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https://www.readbyqxmd.com/read/28287431/cytotoxic-natural-products-from-marine-sponge-derived-microorganisms
#1
REVIEW
Huawei Zhang, Ziping Zhao, Hong Wang
A growing body of evidence indicates that marine sponge-derived microbes possess the potential ability to make prolific natural products with therapeutic effects. This review for the first time provides a comprehensive overview of new cytotoxic agents from these marine microbes over the last 62 years from 1955 to 2016, which are assorted into seven types: terpenes, alkaloids, peptides, aromatics, lactones, steroids, and miscellaneous compounds.
March 10, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28282649/emerging-regional-and-racial-disparities-in-the-lifetime-risk-of-human-immunodeficiency-virus-infection-among-men-who-have-sex-with-men-a-comparative-life-table-analysis-in-king-county-wa-and-mississippi
#2
Galant A Chan, Kendra L Johnson, Nicholas G Mosca, Thomas E Dobbs, Julia C Dombrowski, Amy B Bennett, Susan E Buskin, Matthew R Golden
BACKGROUND: Little is known about the lifetime risk of human immunodeficiency virus (HIV) diagnosis among US men who have sex with men (MSM), trends in risk and how risk varies between populations. METHODS: We used census and HIV surveillance data to construct life tables to estimate the cumulative risk of HIV diagnosis among cohorts of MSM born 1940 to 1994 in King County, Washington (KC) and Mississippi (MS). RESULTS: The cumulative risk of HIV diagnosis progressed in 3 phases...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28280344/metabolic-profile-at-first-time-schizophrenia-diagnosis-a-population-based-cross-sectional-study
#3
Henriette Thisted Horsdal, Michael Eriksen Benros, Ole Köhler-Forsberg, Jesper Krogh, Christiane Gasse
OBJECTIVE: Schizophrenia and/or antipsychotic drug use are associated with metabolic abnormalities; however, knowledge regarding metabolic status and physician's monitoring of metabolic status at first schizophrenia diagnosis is sparse. We assessed the prevalence of monitoring for metabolic blood abnormalities and characterized the metabolic profiles in people with a first-time schizophrenia diagnosis. METHODS: This is a population-based cross-sectional study including all adults born in Denmark after January 1, 1955, with their first schizophrenia diagnosis between 2000 and 2012 in the Central Denmark Region...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28271622/a-population-based-study-of-changes-in-arthritis-prevalence-and-arthritis-risk-factors-over-time-generational-differences-and-the-role-of-obesity
#4
Elizabeth M Badley, Mayilee Canizares, Anthony V Perruccio
OBJECTIVES: To investigate cohort effects in arthritis prevalence across four birth cohorts: World War II (born: 1935-1944), older and younger baby boomers (born: 1945-1954 and 1955-1964), and Generation X (born: 1965-1974) and to determine whether birth cohort effects in arthritis prevalence were associated with differences in risk factors over time or period effects. METHODS: Analysis of biannually collected data from the Canadian longitudinal National Population Health Survey 1994-2011 (n= 8817 at baseline)...
March 8, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28264823/changing-trends-in-reproductive-lifestyle-factors-in-uk-women-descriptive-study-within-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#5
Aleksandra Gentry-Maharaj, Clara Glazer, Matthew Burnell, Andy Ryan, Hannah Berry, Jatinderpal Kalsi, Robert Woolas, Steve J Skates, Stuart Campbell, Mahesh Parmar, Ian Jacobs, Usha Menon
OBJECTIVE: There has been considerable interest in the impact of reproductive factors on health but there are little data on how these have varied over time. We explore trends in reproductive/lifestyle factors of postmenopausal British women by analysing self-reported data from participants of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). DESIGN: Prospective birth cohort analysis. SETTING: Population cohort invited between 2001 and 2005 from age-sex registers of 27 Primary Care Trusts in England, Wales and Northern Ireland and recruited through 13 National Health Service Trusts...
March 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28264325/taxonomic-review-of-the-genus-i-atlantodesmus-i-hoffman-2000-polydesmida-chelodesmidae
#6
Rodrigo Salvador Bouzan, João Paulo P Pena-Barbosa, Antonio Domingos Brescovit
The chelodesmid genus Atlantodesmus Hoffman, 2000 is revised and considered a senior synonym of Iemanja Hoffman, 2000. Currently the genus contains five species, all of them are herein redescribed: Atlantodesmus eimeri (Attems, 1898), Atlantodesmus itapurensis (Schubart, 1943), Atlantodesmus pickeli (Schubart, 1946), Atlantodesmus pintoi (Schubart, 1946), and the transferred species from Iemanja, Atlantodesmus teresa (Hoffman, 2000), new combination. The female of Atlantodesmus teresa is described for the first time...
