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McCarroll, S A

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https://www.readbyqxmd.com/read/29643358/polygenic-risk-for-schizophrenia-and-measured-domains-of-cognition-in-individuals-with-psychosis-and-controls
#1
Rebecca Shafee, Pranav Nanda, Jaya L Padmanabhan, Neeraj Tandon, Ney Alliey-Rodriguez, Sreeja Kalapurakkel, Daniel J Weiner, Raquel E Gur, Richard S E Keefe, Scot K Hill, Jeffrey R Bishop, Brett A Clementz, Carol A Tamminga, Elliot S Gershon, Godfrey D Pearlson, Matcheri S Keshavan, John A Sweeney, Steven A McCarroll, Elise B Robinson
Psychotic disorders including schizophrenia are commonly accompanied by cognitive deficits. Recent studies have reported negative genetic correlations between schizophrenia and indicators of cognitive ability such as general intelligence and processing speed. Here we compare the effect of polygenetic risk for schizophrenia (PRSSCZ ) on measures that differ in their relationships with psychosis onset: a measure of current cognitive abilities (the Brief Assessment of Cognition in Schizophrenia, BACS) that is greatly reduced in psychotic disorder patients, a measure of premorbid intelligence that is minimally affected by psychosis onset (the Wide-Range Achievement Test, WRAT); and educational attainment (EY), which covaries with both BACS and WRAT...
April 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29643232/increased-neutrophil-extracellular-trap-formation-promotes-thrombosis-in-myeloproliferative-neoplasms
#2
Ofir Wolach, Rob S Sellar, Kimberly Martinod, Deya Cherpokova, Marie McConkey, Ryan J Chappell, Alexander J Silver, Dylan Adams, Cecilia A Castellano, Rebekka K Schneider, Robert F Padera, Daniel J DeAngelo, Martha Wadleigh, David P Steensma, Ilene Galinsky, Richard M Stone, Giulio Genovese, Steven A McCarroll, Bozenna Iliadou, Christina Hultman, Donna Neuberg, Ann Mullally, Denisa D Wagner, Benjamin L Ebert
Thrombosis is a major cause of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), clonal disorders of hematopoiesis characterized by activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. Neutrophil extracellular trap (NET) formation, a component of innate immunity, has been linked to thrombosis. We demonstrate that neutrophils from patients with MPNs are primed for NET formation, an effect blunted by pharmacological inhibition of JAK signaling...
April 11, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29559291/deep-learning-algorithm-for-auto-delineation-of-high-risk-oropharyngeal-clinical-target-volumes-with-built-in-dice-similarity-coefficient-parameter-optimization-function
#3
Carlos E Cardenas, Rachel E McCarroll, Laurence E Court, Baher A Elgohari, Hesham Elhalawani, Clifton D Fuller, Mona J Kamal, Mohamed A M Meheissen, Abdallah S R Mohamed, Arvind Rao, Bowman Williams, Andrew Wong, Jinzhong Yang, Michalis Aristophanous
PURPOSE: Automating and standardizing the contouring of clinical target volumes (CTVs) can reduce interphysician variability, which is one of the largest sources of uncertainty in head and neck radiation therapy. In addition to using uniform margin expansions to auto-delineate high-risk CTVs, very little work has been performed to provide patient- and disease-specific high-risk CTVs. The aim of the present study was to develop a deep neural network for the auto-delineation of high-risk CTVs...
February 7, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29491149/targeted-doxorubicin-loaded-bacterially-derived-nano-cells-for-the-treatment-of-neuroblastoma
#4
Sharon M Sagnella, Jennifer Trieu, Himanshu Brahmbhatt, Jennifer A MacDiarmid, Alex MacMillan, Renee M Whan, Christopher M Fife, Joshua A McCarroll, Andrew J Gifford, David S Ziegler, Maria Kavallaris
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to improve treatment efficacy and reduce toxicity associated with systemic chemotherapy. The EnGeneIC Dream Vector (EDVTM ) is a nanocell, which can package chemotherapeutic drugs and target tumors via attachment of bispecific proteins to the surface of the nanocell. Phase I trials in adults with refractory tumors have shown an acceptable safety profile...
