keyword
MENU ▼
Read by QxMD icon Read
search

Hydroxymethylation

keyword
https://www.readbyqxmd.com/read/28821056/fabrication-of-salecan-poly-amps-co-hmaa-semi-ipn-hydrogels-for-cell-adhesion
#1
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and has excellent physicochemical and biological properties. A series of hydrogels were fabricated from Salecan and poly(2-acrylamido-2-methylpropanesulfonic acid-co-N-hydroxymethyl acrylamide) (poly(AMPS-co-HMAA), PAH) by semi-IPN technique. The introduction of Salecan into the PAH network endows the system with enhanced cell adhesion properties. These semi-IPN hydrogels with open interconnected pores had pH and salt-sensitive swelling behavior. The increase in the content of hydrophilic Salecan could enhance the water uptake of the hydrogels...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28816445/tracking-the-progress-and-mechanism-study-of-a-solvothermal-in-situ-domino-n-alkylation-reaction-of-triethylamine-and-ammonia-assisted-by-ferrous-sulfate
#2
Jin-Ping Zhong, Bin Liu, Tao Yang, Yue-Jin Liu, Zhong-Hong Zhu, Bing-Feng Shi, Mohamedally Kurmoo, Ming-Hua Zeng
Atom economic in situ domino N-alkylation reactions of triethylamine/ammonia with 2-(hydroxymethyl)quinolin-8-ol (HL-OH) assisted by FeSO4·7H2O were realized under mild solvothermal conditions at 120 °C in acetonitrile. The resulting tripodal 2,2',2″-[nitrilotris(methylene)]tris(quinolin-8-ol) (H3L3-N) forms a linear trimer [Fe3(L3-N)2] (1). Electrospray ionization mass spectrometry of the reaction solution provides evidence for the intermediates of three steps, while crystallography and X-ray photoelectron spectroscopy characterize the trimer...
August 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28815216/epistatic-interactions-within-the-influenza-a-virus-polymerase-complex-mediate-mutagen-resistance-and-replication-fidelity
#3
Matthew D Pauly, Daniel M Lyons, William J Fitzsimmons, Adam S Lauring
Lethal mutagenesis is a broad-spectrum antiviral strategy that employs mutagenic nucleoside analogs to exploit the high mutation rate and low mutational tolerance of many RNA viruses. Studies of mutagen-resistant viruses have identified determinants of replicative fidelity and the importance of mutation rate to viral population dynamics. We have previously demonstrated the effective lethal mutagenesis of influenza A virus using three nucleoside analogs as well as the virus's high genetic barrier to mutagen resistance...
July 2017: MSphere
https://www.readbyqxmd.com/read/28809103/a-chiral-pedot-based-enantioselective-electrode-modification-material-for-chiral-electrochemical-sensing-mechanism-and-model-of-chiral-recognition
#4
Liqi Dong, Youshan Zhang, Xuemin Duan, Xiaofei Zhu, Hui Sun, Jingkun Xu
The development of electrochemical methods for enantioselective recognition is a focus of research in pharmaceuticals and biotechnology. In this study, a pair of water-soluble chiral 3,4-ethylenedioxythiophene (EDOT) derivatives-(R)-2'-hydroxymethyl-3,4-ethylenedioxythiophene ((R)-EDTM) and (S)-2'-hydroxymethyl-3,4-ethylenedioxythiophene ((S)-EDTM)-were synthesized and electrodeposited on the surface of a glassy carbon electrode (GCE) via current-time (I-t) polymerization in an aqueous LiClO4 electrolyte. These chiral PEDOT polymers were used to fabricate chiral sensors and to investigate the enantioselective recognition of D-/L-3,4-dihydroxyphenylalanine, D-/L-tryptophan and (R)-/(S)-propranolol enantiomers, respectively...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28805226/the-reaction-of-criegee-intermediate-ch2oo-with-water-dimer-primary-products-and-atmospheric-impact
#5
Leonid Sheps, Brandon Rotavera, Arkke J Eskola, David L Osborn, Craig A Taatjes, Kendrew Au, Dudley E Shallcross, M Anwar H Khan, Carl J Percival
