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https://www.readbyqxmd.com/read/27933670/gold-i-fluorohalides-theory-and-experiment
#1
Babil Menjón, Miguel Baya, Alberto Pérez-Bitrián, Sonia Martínez-Salvador, José María Casas, Jesús Orduna
The anionic trifluoromethyl-gold(I) derivatives [CF₃AuX]⁻, which have been prepared and isolated as their [PPh₄]⁺ salts in good yield, undergo thermally-induced difluorocarbene extrusion in the gas phase giving rise to the mixed gold(I) fluorohalide complexes [F-Au-X]⁻ (X = Cl, Br, I). These triatomic species have been detected by tandem mass spectrometry (MS2) experiments and their properties have been analyzed by DFT methods. The CF₂ extrusion mechanism from the Au-CF₃ moiety serves as a model for the CF₂ insertion into the Au-F bond, since both reactivity channels are connected by the microreversibility principle...
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27933120/fast-and-selective-cell-isolation-from-blood-sample-by-microfiber-fabric-system-with-vacuum-aspiration
#2
Takayuki Ueki, Akifumi Yoshihara, Yuji Teramura, Madoka Takai
Since circulating tumor cells (CTCs) are tumor cells which are found in the blood of cancer patients, CTCs are potential tumor markers, so a rapid isolation of CTCs is desirable for clinical applications. In this paper, a three-dimensional polystyrene (PS) microfiber fabric with vacuum aspiration system was developed for capturing CTCs within a short time. Various microfiber fabrics with different diameters were prepared by the electrospinning method and optimized for contact frequency with cells. Vacuum aspiration utilizing these microfiber fabrics could filter all cells within seconds without mechanical damage...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27932882/sustained-release-liquisolid-compact-tablets-containing-artemether-lumefantrine-as-alternate-day-regimen-for-malaria-treatment-to-improve-patient-compliance
#3
Petra Obioma Nnamani, Agatha Adaora Ugwu, Emmanuel Chinedu Ibezim, Franklin Chimaobi Kenechukwu, Paul Achile Akpa, John-Dike Nwabueze Ogbonna, Nicholas Chinedu Obitte, Amelia Ngozi Odo, Maike Windbergs, Claus-Michael Lehr, Anthony Amaechi Attama
The present study aimed to develop low-dose liquisolid tablets of two antimalarial drugs artemether-lumefantrine (AL) from a nanostructured lipid carrier (NLC) of lumefantrine (LUM) and estimate the potential of AL as an oral delivery system in malariogenic Wistar mice. LUM-NLCs were prepared by hot homogenization using Precirol(®) ATO 5/Transcutol(®) HP and tallow fat/Transcutol(®) HP optimized systems containing 3:1 ratios of the lipids, respectively, as the matrices. LUM-NLC characteristics, including morphology, particle size, zeta potential, encapsulation efficiency, yield, pH-dependent stability, and interaction studies, were investigated...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932756/-inhibitory-effect-of-jianpi-jiedu-prescription-contained-serum-on-colorectal-cancer-sw48-cell-proliferation-by-mtor-p53-p21-signalling-pathway
#4
Fengxia Lin, Sanlin Lei, Jin'an Ma, Li Shi, Dan Mao, Shaofan Zhang, Jianhua Huang, Xinyi Liu, Dengfeng Ding, Yingjin Zhang, Sifang Zhang
To investigate the effect of jianpi-jiedu (JPJD) prescription-contained serum on colorectal cancer SW48 cell proliferation and the underlying mechanisms.
 Methods: Crude extract from JPJD was made by water extract method and the main components of crude extract from JPJD were analyzed by ultra-performance liquid phase high resolution time of flight mass spectrometry (UPLC-Q-TOF/MS). The low, medium, and high-concentration of JPJD-contained serum were prepared by the serum pharmacological method. The effect of serum containing JPJD on SW48 cell proliferation was determined by MTT assay...
