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https://www.readbyqxmd.com/read/29772955/current-trends-and-future-perspectives-in-pelvic-reconstructive-surgery
#1
Mélanie Aubé, Le Mai Tu
Pelvic organ prolapse is a prevalent disorder with a high lifetime incidence of surgical repair. Pelvic organ prolapse surgery has greatly evolved over the past years, and pelvic floor reconstructive surgeons are faced with a vast array of treatment options for their patients. Our review article illustrates the current trends and future perspectives for the surgical treatment of pelvic organ prolapse.
January 2018: Women's Health
https://www.readbyqxmd.com/read/29769289/metarrestin-a-perinucleolar-compartment-inhibitor-effectively-suppresses-metastasis
#2
Kevin J Frankowski, Chen Wang, Samarjit Patnaik, Frank J Schoenen, Noel Southall, Dandan Li, Yaroslav Teper, Wei Sun, Irawati Kandela, Deqing Hu, Christopher Dextras, Zachary Knotts, Yansong Bian, John Norton, Steve Titus, Marzena A Lewandowska, Yiping Wen, Katherine I Farley, Lesley Mathews Griner, Jamey Sultan, Zhaojing Meng, Ming Zhou, Tomas Vilimas, Astin S Powers, Serguei Kozlov, Kunio Nagashima, Humair S Quadri, Min Fang, Charles Long, Ojus Khanolkar, Warren Chen, Jinsol Kang, Helen Huang, Eric Chow, Esthermanya Goldberg, Coral Feldman, Romi Xi, Hye Rim Kim, Gary Sahagian, Susan J Baserga, Andrew Mazar, Marc Ferrer, Wei Zheng, Ali Shilatifard, Jeffrey Aubé, Udo Rudloff, Juan Jose Marugan, Sui Huang
Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of cancer cells, as a phenotypic marker for a high-content screen of over 140,000 structurally diverse compounds. Metarrestin, obtained through optimization of a screening hit, disassembles PNCs in multiple cancer cell lines, inhibits invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects...
May 16, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29760349/identification-of-novel-potential-acetate-oxidizing-bacteria-in-an-acetate-fed-methanogenic-chemostat-based-on-dna-stable-isotope-probing
#3
Hui-Zhong Wang, Min Gou, Yue Yi, Zi-Yuan Xia, Yue-Qin Tang
Acetate is a significant intermediate of anaerobic fermentation. There are two pathways for converting acetate to CH4 and CO2 : acetoclastic methanogenesis by acetoclastic methanogens, and syntrophic acetate oxidation by acetate-oxidizing bacteria (AOB) and hydrogenotrophic methanogens. Detailed investigations of syntrophic acetate-oxidizing bacteria (SAOB) should contribute to the elucidation of the microbial mechanisms of methanogenesis. In this study, we investigated the major phylogenetic groups of acetate-utilizing bacteria (AUB) in a mesophilic methanogenic chemostat fed with acetate as the sole carbon source by using DNA stable isotope probing (SIP) technology...
May 11, 2018: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/29753082/criteria-to-determine-reliability-of-non-invasive-assessment-of-liver-fibrosis-with-virtual-touch-quantification
#4
Jerome Boursier, Christophe Cassinotto, Gilles Hunault, Sarah Shili, Jerome Lebigot, Bruno Lapuyade, Adrien Lannes, Jean-Baptiste Hiriart, Victoire Cartier, Brigitte Le Bail, Sophie Michalak, Amaury Mouries, Frederic Oberti, Faiza Chermak, Isabelle Fouchard-Hubert, Paul Cales, Christophe Aube, Victor de Ledinghen
BACKGROUND & AIMS: Virtual Touch Quantification (VTQ) evaluates liver fibrosis in patients with chronic liver diseases by measuring shear wave speed in the liver. We aimed to determine the reliability criteria of VTQ examination. METHODS: We performed a prospective study of 1094 patients with chronic liver disease from November 2009 through October 2016 at Angers University Hospital, and between April 2010 and May 2015 at Bordeaux University Hospital, in France...
May 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29735528/a-critical-role-for-nucleoporin-358-nup358-in-transposon-silencing-and-pirna-biogenesis-in-drosophila
#5
Rasesh Y Parikh, Haifan Lin, Vamsi K Gangaraju
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs that bind Piwi proteins to silence transposons and to regulate gene expression. In Drosophila germ cells, the Aubergine (Aub)-Argonaute 3 (Ago3)-dependent ping-pong cycle generates most germline piRNAs. Loading of anti-sense piRNAs amplified by this cycle enables Piwi to enter the nucleus and silence transposons. Nuclear localization is crucial for Piwi function in transposon silencing, but how this process is regulated remains unknown. It is also not known whether any of the components of the nuclear pore complex (NPC) directly function in the piRNA pathway...
