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https://www.readbyqxmd.com/read/27914969/endometrial-polyps-and-abnormal-uterine-bleeding-aub-p-what-is-the-relationship-how-are-they-diagnosed-and-how-are-they-treated
#1
REVIEW
T Justin Clark, Helen Stevenson
The diagnosis and treatment of endometrial polyps will be familiar to most gynaecologists. However, the aetiology and natural history of these focal intrauterine lesions are yet to be elucidated. This lack of clarity is also true with regard to their clinical significance; whilst endometrial polyps are highly prevalent in all types of abnormal uterine bleeding (AUB), they are also commonly found in women without AUB. These controversies will be discussed along with current thoughts on the diagnosis and treatment of endometrial polyps...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27903446/polycystic-ovary-syndrome-an-under-recognized-cause-of-abnormal-uterine-bleeding-in-adolescents-admitted-to-a-children-s-hospital
#2
Sofya Maslyanskaya, Hina J Talib, Jennifer L Northridge, Amanda M Jacobs, Chanelle Coble, Susan M Coupey
STUDY OBJECTIVE: To evaluate whether ovulatory dysfunction due to polycystic ovary syndrome (PCOS) is a common underlying etiology of abnormal uterine bleeding (AUB) in adolescents requiring hospitalization and to explore etiology, treatment and complications of AUB with severe anemia in adolescents. DESIGN: We identified females aged 8 to 20 years admitted to a children's hospital for treatment of AUB from January 2000 to December 2014. Our hospital protocol advises hormonal testing for PCOS and other disorders prior to treatment for AUB...
November 26, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27899527/biased-agonists-of-the-kappa-opioid-receptor-suppress-pain-and-itch-without-causing-sedation-or-dysphoria
#3
Tarsis F Brust, Jenny Morgenweck, Susy A Kim, Jamie H Rose, Jason L Locke, Cullen L Schmid, Lei Zhou, Edward L Stahl, Michael D Cameron, Sarah M Scarry, Jeffrey Aubé, Sara R Jones, Thomas J Martin, Laura M Bohn
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, they do produce dysphoria and sedation, side effects that have precluded their clinical development as therapeutics. KOR signaling can be fine-tuned to preferentially activate certain pathways over others, such that agonists can bias signaling so that the receptor signals through G proteins rather than other effectors such as βarrestin2...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27868289/determinants-of-health-related-quality-of-life-in-anti-mag-neuropathy-a-cross-sectional-multicentre-european-study
#4
Emilien Delmont, Fu Liong Hiew, Julien Cassereau, Anne-Catherine Aubé-Nathier, Aude-Marie Grapperon, Shahram Attarian, Yusuf A Rajabally
Our objective was to assess determinants of quality of life (QoL) in anti-myelin associated glycoprotein antibody (MAG) neuropathy. The SF-36 questionnaire was assessed in 55 patients, from Marseille, Angers (France) and Birmingham (United Kingdom). Routine clinical evaluations included MRC sum score, INCAT sensory score, Inflammatory Rasch-built Overall Disability Score (I-RODS), ataxia score, Jamar grip dynamometry, timed 10 m-walk, Neuropathic Pain Symptom Inventory (NPSI) score, and Fatigue Severity Score (FSS)...
November 21, 2016: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/27851737/genetic-and-mechanistic-diversity-of-pirna-3-end-formation
#5
Rippei Hayashi, Jakob Schnabl, Dominik Handler, Fabio Mohn, Stefan L Ameres, Julius Brennecke
Small regulatory RNAs guide Argonaute (Ago) proteins in a sequence-specific manner to their targets and therefore have important roles in eukaryotic gene silencing. Of the three small RNA classes, microRNAs and short interfering RNAs are processed from double-stranded precursors into defined 21- to 23-mers by Dicer, an endoribonuclease with intrinsic ruler function. PIWI-interacting RNAs (piRNAs)-the 22-30-nt-long guides for PIWI-clade Ago proteins that silence transposons in animal gonads-are generated independently of Dicer from single-stranded precursors...
