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Nahla S El-Shenawy, Reham Z Hamza, Howayda E Khaled
The α-lipoic acid is a soft material and useful for the potential biomedical applications. The study was aimed to assess the potency of α-lipoic acid (ALA) against the toxicity of dimethylnitrosamine (DMN) on spleen of mice by assessing the antioxidants, histopathological and ultrastructure changes. The experiment was achieved on six groups of male mice as following; groups 1, 2, 3, and 4 were served as a control, ALA groups, low dose of DMN (DMN-LD; 2mgkg(-1)) and high dose of DMN (DMN-HD; 4mgkg(-1)). Group 5 was received DMN-LD plus ALA and group 6 was given DMN-HD plus ALA...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tianqian Hui, Peng A, Yuan Zhao, Jing Yang, Ling Ye, Chenglin Wang
OBJECTIVE: Pulpitis is a multi-factorial disease that could be caused by complex interactions between genetics, epigenetics and environmental factors. We aimed to evaluate the role of Enhancer of Zeste Homolog 2 (EZH2) in the inflammatory response of human dental pulp cells (HDPCs) and dental pulp tissues. METHODS: The expressions of inflammatory cytokines in HDPCs treated by EZH2 complex or EZH2 siRNA with or without rhTNF-α were examined by quantitative real-time polymerase chain reaction (q-PCR)...
October 7, 2017: Archives of Oral Biology
Anil Kumar, Harvinder Singh Saini, Sudhir Kumar
Indigenous bacterial strain Pseudomonas balearica SAE1, tolerant to e-waste toxicity was isolated from an e-waste recycling facility Exigo Recycling Pvt. Ltd., India. Toxicity tolerance of bacterial strain was analyzed using crushed (particle size ≤150 µm) waste computer printed circuit boards (PCBs)/liter (L) of culture medium. The EC50 value for SAE1 was 325.7 g/L of the e-waste pulp density. Two-step bioleaching was then applied to achieve the dissolution of gold (Au) and silver (Ag) from the e-waste...
October 13, 2017: Current Microbiology
Roula Berbari, Hussein Fayyad-Kazan, Mohamad Ezzedine, Mohammad Fayyad-Kazan, Daniel Bandon, Elia Sfeir
AIMS AND OBJECTIVES: The aim of this study was to assess the correlation between the remaining dentin thickness (RDT) in deep decayed primary molars and the inflammatory status and bacterial composition of the corresponding coronal pulp. We hypothesized that RDT could be used as a reference for clinicians in assigning the indication for pulpotomy. MATERIALS AND METHODS: Pulpotomies were conducted on the cameral pulp of 48 primary molars. Microorganisms, such as Lactobacillus sp...
September 2017: Journal of International Society of Preventive & Community Dentistry
Takeharu Wada, Kei Iwasaki, Yasushi Minobe, Mitsuhiro Wada, Shigeo Imai, Satoko Ishii
To determine the amounts and chemical forms of chlorine compounds in elemental chlorine-free (ECF) bleached pulp for sanitary products, a chemical-form-based quantitative analysis flow scheme was created. The scheme involves quantitative determination of compounds eluted in elution tests assuming dermal exposure. The results indicated that most of the chlorine compounds in pulp used for sanitary products were insoluble organically bound chlorine and water-soluble chlorides consisting of chloride ions. The total amount of chlorine obtained by analysis of the total chlorine in the pulp products was close to the sum of the amounts of water-soluble chlorides, residual chlorine, chloroacetic acids, and insoluble organically bound chlorine...
October 9, 2017: Regulatory Toxicology and Pharmacology: RTP
H M A Ahmed, P M H Dummer
Understanding the normal anatomical features as well as the more unusual developmental anomalies of teeth, roots and root canals is essential for successful root canal treatment. In addition to various types of root canal configuration and accessory canal morphology, a wide range of developmental tooth, root and canal anomalies exist, including C-shaped canals, dens invaginatus, taurodontism, root fusion, dilacerations, palato-gingival grooves. There is a direct association between developmental anomalies and pulp and periradicular diseases that usually requires a multidisciplinary treatment approach to achieve a successful outcome...
October 12, 2017: International Endodontic Journal
Renata Oliveira Samuel, João Eduardo Gomes-Filho, Mariane Maffei Azuma, Dóris Hissako Sumida, Sandra Helena Penha de Oliveira, Fernando Yamamoto Chiba, Suely Regina Mogami Bomfim, Paulo César Ciarlini, Luis Gustavo Narciso, Luciano Tavares Angelo Cintra
OBJECTIVES: The aim of this study was to determine whether the presence of single or multiple apical periodontitis (AP) alters blood cell counts and cytokine production. MATERIAL AND METHODS: Thirty rats were divided into three groups: a control group comprising rats without AP, a group called 1AP comprising rats with AP in one tooth, and a group called 4AP comprising rats with AP in four teeth. Endodontic infection was induced by pulp exposure of the first right maxillary molar in the 1AP group or by exposing the first and second right maxillary and mandibular molars in the 4AP group...
