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Patrick luyten

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https://www.readbyqxmd.com/read/27687932/bioluminescent-avian-pathogenic-escherichia-coli-for-monitoring-colibacillosis-in-experimentally-infected-chickens
#1
Leon H Oosterik, Huruma N Tuntufye, Jessica Tsonos, Tom Luyten, Sam Noppen, Sandra Liekens, Rob Lavigne, Patrick Butaye, Bruno M Goddeeris
Avian pathogenic Escherichia coli (APEC) are responsible for significant economic losses in the poultry industry. In this study, a model for investigating the pathogenesis of APEC infections was established. APEC strain CH2 (O78) was marked with the luciferase operon (luxCDABE) using a Tn7 transposon and tissues of experimentally infected chickens were analysed for a correlation between the bioluminescent signal and the number of bacteria. Transposition of the lux operon into the chromosome of the APEC isolate did not affect sensitivity to lytic bacteriophages and there was no effect on virulence in an intratracheal infection model in 1-day-old chicks, although results with a subcutaneous infection model were inconclusive...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27597820/attachment-neurobiology-and-mentalizing-along-the-psychosis-continuum
#2
REVIEW
Martin Debbané, George Salaminios, Patrick Luyten, Deborah Badoud, Marco Armando, Alessandra Solida Tozzi, Peter Fonagy, Benjamin K Brent
In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27392018/development-and-validation-of-a-self-report-measure-of-mentalizing-the-reflective-functioning-questionnaire
#3
Peter Fonagy, Patrick Luyten, Alesia Moulton-Perkins, Ya-Wen Lee, Fiona Warren, Susan Howard, Rosanna Ghinai, Pasco Fearon, Benedicte Lowyck
Reflective functioning or mentalizing is the capacity to interpret both the self and others in terms of internal mental states such as feelings, wishes, goals, desires, and attitudes. This paper is part of a series of papers outlining the development and psychometric features of a new self-report measure, the Reflective Functioning Questionnaire (RFQ), designed to provide an easy to administer self-report measure of mentalizing. We describe the development and initial validation of the RFQ in three studies...
2016: PloS One
https://www.readbyqxmd.com/read/27244268/self-critical-perfectionism-dependency-and-symptomatic-distress-in-patients-with-personality-disorder-during-hospitalization-based-psychodynamic-treatment-a-parallel-process-growth-modeling-approach
#4
Benedicte Lowyck, Patrick Luyten, Rudi Vermote, Yannic Verhaest, Kristof Vansteelandt
There is growing evidence for the efficacy and effectiveness of psychotherapy in patients with personality disorder (PD), but very little is known about the factors underlying these effects. Two-polarities models of personality development provide an empirically supported approach to studying therapeutic change. Briefly, these models argue that personality pathology is characterized by an imbalance between development of the capacity for self-definition and for relatedness, with an exaggerated emphasis on issues regarding self-definition and relatedness being expressed in high levels of self-critical perfectionism (SCP) and dependency, respectively...
May 30, 2016: Personality Disorders
https://www.readbyqxmd.com/read/27050327/serum-of-patients-with-active-rheumatoid-arthritis-inhibits-differentiation-of-osteochondrogenic-precursor-cells
#5
Janak L Pathak, Patrick Verschueren, Willem F Lems, Nathalie Bravenboer, Jenneke Klein-Nulend, Astrid D Bakker, Frank P Luyten
Delayed fracture healing is frequently experienced in patients with systemic inflammation such as during rheumatoid arthritis (RA). The reasons for this are diverse, but could also be caused by inflammatory cytokines and/or growth factors in serum from patients with active disease. We hypothesized that serum from patients with active RA contains circulating inflammatory factors that inhibit differentiation of osteochondrogenic precursors. Serum was obtained from 15 patients with active RA (active RA-sera) and from the same patients in clinical remission 1 year later (remission RA-sera; controls)...
