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https://www.readbyqxmd.com/read/28796898/comparison-of-the-levonorgestrel-releasing-intrauterine-system-hysterectomy-and-endometrial-ablation-for-heavy-menstrual-bleeding-in-a-decision-analysis-model
#1
REVIEW
Michelle Louie, Jennifer Spencer, Stephanie Wheeler, Victoria Ellis, Tarek Toubia, Lauren D Schiff, Matthew T Siedhoff, Janelle K Moulder
BACKGROUND: A better understanding of the relative risks and benefits of common treatment options for abnormal uterine bleeding (AUB) can help providers and patients to make balanced, evidence-based decisions. OBJECTIVES: To provide comparative estimates of clinical outcomes after placement of levonorgestrel-releasing intrauterine system (LNG-IUS), ablation, or hysterectomy for AUB. SEARCH STRATEGY: A PubMED search was done using combinations of search terms related to abnormal uterine bleeding, LNG-IUS, hysterectomy, endometrial ablation, cost-benefit analysis, cost-effectiveness, and quality-adjusted life years...
August 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28795408/novasure-radiofrequency-endometrial-ablation-for-the-management-of-acute-abnormal-uterine-bleeding
#2
Shamma Al-Inizi
Radiofrequency endometrial ablation resulted in abrupt cessation of acute abnormal uterine bleeding in one case, avoiding emergency hysterectomy. Acute abnormal uterine bleeding (AUB) unrelated to pregnancy is defined as an episode of bleeding that is sufficient in volume in the opinion of the treating clinician to require urgent or emergency intervention.(1) Acute AUB is a distressing condition that poses a challenge for clinicians and consumes healthcare resources. This article is protected by copyright. All rights reserved...
August 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28763739/risk-of-malignancy-on-suspicion-of-polyps-in-menopausal-women
#3
Sandra Bel, Camille Billard, Julien Godet, Victor Viviani, Cherif Akladios, Aline Host, Emilie Faller, Thomas Boisrame, Michel Hummel, Jean-Jacques Baldauf, Lise Lecointre, Olivier Garbin
Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. In order to do so, risk factors for malignancy need to be identified. OBJECTIVE: Estimate the prevalence of lesions in menopausal patients with a pre-operative diagnosis of endometrial polyp...
July 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28748975/correction-ultra-low-fouling-alkylimidazolium-modified-surfaces-for-the-detection-of-her2-in-breast-cancer-cell-lysates
#4
Alexandra Aubé, Shirley Campbell, Andreea R Schmitzer, Audrey Claing, Jean-François Masson
Correction for 'Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates' by Alexandra Aubé et al., Analyst, 2017, 142, 2343-2353.
August 7, 2017: Analyst
https://www.readbyqxmd.com/read/28746365/cbp80-is-needed-for-the-expression-of-pirna-components-and-pirnas
#5
Ravish Rashpa, Paula Vazquez-Pianzola, Martino Colombo, Greco Hernandez, Dirk Beuchle, Fabienne Berger, Stephan Peischl, Rémy Bruggmann, Beat Suter
Cap binding protein 80 (Cbp80) is the larger subunit of the nuclear cap-binding complex (nCBC), which is known to play important roles in nuclear mRNA processing, export, stability and quality control events. Reducing Cbp80 mRNA levels in the female germline revealed that Cbp80 is also involved in defending the germline against transposable elements. Combining such knockdown experiments with large scale sequencing of small RNAs further showed that Cbp80 is involved in the initial biogenesis of piRNAs as well as in the secondary biogenesis pathway, the ping-pong amplification cycle...
2017: PloS One
https://www.readbyqxmd.com/read/28740600/seeking-and-finding-biased-ligands-of-the-kappa-opioid-receptor
#6
Laura M Bohn, Jeffrey Aubé
The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28716637/update-on-the-management-of-abnormal-uterine-bleeding
#7
Y Levy-Zauberman, A-G Pourcelot, P Capmas, H Fernandez
Abnormal uterine bleeding (AUB) is a common complaint that affects large numbers of women from puberty to menopause. It negatively affects health by causing anemia, and impacts the quality of life of women affected. AUB also has an economic impact for both women and society. Therefore, it should not be under- or overestimate and diagnosis, investigations and treatment should be proposed, taking into account the scientific data available in the current state of medical knowledge. Using the new terminology and etiologic classification of AUB is essential to communicate properly around the subject...
