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https://www.readbyqxmd.com/read/28641326/a-technical-diving-related-burns-case-treatment-in-a-remote-location
#1
Fiona C Sharp, Martin Dj Sayer
Injuries suffered as a result of a rebreather oxygen explosion and fire occurred to a diver on vacation in the island state of Chuuk, Micronesia. The medical and logistical management of the diver in a remote location are described. The mechanism of both the fire and the subsequent blast and burn injuries are discussed. Prevention of and preparation for such incidents are discussed in the context of the increasing frequency of dive and adventure travel to remote areas.
June 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28640997/from-1d-polymers-to-2d-polymers-preparation-of-free-standing-single-monomer-thick-two-dimensional-conjugated-polymers-in-water
#2
Na Zhang, Taisheng Wang, Xing Wu, Chen Jiang, Taiming Zhang, Bangkun Jin, Hengxing Ji, Wei Bai, Ruke Bai
Recently, investigation on two-dimensional (2D) organic polymers has been made a great progress and conjugated 2D polymers already play a dynamic role in both academic and practical applications. However, a convenient, non-interfacial approach to obtain single-layer 2D polymers in solution, especially in aqueous media remains challenging. Herein, we present a facile, highly efficient and versatile "1D to 2D" strategy for preparation of free-standing single-monomer-thick conjugated 2D polymers in water without any aid...
June 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28640982/mechanisms-of-sphingosine-1-phosphate-mediated-vasoconstriction-of-rat-afferent-arterioles
#3
Zhengrong Guan, Fuchenchu Wang, Xiangqin Cui, Edward W Inscho
AIM: Sphingosine-1-phosphate (S1P) influences resistance vessel function and is implicated in renal pathological processes. Previous studies revealed that S1P evoked potent vasoconstriction of the preglomerular microvasculature, but the underlying mechanisms remain incompletely defined. We postulated that S1P-mediated preglomerular microvascular vasoconstriction involves activation of voltage-dependent L-type calcium channels (L-VDCC) and the rho/rho kinase pathway. METHODS: Afferent arteriolar reactivity was assessed in vitro using the blood-perfused rat juxtamedullary nephron preparation and diameter was measured during exposure to physiological and pharmacological agents...
June 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636884/major-achievements-of-evidence-based-traditional-chinese-medicine-in-treating-major-diseases
#4
REVIEW
Jung Chao, Yuntao Dai, Robert Verpoorte, Wing Lam, Yung-Chi Cheng, Li-Heng Pao, Wei Zhang, Shilin Chen
A long history of use and extensive documentation of the clinical practices of traditional Chinese medicine resulted in a considerable number of classical preparations, which are still widely used. This heritage of our ancestors provides a unique resource for drug discovery. Already, a number of important drugs have been developed from traditional medicines, which in fact form the core of Western pharmacotherapy. Therefore, this article discusses the differences in drug development between traditional medicine and Western medicine...
June 18, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28636823/how-bacteria-respond-to-material-stiffness-during-attachment-a-role-of-escherichia-coli-flagellar-motility
#5
Fangchao Song, Megan E Brasch, Hao Wang, James H Henderson, Karen Sauer, Dacheng Ren
Material stiffness has been shown to have potent effects on bacterial attachment and biofilm formation, but the mechanism is still unknown. In this study, response to material stiffness by Escherichia coli during attachment was investigated with biofilm assays and cell tracking using the Automated Contour-base Tracking for In Vitro Environments (ACTIVE) computational algorithm. By comparing the movement of E. coli cells attached on poly(dimethylsiloxane) (PDMS) surfaces of different Young's moduli (0.1 and 2...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28636365/sustainable-elastomers-from-renewable-biomass
#6
Zhongkai Wang, Liang Yuan, Chuanbing Tang
Sustainable elastomers have undergone explosive growth in recent years, partly due to the resurgence of biobased materials prepared from renewable natural resources. However, mounting challenges still prevail: How can the chemical compositions and macromolecular architectures of sustainable polymers be controlled and broadened? How can their processability and recyclability be enabled? How can they compete with petroleum-based counterparts in both cost and performance? Molecular-biomass-derived polymers, such as polymyrcene, polymenthide, and poly(ε-decalactone), have been employed for constructing thermoplastic elastomers (TPEs)...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28636352/prevention-of-marine-biofouling-using-the-natural-allelopathic-compound-batatasin-iii-and-synthetic-analogues
#7
Lindon W K Moodie, Rozenn Trepos, Gunnar Cervin, Kari Anne Bråthen, Bente Lindgård, Rigmor Reiersen, Patrick Cahill, Henrik Pavia, Claire Hellio, Johan Svenson
The current study reports the first comprehensive evaluation of a class of allelopathic terrestrial natural products as antifoulants in a marine setting. To investigate the antifouling potential of the natural dihydrostilbene scaffold, a library of 22 synthetic dihydrostilbenes with varying substitution patterns, many of which occur naturally in terrestrial plants, were prepared and assessed for their antifouling capacity. The compounds were evaluated in an extensive screen against 16 fouling marine organisms...