The rapid reaction of the smallest Criegee intermediate, CH2OO, with water dimers is the dominant removal mechanism for CH2OO in the Earth's atmosphere, but its products are not well understood. This reaction was recently suggested as a significant source of the most abundant tropospheric organic acid, formic acid (HCOOH), which is consistently underpredicted by atmospheric models. However, using time-resolved measurements of reaction kinetics by UV absorption and product analysis by photoionization mass spectrometry, we show that the primary products of this reaction are formaldehyde and hydroxymethyl hydroperoxide (HMHP), with direct HCOOH yields of less than 10%...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28805046/electroenhanced-antimicrobial-coating-based-on-conjugated-polymers-with-covalently-coupled-silver-nanoparticles-prevents-staphylococcus-aureus-biofilm-formation
#6
Salvador Gomez-Carretero, Rolf Nybom, Agneta Richter-Dahlfors
The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28804002/a-novel-glycoside-hydrolase-family-97-enzyme-bifunctional-%C3%AE-l-arabinopyranosidase-%C3%AE-galactosidase-from-bacteroides-thetaiotaomicron
#7
Asako Kikuchi, Masayuki Okuyama, Koji Kato, Shohei Osaki, Min Ma, Yuya Kumagai, Kana Matsunaga, Patcharapa Klahan, Takayoshi Tagami, Min Yao, Atsuo Kimura
Glycoside hydrolase family 97 (GH97) is one of the most interesting glycosidase families, which contains inverting and retaining glycosidases. Currently, only two enzyme types, α-glucoside hydrolase and α-galactosidase, are registered in the carbohydrate active enzyme database as GH97 function-known proteins. To explore new specificities, BT3661 and BT3664, which have distinct amino acid sequences when compared with that of GH97 α-glucoside hydrolase and α-galactosidase, were characterized in this study...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28797770/replacement-of-benzylic-hydroxy-group-by-vinyl-or-hydroxymethyl-moiety-at-the-3-benzazepine-scaffold-retaining-glun2b-affinity
#8
Susann Rath, Dirk Schepmann, Bernhard Wünsch
Since overactivation of NMDA receptors is associated with neurodegenerative disorders, the design and development of subunit-selective NMDA receptor antagonists are of great interest. In order to avoid the formation of quinone-like intermediates as starting point for degradation the benzylic OH group of the lead compounds 2 was replaced by an electron rich vinyl or homologous hydroxymethyl moiety. The Bi(OTf)3 catalyzed intramolecular Friedel-Crafts alkylation of 9a represents the key step in the synthesis of 1-vinyl substituted tetrahydro-3-benzazepine 10...
July 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28795802/covalent-synthesis-of-two-hybrids-composed-of-dawson-type-polyoxometalate-and-porphyrin-with-remarkable-third-order-optical-nonlinearities-reflecting-the-effect-of-polyoxometalates
#9
Hafiz Muhammad Asif, Yunshan Zhou, Lijuan Zhang, Nusrat Shaheen, Di Yang, Jiaqi Li, Yi Long, Arshad Iqbal, Yanqin Li
Two new porphyrin-polyoxometalate hybrids, namely, [(C4H9)4N]10H2[{COHNC(CH2O)3P2V3W15O59}2C44N4H28]·CH3CN 1, bearing two covalent-bonded Wells-Dawson-type polyoxometalates (POMs), and [(C4H9)4N)]5H[COHNC(CH2O)3P2V3W15O59{C44H29N4}]·CH3CN 2, bearing one covalent-bonded POM, have been synthesized and thoroughly characterized by means of elemental analysis, powder XRD, FT-IR, (1)H ((31)P, (51)V) NMR, MALDI-TOF-MS, UV-vis spectra, and cyclic voltammetry measurement. Experimental results demonstrate that while all the compounds show remarkable third-order optical nonlinearities, the hybrids 1 and 2 are superior to their corresponding porphyrin precursors (molecular second hyperpolarizability γ = 8...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28795592/semi-synthetic-thymoquinone-analogs-new-prototypes-as-potential-antihyperlipidemics-in-irradiated-rats
#10
Nashwa H Zaher, Engy R Rashed, Mona A El-Ghazaly
AIM: Thymoquinone (TQ), has been reported to possess strong antihyperlipidemic properties. However, a variety of serious side effects has been reported for TQ. The present study aimed to evaluate the potential antihyperlipidemic activity of newly synthesized TQ analogs. METHODS & RESULTS: first, novel TQ derivatives were studied against radiation-induced dyslipidemia in male rats. Second, the most promising sulfur derivatives (4-7), were further tested to elucidate their possible mechanism(s) of actions...
