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https://www.readbyqxmd.com/read/29761547/a-novel-combination-of-silane-coated-silica-colloid-with-hybrid-rna-extraction-protocol-and-rna-enrichment-for-downstream-applications-of-spermatozoal-rna
#1
K Vijayalakshmy, P Kumar, M Virmani, S Pawaria, N S Lalaji, P Sharma, R Rajendran, P S Yadav, D Kumar
Spermatozoa are specialised cells with low RNA content as compared to somatic cells. The suitable sperm RNA extraction and enrichment protocols for downstream applications are available for human, cattle, stallion and mouse but not for buffalo spermatozoa. Therefore, the present work was conducted to find out suitable colloidal solution for sperm purification and appropriate protocol for sperm RNA extraction and enrichment/amplification of RNA. For purification, we used PVP-coated silica colloidal solution (PVP-Si), silane-coated silica colloidal solution (Silane-Si) and iodixanol...
May 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29735908/protective-effect-of-artemisia-argyi-and-its-flavonoid-constituents-against-contrast-induced-cytotoxicity-by-iodixanol-in-llc-pk1-cells
#2
Dahae Lee, Chang-Eop Kim, Sa-Yoon Park, Kem Ok Kim, Nguyen Tuan Hiep, Dongho Lee, Hyuk-Jai Jang, Jae Wook Lee, Ki Sung Kang
Preventive effects and corresponding molecular mechanisms of mugwort ( Artemisia argyi ) extract and its flavonoid constituents on contrast-induced nephrotoxicity were explored in the present study. We treated cultured LLC-PK1 cells with iodixanol to induce contrast-induced nephrotoxicity, and found that A. argyi extracts ameliorated the reduction in cellular viability following iodixanol treatment. The anti-apoptotic effect of A. argyi extracts on contrast-induced nephrotoxicity was mediated by the inhibition of mitogen-activated protein kinase (MAPK) phosphorylation and the activation of caspases...
May 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29718868/iodixanol-versus-iopromide-in-patients-with-renal-insufficiency-undergoing-coronary-angiography-with-or-without-pci
#3
Junyi Zhang, Yufeng Jiang, Qing Rui, Min Chen, Nannan Zhang, Huajia Yang, Yafeng Zhou
BACKGROUND: The use of contrast agents during coronary angiography can result in contrast-induced nephropathy (CIN), particularly in patients with renal dysfunction. On the contrary, different contrast agents can induce different degree of changes in cardiac function. The objective of our meta-analysis was to compare the clinical safety of iso-osmolar contrast medium iodixanol to low-osmolar contrast medium iopromide in patients with renal insufficiency undergoing coronary angiography with or without percutaneous coronary intervention (PCI)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29687326/are-iso-osmolar-as-compared-to-low-osmolar-contrast-media-cost-effective-in-patients-undergoing-cardiac-catheterization-an-economic-analysis
#4
Swapnil Hiremath, Ayub Akbari, George A Wells, Benjamin J W Chow
PURPOSE: Contrast-induced acute kidney injury is a prominent complication following cardiac catheterization, though the risk has progressively decreased in recent times with appropriate risk stratification and use of safer contrast agents. Despite data supporting further lowering of risk with the iso-osmolar agent, iodixanol, uptake has lagged, perhaps due to increased upfront cost of this agent. We undertook an economic analysis to estimate the cost-effectiveness of a strategy utilizing iodixanol compared to using a low-osmolar contrast agent...
