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Choline peak in breast mri

Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
Jane Wang, Tiffany Ting-Fang Shih, Ruoh-Fang Yen
PURPOSE: The aim of this study was to investigate whether integrated PET/MR system can predict the treatment response to neoadjuvant chemotherapy (NAC) early in the course of breast cancer treatment. METHODS: Fourteen women with newly diagnosed invasive breast cancer (median age, 54.5 years) were recruited. Each participant underwent 2 PET/MR studies. Study 1 was pre-NAC; study 2 was early in NAC treatment (after the first or second cycle). PET parameters included SUVmax and total lesion glycolysis (TLG)...
July 2017: Clinical Nuclear Medicine
Stefania Montemezzi, Carlo Cavedon, Lucia Camera, Gabriele Meliadò, Francesca Caumo, Ilaria Baglio, Francesco Sardanelli
OBJECTIVES: To test 3T proton magnetic resonance spectroscopy ((1)H-MRS) for breast mass lesions. METHODS: Patients with BI-RADS 4-5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm(3); TR/TE = 3000/135 ms) was performed. Spectra were considered reliable if the full width at half maximum (FWHM) of the water peak was ≤45 Hz...
March 2017: La Radiologia Medica
Carlo Cavedon, Gabriele Meliadò, Linda Rossi, Lucia Camera, Ilaria Baglio, Francesca Caumo, Stefania Montemezzi
INTRODUCTION: The aim of this work was to assess the role of 3T-MR spectroscopy (MRS) in the multi-parametric MRI evaluation of breast lesions, using a pattern-recognition based classification method. METHODS: 291 patients (301 lesions, median 2.3cm(3)) were enrolled in the study (age 18-85y, mean 54.2y). T1-TSE (TR/TE=400/10ms) and T2-STIR imaging (TR/TE=5000/60ms), dynamic-contrast-enhanced MRI (DCE-MRI), apparent diffusion coefficient (ADC) (b=0-800s/mm(2)), and single-voxel MRS (10×10×10mm(3), PRESS, TR/TE=3000ms/135ms) were performed by means of a 3T scanner...
December 2016: Physica Medica: PM
Manju Bala Popli, Pranav Gupta, Devraj Arse, Pawan Kumar, Prabhjot Kaur
OBJECTIVE: The purpose of this research work was to evaluate complex cystic breast lesions by advanced MRI techniques and correlating imaging with histologic findings. METHODS AND MATERIALS: In a cross-sectional design from September 2013 to August 2015, 50 patients having sonographically detected complex cystic lesions of the breast were included in the study. Morphological characteristics were assessed. Dynamic contrast-enhanced MRI along with diffusion-weighted imaging and MR spectroscopy were used to further classify lesions into benign and malignant categories...
2016: Breast Cancer: Basic and Clinical Research
Erkin Aribal, Ruslan Asadov, Abdullah Ramazan, Mustafa Ümit Ugurlu, Handan Kaya
OBJECTIVES: To evaluate the diagnostic accuracy of dynamic contrast enhanced breast MRI (DCE-MRI) combined with diffusion weighted imaging (DWI) and 1H single-voxel magnetic resonance spectroscopy (1HMRS) in differentiating malignant from benign breast lesions. METHODS: One hundred twenty-nine patients with 138 lesions were included in the study. Multiparametric MRI of the breast was performed with a 3T unit. A DWI is followed by DCE-MRI and 1HMRS. All lesions were biopsied within one week after MRI...
May 2016: European Journal of Radiology
Dževad Belkić, Karen Belkić
Magnetic resonance (MR)-based modalities aid breast cancer detection without exposure to ionizing radiation. Magnetic resonance imaging is very sensitive but costly and insufficiently specific. Molecular imaging through magnetic resonance spectroscopy (MRS) can provide information about key metabolites. Here, the measured/encoded time signals cannot be interpreted directly, necessitating mathematics for mapping to the more manageable frequency domain. Conventional applications of MRS are hampered by data analysis via the fast Fourier transform (FFT) and postprocessing by fitting techniques...
June 2015: Technology in Cancer Research & Treatment
Rani G Sah, Khushbu Agarwal, Uma Sharma, Rajinder Parshad, Vurthaluru Seenu, Naranamangalam R Jagannathan
PURPOSE: To investigate the potential of diffusion weighted imaging (DWI) and in vivo proton MR spectroscopy (MRS) in the differentiation of breast tissue of healthy lactating women volunteers and breast cancer patients. MATERIALS AND METHODS: DWI and MRS were carried out at 1.5 Tesla on 12 breast cancer patients and 12 normal lactating women volunteers. Apparent diffusion coefficient (ADC) and total choline (tCho) concentration were determined. RESULTS: tCho was observed in all breast cancer patients and in 10/12 lactating women...
