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https://www.readbyqxmd.com/read/28549345/a-novel-synthetic-derivative-of-quercetin-8-trifluoromethyl-3-5-7-3-4-o-pentamethyl-quercetin-inhibits-bladder-cancer-growth-by-targeting-the-ampk-mtor-signaling-pathway
#1
Ting Tao, Caimei He, Jun Deng, Yanjun Huang, Qiongli Su, Mei Peng, Meiling Yi, Kwame Oteng Darko, Hui Zou, Xiaoping Yang
Quercetin is a naturally existing compound and shows attractive anticancer properties for a variety of solid tumors including glioma, bladder cancer, hepatocellular carcinoma, breast cancer, hematological malignancies and prostate carcinoma. However, these anticancer properties have not been clinically approved due to unclear mechanistic information and its low bioactivity. In our previous study, we elucidated that quercetin activates AMPK pathway which is the major mechanism for its unique anticancer effect in bladder cancer...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548859/separation-of-oil-in-water-emulsions-using-hydrophilic-electrospun-membranes-with-anisotropic-pores
#2
Weerapha Panatdasirisuk, Zhiwei Liao, Thammasit Vongsetskul, Shu Yang
It has been challenging to separate oil from oil/water emulsions with droplet size less than 1 μm using conventional porous membranes. Membranes with small pores are preferred, but the trade-off is a dramatic reduction of volumetric flux. Here, we prepared membranes from electrospun polycaprolactone (PCL) fibers with high porosity (∼88%). When the membranes were stretched uniaxially at different strain levels, the pores became anisotropic with an aspect ratio (pore length/width) up to 5.3 ± 3.0. To improve their wettability, we added Tween 80, a hydrophilic surfactant, to PCL solutions for electrospinning...
May 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28548178/stereospecific-control-of-the-metal-centred-chirality-of-rhodium-iii-and-iridium-iii-complexes-bearing-tetradentate-cnn-p-ligands
#3
María Carmona, Ricardo Rodríguez, Isabel Méndez, Vincenzo Passarelli, Fernando J Lahoz, Pilar García-Orduña, Daniel Carmona
Ligands LH1-LH3 have been prepared by two successive condensation/reduction steps. These ligands react with MCl3 (M = Rh, Ir) rendering the trichlorido complexes [MCl3(κ(3)N,N',P-LH)] (M = Rh, LH = LH1 (1), LH2 (2), LH3 (3); M = Ir, LH = LH1, (4)) as racemic mixtures of fac and mer isomers. Only one of the two possible fac isomers was detected. The mer isomer of the rhodium compounds 1-3 quantitatively isomerizes to the more stable fac isomer, whereas the mer isomer of the iridium complex 4 does not. DFT calculations indicate a dissociative pathway for this isomerization...
May 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28547889/comparison-between-chaotropic-and-detergent-based-sample-preparation-workflow-in-tendon-for-mass-spectrometry-analysis
#4
Yalda A Kharaz, Danae Zamboulis, Karen Sander, Eithne Comerford, Peter Clegg, Mandy Peffers
Exploring the tendon proteome is a challenging but important task for understanding the mechanisms of physiological/pathological processes during ageing and disease and for the development of new treatments. Several extraction methods have been utilised for tendon mass spectrometry, however different extraction methods have not been simultaneously compared. In the present study we compared protein extraction in tendon with two chaotropic agents, guanidine hydrochloride (GnHCl) and urea, a detergent, RapiGest(ۛ) , and their combinations for shotgun mass spectrometry...
May 26, 2017: Proteomics
https://www.readbyqxmd.com/read/28547767/wet-chemical-synthesis-of-hollow-red-phosphorus-nanospheres-with-porous-shells-as-anodes-for-high-performance-lithium-ion-and-sodium-ion-batteries
#5
Jianbin Zhou, Xianyu Liu, Wenlong Cai, Yongchun Zhu, Jianwen Liang, Kailong Zhang, Yang Lan, Zhuoheng Jiang, Gongming Wang, Yitai Qian
Large-volume-expansion-induced material pulverization severely limits the electrochemical performance of red phosphorous (P) for energy-storage applications. Hollow nanospheres with porous shells are recognized as an ideal structure to resolve these issues. However, a chemical synthetic approach for preparing nanostructured red P is always of great challenge and hollow nanosphere structures of red P have not yet been fabricated. Herein, a wet solvothermal method to successfully fabricate hollow P nanospheres (HPNs) with porous shells via a gas-bubble-directed formation mechanism is developed...