April 23, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29680838/mitophagy-plays-a-protective-role-in-iodinated-contrast-induced-acute-renal-tubular-epithelial-cells-injury
#5
Rong Lei, Fei Zhao, Cheng-Yuan Tang, Min Luo, Shi-Kun Yang, Wei Cheng, Xu-Wei Li, Shao-Bin Duan
BACKGROUND/AIMS: Contrast induced-acute kidney injury (CI-AKI) is one of the most common causes of acute kidney injury (AKI) in hospitalized patients. Mitophagy, the selective elimination of mitochondria via autophagy, is an important mechanism of mitochondrial quality control in physiological and pathological conditions. In this study, we aimed to determine effects of iohexol and iodixanol on mitochondrial reactive oxygen species (ROS), mitophagy and the potential role of mitophagy in CI-AKI cell models...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29621273/ultrafiltered-recombinant-aav8-vector-can-be-safely-administered-in-vivo-and-efficiently-transduces-liver
#6
Mark D Kleven, Michelle M Gomes, Aaron M Wortham, Caroline A Enns, Christoph A Kahl
Viral vectors are extensively purified for use in biomedical research, in order to separate biologically active virus particles and to eliminate production related impurities that are assumed to be detrimental to the host. For recombinant adeno-associated virus (rAAV) vectors this is typically accomplished using density gradient-based methods, which are tedious and require specialized ultracentrifugation equipment. In order to streamline the preparation of rAAV vectors for pilot and small animal studies, we recently devised a simple ultrafiltration approach that permits rapid virus concentration and partial removal of production-related impurities...
2018: PloS One
https://www.readbyqxmd.com/read/29558481/contrast-induced-nephropathy-in-patients-with-diabetes-mellitus-between-iso-and-low-osmolar-contrast-media-a-meta-analysis-of-full-text-prospective-randomized-controlled-trials
#7
Xiao-Fang Han, Xin-Xiu Zhang, Ke-Mei Liu, Hua Tan, Qiu Zhang
PURPOSE: This study was conducted to compare iso-osmolar contrast medium, iodixanol, with low-osmolar contrast media (LOCM) for assessing contrast-induced nephropathy (CIN) incidence, exclusively in the diabetic population. METHOD: A systematic search was conducted for full-text, prospective, randomized controlled trials (RCTs). The primary outcome was incidence of CIN. Medline, Cochrane Central Register of Controlled Trials, and other sources were searched until May 31, 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29481204/acoustic-streaming-and-its-suppression-in-inhomogeneous-fluids
#8
Jonas T Karlsen, Wei Qiu, Per Augustsson, Henrik Bruus
We present a theoretical and experimental study of boundary-driven acoustic streaming in an inhomogeneous fluid with variations in density and compressibility. In a homogeneous fluid this streaming results from dissipation in the boundary layers (Rayleigh streaming). We show that in an inhomogeneous fluid, an additional nondissipative force density acts on the fluid to stabilize particular inhomogeneity configurations, which markedly alters and even suppresses the streaming flows. Our theoretical and numerical analysis of the phenomenon is supported by ultrasound experiments performed with inhomogeneous aqueous iodixanol solutions in a glass-silicon microchip...
February 2, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29425536/magnetic-iodixanol-a-novel-contrast-agent-and-its-early-characterization
#9
M C Arokiaraj, E Menesson, N Feltin
AIMS: Contrast-induced nephropathy is a commonly encountered problem in clinical practice. The purpose of the study was to design and develop a novel contrast agent, which could be used to prevent contrast-induced nephropathy in the future. METHODS: In total, 20-220nm magnetic nanoparticles were conjugated with iodixanol, and their radio-opacity and magnetic properties were assessed thereafter. Scanning electron microscopy pictures were acquired. Thereafter, the nanoparticles conjugate was tested in cell culture (HUVEC cells), and Quantibody® assay was studied after cell treatment in 1:5 dilutions for 48h, compared with control...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29408241/major-adverse-renal-and-cardiac-events-following-coronary-angiography-and-cardiac-surgery
#10
Kristen M Tecson, David Brown, James W Choi, Georges Feghali, Gonzalo V Gonzalez-Stawinski, Baron L Hamman, Robert Hebeler, Stuart R Lander, Brian Lima, Srini Potluri, Jeffrey M Schussler, Robert C Stoler, Carlos Velasco, Peter A McCullough
BACKGROUND: Patients at high risk for developing post-procedural complications may receive iodixanol, an iso-osmolar contrast, during coronary angiography to minimize the risk of renal toxicity. For those who additionally require cardiac surgery, the wait-time between angiography and surgery may be a modifiable factor capable of mitigating poor surgical outcomes; however, there have been inconsistsent reports regarding the optimal wait-time. We sought to determine the effects of wait time between angiogram and cardiac surgery, as well as contrast induced acute injury (CI-AKI) on the development of major adverse renal and cardiac events (MARCE)...