November 16, 2016: Nature
https://www.readbyqxmd.com/read/27836285/practical-aspects-of-the-two-figo-systems-for-management-of-abnormal-uterine-bleeding-in-the-reproductive-years
#6
REVIEW
Malcolm G Munro
The FIGO systems defining the nomenclature and symptoms of abnormal uterine bleeding (AUB) in the reproductive years (System 1) and the PALM-COEIN classification of causes of AUB (System 2) are designed to facilitate research, education, and the provision of optimum clinical care for affected women. Development of these systems has been the result of a collaborative effort of experts in bench and translational and clinical research from six continents aided by a spectrum of representatives from relevant medical societies, journals, and regulatory bodies...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27818130/structured-imaging-technique-in-the-gynecologic-office-for-the-diagnosis-of-abnormal-uterine-bleeding
#7
REVIEW
Margit Dueholm, Ina Marie D Hjorth
: The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27810281/adenomyosis-and-abnormal-uterine-bleeding-aub-a-pathogenesis-diagnosis-and-management
#8
REVIEW
Jason A Abbott
The complex pathogenesis and variable presentation of adenomyosis make it one of the most difficult of the FIGO PALM-COIEN abnormal uterine bleeding group to diagnose and treat. Basic clinical parameters such as prevalence are difficult to accurately assess because histological confirmation is usually employed; however, because of the access to and accuracy and utilization of transvaginal ultrasound and other advanced imaging techniques such as MRI, noninvasive diagnosis is recognized to be highly accurate...
September 30, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27796406/-prognostic-assessment-in-private-healthcare-insurance-part%C3%A2-2-risk-supplement-for-accidental-endoprostheses
#9
H-T Klemm, A Naumann, G Hofmann, G Spahn
After examining the causes of an accident the medical expert working in the area of private health care insurance under the general accident insurance (AUB) sample conditions must ascertain incapacity within a period of time that has been contractually agreed between the parties involved. In addition, this must also state their position on the question as to whether there may exist any circumstances up to the latest possible point in time in insurance terms that would comprise an adequate prognosis of a future change in the long-term condition...
October 28, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27796405/-prognostic-assessment-in-private-healthcare-insurance-part-1-risk-of-osteoarthritis
#10
H-T Klemm, A Naumann, G Hofmann, G Spahn
After examining the cause of an accident the medical expert working in the area of private health care insurance under the general accident insurance (AUB) sample conditions must ascertain incapacity within a period of time that has been contractually agreed upon between the parties involved. In addition, this person must also state their position on the question as to whether there may exist any circumstances up to the latest possible point in time in insurance terms that would comprise an adequate prognosis of a future change in the long-term condition...
October 28, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27789612/kc167-a-widely-used-drosophila-cell-line-contains-an-active-primary-pirna-pathway
#11
Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Zissimos Mourelatos
PIWI family proteins bind to small RNAs known as PIWI-interacting RNAs (piRNAs) and play essential roles in the germline by silencing transposons and by promoting germ cell specification and function. Cell lines that endogenously express piRNAs and PIWI proteins are an invaluable complement to whole-organism studies as they facilitate molecular and biochemical investigations of piRNAs. Here we report that the widely used Kc167 cell line, derived from Drosophila melanogaster embryos, expresses piRNAs that are loaded to Aub and Piwi...
October 27, 2016: RNA
https://www.readbyqxmd.com/read/27787478/dysfunctional-uterine-bleeding-as-an-early-sign-of-polycystic-ovary-syndrome-during-adolescence-an-update
#12
Efthimios Deligeoroglou, Vasileios Karountzos
AIM: Abnormal Uterine Bleeding (AUB) is a frequent reason for concern between adolescents. The most common cause of AUB in these girls, when other pathologies have been excluded, is Dysfunctional Uterine Bleeding (DUB). The aim of this review is to assess the role of DUB as an early symptom of Polycystic Ovarian Syndrome (PCOS) diagnosis later in life. METHODS: Review of the literature, using Pubmed and Medline as primary databases, regarding the correlation between DUB cases early after menarche and PCOS diagnosis in the future...
October 27, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27784616/the-role-of-leiomyomas-in-the-genesis-of-abnormal-uterine-bleeding-aub
#13
REVIEW
Ricardo Bassil Lasmar, Bernardo Portugal Lasmar
Abnormal uterine bleeding (AUB) is the major complaint in approximately one-third of gynecological visits in premenopausal women, and in >70% of appointments of perimenopausal and postmenopausal women. Uterine myoma is one of the main causes of AUB during menacme, especially when it is submucosal. The association of myoma and AUB may be related to several factors, from local alterations of angiogenic and vasoactive substances to changes in uterine contractility. The objective of this paper is to show the different associations of myoma and AUB...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27780345/radiofrequency-in-the-management-of-colorectal-liver-metastases-a-10-year-experience-at-a-single-center
#14
Sandra Aissou, Victoire Cartier, Antoine Hamy, Fleur Plumereau, Christophe Aube, Emilie Lermite
BACKGROUND: Liver resection is the curative treatment for patients with colorectal liver metastases (CRLMs), with five-year survival rates of 30-50%. Radiofrequency ablation (RFA) is a local and useful alternative for patients with non-resectable CRLMs to obtain complete tumor clearance. The aim of this study was to analyze survival rates with this local treatment. MATERIALS AND METHODS: All patients who underwent RFA and resection or RFA alone for unresectable CRLMs between 2001 and 2012 were included in a retrospective study...
