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https://www.readbyqxmd.com/read/29288653/long-term-outcomes-after-elective-sterilization-procedures-a-comparative-retrospective-cohort-study-of-medicaid-patients
#1
Rachel Steward, Patricia Carney, Amy Law, Lin Xie, Yuexi Wang, Huseyin Yuce
OBJECTIVES: Compare the long-term outcomes, including hysterectomy, chronic pelvic pain (CPP), and abnormal uterine bleeding (AUB) in women post-hysteroscopic sterilization (HS) and laparoscopic tubal ligation (TL) in the Medicaid population. STUDY DESIGN: Retrospective observational cohort analysis using data from the US Medicaid Analytic Extracts (MAX) Encounters database. Women aged 18 to 49years with at least one claim for HS (n=3929) or TL (n=10,875) between July 1, 2009, through December 31, 2010 were included...
December 27, 2017: Contraception
https://www.readbyqxmd.com/read/29281854/macrotrabecular-massive-hepatocellular-carcinoma-a-distinctive-histological-subtype-with-clinical-relevance
#2
Marianne Ziol, Nicolas Poté, Giuliana Amaddeo, Alexis Laurent, Jean-Charles Nault, Frédéric Oberti, Charlotte Costentin, Sophie Michalak, Mohamed Bouattour, Claire Francoz, Georges Philippe Pageaux, Jeanne Ramos, Thomas Decaens, Alain Luciani, Boris Guiu, Valérie Vilgrain, Christophe Aubé, Jonathan Derman, Cécile Charpy, Jessica Zucman-Rossi, Nathalie Barget, Olivier Seror, Nathalie Ganne-Carrié, Valérie Paradis, Julien Calderaro
We recently identified a novel histological subtype of hepatocellular carcinoma, designated as "macrotrabecular-massive" (MTM-HCC) and associated with specific molecular features. In order to assess the clinical relevance of this novel variant, we aimed to investigate its prognostic value in two large series of patients with HCC treated either by surgical resection or radiofrequency ablation (RFA). We retrospectively included 237 HCC surgical samples and 284 HCC liver biopsies from patients treated by surgical resection and RFA, respectively...
December 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29278721/the-pax-protein-eyegone-eyg-interacts-with-the-pi-rna-component-aubergine-aub-and-controls-egg-chamber-development-in-drosophila
#3
David Blom-Dahl, Natalia Azpiazu
The eyegone (eyg) gene encodes Eyg, a transcription factor of the Pax family with multiple roles during Drosophila development. Eyg has been shown to be nuclear in the cells where it functions. In this report we describe a new functional cytoplasmic distribution of Eyg during egg chamber development in the female ovarioles. The protein is present from the germarium until stage 10 of cyst development. The majority of egg chambers that develop in the absence of Eyg arrest their development before stage 10, show augmented levels of the telomeric retro-transposon TART-A and low levels of heterochromatin marks in the oocyte nucleus...
December 23, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29274407/comparison-of-the-accuracy-of-aasld-and-li-rads-criteria-for-the-non-invasive-diagnosis-of-hcc-smaller-than-3-cm
#4
Maxime Ronot, Olivia Fouque, Maxime Esvan, Jérome Lebigot, Christophe Aubé, Valérie Vilgrain
BACKGROUND AND AIMS: To prospectively compare the diagnostic accuracy of the AASLD and LI-RADS v2014 criteria for the non-invasive diagnosis of small HCC, and to evaluate the diagnostic value of ancillary features used in the LI-RADS criteria. Between April 2009 and April 2012, patients with cirrhosis and one to three 10-30mm nodules were enrolled and underwent CT and MR imaging. The diagnostic accuracy of both the AASLD and the LI-RADS criteria were determined based on their sensitivity, specificity, positive (PPV) and negative predictive values (NPV)...
December 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29260281/uncommon-evolutions-and-complications-of-common-benign-liver-lesions
#5
REVIEW
Federica Vernuccio, Maxime Ronot, Marco Dioguardi Burgio, Jérôme Lebigot, Wassim Allaham, Christophe Aubé, Giuseppe Brancatelli, Valérie Vilgrain
Frequently encountered on abdominal imaging studies, the majority of common benign liver lesions are asymptomatic, confidently diagnosed by imaging, and do not require further workup, follow-up, or treatment. The increasing use of multimodality liver imaging, has allowed the recognition of uncommon evolutions of common benign liver lesions such as size changes, fibrotic regression, and content and vascularization changes, and their complications such as rupture, hemorrhage, thrombosis, extrinsic compression, and malignancy...