October 11, 2017: Clinical Oral Investigations
Petra Hilkens, Annelies Bronckaers, Jessica Ratajczak, Pascal Gervois, Esther Wolfs, Ivo Lambrichts
Adequate vascularization, a restricting factor for the survival of engineered tissues, is often promoted by the addition of stem cells or the appropriate angiogenic growth factors. In this study, human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAPs) were applied in an in vivo model of dental pulp regeneration in order to compare their regenerative potential and confirm their previously demonstrated paracrine angiogenic properties. 3D-printed hydroxyapatite scaffolds containing DPSCs and/or SCAPs were subcutaneously transplanted into immunocompromised mice...
2017: Stem Cells International
Duangporn Duangthip, Kitty Jieyi Chen, Sherry Shiqian Gao, Edward Chin Man Lo, Chun Hung Chu
Early childhood caries (ECC) is a significant global health problem affecting millions of preschool children worldwide. In general, preschool children from families with 20% of the lowest family incomes suffered about 80% of the ECC. Most, if not all, surveys indicated that the great majority of ECC was left untreated. Untreated caries progresses into the dental pulp, causing pain and infection. It can spread systemically, affecting a child's growth, development and general health. Fundamental caries management is based on the conventional restorative approach...
October 10, 2017: International Journal of Environmental Research and Public Health
Alexandra M Montoya, Carolina E Luna-Rodríguez, Rogelio de J Treviño-Rangel, Miguel Becerril-García, Raquel G Ballesteros-Elizondo, Odila Saucedo-Cárdenas, Gloria M González
Trichosporon asahii is an opportunistic yeastlike fungus that colonizes the gastrointestinal and respiratory tracts and human skin. Although it is an important cause of disseminated infections by non-Candida species, there are a few reports related to its virulence factors and their possible role in in vivo pathogenicity. We developed a murine model of disseminated trichosporonosis in immunocompetent mice for the evaluation of the in vivo pathogenicity of 6 T. asahii isolates with different in vitro virulence factor profiles...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Cecily A Flemming, Vince Pileggi, Shu Chen, Susan S Lee
Regulatory policies to manage land application of organic materials are risk based, with focus on the quality of these residuals. The Ontario Ministry of the Environment and Climate Change (MOECC) determined that limited information was available on pulp and paper biosolids (PPB) with respect to human enteric pathogens. To address this data gap, MOECC conducted an extensive survey (2005-2006) across Ontario to characterize the microbiological quality of PPB. Quantitative testing was performed for fecal indicators (, enterococci, ) and enteric pathogens (, , , and ) using matrix-validated methods...
September 2017: Journal of Environmental Quality
Ayse Gulsahi, Cemal Kivanc Kulah, Bahadir Bakirarar, Orhan Gulen, Kivanc Kamburoglu
OBJECTIVES: After tooth eruption, the size of the pulp cavity decreases with age due to deposition of secondary dentine. The aim of this study was to invastigate the relation between the Chronological age(CA) and the ratio of pulp volume (PV) to tooth volume (TV) measurements using cone-beam computed tomography (CBCT) images of single rooted teeth. METHODS: Maxillary anterior, canine and mandibular canine/premolar CBCT scans of patients older than 15 years of age were collected from the archives between 2013-2015 years...
October 9, 2017: Dento Maxillo Facial Radiology
Wenjie Zhang, Guangzheng Yang, Xiansong Wang, Liting Jiang, Fei Jiang, Guanglong Li, Zhiyuan Zhang, Xinquan Jiang
The scaffold-free cell-sheet technique plays a significant role in stem-cell-based regeneration. Furthermore, growth factors are known to direct stem cell differentiation and enhance tissue regeneration. However, the absence of an effective means to incorporate growth factors into the cell sheets hinders further optimization of the regeneration efficiency. Here, a novel design of magnetically controlled "growth-factor-immobilized cell sheets" is reported. A new Fe3 O4 magnetic nanoparticle (MNP) coated with nanoscale graphene oxide (nGO@Fe3 O4 ) is developed to label stem cells and deliver growth factors...
October 9, 2017: Advanced Materials
Juan Manuel Villa-Hernández, Gabriela Mendoza-Cardoso, José Alberto Mendoza-Espinoza, Cristián Vela-Hinojosa, Fernando Díaz de León-Sánchez, Fernando Rivera-Cabrera, Irán Alia-Tejacal, Laura J Pérez-Flores
Spondias purpurea L. is a fruit native to Mexico, however, it is found as far away as Brazil. It possesses a high commercial potential owing to its sensorial and nutritional qualities and its low cost of production. There exists a variety of ecotypes that have not been characterized and their adequate selection process, according to their strongest functional characteristics, will allow the establishment of improvement programs for this genetic resource. The object of this study was the chemical characterization and the determination of the in vitro and in vivo antioxidant capacity of 7 Spondias purpurea L...
