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https://www.readbyqxmd.com/read/28420690/identification-of-protein-features-encoded-by-alternative-exons-using-exon-ontology
#1
Léon-Charles Tranchevent, Fabien Aubé, Louis Dulaurier, Clara Benoit-Pilven, Amandine Rey, Arnaud Poret, Emilie Chautard, Hussein Mortada, François-Olivier Desmet, Fatima Zahra Chakrama, Maira Alejandra Moreno-Garcia, Evelyne Goillot, Stéphane Janczarski, Franck Mortreux, Cyril F Bourgeois, Didier Auboeuf
Transcriptomic genome-wide analyses demonstrate massive variation of alternative splicing in many physiological and pathological situations. One major challenge is now to establish the biological contribution of alternative splicing variation in physiological- or pathological-associated cellular phenotypes. Toward this end, we developed a computational approach, named Exon Ontology, based on terms corresponding to well-characterized protein features organized in an ontology tree. Exon Ontology is conceptually similar to Gene Ontology-based approaches but focuses on exon-encoded protein features instead of gene level functional annotations...
April 18, 2017: Genome Research
https://www.readbyqxmd.com/read/28405466/potentially-effective-therapy-of-heavy-menstrual-bleeding-with-an-oestradiol-nomegestrol-acetate-oral-contraceptive-a-pilot-study
#2
Edith Weisberg, Kevin McGeehan, Jane Hangan, Ian S Fraser
BACKGROUND: Heavy menstrual bleeding (HMB) exceeding 80 mL per cycle leads to considerable adverse impact on a woman's iron metabolism, incidence of iron deficiency and anaemia, as well as her functioning in society. The objective of the study is to determine the potential efficacy of a Monophasic oestradiol-17β-nomegestrol acetate (E2/Nomac) combined oral contraceptive pill on measured menstrual blood loss as a pilot study in 12 women with objectively demonstrated HMB (>80 mL per cycle)...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28405119/figo-s-palm-coein-classification-of-abnormal-uterine-bleeding-a-clinico-histopathological-correlation-in-indian-setting
#3
Devanshi Mishra, Shabana Sultan
INTRODUCTION: Abnormal uterine bleeding (AUB) is the commonest menstrual problem during perimenopause. The International Federation of Gynaecology and Obstetrics working group on menstrual disorders has developed a classification system (PALM-COEIN) for causes of the AUB in non-gravid women. The present study was conducted with the aim to study the two components of this system in clinical practice in general and to establish a clinico-pathological correlation of AUB with context of PALM component in particular...
April 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28395852/diagnosis-of-hepatocellular-carcinoma-an-update-on-international-guidelines
#4
C Cassinotto, C Aubé, A Dohan
Imaging is essential for the successful management of patients with or at risk of developing hepatocellular carcinoma (HCC). If ultrasound remains the key screening modality, computed tomography and magnetic resonance imaging (MRI) can play a major role in the characterization and noninvasive diagnosis of nodules in patients at risk of developing HCC. Each technique has succeeded in adapting to the wide histological spectrum of focal liver lesions. In this review, we discuss recent advancements in imaging techniques and evaluation - notably diffusion-weighted imaging, contrast-enhanced ultrasound, and liver-specific MRI contrast agents - as well as their addition to international guidelines and reporting systems such as the Liver imaging reporting and data system (LI-RADS)...
April 5, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28373265/structural-and-functional-evaluation-of-clinically-relevant-inhibitors-of-steroidogenic-cytochrome-p450-17a1-cyp17a1
#5
Elyse M Petrunak, Steven A Rogers, Jeffrey Aube, Emily E Scott
Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form of the only FDA- approved CYP17A1 inhibitor, binds the catalytic heme iron, nonselectively impeding both reactions and ultimately causing undesirable corticosteroid imbalance. Some non-steroidal inhibitors reportedly inhibit the lyase reaction more than the preceding hydroxylase reaction, which would be clinically advantageous, but the mechanism is not understood...