January 2015: Journal of Magnetic Resonance Imaging: JMRI
Ioannis Tsougos, Patricia Svolos, Evanthia Kousi, Evangelos Athanassiou, Kiriaki Theodorou, Dimitrios Arvanitis, Ioannis Fezoulidis, Katerina Vassiou
BACKGROUND: Conventional breast magnetic resonance imaging (MRI), including dynamic contrast-enhanced MR mammography (DCE-MRM), may lead to ambiguous diagnosis and unnecessary biopsies. PURPOSE: To investigate the contribution of proton MR spectroscopy (1H-MRS) combined with diffusion tensor imaging (DTI) metrics in the discrimination between benign and malignant breast lesions. MATERIAL AND METHODS: Fifty-one women with known breast abnormalities from conventional imaging were examined on a 3T MR scanner...
February 2014: Acta Radiologica
(no author information available yet)
AIM: To enhance the efficiency of diagnosis of breast tumors by comprehensive magnetic resonance imaging (MRI) involving dynamic contrast-enhanced magnetic resonance mammography (MRM) and magnetic resonance spectroscopy (MRS). SUBJECTS AND METHODS: Eighty-seven women aged 32 to 75 years with breast neoplasms were examined. MRM was performed on a Philips Achieva 3.0T TX scanner. The MRI protocol consisted of axial fat-suppressed T1- and T2-weighted spin-echo images and 8 postcontrast dynamic series...
2013: Terapevticheskiĭ Arkhiv
S Suppiah, K Rahmat, M N Mohd-Shah, C A Azlan, L K Tan, Y F A Aziz, A Vijayananthan, A L Wui, C H Yip
AIM: To investigate the diagnostic accuracy of single-voxel proton magnetic resonance spectroscopy (SV (1)H MRS) by quantifying total choline-containing compounds (tCho) in differentiating malignant from benign lesions, and subsequently, to analyse the relationship of tCho levels in malignant breast lesions with their histopathological subtypes. MATERIALS AND METHODS: A prospective study of SV 1H MRS was performed following dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in 61 women using a 3 T MR system...
September 2013: Clinical Radiology
Katerina Vassiou, Ioannis Tsougos, Evanthia Kousi, Marianna Vlychou, Evaggelos Athanasiou, Kiriaki Theodorou, Dimitrios L Arvanitis, Ioannis V Fezoulidis
BACKGROUND: Assessment of breast lesions with magnetic resonance imaging (MRI) provides a means for lesion detection and diagnosis. Proton (hydrogen-1) magnetic resonance spectroscopy ((1)H-MRS) has been proposed as a useful diagnostic technique in providing metabolic information of suspicious breast lesions. PURPOSE: To determine the clinical significance of in-vivo single voxel (1)H-MRS at 3T in the assessment of benign and malignant breast lesions in combination with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)...
May 2013: Acta Radiologica
I Thomassin-Naggara, I Trop, L Lalonde, J David, L Péloquin, J Chopier
The standard breast MRI protocol includes T2 sequences (anatomy and signal analysis), T1 gradient-echo sequences which can detect markers placed after biopsy, and injected dynamic 3D sequences for performing volume and multiplanar reconstructions, which are particularly useful for locating lesions well. Good patient positioning is essential and is obtained by using foam wedges for small breasts, ensuring there are no folds, and the correct position of the nipples. These aspects limit movement artefacts which alter subtraction sequences, so that it must always be possible for reading these sequences to be assisted by comparing them with the native sequences...
November 2012: Diagnostic and Interventional Imaging
E Kousi, I Tsougos, K Vasiou, K Theodorou, A Poultsidi, I Fezoulidis, C Kappas
PURPOSE: To determine whether in vivo proton magnetic resonance spectroscopy at 3T can provide accurate breast lesion characterization, and to determine the effect of gadolinium on the resonance of tCho. METHODS: Twenty-four positive-mammogram patients were examined on a 3T MR scanner. 1H-MRS was performed before and after gadolinium administration. tCho peak was qualitatively evaluated before and after contrast injection. RESULTS: Fourteen out of 27 lesions proved to be malignant after histopathological diagnosis...
