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https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#1
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27170434/vitamin-d-deficiency-and-pregnancy-rates-following-frozen-thawed-embryo-transfer-a-prospective-cohort-study
#2
Arne van de Vijver, Panagiotis Drakopoulos, Lisbet Van Landuyt, Alberto Vaiarelli, Christophe Blockeel, Samuel Santos-Ribeiro, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: What is the effect of vitamin D deficiency on the pregnancy rates following frozen embryo transfer (FET)?. SUMMARY ANSWER: Vitamin D deficiency does not affect pregnancy rates in FET cycles. WHAT IS KNOWN ALREADY: Although there is evidence that the potential impact of vitamin D deficiency on reproductive outcome may be mediated through a detrimental effect on oocyte or embryo quality, the rationale of our design was based on evidence derived from basic science, suggesting that vitamin D may have a key role in endometrial receptivity and implantation...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27034455/the-diabetes-telephone-study-design-and-challenges-of-a-pragmatic-cluster-randomized-trial-to-improve-diabetic-peripheral-neuropathy-treatment
#3
Alyce S Adams, Elizabeth A Bayliss, Julie A Schmittdiel, Andrea Altschuler, Wendy Dyer, Romain Neugebauer, Marc Jaffe, Joseph D Young, Eileen Kim, Richard W Grant
BACKGROUND: Challenges to effective pharmacologic management of symptomatic diabetic peripheral neuropathy include the limited effectiveness of available medicines, frequent side effects, and the need for ongoing symptom assessment and treatment titration for maximal effectiveness. We present here the rationale and implementation challenges of the Diabetes Telephone Study, a randomized trial designed to improve medication treatment, titration, and quality of life among patients with symptomatic diabetic peripheral neuropathy...
June 2016: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/26416135/race-related-healthcare-disparities-among-california-workers-public-health-considerations-for-immigration-reform
#4
Christopher Eric McCoy, Randy Woo, Craig Anderson, Shahram Lotfipour
BACKGROUND: Healthcare disparities are prevalent in medicine and identifying them will provide healthcare professionals, administrators, and policy makers needed information to address this public health concern. OBJECTIVE: To evaluate racial and ethnic disparities in the rates of hospital admission and death among California workers. METHODS: We performed an analysis of hospital and emergency department (ED) data from the Office of Statewide Health Planning and Development (OSHPD)...
January 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26312251/provision-of-pharmaceutical-care-in-patients-with-limited-english-proficiency-preliminary-findings
#5
Devinder Singh Arora, Amary Mey, Satish Maganlal, Sohil Khan
OBJECTIVE: Overcoming language and cultural barriers is becoming ever challenging for pharmacists as the patient population grows more ethnically diverse. To evaluate the current practices used by the pharmacists for communicating with patients with limited English proficiency (LEP) and to assess pharmacists' knowledge of, attitude toward, and satisfaction with accessing available services for supporting LEPs patients within their current practice settings. METHODS: Semi-structured interviews were conducted with five pharmacists employed in pharmacies representing multiple practice settings Queensland, Australia...
July 2015: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/26225677/association-of-knowledge-and-cultural-perceptions-of-malaysian-women-with-delay-in-diagnosis-and-treatment-of-breast-cancer-a-systematic-review
#6
REVIEW
Tahir Mehmood Khan, Jamie Pik Yan Leong, Long Chiau Ming, Amer Hayat Khan
BACKGROUND: Breast cancer is the most common cancer and the leading cause of cancer mortality among women of all ethnic and age groups in Malaysia. Delay in seeking help for breast cancer symptoms is preventable and by identifying possible factors for delayed diagnosis, patient prognosis and survival rates could be improved. OBJECTIVES: This narrative review aimed to understand and evaluate the level of in-depth breast cancer knowledge in terms of clinical breast examination and breast self-examination, and other important aspects such as side-effects and risk factors in Malaysian females...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26186248/personalized-medicine-in-sarcoidosis-predict-responders-and-nonresponders
#7
REVIEW
Martin Petrek
PURPOSE OF REVIEW: Treatment of sarcoidosis, a granulomatous disease affecting multiple organs with predominance to the lung, is complicated by variable response of individual patients to treatment options ranging from corticosteroids to second-line steroid-sparing agents and further to biologicals. This is partially because of varying disease manifestation, but polymorphic genes affecting drug metabolization substantially contribute. This review deals with pharmacogenetic (PGx) factors underlying interindividual differences of treatment response in sarcoidosis regarding personalized approach to patient management...