April 3, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28367365/daily-rhythms-of-behavioral-and-hormonal-patterns-in-male-dromedary-camels-housed-in-boxes
#6
Lydiane Aubè, Meriem Fatnassi, Davide Monaco, Touhami Khorchani, Giovanni Michele Lacalandra, Mohamed Hammadi, Barbara Padalino
BACKGROUND: Daily rhythmicity has been observed for a number of hormonal and behavioral variables in mammals. It can be entrained by several external factors, such as light-dark cycle and scheduled feeding. In dromedary camels, daily rhythmicity has been documented only for melatonin secretion and body temperature. In this study, the daily rhythmicity of behavioral repertoire, cortisol and testosterone levels was investigated in captive male camels. METHODS: Six clinically healthy male dromedary camels (Camelus dromedarius) were used...
2017: PeerJ
https://www.readbyqxmd.com/read/28346737/easl-and-aasld-recommendations-for-the-diagnosis-of-hcc-to-the-test-of-daily-practice
#7
Christophe Aubé, Frederic Oberti, Julie Lonjon, Georges Pageaux, Olivier Seror, Giséle N'Kontchou, Agnes Rode, Sylvie Radenne, Christophe Cassinotto, Julien Vergniol, Ivan Bricault, Vincent Leroy, Maxime Ronot, Laurent Castera, Sophie Michalak, Maxime Esvan, Valérie Vilgrain
AIM: To evaluate the diagnostic performance of CT, MRI, and CEUS alone and in combination, for the diagnosis of HCC between 10 and 30 mm, in a large population of cirrhotic patients. PATIENTS AND METHODS: In a multicentre prospective trial, 442 patients have been enrolled. Within a month CEUS, CT and MRI were performed for all patients. A composite algorithm was defined to obtain the more accurate gold standard. RESULTS: 544 nodules in 381 patients have been retained for the performance analysis...
March 27, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28334831/the-pentatricopeptide-repeat-protein-mtsf2-stabilizes-a-nad1-precursor-transcript-and-defines-the-3%C3%AE-end-of-its-5%C3%AE-half-intron
#8
Chuande Wang, Fabien Aubé, Noelya Planchard, Martine Quadrado, Céline Dargel-Graffin, Fabien Nogué, Hakim Mireau
RNA expression in plant mitochondria implies a large number of post-transcriptional events in which transcript processing and stabilization are essential. In this study, we analyzed the function of the Arabidopsis mitochondrial stability factor 2 gene (MTSF2) and show that the encoded pentatricopeptide repeat protein is essential for the accumulation of stable nad1 mRNA. The production of mature nad1 requires the assembly of three independent RNA precursors via two trans-splicing reactions. Genetic analyses revealed that the lack of nad1 in mtsf2 mutants results from the specific destabilization of the nad1 exons 2-3 precursor transcript...
March 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28318358/assessing-abnormal-uterine-bleeding-are-physicians-taking-a-meaningful-clinical-history
#9
Christina Lam, Britta Anderson, Vrishali Lopes, Jay Schulkin, Kristen Matteson
INTRODUCTION: Women with abnormal uterine bleeding (AUB) report significant reductions in quality of life (QOL), which can be attributed in many cases to the fear of embarrassing episodes of bleeding. We performed this study to determine whether or not during clinical encounters physicians addressed the impact of AUB on patient-reported QOL. MATERIALS AND METHODS: Between October 2008 and May 2009, we conducted a cross-sectional study of members of the American College of Obstetricians and Gynecologists...