May 26, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28545871/reinforcing-effect-of-glass-fiber-mesh-on-complete-dentures-in-a-test-model-with-a-simulated-oral-mucosa
#6
Sang-Hui Yu, Seunghan Oh, Hye-Won Cho, Ji-Myung Bae
STATEMENT OF PROBLEM: Studies that evaluated the strength of complete dentures reinforced with glass-fiber mesh or metal mesh on a cast with a simulated oral mucosa are lacking. PURPOSE: The purpose of this in vitro study was to compare the mechanical properties of maxillary complete dentures reinforced with glass-fiber mesh with those of metal mesh in a new test model, using a simulated oral mucosa. MATERIAL AND METHODS: Complete dentures reinforced with 2 types of glass-fiber mesh, SES mesh (SES) and glass cloth (GC) and metal mesh (metal) were fabricated...
May 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28545818/boron-nitride-nanotubes-as-novel-fillers-for-improving-the-properties-of-dental-adhesives
#7
Felipe Weidenbach Degrazia, Vicente Castelo Branco Leitune, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
OBJECTIVE: This study aimed to evaluate the physical-chemical properties of experimental dental adhesives containing boron nitride nanotubes (BNNTs) as inorganic fillers. METHODS: An experimental adhesive resin was prepared using HEMA-BisGMA, 66/33 wt% (control). Inorganic BNNT fillers were first analyzed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and then incorporated into the adhesive at different concentration (0.05, 0...
May 22, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28545580/early-response-in-cognitive-behavior-therapy-for-syndromes-of-medically-unexplained-symptoms
#8
Maria Kleinstäuber, Michael J Lambert, Wolfgang Hiller
BACKGROUND: Early dramatic treatment response suggests a subset of patients who respond to treatment before most of it has been offered. These early responders tend to be over represented among those who are well at termination and at follow-up. Early response patterns in psychotherapy have been investigated only for a few of mental disorders so far. The main aim of the current study was to examine early response after five therapy-preparing sessions of a cognitive behavior therapy (CBT) for syndromes of medically unexplained symptoms (MUS)...
May 25, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28545375/natural-product-gossypol-and-its-derivatives-in-precision-cancer-medicine
#9
Yun Zeng, Jingwen Ma, Liang Xu, Daocheng Wu
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially used as a male contraceptive but was subsequently investigated as a novel antitumor agent. This review depicts the current status of gossypol and its derivatives as novel antitumor agents as well as presents their preparation and characteristics, especially of some gossypol Schiff bases, through quantitative and structural analyses. The main attractive target sites of gossypol and its derivatives are Bcl-2 family proteins containing the anti-apoptosis proteins Bcl-2 and Bcl-XL...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28545372/lectin-carbohydrate-interactions-implications-for-the-development-of-new-anticancer-agents
#10
Evellyne de Oliveira Figueirôa, Cassia Regina Albuquerque da Cunha, Priscilla B S Albuquerque, Raiana Apolinário de Paula, Mary Ângela Aranda-Souza, Matheus Alves da Silva, Adrielle Zagmignan, Maria G Carneiro-da-Cunha, Luís Cláudio Nascimento da Silva, Maria Tereza Dos Santos Correia
Lectins are a large group of proteins found in animals, plants, fungi, and bacteria that recognize specific carbohydrate targets and play an important role in cell recognition and communication, host-pathogen interactions, embryogenesis, and tissue development. Recently, lectins have emerged as important biomedical tools that have been used in the development of immunomodulatory, antipathogenic, and anticancer agents. Several lectins have been shown to have the ability to discriminate between normal cells and tumor cells as a result of their different glycosylation patterns...