June 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28636316/a-novel-melamine-o-phthalaldehyde-covalent-organic-frameworks-nanaosheets-enhancement-flame-retardant-and-mechanical-performances-of-thermoplastic-polyurethanes
#8
Xiaowei Mu, Jing Zhan, Xiaming Feng, Bihe Yuan, Shuilai Qiu, Lei Song, Yuan Hu
Covalent organic frameworks (COFs) nanosheets prepared from condensation reaction between melamine and o-phthalaldehyde are firstly prepared through ball milling and then incorporated into thermoplastic polyurethanes (TPU) by solution mixing. Transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectrometer are applied to characterize COFs nanosheets. It is observed apparently from TEM image that COFs nanosheets are obtained...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28636001/wataa-atlas-of-protein-hydration-exploring-synergies-between-data-mining-and-ab-initio-calculations
#9
Jiří Černý, Bohdan Schneider, Lada Biedermannová
Water molecules represent an integral part of proteins and a key determinant of protein structure, dynamics and function. WatAA is a newly developed, web-based atlas of amino-acid hydration in proteins. The atlas provides information about the ordered first hydration shell of the most populated amino-acid conformers in proteins. The data presented in the atlas are drawn from two sources: experimental data and ab initio quantum-mechanics calculations. The experimental part is based on a data-mining study of a large set of high-resolution protein crystal structures...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28635562/nanoformulated-natural-therapeutics-for-management-of-streptozotocin-induced-diabetes-potential-use-of-curcumin-nanoformulation
#10
Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Laila A Eissa, Ibrahim M El-Sherbiny
AIM: The goal of this study was to improve curcumin (CUR) aqueous solubility and bioavailability via nanoformulation, and then study its activity and mechanism of action as an antidiabetic agent. METHODS: CUR-loaded pluronic nanomicelles (CURnp) were prepared and characterized. Biochemical assessments were performed as well as histological, confocal and RTPCR studies on pancreatic target tissues. RESULTS: CURnp with a diameter of 333 ± 6 nm and ζ potential of -26...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635256/in-situ-gelation-induced-death-of-cancer-cells-based-on-proteinosomes
#11
Yuting Zhou, Jianmin Song, Lei Wang, Xuting Xue, Xiaoman Liu, Hui Xie, Xin Huang
Hydrogel is quite a nice kind of material, which can be utilized as the platform for cell culture. However, when bulky hydrogel was formed inside cancer cells, results would be changed. In this study, we showed a way of in situ gelation inside the cells which could induce the death of cancer cells. A glutathione (GSH) responsive proteinosomes, with nice biocompatibility, were prepared as carriers of sodium alginate to be endocytosed by cancer cells, where the chelation between sodium alginate and free calcium ions in the culture medium occurred during the diffusion process...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28635253/discovery-and-characterization-of-histidine-oxidation-initiated-cross-links-in-an-igg1-monoclonal-antibody
#12
Chong-Feng Xu, Rachel Chen, Linda Yi, Tim Brantley, Brad Stanley, Zoran Sosic, Li Zang
Novel cross-links between an oxidized histidine and intact histidine, lysine or cysteine were discovered and characterized from high-molecular weight (HMW) fractions of an IgG1 monoclonal antibody (mAb). The mAb HMW fractions were col-lected using preparative size-exclusion chromatography (SEC) and extensively characterized to understand the mechanism of formation of the non-reducible and covalently linked portion of the HMWs. The HMW fractions were IdeS digested, reduced and analyzed by size-exclusion chromatography coupled with mass spectrometry (SEC-MS)...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28634790/cellulose-acetate-butyrate-ammonio-methacrylate-copolymer-blends-as-a-novel-coating-in-osmotic-tablets
#13
R Ali, M Walther, R Bodmeier
The objective of this work was the preparation of osmotic tablets using polymer blends of cellulose acetate butyrate (CAB) or ethylcellulose with ammonio methacrylate copolymer (Eudragit® RL). The advantage of these coatings in comparison to the traditionally used cellulose acetate is their solubility in safer organic solvents like ethanol. Polymer films were characterized with respect to their water uptake, dry mass loss, and mechanical properties. The effect of the polymer blend ratio on drug release and on the rupture force of the coating was investigated...
June 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28634733/dynamic-properties-of-human-tympanic-membrane-after-exposure-to-blast-waves
#14
Warren G Engles, Xuelin Wang, Rong Z Gan
Blast overpressure causes dynamic damage to middle ear components, and tympanic membrane (TM) rupture is the most frequent middle ear injury. However, it is unclear how the blast waves change mechanical properties of the TM and affect sound transmission through the ear. This paper reports the current study on dynamic properties of the TM after exposure to blast waves by using acoustic loading and laser Doppler vibrometry (LDV). The TM specimens were prepared from human temporal bones following exposures to blast overpressure...
