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AMP-activated protein kinase

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https://www.readbyqxmd.com/read/29676471/vitamin-d3-regulates-steroidogenesis-in-granulosa-cells-through-amp-activated-protein-kinase-ampk-activation-in-a-mouse-model-of-polycystic-ovary-syndrome
#1
Shabnam Bakhshalizadeh, Fardin Amidi, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in reproductive-aged women. Hormonal abnormality caused by steroidogenesis disturbances appears to be the main culprit of the clinical picture in PCOS. Vitamin D3 could regulate steroidogenesis in granulosa cells, but the mechanism of action of vitamin D3 on steroidogenesis remains unknown. AMP-activated protein kinase (AMPK) has a modulating role in steroid hormone production. We investigated the effect of vitamin D3 on steroidogenesis in cultured granulosa cells of dehydroepiandrosterone-induced PCOS mice and studied the involvement of AMPK signalling pathway in the current process...
April 20, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29676131/-jatrorrhizine-regulates-gluts-with-multiple-manners-for-hypoglycemic-effect-in-insulin-resistance-3t3-l1-adipocytes
#2
Shui-Lan Zhu, Ting Lei, Xu Gao, Jun Tu
This paper aimed to investigate the hypoglycemic effect and relative mechanism of jatrorrhizine in insulin-resistance (IR)-3T3-L1 adipocytes. The 3T3-L1 preadipocytes were used to induce mature adipocytes, then the stable IR model was established with 1 μmol·L⁻¹ dexamethasone. The adipocytes were divided into normal group, IR model group, rosiglitazone positive group and jatrorrhizine group (0.5, 1, 5, 10, 20 μmol·L⁻¹). After different time points (12, 24, 30, 36, 48 h) treatment, glucose content of 3T3-L1 adipocytes was detected by the glucose oxidase peroxidase method and TG content was measured by glycerol phosphate oxidase method, whereas cell viability was detected by CCK-8 assay...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675553/a-potential-strategy-for-treating-atherosclerosis-improving-endothelial-function-via-amp-activated-protein-kinase
#3
REVIEW
Feng Gao, Jiemei Chen, Haibo Zhu
Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase (AMPK) is an important metabolic switch that plays a crucial role in lipid metabolism and inflammation. However, recent evidence indicates that AMPK could be a target for atherosclerosis by improving endothelial function. For instance, activation of AMPK inhibits the production of reactive oxygen species induced by mitochondrial dysfunction, ER stress, and NADPH oxidase...
April 16, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29674687/celecoxib-exerts-protective-effects-in-the-vascular-endothelium-via-cox-2-independent-activation-of-ampk-creb-nrf2-signalling
#4
Fahad Al-Rashed, Damien Calay, Marie Lang, Clare C Thornton, Andrea Bauer, Allan Kiprianos, Dorian O Haskard, Anusha Seneviratne, Joseph J Boyle, Alex H Schönthal, Caroline P Wheeler-Jones, Justin C Mason
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674003/tanshinone-iia-suppresses-fc%C3%AE%C2%B5ri-mediated-mast-cell-signaling-and-anaphylaxis-by-activation-of-the-sirt1-lkb1-ampk-pathway
#5
Xian Li, Soon Jin Park, Fansi Jin, Yifeng Deng, Ju Hye Yang, Jae-Hoon Chang, Dong-Young Kim, Jung-Ae Kim, Youn Ju Lee, Makoto Murakami, Kun Ho Son, Hyeun Wook Chang
AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1) and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently reported that the AMPK pathway negatively regulates mast cell activation and anaphylaxis. Tanshinone IIA (Tan IIA), an active component of Salvia miltiorrhiza extract that is currently used for the treatment of cardiovascular and cerebrovascular diseases, shows anti-diabetic activity and improves insulin resistance in db/db mice through activation of AMPK...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673898/activation-of-liver-ampk-with-pf-06409577-corrects-nafld-and-lowers-cholesterol-in-rodent-and-primate-preclinical-models
#6
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, Emily A Day, Chuong Nguyen, Kieran F Geoghegan, John M Kreeger, Alan Opsahl, Jessica Ward, Amit S Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F Osborne, Gregory R Steinberg, Morris J Birnbaum, Kimberly O Cameron, Russell A Miller
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been proposed as a treatment for metabolic diseases; we show that the AMPK β1-biased activator PF-06409577 is capable of lowering hepatic and systemic lipid and cholesterol levels in both rodent and monkey preclinical models...
April 8, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29673133/role-of-the-erk1-2-signaling-pathway-in-the-replication-of-jun%C3%A3-n-and-tacaribe-viruses
#7
Jesús E Brunetti, Sabrina Foscaldi, Verónica M Quintana, Luis A Scolaro, Nora López, Viviana Castilla
We have previously shown that the infection of cell cultures with the arenaviruses Junín (JUNV), Tacaribe (TCRV), and Pichindé promotes the phosphorylation of mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases 1 and 2 (ERK1/2) and that this activation is required for the achievement of a productive infection. Here we examined the contribution of ERK1/2 in early steps of JUNV and TCRV multiplication. JUNV adsorption, internalization, and uncoating were not affected by treatment of cultured cells with U0126, an inhibitor of the ERK1/2 signaling pathway...
