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https://www.readbyqxmd.com/read/28219762/evaluation-of-the-performances-of-twelve-rapid-diagnostic-tests-for-diagnosis-of-hiv-infection-in-yaounde-cameroon
#1
Richard Njouom, Laure Ngono, Desirée Denise Mekinda-Gometi, Cyprien Kengne Ndé, Serge Alain Sadeuh-Mba, Marie-Astrid Vernet, Patrice Tchendjou, Guy Vernet
According to the WHO/UNAIDS recommendations, an acceptable HIV rapid diagnostic tests (RDTs) has to perform a sensitivity ≥ 99% and a specificity ≥ 98%. Given the constant release of new RDTs for HIV testing in the market and the high HIV genetic diversity in Cameroon, it is interesting to monitor their performances in that setting. A total of 240 HIV positive (including 219 HIV-1M, 15 HIV-1 O, 1 HIV-1N, 1 HIV-1M/O recombinant and 4 HIV-2) and 240 HIV negative plasma samples were used to evaluate twelve routinely used RDTs in Cameroon...
February 17, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28214223/evaluation-of-a-field-test-for-antibodies-against-chlamydia-trachomatis-during-trachoma-surveillance-in-nepal
#2
Michelle J Sun, Andrea I Zambrano, Laura Dize, Beatriz Munoz, Sarah Gwyn, Sailesh Mishra, Diana L Martin, Shekhar Sharma, Sheila K West
PURPOSE: Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from 1509 children and tested onsite for anti-Pgp3 antibodies by LFA. The LFA was read at 30min as negative, positive, or invalid. Tests results were also rated as difficult to read ("equivocal")...
January 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28213329/thioaromatic-dna-monolayers-for-target-amplification-free-electrochemical-sensing-of-environmental-pathogenic-bacteria
#3
Rebeca Miranda-Castro, Raquel Sánchez-Salcedo, Beatriz Suárez-Álvarez, Noemí de-Los-Santos-Álvarez, Arturo J Miranda-Ordieres, María Jesús Lobo-Castañón
Genosensing technology has mostly based on mixed self-assembled monolayers (SAMs) of thiol-modified oligonucleotides and alkanethiols on gold surfaces. However, the typical backfilling approach, which incorporates the alkanethiol in a second step, gives rise to a heterogeneous distribution of oligonucleotide probes on the surface, negatively affecting to both hybridization efficiency and surface stability. Despite aromatic thiols present a remarkably different behavior from alkanethiols, with higher rigidity and stronger intermolecular interactions, they have been scarcely explored for the fabrication of DNA sensing platforms...
February 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28205415/microfluidic-screening-reveals-heparan-sulfate-enhances-human-mesenchymal-stem-cell-growth-by-modulating-fibroblast-growth-factor-2-transport
#4
Drew M Titmarsh, Clarissa L L Tan, Nick R Glass, Victor Nurcombe, Justin J Cooper-White, Simon M Cool
Cost-effective expansion of human mesenchymal stem/stromal cells (hMSCs) remains a key challenge for their widespread clinical deployment. Fibroblast growth factor-2 (FGF-2) is a key hMSC mitogen often supplemented to increase hMSC growth rates. However, hMSCs also produce endogenous FGF-2, which critically interacts with cell surface heparan sulfate (HS). We assessed the interplay of FGF-2 with a heparan sulfate variant (HS8) engineered to bind FGF-2 and potentiate its activity. Bone marrow-derived hMSCs were screened in perfused microbioreactor arrays (MBAs), showing that HS8 (50 μg/ml) increased hMSC proliferation and cell number after 3 days, with an effect equivalent to FGF-2 (50 ng/ml)...
February 16, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28190508/navigating-the-clinical-trial-pathway-conception-design-execution-and-results-dissemination
#5
John S Sampalis, Joanne Watson, Stella Boukas, Marianna Boukas, Natalie Harvey, Sanjay Machado, Michel Bordeleau, Emmanouil Rampakakis
Dr Sampalis is founder, Chief Executive Officer, and Chief Scientific Officer of JSS Medical Research Inc, founded in 1997. He is a tenured professor of Surgery and Epidemiology & Biostatistics of McGill University, the University of Montreal and University of Laval. Recognized as a leading clinical epidemiologist and one of the top trauma researchers in Canada, he possesses extensive expertise in health services research, clinical trials, and offers services as a Research and Epidemiological Consultant for numerous pharmaceutical companies, hospitals and government organizations and agencies...
