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GERD and women

Kirsten Lerum Indrebø, Gerd Karin Natvig, John Roger Andersen
Ostomy-specific adjustment may or may not predict health-related quality of life (HRQoL) and/or overall quality of life (QoL). A cross-sectional study was conducted among patients recruited from the customer registers of 8 surgical suppliers and pharmacies across Norway between November 2010 and March 2011 to determine which of the 34 items of the Ostomy Adjustment Scale (OAS) are the strongest predictors for HRQoL and overall QoL and to determine the HRQoL and overall QoL of individuals with an ostomy compared to a control group representing the general population...
October 2016: Ostomy/wound Management
Veronika Günther, Ibrahim Alkatout, Corinna Fuhs, Ali Salmassi, Liselotte Mettler, Jürgen Hedderich, Nicolai Maass, Mohamed Elessawy, Andreas Gerd Schmutzler, Christel Eckmann-Scholz
Cytokines are key modulators of the immune system and play an important role in the ovarian cycle. IL-18 levels in serum and follicular fluid were analyzed in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. The cohort study group consisted of 90 women, who were undergoing IVF or ICSI. The body mass index (BMI) was determined in all patients; IL-18 levels were measured in follicular fluid and serum. IL-18 levels in serum were significantly higher than those in follicular fluid...
2016: BioMed Research International
N Gerdes, E Farin
Objective: Taking Fibromyalgia syndrome (FMS) as an example, the article illustrates a problem that to our knowledge has not been addressed in rehabilitation research so far: According to our large dataset, a sizeable proportion of patients had to be sent home with extremely severe burdens (<2(nd) percentile in the normal population) at discharge - in spite of good improvements during their stay. Data and methods: Since 2009, patients in the RehaKlinikum Bad Säckingen, an in-patient rehab center for orthopedic-rheumatic diseases, answer the questionnaire "Indicators of Rehabilitation Status" (IRES) at the beginning and the end of their stay...
October 2016: Die Rehabilitation
Young Sun Kim, Nayoung Kim, Gwang Ha Kim
It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as reflux esophagitis, Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) more frequently than women. The prevalence of reflux esophagitis is significantly increased with age in women, especially after their 50s...
October 30, 2016: Journal of Neurogastroenterology and Motility
Mark W Cunningham, Jan M Williams, Lorena Amaral, Nathan Usry, Gerd Wallukat, Ralf Dechend, Babbette LaMarca
Preeclamptic women produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) and exhibit increased blood pressure (mean arterial pressure), vascular sensitivity to angiotensin II (ANG II), and display a decrease in renal function. The objective of this study was to examine the renal hemodynamic changes during pregnancy in the presence of AT1-AAs with or without a slow pressor dose of ANG II. In this study, mean arterial pressure was elevated in all pregnant rats treated with ANG II with or without AT1-AA...
November 2016: Hypertension
S D Pointer, J Rickstrew, J C Slaughter, M F Vaezi, H J Silver
BACKGROUND: Although obesity rates are higher in African-American than European-American women, gastro-oesophageal reflux disease (GERD) and its comorbidities are more prevalent in European-American women. A common denominator for increased adiposity, and consequent insulin resistance, is excess dietary macronutrient intake - which may promote greater prevalence and severity of GERD in women. AIM: To investigate whether GERD is more robustly associated with dietary carbohydrate intake, particularly dietary simple carbohydrate intake, and insulin resistance in European-American women...
November 2016: Alimentary Pharmacology & Therapeutics
Anoop Prabhu, Kenneth Obi, David Lieberman, Joel H Rubenstein
OBJECTIVES: The relative impact of esophageal squamous cell carcinoma (ESCC) in minority populations is incompletely understood. We aimed to estimate the race-specific incidences of ESCC and place these in the context of the incidence of esophageal adenocarcinoma (EAC) in white men with gastroesophageal reflux disease (GERD). METHODS: The race- and sex-specific exposures to tobacco and alcohol in the United States were obtained from the National Health Interview Survey...
August 30, 2016: American Journal of Gastroenterology
Brian M Lin, Sharon G Curhan, Molin Wang, Brian C Jacobson, Roland Eavey, Konstantina M Stankovic, Gary C Curhan
OBJECTIVES: Gastroesophageal reflux disease (GERD) is common and often treated with proton pump inhibitors (PPIs) or H2-receptor antagonists (H2-RAs). GERD has been associated with exposure of the middle ear to gastric contents, which could cause hearing loss. Treatment of GERD with PPIs and H2-RAs may decrease exposure of the middle ear to gastric acid and decrease the risk of hearing loss. We prospectively investigated the relation between GERD, use of PPIs and H2-RAs, and the risk of hearing loss in 54,883 women in Nurses' Health Study II...
