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https://www.readbyqxmd.com/read/29139552/critical-evaluation-of-the-palm-coein-classification-system-among-women-with-abnormal-uterine-bleeding-in-low-resource-settings
#1
Divya Shubham, Anjali S Kawthalkar
OBJECTIVE: To assess the feasibility of the PALM-COEIN system for the classification of abnormal uterine bleeding (AUB) in low-resource settings and to suggest modifications. METHODS: A prospective study was conducted among women with AUB who were admitted to the gynecology ward of a tertiary care hospital and research center in central India between November 2014 and October 2016. All patients were managed as per department protocols. The causes of AUB were classified before treatment using the PALM-COEIN system (classification I) and on the basis of the histopathology reports of the hysterectomy specimens (classification II); the results were compared using classification II as the gold standard...
November 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29139384/-seronegative-myasthenia-gravis
#2
Oana Catar, Anne-Catherine Aubé-Nathier, Aleksandra Nadaj-Pakleza
No abstract text is available yet for this article.
November 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29128205/endometrial-ablation
#3
REVIEW
Malcolm G Munro
Endometrial ablation (EA) includes a spectrum of procedures performed with or without hysteroscopic direction, designed to destroy the endometrium for the treatment of the symptom of heavy menstrual bleeding (HMB) secondary to a spectrum of causes, but most commonly those that are endometrial in origin (AUB-E) or ovulatory disorders (AUB-O). Resectoscopic endometrial ablation (REA) is often mistakenly referred to as the "first generation" technique, while proprietary devices that do not use the resectoscope (nonresectoscopic EA or NREA) are often misperceived as "second generation" devices...
October 20, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29113655/laparoscopic-partial-nephrectomy-following-tumor-embolization-in-a-hybrid-room-feasibility-and-clinical-outcomes
#4
Paul Panayotopoulos, Antoine Bouvier, Louis Besnier, Marie Christine Rousselet, Cosmina Nedelcu, Nathalie Baize, Laurent Beydon, Christophe Aubé, Abdel-Rahmène Azzouzi, Pierre Bigot
PURPOSE: In order to limit ischemia and operative bleeding during and after partial nephrectomy we developed a clampless laparoscopic technique, in a hybrid operating room, immediately after super-selective arterial embolization of the renal tumor. We evaluated feasibility and morbidity of this new approach of zero ischemia in partial nephrectomy. METHODS: We included prospectively 50 consecutive patients treated in a hybrid operating room by this new technique for a localized renal tumor in a university hospital between May 2015 and January 2017...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29107679/efficacy-and-safety-of-selective-internal-radiotherapy-with-yttrium-90-resin-microspheres-compared-with-sorafenib-in-locally-advanced-and-inoperable-hepatocellular-carcinoma-sarah-an-open-label-randomised-controlled-phase-3-trial
#5
Valérie Vilgrain, Helena Pereira, Eric Assenat, Boris Guiu, Alina Diana Ilonca, Georges-Philippe Pageaux, Annie Sibert, Mohamed Bouattour, Rachida Lebtahi, Wassim Allaham, Hélène Barraud, Valérie Laurent, Elodie Mathias, Jean-Pierre Bronowicki, Jean-Pierre Tasu, Rémy Perdrisot, Christine Silvain, René Gerolami, Olivier Mundler, Jean-Francois Seitz, Vincent Vidal, Christophe Aubé, Frédéric Oberti, Olivier Couturier, Isabelle Brenot-Rossi, Jean-Luc Raoul, Anthony Sarran, Charlotte Costentin, Emmanuel Itti, Alain Luciani, René Adam, Maïté Lewin, Didier Samuel, Maxime Ronot, Aurelia Dinut, Laurent Castera, Gilles Chatellier
BACKGROUND: Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma. We aimed to compare the efficacy and safety of sorafenib to that of selective internal radiotherapy (SIRT) with yttrium-90 ((90)Y) resin microspheres in patients with hepatocellular carcinoma. METHODS: SARAH was a multicentre, open-label, randomised, controlled, investigator-initiated, phase 3 trial done at 25 centres specialising in liver diseases in France. Patients were eligible if they were aged at least 18 years with a life expectancy greater than 3 months, had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, Child-Pugh liver function class A or B score of 7 or lower, and locally advanced hepatocellular carcinoma (Barcelona Clinic Liver Cancer [BCLC] stage C), or new hepatocellular carcinoma not eligible for surgical resection, liver transplantation, or thermal ablation after a previously cured hepatocellular carcinoma (cured by surgery or thermoablative therapy), or hepatocellular carcinoma with two unsuccessful rounds of transarterial chemoembolisation...
