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Hydroxymethylation

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https://www.readbyqxmd.com/read/28212500/cyto-genotoxic-and-dna-methylation-changes-induced-by-different-crystal-phases-of-tio2-np-in-bronchial-epithelial-16-hbe-cells
#1
Manosij Ghosh, Deniz Öner, Radu-Corneliu Duca, Stevan M Cokic, Sven Seys, Stef Kerkhofs, Kirsten Van Landuyt, Peter Hoet, Lode Godderis
With the increase in use of TiO2-np, a better understanding of their safety is important. In the present study the effect of different crystal phases of TiO2-np (anatase, rutile and anatase: rutile mixture; 20-26nm) were studied for cyto-genotoxicity and global DNA methylation and hydroxymethylation. Cytotoxic response was observed at a concentration of 25μg/ml for the particles tested. Results of comet and micronucleus (with and without CytB) assays revealed significant genotoxic effect of these particles...
February 10, 2017: Mutation Research
https://www.readbyqxmd.com/read/28201966/synthesis-and-biological-evaluation-of-mutual-prodrugs-of-carboxylic-group-containing-some-non-steroidal-anti-inflammatory-drugs-and-propyphenazone
#2
Sucheta Ohlan, Meenu Paliwal, Ruchita Ruchita, Shilpa Jain, Monika Monika, Himanshu Himanshu
Non-steroidal anti-inflammatory drugs (NSAIDs); ketorolac (KA), niflumic acid (NA), tolfenamic acid (TA) were conjugated with propyphenazone derivative 3-Hydroxymethyl propyphenazone (HMP) by direct coupling and by using spacer technique with the objective of obtaining gastro-sparing NSAIDs prodrugs devoid of ulcerogenic side effects. Mutual prodrugs were synthesized and their structures were confirmed and characterized using IR, 1H NMR, 13C NMR, mass spectroscopy and their purity was established by elemental analysis...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28198623/dangling-and-hydrolyzed-ligand-arms-in-mn3-and-mn6-coordination-assemblies-synthesis-characterization-and-functional-activity
#3
Krishna Chattopadhyay, Gavin A Craig, María José Heras Ojea, Moumita Pait, Animesh Kundu, Junseong Lee, Mark Murrie, Antonio Frontera, Debashis Ray
Two flexible, branched, and sterically constrained di- and tripodal side arms around a phenol backbone were utilized in ligands H3L1 and H5L2 to isolate {Mn6} and {Mn3} coordination aggregates. 2,6-Bis{(1-hydroxy-2-methylpropan-2-ylimino)methyl}-4-methylphenol (H3L1) gave trinuclear complex [Mn3(μ-H2L1)2(μ1,3-O2CCH3)4(CH3OH)2](ClO4)2·4CH3OH (1), whereas 2,6-bis[{1-hydroxy-2-(hydroxymethyl)butan-2-ylimino}methyl]-4-methylphenol (H5L2) provided hexanuclear complex [Mn6(μ4-H2L2)2(μ-HL3)2(μ3-OH)2(μ1,3-O2CC2H5)4](ClO4)2·2H2O (2)...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28196653/photosensitizing-anthraquinones-from-heterophyllaea-lycioides-rubiaceae
#4
Jesica A Dimmer, Susana C Núñez Montoya, Caterine S Mendoza, José L Cabrera
Seven anthraquinones were isolated from aerial parts of Heterophyllaea lycioides (Rusby) Sandwith (Rubiaceae), including three derivatives that have not been described before: a hetero-bianthraquinone identified as (R)-2-hydroxymethyl-2'methyl-1,1',6,6'-tetrahydroxy-5,5' bianthraquinone (lycionine), and two mono-chlorinated derivatives related to soranjidiol. One of them is a homo-bianthraquinone: (R)-7-chloro-2,2'-dimethyl-1,1',6,6'-tetrahydroxy-5,5' bianthraquinone (7-chlorobisoranjidiol), whereas the second halogenated derivative corresponds to a monomeric structure: 5-chloro-1,6-dihydroxy-2-methyl anthraquinone (5-chlorosoranjidiol)...