September 2015: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/25678780/-keep-it-simple-older-african-americans-preferences-for-a-health-literacy-intervention-in-hiv-management
#8
Carrie Ann Gakumo, Comfort C Enah, David E Vance, Efe Sahinoglu, Jim L Raper
PURPOSE: Health literacy is lower in minorities and older adults, and has been associated with nonadherence to medications, treatment, and care in people living with human immunodeficiency virus (HIV). Likewise, African Americans with HIV are more likely to be nonadherent to their HIV medications, less likely to keep their clinic appointments related to HIV treatment and care, and more likely to die during hospitalizations than their ethnic counterparts. The present study explored the preferences of older African Americans with HIV for a health literacy intervention to promote HIV management...
2015: Patient Preference and Adherence
https://www.readbyqxmd.com/read/25618770/exploring-culturally-and-linguistically-diverse-consumer-needs-in-relation-to-medicines-use-and-health-information-within-the-pharmacy-setting
#9
Annim Mohammad, Bandana Saini, Betty Bouad Chaar
BACKGROUND: Low health literacy may result in adverse health outcomes for patients and is a problem faced by countries with multi-ethnic demography. For those of culturally and linguistically diverse (CALD) backgrounds, this problem can be compounded by language barriers such as low English proficiency (LEP). The pharmacy is often the last point of health-care provider contact before patients begin taking their medicines and the first point of care for minor ailments. There is a paucity of data exploring or establishing the needs of this population with respect to general medicine use/health information and pharmacist assistance...
July 2015: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/25482285/clinical-characteristics-of-lichen-and-dysplasia-vs-lichen-planus-cases-and-dysplasia-cases
#10
R Czerninski, S Zeituni, A Maly, J Basile
OBJECTIVES: To compare the clinical characteristics of lichen planus with dysplasia (LD) cases with oral dysplasia (DYS), and LP/lichenoid reaction (LP/LR). METHODS: Patients treated at the Department of Oral Medicine with a histological diagnosis were included. Patient information (age, gender, ethnicity, smoking habits, and medical status) and parameters of oral manifestation (lesions' distribution, site, and type) were compared. RESULTS: Two hundred and thirty five patients were included...
May 2015: Oral Diseases
https://www.readbyqxmd.com/read/25335786/challenges-and-successes-of-a-multidisciplinary-pediatric-obesity-treatment-program
#11
Stephanie M Walsh, Wendy Palmer, Jean A Welsh, Miriam B Vos
BACKGROUND: Despite the well-documented need for multidisciplinary pediatric obesity treatment programs, few programs exist and best practices are not clearly defined. We describe the design and initial quality-related outcomes of the Strong4Life multidisciplinary pediatric obesity treatment program along with some challenges and solutions implemented over the first 2 years. The purpose of this report is to inform others interested in designing similar programs. PROGRAM DESCRIPTION: The Strong4Life Clinic obesity program was designed to provide children with the medical care, as well as the behavior change guidance and support needed to reverse their obesity and/or minimize the related health risks...
December 2014: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/25186789/cultural-barriers-encountered-by-norwegian-community-pharmacists-in-providing-service-to-non-western-immigrant-patients
#12
Helle Håkonsen, Karine Lees, Else-Lydia Toverud
BACKGROUND: Western societies' need for knowledge about how to meet the challenges in health care following increased immigration has emerged as studies have showed that non-Western immigrants tend to experience more obstacles to drug use and poorer communication with health professionals. OBJECTIVES: To identify the cultural barriers encountered by Norwegian community pharmacists in providing service to non-Western immigrant patients and to outline how they are being addressed...
December 2014: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/25150546/cultural-diversity-blind-spot-in-medical-curriculum-documents-a-document-analysis
#13
Emma Paternotte, Joanne P I Fokkema, Karsten A van Loon, Sandra van Dulmen, Fedde Scheele
BACKGROUND: Cultural diversity among patients presents specific challenges to physicians. Therefore, cultural diversity training is needed in medical education. In cases where strategic curriculum documents form the basis of medical training it is expected that the topic of cultural diversity is included in these documents, especially if these have been recently updated. The aim of this study was to assess the current formal status of cultural diversity training in the Netherlands, which is a multi-ethnic country with recently updated medical curriculum documents...
2014: BMC Medical Education
https://www.readbyqxmd.com/read/24979960/partial-edentulism-and-unmet-prosthetic-needs-amongst-young-adult-nigeria
#14
B Akinboboye, C Azodo, M Soroye
INTRODUCTION: Treatment options for missing tooth/teeth which are mostly commonly caused dental caries, periodontitis and trauma include partial dentures, bridge and implant. In developing countries, missing tooth/teeth replacement constitutes a high unmet dental need. The objective of the study was to determine the prevalence of partial edentulism and prosthetic unmet dental needs among young adults in Nigeria. MATERIALS AND METHODS: A total of 244 medical students of college of medicine were recruited and studied using interviewer administered questionnaire which elicited information on sociodemographic, tooth loss and replacement...