July 15, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28710228/longitudinal-qualitative-study-describing-family-physicians-experiences-with-attempting-to-integrate-physical-activity-prescriptions-in-their-practice-it-s-not-easy-to-change-habits
#8
Mathieu Bélanger, Emily Wolfe Phillips, Connor O'Rielly, Bertin Mallet, Shane Aubé, Marylène Doucet, Jonathan Couturier, Maxime Mallet, Jessica Martin, Christine Gaudet, Nathalie Murphy, Jennifer Brunet
OBJECTIVE: Physical activity (PA) prescriptions provided by family physicians can promote PA participation among patients, but few physicians regularly write PA prescriptions. The objective of this study was to describe family physicians' experiences of trying to implement written PA prescriptions into their practice. DESIGN: Longitudinal qualitative study where participants were interviewed four times during a 12-month period. After the first interview, they were provided with PA prescription pads...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28636348/development-of-an-aryloxazole-class-of-hepatitis-c-virus-inhibitors-targeting-the-entry-stage-of-the-viral-replication-cycle
#9
Shanshan He, Kelin Li, Billy Lin, Zongyi Hu, Jingbo Xiao, Xin Hu, Amy Q Wang, Xin Xu, Marc Ferrer, Noel Southall, Wei Zheng, Jeffrey Aubé, Frank J Schoenen, Juan J Marugan, T Jake Liang, Kevin J Frankowski
Reliance on hepatitis C virus (HCV) replicon systems and protein-based screening assays has led to treatments that target HCV viral replication proteins. The model does not encompass other viral replication cycle steps such as entry, processing, assembly and secretion, or viral host factors. We previously applied a phenotypic high-throughput screening platform based on an infectious HCV system and discovered an aryloxazole-based anti-HCV hit. Structure-activity relationship studies revealed several compounds exhibiting EC50 values below 100 nM...
July 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28609937/generic-reclassification-of-species-formerly-included-in-i-rhantus-i-dejean-coleoptera-dytiscidae-colymbetinae
#10
Michael Balke, Jiří Hájek, Lars Hendrich
A reclassification of several species traditionally included in Rhantus Dejean, 1833 is given: Nartus Zaitzev, 1907 is re-instated as genus with one species in the Nearctic and one in the Palaearctic region; two new genera are erected: Meri-diorhantus n. gen., with M. antarcticus (Germain, 1854) n. comb., M. calidus (Fabricius, 1792) n. comb., M. limbatus (Aubé, 1838) n. comb., M. orbignyi (Balke, 1992) n. comb., M. validus (Sharp, 1882) n. comb. in the Neotropical region (M. calidus also in the southern USA and along the eastern coast as far north as New York City), and the monotypic Caperhantus n...
April 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28591707/identification-of-novel-small-molecule-beclin-1-mimetics-activating-autophagy
#11
Jia Yu, Lan Lan, Seth J Lewin, Steven A Rogers, Anuradha Roy, Xiaoqing Wu, Philip Gao, John Karanicolas, Jeffrey Aubé, Baiwang Sun, Liang Xu
Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger autophagy. In order to identify small molecule Beclin 1 mimetics, a fluorescence polarization-based high-throughput screening of 50,316 compounds was carried out with a Z' score of 0.82 ± 0.05, and an outcome of 58 hits. After the structure analysis, three acridine analogues were unveiled and confirmed using the fluorescence polarization assay and the surface plasmon resonance assay...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28586596/histological-pattern-of-endometrial-samples-in-postmenopausal-women-with-abnormal-uterine-bleeding
#12
Farhat Deeba, Shaista, Bushra Khan
BACKGROUND: Abnormal uterine bleeding is one of the most common clinical problems in gynaecological practice and is an indicator of various underlying disorders. An endometrial biopsy should be done in all women over 35 years with AUB to rule out endometrial cancer or pre-malignant lesion and to initiate treatment. However, wide range of histological patterns on endometrial biopsy offer a diagnostic challenge to practicing pathologists. The objective of this study was to determine histological patterns of endometrium in postmenopausal women with abnormal uterine bleeding...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28560368/ultra-low-fouling-methylimidazolium-modified-surfaces-for-the-detection-of-her2-in-breast-cancer-cell-lysates
#13
Alexandra Aubé, Shirley Campbell, Andreea R Schmitzer, Audrey Claing, Jean-François Masson
We synthesized novel ultra-low fouling ionic liquids and demonstrated their use with surface plasmon resonance (SPR) sensing for the analysis of HER2 in breast cancer cell lysates. Whilst biomarkers are commonly detected in serum, this remains challenging for cancer diagnosis due to their low concentrations in circulation and in some cases, there is a poor correlation between serum and tissue concentrations. Therefore, a cell lysate constitutes an interesting biosample for cancer diagnosis and typing, which has been largely unexploited for chemical biosensing of cancer biomarkers...
May 31, 2017: Analyst
https://www.readbyqxmd.com/read/28541028/correction-to-structure-activity-relationship-studies-of-functionally-selective-kappa-opioid-receptor-agonists-that-modulate-erk-1-2-phosphorylation-while-preserving-g-protein-over-%C3%AE-arrestin2-signaling-bias
#14
Kimberly M Lovell, Kevin J Frankowski, Edward L Stahl, Stephen R Slauson, Euna Yoo, Thomas E Prisinzano, Jeffrey Aubé, Laura M Bohn
No abstract text is available yet for this article.