March 2017: Surgery
https://www.readbyqxmd.com/read/28177181/radial-endobronchial-ultrasound-for-the-diagnosis-of-peripheral-pulmonary-lesions-a-systematic-review-and-meta-analysis
#6
REVIEW
Muhammad S Ali, William Trick, Benjamin I Mba, Divyanshu Mohananey, Jaskaran Sethi, Ali I Musani
Tissue diagnosis of peripheral pulmonary lesions (PPLs) can be challenging. In the past, flexible bronchoscopy was commonly performed for this purpose but its diagnostic yield is suboptimal. This has led to the development of new bronchoscopic modalities such as radial endobronchial ultrasound (R-EBUS), electromagnetic navigation bronchoscopy (ENB) and virtual bronchoscopy (VB). We performed this meta-analysis using data from previously published R-EBUS studies, to determine its diagnostic yield and other performance characteristics...
February 8, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28153276/ultrasensitive-sers-aptasensor-for-the-detection-of-oxytetracycline-based-on-a-gold-enhanced-nano-assembly
#7
Fanwei Meng, Xiaoyuan Ma, Nuo Duan, Shijia Wu, Yu Xia, Zhouping Wang, Baocai Xu
This paper investigated a new detection method of oxytetracycline (OTC) in aquatic products with ultrasensitive detection limit. The method was constructed on the basis of raman hot spot between gold nanoparticles (AuNPs) (13nm and 80nm diameter respectively) linked by an DNA sequence. The DNA sequence combined with the OTC aptamer including its complementary sequence as well as a stem-loop structure. The raman signal molecule (4-MBA) was modified at the surface of 13nm AuNPs. After the exposure of OTC, the aptamer sequence was preferentially combined with OTC and partially dehybridized with its complementary sequence which led the 13nm AuNPs to get more closer to the 80nm AuNPs...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28144566/surface-enhanced-raman-scattering-of-self-assembled-thiol-monolayers-and-supported-lipid-membranes-on-thin-anodic-porous-alumina
#8
Marco Salerno, Amirreza Shayganpour, Barbara Salis, Silvia Dante
Thin anodic porous alumina (tAPA) was fabricated from a 500 nm thick aluminum (Al) layer coated on silicon wafers, through single-step anodization performed in a Teflon electrochemical cell in 0.4 M aqueous phosphoric acid at 110 V. Post-fabrication etching in the same acid allowed obtaining tAPA surfaces with ≈160 nm pore diameter and ≈80 nm corresponding wall thickness to be prepared. The tAPA surfaces were made SERS-active by coating with a thin (≈25 nm) gold (Au) layer. The as obtained tAPA-Au substrates were incubated first with different thiols, namely mercaptobenzoic acid (MbA) and aminothiol (AT), and then with phospholipid vesicles of different composition to form a supported lipid bilayer (SLB)...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28131054/impedimetric-nanostructured-genosensor-for-detection-of-schistosomiasis-in-cerebrospinal-fluid-and-serum-samples
#9
Giselle S Santos, Cesar A S Andrade, Igor S Bruscky, Leandro B Wanderley, Fabio L Melo, Maria D L Oliveira
Schistosomiasis is a neglected disease closely related to the low levels of social development and a serious public health problem. In this work, we performed an electrochemical detection of Schistosoma mansoni DNA with a self-assembled monolayer of mercaptobenzoic acid (MBA) immobilizing nanostructures composed of gold nanoparticles (AuNPs) and magnetite nanoparticles (Fe3O4_NPs). Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were used to monitor the hybridization process. MBA-Fe3O4_NPs-AuNPs-DNAprobe system reveals an effective electrochemical response indicating the surface modification...