February 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/28259842/is-beryllium-induced-lung-cancer-caused-only-by-soluble-forms-and-high-exposure-levels
#7
Mary K Schubauer-Berigan, James R Couch, James A Deddens
OBJECTIVES: The US Occupational Safety and Health Administration (OSHA) recently proposed a permissible exposure limit of 0.2 µg/m(3) for beryllium, based partly on extrapolated estimates of lung cancer risk from a pooled occupational cohort. The purpose of the present analysis was to evaluate whether cohort members exposed at lower levels to mainly insoluble forms of beryllium exhibit increased risk of lung cancer. METHODS: We conducted Cox proportional hazards regression analyses among 75 lung cancer cases in age-based risk sets within two lower exposure plants in the pooled cohort followed from 1940 to 2005...
March 4, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28255794/military-service-and-crime-new-evidence
#8
David L Snowden, Sehun Oh, Christopher P Salas-Wright, Michael G Vaughn, Erika King
BACKGROUND: Evidence indicates that a substantial proportion of military personnel are involved in high-risk and antisocial behaviors that place them at jeopardy for criminal justice system involvement. However, prior research on military service and crime has disproportionately focused on veterans from the Vietnam War era (1955-1975), and has tended to focus on either current or former military members. METHODS: This study employed data from a population-based study (i...
March 3, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28253375/genomic-and-phenotypic-characterization-of-myxoma-virus-from-great-britain-reveals-multiple-evolutionary-pathways-distinct-from-those-in-australia
#9
Peter J Kerr, Isabella M Cattadori, Matthew B Rogers, Adam Fitch, Adam Geber, June Liu, Derek G Sim, Brian Boag, John-Sebastian Eden, Elodie Ghedin, Andrew F Read, Edward C Holmes
The co-evolution of myxoma virus (MYXV) and the European rabbit occurred independently in Australia and Europe from different progenitor viruses. Although this is the canonical study of the evolution of virulence, whether the genomic and phenotypic outcomes of MYXV evolution in Europe mirror those observed in Australia is unknown. We addressed this question using viruses isolated in the United Kingdom early in the MYXV epizootic (1954-1955) and between 2008-2013. The later UK viruses fell into three distinct lineages indicative of a long period of separation and independent evolution...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28244705/association-of-dietary-vitamin-e-intake-with-risk-of-lung-cancer-a-dose-response-meta-analysis
#10
Yong-Jian Zhu, Ya-Cong Bo, Xin-Xin Liu, Chun-Guang Qiu
BACKGROUND AND OBJECTIVES: Several epidemiological studies investigating the association between dietary vitamin E intake and the risk of lung cancer have demonstrated inconsistent results. Hence, a meta-analysis was conducted to summarise evidence of the association of dietary vitamin E intake with the risk of lung cancer. METHODS AND STUDY DESIGN: In this meta-analysis, a systematic literature search of PubMed and Web of Science was conducted to identify relevant studies published from 1955 to April 2015...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28243842/a-new-putative-alphapartitivirus-recovered-from-the-powdery-mildew-fungus-erysiphe-palczewskii
#11
Guihong Xiong, Ping Qiu, Cong Li, Zhuo Chen, Saif Ul Islam, Shouguo Fang, Zujian Wu, Songbai Zhang, Zhenguo Du
Two double-stranded RNAs (dsRNA) likely representing the genome of a novel alphapartitivirus which we provisionally named Erysiphe palczewskii alphapartitivirus 1 (EpV1) were recovered from the powdery mildew fungus E. palczewskii infecting Sophora japonica in Jingzhou, Hubei province of China. The two dsRNAs, 1955 (dsRNA1) and 1917 (dsRNA2) bp in size, respectively, each contains a single open reading frame (ORF) encoding a 585- and 528-aa protein, respectively. The 585-aa protein contains a conserved RNA-dependent RNA polymerase (RdRp) domain and shows significant homology to RdRps of approved or putative partitiviruses, particularly those belonging to the genus Alphapartitivirus...
February 27, 2017: Virus Genes
https://www.readbyqxmd.com/read/28228842/worldwide-malaria-incidence-and-cancer-mortality-are-inversely-associated
#12
Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong, Xiaoping Chen
BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt's lymphoma (BL) in African children. Our previous murine lung cancer model study demonstrated that malaria infection significantly inhibited tumor growth and prolonged the life span of tumor-bearing mice. This study aims to assess the possible associations between malaria incidence and human cancer mortality. METHODS: We compiled data on worldwide malaria incidence and age-standardized mortality related to 30 types of cancer in 56 countries for the period 1955-2008, and analyzed their longitudinal correlations by a generalized additive mixed model (GAMM), adjusted for a nonlinear year effect and potential confounders such as country's income levels, life expectancies and geographical locations...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28228675/new-species-of-habronattus-and-pellenes-jumping-spiders-araneae-salticidae-harmochirina
#13
Wayne P Maddison
The harmochirine jumping spiders include the New World Habronattus, notable for their complex courtship displays, and Pellenes, found throughout the Old World and North America. Five new species of Habronattus and one new species of Pellenes are here described from North America: Habronattus aestus, sp. n., Habronattus chamelasp. n., Habronattus empyrussp. n., Habronattus luminosussp. n., Habronattus robertisp. n., and Pellenes canadensissp. n. For each of the new species, photographs of living specimens are given, as well as notes on habitat...
