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https://www.readbyqxmd.com/read/27878290/-oleocanthal-exerts-anti-melanoma-activities-and-inhibits-stat3-signaling-pathway
#1
Yanli Gu, Jing Wang, Lixin Peng
Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addition, OC inhibited proliferation, migration, invasion and tube formation in human umbilical vascular endothelial cells. In vivo, it exhibited potent activity in suppressing tumor growth in a subcutaneous xenograft model...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27713961/anti-cancer-properties-of-olive-oil-secoiridoid-phenols-a-systematic-review-of-in-vivo-studies
#2
R Fabiani
Epidemiological studies suggest that olive oil intake is associated to a reduced risk of cancer. Recently, the chemopreventive activity of olive oil has been attributed to its unique phenolic compounds represented by phenolic alcohols, hydroxytyrosol (3,4-dihydroxyphenylethanol: 3,4-DHPEA) and tyrosol (p-hydroxyphenylethanol: p-HPEA), and their secoiridoid derivatives 3,4-DHPEA-EA (oleuropein aglycon), p-HPEA-EA (ligstroside aglycon), 3,4-DHPEA-EDA, p-HPEA-EDA (oleocanthal), and oleuropein. Several studies have demonstrated that these compounds are able to inhibit proliferation and induce apoptosis in different tumor cell lines...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27266366/cytotoxic-activity-of-oleocanthal-isolated-from-virgin-olive-oil-on-human-melanoma-cells
#3
Stefano Fogli, Chiara Arena, Sara Carpi, Beatrice Polini, Simone Bertini, Maria Digiacomo, Francesca Gado, Alessandro Saba, Giuseppe Saccomanni, Maria Cristina Breschi, Paola Nieri, Clementina Manera, Marco Macchia
Oleocanthal is one of the phenolic compounds of extra virgin olive oil with important anti-inflammatory properties. Although its potential anticancer activity has been reported, only limited evidence has been provided in cutaneous malignant melanoma. The present study is aimed at investigating the selective in vitro antiproliferative activity of oleocanthal against human malignant melanoma cells. Since oleocanthal is not commercially available, it was obtained as a pure standard by direct extraction and purification from extra virgin olive oil...
July 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27259268/-oleocanthal-inhibits-growth-and-metastasis-by-blocking-activation-of-stat3-in-human-hepatocellular-carcinoma
#4
Tiemin Pei, Qinghui Meng, Jihua Han, Haobo Sun Long Li, Ruipeng Song, Boshi Sun, Shangha Pan, Desen Liang, Lianxin Liu
We explored the anti-cancer capacity of (-)-oleocanthal in human hepatocellular carcinoma (HCC). (-)-Oleocanthal inhibited proliferation and cell cycle progression and induced apoptosis in HCC cells in vitro and suppressed tumor growth in an orthotopic HCC model. (-)-Oleocanthal also inhibited HCC cell migration and invasion in vitro and impeded HCC metastasis in an in vivo lung metastasis model. ( )-Oleocanthal acted by inhibiting epithelial-mesenchymal transition (EMT) through downregulation Twist, which is a direct target of STAT3...
June 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27258622/novel-c-met-inhibitory-olive-secoiridoid-semisynthetic-analogs-for-the-control-of-invasive-breast-cancer
#5
Mohamed M Mohyeldin, Belnaser A Busnena, Mohamed R Akl, Ana Maria Dragoi, James A Cardelli, Khalid A El Sayed
Dysregulated receptor tyrosine kinase c-Met and its ligand HGF is valid and attractive molecular target for therapeutic blockade in cancer. Inspired by the chemical structure of the naturally occurring olive secoiridoid (-)-oleocanthal (1) and its documented anticancer activity against c-Met-dependent malignancies, a previous study reported tyrosol sinapate (4) as a c-Met inhibitor hit. This study reports additional semisynthetic optimization and SAR of 4 to improve its selective activity against c-Met-dependent breast cancer by increasing its capacity to inhibit c-Met phosphorylation...
April 20, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27086914/the-oleocanthal-based-homovanillyl-sinapate-as-a-novel-c-met-inhibitor
#6
Mohamed M Mohyeldin, Mohamed R Akl, Hassan Y Ebrahim, Ana Maria Dragoi, Samantha Dykes, James A Cardelli, Khalid A El Sayed
The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) signaling axis has gained considerable attention as an attractive molecular target for therapeutic blockade of cancer. Inspired by the chemical structure of S (-)-oleocanthal, a natural secoiridoid from extra-virgin olive oil with documented anticancer activity against c-Met-dependent malignancies, the research presented herein reports on the discovery of the novel olive-derived homovanillyl sinapate (HVS) as a promising c-Met inhibitor...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/26841137/oil-quality-parameters-and-quantitative-measurement-of-major-secoiridoid-derivatives-in-neb-jmel-olive-oil-from-various-tunisian-origins-using-qnmr
#7
Amir Ben Mansour, Boutheina Gargouri, Eleni Melliou, Prokopios Magiatis, Mohamed Bouaziz
BACKGROUND: Olive oil contains compounds with interesting biological activities which are influenced by the cultivar, the geographic origin and other factors. The aims of this work were to (1) investigate these factors in Neb Jmel olive oil from various Tunisian origins; (2) determine the influence of geographic conditions on phenolic composition of Neb Jmel olive oil and consequently on the antioxidant compounds; and (3) verify whether oils could be discriminated based on geographical origin...