May 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27018923/the-effect-of-childhood-emotional-maltreatment-on-romantic-relationships-in-young-adulthood-a-double-mediation-model-involving-self-criticism-and-attachment
#6
Dana Lassri, Patrick Luyten, Guina Cohen, Golan Shahar
OBJECTIVE: Despite growing recognition of the importance of childhood emotional maltreatment (CEM) on the development of psychopathology, very few studies have addressed its impact on adult romantic relationship functioning, particularly among otherwise relatively well-functioning individuals. In an attempt to further elucidate the mechanism underlying the negative impact of CEM on romantic relationships, we tested an integrative mediational model linking CEM to romantic relationships through the impact of CEM on the development of self-criticism and adult attachment...
July 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27007498/the-role-of-intergenerational-similarity-and-parenting-in-adolescent-self-criticism-an-actor-partner-interdependence-model
#7
Dries Bleys, Bart Soenens, Liesbet Boone, Stephan Claes, Nicole Vliegen, Patrick Luyten
Research investigating the development of adolescent self-criticism has typically focused on the role of either parental self-criticism or parenting. This study used an actor-partner interdependence model to examine an integrated theoretical model in which achievement-oriented psychological control has an intervening role in the relation between parental and adolescent self-criticism. Additionally, the relative contribution of both parents and the moderating role of adolescent gender were examined. Participants were 284 adolescents (M = 14 years, range = 12-16 years) and their parents (M = 46 years, range = 32-63 years)...
June 2016: Journal of Adolescence
https://www.readbyqxmd.com/read/26887974/systemic-inflammation-affects-human-osteocyte-specific-protein-and-cytokine-expression
#8
Janak L Pathak, Astrid D Bakker, Frank P Luyten, Patrick Verschueren, Willem F Lems, Jenneke Klein-Nulend, Nathalie Bravenboer
Bone remodeling can be disturbed in active rheumatoid arthritis (RA), possibly as a result of elevated levels of circulating inflammatory cytokines. Osteocyte-specific proteins and cytokines play a vital role in bone remodeling by orchestrating bone formation and/or bone resorption. Therefore, we aimed to investigate the effect of RA-serum or inflammatory cytokines on expression of human osteocyte-specific proteins and cytokines. Human trabecular bone chips were cultured with RA-serum or inflammatory cytokines for 7-days...
June 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/26863487/hif-1%C3%AE-promotes-glutamine-mediated-redox-homeostasis-and-glycogen-dependent-bioenergetics-to-support-postimplantation-bone-cell-survival
#9
Steve Stegen, Nick van Gastel, Guy Eelen, Bart Ghesquière, Flora D'Anna, Bernard Thienpont, Jermaine Goveia, Sophie Torrekens, Riet Van Looveren, Frank P Luyten, Patrick H Maxwell, Ben Wielockx, Diether Lambrechts, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet
Cell-based therapy is a promising strategy in regenerative medicine, but the poor survival rate of the implanted cells remains a major challenge and limits clinical translation. We preconditioned periosteal cells to the hypoxic and ischemic environment of the bone defect site by deleting prolyl hydroxylase domain-containing protein 2 (PHD2), resulting in hypoxia-inducible factor 1 alpha (HIF-1α) stabilization. This strategy increased postimplantation cell survival and improved bone regeneration. The enhanced cell viability was angiogenesis independent but relied on combined changes in glutamine and glycogen metabolism...
February 9, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/26714319/the-french-version-of-the-reflective-functioning-questionnaire-validity-data-for-adolescents-and-adults-and-its-association-with-non-suicidal-self-injury
#10
Deborah Badoud, Patrick Luyten, Eduardo Fonseca-Pedrero, Stephan Eliez, Peter Fonagy, Martin Debbané
INTRODUCTION: The capacity to understand one's own actions and those of others in terms of cognitive and affective mental states (i.e., reflective functioning or mentalizing) is thought to play a critical role in both typical and atypical development. To date, however, no self-report tool is available for assessing reflective functioning ability in French-speaking samples. The first aim of this study is to investigate the reliability and validity of the reflective functioning questionnaire (RFQ) in French-speaking adolescents and adults...