January 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28107905/a-multi-walled-carbon-nanotubes-based-molecularly-imprinted-polymers-electrochemical-sensor-for-the-sensitive-determination-of-hiv-p24
#10
Ya Ma, Xiao-Lei Shen, Qiang Zeng, Hai-Shui Wang, Li-Shi Wang
To develop a rapid, simple and sensitive method for the determination of human immunodeficiency virus p24 (HIV-p24), a novel molecularly imprinted polymers (MIPs) electrochemical sensor was constructed on the surface of a multi-walled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE) by surface polymerization using acrylamide (AAM) as functional monomer, N,N'-methylenebisacrylamide (MBA) as cross-linking agent and ammonium persulphate (APS) as initiator. Each modification step was carefully examined by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and scanning electron microscope (SEM)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28092049/rosette-assay-highly-customizable-dot-blot-for-sh2-domain-screening
#11
Khong Y Ng, Kazuya Machida
With a growing number of high-throughput studies, structural analyses, and availability of protein-protein interaction databases, it is now possible to apply web-based prediction tools to SH2 domain-interactions. However, in silico prediction is not always reliable and requires experimental validation. Rosette assay is a dot blot-based reverse-phase assay developed for the assessment of binding between SH2 domains and their ligands. It is conveniently customizable, allowing for low- to high-throughput analysis of interactions between various numbers of SH2 domains and their ligands, e...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28088076/in%C3%A2-vivo-visualization-of-endogenous-mir-21-using-hyaluronic-acid-coated-graphene-oxide-for-targeted-cancer-therapy
#12
Do Won Hwang, Han Young Kim, Fangyuan Li, Ji Yong Park, Dohyun Kim, Jae Hyung Park, Hwa Seung Han, Jung Woo Byun, Yun-Sang Lee, Jae Min Jeong, Kookheon Char, Dong Soo Lee
Oncogene-targeted nucleic acid therapy has been spotlighted as a new paradigm for cancer therapeutics. However, in vivo delivery issues and uncertainty of therapeutic antisense drug reactions remain critical hurdles for a successful targeted cancer therapy. In this study, we developed a fluorescence-switchable theranostic nanoplatform using hyaluronic acid (HA)-conjugated graphene oxide (GO), which is capable of both sensing oncogenic miR-21 and inhibiting its tumorigenicity simultaneously. Cy3-labeled antisense miR-21 peptide nucleic acid (PNA) probes loaded onto HA-GO (HGP21) specifically targeted CD44-positive MBA-MB231 cells and showed fluorescence recovery by interacting with endogenous miR-21 in the cytoplasm of the MBA-MB231 cells...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28081000/on-the-development-of-a-vipar-nd-radiotherapy-3d-polymer-gel-dosimeter
#13
Marek Kozicki, Malwina Jaszczak, Piotr Maras, Mariusz Dudek, Marian Cłapa
This work presents an improvement of the VIPAR(nd) ('nd' stands for 'normoxic, double', or VIP) polymer gel dosimeter. The gel composition was altered by increasing the concentration of the monomeric components, N-vinylpyrrolidone (NVP) and N,N'-methylenebisacrylamide (MBA), in co-solvent solutions. The optimal composition (VIPAR(CT), where 'CT' stands for computed tomography, or VIC) comprised: 17% NVP, 8% MBA, 12% t-BuOH, 7.5% gelatine, 0.007% ascorbic acid, 0.0008% CuSO4  ×  5H2O and 0.02% hydroquinone...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28067985/the-role-of-a-double-molecular-anchor-on-the-mobility-and-self-assembly-of-thiols-on-au-111-the-case-of-mercaptobenzoic-acid
#14
Miriam Candelaria Rodríguez González, Pilar Carro, Evangelina Pensa, Carolina Vericat, Roberto Salvarezza, Alberto Hernández Creus
The dynamics of the self-assembly process of thiol molecules on Au(111) is affected by the interplay between molecule-substrate and molecule-molecule interactions. Therefore, it is interesting to explore the effect of a second anchor to the gold surface, in addition to the S atom, on both the order and the feasibility of phase transitions in self-assembled monolayers. To assess the role of an additional O anchor, we have compared the adsorption of two mercaptobenzoic acid isomers, 2-mercaptobenzoic acid (2-MBA) and 4-mercaptobenzoic acid (4-MBA), on Au(111)...