May 25, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28537655/comparative-effectiveness-and-impact-on-health-related-quality-of-life-of-hysterectomy-vs-levonorgestrel-intra-uterine-system-for-abnormal-uterine-bleeding
#15
G Cozza, A Pinto, V Giovanale, P Bianchi, A Guarino, R Marziani, A Frega, D Caserta
OBJECTIVE: To compare hysterectomy and levonorgestrel intra-uterine system (LNG-IUS) for the treatment of abnormal uterine bleeding (AUB) and iron deficiency anemia. PATIENTS AND METHODS: Retrospective study evaluating quality of life, sexual function, satisfaction and blood hemoglobin concentration improvement in 60 pre-menopausal women treated with hysterectomy or LNG-IUS. All analysis was performed with statistical software SPSS 21.0 (SPSS Inc., Chicago, IL, USA)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28500899/hysteroscopy-in-the-treatment-of-uterine-cesarean-section-scar-diverticulum-a-systematic-review
#16
REVIEW
Anna Abacjew-Chmylko, Dariusz G Wydra, Hanna Olszewska
The aim of this paper is to review and to analyze the results of previous studies dealing with hysteroscopic treatment of postcesarean scar defects. A systematic review of publications indexed in MEDLINE/PubMed database identified a total of 11 studies dealing with resectoscopic treatment of postcesarean scar defect. The review was conducted in line with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the PRISMA statement. In only few studies, patients were qualified for hysteroscopic surgery based on the measurement of the defect depth and thickness of residual myometrium above the pouch...
May 10, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28490881/risk-of-obstructive-sleep-apnea-and-excessive-daytime-sleepiness-in-hospitalized-psychiatric-patients
#17
Farid R Talih, Jean J Ajaltouni, Hani M Tamim, Firas H Kobeissy
OBJECTIVES: This study evaluated the risk of developing obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) in hospitalized psychiatric patients at the American University of Beirut Medical Center (AUB-MC). Factors associated with OSA and EDS occurrence in this sample were also examined. METHODS: The Berlin questionnaire and the Epworth sleepiness scale; which respectively evaluate OSA and EDS symptoms, were administered to individuals hospitalized at an acute psychiatric treatment unit at the AUB-MC between the dates of January 2014 and October 2016...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28479313/abnormal-uterine-bleeding-in-women-receiving-direct-oral-anticoagulants-for-the-treatment-of-venous-thromboembolism
#18
REVIEW
Richard Godin, Violaine Marcoux, Vicky Tagalakis
Abnormal uterine bleeding (AUB) is a common complication of anticoagulant therapy in premenopausal women affected with acute venous thromboembolism. AUB impacts quality of life, and can lead to premature cessation of anticoagulation. There is increasing data to suggest that the direct oral anticoagulants when used for the treatment of venous thromboembolism differ in their menstrual bleeding profile. This article aims to review the existing literature regarding the association between AUB and the direct oral anticoagulants and make practical recommendations...
May 4, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28472862/three-dimensional-saline-infusion-sonography-compared-to-two-dimensional-saline-infusion-sonography-for-the-diagnosis-of-focal-intracavitary-lesions
#19
REVIEW
Lotte L Nieuwenhuis, Frederik Jr Hermans, A J Marjolein Bij de Vaate, Mariska Mg Leeflang, Hans Am Brölmann, Wouter Jk Hehenkamp, Ben Willem J Mol, T Justin Clark, Judith Af Huirne
BACKGROUND: Focal abnormalities most commonly acquired within the uterine cavity include endometrial polyps (arising from the endometrium) and submucous fibroids (arising from the myometrium). These benign abnormalities can cause several problems, including abnormal uterine bleeding (AUB) and subfertility. Two-dimensional saline infusion sonography (2D SIS) is a minimally invasive test that can be used to diagnose these pathologies, but it is less accurate than hysteroscopy, which is a more invasive procedure by which an endoscope allows direct visualisation of the uterine cavity...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28462159/lumbar-artery-pseudoaneurysm-a-complication-of-percutaneous-nephrostomy
#20
Melody Djuimo, Melanie Aubé, Mathieu Beland, Claudio Jeldres, Michel Carmel, Andrew Benko
A 21 year-old male underwent nephrostomy tube insertion for hydronephrosis due to a large para-aortic adenopathy of a testicular tumor. In order to reduce infections during chemotherapy, a ureteral stent was placed. While removing the nephrostomy tube, a pulsatile bleeding was found and a renal angiography was done. A pseudoaneurysm of his first left lumbar (L1) artery communicating with the nephrostomy's access site was found. An embolization was performed with coils in the left L1 artery and one of its subdivisions...
July 2017: Urology Case Reports
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