2015: PloS One
https://www.readbyqxmd.com/read/26690635/self-critical-perfectionism-predicts-lower-cortisol-response-to-experimental-stress-in-patients-with-chronic-fatigue-syndrome
#11
Stefan Kempke, Patrick Luyten, Linda C Mayes, Boudewijn Van Houdenhove, Stephan Claes
OBJECTIVE: Previous studies have suggested that self-critical perfectionism (SCP) may play a role in the development and maintenance of Chronic Fatigue Syndrome (CFS). In this study we investigated whether SCP is related to a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis, which has been shown to be a key factor in the pathophysiology of CFS. METHOD: We conducted a quasi-experimental study to examine the association between SCP (as measured with the Depressive Experiences Questionnaire) and stress reactivity in a sample of 41 female CFS patients...
March 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/26538327/a-hierarchical-multiple-level-approach-to-the-assessment-of-interpersonal-relatedness-and-self-definition-implications-for-research-clinical-practice-and-dsm-planning
#12
Patrick Luyten, Sidney J Blatt
Extant research suggests there is considerable overlap between so-called 2-polarities models of personality development; that is, models that propose that personality development evolves through a dialectic synergistic interaction between 2 key developmental tasks across the life span-the development of self-definition on the one hand and of relatedness on the other. These models have attracted considerable research attention and play a central role in DSM planning. This article provides a researcher- and clinician-friendly guide to the assessment of these personality theories...
2016: Journal of Personality Assessment
https://www.readbyqxmd.com/read/26461044/what-s-in-a-face-mentalizing-in-borderline-personality-disorder-based-on-dynamically-changing-facial-expressions
#13
Benedicte Lowyck, Patrick Luyten, Dominique Vanwalleghem, Rudi Vermote, Linda C Mayes, Michael J Crowley
The mentalization-based approach to borderline personality disorder (BPD) argues that impairments in mentalizing are a key feature of BPD. Most previous research in this area has concentrated on potential impairments in facial emotion recognition in BPD patients. However, these studies have yielded inconsistent results, which may be attributable to methodological differences. This study aimed to address several limitations of previous studies by investigating different parameters involved in emotion recognition in BPD patients using a novel, 2-step dynamically changing facial expression paradigm, taking into account the possible influence of mood, psychotropic medication, and trauma exposure...
January 2016: Personality Disorders
https://www.readbyqxmd.com/read/26436581/translation-mentalizing-as-treatment-target-in-borderline-personality-disorder
#14
REVIEW
Peter Fonagy, Patrick Luyten, Anthony Bateman
The role of mentalizing in relation to borderline personality disorder (BPD) is examined with a view to achieving improved levels of mentalizing in BPD patients as a therapeutic target. The article seeks to explain why mentalizing works as a treatment target for BPD, and suggests that a mentalizing approach to BPD may be at the core of any successful intervention.
October 2015: Personality Disorders
https://www.readbyqxmd.com/read/26436580/the-neurobiology-of-mentalizing
#15
REVIEW
Patrick Luyten, Peter Fonagy
Mentalizing is the capacity to understand ourselves and others in terms of intentional mental states, such as feelings, desires, wishes, attitudes, and goals. It is a fundamental capacity in our complex social environment. This article reviews our current understanding of the neurobiology of mentalizing. We first summarize the key assumptions of the mentalizing approach to normal and disrupted development. This is followed by discussion of the multiple dimensions of mentalizing and our emerging knowledge of the neural circuits that underlie these dimensions...
October 2015: Personality Disorders
https://www.readbyqxmd.com/read/26361007/the-self-beyond-somatic-symptoms-a-narrative-approach-to-self-experience-in-adolescent-chronic-fatigue-syndrome
#16
Stefan M van Geelen, Coralie E Fuchs, Rolf van Geel, Patrick Luyten, Elise M van de Putte
BACKGROUND: The self and self-experience are often assumed to play an important role in adolescent patients presenting with severe somatic symptoms and bodily distress. Nonetheless, most empirical work on this subject is confined to studies of personality and patients' experience of negative emotionality. This study aims to move beyond mere descriptions of symptoms, traits and distress, and consequently adopts a narrative approach to self-experience in adolescent chronic fatigue syndrome (CFS)...