2012: TheScientificWorldJournal
Hee Jung Shin, Hyeon-Man Baek, Joo Hee Cha, Hak Hee Kim
OBJECTIVE: The purpose of this article is to determine whether the peak integral and signal-to-noise ratio (SNR) of total choline-containing compounds obtained by MR spectroscopy (MRS) correlate with histologic biomarkers currently used for predicting prognosis in patients with breast cancer. MATERIALS AND METHODS: Single-voxel proton MRS using a 1.5-T scanner was performed in 184 patients (mean age, 48 years; range, 28-72 years) with breast cancer. We obtained absolute total choline-containing compound peak integral, total choline-containing compound peak integral normalized for the volume of interest, and SNR after MRI...
May 2012: AJR. American Journal of Roentgenology
Hisashi Kawai, Shinji Naganawa, Hiroko Satake, Satoko Ishigaki, Yasuo Sakurai, Minako Mori, Katsuya Maruyama
PURPOSE: To assess the effects of gadolinium-based contrast agent (GBCA) on (1) H-magnetic resonance spectroscopy (MRS) of the breast at 3.0-T. MATERIALS AND METHODS: Patients (n = 98) with breast cancer (98 lesions) underwent MRS (point-resolved spectroscopy sequence [PRESS]; TR/TE, 2000/100 msec; voxel size, 15 × 15 × 15 mm) before the administration of GBCA. In 52 of those patients, MRS was also performed after the administration of GBCA. The voxel-of-interest (VOI) was placed by referring to the noncontrast-enhanced MRI (diffusion-weighted images combined with fat-suppressed T2-weighted images)...
March 2012: Journal of Magnetic Resonance Imaging: JMRI
Michael A Jacobs, Vered Stearns, Antonio C Wolff, Katarzyna Macura, Pedram Argani, Nagi Khouri, Theodore Tsangaris, Peter B Barker, Nancy E Davidson, Zaver M Bhujwalla, David A Bluemke, Ronald Ouwerkerk
RATIONALE AND OBJECTIVES: The aim of this prospective study was to investigate using multiparametric and multinuclear magnetic resonance imaging during preoperative systemic therapy for locally advanced breast cancer. MATERIALS AND METHODS: Women with operable stage 2 or 3 breast cancer who received preoperative systemic therapy were studied using dynamic contrast-enhanced magnetic resonance imaging, magnetic resonance spectroscopy, and ²³Na magnetic resonance...
December 2010: Academic Radiology
Jiani Hu, Wenzheng Feng, Jia Hua, Quan Jiang, Yang Xuan, Tao Li, E Mark Haacke
PURPOSE: The technical challenges that have prevented routine proton magnetic resonance spectroscopic imaging (1H MRSI) examinations of the breast include insufficient spatial resolution, increased difficulties in shimming compared to the brain, and strong lipid contamination at short echo time (TE) at 1.5 T. The authors investigated the feasibility of high spatial resolution 1H MRSI of human breast cancer in a clinical setting at 3 T. METHODS: Ten patient studies (eight cancers and two benign lesions) were performed in a 3 T whole-body clinical imager using a pulse sequence consisting of optional outer volume presaturation, optional CHESS pulse for lipid suppression, CHESS pulse for water suppression, and standard 2D/3D PRESS pulse sequence with an elliptical weighted k-space sampling scheme...
November 2009: Medical Physics
Mitsuhiro Tozaki, Eisuke Fukuma
OBJECTIVE: The objective of our study was to determine whether proton ((1)H) MR spectroscopy (MRS) and diffusion-weighted imaging might be useful tools for characterizing breast lesions before biopsy. MATERIALS AND METHODS: Single-voxel (1)H MRS and diffusion-weighted imaging were performed in 171 suspicious or highly suspicious lesions. Using the residual water signal as a reference (4.7 ppm), a choline peak at 3.22-3.23 ppm was defined as malignant. If a high-signal-intensity lesion was detected in high-b-value (b = 1,500 s/mm(2)) images, that lesion was defined as positive for malignancy...
September 2009: AJR. American Journal of Roentgenology
Robert E Lenkinski, Xiaoen Wang, Mostafa Elian, S Nahum Goldberg
It has been shown that magnetic resonance spectroscopy (MRS) can improve the specificity of the MR examination by the spectroscopic detection of choline (Cho). Commonly, the lesion is first visualized on postcontrast studies, and the MRS voxel is prescribed accordingly. The implicit assumption made in this approach is that the presence of gadolinium-based contrast agents will have a negligible effect on the MR spectra obtained from the lesion. In this work, we examined this assumption by determining the effects of six gadolinium-based contrast agents: Magnevist, Multihance, Omniscan, Optimark, ProHance, and Dotarem, on the Cho peak in phantoms and in a rat model for breast cancer...
June 2009: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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