodgkin lymphoma (LR-HL). Methods To estimate the incidence of LR-HL, we retrospectively analyzed 6,840 patients with cHL included in the German Hodgkin Study Group trials HD7 to HD12. Patients who experienced a relapse > 5 years into remission were compared with patients in continued remission for > 5 years and with those who experienced a relapse ≤ 5 years after first diagnosis...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28213927/long-term-hospitalisation-rates-among-5-year-survivors-of-hodgkin-lymphoma-in-adolescence-or-young-adulthood-a-nationwide-cohort-study
#4
Kathrine Rugbjerg, Maja Maraldo, Marianne C Aznar, David J Cutter, Sarah C Darby, Lena Specht, Jørgen H Olsen
In the present study, we report on the full range of physical diseases acquired by survivors of Hodgkin lymphoma diagnosed in adolescence or young adulthood. In a Danish nationwide population-based cohort study, 1,768 five-year survivors of Hodgkin lymphoma diagnosed at ages 15-39 years during 1943-2004 and 228,447 comparison subjects matched to survivors on age and year of birth were included. Hospital discharge diagnoses and bed-days during 1977-2010 were obtained from the Danish Patient Register for 145 specific disease categories gathered in 14 main diagnostic groups...
February 18, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28156591/symptom-burdens-and-coping-strategies-in-adolescent-and-young-adult-aya-cancer-survivors-with-hematologic-malignancies
#5
Lori S Muffly, Joseline X Gomez, Kate Breitenbach, Jennifer Lynn McNeer, Wendy Stock, Christopher Daugherty
256 Background: Prior research reveals that AYA survivors face significant short-term and long-term physical and psychological symptom burdens (SB) as a result of disease and treatment. Yet, the prevalence of SB and their effect on AYA coping in hematologic survivors has not been described. METHODS: AYA patients (15-40 years at diagnosis) of acute leukemia, aggressive non-Hodgkin lymphoma, and Hodgkin lymphoma undergoing curative intent therapy (on-treatment cohort) or 2 year completion of therapy and in remission (early survivor cohort) completed following measures: depression (CES-D), state anxiety (STAI-S), PTSD (PCL-C), HRQOL (FACIT-G), Coping (Brief COPE)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28028762/screening-for-thyroid-cancer-in-survivors-of-childhood-and-young-adult-cancer-treated-with-neck-radiation
#6
Emily S Tonorezos, Dana Barnea, Chaya S Moskowitz, Joanne F Chou, Charles A Sklar, Elena B Elkin, Richard J Wong, Duan Li, R Michael Tuttle, Deborah Korenstein, Suzanne L Wolden, Kevin C Oeffinger
BACKGROUND: The optimal method of screening for thyroid cancer in survivors of childhood and young adult cancer exposed to neck radiation remains controversial. Outcome data for a physical exam-based screening approach are lacking. METHODS: We conducted a retrospective review of adult survivors of childhood and young adult cancer with a history of neck radiation followed in the Adult Long-Term Follow-Up Clinic at Memorial Sloan Kettering between November 2005 and August 2014...
December 27, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27991731/novel-treatment-concepts-in-hodgkin-lymphoma
#7
REVIEW
I Glimelius, A Diepstra
Treatment of classical Hodgkin's lymphoma (HL) has been a success story, with cure of localized disease with radiotherapy in the 1930s, cure of advanced stages with combination chemotherapy with/without radiotherapy in the mid-1960s and continuous improvements since then. Nonetheless, at present approximately 2% of patients with classical HL are primarily refractory to conventional therapy with only 50% becoming long-term survivors. Another 13% of patients relapse, with only 60% being alive 10 years postrecurrence (as exemplified in this review in a Swedish cohort of 18- to 65-year-old patients diagnosed during the period 1992-2009)...
December 19, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27987198/breast-cancer-following-radiation-for-hodgkin-lymphoma-clinical-scenarios-and-risk-reducing-strategies
#8
REVIEW
Linda Overholser, Elena Shagisultanova, Rachel A Rabinovitch, Nicole Kounalakis, Jennifer Diamond, Christina A Finlayson, Christine M Fisher, Peter Kabos, Anthony D Elias, Virginia F Borges, Jose Mayordomo
Since most patients with Hodgkin lymphoma survive their disease, long-term issues such as development of second primary malignancies arise, especially in patients treated with multimodal therapy including radiation therapy plus chemotherapy. The risk of breast cancer is significantly elevated in women exposed to high-dose ionizing radiation to the chest before age 40. The case of a 48-year-old patient with a lump in her right breast is presented as a clinical scenario in this article. We review available strategies for screening and risk reduction through chemoprevention or risk-reducing surgery, as well as challenges for management of breast cancer in patients with prior exposure to radiation for Hodgkin lymphoma...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27981896/screening-of-renal-dysfunction-among-burkitt-lymphoma-survivors-by-novel-markers
#9
Laila Metwaly Sherief, Doaa Mohammed Youssef, Hanan Saker Sherbiny, Elhamy Abdelkhalek, Mohamed Talaat, Naglaa Ali Khalifa
BACKGROUND: Burkitt lymphoma (BL) represents the most common pathological type of non-Hodgkin lymphoma in our region. Recently, high success rates have been achieved in BL treatment. Little is known about long-term renal dysfunction in this vulnerable group. In the present study, we tried to detect early chronic kidney diseases (CKD) among BL survivors by using novel screening modalities. PATIENTS AND METHODS: we investigated 53 children (aged 10 ± 2.8 years, 34 boys) who successfully treated for Burkitt lymphoma, based on LMB96 protocol, as "patient group" and 30 children as control...