March 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28297669/molecular-landscape-of-the-ribosome-pre-initiation-complex-during-mrna-scanning-structural-role-for-eif3c-and-its-control-by-eif5
#10
Eiji Obayashi, Rafael E Luna, Takashi Nagata, Pilar Martin-Marcos, Hiroyuki Hiraishi, Chingakham Ranjit Singh, Jan Peter Erzberger, Fan Zhang, Haribabu Arthanari, Jacob Morris, Riccardo Pellarin, Chelsea Moore, Ian Harmon, Evangelos Papadopoulos, Hisashi Yoshida, Mahmoud L Nasr, Satoru Unzai, Brytteny Thompson, Eric Aube, Samantha Hustak, Florian Stengel, Eddie Dagraca, Asokan Ananbandam, Philip Gao, Takeshi Urano, Alan G Hinnebusch, Gerhard Wagner, Katsura Asano
During eukaryotic translation initiation, eIF3 binds the solvent-accessible side of the 40S ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center. This is largely mediated by the N-terminal domain (NTD) of eIF3c, which can be divided into three parts: 3c0, 3c1, and 3c2. The N-terminal part, 3c0, binds eIF5 strongly but only weakly to the ribosome-binding surface of eIF1, whereas 3c1 and 3c2 form a stoichiometric complex with eIF1. 3c1 contacts eIF1 through Arg-53 and Leu-96, while 3c2 faces 40S protein uS15/S13, to anchor eIF1 to the scanning pre-initiation complex (PIC)...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28258453/failure-of-conservative-treatment-of-acute-diverticulitis-with-extradigestive-air
#11
P A Colas, E Duchalais, Q Duplay, V Serra-Maudet, S Kanane, C Ridereau-Zins, E Lermite, C Aubé, A Hamy, A Venara
BACKGROUND: Medical management for perforated diverticulitis without abscess or peritonitis (PDwAP) has a success rate of 40-70%. Identifying patients with a risk of medical treatment failure would improve outcomes. The aim of this study was to identify the risk factors for failure of medical treatment in patients admitted with PDwAP. METHODS: This multicenter retrospective observational study included all consecutive patients admitted for PDwAP and not surgically treated over a 7-year period...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28256451/towards-low-dimensional-hole-systems-in-be-doped-gaas-nanowires
#12
A R Ullah, J G Gluschke, P Krogstrup, C B Sørensen, J Nygård, A P Micolich
GaAs was central to the development of quantum devices but is rarely used for nanowire-based quantum devices with InAs, InSb and SiGe instead taking the leading role. p-type GaAs nanowires offer a path to studying strongly confined 0D and 1D hole systems with strong spin-orbit effects, motivating our development of nanowire transistors featuring Be-doped p-type GaAs nanowires, AuBe alloy contacts and patterned local gate electrodes towards making nanowire-based quantum hole devices. We report on nanowire transistors with traditional substrate back-gates and EBL-defined metal/oxide top-gates produced using GaAs nanowires with three different Be-doping densities and various AuBe contact processing recipes...
March 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28254193/ct-findings-of-complications-after-abdominal-wall-repair-with-prosthetic-mesh
#13
REVIEW
M Lacour, C Ridereau Zins, C Casa, A Venara, V Cartier, S Yahya, J Barbieux, C Aubé
Postoperative complications following prosthetic mesh repair are relatively rare and depend on the type and location of prosthetic mesh. They include abscess, hematoma, seroma, fistula, bowel obstruction, mesh retraction, granuloma and recurrent hernia. Computed tomography (CT) is the imaging examination of choice for the diagnosis of such complications. This pictorial review illustrates the CT presentation of the most and less common postoperative complications following prosthetic mesh repair of the abdominal wall...