October 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/26654091/quantity-and-quality-of-secoiridoids-and-lignans-in-extra-virgin-olive-oils-the-effect-of-two-and-three-way-decanters-on-leccino-and-raggiola-olive-cultivars
#8
Elena Antonini, Alfonso Farina, Emanuele Salvatore Scarpa, Alessandra Frati, Paolino Ninfali
In this investigation, 14 extra virgin olive oils (EVOOs), produced with Leccino and Raggiola olive cultivars, by a new two-way (2W) decanter were compared with 14 EVOOs produced by means of a conventional three-way (3W) decanter. The 2W EVOOs had higher phenol concentrations, as shown by high-performance liquid chromatography/diode array detection (HPLC-DAD) analysis and yielded a higher extraction of the 3,4-DHPEA-EDA (oleacein), 3,4-DHPEA-EA (oleuropein aglycone) and p-HPEA-EDA (oleocanthal). The concentrations of lignans, (+)-pinoresinol and (+)-1-acetoxypinoresinol, detected by HPLC-FLD equipment, were higher in the 2W EVOOs than they were in EVOOs produced using the 3W system...
2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/26616988/extraction-of-phenolic-compounds-from-virgin-olive-oil-by-deep-eutectic-solvents-dess
#9
Aránzazu García, Elisa Rodríguez-Juan, Guillermo Rodríguez-Gutiérrez, José Julian Rios, Juan Fernández-Bolaños
Deep eutectic solvents (DESs) are "green" solvents, applied in this study for the extraction of phenolic compounds from virgin olive oil (VOO). Different combinations of DES consisting of choline chloride (ChCl) in various mixing ratios with sugars, alcohols, organic acids, and urea, as well as a mixture of three sugars were used. The yields of the DES extractions were compared with those from conventional 80% (v/v) methanol/water. DES showed a good solubility of phenolic compounds with different polarities...
April 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26380379/-oleocanthal-rapidly-and-selectively-induces-cancer-cell-death-via-lysosomal-membrane-permeabilization
#10
Onica LeGendre, Paul As Breslin, David A Foster
(-)-Oleocanthal (OC), a phenolic compound present in extra-virgin olive oil (EVOO), has been implicated in the health benefits associated with diets rich in EVOO. We investigated the effect of OC on human cancer cell lines in culture and found that OC induced cell death in all cancer cells examined as rapidly as 30 minutes after treatment in the absence of serum. OC treatment of non-transformed cells suppressed their proliferation but did not cause cell death. OC induced both primary necrotic and apoptotic cell death via induction of lysosomal membrane permeabilization (LMP)...
2015: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/26348065/oleocanthal-enhances-amyloid-%C3%AE-clearance-from-the-brains-of-tgswdi-mice-and-in-vitro-across-a-human-blood-brain-barrier-model
#11
Hisham Qosa, Yazan S Batarseh, Mohamed M Mohyeldin, Khalid A El Sayed, Jeffrey N Keller, Amal Kaddoumi
Numerous clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO) that could protect and decrease the risk of developing Alzheimer's disease (AD). Moreover, recent studies have linked this protective effect to oleocanthal, a phenolic secoiridoid component of EVOO. This protective effect of oleocanthal against AD has been related to its ability to prevent amyloid-β (Aβ) and tau aggregation in vitro, and enhance Aβ clearance from the brains of wild type mice in vivo; however, its effect in a mouse model of AD is not known...
November 18, 2015: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/26248874/olive-oil-derived-oleocanthal-as-potent-inhibitor-of-mammalian-target-of-rapamycin-biological-evaluation-and-molecular-modeling-studies
#12
Mohammad A Khanfar, Sanaa K Bardaweel, Mohamed R Akl, Khalid A El Sayed
The established anticancer and neuroprotective properties of oleocanthal combined with the reported role of mammalian target of rapamycin (mTOR) in cancer and Alzheimer's disease development encouraged us to examine the possibility that oleocanthal inhibits mTOR. To validate this hypothesis, we docked oleocanthal into the adenosine triphosphate binding pocket of a close mTOR protein homologue, namely, PI3K-γ. Apparently, oleocanthal shared nine out of ten critical binding interactions with a potent dual PIK3-γ/mTOR natural inhibitor...
November 2015: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26197539/in-cell-interactome-of-oleocanthal-an-extra-virgin-olive-oil-bioactive-component
#13
Chiara Cassiano, Agostino Casapullo, Alessandra Tosco, Maria Chiara Monti, Raffaele Riccio
A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal...