December 16, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27939180/long-term-morbidity-after-staging-laparotomy-for-hodgkin-s-lymphoma
#10
Inna Lobeck, Beth Rymeski, Karen Burns, Rajaram Nagarajan, Judy Correll, Debra Kent, Roshni Dasgupta
BACKGROUND: A large cohort of Hodgkin's lymphoma (HL) survivors exist. With patients transitioning from pediatric to adult care, practitioners should be aware of potential complications. The aim of this study was to describe the long-term complications of patients who had staging laparotomy for the treatment of HL. METHODS: After institutional review board approval, a retrospective review of hospital records at our institution was performed. Data extracted included demographics, treatment course and long-term postoperative complications...
December 2, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27913498/long-term-risk-of-second-malignancy-and-cardiovascular-disease-after-hodgkin-lymphoma-treatment
#11
Flora E van Leeuwen, Andrea K Ng
Long-term survivors of Hodgkin lymphoma (HL) experience several late adverse effects of treatment, with second malignant neoplasms (SMNs) and cardiovascular diseases (CVDs) being the leading causes of death in these patients. Other late effects have also been identified, such as pulmonary dysfunction, endocrinopathies (thyroid dysfunction, infertility), neck muscle atrophy, and persistent fatigue. HL survivors have two- to fourfold increased risks to develop SMNs and CVD compared with the general population...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27860222/late-outcomes-of-adult-survivors-of-childhood-non-hodgkin-lymphoma-a-report-from-the-st-jude-lifetime-cohort-study
#12
Matthew J Ehrhardt, John T Sandlund, Nan Zhang, Wei Liu, Kirsten K Ness, Nickhill Bhakta, Wassim Chemaitilly, Kevin R Krull, Tara M Brinkman, Deborah B Crom, Larry Kun, Sue C Kaste, Gregory T Armstrong, Daniel M Green, Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Daniel A Mulrooney
BACKGROUND: Survivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors. METHOD: Chronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data...
November 15, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27821538/cardiac-mortality-among-200%C3%A2-000-five-year-survivors-of-cancer-diagnosed-at-15-to-39-years-of-age-the-teenage-and-young-adult-cancer-survivor-study
#13
Katherine E Henson, Raoul C Reulen, David L Winter, Chloe J Bright, Miranda M Fidler, Clare Frobisher, Joyeeta Guha, Kwok F Wong, Julie Kelly, Angela B Edgar, Martin G McCabe, Jeremy Whelan, David J Cutter, Sarah C Darby, Mike M Hawkins
BACKGROUND: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used. METHODS: The Teenage and Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors of cancer diagnosed at 15 to 39 years of age in England and Wales from 1971 to 2006, and followed to 2014...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27612583/cancer-related-fatigue-in-patients-with-and-survivors-of-hodgkin-s-lymphoma-a-longitudinal-study-of-the-german-hodgkin-study-group
#14
Stefanie Kreissl, Horst Mueller, Helen Goergen, Axel Mayer, Corinne Brillant, Karolin Behringer, Teresa Veronika Halbsguth, Felicitas Hitz, Martin Soekler, Oluwatoyin Shonukan, Jens Ulrich Rueffer, Hans-Henning Flechtner, Michael Fuchs, Volker Diehl, Andreas Engert, Peter Borchmann
BACKGROUND: Patients with Hodgkin's lymphoma might have persistent fatigue even years after treatment. However, knowledge of the development of fatigue persisting long after completion of treatment is limited. Therefore, we did a detailed analysis of fatigue in our first-line clinical trials for early-stage favourable (HD13 trial), early-stage unfavourable (HD14 trial), and advanced-stage (HD15 trial) Hodgkin's lymphoma. Beyond the description of fatigue from diagnosis up to 5 years after treatment, we aimed to assess any effect of patient characteristics, disease characteristics, or treatment characteristics on persistent fatigue...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27531538/gastric-cancer-clinical-and-epidemiological-aspects
#15
REVIEW
Marino Venerito, Alexander Link, Theodoros Rokkas, Peter Malfertheiner
Gastric cancer (GC) ranks fifth for cancer incidence and second for cancer deaths. Epidemiological data showed that survivors of Hodgkin's lymphoma and patients with pernicious anemia etiologically linked to autoimmune gastritis are at increased risk of GC. Screening of patients with autoimmune thyroid disease by means of pepsinogen (PG) I and PG I/II detected autoimmune gastritis with oxyntic gastric atrophy in one of four patients and may be recommended for GC prevention purposes. The International Agency for Research on Cancer reported a positive association between consumption of processed meet and increased GC risk...