May 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29731212/no-292-abnormal-uterine-bleeding-in-pre-menopausal-women
#6
Sukhbir Singh, Carolyn Best, Sheila Dunn, Nicholas Leyland, Wendy Lynn Wolfman
BACKGROUND: Abnormal uterine bleeding is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for this problem during their reproductive years. This guideline replaces previous clinical guidelines on the topic and is aimed to enable health care providers with the tools to provide the latest evidence-based care in the diagnosis and the medical and surgical management of this common problem...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29702269/uterine-tumours-resembling-ovarian-sex-cord-tumours-utrosct-identified-at-resectoscopic-endometrial-ablation-report-of-two-cases
#7
Angelos G Vilos, Cici Zhu, Basim Abu-Rafea, Helen C Ettler, Michele M Weir, George A Vilos
STUDY OBJECTIVE: To report two cases and the clinical significance of UTROSCT found at hysteroscopic endometrial ablation despite benign preoperative endometrial biopsies and imaging suggestive of leiomyoma. DESIGN: Case Report DESIGN CLASSIFICATION: Level III SETTING: Tertiary Care Hospital PATIENTS: Two patients with abnormal uterine bleeding (AUB) INTERVENTIONS: Hysteroscopic endometrial ablation/resection MEASUREMENTS: Pathology of intrauterine tissue/lesions obtained by curettage or resection...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29690320/copelatus-erichson-from-the-dominican-republic-with-the-description-of-a-new-species-comments-on-elytral-striation-and-faunistic-notes-on-antillean-species-coleoptera-dytiscidae-copelatinae
#8
MichaËl Manuel, Albert Deler-hernÁndez, Yoandri S Megna, JiŘÍ HÁjek
The species of the genus Copelatus Erichson, 1832 occurring in the Dominican Republic are reviewed. Five species are recorded, with recent collecting data provided for four of them. Copelatus martini sp. nov., a member of the consors species group, is described and illustrated. It is compared to the apparently similar species C. guadelupensis Legros, 1948 based on morphological characters and on partial sequences of the CO1 gene. Interesting cases of intraspecific variability in the number of elytral dorsal striae in C...
March 21, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687979/evaluating-the-association-between-artificial-light-at-night-exposure-and-breast-and-prostate-cancer-risk-in-spain-mcc-spain-study
#9
Ariadna Garcia-Saenz, Alejandro Sánchez de Miguel, Ana Espinosa, Antonia Valentin, Núria Aragonés, Javier Llorca, Pilar Amiano, Vicente Martín Sánchez, Marcela Guevara, Rocío Capelo, Adonina Tardón, Rosana Peiró-Perez, José Juan Jiménez-Moleón, Aina Roca-Barceló, Beatriz Pérez-Gómez, Trinidad Dierssen-Sotos, Tania Fernández-Villa, Conchi Moreno-Iribas, Victor Moreno, Javier García-Pérez, Gemma Castaño-Vinyals, Marina Pollán, Martin Aubé, Manolis Kogevinas
BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013...
April 23, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29657247/protective-effect-of-taohong-siwu-decoction-on-abnormal-uterine-bleeding-induced-by-incomplete-medical-abortion-in-rats-during-early-pregnancy
#10
Yanyan Zhang, Jichen Wang, Chijing Zuo, Weidong Chen, Qian Zhu, Dongdong Guo, Huanru Wu, Huizhuo Wang, Daiyin Peng, Lan Han
Abnormal uterine bleeding (AUB) induced by incomplete abortion is a common gynecological disease. Taohong Siwu decoction (TSD) is a traditional Chinese medicine (TCM) formula, which has been developed to treat AUB for hundreds of years. In this study, rats had incomplete abortion induced in early pregnancy using mifepristone and misoprostol. The duration and quantity of uterine bleeding were recorded and measured. The pathologic histologic grade was evaluated by hematoxylin-eosin staining (HE). Estradiol (E2 ) and progesterone (P) levels were measured by enzyme linked immunosorbent assays (ELISA)...
April 14, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29628726/abnormal-uterine-bleeding-evaluation-by-endometrial-aspiration
#11
Pratibha Singh
Endometrial evaluation is generally indicated in cases presenting with abnormal uterine bleeding (AUB), especially in women more than 35 years of age. AUB encompasses a variety of presentation, for example, heavy menstrual bleeding, frequent bleeding, irregular vaginal bleeding, postcoital and postmenopausal bleeding to name a few. Many methods are used for the evaluation of such cases, with most common being sonography and endometrial biopsy with very few cases requiring more invasive approach like hysteroscopy...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29606892/management-of-abnormal-uterine-bleeding-focus-on-ambulatory-hysteroscopy
#12
REVIEW
Shilpa Kolhe
The rapid evolution in ambulatory hysteroscopy (AH) has transformed the approach to diagnose and manage abnormal uterine bleeding (AUB). The medical management in primary care remains the mainstay for initial treatment of this common presentation; however, many women are referred to secondary care for further evaluation. To confirm the diagnosis of suspected intrauterine pathology, the traditional diagnostic tool of day case hysteroscopy and dilatation and curettage in a hospital setting under general anesthesia is now no longer required...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29602146/morphometric-investigations-to-assess-the-compatibility-of-mandible-and-skull
#13
Sandra Preissler, Marcel A Verhoff, Frank Ramsthaler, Franziska Holz, Axel Gehl, Sarah C Koelzer
When a morphologically separated skull and mandible are found in the same case context, the possibility of a match arises. Two criteria with which to determine a match are the rough articulation between the mandibular condyles and cranial base itself and, most importantly, the fit of the teeth. However, when there has been intravital or postmortem tooth loss, this important criterion is not available. To date, only Reichs (1989) has investigated further compatibility criteria to solve the question of putative commingling in a case where a mandible seemed to originate from a female, while all other bones originated from a male individual...