February 18, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28246495/accuracy-of-transvaginal-ultrasonography-compared-to-endometrial-biopsy-for-the-etiological-diagnosis-of-abnormal-perimenopausal-bleeding
#14
Renata Nicula, Doru Diculescu, Codruţa Claudia Lencu, Răzvan Ciortea, Carmen Elena Bucuri, Ioana Adriana Oltean, Ioana Alexandra Trif, Dan Mihu
BACKGROUND AND AIMS: Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management. METHOD: The study included 103 patients aged between 41.5-55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39)...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28238590/the-current-status-of-hormonal-therapies-for-heavy-menstrual-bleeding
#15
REVIEW
Oskari Heikinheimo, Ian Fraser
Hormonal treatment of abnormal uterine bleeding (AUB), especially bleeding related to endometrial causes (AUB-E), ovulatory dysfunction (AUB-O) and coagulopathy (AUB-C), and to some extent, uterine leiomyomas and adenomyosis, has become the first-line evidence-based management strategy during recent years. Hormonal treatment of heavy menstrual bleeding (HMB) is also endorsed as the first line of treatment in several international guidelines. In the present article, we review the efficacy of the commonly used and widely available hormonal treatments of AUB-O, AUB-E and AUB-C...
January 21, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28215550/evaluation-of-unenhanced-post-mortem-computed-tomography-to-detect-chest-injuries-in-violent-death
#16
I Sifaoui, C Nedelcu, G Beltran, V Dupont, J Lebigot, A Gaudin, C Ridereau Zins, C Rouge Maillard, C Aubé
PURPOSE: The aim of this study was to assess the performances of unenhanced post-mortem computed tomography (CT) to detect thoracic injuries in violent death. MATERIALS AND METHODS: Retrospectively, we conducted a review of unenhanced CT scans of 67 victims of violent deaths with thoracic injuries and compared CT findings with the results of clinical autopsy. Our gold standard was a comparison of CT scans with autopsy discussed in a monthly forensic radiology multidisciplinary team meeting (MDTM)...
February 16, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28215253/early-features-associated-with-the-neurocognitive-development-at-36-months-of-age-the-aube-study
#17
Sabine Plancoulaine, Camille Stagnara, Sophie Flori, Flora Bat-Pitault, Jian-Sheng Lin, Hugues Patural, Patricia Franco
BACKGROUND: Few studies on the relations between sleep quantity and/or quality and cognition have been conducted among preschoolers from healthy general population. We aimed at identifying, among 36 months old children, early factors associated with intelligence quotient (IQ) estimated through the Weschler Preschool and Primary Scale Intelligence-III test and its indicators: Full-Scale-, Verbal- and Performance-IQs and their subscale scores. METHODS: We included 194 children from the French birth cohort AuBE with both available Weschler Preschool and Primary Scale Intelligence-III scores at three years and sleep data...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28164327/liver-fibrosis-diagnosis-by-blood-test-and-elastography-in-chronic-hepatitis-c-agreement-or-combination
#18
P Calès, J Boursier, J Lebigot, V de Ledinghen, C Aubé, I Hubert, F Oberti
BACKGROUND: In chronic hepatitis C, the European Association for the Study of the Liver - Asociacion Latinoamericana para el Estudio del Higado recommends performing transient elastography and a blood test to diagnose significant fibrosis; test concordance confirms diagnosis. AIM: To validate this rule and improve it by combining a blood test, FibroMeter (virus second generation, Echosens, Paris, France) and transient elastography (constitutive tests) into a single combined test, as suggested by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America...
February 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28163815/a-bulbar-artery-pseudoaneurysm-following-traumatic-urethral-catheterization
#19
Mathieu Bettez, Melanie Aubé, Mohamed El Sherbiny, Tatiana Cabrera, Roman Jednak
Traumatic urethral catheterization may result in a number of serious complications. A rare occurrence is the development of a urethral pseudoaneurysm. We report the case of a 13-year-old male who required placement of a Foley catheter for an orthopedic surgical procedure. The Foley was misplaced in the bulbourethra, resulting in the development of a bulbar artery pseudoaneurysm. Profuse bleeding via the urethra was noted after removal of the catheter, and the patient experienced severe intermittent hematuria during the postoperative period...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28162601/-361-a-novel-g-protein-biased-kappa-opioid-that-displays-analgesic-but-not-dysphoric-actions-in-the-rat
#20
T Martin, S Kim, J Rose, S Jones, J Aubé, L Bohn
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
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