September 2016: Helicobacter
https://www.readbyqxmd.com/read/27496313/hodgkin-lymphoma-late-effects-of-treatment-and-guidelines-for-surveillance
#16
REVIEW
Andrea K Ng, Flora E van Leeuwen
Long-term survivors of Hodgkin lymphoma (HL) are at risk for a range of late effects, with second malignant neoplasm and cardiovascular diseases being the leading causes of death in these patients. The excess risks remain significantly elevated decades after treatment, and are clearly associated with extent of treatment exposures. Other late effects have also been identified, such as pulmonary dysfunction, endocrinopathies, muscle atrophy, and persistent fatigue. Systemic documentation of late effects and recognition of treatment- and patient-related risk factors are important, as they inform optimal surveillance and risk-reduction strategies, as well as guide therapeutic modifications in newly diagnosed patients to minimize treatment-related complications...
2016: Seminars in Hematology
https://www.readbyqxmd.com/read/27405732/seven-year-follow-up-for-energy-vitality-outcomes-in-early-stage-hodgkin-s-disease-patients-treated-with-subtotal-lymphoid-irradiation-versus-chemotherapy-plus-radiation-swog-s9133-and-its-qol-companion-study-s9208
#17
Carol M Moinpour, Joseph M Unger, Patricia A Ganz, Alice B Kornblith, Ellen R Gaynor, Mindy Ann Bowers, Gretchen S Gatti, Mark S Kaminski, Harry Paul Erba, Ting Wang, Jihye Yoon, Oliver W Press, Richard I Fisher
PURPOSE: We describe 7 years of follow-up for the energy/vitality outcome in early-stage Hodgkin's disease patients treated on a randomized clinical trial that compared subtotal lymphoid irradiation (STLI) with combined modality treatment (CMT) (SWOG 9133). Survivorship research questions involved the extent to which symptoms/side effects endured over a follow-up period of 7 years for this early-stage patient group. METHODS: Two hundred thirty-nine patients participated in the quality of life (QOL) companion study (SWOG 9208) and completed the SF-36 vitality scale, SF-36 health perception item, Cancer Rehabilitation Evaluation System-Short Form (CARES-SF), and symptom distress scale...
February 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27391367/what-is-known-and-unknown-about-chemotherapy-related-cognitive-impairment-in-patients-with-haematological-malignancies-and-areas-of-needed-research
#18
REVIEW
Annalynn M Williams, Clive S Zent, Michelle C Janelsins
Cancer-related cognitive impairment (CRCI) is an important clinical problem for cancer patients and survivors. In this review, we summarize studies investigating the occurrence of impaired cognition in patients with haematological malignancies. Most published studies focus on survivors of childhood acute lymphoblastic leukaemia and primary central nervous system lymphoma. We also discuss studies conducted in acute myeloid leukaemia, myelodysplastic syndromes, chronic myeloid leukaemia, Hodgkin lymphoma (HL), non-HL and chronic lymphocytic leukaemia...
September 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27379565/quality-of-life-is-similar-between-long-term-survivors-of-indolent-and-aggressive-non-hodgkin-lymphoma
#19
Anne W Beaven, Greg Samsa, Sheryl Zimmerman, Sophia K Smith
Differences in quality of life (QOL) of long-term survivors of aggressive or indolent subtypes of non-Hodgkin lymphoma (NHL) have not been frequently evaluated. We assessed these differences by analyzing results of a large QOL survey of long-term NHL survivors. We hypothesized that the incurable nature of indolent NHL would relate to worse QOL in long-term survivors while the potentially cured long-term survivors of aggressive lymphoma would have better QOL. We found that QOL was similar between the two groups...
July 2, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27377470/risk-of-second-primary-malignancies-among-cancer-survivors-in-the-united-states-1992-through-2008
#20
Nicholas Donin, Christopher Filson, Alexandra Drakaki, Hung-Jui Tan, Alex Castillo, Lorna Kwan, Mark Litwin, Karim Chamie
BACKGROUND: In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. METHODS: The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, uterus, kidney, melanoma, and non-Hodgkin lymphoma) between 1992 and 2008 from Surveillance, Epidemiology, and End Results data...
October 2016: Cancer
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