March 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29570003/economic-evaluation-of-global-endometrial-ablation-versus-inpatient-and-outpatient-hysterectomy-for-treatment-of-abnormal-uterine-bleeding-us-commercial-and-medicaid-payer-perspectives
#14
Jeffrey D Miller, Machaon M Bonafede, Qian Cai, Scott K Pohlman, Kathleen A Troeger, Aarathi Cholkeri-Singh
Every year, abnormal uterine bleeding (AUB) exacts a heavy toll on women's health and leads to high costs for the US health care system. The literature shows that endometrial ablation results in fewer complications, shorter recovery and lower costs than more commonly performed hysterectomy procedures. The objective of this study was to model clinical-economic outcomes, budget impact, and cost-effectiveness of global endometrial ablation (GEA) versus outpatient hysterectomy (OPH) and inpatient hysterectomy (IPH) procedures...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29569162/cranial-secular-change-from-the-nineteenth-to-the-twentieth-century-in-modern-german-individuals-compared-to-modern-euro-american-individuals
#15
Katharina Jellinghaus, Katharina Hoeland, Carolin Hachmann, Andreas Prescher, Michael Bohnert, Richard Jantz
Studying secular changes on human skulls is a central issue in anthropological research, which is however insufficiently investigated for modern German populations. With our study, we focus on morphological cranial variations within Germans during the nineteenth and twentieth centuries. To study this, we recorded different facial landmarks from a cohort study of about 540 German individuals of different age and sex by calculating their cranial size, shape dimensions, and cranial module and cranial capacity to get information about variations occurring during the decades...
March 22, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29540335/-definition-description-clinicopathological-features-pathogenesis-and-natural-history-of-endometriosis-cngof-has-endometriosis-guidelines
#16
B Borghese, P Santulli, L Marcellin, C Chapron
Endometriosis and adenomyosis are histologically defined. The frequency of endometriosis cannot be precisely estimated in the general population. Endometriosis is considered a disease when it causes pain and/or infertility. Endometriosis is a heterogeneous disease with three well-recognized subtypes that are often associated with each other: superficial endometriosis (SUP), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). DIE is frequently multifocal and mainly affects the following structures: the uterosacral ligaments, the posterior vaginal cul-de-sac, the bladder, the ureters, and the digestive tract (rectum, recto-sigmoid junction, appendix)...
March 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29537383/abnormal-uterine-bleeding-in-adolescents
#17
Selin Elmaoğulları, Zeyra Aycan
Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Additionally, endocrine disorders such as hypothyroidism, hyperprolactinemia and polycystic ovary syndrome (PCOS) are possible causes of AUB...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29531043/structural-insights-into-the-sequence-specific-recognition-of-piwi-by-drosophila-papi
#18
Yuhan Zhang, Weiwei Liu, Ronghong Li, Jiaqi Gu, Ping Wu, Chao Peng, Jinbiao Ma, Ligang Wu, Yang Yu, Ying Huang
The Tudor domain-containing (Tdrd) family proteins play a critical role in transposon silencing in animal gonads by recognizing the symmetrically dimethylated arginine (sDMA) on the (G/A)R motif of the N-terminal of PIWI family proteins via the eTud domains. Papi, also known as "Tdrd2," is involved in Zucchini-mediated PIWI-interacting RNA (piRNA) 3'-end maturation. Intriguingly, a recent study showed that, in papi mutant flies, only Piwi-bound piRNAs increased in length, and not Ago3-bound or Aub-bound piRNAs...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29515433/structure-activity-investigation-of-a-g-protein-biased-agonist-reveals-molecular-determinants-for-biased-signaling-of-the-d-2-dopamine-receptor
#19
Lani S Chun, Rakesh H Vekariya, R Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A Laporte, Amy E Moritz, Jeffrey Aubé, Kevin J Frankowski, David R Sibley
The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissection of these pathways is through the use of drugs that can selectively modulate one pathway vs. the other through a mechanism known as functional selectivity or biased signaling. Our laboratory has previously described a G protein signaling-biased agonist, MLS1547, for the D2R using a variety of in vitro functional assays...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29507290/reagent-controlled-regiodivergent-ring-expansions-of-steroids
#20
Manwika Charaschanya, Jeffrey Aubé
Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such reactions are often limited by the tendency of a given substrate to afford only one of the two rearrangement products or fail to achieve high selectivity at all. These limitations are particularly acute when seeking to carry out late-stage functionalization of natural products as starting points in drug discovery. In this work, we present a stereoelectronically controlled ring expansion sequence towards selective and flexible access to complementary ring systems derived from common steroidal substrates...
March 5, 2018: Nature Communications
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