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task force brain trauma

T Lin, A Simchovitz, S Shenhar-Tsarfaty, S Vaisvaser, R Admon, G Hanin, M Hanan, E Kliper, Y Bar-Haim, N Shomron, G Fernandez, G Lubin, E Fruchter, T Hendler, H Soreq
Trauma causes variable risk of posttraumatic stress symptoms (PTSS) owing to yet-unknown genome-neuronal interactions. Here, we report co-intensified amygdala and ventromedial prefrontal cortex (vmPFC) emotional responses that may overcome PTSS in individuals with the single-nucleotide polymorphism (SNP) rs17228616 in the acetylcholinesterase (AChE) gene. We have recently shown that in individuals with the minor rs17228616 allele, this SNP interrupts AChE suppression by microRNA (miRNA)-608, leading to cortical elevation of brain AChE and reduced cortisol and the miRNA-608 target GABAergic modulator CDC42, all stress-associated...
2016: Translational Psychiatry
Gerald Pichler, Franz Fazekas
BACKGROUND: The "Unresponsive wakefulness syndrome" (UWS) or previously termed vegetative state is a possible consequence of severe brain damage where individuals just open their eyes but show no conscious behavioural reaction. While head trauma has previously been considered the prevailing cause, clinical experience suggests shows that cardiopulmonary arrest plays an increasingly important role. We therefore attempted to study this hypothesis in a well-defined region of Austria. METHODS: Prospective population-based cohort study to calculate the incidence and aetiologies of the UWS...
June 2016: Resuscitation
Mary R Newsome, Sally Durgerian, Lyla Mourany, Randall S Scheibel, Mark J Lowe, Erik B Beall, Katherine A Koenig, Michael Parsons, Maya Troyanskaya, Christine Reece, Elisabeth Wilde, Barbara L Fischer, Stephen E Jones, Rajan Agarwal, Harvey S Levin, Stephen M Rao
Mild to moderate traumatic brain injury (TBI) due to blast exposure is frequently diagnosed in veterans returning from the wars in Iraq and Afghanistan. However, it is unclear whether neural damage resulting from blast TBI differs from that found in TBI due to blunt-force trauma (e.g., falls and motor vehicle crashes). Little is also known about the effects of blast TBI on neural networks, particularly over the long term. Because impairment in working memory has been linked to blunt-force TBI, the present functional magnetic resonance imaging (fMRI) study sought to investigate whether brain activation in response to a working memory task would discriminate blunt-force from blast TBI...
2015: NeuroImage: Clinical
Zachary M Weil, Kristopher R Gaier, Kate Karelina
Repeated head injuries are a major public health concern both for athletes, and members of the police and armed forces. There is ample experimental and clinical evidence that there is a period of enhanced vulnerability to subsequent injury following head trauma. Injuries that occur close together in time produce greater cognitive, histological, and behavioral impairments than do injuries separated by a longer period. Traumatic brain injuries alter cerebral glucose metabolism and the resolution of altered glucose metabolism may signal the end of the period of greater vulnerability...
October 2014: Neurobiology of Disease
Vicki L Kristman, Jörgen Borg, Alison K Godbolt, L Rachid Salmi, Carol Cancelliere, Linda J Carroll, Lena W Holm, Catharina Nygren-de Boussard, Jan Hartvigsen, Uko Abara, James Donovan, J David Cassidy
The International Collaboration on Mild Traumatic Brain Injury (MTBI) Prognosis performed a comprehensive search and critical review of the literature from 2001 to 2012 to update the 2002 best-evidence synthesis conducted by the World Health Organization Collaborating Centre for Neurotrauma, Prevention, Management and Rehabilitation Task Force on the prognosis of MTBI. Of 299 relevant studies, 101 were accepted as scientifically admissible. The methodological quality of the research literature on MTBI prognosis has not improved since the 2002 Task Force report...
March 2014: Archives of Physical Medicine and Rehabilitation
Eleanor Boyle, Carol Cancelliere, Jan Hartvigsen, Linda J Carroll, Lena W Holm, J David Cassidy
OBJECTIVE: The World Health Organization Collaborating Centre Task Force on Mild Traumatic Brain Injury (MTBI) published its findings on the prognosis of MTBI in 2004. This is an update of that review with a focus on deployed military personnel. DATA SOURCES: Relevant literature published between January 2001 and February 2012 listed in MEDLINE and 4 other databases. STUDY SELECTION: Controlled trials and cohort and case-control studies were selected according to predefined criteria...