March 2014: Odonto-stomatologie Tropicale, Tropical Dental Journal
https://www.readbyqxmd.com/read/24644523/perceptions-of-prescription-warning-labels-within-an-underserved-population
#15
Olayinka O Shiyanbola, Brittney A Meyer, Michelle R Locke, Sara Wettergreen
OBJECTIVE: To understand how underserved populations attend to prescription warning label (PWL) instructions, examine the importance of PWL instructions to participants and describe the challenges associated with interpreting the information on PWLs. METHODS: Adults from an underserved population (racial and ethnic minorities, individuals with low income, older adults) who had a history of prescription medication use and were able to understand English took part in semi-structured interviews...
January 2014: Pharmacy Practice
https://www.readbyqxmd.com/read/24624407/equity-in-statin-use-in-new-zealand
#16
Pauline Norris, Simon Horsburgh, Gordon Becket, Shirley Keown, Bruce Arroll, Kirsten Lovelock, Peter Crampton, Jackie Cumming, Peter Herbison
INTRODUCTION: Preventive medications such as statins are used to reduce cardiovascular risk. There is some evidence to suggest that people of lower socioeconomic position are less likely to be prescribed statins. In New Zealand, Maori have higher rates of cardiovascular disease. AIM: This study aimed to investigate statin utilisation by socioeconomic position and ethnicity in a region of New Zealand. METHODS: This was a cross-sectional study in which data were collected on all prescriptions dispensed from all pharmacies in one city during 2005/6...
March 2014: Journal of Primary Health Care
https://www.readbyqxmd.com/read/24229342/differences-in-the-perceived-role-of-the-healthcare-provider-in-delivering-vascular-health-checks-a-q-methodology-study
#17
Stephanie Honey, Louise D Bryant, Jenny Murray, Kate Hill, Allan House
BACKGROUND: The UK Department of Health introduced the National Health Service (NHS) Health Check Programme in April 2009 in an attempt to improve primary and secondary prevention of cardiovascular disease in the UK population and to reduce health inequalities. Healthcare professionals' attitudes towards giving lifestyle advice will influence how they interact with patients during consultations. We therefore sought to identify the attitudes of primary care healthcare professionals towards the delivery of lifestyle advice in the context of the NHS Health Check Programme...
November 14, 2013: BMC Family Practice
https://www.readbyqxmd.com/read/24025591/ethical-issues-in-research-involving-minority-populations-the-process-and-outcomes-of-protocol-review-by-the-ethics-committee-of-the-faculty-of-tropical-medicine-mahidol-university-thailand
#18
Pornpimon Adams, Waranya Wongwit, Krisana Pengsaa, Srisin Khusmith, Wijitr Fungladda, Warissara Chaiyaphan, Chanthima Limphattharacharoen, Sukanya Prakobtham, Jaranit Kaewkungwal
BACKGROUND: Recruiting minorities into research studies requires special attention, particularly when studies involve "extra-vulnerable" participants with multiple vulnerabilities, e.g., pregnant women, the fetuses/neonates of ethnic minorities, children in refugee camps, or cross-border migrants. This study retrospectively analyzed submissions to the Ethics Committee of the Faculty of Tropical Medicine (FTM-EC) in Thailand. Issues related to the process and outcomes of proposal review, and the main issues for which clarification/revision were requested on studies, are discussed extensively...
2013: BMC Medical Ethics
https://www.readbyqxmd.com/read/23915948/pain-relief-spiritual-needs-and-family-support-three-central-areas-in-intercultural-palliative-care
#19
REVIEW
Ingrid Hanssen, Gry Pedersen
OBJECTIVE: The purpose of this study was to draw out and coalesce the topic-specific information found in research literature regarding the provision of culturally sensitive palliative practice. METHOD: This was a literature study and Gadamerian hermeneutic text analysis. RESULTS: It is more difficult to assess the level of pain in ethnic minority patients, and healthcare providers may become frustrated and interpret pain symptoms as fabrication...
December 2013: Palliative & Supportive Care
https://www.readbyqxmd.com/read/23635686/obstetricians-and-their-role-in-cord-blood-banking-promoting-a-public-model
#20
Mary M Herlihy, Ellen H Delpapa
Umbilical cord blood, the blood remaining in the umbilical cord at birth, can be collected at birth and be a source of stem cells for a patient in need of a bone marrow transplant. Obstetricians and other health care practitioners are recognized as a patient's primary source for medical information affecting the mother and her neonate and frequently are asked to provide education and guidance regarding options of private and public cord blood banking. As the use of cord blood continues to grow in medicine and research uncovers more potential for cord blood, cord blood banking has become an important resource...
April 2013: Obstetrics and Gynecology
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