February 10, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28194270/total-synthesis-of-a-key-series-of-vinblastines-modified-at-c4-that-define-the-importance-and-surprising-trends-in-activity
#5
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh, Daniel M Brody, Manuela M Brütsch, Dale L Boger
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which electronically mismatched electron-deficient trisubstituted alkenes and unactivated trisubstituted alkenes were found to productively initiate the cycloaddition cascade with tethered electron-deficient 1,3,4-oxadiazoles...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28193047/accurate-direct-and-high-throughput-analyses-of-a-broad-spectrum-of-endogenously-generated-dna-base-modifications-with-isotope-dilution-two-dimensional-ultraperformance-liquid-chromatography-with-tandem-mass-spectrometry-possible-clinical-implication
#6
Daniel Gackowski, Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Anna Szpila, Zbigniew Banaszkiewicz, Ryszard Olinski
Our hereby presented methodology is suitable for reliable assessment of the most common unavoidable DNA modifications which arise as a product of fundamental metabolic processes. 8-Oxoguanine, one of the oxidatively modified DNA bases, is a typical biomarker of oxidative stress. A noncanonical base, uracil, may be also present in small quantities in DNA. A set of ten-eleven translocation (TET) proteins are involved in oxidation of 5-methylcytosine to 5-hydroxymethylcytosine which can be further oxidized to 5-formylcytosine and 5-carboxycytosine...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192139/vitamin-c-down-regulate-apo-a-expression-via-tet2-dependent-dna-demethylation-in-hepg2-cells
#7
Kai Qu, Xiao-Feng Ma, Guo-Hua Li, Hai Zhang, Ya-Mi Liu, Kai Zhang, Jun-Fa Zeng, Jian-Jun Lei, Dang-Heng Wei, Zuo Wang
Lipoprotein(a)[Lp(a)] is a risk factor for coronary heart diseases. However, the metabolism of this protein remains poorly understood. Efficient and specific drugs that can decrease high plasma levels of Lp(a) have not been developed yet. Vitamin C is responsible for maintaining the catalytic activity of a group of iron and 2-oxoglutarate (2OG)-dependent dioxygenases and induces the generation of 5-hydroxymethylcytosine (5hmC) via Ten-eleven translocation (Tet) dioxygenases. In addition, It has been reported vitamin C deficiency induces atherosclerosis and increases Lp(a) and apo(a) plasma levels in Lp(a)+ mice...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28192098/anti-leukemic-effects-of-hdaci-belinostat-and-hmti-3-deazaneplanocin-a-on-human-acute-promyelocytic-leukemia-cells
#8
Giedrė Valiulienė, Ieva Stirblytė, Monika Jasnauskaitė, Veronika Borutinskaitė, Rūta Navakauskienė
Development of acute myeloid leukemia is usually sustained by deregulated epigenome. Alterations in DNA methylation and histone modifications are common manifestations of the disease. Acute promyelocytic leukemia (APL) is not an exception. Therefore, drugs that target epigenetic processes suggest an appealing strategy for APL treatment. In this study we tested the anti-leukemic activity of histone deacetylase inhibitor (HDACi) Belinostat (PXD101, (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide), and histone methyltransferase inhibitor (HMTi) 3-Deazaneplanocin A (DZNep, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol) combined with retinoic acid (RA) in APL cells NB4 and HL-60...
February 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28185456/utilization-of-a-trimethylsilyl-group-as-a-synthetic-equivalent-of-a-hydroxyl-group-via-chemoselective-c-sp3-h-borylation-at-the-methyl-group-on-silicon
#9
Takeru Torigoe, Toshimichi Ohmura, Michinori Suginome
A conversion of trimethylsilylalkanes into the corresponding alcohols is established based on an iridium-catalyzed, chemoselective C(sp3)-H borylation of the methyl group on silicon. The (borylmethyl)silyl group formed by C(sp3)-H borylation is treated with H2O2/NaOH, and the resulting (hydroxymethyl)silyl group is converted into a hydroxyl group by Brook rearrangement, followed by oxidation of the resulting methoxysilyl group under Tamao conditions. An alternative route proceeding through the formylsilyl group formed from a (hydroxymethyl)silyl group by Swern oxidation is also established...