August 10, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28794029/coordinate-regulation-of-tet2-and-ebna2-control-dna-methylation-state-of-latent-epstein-barr-virus
#11
Fang Lu, Andreas Wiedmer, Kayla A Martin, Priyankara J M S Wickramasinghe, Andrew V Kossenkov, Paul M Lieberman
Epstein-Barr Virus (EBV) latency and its associated carcinogenesis are regulated by dynamic changes in DNA methylation of both virus and host genomes. We show here that the Ten-Eleven Translocation 2 (TET2) gene, implicated in hydroxymethylation and active DNA demethylation, is a key regulator of EBV latency type DNA methylation patterning. EBV latency types are defined by DNA methylation patterns that restrict expression of viral latency genes. We show that TET2 mRNA and protein expression correlate with the highly demethylated EBV type III latency program permissive for expression of EBNA2, EBNA3s, and LMP transcripts...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28769976/new-insights-into-5hmc-dna-modification-generation-distribution-and-function
#12
REVIEW
Dong-Qiao Shi, Iftikhar Ali, Jun Tang, Wei-Cai Yang
Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In addition to the common methylation on the 5th position of the pyrimidine ring of cytosine (5mC), other types of modifications at the same position, such as 5-hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5caC), are also important. Recently, 5hmC, a product of 5mC demethylation by the Ten-Eleven Translocation family proteins, was shown to regulate many cellular and developmental processes, including the pluripotency of embryonic stem cells, neuron development, and tumorigenesis in mammals...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28768421/constituents-from-solid-cultured-antrodia-camphorata
#13
Zong-Bo Tong, Xu-Hong Cui, Jie Wang, Cun-Li Zhang, Yan-Yan Zhang, Zhan-Jun Ren
Antrodia camphorata is a rare and precious traditional food and medicine for improving health-related conditions in Taiwan. The phytochemical research of the mushroom led to the isolation of a new naphthalenecarboxaldehyde, named as 1-Naphthalenecarboxaldehyde,3,4,4a,5,6,7,8,8a-octahydro-2-(hydroxymethyl)-5,5,8a-trimethyl (1). Meanwhile, seven other known compounds of nerolidol (2), cadinol (3), herbarulide (4), 3β-Hydroxy-5a,8a-epidioxyergosta-6,22-diene (5), ergosta-7,22-diene-3,6-dione (6) 2,3-dimethoxy-5-methyl-p-benzoquinone (7) and β-sitosterol (8) were also obtained from A...
August 2, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28763772/ph-responsive-chitosan-nanoparticles-from-a-novel-twin-chain-anionic-amphiphile-for-controlled-and-targeted-delivery-of-vancomycin
#14
Rahul S Kalhapure, Mahantesh Jadhav, Sanjeev Rambharose, Chunderika Mocktar, Sanil Singh, Jwala Renukuntla, Thirumala Govender
The design and synthesis of novel pH-responsive nanoantibiotics is an emerging research area to address the antibiotic resistance crisis. The purpose of this study was therefore to synthesize a new anionic gemini surfactant (AGS) that could result in the formulation of pH-responsive chitosan nanoparticles (CSNPs) to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. The coupling of oleic acid with 2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane and subsequent deprotection followed by a reaction with succinic anhydride and sodium bicarbonate yielded AGS...