November 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27932027/gut-symbiotic-bacteria-stimulate-insect-growth-and-egg-production-by-modulating-hexamerin-and-vitellogenin-gene-expression
#5
Jun Beom Lee, Kyoung-Eun Park, Seung Ah Lee, Seong Han Jang, Ho Jeong Eo, Ho Am Jang, Chan-Hee Kim, Tsubasa Ohbayashi, Yu Matsuura, Yoshitomo Kikuchi, Ryo Futahashi, Takema Fukatsu, Bok Luel Lee
Recent studies have suggested that gut symbionts modulate insect development and reproduction. However, the mechanisms by which gut symbionts modulate host physiologies and the molecules involved in these changes are unclear. To address these questions, we prepared three different groups of the insect Riptortus pedestris: Burkholderia gut symbiont-colonized (Sym) insects, Burkholderia-non-colonized (Apo) insects, and Burkholderia-depleted (Sym(Burk-)) insects, which were fed tetracycline. When the hemolymph proteins of three insects were analyzed by SDS-PAGE, the hexamerin-α, hexamerin-β and vitellogenin-1 proteins of Sym-adults were highly expressed compared to those of Apo- and Sym(Burk-)-insects...
December 5, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27931851/spanish-broom-spartium-junceum-l-fibers-impregnated-with-vancomycin-loaded-chitosan-nanoparticles-as-new-antibacterial-wound-dressing-preparation-characterization-and-antibacterial-activity
#6
T Cerchiara, A Abruzzo, R A Ñahui Palomino, B Vitali, R De Rose, G Chidichimo, L Ceseracciu, A Athanassiou, B Saladini, F Dalena, F Bigucci, B Luppi
In this work, we propose as new wound dressing, the Spanish Broom fibers impregnated with vancomycin (VM) loaded chitosan nanoparticles. Spanish Broom fibers were extracted by patented method DiCoDe and the morphological, physical and mechanical properties were investigated. Chitosan nanoparticles were prepared by ionic gelation using different weight ratios between chitosan (CH) and tripolyphosphate (TPP). Nanoparticles were characterized in terms of size, zeta potential, yield, encapsulation efficiency, stability and drug release...
December 5, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27931180/characterisation-of-food-contact-non-stick-coatings-containing-tio2-nanoparticles-and-study-of-their-possible-release-into-food
#7
Viviana Golja, Goran Dražić, Martina Lorenzetti, Janja Vidmar, Janez Ščančar, Maša Zalaznik, Mitjan Kalin, Saša Novak
Novel nanoparticles containing non-stick coatings have been developed for food contact applications such as frying pans. Possible release of nanoparticles from such coatings into food is not known. In this paper, the characterisation of commercially available non-stick coatings was performed by use of FTIR, electron and optical microscopy, EDXS and XRD analysis. Characterisation revealed that the coatings contained micron- and nanosized rutile TiO2 particles, and quartz SiO2 embedded in a silicone polymer matrix...
December 9, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27930972/the-anti-hyperplasia-of-mammary-gland-effect-of-protein-extract-hss-from-tegillarca-granosa
#8
Yuping Jia, Xiu Liu, Qingwen Jia, Wei Zhang, Chao Sun, Dongdong Yuan, Haoran Zhang, Ena Jiang, Dongshun Zhou
Tegillarca granosa Linnaeus, possesses various biological functions and has been used a Chinese traditional medicine more than one century, but there is no report about anti-hyperplasia of mammary gland (HMG) activity of drugs from T. granosa. In this study, we investigated the anti-HMG effect of protein extract named HSS from T. granosa. The HMG model of virgin female Sprague Dawley rats was prepared by injecting estrogen in the thigh muscle of the rats and progestogen consecutively. HMG rats were treated with either HSS or positive control drug by i...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930884/the-effect-of-branching-star-architecture-on-poly-d-l-lactide-pdlla-degradation-and-drug-delivery
#9
Jason Burke, Roberto Donno, Richard d'Arcy, Sarah Cartmell, Nicola Tirelli
This study focuses on the comparative evaluation of star (branched) and linear poly(L,D-lactic acid) (PDLLA) as degradable materials employed in controlled release. The polymers were prepared via ring-opening polymerization initiated by decanol (linear), pentaerythritol (4-armed star) and dipentaerythritol (6-armed star), and processed both in the form of films and nanoparticles. Independently on the length or number of their arms, star polymers degrade slower than linear polymers, possibly through a surface (vs...