March 2014: Archives of Physical Medicine and Rehabilitation
J David Cassidy, Carol Cancelliere, Linda J Carroll, Pierre Côté, Cesar A Hincapié, Lena W Holm, Jan Hartvigsen, James Donovan, Catharina Nygren-de Boussard, Vicki L Kristman, Jörgen Borg
OBJECTIVE: To update the mild traumatic brain injury (MTBI) prognosis review published by the World Health Organization Task Force in 2004. DATA SOURCES: MEDLINE, PsycINFO, Embase, CINAHL, and SPORTDiscus were searched from 2001 to 2012. We included published, peer-reviewed studies with more than 30 adult cases. STUDY SELECTION: Controlled trials and cohort and case-control studies were selected according to predefined criteria. Studies had to assess subjective, self-reported outcomes...
March 2014: Archives of Physical Medicine and Rehabilitation
Barbara L Fischer, Michael Parsons, Sally Durgerian, Christine Reece, Lyla Mourany, Mark J Lowe, Erik B Beall, Katherine A Koenig, Stephen E Jones, Mary R Newsome, Randall S Scheibel, Elisabeth A Wilde, Maya Troyanskaya, Tricia L Merkley, Mark Walker, Harvey S Levin, Stephen M Rao
Military personnel involved in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) commonly experience blast-induced mild to moderate traumatic brain injury (TBI). In this study, we used task-activated functional MRI (fMRI) to determine if blast-related TBI has a differential impact on brain activation in comparison with TBI caused primarily by mechanical forces in civilian settings. Four groups participated: (1) blast-related military TBI (milTBI; n=21); (2) military controls (milCON; n=22); (3) non-blast civilian TBI (civTBI; n=21); and (4) civilian controls (civCON; n=23) with orthopedic injuries...
January 15, 2014: Journal of Neurotrauma
Stefanie Pilge, Gerhard Schneider
Awareness is a rare but typical complication during general anesthesia, with a reported incidence of 0.1- 0.2% to 1% (high risk patients) in adults and probably much higher in children with 0.2 -1.2%. Awareness is defined as consciousness during general anesthesia with explicit (conscious) recall of memories.Wakefulness during anesthesia can meet DSM-IV criteria of trauma. Significant long-term psychological sequelae (e.g. post-traumatic stress disorder) may occur.Recommendations of the German Society of Anesthesiologists have been developed according to the ASA Task Force for intraoperative awareness and brain function monitoring...
January 2013: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Teemu M Luoto, Olli Tenovuo, Anneli Kataja, Antti Brander, Juha Öhman, Grant L Iverson
Selection bias, common in traumatic brain injury research, limits the clinical usefulness and generalizability of study findings. The purpose of this study was to examine the effect of different inclusion and exclusion criteria on patient enrollment, and the implications for generalizability, in a mild traumatic brain injury (MTBI) study. The study was conducted at the emergency department (ED) of Tampere University Hospital. Our aim was to study outcome from MTBI in patients who do not have pre-existing conditions or other confounding factors...
January 1, 2013: Journal of Neurotrauma
Carol Cancelliere, J David Cassidy, Pierre Côté, Cesar A Hincapié, Jan Hartvigsen, Linda J Carroll, Connie Marras, Eleanor Boyle, Vicki Kristman, Ryan Hung, Britt-Marie Stålnacke, Peter Rumney, Victor Coronado, Lena W Holm, Jörgen Borg, Catharina Nygren-de Boussard, Jean-Luc Af Geijerstam, Michelle Keightley
BACKGROUND: Mild traumatic brain injury (MTBI) is a major public-health concern and represents 70-90% of all treated traumatic brain injuries. The last best-evidence synthesis, conducted by the WHO Collaborating Centre for Neurotrauma, Prevention, Management and Rehabilitation in 2002, found few quality studies on prognosis. The objective of this review is to update these findings. Specifically, we aim to describe the course, identify modifiable prognostic factors, determine long-term sequelae, and identify effects of interventions for MTBI...
2012: Systematic Reviews
Deepak Sharma, Michael J Souter, Anne E Moore, Arthur M Lam
BACKGROUND: Transcranial Doppler (TCD) ultrasonography to demonstrate cerebral circulatory arrest (CCA) is a confirmatory test for brain death (BD). The primary aim of this retrospective study was to evaluate the practical utility of TCD to confirm BD when clinical diagnosis was not feasible due to confounding factors. Secondary aims were to evaluate the reasons for inability of TCD to confirm BD and to assess the outcome of patients not brain dead according to the TCD criteria. METHODS: TCD waveforms and medical records of all the patients examined to confirm suspected BD between 2001 and 2007, where clinical diagnosis was not possible, were analyzed...