April 17, 2018: Viruses
https://www.readbyqxmd.com/read/29670844/the-eeffect-of-metformin-combined-with-calcium-vitamin-d-3-against-diet-induced-nonalcoholic-fatty-liver-disease
#8
Sara Shojaei Zarghani, Samin Abbaszadeh, Mohammad Alizadeh, Maryam Rameshrad, Alireza Garjani, Hamid Soraya
Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670053/testosterone-dependent-mir-26a-5p-and-let-7g-5p-act-as-signaling-mediators-to-regulate-sperm-apoptosis-via-targeting-pten-and-pmaip1
#9
Jideng Ma, Yu Fan, Jinwei Zhang, Siyuan Feng, Zihui Hu, Wanling Qiu, Keren Long, Long Jin, Qianzi Tang, Xun Wang, Qi Zhou, Yiren Gu, Weihang Xiao, Lingyan Liu, Xuewei Li, Mingzhou Li
Recent evidence suggests that testosterone deficiency can dramatically decrease the quality of sperm. MicroRNAs (miRNAs) are conserved mediators of post-transcriptional gene regulation in eukaryotes. However, the systemic regulation and function of miRNAs in sperm quality decline induced by testosterone deficiency has not been investigated. Here, we found that the sperm apoptosis was significantly enhanced and the sperm motility was dramatically decreased in hemicastrated pigs. We then used small RNA sequencing to detect miRNA profiles of sperm from pigs with prepubertal hemicastration (HC) and compared them with control libraries...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29667822/ypaoamides-b-and-c-linear-lipopeptides-from-an-okeania-sp-marine-cyanobacterium
#10
Kosuke Sueyoshi, Miki Yamada, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey's analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose uptake in cultured rat L6 myotubes. In particular, ypaoamide B (1) showed potent activity and activated AMP-activated protein kinase.
April 18, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29667627/propofol-inhibits-hela-cells-by-impairing-autophagic-flux-via-amp-activated-protein-kinase-ampk-activation-and-endoplasmic-reticulum-stress-regulated-by-calcium
#11
Xi Chen, Kai Li, Guoqing Zhao
BACKGROUND Propofol has antitumor effects against various cancers. However, the mechanism of action of propofol in HeLa human cervical cancer cells has not been elucidated. MATERIAL AND METHODS We treated HeLa human cervical cancer cells with different concentrations of propofol. Cell viability was evaluated with Cell Counting Kit-8 and apoptosis was analyzed by annexin V-fluorescein isothiocyanate and propidium iodide staining and flow cytometry. Autophagosome formation was evaluated based on microtubule-associated protein light chain (LC)3 conversion and light chain 3 puncta formation...
April 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29666899/altered-mitochondrial-bioenergetics-and-ultrastructure-in-the-skeletal-muscle-of-young-adults-with-type-1-diabetes
#12
Cynthia M F Monaco, Meghan C Hughes, Sofhia V Ramos, Nina E Varah, Christian Lamberz, Fasih A Rahman, Chris McGlory, Mark A Tarnopolsky, Matthew P Krause, Robert Laham, Thomas J Hawke, Christopher G R Perry
AIMS/HYPOTHESIS: A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes. METHODS: Physically active, young adults (men and women) with type 1 diabetes (HbA1c 63.0 ± 16.0 mmol/mol [7.9% ± 1.5%]) and without type 1 diabetes (control), matched for sex, age, BMI and level of physical activity, were recruited (n = 12/group) to undergo vastus lateralis muscle microbiopsies...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29666569/inhibitory-effects-of-betulinic-acid-on-lps-induced-neuroinflammation-involve-m2-microglial-polarization-via-camkk%C3%AE-dependent-ampk-activation
#13
Chuwen Li, Chao Zhang, Hefeng Zhou, Yu Feng, Fan Tang, Maggie P M Hoi, Chengwei He, Dan Ma, Chao Zhao, Simon M Y Lee
In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory properties. Here, we aim to investigate the potential effects of BA on microglial phenotype polarization and to reveal the underlying mechanisms of action. First, we confirmed that BA promoted M2 polarization and inhibited M1 polarization in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29663879/anti-cancer-effects-of-metformin-recent-evidences-for-its-role-in-prevention-and-treatment-of-cancer
#14
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Warda Kamal, Mohammad A Kamal
Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyperinsulinemia, and Insulin-like growth factor 1 (IGF-1) level was considered its indirect effects...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29662489/immunological-approaches-towards-cancer-and-inflammation-a-cross-talk
#15
REVIEW
Xinglong Qu, Ying Tang, Shucheng Hua