October 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29105342/optimization-and-evaluation-of-antiparasitic-benzamidobenzoic-acids-as-inhibitors-of-kinetoplastid-hexokinase-1
#6
Daniel P Flaherty, Michael T Harris, Chad E Schroeder, Haaris Khan, Elizabeth Kahney, Amber Hackler, Stephen Patrick, Warren S Weiner, Jeffrey Aube, Elizabeth R Sharlow, James C Morris, Jennifer E Golden
Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of hexokinase activity - a pivotal enzyme in parasite metabolism. A benzamidobenzoic acid hit with modest biochemical inhibition of Trypanosoma brucei hexokinase 1 (TbHK1, IC₅₀ = 9.1 μM), low mammalian cytotoxicity (IMR90, EC₅₀ > 25 μM), and no appreciable activity on whole BSF parasites was optimized to afford a probe with improved TbHK1 potency and, significantly, efficacy against whole BSF parasites (TbHK1, IC₅₀ = 0...
November 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29104436/taxonomy-and-biogeography-without-frontiers-whatsapp-facebook-and-smartphone-digital-photography-let-citizen-scientists-in-more-remote-localities-step-out-of-the-dark
#7
Nano Suprayitno, Raden Pramesa Narakusumo, Thomas von Rintelen, Lars Hendrich, Michael Balke
Background: Taxonomy and biogeography can benefit from citizen scientists. The use of social networking and open access cooperative publishing can easily connect naturalists even in more remote areas with in-country scientists and institutions, as well as those abroad. This enables taxonomic efforts without frontiers and at the same time adequate benefit sharing measures. New information: We present new distribution and habitat data for diving beetles of Bali island, Indonesia, as a proof of concept...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29102726/differential-gene-expression-analysis-in-ageing-muscle-and-drug-discovery-perspectives
#8
REVIEW
Aicha Melouane, Abdelaziz Ghanemi, Simon Aubé, Mayumi Yoshioka, Jonny St-Amand
Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Genomic technologies promise to reshape the research on ageing muscle, exercise response and drug discovery...
November 2, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29102507/occurrence-of-chronic-pelvic-pain-abnormal-uterine-bleeding-and-hysterectomy-post-procedure-among-women-who-have-undergone-female-sterilization-procedures-a-retrospective-claims-analysis-of-commercially-insured-women-in-the-us
#9
Patricia I Carney, Jianying Yao, Jay Lin, Amy Law
STUDY OBJECTIVE: To evaluate the frequency of chronic pelvic pain (CPP), abnormal uterine bleeding (AUB), and hysterectomy following hysteroscopic (HS) and laparoscopic (LS) sterilization in the US DESIGN: Retrospective cohort study (Canadian Task Force II-2) SETTING: Commercially-insured women PATIENTS: Women (18-49) with claims for HS or LS (1/1/2010-12/31/2012) were identified from the MarketScan Commercial database. Women were required to have 6 months of continuous coverage prior to (baseline) and 24 months after (follow-up) the procedure date...