October 9, 2017: Journal of Food Science
Yousra Akhlef, Ole Schwartz, Jens O Andreasen, Simon Storgård Jensen
Tooth replacement in the anterior maxilla is most often indicated after traumatic dental injury or due to congenital missing teeth. Treatment alternatives include implant-supported restorations, conventional fixed bridges, acid-etched bridges, orthodontic space closure, or autotransplantation. Dental implants have gained increased popularity over the last 40 years. However, this treatment modality is contraindicated in patients with continuous growth of the alveolar process due to the risk of severe infrapostion of the dental implant...
October 9, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Fei Wang, Jing Zuo, Yueheng Li, Zhengyan Yang, Jun Luo
To explore the effect of low intensity pulsed ultrasound (LIPUS) on TGF-β1/Smad 2, 3 signal pathway during the dentin injury and repair.
 Methods: Among 25 Sprague-Dawley rats, 5 rats served as a blank control group without treatment. The remaining 20 rats received modified caries preparation inbilateral maxillary first molars to establish a model of dentin-pulp injury and repair. The right maxillary first molars served as a LIPUS group, which received LIPUS irradiation (frequency: 1.5 MHz, pulse width: 200 μs, pulse repetition frequency: 1 kHz, spatial averaged temporal averaged intensity: 30 mW/cm2, 20 min/d), and the left maxillary first molars served as a cavity-prepared group, which received fake LIPUS irradiation...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Shota Murayama, Kiyofumi Yamamoto, Mari Kaneko, Bunnai Ogiso, Masayuki Kobayashi
The primary sensory cortex exhibits neuroplastic changes responding to sensory disturbances, and GABAergic synaptic transmission plays a critical role in the regulation of plasticity. The insular cortex (IC) integrates orofacial nociceptive signals conveyed via myelinated Aδ- and unmyelinated C-fibers. However, it has been unknown whether a disturbance of nociceptive inputs, such as a deletion of the peripheral nerves, alters GABAergic local circuit in IC. The present study elucidated GABAergic synaptic transmission in the model rat whose C-fibers were ablated by capsaicin injection 1-2 days after birth...
October 5, 2017: Neuroscience
A Francisco, S P Alves, P V Portugal, M T Dentinho, E Jerónimo, S Sengo, J Almeida, M C Bressan, V M R Pires, C M Alfaia, J A M Prates, R J B Bessa, J Santos-Silva
Meat from lambs finished with high-starch diets often contains low concentration of vaccenic (t11-18:1) and rumenic (c9,t11-18:2) acids and high concentration of t10-18:1. We hypothesized that replacing cereals by dehydrated citrus pulp (DCP) and the inclusion of tanniferous feed sources in oil supplemented diets might reduce the accumulation of t10-18:1 and increase the t11-18:1 and c9,t11-18:2 in lamb meat, without affecting the productive performance. In total, 32 lambs were assigned to four diets which combine two factors: basal diet (BD) (cereals v...
October 9, 2017: Animal: An International Journal of Animal Bioscience
M Maltz, B Koppe, J J Jardim, L S Alves, L M de Paula, P M Yamaguti, J C F Almeida, M S Moura, H D Mestrinho
OBJECTIVE: This multicenter randomized controlled clinical trial aimed to compare the outcomes of stepwise excavation (SW) and partial caries removal (PCR) regarding the maintenance of pulp vitality in deep caries lesions over 5 years. METHODS: At baseline, 299 permanent molars with deep caries lesions were randomly assigned to control or test groups. The control group received the stepwise excavation treatment (SW), while the test group received partial caries removal from the pulpal wall followed by restoration in a single session (PCR)...
October 8, 2017: Clinical Oral Investigations
Meriem Jouini, Amal Abdelhamid, Mohamed Aymen Chaouch, Didier le Cerf, Abderrahman Bouraoui, Hatem Majdoub, Hichem Ben Jannet
The aim of this study is to isolate pectin from peel (WNPE) and pulp (WNPU) of Opuntia microdasys var. rufida's (OMR) cladodes and to characterize these polysaccharides by size exclusion (SEC/MALS/VD/DRI), gas chromatography coupled to mass spectrometer (GC-MS), nuclear magnetic resonance ((1)H NMR), and Fourier transform infrared spectroscopy (FTIR) analysis. The polysaccharides were extracted in neutral aqueous media followed by ethanol precipitation and dialysis. Both WNPE and WNPU are mainly composed of uronic acids and some neutral sugars such as arabinose, galactose, rhamnose and mannose...
October 4, 2017: International Journal of Biological Macromolecules
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