May 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29296025/genome-wide-common-and-rare-variant-analysis-provides-novel-insights-into-clozapine-associated-neutropenia
#5
S E Legge, M L Hamshere, S Ripke, A F Pardinas, J I Goldstein, E Rees, A L Richards, G Leonenko, L F Jorskog, K D Chambert, D A Collier, G Genovese, I Giegling, P Holmans, A Jonasdottir, G Kirov, S A McCarroll, J H MacCabe, K Mantripragada, J L Moran, B M Neale, H Stefansson, D Rujescu, M J Daly, P F Sullivan, M J Owen, M C O'Donovan, J T R Walters
This corrects the article DOI: 10.1038/mp.2016.97.
January 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29064472/genome-wide-association-studies-of-smooth-pursuit-and-antisaccade-eye-movements-in-psychotic-disorders-findings-from-the-b-snip-study
#6
R Lencer, L J Mills, N Alliey-Rodriguez, R Shafee, A M Lee, J L Reilly, A Sprenger, J E McDowell, S A McCarroll, M S Keshavan, G D Pearlson, C A Tamminga, B A Clementz, E S Gershon, J A Sweeney, J R Bishop
Eye movement deviations, particularly deficits of initial sensorimotor processing and sustained pursuit maintenance, and antisaccade inhibition errors, are established intermediate phenotypes for psychotic disorders. We here studied eye movement measures of 849 participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study (schizophrenia N=230, schizoaffective disorder N=155, psychotic bipolar disorder N=206 and healthy controls N=258) as quantitative phenotypes in relation to genetic data, while controlling for genetically derived ancestry measures, age and sex...
October 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29030345/runx1-deficiency-protects-against-adverse-cardiac-remodeling-after-myocardial-infarction
#7
Charlotte S McCarroll, Weihong He, Kirsty Foote, Ashley Bradley, Karen Mcglynn, Francesca Vidler, Colin Nixon, Katrin Nather, Caroline Fattah, Alexandra Riddell, Peter Bowman, Elspeth B Elliott, Margaret Bell, Catherine Hawksby, Scott M MacKenzie, Liam J Morrison, Anne Terry, Karen Blyth, Godfrey L Smith, Martin W McBride, Thomas Kubin, Thomas Braun, Stuart A Nicklin, Ewan R Cameron, Christopher M Loughrey
BACKGROUND: Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Runx1 transcription factor is increased in adult cardiomyocytes after MI; however, the functional role of Runx1 in the heart is unknown...
January 2, 2018: Circulation
https://www.readbyqxmd.com/read/28965813/documented-family-violence-and-risk-of-suicide-attempt-among-u-s-army-soldiers
#8
Robert J Ursano, Murray B Stein, Holly B Herberman Mash, James A Naifeh, Carol S Fullerton, Alan M Zaslavsky, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Ronald C Kessler
Suicide attempt (SA) rates in the U.S. Army increased substantially during the wars in Afghanistan and Iraq. This study examined associations of family violence (FV) history with SA risk among soldiers. Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS), we identified person-month records of active duty, Regular Army, enlisted soldiers with medically documented SAs from 2004 to 2009 (n = 9650) and a sample of control person-months (n = 153,528). Logistic regression analyses examined associations of FV with SA, adjusting for socio-demographics, service-related characteristics, and prior mental health diagnosis...
September 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28746705/risk-of-suicide-attempt-among-soldiers-in-army-units-with-a-history-of-suicide-attempts
#9
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Paul D Bliese, Alan M Zaslavsky, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Murray B Stein
Importance: Mental health of soldiers is adversely affected by the death and injury of other unit members, but whether risk of suicide attempt is influenced by previous suicide attempts in a soldier's unit is unknown. Objective: To examine whether a soldier's risk of suicide attempt is influenced by previous suicide attempts in that soldier's unit. Design, Setting, and Participants: Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS), this study identified person-month records for all active-duty, regular US Army, enlisted soldiers who attempted suicide from January 1, 2004, through December 31, 2009 (n = 9650), and an equal-probability sample of control person-months (n = 153 528)...