July 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28762673/interaction-between-maternal-and-paternal-shmt1-c1420t-predisposes-to-neural-tube-defects-in-the-fetus-evidence-from-case-control-and-family-based-triad-approaches
#15
Prasoona K Rebekah, Sunitha Tella, Srinadh Buragadda, Muni Kumari Tiruvatturu, Jyothy Akka
BACKGROUND: Neural tube defects (NTDs) are caused by the failure of neural tube formation which occurs during early embryonic development. NTDs are the most severe and leading cause of fetal mortality. Serine hydroxymethyl transferase (SHMT1) provides one-carbon units necessary for embryogenesis and defects in one-carbon production result in specific pathological conditions during pregnancy. The present study is aimed to evaluate the association of SHMT1 C1420T with NTD risk in the fetus using fetal, maternal and paternal groups by applying both case-control and family-based triad approaches...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28759814/evaluation-of-hydrogen-bond-networks-in-cellulose-i%C3%AE-and-ii-crystals-using-density-functional-theory-and-car-parrinello-molecular-dynamics
#16
Daichi Hayakawa, Yoshiharu Nishiyama, Karim Mazeau, Kazuyoshi Ueda
Crystal models of cellulose Iβ and II, which contain various hydrogen bonding (HB) networks, were analyzed using density functional theory and Car-Parrinello molecular dynamics (CPMD) simulations. From the CPMD trajectories, the power spectra of the velocity correlation functions of hydroxyl groups involved in hydrogen bonds were calculated. For the Iβ allomorph, HB network A, which is dominant according to the neutron diffraction data, was stable, and the power spectrum represented the essential features of the experimental IR spectra...
July 5, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28759206/electronic-effect-of-ruthenium-nanoparticles-on-efficient-reductive-amination-of-carbonyl-compounds
#17
Tasuku Komanoya, Takashi Kinemura, Yusuke Kita, Keigo Kamata, Michikazu Hara
Highly selective synthesis of primary amines over heterogeneous catalysts is still a challenge for the chemical industry. Ruthenium nanoparticles supported on Nb2O5 act as a highly selective and reusable heterogeneous catalyst for the low-temperature reductive amination of various carbonyl compounds that contain reduction-sensitive functional groups such as heterocycles and halogens with NH3 and H2 and prevent the formation of secondary amines and undesired hydrogenated byproducts. The selective catalysis of these materials is likely attributable to the weak electron-donating capability of Ru particles on the Nb2O5 surface...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28758896/chemo-brain-or-tumor-brain-that-is-the-question-the-presence-of-extracranial-tumors-profoundly-affects-molecular-processes-in-the-prefrontal-cortex-of-tumorgraft-mice
#18
Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Amanda Katz, David Sidransky, Olga Kovalchuk, Bryan Kolb
Cancer chemotherapy causes numerous persistent central nervous system complications. This condition is known as chemo brain. Cognitive impairments occur even before treatment, and hence are referred to as cancer associated cognitive changes, or tumor brain. There is much yet to be learned about the mechanisms of both chemo brain and tumor brain. The frequency and timing of chemo brain and tumor brain occurrence and persistence strongly suggest they may be epigenetic in nature and associated with altered gene expression...
July 29, 2017: Aging
https://www.readbyqxmd.com/read/28752763/polyhydroxylated-quinolizidine-iminosugars-as-nanomolar-selective-inhibitors-of-%C3%AE-glucosidases
#19
Anais Vieira Da Cruz, Alice Kanazawa, Jean-François Poisson, Jean-Bernard Behr, Sandrine Py
Polyhydroxylated quinolizidines bearing a hydroxymethyl group at the ring junction were synthesized from a readily available L-sorbose-derived ketonitrone. Evaluated as glycoside hydrolase inhibitors, these quinolizidines revealed to be potent and selective α-glucosidase inhibitors. Quinolizidine 9a is the first quinolizidine-scaffolded iminosugar exhibiting nanomolar inhibition of a glycoenzyme.
July 28, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28752494/epigenetics-in-sle
#20
REVIEW
Christian Michael Hedrich
PURPOSE OF REVIEW: Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of clinically evident disease. RECENT FINDINGS: Over the past decade, epigenetic events moved into the focus of research targeting the molecular pathophysiology of SLE...
September 2017: Current Rheumatology Reports
keyword
keyword
7181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"