August 22, 2016: Ear and Hearing
Verónica Gorodner, Rudolf Buxhoeveden, Gastón Clemente, Christian Sánchez, Luis Caro, Alejandro Grigaites
INTRODUCTION: Barrett's esophagus (BE) is recognized as a premalignant lesion for esophageal adenocarcinoma. BE appears as a consequence of gastroesophageal reflux disease (GERD), which is increased among obese population. Laparoscopic Roux-en-Y gastric bypass (LRYGB) is the best treatment option for obesity combined with GERD. However, data on evolution of BE after LRYGB are scarce. METHODS AND PROCEDURES: Patients were studied with esophagogastroduodenoscopy (EGD) and gastric biopsy preoperatively...
August 23, 2016: Surgical Endoscopy
Jeroen S de Munter, Per Tynelius, Gerd Ahlström, Finn Rasmussen
BACKGROUND: Obesity is more common in people with mobility disability than in non-disabled individuals, but less is known about the longitudinal effects leading to this health state. OBJECTIVE: To explore the potential bidirectional association between mobility disability and obesity. METHODS: Participants were identified in the population-based Stockholm Public Health Cohort (2002-2010, n = 17 945). Observations with schizophrenia, depression, eating disorder, or cancer within 5 years during and prior to baseline were excluded...
October 2016: Disability and Health Journal
Rachel S Gruver, Chanelle T Bishop-Gilyard, Alexandra Lieberman, Marsha Gerdes, Senbagam Virudachalam, Andrew W Suh, Gurpreet K Kalra, Sheela N Magge, Justine Shults, Mark S Schreiner, Thomas J Power, Robert I Berkowitz, Alexander G Fiks
BACKGROUND: Evidence increasingly indicates that childhood obesity prevention efforts should begin as early as infancy. However, few interventions meet the needs of families whose infants are at increased obesity risk due to factors including income and maternal body mass index (BMI). Social media peer groups may offer a promising new way to provide these families with the knowledge, strategies, and support they need to adopt obesity prevention behaviors. OBJECTIVE: The aim of this study is to develop and pilot test a Facebook-based peer group intervention for mothers, designed to prevent pediatric obesity and promote health beginning in infancy...
2016: JMIR Research Protocols
Mathilde Gottschau, Lene Mellemkjaer, Charlotte G Hannibal, Susanne K Kjaer
INTRODUCTION: The Nordic countries are areas with a high-incidence of ovarian cancer; however, differences between the countries exist. MATERIAL AND METHODS: We used the Danish Cancer Registry to identify 11 264 cases of ovarian cancer and 363 cases of tubal cancer during 1993-2013. We calculated age-standardized (world standard population) incidence rates for overall and subtype-specific ovarian cancer, and for tubal cancer. We compared age-standardized incidence rates, and 1- and 5-year age-standardized relative survival rates, respectively, for ovarian and tubal cancer combined in four Nordic countries using the NORDCAN database...
October 2016: Acta Obstetricia et Gynecologica Scandinavica
Maria Gudrun Biersack, Malgorzata Hajdukiewicz, Ralf Uebelhack, Leonora Franke, Helmut Piazena, Pascal Klaus, Vera Höhne-Zimmer, Tanja Braun, Frank Buttgereit, Gerd-Rüdiger Burmester, Jacqueline Detert
OBJECTIVES: Vitamin D (VitD) deficiency is a health problem prevalent not only in the elderly but also in young adults. The primary objective of our observational pilot study "MUVY" (Mood, UVR, Vitamin D in Young women) was to test both the short-term and long-term effects of a series of three suberythemal UV radiation (UVR) exposures on the VitD status and well-being of young healthy women during winter in a repeat measure design. METHODS: 20 healthy young women (Fitzpatrick skin types I-III, aged 21-25 years) received three full body broad band UVR exposures with an escalating erythemally weighted dose schedule during one week in winter, and completed self-report questionnaires monitoring symptoms of depression (Beck Depression Inventory, BDI) and affective state/well-being (Profile of Mood States, POMS) at baseline and three days after the last UVR exposure...
2016: PloS One
Jieying Jiang, Nikolina Icitovic, Michael A Crane, Christopher R Dasaro, Julia R Kaplan, Roberto G Lucchini, Benjamin J Luft, Jacqueline M Moline, Lakshmi Pendem, Moshe Shapiro, Iris G Udasin, Andrew C Todd, Susan L Teitelbaum
BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively. METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015. RESULTS: The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men...