June 2015: Natural Product Communications
https://www.readbyqxmd.com/read/26166135/oleocanthal-modulates-estradiol-induced-gene-expression-involving-estrogen-receptor-%C3%AE
#14
Annekathrin Martina Keiler, Sefirin Djiogue, Tino Ehrhardt, Oliver Zierau, Leandros Skaltsounis, Maria Halabalaki, Günter Vollmer
Oleocanthal is a bioactive compound from olive oil. It has attracted considerable attention as it is anti-inflammatory, antiproliferative, and has been shown to possess neuroprotective properties in vitro and in vivo. Delineated from its polyphenolic structure, the aim of this study was to characterize oleocanthal towards estrogenic properties. This might contribute to partly explain the beneficial effects described for the Mediterranean diet. Estrogenic properties of oleocanthal were assessed by different methods: a) stimulation of reporter gene activity in MVLN or RNDA cells either expressing estrogen receptor α or β, b) stimulation of luciferase reporter gene activity in U2OS osteosarcoma cells expressing estrogen receptor α or β, and c) elucidation of the impact on estradiol-induced gene expression in U2OS cells transduced with both estrogen receptors...
September 2015: Planta Medica
https://www.readbyqxmd.com/read/26092624/olive-oil-phenols-as-promising-multi-targeting-agents-against-alzheimer-s-disease
#15
REVIEW
Stefania Rigacci
Amyloid diseases are characterized by the deposition of typically aggregated proteins/peptides in tissues, associated with degeneration and progressive functional impairment. Alzheimer's disease is one of the most studied neurodegenerative amyloid diseases and, in Western countries, a significant cause of dementia in the elderly. The so-called "Mediterranean diet" has been considered for long as the healthier dietary regimen, characterised by a great abundance in vegetables and fruits, extra virgin olive oil as the main source of fat, a moderate consumption of red wine and a reduced intake of proteins from red meat...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25922082/actions-of-adjunctive-nutritional-antioxidants-in-periodontitis-and-prevalent-systemic-inflammatory-diseases
#16
U El-Shinnawi, M Soory
Common risk markers for periodontitis and prevalent systemic comorbidities indicate similarities in their progression and molecular mechanisms involved. Resultant pro-oxidant disease profiles provide scope for attenuating their pathogeneses with appropriate adjunctive antioxidants. Levels of oxidative stress markers 8-hydroxy-deoxguanosine (8-HOdG) and malondialdehyde (MDA) are significantly higher in periodontitis and other chronic inflammatory conditions. There is a clear link between periodontitis and diseases associated with significant systemic inflammatory loading, such as metabolic syndrome...
2015: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/25781069/potential-role-of-olive-oil-phenolic-compounds-in-the-prevention-of-neurodegenerative-diseases
#17
REVIEW
Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/25448758/new-drugs-from-ancient-natural-foods-oleocanthal-the-natural-occurring-spicy-compound-of-olive-oil-a-brief-history
#18
Morena Scotece, Javier Conde, Vanessa Abella, Veronica Lopez, Jesús Pino, Francisca Lago, Amos B Smith, Juan J Gómez-Reino, Oreste Gualillo
Extra-virgin olive oil (EVOO), a principal component of the Mediterranean diet (Med diet), is one of the most ancient known foods and has long been associated with health benefits. Many phenolic compounds extracted from Olea europea L. have attracted attention since their discovery. Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseases, showing relevant pharmacological properties in various pathogenic processes, including inflammation, cancers and neurodegenerative diseases...
April 2015: Drug Discovery Today
https://www.readbyqxmd.com/read/25306330/preparative-isolation-of-oleocanthal-tyrosol-and-hydroxytyrosol-from-olive-oil-by-hpccc
#19
Hamid-Reza Adhami, Martin Zehl, Christina Dangl, Dominic Dorfmeister, Marco Stadler, Ernst Urban, Peter Hewitson, Svetlana Ignatova, Liselotte Krenn
For the provision of oleocanthal (OLC), a phenolic compound with very promising pharmacological properties, isolation from olive oil is a very important option. Due to the compound's sensitivity to decomposition upon exposure to oxygen and light, a very gentle isolation method has been developed under use of high performance countercurrent chromatography (HPCCC). By partition of olive oil between hexane and methanol, an extract enriched in phenolics was prepared and subjected to a two-step HPCCC separation under use of heptane-EtOAc-MeOH-H2O mixtures in normal-phase and reverse phase mode, respectively...
March 1, 2015: Food Chemistry
https://www.readbyqxmd.com/read/25236241/quantitative-analysis-of-pungent-and-anti-inflammatory-phenolic-compounds-in-olive-oil-by-capillary-electrophoresis
#20
Isabella Vulcano, Maria Halabalaki, Leandros Skaltsounis, Markus Ganzera
The first CE procedure for the quantitative determination of pharmacologically relevant secoiridoids in olive oil, oleocanthal and oleacein, is described. Together with their precursors tyrosol and hydroxytyrosol they could be baseline separated in less than 15min using a borax buffer with pH 9.5, at 25kV and 30°C. Method validation confirmed that the procedure is selective, accurate (recovery rates from 94.0 to 104.6%), reproducible (σmax⩽6.8%) and precise (inter-day precision⩽6.4%), and that the compounds do not degrade quickly if non-aqueous acetonitrile is used as solvent...
February 15, 2015: Food Chemistry
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