2017: ZooKeys
https://www.readbyqxmd.com/read/28222727/developing-global-maps-of-insecticide-resistance-risk-to-improve-vector-control
#14
Michael Coleman, Janet Hemingway, Katherine Ann Gleave, Antoinette Wiebe, Peter W Gething, Catherine L Moyes
BACKGROUND: Significant reductions in malaria transmission have been achieved over the last 15 years with elimination occurring in a small number of countries, however, increasing drug and insecticide resistance threatens these gains. Insecticide resistance has decreased the observed mortality to the most commonly used insecticide class, the pyrethroids, and the number of alternative classes approved for use in public health is limited. Disease prevention and elimination relies on operational control of Anopheles malaria vectors, which requires the deployment of effective insecticides...
February 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28212303/associations-of-overweight-obesity-and-related-factors-with-sleep-related-breathing-disorders-and-snoring-in-adolescents-a-cross-sectional-survey
#15
Yue Ma, Liping Peng, Changgui Kou, Shucheng Hua, Haibo Yuan
Background: Sleep-related breathing disorders (SRBD) have been identified as a major public health problem closely related to adolescent obesity. We aimed to estimate the prevalences of SRBD and snoring in adolescents in Changchun City, Northeastern China, and to evaluate the associated factors in this population. Methods: In total, 1955 adolescents aged 11-18 years were recruited in Changchun City using stratified cluster sampling. Parents and caretakers of children completed the questionnaires, which included demographic characteristics, anthropometric parameters and a pediatric sleep questionnaire (SRBD scale)...
February 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28209409/interplay-between-river-dynamics-and-international-borders-the-hirmand-river-between-iran-and-afghanistan
#16
Saleh Yousefi, Saskia Keesstra, Hamid Reza Pourghasemi, Nicola Surian, Somayeh Mirzaee
Fluvial dynamics in riverine borders can play an important role in political relationships between countries. Rivers move and evolve under the influence of natural processes and external drivers (e.g. land use change in river catchments). The Hirmand River is an important riverine border between Iran and Afghanistan. The present study shows the evolution and lateral shifting of the Hirmand River along the international border (25.6km) over a period of 6 decades (1955-2015). Seven data series of aerial photos, topographic maps and Landsat images were used to analyze land cover and channel changes in the study reach...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28199894/height-and-blood-chemistry-in-adults-with-a-history-of-developmental-arsenic-poisoning-from-contaminated-milk-powder
#17
Takashi Yorifuji, Kenichi Matsuoka, Philippe Grandjean
BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955. OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later...
February 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28196502/regional-variation-in-suicide-rates-in-sri-lanka-between-1955-and-2011-a-spatial-and-temporal-analysis
#18
Duleeka W Knipe, Prianka Padmanathan, Lal Muthuwatta, Chris Metcalfe, David Gunnell
BACKGROUND: Between 1955 and 2011 there were marked fluctuations in suicide rates in Sri Lanka; incidence increased six-fold between 1955 and the 1980s, and halved in the early 21st century. Changes in access to highly toxic pesticides are thought to have influenced this pattern. This study investigates variation in suicide rates across Sri Lanka's 25 districts between 1955 and 2011. We hypothesised that changes in the incidence of suicide would be most marked in rural areas due to the variation in availability of highly toxic pesticides in these locations during this time period...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28192643/associations-between-substance-use-disorders-and-suicide-or-suicide-attempts-in-people-with-mental-illness-a-danish-nationwide-prospective-register-based-study-of-patients-diagnosed-with-schizophrenia-bipolar-disorder-unipolar-depression-or-personality-disorder
#19
Marie L D Østergaard, Merete Nordentoft, Carsten Hjorthøj
AIM: To estimate and test associations between substance use disorders (SUDs) and both completed suicides and suicide attempts in a population with severe mental illness. DESIGN: Register-based cohort study with adjusted Cox regression of substance use disorders as time-varying covariates. SETTING: Denmark. PARTICIPANTS: People born in Denmark since 1955 with a diagnosis of schizophrenia (n = 35,625), bipolar disorder (n = 9,279), depression (n = 72,530), or personality disorder (n = 63,958)...
February 13, 2017: Addiction
https://www.readbyqxmd.com/read/28192118/prg4-expression-in-myxoid-liposarcoma-maintains-tumor-cell-growth-through-suppression-of-an-antitumor-cytokine-il-24
#20
Kosuke Oikawa, Anna Mizusaki, Masakatsu Takanashi, Takashi Ozaki, Fuyuki Sato, Masahiko Kuroda, Yasuteru Muragaki
PRG4 is one of the downstream molecules of the myxoid liposarcoma (MLS)-specific fusion oncoproteins TLS-CHOP and EWS-CHOP. Exogenous PRG4 expression increases the tumorigenicity of cells injected in nude mice. The molecular functions of PRG4 in tumorigenesis and/or tumor progression of MLS cells, however, still remain unclear. In this report, we demonstrated that siRNA-mediated knockdown of PRG4 suppressed the growth of the MLS-derived cell lines 1955/91 and 2645/94. In addition, PRG4 knockdown promoted adipocytic differentiation in 1955/91 cells...
March 25, 2017: Biochemical and Biophysical Research Communications
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