November 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29101389/pirnas-and-aubergine-cooperate-with-wispy-poly-a-polymerase-to-stabilize-mrnas-in-the-germ-plasm
#10
Jérémy Dufourt, Gwénaëlle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cécile Meunier, Stéphanie Pierson, Paul F Harrison, Catherine Papin, Traude H Beilharz, Martine Simonelig
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets maternal mRNAs through incomplete base-pairing with piRNAs and can induce their destabilization in the somatic part of the embryo. Paradoxically, these Aub-dependent unstable mRNAs encode germ cell determinants that are selectively stabilized in the germ plasm...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29082726/-differential-diagnosis-and-management-of-abnormal-uterine-bleeding-in-adolescence
#11
Tiziano Motta, Antonio S Laganà, Gaetano Valenti, Valentina L LA Rosa, Marco Noventa, Amerigo Vitagliano, Benito Chiofalo, Agnese M Rapisarda, Diego Rossetti, Salvatore G Vitale
Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases, including oncological ones. Diagnostic procedures require the acquisition of a full and detailed history, and it is also crucial to obtain as much compliance from the patient as possible...
December 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29078976/abnormal-uterine-bleeding-including-coagulopathies-and-other-menstrual-disorders
#12
REVIEW
Efthimios Deligeoroglou, Vasileios Karountzos
Abnormal Uterine Bleeding (AUB) is a frequent cause of visits to the emergency department and a major reason for concern among adolescents and their families. The most common cause of AUB, in otherwise healthy adolescents, is ovulatory dysfunction, although 5-36% of adolescents who present with heavy menstrual bleeding, have an underlying bleeding disorder (BD). The most common form of BDs is von Willebrand Disease, reflecting 13% of adolescents with AUB. Management of AUB depends on the underlying etiology, the bleeding severity, as well as the need for hospitalization...
October 9, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29057431/is-routine-performance-of-the-uterine-cervix-canal-curettage-prior-to-the-curettage-of-the-uterine-cavity-justified
#13
Szymon Piątek, Jacek Lipa, Monika Górska, Katarzyna Malecha, Grzegorz Panek, Mirosław Wielgoś
OBJECTIVES: Endocervical curettage (ECC) together with the dilatation and curettage of the uterine cavity (D & C) is routinely performed in everyday clinical practice. The aim of this study is to assess the rationale of the performance of ECC prior to D & C in indications other than abnormal uterine bleeding (AUB). MATERIAL AND METHODS: Case histories of 736 patients after ECC performed in the 1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, were analyzed retrospectively, the indications for the procedure - age, menopausal status, parity, procedure operator's experience - as well as the result of the histopathology examination were taken into account...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29048917/a-population-based-study-of-the-prevalence-of-abnormal-uterine-bleeding-and-its-related-factors-among-iranian-reproductive-age-women-an-updated-data
#14
Hadigheh Kazemijaliseh, Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani, Davood Khalili, Farhad Hosseinpanah, Fereidoun Azizi
BACKGROUND: Abnormal uterine bleeding (AUB) is one of the most common gynecologic complaints among reproductive-age women. The purpose of this study was to investigate the prevalence of AUB and its related factors among reproductive age Iranian women. METHODS: A population-based cross-sectional study was conducted on 1393 women aged 15 - 45 years who participated in the Tehran Lipid and Glucose Study in 2009 - 2012. FIGO terminology and previous definitions were used for classification of AUB...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29042845/implementation-of-integrated-service-networks-under-the-quebec-mental-health-reform-facilitators-and-barriers-associated-with-different-territorial-profiles
#15
Marie-Josée Fleury, Guy Grenier, Catherine Vallée, Denise Aubé, Lambert Farand
INTRODUCTION: This study evaluates implementation of the Quebec Mental Health Reform (2005-2015), which promoted the development of integrated service networks, in 11 local service networks organized into four territorial groups according to socio-demographic characteristics and mental health services offered. METHODS: Data were collected from documents concerning networks; structured questionnaires completed by 90 managers and by 16 respondent-psychiatrists; and semi-structured interviews with 102 network stakeholders...
