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https://www.readbyqxmd.com/read/28531887/expression-and-characterization-of-membrane-type-4-matrix-metalloproteinase-mt4-mmp-and-its-different-forms-in-melanoma
#1
Bettina Hieronimus, Julian Pfohl, Christian Busch, Lutz Graeve
BACKGROUND/AIMS: Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT-MMPs are anchored to the plasma membrane via a GPI anchor, one of which is MT4-MMP. Only little is known about MT4-MMP expression, synthesis, regulation and degradation. METHODS: We analyzed several human cancer cell lines as well as tissue homogenates using Western blotting and quantitative PCR for the expression of MT4-MMP...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28515296/hepatitis-c-virus-lipoviroparticles-hcv-lvp-assemble-in-the-endoplasmic-reticulum-er-and-bud-off-from-the-er-to-golgi-in-copii-vesicles
#2
Gulam H Syed, Mohsin Khan, Song Yang, Aleem Siddiqui
Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP). In vitro studies have demonstrated the importance of apolipoproteins in HCV secretion and infectivity leading to the notion that HCV co-opts the secretion of very-low density lipoprotein (VLDL) for its egress. However, our understanding of the mechanisms involved in virus particle assembly and egress, are still elusive. Biogenesis of VLDL particle occurs in the ER followed by subsequent lipidation in the ER and Golgi. Secretion of mature VLDL particles occurs through the Golgi secretory pathway...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28490883/retrospective-analysis-of-non-laboratory-based-adverse-drug-reactions-induced-by-intravenous-radiocontrast-agents-in-a-joint-commission-international-accredited-academic-medical-center-hospital-in-china
#3
Qin-Lan Chen, Xiao-Ying Zhao, Xiao-Mi Wang, Na Lv, Ling-Ling Zhu, Hui-Min Xu, Quan Zhou
The authors retrospectively analyzed the pattern and characteristics of non-laboratory-based adverse drug reactions (ADRs) induced by intravenous radiocontrast agents in a large-scale hospital in China during 2014-2015. There were 314 ADR cases among 118,208 patients receiving enhanced CT or MRI examinations. The frequency of moderate/severe ADRs defined by Chinese Society of Radiology (ie, severe vomiting, systematic urticaria, facial swelling, dyspnea, vasovagal reaction, laryngeal edema, seizure, trembling, convulsions, unconsciousness, shock, death, and other unexpected adverse reactions) was rare (0...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28463024/delayed-genital-blisters-following-iodixanol-administration
#4
Wen Zhang, Wei Yuan, Hai-Ling Yuan, Xiao-Lai Yang, Hua Xie
Iodixanol is a non-ionic contrast medium for general vascular use. The most common adverse effects from iodixanol include skin rashes, hives, erythema, itching, and angioedema. To date, there have been no reports of delayed genital blisters of iodixanol. In this report, we describe a patient in whom iodixanol induced delayed genital blisters one day after digital subtraction angiography.
May 2, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28421628/comparison-of-the-nephrotoxic-effects-of-iodixanol-versus-iohexol-in-patients-with-chronic-heart-failure-undergoing-coronary-angiography-or-angioplasty
#5
Tao Song, Min Song, Zhiming Ge, Yong Li, Peimiao Shi, Menghan Sun
OBJECTIVES: The aim of this clinical trial is to compare iodixanol with iohexol for the incidence of contrast-induced nephropathy in patients with chronic heart failure with reduced ejection fraction who are currently undergoing coronary angiography or angioplasty. METHODS: The clinical trial included 220 consecutive patients with chronic heart failure with reduced ejection fraction undergoing coronary angiography or angioplasty. Study participants were administered either iodixanol (n = 110) or iohexol (n = 110)...