February 10, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28182160/curcumin-coordinated-nanoparticles-with-improved-stability-for-reactive-oxygen-species-responsive-drug-delivery-in-lung-cancer-therapy
#10
Cheng-Qiong Luo, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Bao-An Chen, Liang Jin, Hu-Lin Jiang
BACKGROUND: The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. MATERIALS AND METHODS: We synthesized a highly biocompatible 4-(hydroxymethyl) phenylboronic acid (HPBA)-modified poly(ethylene glycol) (PEG)-grafted poly(acrylic acid) polymer (PPH) and fabricated a Cur-coordinated ROS-responsive nanoparticle (denoted by PPHC) based on the interaction between boronic acid and Cur...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28181397/b-c6-f5-3-catalyzed-chemoselective-defunctionalization-of-ether-containing-primary-alkyl-tosylates-with-hydrosilanes
#11
Indranil Chatterjee, Digvijay Porwal, Martin Oestreich
Catalytic C(sp(3) )-O bond cleavage promoted by B(C6 F5 )3  /Et3 SiH proceeds preferentially with primary tosylates in the presence of primary and secondary silyl ethers and aryl ethers. This reactivity difference enables the chemoselective defunctionalization of several 1,n-diols, and the efficiency of the new procedure is highlighted by the selective deoxygenation of the hydroxymethyl group of an orthogonally protected carbohydrate. Tosylates with an adjacent phenyl group are cleaved with anchimeric assistance...
February 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28178884/improved-post-thaw-function-and-epigenetic-changes-in-mesenchymal-stromal-cells-cryopreserved-using-multicomponent-osmolyte-solutions
#12
Kathryn Pollock, Rebekah Samsonraj, Amel Dudakovic, Roman Thaler, Aron Stumbras, David McKenna, Peter Dosa, Andre van Wijnen, Allison Hubel
Current methods for freezing mesenchymal stromal cells (MSCs) result in poor post-thaw function, which limits the clinical utility of these cells. This investigation develops a novel approach to preserve MSCs using combinations of sugars, sugar alcohols and small molecule additives. MSCs frozen using these solutions exhibit improved post-thaw attachment and a more normal alignment of the actin cytoskeleton compared to cells exposed to dimethylsulfoxide (DMSO). Osteogenic and chondrogenic differentiation assays show that cells retain their mesenchymal lineage properties...
February 8, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28176928/n-3-hydroxymethyl-%C3%AE-carboline-1-yl-ethyl-2-yl-l-phe-development-toward-a-nanoscaled-antitumor-drug-capable-of-treating-complicated-thrombosis-and-inflammation
#13
Jianhui Wu, Ming Zhao, Yuji Wang, Yaonan Wang, Haimei Zhu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, Shiqi Peng
It is well documented that the surfaces of cancer cells, activated platelets and inflammatory cells are rich in P-selectin. N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-l-Phe (HMCEF) is a P-selectin inhibitor capable of simultaneously inhibiting thrombosis and inflammation. Based on the knowledge that P-selectin is a common target for antithrombotic, anti-inflammatory and antitumor drugs, the aim of this study article was to estimate the possibility of HMCEF as a nanoscaled antitumor drug. Images of transmission electron micro scopy, scanning electron microscopy and atomic force microscopy proved that HMCEF forms nanoparticles with a diameter of <120 nm that promote delivery in blood circulation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28175302/assessment-of-one-step-versus-sequential-embryo-culture-conditions-through-embryonic-genome-methylation-and-hydroxymethylation-changes
#14
J Salvaing, N Peynot, M N Bedhane, S Veniel, E Pellier, C Boulesteix, N Beaujean, N Daniel, V Duranthon
No abstract text is available yet for this article.