December 8, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27930841/self-healing-behavior-in-a-thermo-mechanically-responsive-cocrystal-during-a-reversible-phase-transition
#10
Guangfeng Liu, Jie Liu, Xin Ye, Lina Nie, Peiyang Gu, Xutang Tao, Qichun Zhang
The molecular-level motions of a coronene-based supramolecular rotator are amplified into macroscopic changes of crystals by co-assembly of coronene and TCNB (1,2,4,5-tetracyanobenzene) into a charge-transfer complex. The as-prepared cocrystals show remarkable self-healing behavior and thermo-mechanical responses during thermally-induced reversible single-crystal-to-single-crystal (SCSC) phase transitions. Comprehensive analysis of the microscopic observations as well as differential scanning calorimetry (DSC) measurements and crystal habits reveal that a thermally-reduced-rate-dependent dynamic character exists in the phase transition...
December 8, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27929722/medical-attention-seeking-dance-injuries-systematic-review-of-case-reports
#11
Akilesh Anand Prakash
OBJECTIVE: The objective of this study was to conduct a systematic review of case reports documenting the epidemiology of unique and rare musculoskeletal injuries in dancers. STUDY DESIGN: Systematic Review Method: A systematic review was conducted online using PubMed and Google Scholar, as per PRISMA guidelines up to July 30, 2016. Predefined eligibility criteria were applied, and the data thus compiled was analysed. Study quality was assessed based on CARE guidelines...
December 8, 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27929173/novel-mitochondria-targeted-copper-ii-complexes-of-ferrocenyl-terpyridine-and-anticancer-active-8-hydroxyquinolines-showing-remarkable-cytotoxicity-dna-and-protein-binding-affinity
#12
Banashree Deka, Tukki Sarkar, Samya Banerjee, Arun Kumar, Sanjoy Mukherjee, Sasanka Deka, Kandarpa K Saikia, Akhtar Hussain
Metal complexes with organelle specificity and potent but selective cytotoxicity are highly desirable. In this work, we report the synthesis, characterization and cytotoxicity of six novel copper(ii) complexes of the formula [Cu(R-tpy)(N-O)]NO3 (1-6), where R-tpy is 4'-phenyl-2,2':6',2''-terpyridine (Ph-tpy; 1-3) or 4'-ferrocenyl-2,2':6',2''-terpyridine (Fc-tpy; 4-6), N-O is the anion of 8-hydroxyquinoline (HQ in 1, 4), 5-chloro-7-iodo-8-hydroxyquinoline (CQ in 2, 5) or 5-nitro-8-hydroxyquinoline (NQ in 3, 6)...
December 8, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27929104/microneedles-with-controlled-bubble-sizes-and-drug-distributions-for-efficient-transdermal-drug-delivery
#13
Qi Lei Wang, Dan Dan Zhu, Xu Bo Liu, Bo Zhi Chen, Xin Dong Guo
Drug loaded dissolving microneedles (DMNs) fabricated with water soluble polymers have received increasing attentions as a safe and efficient transdermal drug delivery system. Usually, to reach a high drug delivery efficiency, an ideal drug distribution is gathering more drugs in the tip or the top part of DMNs. In this work, we introduce an easy and new method to introduce a bubble with controlled size into the body of DMNs. The introduction of bubbles can prevent the drug diffusion into the whole body of the MNs...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928962/neural-circuits-underlying-fly-larval-locomotion
#14
Hiroshi Kohsaka, Pierre A Guertin, Akinao Nose
Locomotion is a complex motor behavior that may be expressed in different ways using a variety of strategies depending upon species and pathological or environmental conditions. Quadrupedal or bipedal walking, running, swimming, flying and gliding constitute some of the locomotor modes enabling the body, in all cases, to move from one place to another. Despite these apparent differences in modes of locomotion, both vertebrate and invertebrate species share, at least in part, comparable neural control mechanisms for locomotor rhythm and pattern generation and modulation...
December 8, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27928953/novel-hybrid-molecules-on-the-basis-of-steroids-and-5z-9z-tetradeca-5-9-dienoic-acid-synthesis-anti-cancer-studies-and-human-topoisomerase-i-inhibitory-activity
#15
Vladimir A D Yakonov, Lilya U Dzhemileva, Regina A Tuktarova, Svetlana R Ishmukhametova, Milyausha M Yunusbaeva, Ilfir R Ramazanova, Usein M Dzhemilev
Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.
