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https://www.readbyqxmd.com/read/28344094/controlled-release-of-antibiotic-amoxicillin-drug-using-carboxymethyl-cellulose-cl-poly-itaconic-acid-co-lactic-acid-hydrogel
#1
S Sood, Vinod Kumar Gupta, Shilpi Agarwal, Kamal Dev, Deepak Pathania
In this paper, microwave assisted preparation of carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) (CMC-cl-P(LA-co-IA)) hydrogel was reported via facile graft copolymerization using N, N(1)-methylene-bis-acrylamide (MBA) and potassium persulphate as cross linker and initiator. Different reaction parameters were optimized to achieve good yield. The formation of hydrogel was confirmed by characterization techniques such as Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy etc...
March 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28335304/silver-nanoparticle-embedded-thin-silica-coated-graphene-oxide-as-an-sers-substrate
#2
Xuan-Hung Pham, Eunil Hahm, Hyung-Mo Kim, Seongbo Shim, Tae Han Kim, Dae Hong Jeong, Yoon-Sik Lee, Bong-Hyun Jun
A hybrid of Ag nanoparticle (NP)-embedded thin silica-coated graphene oxide (GO@SiO₂@Ag NPs) was prepared as a surface-enhanced Raman scattering (SERS) substrate. A 6 nm layer of silica was successfully coated on the surface of GO by the physical adsorption of sodium silicate, followed by the hydrolysis of 3-mercaptopropyl trimethoxysilane. Ag NPs were introduced onto the thin silica-coated graphene oxide by the reduction of Ag⁺ to prepare GO@SiO₂@Ag NPs. The GO@SiO₂@Ag NPs exhibited a 1.8-fold enhanced Raman signal compared to GO without a silica coating...
September 22, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28330475/in-memorian-thomas-w-hesterberg-phd-mba-1950-2016
#3
David B Warheit
No abstract text is available yet for this article.
March 22, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28326965/hematogones-detected-by-flow-cytometry-in-a-child-with-vitamin-b12-deficiency
#4
Lisa Sutton, Nkechi Mba
Vitamin B12 deficiency is a known cause of megaloblastic anemia and bone marrow failure. Bone marrow biopsies are not frequently performed as part of the diagnostic workup and can demonstrate morphologic features that overlap with myelodysplastic syndrome (MDS) and acute leukemia. We describe a case of a dysplastic bone marrow with increased bone marrow hematogones detected by flow cytometry in a child with vitamin B12 deficiency. Hematogones are normal B cell precursors, and hyperplasia has been described in a variety of often reactive conditions and also disease...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28324718/l-arginine-assisted-one-pot-synthesis-of-hierarchical-ag1pt2-nanocorallines-for-surface-enhanced-raman-spectroscopy
#5
Liu-Ying Jiang, Xin-Sheng Li, Ai-Jun Wang, Hong Huang, Jiu-Ju Feng
The hierarchical multi-branched Ag1Pt2 nanocorallines (NCs) were prepared in a large scale by a rapid aqueous method, using l-arginine as the eco-friendly shape-directing agent. The product was mainly characterized by microscopy measurements, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The architectures exhibited superior surface-enhanced Raman scattering (SERS) with 4-nitrothiophenol (4-NTP), the enhancement factor (EF) of 1.3×10(5), a wide linear range of 10-100μM and a low detection limit of 0...
March 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28322540/a-rapid-recovery-double-crosslinking-hydrogel-with-stable-mechanical-properties-and-high-resilience-triggered-by-visible-light
#6
Longxiang Zhu, Jianhui Qiu, Eiichi Sakai, Kazushi Ito
The designed tough hydrogels, depending on energy dissipation mechanism, possess excellent biocompatibility, stimuli-responsiveness and outstanding mechanical properties. However, the application of hydrogels are greatly limited in actuators and sensors for the lack of instantaneous recovery and resilience. In this work, we synthesized a double crosslinking polyacrylic acid hydrogel via a simple, one-pot, visible-light-trigger polymerization, where carboxymethyl cellulose as initiator and the first cross-linker, N,N'-methylene bisacrylamide (MBA) as the second cross-linker...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28282915/implementing-the-bruker-maldi-biotyper-in-the-public-health-laboratory-for-c-botulinum-neurotoxin-detection
#7
Michael J Perry, Dominick A Centurioni, Stephen W Davis, George E Hannett, Kimberlee A Musser, Christina T Egan
Currently, the gold standard method for active botulinum neurotoxin (BoNT) detection is the mouse bioassay (MBA). A Centers for Disease Control and Prevention-developed mass spectrometry (MS)-based assay that detects active BoNT was successfully validated and implemented in a public health laboratory in clinical matrices using the Bruker MALDI-TOF MS (Matrix-assisted laser desorption ionization-time of flight mass spectrometry) Biotyper. For the first time, a direct comparison with the MBA was performed to determine MS-based assay sensitivity using the Bruker MALDI Biotyper...
