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https://www.readbyqxmd.com/read/29667028/a-review-of-commercial-and-medical-grade-physiological-monitoring-devices-for-biofeedback-assisted-quality-of-life-improvement-studies
#1
Pedro Nogueira, Joana Urbano, Luís Paulo Reis, Henrique Lopes Cardoso, Daniel Castro Silva, Ana Paula Rocha, Joaquim Gonçalves, Brígida Mónica Faria
With the rise in wearable technology and "health culture", we are seeing an increasing interest and affordances in studying how to not only prolong life expectancy but also in how to improve individuals' quality of life. On the one hand, this attempts to give meaning to the increasing life expectancy, as living above a certain threshold of pain and lack of autonomy or mobility is both degrading and unfair. On the other hand, it lowers the cost of continuous care, as individuals with high quality of life indexes tend to have lower hospital readmissions or secondary complications, not to mention higher physical and mental health...
April 17, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29665635/a-mechanism-study-on-toxicity-of-graphene-oxide-to-daphnia-magna-direct-link-between-bioaccumulation-and-oxidative-stress
#2
Xiaohui Lv, Yao Yang, Yi Tao, Yuelu Jiang, Baiyang Chen, Xiaoshan Zhu, Zhonghua Cai, Bing Li
Graphene oxide (GO) possesses versatile applicability and high hydrophilicity, thus may have frequent contact with aquatic organisms. However, the ecological risks of GO in aquatic ecosystems remain largely unexplored currently. This study evaluated the comprehensive toxicological effects of GO on Daphnia magna, a key species in fresh water ecosystem. The results revealed nonsevere acute toxicities, including immobility (72 h EC50 : 44.3 mg/L) and mortality (72 h LC50 : 45.4 mg/L), of GO on D. magna. To understand the underlying mechanism of GO exposure, changes in superoxide dismutase (SOD) and lipid peroxidation (LPO) of D...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29663622/the-role-of-defensive-symbionts-in-host-parasite-coevolution
#3
Christoph Vorburger, Steve J Perlman
Understanding the coevolution of hosts and parasites is a long-standing goal of evolutionary biology. There is a well-developed theoretical framework to describe the evolution of host-parasite interactions under the assumption of direct, two-species interactions, which can result in arms race dynamics or sustained genotype fluctuations driven by negative frequency dependence (Red Queen dynamics). However, many hosts rely on symbionts for defence against parasites. Whilst the ubiquity of defensive symbionts and their potential importance for disease control are increasingly recognized, there is still a gap in our understanding of how symbionts mediate or possibly take part in host-parasite coevolution...
April 16, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29653050/dissolution-of-complex-metal-oxides-from-first-principles-and-thermodynamics-cation-removal-from-the-001-surface-of-li-ni-1-3-mn-1-3-co-1-3-o-2
#4
Joseph Bennett, Diamond Jones, Xu Huang, Robert J Hamers, Sara E Mason
The rapid increase in use of Li-ion batteries in portable electronics has created a pressing need to understand the environmental impact and long-term fate of electonic waste (e-waste) products such as heavy and/or reactive metals. The type of e-waste that we focus on here are the complex metal oxide nanomaterials that compose Li-ion battery cathodes. While in operation the complex metal oxides are in a hermetically sealed container. However, at the end of life, improper disposal can cause structural transformations such as dissolution and metal leaching, resulting in a significant exposure risk to the surrounding environment...
April 13, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29651744/prospects-of-chimeric-antigen-receptor-t-cell-therapy-in-ovarian-cancer
#5
REVIEW
Vishal Jindal, Ena Arora, Sorab Gupta, Amos Lal, Muhammad Masab, Rashmika Potdar
Despite advances in various chemotherapy regimens, current therapeutic options are limited for ovarian cancer patients. Immunotherapy provides a promising and novel treatment option for ovarian cancer. Recently, chimeric antigen receptor (CAR) T cell therapy has shown promising results in hematological tumors and current research is going on in various solid tumors like ovarian cancer. CAR T cells are genetically engineered T cells with major histocompatibility complex-independent, tumor-specific, immune-mediated cytolytic actions against cancer cells...
April 12, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29650958/phosphatase-activity-tunes-two-component-system-sensor-detection-threshold
#6
Brian P Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A Hartsough, Jeffrey J Tabor
Two-component systems (TCSs) are the largest family of multi-step signal transduction pathways in biology, and a major source of sensors for biotechnology. However, the input concentrations to which biosensors respond are often mismatched with application requirements. Here, we utilize a mathematical model to show that TCS detection thresholds increase with the phosphatase activity of the sensor histidine kinase. We experimentally validate this result in engineered Bacillus subtilis nitrate and E. coli aspartate TCS sensors by tuning their detection threshold up to two orders of magnitude...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29644784/mindy1-is-a-downstream-target-of-the-polyamines-and-promotes-embryonic-stem-cell-self-renewal
#7
Christina James, Tian Yun Zhao, Anisa Rahim, Parul Saxena, Nazreen Abdul Muthalif, Takeshi Uemura, Norihiro Tsuneyoshi, Sheena Ong, Kazuei Igarashi, Chin Yan Lim, N Ray Dunn, Leah A Vardy
Embryonic stem cells have the ability to self-renew or differentiate and these processes are under tight control. We previously reported that the polyamine regulator AMD1 is critical for embryonic stem cell self-renewal. The polyamines putrescine, spermidine and spermine are essential organic cations that play a role in a wide array of cellular processes. Here, we explore the essential role of the polyamines in the promotion of self-renewal and identify a new stem cell regulator that acts downstream of the polyamines: MINDY1...