February 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29382013/the-pathogenesis-of-iodide-mumps-a-case-report
#11
Guilian Zhang, Tao Li, Heying Wang, Jiao Liu
RELATION: Iodide mumps is an uncommon condition, induced by iodide-containing contrast, and is characterized by a rapid, painless enlargement of the bilateral or unilateral salivary gland. At present, the pathogenesis of iodide mumps is not yet clear. It may be related to an idiosyncratic reaction, a toxic accumulation of iodine in the gland duct, or renal function damage leading to an iodine excretion disorder. This paper reports the clinical manifestations and magnetic resonance imaging results of one case of iodide mumps, which occurred after digital subtraction angiography...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29226736/the-effect-of-major-adverse-renal-cardiovascular-event-marce-incidence-procedure-volume-and-unit-cost-on-the-hospital-savings-resulting-from-contrast-media-use-in-inpatient-angioplasty
#12
Eric Keuffel, Peter A McCullough, Thomas M Todoran, Emmanouil S Brilakis, Swetha R Palli, Michael P Ryan, Candace Gunnarsson
OBJECTIVE: To determine the net economic impact of switching from low-osmolar contrast media (LOCM) to iso-osmolar contrast media (IOCM; iodixanol) in patients undergoing inpatient coronary or peripheral angioplasty in the United States (US). METHODS: A budget impact model (BIM) was developed from a hospital perspective. Nationally representative procedural and contrast media prevalence rates, along with MARCE (major adverse renal cardiovascular event) incidence and episode-related cost data were derived from Premier Hospital Data (October 2014 to September 2015)...
April 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29208767/the-feasibility-of-low-concentration-contrast-and-low-tube-voltage-in-computed-tomography-perfusion-imaging-an-animal-study
#13
Yuning Pan, Aiqin Song, Shizhong Bu, Zhaoqian Chen, Qiuli Huang, Aijing Li
Aim : To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.Method : A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan...
February 28, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29159151/a-case-of-unusual-presentation-of-contrast-induced-encephalopathy-after-cerebral-angiography-using-iodixanol
#14
Jun Chul Park, Jun Hyong Ahn, In Bok Chang, Jae Keun Oh, Ji Hee Kim, Joon Ho Song
Contrast-induced encephalopathy after cerebral angiography is a rare complication and until now, only few cases have been reported. This paper reports on contras-induced encephalopathy mimicking meningoencephalitis after cerebral angiography by using iodixanol, an iso-osmolar non-ionic contrast agent. A 58-year-old woman underwent cerebral angiography for the evaluation of multiple intracranial aneurysms. A few hours later, she had persistent headache, vomiting, fever, and seizures. Brain computed tomography (CT) showed sulcal obliteration of right cerebral hemisphere and cerebrospinal fluid profile was unremarkable...
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29097910/analytical-interference-by-contrast-agents-in-biochemical-assays
#15
Sigrid Otnes, Niels Fogh-Andersen, Janne Rømsing, Henrik S Thomsen
Objective: To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods: The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29074393/dcf1-subcellular-localization-and-its-function-in-mitochondria
#16
Yanlu Chen, Ruili Feng, Guanghong Luo, Jianjian Guo, Yajiang Wang, Yangyang Sun, Lili Zheng, Tieqiao Wen
Dendritic cell factor 1 (DCF1) is a transmembrane protein that plays important roles in regulating neural stem cell differentiation and dendritic spine formation. Apart from its cytoplasmic functions, DCF1 plays a role in autophagy during the regulation of amyloid precursor proteins. However, the subcellular localization of DCF1 remains unknown. Therefore, in this study, DCF1 tagged with green fluorescent protein was transiently expression in HelaS3 and HEK293T cells. The results showed that DCF1 was widely expressed in different organelles, including the mitochondria, Golgi apparatus, endoplasmic reticulum, endosomes and lysosomes...