March 10, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29039304/desulfonatronum-parangueonense-sp-nov-a-sulfate-reducing-bacterium-isolated-from-sediment-of-an-alkaline-crater-lake
#16
Maria Fernanda Pérez Bernal, Elcia Margareth Souza Brito, Manon Bartoli, Johanne Aubé, Marie-Laure Fardeau, German Cuevas Rodriguez, Bernard Ollivier, Rémy Guyoneaud, Agnès Hirschler-Réa
Novel Gram-stain-negative, non-spore-forming, vibrio-shaped, anaerobic, alkaliphilic, sulfate-reducing bacteria, designated strains PAR180(T) and PAR190, were isolated from sediments collected at an alkaline crater lake in Guanajuato (Mexico). Strain PAR180(T) grew at temperatures between 15 and 40 °C (optimum 35 °C), and at pH between 8.3 and 10.4 (optimum 9). It was halotolerant, growing with up to 8 % (w/v) NaCl. Lactate, formate, pyruvate and ethanol were used as electron donors in the presence of sulfate and were incompletely oxidized to acetate and CO2...
October 17, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29030484/aubergine-and-pirnas-promote-germline-stem-cell-self-renewal-by-repressing-the-proto-oncogene-cbl
#17
Patricia Rojas-Ríos, Aymeric Chartier, Stéphanie Pierson, Martine Simonelig
PIWI proteins play essential roles in germ cells and stem cell lineages. In Drosophila, Piwi is required in somatic niche cells and germline stem cells (GSCs) to support GSC self-renewal and differentiation. Whether and how other PIWI proteins are involved in GSC biology remains unknown. Here, we show that Aubergine (Aub), another PIWI protein, is intrinsically required in GSCs for their self-renewal and differentiation. Aub needs to be loaded with piRNAs to control GSC self-renewal and acts through direct mRNA regulation...
November 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29021243/zucchini-dependent-pirna-processing-is-triggered-by-recruitment-to-the-cytoplasmic-processing-machinery
#18
Alicia K Rogers, Kathy Situ, Edward M Perkins, Katalin Fejes Toth
The piRNA pathway represses transposable elements in the gonads and thereby plays a vital role in protecting the integrity of germline genomes of animals. Mature piRNAs are processed from longer transcripts, piRNA precursors (pre-piRNAs). In Drosophila, processing of pre-piRNAs is initiated by piRNA-guided Slicer cleavage or the endonuclease Zucchini (Zuc). As Zuc does not have any sequence or structure preferences in vitro, it is not known how piRNA precursors are selected and channeled into the Zuc-dependent processing pathway...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/29016481/auto-regulated-exercise-selection-training-regimen-produces-small-increases-in-lean-body-mass-and-maximal-strength-adaptations-in-strength-trained-individuals
#19
Jacob T Rauch, Carlos Ugrinowitsch, Christopher I Barakat, Michael R Alvarez, David L Brummert, Daniel W Aube, Andrew S Barsuhn, Daniel Hayes, Valmor Tricoli, Eduardo O De Souza
The purpose of this investigation was to compare the effects of auto-regulatory exercise selection (AES) vs. fixed exercise selection (FES) on muscular adaptations in strength-trained individuals. Seventeen males (Mean ± SD; age = 24 ± 5.45 years; height = 180.3 ± 7.54cm, lean body mass [LBM] 66.44 ± 6.59kg; squat and bench press 1RM: body mass ratio 1.87, 1.38 respectively) were randomly assigned into either AES or FES. Both groups trained three times a week for 9 weeks. AES self-selected the exercises for each session, whereas FES was required to perform exercises in a fixed order...
October 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28981728/competition-between-translation-initiation-factor-eif5-and-its-mimic-protein-5mp-determines-non-aug-initiation-rate-genome-wide
#20
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Sarah Gillaspie, Eric Aube, Jagpreet Nanda, Maud Marques, Maika Jangal, Abbey Anderson, Christian Cox, Hiroyuki Hiraishi, Leiming Dong, Hirohide Saito, Chingakham Ranjit Singh, Michael Witcher, Ivan Topisirovic, Shu-Bing Qian, Katsura Asano
In the human genome, translation initiation from non-AUG codons plays an important role in various gene regulation programs. However, mechanisms regulating the non-AUG initiation rate remain poorly understood. Here, we show that the non-AUG initiation rate is nearly consistent under a fixed nucleotide context in various human and insect cells. Yet, it ranges from <1% to nearly 100% compared to AUG translation, depending on surrounding sequences, including Kozak, and possibly additional nucleotide contexts...
November 16, 2017: Nucleic Acids Research
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