June 20, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28634589/hla-class-ia-and-ib-polyreactive-anti-hla-e-igg2a-monoclonal-antibodies-tfl-006-and-tfl-007-suppress-anti-hla-igg-production-by-cd19-b-cells-and-proliferation-of-cd4-t-cells-while-upregulating-tregs
#15
REVIEW
Mepur H Ravindranath
The anti-HLA-E IgG2a mAbs, TFL-006 and TFL-007, reacted with all HLA-I antigens, similar to the therapeutic preparations of IVIg. Indeed, IVIg lost its HLA reactivity, when its HLA-E reactivity was adsorbed out. US-FDA approved IVIg to reduce antibodies in autoimmune diseases. But the mechanism underlying IVIg-mediated antibody reduction could not be ascertained due to the presence of other polyclonal antibodies. In spite of it, the cost prohibitive high or low IVIg is administered to patients waiting for donor organ and for allograft recipients for lowering antiallograft antibodies...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28634397/one-pot-hydrothermal-synthesis-of-cds-decorated-cus-microflower-like-structures-for-enhanced-photocatalytic-properties
#16
Xiaolong Deng, Chenggang Wang, Hongcen Yang, Minghui Shao, Shouwei Zhang, Xiao Wang, Meng Ding, Jinzhao Huang, Xijin Xu
CdS decorated CuS structures have been controllably synthesized through a one-pot hydrothermal method. The morphologies and compositions of the as-prepared samples could be concurrently well controlled by simply tuning the amount of CdCl2 and thiourea. Using this strategy, the morphology of the products experienced from messy to flower-like morphologies with multiple porous densities, together with the phase evolution from pure CuS to the CdS/CuS composites. Serving as a photocatalyst, the samples synthesized with the addition of 1 mmol cadmium chloride and 3 mmol thiourea during synthetic process, showed the best photocatalytic activity, which could reach a maximum photocatalytic efficiency of 93% for methyl orange (MO) photodegradation after 150 min...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634141/one-step-preparation-of-spherical-drug-particles-by-contamination-free-dry-milling-technique-with-corn-starch-beads
#17
Toshiyuki Niwa, Maria Yoshida, Naoko Hayashi, Keita Kondo
The novel dry milling technique has been developed by using a mechanical powder processor for improving the dissolution properties of poorly water-soluble drugs. It was found that the drug crystals were well pulverized by co-processing with fine particles of corn starch (CS). The morphological observation and particle size evaluation revealed that the processed products formed the composite particles with ordered-mixed structure, having double-layered particles with a core of CS and a coating layer of phenytoin (Phe), as a model drug...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28634136/tongxie-formula-reduces-symptoms-of-irritable-bowel-syndrome
#18
Heng Fan, Liang Zheng, Yaoliang Lai, Weimin Lu, Zhixiang Yan, Qi Xiao, Baiwen Li, Min Tang, Dawei Huang, Yuanyuan Wang, Zhen Li, Yuwei Mei, Zhengyan Jiang, Xingxing Liu, Qing Tang, Dongmei Zuo, Jingyi Ye, Yongqiang Yang, Huisuo Huang, Zongxiang Tang, Jun Xiao
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is the most common chronic gastrointestinal disorder, yet few drugs are effective in reducing symptoms. Approximately 50% of patients with IBS attempt herbal therapy at least once. We performed a randomized controlled trial to compare the efficacy of the herb formulation tongxie vs placebo or pinaverium (an antispasmodic agent) in reducing symptoms of IBS. METHODS: We performed a trial of 1044 adult patients with IBS (based on Rome III criteria) at 5 hospitals in China, from August 2012 through January 2015...
June 17, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28633831/the-effects-of-organoclay-on-the-morphology-and-mechanical-properties-of-pai-clay-nanocomposites-coatings-prepared-by-the-ultrasonication-assisted-process
#19
Hamed Naderi-Samani, Reza Shoja Razavi, Mohammad Reza Loghman-Estarki, Mazaher Ramazani
In this research, solvent based polyamide - imide (PAI)/clay nanocomposites were prepared successfully using the solution dispersion technique. With the assistance of the ultrasonic wave, the effect of the ultrasonic wave time on the microstructure of 3wt% PAI/C20A nanocomposite (NC) was investigated. Then, the best ultrasonic parameters were selected and the effects of the concentration of Cloisite 20A (C20A) (1, 3 and 5wt% C20A) on the microstructure and mechanical properties (adhesion, hardness, flexibility, wear and impact) of NCs were investigated...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633818/insight-into-the-synthesis-procedure-of-fe-3-tio2-based-photocatalyst-applied-in-the-selective-photo-oxidation-of-benzyl-alcohol-under-sun-imitating-lamp
#20
Agnieszka Magdziarz, Juan C Colmenares, Olga Chernyayeva, Dmytro Lisovytskiy, Justyna Grzonka, Krzysztof Kurzydłowski, Kinga Freindl, Józef Korecki
Fe(3+)/TiO2/zeolite Y photocatalyst synthesized by using sonophotodeposition method was compared with photocatalysts prepared by simple photodeposition and sonodeposition methods in order to clarify the role of light irradiation and ultrasounds while they are used simultaneously. To gain an insight into the mechanism of this method a detailed characterization of the photocatalysts was carried out by means of the following techniques: UV-vis diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, Mössbauer measurements and photocatalytic test reaction...
September 2017: Ultrasonics Sonochemistry
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