January 2018: Biochimie
https://www.readbyqxmd.com/read/29048268/density-separation-of-quiescent-yeast-using-iodixanol
#17
Ishtiaque Quasem, Christopher J Luby, Charles R Mace, Stephen M Fuchs
As yeast are starved of nutrients, they enter G0, a quiescent state. Quiescent yeast (Q) cells retain viability for extended periods of time and resume growth following supplementation of missing nutrients. As such, Q cells have become a valuable model for studying longevity and self-renewal of chronologically aged cells. Traditional isolation of Q cells involves a relatively long centrifugation time through a continuous density gradient. Here, we describe a rapid and cost-effective Q-cell isolation technique that uses a single-density, one-step gradient prepared from media containing iodixanol...
October 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29030579/effect-of-iodinated-contrast-media-on-renal-perfusion-a-randomized-comparison-study-in-pigs-using-quantitative-contrast-enhanced-ultrasound-ceus
#18
Philipp Lamby, Friedrich Jung, Stefanie Graf, Lotte Schellenberg, Johannes Falter, Natascha Platz-da-Silva, Stephan Schreml, Lukas Prantl, Ralf P Franke, Ernst M Jung
The administration of iodinated contrast media (CM) can cause microcirculatory disorder leading to acute renal dysfunction. In a prospective, randomized investigation two CM (Iodixanol vs Iopromide) were compared in 16 pigs. Each animal received 10 intra-aortal injections (5 ml Iodixanol or 4.32 ml Iopromide). Microcirculation was assessed using contrast-enhanced ultrasound (CEUS) directly on the kidney surface using time-to-peak (TTP) and blood-volume-analysis. Macroscopic observations were documented...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28958858/hepatitis-e-virus-lifecycle-and-identification-of-3-forms-of-the-orf2-capsid-protein
#19
Claire Montpellier, Czeslaw Wychowski, Ibrahim M Sayed, Jean-Christophe Meunier, Jean-Michel Saliou, Maliki Ankavay, Anne Bull, André Pillez, Florence Abravanel, François Helle, Etienne Brochot, Hervé Drobecq, Rayan Farhat, Cécile-Marie Aliouat-Denis, Juliano G Haddad, Jacques Izopet, Philip Meuleman, Anne Goffard, Jean Dubuisson, Laurence Cocquerel
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. Approximately 2 billion people live in areas endemic for HEV and are at risk of infection. The HEV genome encodes 3 proteins, including the ORF2 capsid protein. Detailed analyses of the HEV life cycle has been hampered by the lack of an efficient viral culture system. METHODS: We performed studies with gt3 HEV cell culture-produced particles and patient blood and stool samples...
January 2018: Gastroenterology
https://www.readbyqxmd.com/read/28936471/analysis-of-hepatitis-c-virus-particle-heterogeneity-in-immunodeficient-human-liver-chimeric-fah-mice
#20
Ursula Andreo, Ype P de Jong, Margaret A Scull, Jing W Xiao, Koen Vercauteren, Corrine Quirk, Michiel C Mommersteeg, Sonia Bergaya, Arjun Menon, Edward A Fisher, Charles M Rice
BACKGROUND & AIMS: Hepatitis C virus (HCV) is a leading cause of chronic liver diseases and the most common indication for liver transplantation in the United States. HCV particles in the blood of infected patients are characterized by heterogeneous buoyant densities, likely owing to HCV association with lipoproteins. However, clinical isolates are not infectious in vitro and the relative infectivity of the particles with respect to their buoyant density therefore cannot be determined, pointing to the need for better in vivo model systems...
November 2017: Cellular and Molecular Gastroenterology and Hepatology
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