March 9, 2017: Toxins
https://www.readbyqxmd.com/read/28274462/extraction-of-melamine-from-milk-using-a-magnetic-molecularly-imprinted-polymer
#8
T S Anirudhan, J Christa, J R Deepa
A novel magnetic molecularly imprinted polymer (MMIP) for the preconcentration of melamine, a non-protein nitrogen food additive from complex matrices was synthesized and characterized using FT-IR, XRD, SEM and VSM techniques. Surface imprinting was done on vinyltrimethoxysilane coated Fe3O4 (Fe3O4-VTMS) using 2-acrylamido-2-methylpropane sulfonic acid (AMPS), N,N'-methylenebisacrylamide (MBA) and potassium persulfate (KPS) as functional monomer, crosslinker and initiator respectively. Saturation magnetization value obtained for MMIP was 1...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28267605/chairmen-in-academic-urologic-practice-a-descriptive-analysis
#9
Nicholas J Farber, Brian J Friel, Young S Kwon, Andrew Cruz, Sammy E Elsamra
OBJECTIVE: To examine and characterize the demographics and scholarly characteristics of academic urology chairmen at the time of appointment. METHODS: The chairman of each United States urology residency program as of September 2016 was included in the study. Interim chairmen, as well as programs for which no clearly defined chair could be identified, were excluded. Demographic and academic data were collected via publically available curriculum vitae, departmental websites, Google search engine, and PubMed and Scopus websites...
March 3, 2017: Urology
https://www.readbyqxmd.com/read/28257022/supramolecular-hydrogen-bonding-patterns-in-1-1-cocrystals-of-5-fluorouracil-with-4-methylbenzoic-acid-and-3-nitrobenzoic-acid
#10
Marimuthu Mohana, Packianathan Thomas Muthiah, Colin D McMillen
The design of a pharmaceutical cocrystal is based on the identification of specific hydrogen-bond donor and acceptor groups in active pharmaceutical ingredients (APIs) in order to choose a `complementary interacting' molecule that can act as an efficient coformer. 5-Fluorouracil (5FU) is a pyrimidine derivative with two N-H donors and C=O acceptors and shows a diversity of hydrogen-bonding motifs. Two 1:1 cocrystals of 5-fluorouracil (5FU), namely 5-fluorouracil-4-methylbenzoic acid (5FU-MBA), C4H3FN2O2·C8H8O2, (I), and 5-fluorouracil-3-nitrobenzoic acid (5FU-NBA), C4H3FN2O2·C7H5NO4, (II), have been prepared and characterized by single-crystal X-ray diffraction...
March 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28255832/analysing-algorithms-and-data-sources-for-the-tissue-specific-reconstruction-of-liver-healthy-and-cancer-cells
#11
Jorge Ferreira, Sara Correia, Miguel Rocha
Genome-Scale Metabolic Models (GSMMs), mathematical representations of the cell metabolism in different organisms including humans, are resourceful tools to simulate metabolic phenotypes and understand associated diseases, such as obesity, diabetes and cancer. In the last years, different algorithms have been developed to generate tissue-specific metabolic models that simulate different phenotypes for distinct cell types. Hepatocyte cells are one of the main sites of metabolic conversions, mainly due to their diverse physiological functions...
March 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28255568/association-between-lateral-posterior-tibial-slope-body-mass-index-and-acl-injury-risk
#12
Katherine M Bojicic, Mélanie L Beaulieu, Daniel Y Imaizumi Krieger, James A Ashton-Miller, Edward M Wojtys
BACKGROUND: While body mass index (BMI), a modifiable parameter, and knee morphology, a nonmodifiable parameter, have been identified as risk factors for anterior cruciate ligament (ACL) rupture, the interaction between them remains unknown. An understanding of this interaction is important because greater compressive axial force (perhaps due to greater BMI) applied to a knee that is already at an increased risk because of its geometry, such as a steep lateral posterior tibial slope, could further increase the probability of ACL injury...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28245264/longitudinal-analysis-of-antibody-responses-in-symptomatic-malaria-cases-do-not-mirror-parasite-transmission-in-peri-urban-area-of-cote-d-ivoire-between-2010-and-2013
#13
David Koffi, Marie-Louise Varela, Cheikh Loucoubar, Sylvain Beourou, Inès Vigan-Womas, Aissatou Touré, Joseph Allico Djaman, André Offianan Touré, Ronald Perraut
BACKGROUND: In the agenda towards malaria eradication, assessment of both malaria exposure and efficacy of anti-vectorial and therapeutic strategies is a key component of management and the follow-up of field interventions. The simultaneous use of several antigens (Ags) as serological markers has the potential for accurate evaluation of malaria exposure. Here we aimed to measure the longitudinal evolution of the background levels of immunity in an urban setting in confirmed clinical cases of malaria...
2017: PloS One
https://www.readbyqxmd.com/read/28245257/cross-linked-%C3%AE-cyclodextrin-and-carboxymethyl-cellulose-hydrogels-for-controlled-drug-delivery-of-acyclovir
#14
Nadia Shamshad Malik, Mahmood Ahmad, Muhammad Usman Minhas
To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N' N'-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network...