September 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28697632/deployment-status-and-child-neglect-types-in-the-u-s-army
#10
Stephen J Cozza, Gloria L Whaley, Joscelyn E Fisher, Jing Zhou, Claudio D Ortiz, James E McCarroll, Carol S Fullerton, Robert J Ursano
Increases in combat deployments have been associated with rises in rates of child neglect in U.S. military families. Although various types of child neglect have been described in military families, it is unknown whether deployment status is associated with specific types of child neglect and whether other factors, such as substance misuse, play a role. To determine the contribution of service member deployment status to the risk of specific child neglect types, data were collected from 390 substantiated U...
February 2018: Child Maltreatment
https://www.readbyqxmd.com/read/28585732/cost-effective-immobilization-for-whole-brain-radiation-therapy
#11
Ashley E Rubinstein, W Scott Ingram, Brian M Anderson, Skylar S Gay, Xenia J Fave, Rachel B Ger, Rachel E McCarroll, Constance A Owens, Tucker J Netherton, Kelly D Kisling, Laurence E Court, Jinzhong Yang, Yuting Li, Joonsang Lee, Dennis S Mackin, Carlos E Cardenas
To investigate the inter- and intra-fraction motion associated with the use of a low-cost tape immobilization technique as an alternative to thermoplastic immobilization masks for whole-brain treatments. The results of this study may be of interest to clinical staff with severely limited resources (e.g., in low-income countries) and also when treating patients who cannot tolerate standard immobilization masks. Setup reproducibility of eight healthy volunteers was assessed for two different immobilization techniques...
June 6, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28545424/suicide-attempts-in-u-s-army-combat-arms-special-forces-and-combat-medics
#12
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Murray B Stein
BACKGROUND: The U.S. Army suicide attempt rate increased sharply during the wars in Iraq and Afghanistan. Risk may vary according to occupation, which significantly influences the stressors that soldiers experience. METHODS: Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS), we identified person-month records for all active duty Regular Army enlisted soldiers who had a medically documented suicide attempt from 2004 through 2009 (n = 9650) and an equal-probability sample of control person-months (n = 153,528)...
May 25, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28445462/cell-diversity-and-network-dynamics-in-photosensitive-human-brain-organoids
#13
Giorgia Quadrato, Tuan Nguyen, Evan Z Macosko, John L Sherwood, Sung Min Yang, Daniel R Berger, Natalie Maria, Jorg Scholvin, Melissa Goldman, Justin P Kinney, Edward S Boyden, Jeff W Lichtman, Ziv M Williams, Steven A McCarroll, Paola Arlotta
In vitro models of the developing brain such as three-dimensional brain organoids offer an unprecedented opportunity to study aspects of human brain development and disease. However, the cells generated within organoids and the extent to which they recapitulate the regional complexity, cellular diversity and circuit functionality of the brain remain undefined. Here we analyse gene expression in over 80,000 individual cells isolated from 31 human brain organoids. We find that organoids can generate a broad diversity of cells, which are related to endogenous classes, including cells from the cerebral cortex and the retina...
May 4, 2017: Nature
https://www.readbyqxmd.com/read/28291911/reproducibility-of-patient-setup-in-the-seated-treatment-position-a-novel-treatment-chair-design
#14
Rachel E McCarroll, Beth M Beadle, Danna Fullen, Peter A Balter, David S Followill, Francesco C Stingo, Jinzhong Yang, Laurence E Court
Radiotherapy in a seated position may be indicated for patients who are unable to lie on the treatment couch for the duration of treatment, in scenarios where a seated treatment position provides superior anatomical positioning and dose distributions, or for a low-cost system designed using a fixed treatment beam and rotating seated patient. In this study, we report a novel treatment chair that was constructed to allow for three-dimensional imaging and treatment delivery while ensuring robust immobilization, providing reproducibility equivalent to that in the traditional supine position...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28173151/exclusive-expression-of-mecp2-in-the-nervous-system-distinguishes-between-brain-and-peripheral-rett-syndrome-like-phenotypes
#15
Paul D Ross, Jacky Guy, Jim Selfridge, Bushra Kamal, Noha Bahey, K Elizabeth Tanner, Thomas H Gillingwater, Ross A Jones, Christopher M Loughrey, Charlotte S McCarroll, Mark E S Bailey, Adrian Bird, Stuart Cobb
Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in the mouse central nervous system alone recapitulates many features of the disorder. This suggests that RTT is primarily a neurological disorder, although the protein is reportedly widely expressed throughout the body. To determine whether aspects of the RTT phenotype that originate in non-neuronal tissues might have been overlooked, we generated mice in which Mecp2 remains at near normal levels in the nervous system, but is severely depleted elsewhere...