The inflammation is the protective response of the body against various harmful stimuli; however, the aberrant and inappropriate activation tends to become harmful. The acute inflammatory response tends to resolved once the offending agent is subside but this acute response becomes chronic in nature when the body is unable to successfully neutralized the noxious stimuli. This chronic inflammatory microenvironment is associated with the release of various pro-inflammatory and oncogenic mediators such as nitric oxide (NO), cytokines [IL-1β, IL-2, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)], growth factor, and chemokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29662080/involvement-of-amp-activated-protein-kinase-ampk-in-regulation-of-cell-membrane-potential-in-a-gastric-cancer-cell-line
#16
Lin Zhu, Xiao-Jian Yu, Sheng Xing, Feng Jin, Wei-Jun Yang
Membrane potential (Vmem ) is a key bioelectric property of non-excitable cells that plays important roles in regulating cell proliferation. However, the regulation of Vmem itself remains largely unexplored. We found that, under nutrient starvation, during which cell division is inhibited, MKN45 gastric cancer cells were in a hyperpolarized state associated with a high intracellular chloride concentration. AMP-activated protein kinase (AMPK) activity increased, and expression of cystic fibrosis transmembrane conductance regulator (CFTR) decreased, in nutrient-starved cells...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662023/serum-is-not-necessary-for-prior-pharmacological-activation-of-ampk-to-increase-insulin-sensitivity-of-mouse-skeletal-muscle
#17
Nicolas O Jørgensen, Jørgen F P Wojtaszewski, Rasmus Kjøbsted
Exercise, contraction, and pharmacological activation of AMP-activated protein kinase (AMPK) by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) have all been shown to increase muscle insulin sensitivity for glucose uptake. Intriguingly, improvements in insulin sensitivity following contraction of isolated rat and mouse skeletal muscle and prior AICAR stimulation of isolated rat skeletal muscle seem to depend on an unknown factor present in serum. One study recently questioned this requirement of a serum factor by showing serum-independency with muscle from old rats...
April 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29659527/anti-diabetic-effects-and-anti-inflammatory-effects-of-laminaria-japonica-and-hizikia-fusiforme-in-skeletal-muscle-in-vitro-and-in-vivo-model
#18
Sae-Ym Kang, Eunyoung Kim, Inhae Kang, Myoungsook Lee, Yunkyoung Lee
Laminaria japonica ( LJ ) and Hizikia fusiforme ( HF ) are brown seaweeds known to have various health-promoting effects. In this study, we investigated the anti-diabetic effects and possible mechanism(s) of LJ and HF by using both in vitro and in vivo models. C2C12 myotubes, mouse-derived skeletal muscle cells, treated with LF or HF extracts were used for the in vitro model, and muscle tissues from C57BL/6N mice fed a high-fat diet supplemented with 5% LF or HF for 16 weeks were used for the in vivo model...
April 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29659176/nrf2-attenuates-inflammatory-response-in-copd-emphysema-crosstalk-with-wnt3a-%C3%AE-catenin-and-ampk-pathways
#19
Wenhui Cui, Zhihui Zhang, Panpan Zhang, Jiao Qu, Cheng Zheng, Xiaoting Mo, Wencheng Zhou, Liang Xu, Hongwei Yao, Jian Gao
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and abnormal inflammatory response. Wnt/β-catenin and AMP-activated protein kinase (AMPK) have been shown to modulate lung inflammatory responses and injury. However, it remains elusive whether Wnt/β-catenin and AMPK modulate nuclear factor erythroid-2 related factor-2 (Nrf2)-mediated protective responses during the development of emphysema. Here we showed that treatment with a Wnt pathway activator (LiCl) reduced elastase-induced airspace enlargement and cigarette smoke extract (CSE)-induced lung inflammatory responses in WT mice, which was associated with increased activation of Nrf2 pathway...
April 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29658605/aerobic-exercise-regulates-blood-lipid-and-insulin-resistance-via-the-toll%C3%A2-like-receptor-4%C3%A2-mediated-extracellular-signal%C3%A2-regulated-kinases-amp%C3%A2-activated-protein-kinases-signaling-pathway
#20
Mei Wang, Sen Li, Fubaihui Wang, Jinhui Zou, Yanfeng Zhang
Diabetes mellitus is a complicated metabolic disease with symptoms of hyperglycemia, insulin resistance, chronic damage and dysfunction of tissues, and metabolic syndrome for insufficient insulin production. Evidence has indicated that exercise treatments are essential in the progression of type‑ІІ diabetes mellitus, and affect insulin resistance and activity of islet β‑cells. In the present study, the efficacy and signaling mechanism of aerobic exercise on blood lipids and insulin resistance were investigated in the progression of type‑ІІ diabetes mellitus...
April 11, 2018: Molecular Medicine Reports
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