2017: PloS One
https://www.readbyqxmd.com/read/28244431/compact-ir-synchrotron-beamline-design
#15
Thierry Moreno
Third-generation storage rings are massively evolving due to the very compact nature of the multi-bend achromat (MBA) lattice which allows amazing decreases of the horizontal electron beam emittance, but leaves very little place for infrared (IR) extraction mirrors to be placed, thus prohibiting traditional IR beamlines. In order to circumvent this apparent restriction, an optimized optical layout directly integrated inside a SOLEIL synchrotron dipole chamber that delivers intense and almost aberration-free beams in the near- to mid-IR domain (1-30 µm) is proposed and analyzed, and which can be integrated into space-restricted MBA rings...
March 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28240860/development-of-bioactive-pegylated-nanostructured-platforms-for-sequential-delivery-of-doxorubicin-and-imatinib-to-overcome-drug-resistance-in-metastatic-tumors
#16
Biki Gupta, Thiruganesh Ramasamy, Bijay Kumar Poudel, Shiva Pathak, Shobha Regmi, Ju Yeon Choi, Youlim Son, Raj Kumar Thapa, Jee-Heon Jeong, Jae Ryong Kim, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib (IMT) intended to effectively inhibit metastatic tumors. The DOX and IMT coloaded nanostructured system (DOX/IMT-N) is characterized by an excellent encapsulation potential for both drugs and shows sequential and sustained drug release in vitro. DOX/IMT-N significantly inhibited the in vitro proliferation of MDA-MB-231 and SK-MEL-28 cells...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28219762/evaluation-of-the-performances-of-twelve-rapid-diagnostic-tests-for-diagnosis-of-hiv-infection-in-yaounde-cameroon
#17
Richard Njouom, Laure Ngono, Desirée Denise Mekinda-Gometi, Cyprien Kengne Ndé, Serge Alain Sadeuh-Mba, Marie-Astrid Vernet, Patrice Tchendjou, Guy Vernet
According to the WHO/UNAIDS recommendations, an acceptable HIV rapid diagnostic tests (RDTs) has to perform a sensitivity≥99% and a specificity≥98%. Given the constant release of new RDTs for HIV testing in the market and the high HIV genetic diversity in Cameroon, it is interesting to monitor their performances in that setting. A total of 240 HIV positive (including 219 HIV-1 M, 15 HIV-1 O, 1 HIV-1 N, 1 HIV-1 M/O recombinant and 4 HIV-2) and 240 HIV negative plasma samples were used to evaluate twelve routinely used RDTs in Cameroon...
May 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28214223/evaluation-of-a-field-test-for-antibodies-against-chlamydia-trachomatis-during-trachoma-surveillance-in-nepal
#18
Michelle J Sun, Andrea I Zambrano, Laura Dize, Beatriz Munoz, Sarah Gwyn, Sailesh Mishra, Diana L Martin, Shekhar Sharma, Sheila K West
PURPOSE: Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from 1509 children and tested onsite for anti-Pgp3 antibodies by LFA. The LFA was read at 30min as negative, positive, or invalid. Tests results were also rated as difficult to read ("equivocal")...
January 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28213329/thioaromatic-dna-monolayers-for-target-amplification-free-electrochemical-sensing-of-environmental-pathogenic-bacteria
#19
Rebeca Miranda-Castro, Raquel Sánchez-Salcedo, Beatriz Suárez-Álvarez, Noemí de-Los-Santos-Álvarez, Arturo J Miranda-Ordieres, María Jesús Lobo-Castañón
Genosensing technology has mostly based on mixed self-assembled monolayers (SAMs) of thiol-modified oligonucleotides and alkanethiols on gold surfaces. However, the typical backfilling approach, which incorporates the alkanethiol in a second step, gives rise to a heterogeneous distribution of oligonucleotide probes on the surface, negatively affecting to both hybridization efficiency and surface stability. Despite aromatic thiols present a remarkably different behavior from alkanethiols, with higher rigidity and stronger intermolecular interactions, they have been scarcely explored for the fabrication of DNA sensing platforms...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28205415/microfluidic-screening-reveals-heparan-sulfate-enhances-human-mesenchymal-stem-cell-growth-by-modulating-fibroblast-growth-factor-2-transport
#20
Drew M Titmarsh, Clarissa L L Tan, Nick R Glass, Victor Nurcombe, Justin J Cooper-White, Simon M Cool
Cost-effective expansion of human mesenchymal stem/stromal cells (hMSCs) remains a key challenge for their widespread clinical deployment. Fibroblast growth factor-2 (FGF-2) is a key hMSC mitogen often supplemented to increase hMSC growth rates. However, hMSCs also produce endogenous FGF-2, which critically interacts with cell surface heparan sulfate (HS). We assessed the interplay of FGF-2 with a heparan sulfate variant (HS8) engineered to bind FGF-2 and potentiate its activity. Bone marrow-derived hMSCs were screened in perfused microbioreactor arrays (MBAs), showing that HS8 (50 μg/ml) increased hMSC proliferation and cell number after 3 days, with an effect equivalent to FGF-2 (50 ng/ml)...
February 16, 2017: Stem Cells Translational Medicine
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