October 26, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27759449/the-molecular-and-genetic-aspects-of-adolescent-girls-anomalous-uterine-bleeding-the-role-of-endothelial-dysfunction-syndrome
#15
O A Melkozerova, N V Bashmakova, E V Volkova, T B Tretyakova, P B Tsyvian
The objective of the study is to assess NOS3 and ESR1 gene polymorphism in adolescent girls born with low birth weight (LBW) and suffered by anomalous uterine bleeding (AUB). A total 95 adolescent girls were studied including 32 born with LBW and AUB; 36 girls with normal birth weight and AUB; and 27 healthy girls. Single allele gene polymorphism NOS3 786T > C, 894G > T, ESR1 351A > G and 397T > C was studied. The existence of polymorphous allele С gene NOS3 786Т > С (for homozygote OR = 2...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27756297/implementation-of-the-quebec-mental-health-reform-2005-2015
#16
Marie-Josée Fleury, Guy Grenier, Catherine Vallée, Denise Aubé, Lambert Farand, Jean-Marie Bamvita, Geneviève Cyr
BACKGROUND: This study evaluates implementation of the Quebec Mental Health (MH) Reform (2005-2015) which aimed to improve accessibility, quality and continuity of care by developing primary care and optimizing integrated service networks. Implementation of MH primary care teams, clinical strategies for consolidating primary care, integration strategies to improve collaboration between primary care and specialized services, and facilitators and barriers related to these measures were examined...
October 18, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27737575/the-remarkable-change-in-euro-american-cranial-shape-and-size
#17
Richard L Jantz, Lee Meadows Jantz
Secular changes in stature, weight, or other components of the body that can be obtained from historical records have been extensively studied. Cranial change has been central to anthropology for more than a century, but the focus has normally been on change measured in centuries or millennia. Cranial change measured in decades, normally considered to result from plastic response to the environment, has been less studied. This article reports on change in cranial vault dimensions in white Americans. Variables were glabello-occipital length (GOL), basion-bregma height (BBH), basion-nasion length (BNL), maximum cranial breadth (XCB), and biauricular breadth (AUB)...
January 2016: Human Biology
https://www.readbyqxmd.com/read/27721027/the-utility-of-routine-ultrasound-in-the-diagnosis-and-management-of-adolescents-with-abnormal-uterine-bleeding
#18
Yael Pecchioli, Lamide Oyewumi, Lisa M Allen, Sari Kives
STUDY OBJECTIVE: Despite the fact that most cases of abnormal uterine bleeding (AUB) in adolescence are due to an immature hypothalamic-pituitary-ovarian axis (HPO), the current approach to investigating adolescents presenting with AUB often includes pelvic ultrasound to exclude rare structural causes. The aim of this study was to determine whether an ultrasound ordered for the investigation of AUB in adolescents detects any significant anatomic pathology or alters diagnosis and management...
October 6, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27710874/hyperfuctioning-insular-thyroid-carcinoma-a-rare-case-report
#19
Abdulwahid M Salih, F H Kakamad, Han Aube
INTRODUCTION: Insular carcinoma of thyroid (ICT) is a rare pattern of thyroid tumor. Being hyperfunctioning makes the condition rarer. Here we reported a case of ICT associated with hyperthyroidism. CASE REPORT: A 65-year-old female presented with neck mass for 4 years. She had symptoms of thyrotoxicosis and received antithyroid treatment. She was referred for surgical management. She had multiple, non tender, mobile masses in the neck. Ultrasound showed midline multiple heterogenous mass lesions with multiple lymph nodes in right side of the neck largest one measuring 2×2cm...
October 1, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27651654/the-effectiveness-of-levonorgestrel-releasing-intrauterine-system-in-the-treatment-of-heavy-menstrual-bleeding
#20
Georgy Joy Eralil
OBJECTIVE: Levonorgestrel-releasing intrauterine system (LNG-IUS) has been shown to be an effective treatment for patients with abnormal uterine bleeding (AUB) in many Western studies. The purpose of study was to examine the effectiveness of LNG-IUS in the treatment of Indian women with AUB. METHODS: We conducted a retrospective observational study of 70 women diagnosed with AUB and treated with LNG-IUS insertion between February 2010 and 2014 at the Department of Gynecology of Sree Narayana Institute of Medical Sciences...
October 2016: Journal of Obstetrics and Gynaecology of India
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