December 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29232725/value-of-contrast-enhanced-ultrasound-quantification-criteria-for-identifying-patients-not-responding-to-bevacizumab-based-therapy-for-colorectal-liver-metastases
#6
François Tranquart, Paul-Armand Dujardin, Olivier Bouché, Claude Marcus, Christophe Borg, Philippe Manzoni, Jean-Yves Douillard, Catherine Labbe-Devilliers, Eric Terrebonne, Denis Smith, Herve Trillaud, Olivier Capitain, Cristophe Aubé, Jean-Philippe Spano, Olivier Lucidarme, Aurélie Ferru, Jean-Pierre Tasu, Sylvain Manfredi, Aurore Bleuzen, Julie Léger, Thierry Lecomte
Purpose To evaluate changes in tumor vascularization parameters based on contrast-enhanced ultrasound (CEUS) quantification criteria of at least one visible liver metastasis as an early predictor of non-response to chemotherapy, including bevacizumab for colorectal cancer (CRC) liver metastases. Materials and Methods This multicenter prospective study included patients who received first-line bevacizumab-based chemotherapy. Tumor enhancement measured using CEUS within one liver metastasis and in relation to the surrounding healthy liver was quantified within 8 days before the first infusion of bevacizumab (E0), 24 hours after the end of the first infusion of bevacizumab (E1), in the 24 hours before the 2nd and 3 rd infusion of bevacizumab on day 15 (E2) and day 30 (E3), respectively, and after 2 months of treatment (E4)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29139552/critical-evaluation-of-the-palm-coein-classification-system-among-women-with-abnormal-uterine-bleeding-in-low-resource-settings
#7
Divya Shubham, Anjali S Kawthalkar
OBJECTIVE: To assess the feasibility of the PALM-COEIN system for the classification of abnormal uterine bleeding (AUB) in low-resource settings and to suggest modifications. METHODS: A prospective study was conducted among women with AUB who were admitted to the gynecology ward of a tertiary care hospital and research center in central India between November 2014 and October 2016. All patients were managed as per department protocols. The causes of AUB were classified before treatment using the PALM-COEIN system (classification I) and on the basis of the histopathology reports of the hysterectomy specimens (classification II); the results were compared using classification II as the gold standard...
November 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29139384/-seronegative-myasthenia-gravis
#8
Oana Catar, Anne-Catherine Aubé-Nathier, Aleksandra Nadaj-Pakleza
No abstract text is available yet for this article.
November 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29128205/endometrial-ablation
#9
REVIEW
Malcolm G Munro
Endometrial ablation (EA) includes a spectrum of procedures performed with or without hysteroscopic direction, designed to destroy the endometrium for the treatment of the symptom of heavy menstrual bleeding (HMB) secondary to a spectrum of causes, but most commonly those that are endometrial in origin (AUB-E) or ovulatory disorders (AUB-O). Resectoscopic endometrial ablation (REA) is often mistakenly referred to as the "first generation" technique, while proprietary devices that do not use the resectoscope (nonresectoscopic EA or NREA) are often misperceived as "second generation" devices...