January 9, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28064507/lantana-camara-linn-root-extract-mediated-gold-nanoparticles-and-their-in-vitro-antioxidant-and-cytotoxic-potentials
#15
Rajendiran Ramkumar, Govindasamy Balasubramani, Ramalingam Karthik Raja, Manickam Raja, Raji Govindan, Easwaradas Kreedapathy Girija, Pachiappan Perumal
The Lantana camara Linn root extract derived gold nanoparticles (Au NPs) were characterized by Ultraviolet-Visible spectroscopy, X-ray diffraction, fourier transform-infrared, high resolution transmission electron microscopy, selected area electron diffraction pattern and energy dispersive X-ray analyses. In DPPH assay, the inhibitory concentration (IC50) of Au NPs and gallic acid was 24.17 and 5.39 μg/ml, whereas, for cytotoxicity assay, the IC50 of Au NPs was 17.72 and 32.98 μg/ml on MBA-MB-231 and Vero cells, respectively...
January 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28033210/2016-visionary-leader-bob-dent
#16
Brandon Kit Bredimus
The following manuscript is the winning Richard Hader Visionary Leader 2016 entry submitted to Nursing Management in recognition of Dr. Bob Dent, DNP, MBA, RN, NEA-BC, CENP, FACHE, senior vice president, chief operating officer, and CNO for Midland Memorial Hospital in Midland, Tex. Dr. Dent was formally recognized for his achievements before the Keynote Address at Congress2016, November 8, in Las Vegas, Nev. There, he received the award, sponsored by Hackensack Meridian Health.
January 2017: Nursing Management
https://www.readbyqxmd.com/read/28032773/the-dark-side-of-going-abroad-how-broad-foreign-experiences-increase-immoral-behavior
#17
Jackson G Lu, Jordi Quoidbach, Francesca Gino, Alek Chakroff, William W Maddux, Adam D Galinsky
Because of the unprecedented pace of globalization, foreign experiences are increasingly common and valued. Past research has focused on the benefits of foreign experiences, including enhanced creativity and reduced intergroup bias. In contrast, the present work uncovers a potential dark side of foreign experiences: increased immoral behavior. We propose that broad foreign experiences (i.e., experiences in multiple foreign countries) foster not only cognitive flexibility but also moral flexibility. Using multiple methods (longitudinal, correlational, and experimental), 8 studies (N > 2,200) establish that broad foreign experiences can lead to immoral behavior by increasing moral relativism-the belief that morality is relative rather than absolute...
January 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28003019/agonists-and-knockdown-of-estrogen-receptor-%C3%AE-differentially-affect-invasion-of-triple-negative-breast-cancer-cells-in-vitro
#18
Susanne Schüler-Toprak, Julia Häring, Elisabeth C Inwald, Christoph Moehle, Olaf Ortmann, Oliver Treeck
BACKGROUND: Estrogen receptor β (ERβ) is expressed in the majority of invasive breast cancer cases, irrespective of their subtype, including triple-negative breast cancer (TNBC). Thus, ERβ might be a potential target for therapy of this challenging cancer type. In this in vitro study, we examined the role of ERβ in invasion of two triple-negative breast cancer cell lines. METHODS: MDA-MB-231 and HS578T breast cancer cells were treated with the specific ERβ agonists ERB-041, WAY200070, Liquiritigenin and 3β-Adiol...
December 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27998658/authorship-trends-in-30-years-of-the-journal-of-arthroplasty
#19
Jason D Lehman, William W Schairer, Alex Gu, Jason L Blevins, Peter K Sculco
BACKGROUND: While various studies have investigated trends in characteristics of authors in other medical literature, no study has examined these characteristics in the field of arthroplasty. METHODS: A database was created of all articles published in The Journal of Arthroplasty in 1986, 1990, 1995, 2000, 2005, 2010, and 2015. Degree(s) of authors, number of authors, number of references, and region of institution were recorded. RESULTS: A total of 1343 original articles were assessed over the study period...
November 27, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27990519/roles-of-the-methyl-and-methylene-groups-of-mercapto-acids-in-the-photoluminescence-efficiency-and-carrier-trapping-dynamics-of-cdte-qds
#20
M Chandra Sekhar, Apurba De, Sk Saddam Hossain, Anunay Samanta
Surface protection using an appropriate ligand is essential for controlling the size, stability and luminescence properties of the quantum dots (QDs). Though 3-mercaptopropanoic acid (3-MPA) is regarded as the most suitable protecting ligand among the mercapto acids for water soluble CdTe QDs, one receives a different picture from recent studies, which report a much higher luminescence efficiency of 3-mercaptobutyric acid (3-MBA) capped QDs compared with those capped by 3-MPA and attribute the observation to the influence of the side methyl group of mercapto acids...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
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