December 7, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27928885/silica-supported-polymeric-monolithic-column-with-a-mixed-mode-of-hydrophilic-and-strong-cation-exchange-interactions-for-microcolumn-liquid-chromatography
#16
Hang Ren, Xinyue Zhang, Zhen Li, Zhaobin Liu, Jinxiang Li
A novel sulfonic acid group containing hydrophilic strong cation-exchange monolith was prepared by in situ coating 5 μm bare silica particles with the copolymers of glycidyl methacrylate and pentaerythritol triacrylate and further sulfonating the prepared polymer matrix with Na2 SO3 inside a 150 μm I.D. capillary. The preparation conditions were investigated and the method was described in detail. The prepared column was characterized by comparing with its counterparts reported previously in terms of matrix morphology, preparation reproducibility, permeability, swelling-shrinking behavior, mechanical stability, hydrophilicity, binding capacity, and column efficiency...
December 8, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27928630/production-and-isolation-of-vanadium-nitrogenase-from-azotobacter-vinelandii-by-molybdenum-depletion
#17
Daniel Sippel, Julia Schlesier, Michael Rohde, Christian Trncik, Laure Decamps, Ivana Djurdjevic, Thomas Spatzal, Susana L A Andrade, Oliver Einsle
The alternative, vanadium-dependent nitrogenase is employed by Azotobacter vinelandii for the fixation of atmospheric N2 under conditions of molybdenum starvation. While overall similar in architecture and functionality to the common Mo-nitrogenase, the V-dependent enzyme exhibits a series of unique features that on one hand are of high interest for biotechnological applications. As its catalytic properties differ from Mo-nitrogenase, it may on the other hand also provide invaluable clues regarding the molecular mechanism of biological nitrogen fixation that remains scarcely understood to date...
December 7, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/27928570/photochemical-and-computational-studies-of-inclusion-complexes-between-%C3%AE-cyclodextrin-and-1-2-dihydroxyanthraquinones
#18
Sonaimuthu Mohandoss, Thambusamy Stalin
The formation of an inclusion complex between 1,2-dihydroxyanthraquinones (1,2-DHAQ) and β-cyclodextrin (β-CD) has been studied by UV-visible, fluorescence spectroscopy and electrochemical methods. The stoichiometric ratio of the inclusion complex was found to be 1 : 1 and the binding constant was evaluated using the Benesi-Hildebrand equation. The peak currents (Ipa and Ipc) change drastically with increasing β-CD concentration and the peak potentials (Epa and Epc) shifted. A mechanism is proposed to explain the inclusion process...
December 8, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27927987/ion-channel-formation-by-amyloid-%C3%AE-42-oligomers-but-not-amyloid-%C3%AE-40-in-cellular-membranes
#19
David C Bode, Mark D Baker, John H Viles
A central hallmark of Alzheimer's disease (AD) is the presence of extracellular amyloid plaques chiefly consisting of amyloid-β (Aβ) peptides in the brain interstitium. Aβ largely exists in two isoforms, 40 or 42 amino acids long, while a large body of evidence points to Aβ(1-42) rather than Aβ(1-40) as the cytotoxic form. One proposed mechanism by which Aβ exerts toxicity is the formation of ion channel pores that disrupt intracellular Ca(2+) homeostasis. However, previous studies using membrane mimetics have not identified any notable difference in the channel-forming properties between Aβ(1-40) and Aβ(1-42)...
December 7, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27927065/aqueous-extract-of-securidaca-longipendunculata-oliv-and-olax-subscropioidea-inhibits-key-enzymes-acetylcholinesterase-and-butyrylcholinesterase-linked-with-alzheimer-s-disease-in-vitro
#20
Jamiu A Saliu, Ayodeji A Olabiyi
CONTEXT: Plants have historically been used to treat neurodegerative diseases which include Alzheimer's disease. OBJECTIVE: This study investigated the antioxidant properties and inhibitory effect of aqueous extracts of Securidaca longipendunculata root and Olax subscropioidea leaf on the cholinergic system in rat brain in vitro. MATERIALS AND METHODS: Aqueous extracts (1:20 w/v) of S. longipendunculata root and O. subscropioidea leaf was prepared and the ability of the extract to inhibit the activities of acetylcholinesterase and butyrylcholinesterase was evaluated as well as antioxidants as typified by 2,2-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid (ABTS(•)) radical scavenging ability and Fe chelation spectophotometrically...
December 2017: Pharmaceutical Biology
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