April 19, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28401790/comparison-of-iodixanol-and-iopromide-in-patients-with-renal-insufficiency-and-congestive-heart-failure-undergoing-coronary-angiography-by-hemodynamic-monitoring
#6
Geng Qian, Yong-Qiang Yang, Wei Dong, Feng Cao, Yun-Dai Chen
We investigated the impact of contrast media (CM) with different osmolality on cardiac preload in patients with chronic kidney disease (CKD) and congestive heart failure (CHF). Patients with CKD and CHF were equally randomized to receive either iso-osmolar contrast media (IOCM) iodixanol or low-osmolar contrast media iopromide. We measured cardiac preload indexes by invasive hemodynamic monitoring before and after CM injection. Major adverse cardiac events postprocedures were recorded. Increase in extravascular lung water index was only seen in the iopromide group ( P < ...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28395244/an-isocratic-hydrophilic-interaction-liquid-chromatographic-method-for-simultaneous-determination-of-iodixanol-and-its-related-impurities-in-drug-substance
#7
Bruno D Rondon, Neila M Cassiano, Quezia B Cass
This work reports a simple isocratic hydrophilic interaction liquid chromatographic (HILIC) method for the simultaneous quantification of iodixanol and of its related impurities C, D and E in drug substance. The chromatographic separation was carried out with a Kinetex™ HILIC column, using acetonitrile and formic acid aqueous solution (1.0mmol/L, pH 3.2) (92:08, v/v) as eluent at a flow rate of 0.8mL/min. The autosampler and column temperature were maintained at 20°C and UV detection was set at 243nm. The method was validated in accordance to the ICH guideline and employed for the analysis of two different lots of iodixanol drug substance...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28387639/effect-of-intravenous-administration-of-contrast-media-on-serum-creatinine-levels-in-neonates
#8
Maria A Bedoya, Ammie M White, J Christopher Edgar, Madhura Pradhan, Elisabeth L Raab, James S Meyer
Purpose To assess the effect of intravenous contrast media on renal function in neonates. Materials and Methods Institutional review board approval was obtained with waiver of consent. Electronic health records from January 2011 to April 2013 were reviewed retrospectively. Measures of renal function were obtained in inpatient neonates who underwent magnetic resonance (MR) imaging or computed tomography (CT) and for whom serum creatinine (Cr) levels were obtained within 72 hours before imaging and at least one time after imaging (>1 day after administration of contrast material)...
April 6, 2017: Radiology
https://www.readbyqxmd.com/read/28370846/effects-of-supplementation-of-iodixanol-to-semen-extender-on-quality-and-fertilization-ability-of-frozen-thawed-thai-native-bull-sperm
#9
Phirawit Chuawongboon, Saksiri Sirisathien, Jatuporn Pongpeng, Denpong Sakhong, Takashi Nagai, Thevin Vongpralub
This study investigates the effects of iodixanol supplementation in varied concentrations to Tris egg yolk (TEY) extender on the quality and fertilization ability of frozen-thawed sperm of Thai native bulls. Each ejaculate was divided into four different groups, as follows: sperm were treated with TEY extender (control group) and TEY extender supplemented with three different concentrations of iodixanol (1.25%, 2.50% and 5.00%). Semen straws were frozen in liquid nitrogen vapor. After thawing, sperm motility characteristics, viability, plasma membrane integrity and acrosome integrity were determined...
March 30, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28360862/iodixanol-as-a-contrast-agent-in-a-fibrin-hydrogel-for-endodontic-applications
#10
Gabriel Hertig, Matthias Zehnder, Anna Woloszyk, Thimios A Mitsiadis, Anja Ivica, Franz E Weber
The application of biomaterials used in regenerative endodontics should be traceable. In this study, we checked some basic effects of rendering a fibrin hydrogel radiopaque using an iodine-based contrast agent (iodixanol) approved for systemic application. Fibrin hydrogels were prepared from a fibrin sealant (Tisseel) using either an isotonic iodixanol solution (Visipaque 320, test) or Tris buffer (control) as a diluent. Gelation kinetics, radiopacity, and swelling of lyophilized hydrogels were tested using standard methods...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28345174/overall-evaluability-of-low-dose-protocol-for-computed-tomography-angiography-of-thoracic-aorta-using-80%C3%A2-kv-and-iterative-reconstruction-algorithm-using-different-concentration-contrast-media
#11
Andrea Daniele Annoni, Maria E Mancini, Daniele Andreini, Alberto Formenti, Saima Mushtaq, Enrica Nobili, Marco Guglielmo, Andrea Baggiano, Edoardo Conte, Mauro Pepi
INTRODUCTION: Multidetector Computed Tomography Angiography (MDCTA) is presently the imaging modality of choice for aortic disease. However, the effective radiation dose and the risk related to the use of contrast agents associated with MDCTA is an issue of concern. Aim of this study was to assess image quality of a low dose ECG-gated MDCTA of thoracic aorta using different concentration contrast media without tailored injection protocol. METHODS: Two-hundred patients were randomised into four different scan protocols: Group A (Iodixanol 320 and 80 Kvp tube voltage), Group B (Iodixanol 320 and 100 Kvp tube voltage), Group C (Iomeprol 400 and 80 Kvp tube voltage) and Group D (Iomeprol 400 and 100 Kvp tube voltage)...