February 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28173181/the-fmr1-promoter-is-selectively-hydroxymethylated-in-primary-neurons-of-fragile-x-syndrome-patients
#15
Rustam Esanov, Nadja S Andrade, Sarah Bennison, Claes Wahlestedt, Zane Zeier
No abstract text is available yet for this article.
November 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28168235/the-use-of-tris-hydroxymethyl-aminomethane-in-the-emergency-department
#16
Christina Lu, Evan Leibner, Brian Wright
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28160162/isolation-identification-and-differentiation-of-campylobacter-spp-using-multiplex-pcr-assay-from-goats-in-khartoum-state-sudan
#17
Atif Elbrissi, Y A Sabeil, Khalda A Khalifa, Khalid Enan, Osama M Khair, A M El Hussein
The aim of this study was to identify and characterize thermophilic Campylobacter species in faecal samples from goats in Khartoum State, Sudan, by application of multiplex polymerase chain reaction. Campylobacteriosis is a zoonotic disease of global concern, and the organisms can be transmitted to human via food, water and through contact with farm animals and pets. There are five clinically related Campylobacter species: Campylobacter jejuni (C. jejuni). Campylobacter coli, Campylobacter lari, Campylobacter upsaliensis and Campylobacter fetus...
February 4, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28156113/origin-of-the-regioselectivity-in-the-aldol-condensation-between-hydroxymethylfurfural-and-levulinic-acid-a-dft-investigation
#18
Liwei Zhao, Nnenna Elechi, Richard Qian, Timila B Singh, Ananda S Amarasekara, Hua-Jun Fan
Our previous work demonstrated that hydroxide ion (OH-) was able to catalyze aldol condensation reaction at room temperature between 5-hydroxymethylfurfural (HMF) and levulinic acid (LA). This work identified three primary reaction steps in this condensation reaction using density functional theory (DFT): (1) deprotonation of LA to generate LA ions, (2) LA ions addition at hydroxymethyl site of HMF, and (3) internal dehydration to form the condensation product. The reaction pathway through the C5 of LA forms a linear product that is both energy and configuration favored in the all three elementary reaction steps...
February 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28153600/role-of-oxidative-stress-and-dna-hydroxymethylation-in-the-neurotoxicity-of-fine-particulate-matter
#19
Hongying Wei, Yan Feng, Fan Liang, Wei Cheng, Xiaomeng Wu, Ren Zhou, Yan Wang
Epidemiological studies have implicated fine particulate matter (PM2.5) as a risk factor for neurodegenerative diseases and neurodevelopmental disorders. However, the underlying molecular mechanisms and the influences of different components remain largely elusive. Here, we extended our previous work to investigate the role of oxidative stress and DNA hydroxymethylation in neuronal pathology of PM2.5. We found PM2.5 and its extracts (water-soluble extracts, organic extracts and carbon core component) differentially caused cell cycle arrest, cell apoptosis and the cell proliferation inhibition in neuronal cells...
January 30, 2017: Toxicology
https://www.readbyqxmd.com/read/28149179/characteristics-of-antibacterial-molecular-activities-in-poplar-wood-extractives
#20
Wanxi Peng, Dongli Li, Minglong Zhang, Shengbo Ge, Bo Mo, Shasha Li, Makoto Ohkoshi
As one of the dominant plantations in north and central China, poplar was considered as the uppermost wood raw materials, however, the chemical constituents of poplar wood weren't effectively used by high added value. Therefore, the molecules of wood extractives in Populus lasiocarpa and Populus tomentosa were extracted and studied to further utilize the bio-resources. The results showed that the LD-010, LD-021, LD-150, LD-174 wood extractives were identified as having 3, 24, 3 27 components, respectively. P...
February 2017: Saudi Journal of Biological Sciences
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