May 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28545102/effect-of-dietary-restriction-and-subsequent-re-alimentation-on-the-transcriptional-profile-of-bovine-ruminal-epithelium
#11
Kate Keogh, Sinead M Waters, Paul Cormican, Alan K Kelly, Emma O'Shea, David A Kenny
Compensatory growth (CG) is utilised worldwide in beef production systems as a management approach to reduce feed costs. However the underlying biology regulating the expression of CG remains to be fully elucidated. The objective of this study was to examine the effect of dietary restriction and subsequent re-alimentation induced CG on the global gene expression profile of ruminal epithelial papillae. Holstein Friesian bulls (n = 60) were assigned to one of two groups: restricted feed allowance (RES; n = 30) for 125 days (Period 1) followed by ad libitum access to feed for 55 days (Period 2) or (ii) ad libitum access to feed throughout (ADLIB; n = 30)...
2017: PloS One
https://www.readbyqxmd.com/read/28544887/silver-nanoparticles-in-seawater-a-dynamic-mass-balance-at-part-per-trillion-silver-concentrations
#12
Claudio Toncelli, Kyriaki Mylona, Ioanna Kalantzi, Anastasia Tsiola, Paraskevi Pitta, Manolis Tsapakis, Spiros A Pergantis
This study investigates the dynamic processes affecting silver (Ag) nanoparticles that have been spiked into seawater at environmentally relevant concentrations (200 and 2000ngAgL(-1)). Seawater samples were taken at regular time intervals from multiple microcosm tanks and analysed rapidly, without any sample preparation, using a recently developed flow injection on-line dilution single particle inductively coupled plasma mass spectrometry method. Dissolution was found to be the predominant process of Ag nanoparticle transformation, with its rate being influenced by the type and thickness of the nanoparticle organic coating...
May 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28544657/a-strategy-to-enhance-the-efficiency-of-quantum-dot-sensitized-solar-cells-by-decreasing-the-electron-recombinations-with-polyoxometalate-tio2-as-the-electronic-interface-layer
#13
Li Chen, Wei-Lin Chen, Jian-Ping Li, Jia-Bo Wang, En-Bo Wang
The serious electron recombination occurring in TiO2/quantum dot sensitizer/electrolyte interface is the key reason for hindering the further efficiency improvement of QDSCs. Polyoxometalate(POM) can be as electron transfer media to decreasing electron recombination of photoelectric device, which is due to the excellent oxidation reduction properties and thermostability. So in this paper, POM/TiO2 electronic interface layer prepared by a simple layer-by-layer self-assembly method is added between FTO and mesoporous TiO2 in the photoanode of the QDSCs, and their effects on the photovoltaic performance are systematically investigated...
May 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28544556/electrophysiological-analysis-of-synaptic-transmission-in-drosophila
#14
REVIEW
Maria Bykhovskaia, Alexander Vasin
Synaptic transmission is dynamic, plastic, and highly regulated. Drosophila is an advantageous model system for genetic and molecular studies of presynaptic and postsynaptic mechanisms and plasticity. Electrical recordings of synaptic responses represent a wide-spread approach to study neuronal signaling and synaptic transmission. We discuss experimental techniques that allow monitoring synaptic transmission in Drosophila neuromuscular and central systems. Recordings of synaptic potentials or currents at the larval neuromuscular junction (NMJ) are most common and provide numerous technical advantages due to robustness of the preparation, large and identifiable muscles, and synaptic boutons which can be readily visualized...
May 24, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28544286/early-regional-cuprizone-induced-demyelination-in-a-rat-model-revealed-with-mri
#15
Wendy Oakden, Nicholas A Bock, Alia Al-Ebraheem, Michael J Farquharson, Greg J Stanisz
The cuprizone model of demyelination is well established in the mouse as a tool for the study of the mechanisms of both demyelination and remyelination. It is often desirable, however, to have a larger model, such as the rat, especially for imaging-based studies, yet initial work has failed to show demyelination in cuprizone-fed rats. Several recent studies have demonstrated demyelination in the rat, but only in the corpus callosum. In this study, we acquired high-resolution, three-dimensional images of the whole brain every 2 weeks, using a T1 -weighted magnetization-prepared rapid acquisition gradient echo imaging sequence, optimized for myelin contrast, in order to assess myelination across the entire rat brain over a period of 8 weeks on a 1% cuprizone diet...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28544235/absence-of-juvenile-hormone-signalling-regulates-the-dynamic-expression-profiles-of-nutritional-metabolism-genes-during-diapause-preparation-in-the-cabbage-beetle-colaphellus-bowringi
#16
W Liu, Q-Q Tan, L Zhu, Y Li, F Zhu, C-L Lei, X-P Wang
Temperate insects have evolved diapause, a period of programmed developmental arrest during specific life stages, to survive unfavourable conditions. During the diapause preparation phase (DPP), diapause-destined individuals generally store large amounts of fat by regulating nutrition distribution for the energy requirement during diapause maintenance and postdiapause development. Although nutritional patterns during the DPP have been investigated at physiological and biochemical levels in many insects, it remains largely unknown how nutritional metabolism is regulated during the DPP at molecular levels...