2015: Psychopathology
https://www.readbyqxmd.com/read/26303562/psychodynamic-therapy-meets-evidence-based-medicine-a-systematic-review-using-updated-criteria
#17
REVIEW
Falk Leichsenring, Patrick Luyten, Mark J Hilsenroth, Allan Abbass, Jacques P Barber, John R Keefe, Frank Leweke, Sven Rabung, Christiane Steinert
Psychodynamic therapy (PDT) is an umbrella concept for treatments that operate on an interpretive-supportive continuum and is frequently used in clinical practice. The use of any form of psychotherapy should be supported by sufficient evidence. Efficacy research has been neglected in PDT for a long time. In this review, we describe methodological requirements for proofs of efficacy and summarise the evidence for use of PDT to treat mental health disorders. After specifying the requirements for superiority, non-inferiority, and equivalence trials, we did a systematic search using the following criteria: randomised controlled trial of PDT; use of treatment manuals or manual-like guidelines; use of reliable and valid measures for diagnosis and outcome; adults treated for specific mental problems...
July 2015: Lancet Psychiatry
https://www.readbyqxmd.com/read/26271454/escap-expert-article-borderline-personality-disorder-in-adolescence-an-expert-research-review-with-implications-for-clinical-practice
#18
REVIEW
Peter Fonagy, Mario Speranza, Patrick Luyten, Michael Kaess, Christel Hessels, Martin Bohus
Borderline personality disorder (BPD) has onset in adolescence, but is typically first diagnosed in young adulthood. This paper provides a narrative review of the current evidence on diagnosis, comorbidity, phenomenology and treatment of BPD in adolescence. Instruments available for diagnosis are reviewed and their strengths and limitations discussed. Having confirmed the robustness of the diagnosis and the potential for its reliable clinical assessment, we then explore current understandings of the mechanisms of the disorder and focus on neurobiological underpinnings and research on psychological mechanisms...
November 2015: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/26173889/a-psychoanalytically-informed-hospitalization-based-treatment-of-personality-disorders
#19
Rudi Vermote, Patrick Luyten, Yannic Verhaest, Bart Vandeneede, Hans Vertommen, Benedicte Lowyck
This study presents a model of psychic change in personality disorders focusing on three dimensions: felt safety, mentalization and self-object relations. Based upon this model a hospitalization-based therapy program was created. Four scales to measure these three dimensions on the Object Relation Interview are discussed: the Felt Safety Scale, the Reflective Functioning Scale and the Bion Grid Scale and the Differentiation-Relatedness Scale. A naturalistic symptom outcome study of the program showed a large effect on both symptoms and personality functioning...
June 2015: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/26103626/cxcl8-and-ccl20-enhance-osteoclastogenesis-via-modulation-of-cytokine-production-by-human-primary-osteoblasts
#20
Janak L Pathak, Astrid D Bakker, Patrick Verschueren, Willem F Lems, Frank P Luyten, Jenneke Klein-Nulend, Nathalie Bravenboer
Generalized osteoporosis is common in patients with inflammatory diseases, possibly because of circulating inflammatory factors that affect osteoblast and osteoclast formation and activity. Serum levels of the inflammatory factors CXCL8 and CCL20 are elevated in rheumatoid arthritis, but whether these factors affect bone metabolism is unknown. We hypothesized that CXCL8 and CCL20 decrease osteoblast proliferation and differentiation, and enhance osteoblast-mediated osteoclast formation and activity. Human primary osteoblasts were cultured with or without CXCL8 (2-200 pg/ml) or CCL20 (5-500 pg/ml) for 14 days...
2015: PloS One
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