September 2016: American Journal of Industrial Medicine
Jacqueline Detert, René Dziurla, Paula Hoff, Timo Gaber, Pascal Klaus, Hans Bastian, Tanja Braun, Saskia Schellmann, Thomas Penzel, Ingo Fietze, Peter-Andreas Loeschmann, Peter Jaehnig, Rainer H Straub, Gerd R Burmester, Frank Buttgereit
OBJECTIVES: To compare sleep quality, disease activity and patient-reported outcomes such as fatigue and immune parameters in patients with rheumatoid arthritis treated with etanercept (ETA) or methotrexate (MTX). METHODS: Of 36 patients (28-joint Disease Activity Score, DAS28CRP≥3.2) in this 16-week (w), open, prospective study, 19 (11 women) received MTX 12.5-17 mg/w, and 17 (14 women) received ETA 25 mg x 2/w, alone or in combination with MTX. Clinical (DAS28CRP, visual analogue scale), laboratory (C-reactive protein [CRP]), sleep (polysomnography), functional (Multidimensional Fatigue Inventory; Health Assessment Questionnaire-Disability Index (HAQ-DI); 36-item Short-Form Health Survey (SF-36), immunological (humoral/cellular) and neuroendocrine (hormonal) parameters were recorded at baseline (BL), w8 and w16...
June 22, 2016: Clinical and Experimental Rheumatology
Maria Pina Dore, Giovanni Mario Pes, Gabrio Bassotti, Maria Antonietta Farina, Giuseppina Marras, David Yates Graham
OBJECTIVE: Gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma have been increasing. We studied the relationship of conventional risk factors and Helicobacter pylori infection in patients with erosive and non-erosive GERD and Barrett's esophagus. MATERIALS AND METHODS: This was a retrospective study of dyspeptic patients undergoing upper endoscopy between 2002 and 2013. Following endoscopy, those with previously undiagnosed GERD were sub-grouped into non-erosive GERD (NERD), erosive GERD (eGERD), or Barrett's esophagus...
November 2016: Scandinavian Journal of Gastroenterology
Gerd Glaeske
Over the past few years, perceptible changes - both fundamental and specific - have taken place in pharmaceutical care for men. While the most striking difference persists, namely that between somatic drug therapies for men and drugs for the treatment of psychological disorders and diseases, the large discrepancies that long existed between the quantities prescribed for men and women have meanwhile not only evened out, but men are even prescribed larger quantities than women if they undergo drug therapy. An analysis of the drugs prescribed particularly for men revealed that they are primarily prescribed for the treatment of cardiovascular diseases (hypertension and cardiac insufficiency) and metabolic disorders (diabetes, gout), especially in elderly patients...
August 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Gerd R Burmester, Robert Landewé, Mark C Genovese, Alan W Friedman, Nathan D Pfeifer, Nupun A Varothai, Ana P Lacerda
BACKGROUND: Adalimumab has been used in patients with moderately to severely active rheumatoid arthritis (RA) for over 10 years and has a well-established safety profile across multiple indications. OBJECTIVE: To update adverse events (AEs) of special interest from global adalimumab clinical trials in patients with RA. METHODS: This analysis includes 15 132 patients exposed to adalimumab in global RA clinical trials. AEs of interest included overall infections, laboratory abnormalities and AEs associated with influenza vaccination...
June 23, 2016: Annals of the Rheumatic Diseases
Bradley J Kendall, Joel H Rubenstein, Michael B Cook, Thomas L Vaughan, Lesley A Anderson, Liam J Murray, Nicholas J Shaheen, Douglas A Corley, Apoorva K Chandar, Li Li, Katarina B Greer, Amitabh Chak, Hashem B El-Serag, David C Whiteman, Aaron P Thrift
BACKGROUND & AIMS: Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. METHODS: We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium...
October 2016: Clinical Gastroenterology and Hepatology
Laure Luciano, Brigitte Granel, Emmanuelle Bernit, Jean-Robert Harle, Karine Baumstarck, Jean-Charles Grimaud, Michel Bouvier, Véronique Vitton
OBJECTIVES: In systemic sclerosis (SSc), esophageal and anorectal involvements are frequent and often associated with each other. In clinical practice, esophageal explorations are often prescribed, while anorectal explorations are rarely proposed and therefore, under-recognised. However, it is well documented in the literature that early detection of anorectal dysfunction could delay and/or prevent the onset of symptoms such as fecal incontinence (FI). The main objective was the systematic evaluation and detection of esophageal and anorectal involvements in SSc patients...
May 24, 2016: Clinical and Experimental Rheumatology
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