May 20, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28544228/synthesis-of-benzodihydrofurans-by-asymmetric-c-h-insertion-reactions-of-donor-donor-carbenoids
#17
Jared Thomas Shaw, Kellan N Lamb, Richard A Squitieri, Srinivasa R Chintala, Ada J Kwong, Edward I Balmond, Cristian Soldi, Olga Dmytrenko, Marta Castiñeira Reis, Ryan Chung, J Bennett Addison, James C Fettinger, Jason C Hein, Dean J Tantillo, Joseph M Fox
Metal carbenoids appended with two electron-donating groups, known as "donor/donor" carbenoids, undergo diastereo- and enantioselective rhodium-catalyzed C-H insertion reactions with ether substrates to form benzodihydrofurans. Unlike the reactions of carbenoids with electron-withdrawing groups attached, the attenuated electrophilicity enables these reactions to be conducted in Lewis basic solvents (e.g., acetonitrile) and in the presence of water. The diazo precursors for these species are prepared in situ from hydrazone using a mild and chemoselective oxidant (MnO2)...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28544219/mechanism-based-enantiodivergence-in-manganese-reduction-catalysis-a-chiral-pincer-complex-for-the-highly-enantioselective-hydroboration-of-ketones
#18
Lutz Gade, Hubert Wadepohl, Vladislav Vasilenko, Clemens K Blasius
A manganese alkyl complex containing a chiral "boxmi" pincer ligand is a precatalyst for a catalyst of unprecedented activity and selectivity in the enantioselective hydroboration of ketones producing preparatively useful chiral alcohols in excellent yields and up to >99 %ee. It is applicable for both aryl alkyl and dialkyl ketone reduction under mild conditions (TOF >450 h-1 at -40°C) and an earth abundant base metal catalyst which operates at very low catalyst loadings (as low as 0.1 mol%) and with a high level of functional group tolerance...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544022/covalently-modified-graphenes-in-catalysis-electrocatalysis-and-photoresponsive-materials
#19
Sergio Navalon, Jose Raul Herance, Mercedes Alvaro, Hermenegildo García
Ideal graphene is a one-atom thick single layer of carbon atoms having sp2 hybridation in hexagonal arrangement. Due to their large surface area and good dispersability in common solvents, graphenes are suitable platforms to anchor covalently units. The appended unit can introduce additional functionality to graphene. Although the field of covalently modified graphene is still starting compared to the development of other carbon nanoforms, there is alrady many examples describing the use of modified graphenes as recoverable photo-, electro- and catalysts as well as in non-linear optics and to improve mechanical resistance and solubility of graphenes...
May 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543921/correlations-of-low-field-nmr-and-variable-field-nmr-parameters-with-osteoarthritis-in-human-articular-cartilage-under-load
#20
Erik Rössler, Carlos Mattea, Simo Saarakkala, Petri Lehenkari, Mikko Finnilä, Lassi Rieppo, Sakari Karhula, Miika T Nieminen, Siegfried Stapf
NMR experiments carried out at magnetic fields below 1 T provide new relaxation parameters unavailable with conventional clinical scanners. Contrast of T1 generally becomes larger towards low fields, as slow molecular reorientation processes dominate relaxation at the corresponding Larmor frequencies. This advantage has to be considered in the context of lower sensitivity and frequently reduced spatial resolution. The layered structure of cartilage is one example where a particularly strong variation of T1 across the tissue occurs, being affected by degenerative diseases such as osteoarthritis (OA)...
May 24, 2017: NMR in Biomedicine
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