Karin J Bosma, Spencer R Andrei, Liora S Katz, Ashley A Smith, Jennifer C Dunn, Valerie F Ricciardi, Marisol A Ramirez, Sharon Baumel-Alterzon, William A Pace, Darian T Carroll, Emily M Overway, Elysa M Wolf, Michelle E Kimple, Quanhu Sheng, Donald K Scott, Richard M Breyer, Maureen Gannon
OBJECTIVE: Type 2 diabetes is characterized by hyperglycemia and inflammation. Prostaglandin E2 , which signals through four G protein-coupled receptors (EP1-4), is a mediator of inflammation and is upregulated in diabetes. We have shown previously that EP3 receptor blockade promotes β-cell proliferation and survival in isolated mouse and human islets ex vivo. Here, we analyzed whether systemic EP3 blockade could enhance β-cell mass and identity in the setting of type 2 diabetes using mice with a spontaneous mutation in the leptin receptor (Leprdb )...
December 2021: Molecular Metabolism