October 20, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29113655/laparoscopic-partial-nephrectomy-following-tumor-embolization-in-a-hybrid-room-feasibility-and-clinical-outcomes
#10
Paul Panayotopoulos, Antoine Bouvier, Louis Besnier, Marie Christine Rousselet, Cosmina Nedelcu, Nathalie Baize, Laurent Beydon, Christophe Aubé, Abdel-Rahmène Azzouzi, Pierre Bigot
PURPOSE: In order to limit ischemia and operative bleeding during and after partial nephrectomy we developed a clampless laparoscopic technique, in a hybrid operating room, immediately after super-selective arterial embolization of the renal tumor. We evaluated feasibility and morbidity of this new approach of zero ischemia in partial nephrectomy. METHODS: We included prospectively 50 consecutive patients treated in a hybrid operating room by this new technique for a localized renal tumor in a university hospital between May 2015 and January 2017...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29107679/efficacy-and-safety-of-selective-internal-radiotherapy-with-yttrium-90-resin-microspheres-compared-with-sorafenib-in-locally-advanced-and-inoperable-hepatocellular-carcinoma-sarah-an-open-label-randomised-controlled-phase-3-trial
#11
Valérie Vilgrain, Helena Pereira, Eric Assenat, Boris Guiu, Alina Diana Ilonca, Georges-Philippe Pageaux, Annie Sibert, Mohamed Bouattour, Rachida Lebtahi, Wassim Allaham, Hélène Barraud, Valérie Laurent, Elodie Mathias, Jean-Pierre Bronowicki, Jean-Pierre Tasu, Rémy Perdrisot, Christine Silvain, René Gerolami, Olivier Mundler, Jean-Francois Seitz, Vincent Vidal, Christophe Aubé, Frédéric Oberti, Olivier Couturier, Isabelle Brenot-Rossi, Jean-Luc Raoul, Anthony Sarran, Charlotte Costentin, Emmanuel Itti, Alain Luciani, René Adam, Maïté Lewin, Didier Samuel, Maxime Ronot, Aurelia Dinut, Laurent Castera, Gilles Chatellier
BACKGROUND: Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma. We aimed to compare the efficacy and safety of sorafenib to that of selective internal radiotherapy (SIRT) with yttrium-90 ((90)Y) resin microspheres in patients with hepatocellular carcinoma. METHODS: SARAH was a multicentre, open-label, randomised, controlled, investigator-initiated, phase 3 trial done at 25 centres specialising in liver diseases in France. Patients were eligible if they were aged at least 18 years with a life expectancy greater than 3 months, had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, Child-Pugh liver function class A or B score of 7 or lower, and locally advanced hepatocellular carcinoma (Barcelona Clinic Liver Cancer [BCLC] stage C), or new hepatocellular carcinoma not eligible for surgical resection, liver transplantation, or thermal ablation after a previously cured hepatocellular carcinoma (cured by surgery or thermoablative therapy), or hepatocellular carcinoma with two unsuccessful rounds of transarterial chemoembolisation...
October 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29105342/optimization-and-evaluation-of-antiparasitic-benzamidobenzoic-acids-as-inhibitors-of-kinetoplastid-hexokinase-1
#12
Daniel P Flaherty, Michael T Harris, Chad E Schroeder, Haaris Khan, Elizabeth Kahney, Amber Hackler, Stephen Patrick, Warren S Weiner, Jeffrey Aube, Elizabeth R Sharlow, James C Morris, Jennifer E Golden
Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of hexokinase activity - a pivotal enzyme in parasite metabolism. A benzamidobenzoic acid hit with modest biochemical inhibition of Trypanosoma brucei hexokinase 1 (TbHK1, IC₅₀ = 9.1 μM), low mammalian cytotoxicity (IMR90, EC₅₀ > 25 μM), and no appreciable activity on whole BSF parasites was optimized to afford a probe with improved TbHK1 potency and, significantly, efficacy against whole BSF parasites (TbHK1, IC₅₀ = 0...
November 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29104436/taxonomy-and-biogeography-without-frontiers-whatsapp-facebook-and-smartphone-digital-photography-let-citizen-scientists-in-more-remote-localities-step-out-of-the-dark
#13
Nano Suprayitno, Raden Pramesa Narakusumo, Thomas von Rintelen, Lars Hendrich, Michael Balke
Background: Taxonomy and biogeography can benefit from citizen scientists. The use of social networking and open access cooperative publishing can easily connect naturalists even in more remote areas with in-country scientists and institutions, as well as those abroad. This enables taxonomic efforts without frontiers and at the same time adequate benefit sharing measures. New information: We present new distribution and habitat data for diving beetles of Bali island, Indonesia, as a proof of concept...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29102726/differential-gene-expression-analysis-in-ageing-muscle-and-drug-discovery-perspectives
#14
REVIEW
Aicha Melouane, Abdelaziz Ghanemi, Simon Aubé, Mayumi Yoshioka, Jonny St-Amand
Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Genomic technologies promise to reshape the research on ageing muscle, exercise response and drug discovery...