March 27, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28335309/separation-of-bacteria-protozoa-and-carbon-nanotubes-by-density-gradient-centrifugation
#12
Monika Mortimer, Elijah J Petersen, Bruce A Buchholz, Patricia A Holden
Sustainable production and use of carbon nanotube (CNT)-enabled materials require efficient assessment of CNT environmental hazards, including the potential for CNT bioaccumulation and biomagnification in environmental receptors. Microbes, as abundant organisms responsible for nutrient cycling in soil and water, are important ecological receptors for studying the effects of CNTs. Quantification of CNT association with microbial cells requires efficient separation of CNT-associated cells from individually dispersed CNTs and CNT agglomerates...
October 12, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28302486/mitochondria-are-devoid-of-amyloid-%C3%AE-protein-a%C3%AE-producing-secretases-evidence-for-unlikely-occurrence-within-mitochondria-of-a%C3%AE-generation-from-amyloid-precursor-protein
#13
Naomi Mamada, Daisuke Tanokashira, Kazuhiro Ishii, Akira Tamaoka, Wataru Araki
Mitochondrial dysfunction is implicated in the pathological mechanism of Alzheimer's disease (AD). Amyloid β-protein (Aβ), which plays a central role in AD pathogenesis, is reported to accumulate within mitochondria. However, a question remains as to whether Aβ is generated locally from amyloid precursor protein (APP) within mitochondria. We investigated this issue by analyzing the expression patterns of APP, APP-processing secretases, and APP metabolites in mitochondria separated from human neuroblastoma SH-SY5Y cells and those expressing Swedish mutant APP...
April 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28267987/prospective-ecg-triggering-cardiac-ct-for-infants-with-complex-congenital-heart-disease-using-low-dose-contrast-medium-low-tube-voltage-and-adaptive-statistical-iterative-reconstruction
#14
S-Y Wang, W Gao, Y-M Zhong, A-M Sun, Q Wang, L-W Hu, H-S Qiu, J-Y Li
AIM: To demonstrate the clinical value of prospective electrocardiography (ECG)-triggered cardiac computed tomography (CT) with low concentration contrast medium, low tube voltage, and adaptive statistic iterative reconstruction (ASIR) to reduce both radiation and contrast dose in examining infants with complex congenital heart disease (CHD). MATERIALS AND METHODS: Forty-four consecutive infants (19 male, 25 female, age: 8.06±4.33 months, weight: 7.31±1.36 kg) with complex CHD underwent prospective ECG-triggered low-dose cardiac CT using 80 kVp and 120 mA...
March 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28248433/application-of-bold-mri-and-dti-for-the-evaluation-of-renal-effect-related-to-viscosity-of-iodinated-contrast-agent-in-a-rat-model
#15
Yi Wang, Ke Ren, Yi Liu, Wen-Ge Sun, Jia-Huan Wang, Xin Zhang, Cheng-Hua Wu
PURPOSE: To evaluate the effects of viscosity of contrast agent (CA) on intrarenal oxygenation and diffusion as measured by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in a rat model. MATERIALS AND METHODS: Radiocontrast iodixanol formulated in three viscosities were designated 270, 320, and 350 (mg iodine/mL). Sixty-three male Wistar rats were divided into four groups. Saline and iodixanol (4 g iodine/kg) were administered...
