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daptomycin safety profile in VRE

Pamela A Moise, George Sakoulas, James A McKinnell, Kenneth C Lamp, Daryl D DePestel, Min J Yoon, Katherine Reyes, Marcus J Zervos
PURPOSE: In light of recent evidence suggesting enhancement of daptomycin activity against vancomycin-resistant Enterococcus (VRE) by ampicillin and other β-lactam antibiotics, we evaluated the safety profile and clinical efficacy of daptomycin with and without concomitant β-lactam antimicrobials in the treatment of VRE (faecium or faecalis) bacteremia from multiple centers across the United States. METHODS: Data were collected retrospectively as part of a larger multicenter registry (The Cubicin Outcomes Registry and Experience)...
July 1, 2015: Clinical Therapeutics
Shervanthi Homer-Vanniasinkam
The need for new, effective agents to treat multidrug-resistant infections continues to grow as more and more bacteria develop resistance that may result in clinical therapeutic failure. This is particularly true for common surgical infections, such as complicated intra-abdominal infections, which frequently involve multiple pathogens, making therapy with a broad-spectrum antibiotic an important treatment intervention, and also for complicated skin infections, which often involve methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE)...
2006: International Journal of Surgery
Su Young Lee, Hong Wei Fan, Joseph L Kuti, David P Nicolau
Daptomycin, the first approved member of the lipopeptide antibiotic class, exhibits potent bactericidal in vitro activity against most Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus species and penicillin-resistant Streptococcus species. Since its approval in 2003 for the treatment of complicated skin and skin structure infections, several review articles have summarised daptomycin's mechanism of action, pharmacokinetics, pharmacodynamics, clinical trials and safety profiles...
July 2006: Expert Opinion on Pharmacotherapy
F P Tally, M Zeckel, M M Wasilewski, C Carini, C L Berman, G L Drusano, F B Oleson
The alarming increase in the incidence of Gram-positive infections, including those caused by resistant bacteria, has sparked renewed interest in novel antibiotics. One such agent is daptomycin, a novel lipopeptide antibiotic with proven bactericidal activity in vitro against all clinically relevant Gram-positive bacteria. These include resistant pathogens, such as vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), glycopeptide intermediately susceptible Staphylococcus aureus (GISA), coagulase-negative staphylococci (CNS) and penicillin-resistant Streptococcus pneumoniae (PRSP), for which there are very few therapeutic alternatives...
August 1999: Expert Opinion on Investigational Drugs
Jeffrey D Alder
Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. In September 2003, daptomycin was approved for the treatment of Gram-positive infections associated with complicated skin and skin structure infections. A key feature of daptomycin is its rapid, concentration-dependent bactericidal activity against significant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate and -resistant S. aureus and vancomycin-resistant Enterococcus faecalis and Enterococcus faecium (VRE)...
February 2005: Drugs of Today
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