June 2011: Neurocritical Care
M Longo, G D V Hankins
Cerebral palsy (CP) affects 2/1 000 live-born children. There are several antenatal factors, including preterm delivery, low birth weight, infection/inflammation, multiple gestations, and other pregnancy complications, that have been associated with CP in both the preterm and term infant, with birth asphyxia playing a minor role. Due to the increasing survival of the very preterm and very low birth weight infant secondary to improvements in neonatal and obstetric care, the incidence of CP may be increasing...
October 2009: Minerva Ginecologica
Shin-Ying Chu, Steven M Barlow, Jaehoon Lee
PURPOSE: The objective of this study was to extend previous published findings in the authors' laboratory using a new automated technology to quantitatively characterize nonparticipatory perioral stiffness in healthy male adults. METHOD: Quantitative measures of perioral stiffness were sampled during a nonparticipatory task using a computer-controlled linear servo motor to impose a series of tensile displacements over a span of approximately 24 mm at the oral angle in 20 healthy young male adults...
October 2009: Journal of Speech, Language, and Hearing Research: JSLHR
Jacques-Olivier Coq, Ann E Barr, Fabrizio Strata, Michael Russier, David M Kietrys, Michael M Merzenich, Nancy N Byl, Mary F Barbe
Repetitive motion disorders, such as carpal tunnel syndrome and focal hand dystonia, can be associated with tasks that require prolonged, repetitive behaviors. Previous studies using animal models of repetitive motion have correlated cortical neuroplastic changes or peripheral tissue inflammation with fine motor performance. However, the possibility that both peripheral and central mechanisms coexist with altered motor performance has not been studied. In this study, we investigated the relationship between motor behavior changes associated with repetitive behaviors and both peripheral tissue inflammation and cortical neuroplasticity...
December 2009: Experimental Neurology
Ronald M Ruff, Grant L Iverson, Jeffrey T Barth, Shane S Bush, Donna K Broshek
A special interest group of the American Congress of Rehabilitation Medicine [ACRM; Mild Traumatic Brain Injury Committee. (1993). Definition of mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 8 (3), 86-87.] was the first organized interdisciplinary group to advocate four specific criteria for the diagnosis of a mild traumatic brain injury (TBI). More recently, the World Health Organization (WHO) Collaborative Center Task Force on Mild Traumatic Brain Injury [Carroll, L. J., Cassidy, J. D...
February 2009: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Meena Vythilingam, Eric E Nelson, Matthew Scaramozza, Tracy Waldeck, Gary Hazlett, Steven M Southwick, Daniel S Pine, Wayne Drevets, Dennis S Charney, Monique Ernst
Enhanced brain reward function could contribute to resilience to trauma. Reward circuitry in active duty, resilient special forces (SF) soldiers was evaluated using functional magnetic resonance imaging during a monetary incentive delay task. Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes.
April 30, 2009: Psychiatry Research
J Briegel, M Vogeser, D Keh, P Marik
Critically ill patients with severe systemic inflammation can develop critical illness-related corticosteroid insufficiency (CIRCI), which is associated with a poor outcome. A task force of the American College of Critical Care Medicine compiled recommendations for diagnosis and treatment of this clinical entity thereby focusing on patients with septic shock and acute respiratory distress syndrome (ARDS). The results of large scale multi-centre trials gave partially conflicting results arguing against the broad use of corticosteroids in stress doses...
February 2009: Der Anaesthesist
Kim Peterson, Susan Carson, Nancy Carney
In this study, we conducted an updated meta-analysis of the effects of hypothermia therapy on mortality, favorable neurologic outcome, and associated adverse effects in adults with traumatic brain injury (TBI) for use by Brain Trauma Foundation (BTF)/American Association of Neurological Surgeons (AANS) task force to develop evidence-based treatment guidelines. Our data sources relied on handsearches of four previous good-quality systematic reviews, which all conducted electronic searches of primarily MEDLINE (OVID), EMBASE, and Cochrane Library...
January 2008: Journal of Neurotrauma
Jean Schoenen, Franco Gianni, Luc Schretlen, Patrik Sobocki
This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and performed by Stockholm Health Economics. The disorders selected were: addiction, depression, anxiety disorders, brain tumours, dementia, epilepsy, migraine and other headaches, multiple sclerosis, Parkinson's disease, psychotic disorders, stroke and trauma. Figures for prevalence of disorders and direct medical, direct non-medical and indirect costs are based on data coming from available electronic data bases, or when missing for Belgium, best possible estimates or extrapolated data were used...
December 2006: Acta Neurologica Belgica
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