October 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28072414/evidence-for-genetic-heterogeneity-between-clinical-subtypes-of-bipolar-disorder
#16
A W Charney, D M Ruderfer, E A Stahl, J L Moran, K Chambert, R A Belliveau, L Forty, K Gordon-Smith, A Di Florio, P H Lee, E J Bromet, P F Buckley, M A Escamilla, A H Fanous, L J Fochtmann, D S Lehrer, D Malaspina, S R Marder, C P Morley, H Nicolini, D O Perkins, J J Rakofsky, M H Rapaport, H Medeiros, J L Sobell, E K Green, L Backlund, S E Bergen, A Juréus, M Schalling, P Lichtenstein, P Roussos, J A Knowles, I Jones, L A Jones, C M Hultman, R H Perlis, S M Purcell, S A McCarroll, C N Pato, M T Pato, N Craddock, M Landén, J W Smoller, P Sklar
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P=3.28 × 10-8 ) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28051972/characteristics-classification-and-prevention-of-child-maltreatment-fatalities
#17
REVIEW
James E McCarroll, Joscelyn E Fisher, Stephen J Cozza, Renè J Robichaux, Carol S Fullerton
BACKGROUND: Preventing child maltreatment fatalities is a critical goal of the U.S. society and the military services. Fatality review boards further this goal through the analysis of circumstances of child deaths, making recommendations for improvements in practices and policies, and promoting increased cooperation among the many systems that serve families. The purpose of this article is to review types of child maltreatment death, proposed classification models, risk and protective factors, and prevention strategies...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/27978950/gene-therapy-with-angiotensin-1-9-preserves-left-ventricular-systolic-function-after-myocardial-infarction
#18
Caroline Fattah, Katrin Nather, Charlotte S McCarroll, Maria P Hortigon-Vinagre, Victor Zamora, Monica Flores-Munoz, Lisa McArthur, Lorena Zentilin, Mauro Giacca, Rhian M Touyz, Godfrey L Smith, Christopher M Loughrey, Stuart A Nicklin
BACKGROUND: Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic mini-pump. Here, we investigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarction (MI). OBJECTIVES: The authors evaluated effects of Ang-(1-9) gene therapy on myocardial structural and functional remodeling post-infarction...
December 20, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958745/an-empirical-dynamical-barrier-for-statistical-theory-of-low-energy-reactive-s-1-d-hd-j-0-h-2-j-0-collisions
#19
Tasko P Grozdanov, Ronald McCarroll
A simple model potential is proposed to describe the dynamical barrier in the mean interaction potential at small distances between the reactants in S(1 D) + HD(1 Σ, v = 0, j = 0) reaction. The statistical theory of collision complex formation and complex decay is applied to calculate the total reaction cross sections and the cross sections for SH and SD productions in the range of low collision energies Ec = (0.4-60) meV. The results are compared with measured cross sections and results of hyperspherical close coupling calculations...
January 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27897318/medically-documented-suicide-ideation-among-u-s-army-soldiers
#20
Robert J Ursano, Ronald C Kessler, Murray B Stein, James A Naifeh, Matthew K Nock, Pablo A Aliaga, Carol S Fullerton, Gary H Wynn, Tsz Hin Hinz Ng, Hieu M Dinh, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, James E McCarroll, Kenneth L Cox, Steven G Heeringa
We used administrative data to examine predictors of medically documented suicide ideation (SI) among Regular Army soldiers from 2006 through 2009 (N = 10,466 ideators, 124,959 control person-months). Enlisted ideators (97.8% of all cases) were more likely than controls to be female, younger, older when entering service, less educated, never or previously deployed, and have a recent mental health diagnosis. Officer ideators were more likely than controls to be female, younger, younger when entering service, never married, and have a recent mental health diagnosis...
October 2017: Suicide & Life-threatening Behavior
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