November 2, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29102507/occurrence-of-chronic-pelvic-pain-abnormal-uterine-bleeding-and-hysterectomy-post-procedure-among-women-who-have-undergone-female-sterilization-procedures-a-retrospective-claims-analysis-of-commercially-insured-women-in-the-us
#15
Patricia I Carney, Jianying Yao, Jay Lin, Amy Law
STUDY OBJECTIVE: To evaluate the frequency of chronic pelvic pain (CPP), abnormal uterine bleeding (AUB), and hysterectomy following hysteroscopic (HS) and laparoscopic (LS) sterilization in the US DESIGN: Retrospective cohort study (Canadian Task Force II-2) SETTING: Commercially-insured women PATIENTS: Women (18-49) with claims for HS or LS (1/1/2010-12/31/2012) were identified from the MarketScan Commercial database. Women were required to have 6 months of continuous coverage prior to (baseline) and 24 months after (follow-up) the procedure date...
November 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29101389/pirnas-and-aubergine-cooperate-with-wispy-poly-a-polymerase-to-stabilize-mrnas-in-the-germ-plasm
#16
Jérémy Dufourt, Gwénaëlle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cécile Meunier, Stéphanie Pierson, Paul F Harrison, Catherine Papin, Traude H Beilharz, Martine Simonelig
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets maternal mRNAs through incomplete base-pairing with piRNAs and can induce their destabilization in the somatic part of the embryo. Paradoxically, these Aub-dependent unstable mRNAs encode germ cell determinants that are selectively stabilized in the germ plasm...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29082726/-differential-diagnosis-and-management-of-abnormal-uterine-bleeding-in-adolescence
#17
Tiziano Motta, Antonio S Laganà, Gaetano Valenti, Valentina L LA Rosa, Marco Noventa, Amerigo Vitagliano, Benito Chiofalo, Agnese M Rapisarda, Diego Rossetti, Salvatore G Vitale
Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases, including oncological ones. Diagnostic procedures require the acquisition of a full and detailed history, and it is also crucial to obtain as much compliance from the patient as possible...
December 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29078976/abnormal-uterine-bleeding-including-coagulopathies-and-other-menstrual-disorders
#18
REVIEW
Efthimios Deligeoroglou, Vasileios Karountzos
Abnormal Uterine Bleeding (AUB) is a frequent cause of visits to the emergency department and a major reason for concern among adolescents and their families. The most common cause of AUB, in otherwise healthy adolescents, is ovulatory dysfunction, although 5-36% of adolescents who present with heavy menstrual bleeding, have an underlying bleeding disorder (BD). The most common form of BDs is von Willebrand Disease, reflecting 13% of adolescents with AUB. Management of AUB depends on the underlying etiology, the bleeding severity, as well as the need for hospitalization...
October 9, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29057431/is-routine-performance-of-the-uterine-cervix-canal-curettage-prior-to-the-curettage-of-the-uterine-cavity-justified
#19
Szymon Piątek, Jacek Lipa, Monika Górska, Katarzyna Malecha, Grzegorz Panek, Mirosław Wielgoś
OBJECTIVES: Endocervical curettage (ECC) together with the dilatation and curettage of the uterine cavity (D & C) is routinely performed in everyday clinical practice. The aim of this study is to assess the rationale of the performance of ECC prior to D & C in indications other than abnormal uterine bleeding (AUB). MATERIAL AND METHODS: Case histories of 736 patients after ECC performed in the 1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, were analyzed retrospectively, the indications for the procedure - age, menopausal status, parity, procedure operator's experience - as well as the result of the histopathology examination were taken into account...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29048917/a-population-based-study-of-the-prevalence-of-abnormal-uterine-bleeding-and-its-related-factors-among-iranian-reproductive-age-women-an-updated-data
#20
Hadigheh Kazemijaliseh, Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani, Davood Khalili, Farhad Hosseinpanah, Fereidoun Azizi
BACKGROUND: Abnormal uterine bleeding (AUB) is one of the most common gynecologic complaints among reproductive-age women. The purpose of this study was to investigate the prevalence of AUB and its related factors among reproductive age Iranian women. METHODS: A population-based cross-sectional study was conducted on 1393 women aged 15 - 45 years who participated in the Tehran Lipid and Glucose Study in 2009 - 2012. FIGO terminology and previous definitions were used for classification of AUB...
September 2017: Archives of Iranian Medicine
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