March 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28240640/comparison-of-270-versus-320-mg-i-ml-of-iodixanol-in-1-image-assessment-of-both-renal-arteries-and-veins-with-dual-energy-spectral-ct-imaging-in-late-arterial-phase-and-their-influence-on-renal-function
#16
Kefeng Zhou, Jian He, Feng Qu, Haijian Fan, Yi Ma, Tingting Shi, Zhengyang Zhou, Bin Zhu
OBJECTIVE: The objective of this study was to compare the image quality of renal arteries and veins with dual-energy spectral computed tomography (CT) imaging in late arterial phase using 270 and 320 mg I/mL of iodixanol and their influence on renal function. METHODS: A total of 1062 patients underwent renal CT angiography with 270 or 320 mg I/mL of iodixanol with dual-energy spectral CT imaging in late arterial phase. Image quality and their influence on renal function were compared...
February 24, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28236133/subjective-and-objective-image-differences-in-pediatric-computed-tomography-cardiac-angiography-using-lower-iodine-concentration
#17
Jae-Yeon Hwang, Ki Seok Choo, Yoon Young Choi, Jin Hyeok Kim, Hwaseong Ryu, Junhee Han, Yong-Woo Kim, Ung Bae Jeon, Kyung Jin Nam
BACKGROUND: Several recent studies showed the optimal contrast enhancement with a low-concentration and iso-osmolar contrast media in both adult and pediatric patients. However, low contrast media concentrations are not routinely used due to concerns of suboptimal enhancement of cardiac structures and small vessels. OBJECTIVE: To evaluate the feasibility of using iso-osmolar contrast media containing a low iodine dose for CT cardiac angiography at 80 kilovolts (kVp) in neonates and infants...
February 24, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28205172/measurement-of-cholesterol-transfer-from-lysosome-to-peroxisome-using-an-in-vitro-reconstitution-assay
#18
Jie Luo, Ya-Cheng Liao, Jian Xiao, Bao-Liang Song
Low-density lipoproteins (LDLs) are taken up by the cell mainly through receptor-mediated endocytosis. LDL-derived cholesterol leaves lysosome and further transports to downstream organelles for specific cellular needs. We recently report that cholesterol transfers from lysosome to peroxisome through lysosome-peroxisome membrane contact (LPMC). Here, we use iodixanol density gradient centrifugation to isolate lysosomes and peroxisomes separately for the in vitro reconstitution of LPMC. We also apply (3)H-cholesterol-labeled lysosomes and peroxisomes in vitro to measure (3)H-cholesterol transfer through LPMC...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28177193/manufacturing-of-recombinant-adeno-associated-viruses-using-mammalian-expression-platforms
#19
REVIEW
Marc-André Robert, Parminder S Chahal, Alexandre Audy, Amine Kamen, Rénald Gilbert, Bruno Gaillet
Manufacturing practices for recombinant adeno-associated viruses (AAV) have improved in the last decade through the development of new platforms in conjunction with better production and purification methods. In this review, we discuss the advantages and limitations of the most popular systems and methods employed with mammalian cell platforms. Methods and systems such as transient transfection, packaging and producer cells and adenovirus and herpes simplex virus are described. In terms of best production yields, they are comparable with about 10(4) -10(5) vector genomes produced per cell but transient transfection of HEK293 cells is by far the most commonly used...
March 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28152568/apolipoprotein-a-inhibits-hepatitis-c-virus-entry-through-interaction-with-infectious-particles
#20
Catarina Oliveira, Carole Fournier, Véronique Descamps, Virginie Morel, Corey A Scipione, Rocco Romagnuolo, Marlys L Koschinsky, Agnès Boullier, Paulo Marcelo, Jean-Marc Domon, Etienne Brochot, Gilles Duverlie, Catherine Francois, Sandrine Castelain, Francois Helle
The development of different cell culture models has greatly contributed to improve the knowledge of the hepatitis C virus (HCV) life cycle. However, it is still challenging to grow HCV clinical isolates in cell culture. This would open new perspectives to study HCV biology, including drug resistant variants emerging with new antiviral therapies. In this study we hypothesized that this hurdle could be due to the presence of inhibitory factors in patient serum. Combining polyethylene glycol precipitation, iodixanol gradient and size-exclusion chromatography, we obtained a purified fraction enriched in inhibitory factors from HCV seronegative sera...
February 2, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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