April 12, 2018: Stem Cells
https://www.readbyqxmd.com/read/29630006/reliability-and-validity-of-the-patient-specific-functional-scale-in-community-dwelling-older-adults
#8
Ruth Ann Mathis, J David Taylor, Brian H Odom, Chad Lairamore
BACKGROUND AND PURPOSE: Clinical measurement of physical function that is both specific to the individual and generates comparable outcome data is a fundamental need in physical therapy examination. The Patient-Specific Functional Scale (PSFS) has been found to be a reliable and valid measure of physical function in patients with musculoskeletal disorders and may have applications for other patient populations. However, the reliability and the validity of the PSFS have not been evaluated in older adults...
April 6, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29628752/from-what-the-hell-is-going-on-to-the-mushy-middle-ground-to-getting-used-to-a-new-normal-young-people-s-biographical-narratives-around-navigating-parental-dementia
#9
Mel Hall, Pat Sikes
The number of young people who have a parent with dementia is rising as a result of improvements in diagnosis of young onset variants and demographic shifts. There has, however, been very little research focusing on this group. Accounts elicited as part of the Perceptions and Experiences of Young People With a Parent With Dementia described the period, usually some years, leading up to a diagnosis of a dementia and then the progress of the condition post diagnosis. These narratives were characterized by confusion, uncertainty, trauma, and distress as the young people struggled to make sense of the significant and often extreme, behavioral and attitudinal changes that were symptoms of the illness...
April 2018: Illness, Crises, and Loss
https://www.readbyqxmd.com/read/29627005/natural-history-of-benign-multiple-sclerosis-clinical-and-hla-correlates-in-a-western-australian-cohort
#10
Marzena J Fabis-Pedrini, Ian James, Alexandra Seewann, Wai Y Yau, Arnold A van de Bovenkamp, Fay R K Sanders, Wei Qiu, Jason Burton, Frank L Mastaglia, William M Carroll, Allan G Kermode
BACKGROUND: Benign multiple sclerosis (BMS) is a controversial term that has been used for MS patients with minimal disability decades after disease onset. Herein, we evaluated disease status after 20 years in a Western Australian cohort defined as BMS based on an Expanded Disability Status Scale (EDSS) score ≤ 3.0 at 10 years from onset. METHODS: MS patients with an EDSS score ≤ 3.0 at 10 years from onset and minimum of 20 years follow up were included in the study...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29626975/a-77-year-old-woman-with-acute-shortness-of-breath-and-chest-pain
#11
Ryan Hyde, Julian Chung, Jason Chertoff, Hassan Alnuaimat, Ali Ataya
A 77-year-old woman presented to the hospital with symptoms of progressive shortness of breath with associated right-sided pleuritic pain. The patient had begun noting dyspnea on exertion, limiting her ability to go on hikes over the few days prior to admission. Her medical history is significant for carcinoid tumor status postresection in 2012 without recurrence. She has no history of thromboembolism or clotting disorders, and she has no history of smoking or drug abuse. Current medications include amlodipine, celecoxib, hydrochlorothiazide, and rosuvastatin...
April 2018: Chest
https://www.readbyqxmd.com/read/29625579/is-treatment-outcome-improved-if-patients-match-themselves-to-treatment-options-study-protocol-for-a-randomized-controlled-trial
#12
Morten Ellegaard Hell, William R Miller, Bent Nielsen, Anette Søgaard Nielsen
BACKGROUND: Research on matching patients to treatment has shown that matching grounded in expert views is little better than allocating patients by chance. Furthermore, there is growing emphasis on involving patients in their own treatment as a key to health behavior change. Research on the benefit of having patients choose their treatment from among options, in contrast to being assigned to a treatment by experts, has been limited. Consequently, we designed a rigorous test of patient self-matching to determine whether it does improve retention, adherence, and outcome in alcoholism treatment...
April 6, 2018: Trials
https://www.readbyqxmd.com/read/29623326/graphene-amplified-femtosensitive-aptasensing-of-estradiol-an-endocrine-disruptor
#13
Jahangir Ahmad Rather, Emad A Khudaish, Palanisamy Kannan
We report the construction of a novel electrochemical femtomolar aptasensing APT-ERGO/GCE interface based on the covalent immobilization of 38-mer amine-functionalized (NH2-APT) 17β-estradiol (E2) DNA aptamers on a graphene amplifying platform. Graphene oxide (GO) was synthesized and characterized by using FTIR, UV-vis spectroscopy, XRD spectroscopy, and SEM technique. The strategy for the construction of the E2-aptasensing interface involves in a three-step modification process. (i) First, we carried out the electrochemical reduction of GO on the GCE electrode to form ERGO/GCE...
April 6, 2018: Analyst
https://www.readbyqxmd.com/read/29621026/fluid-status-assessment-in-hemodialysis-patients-and-the-association-with-outcome-review-of-recent-literature
#14
Marijke J E Dekker, Jeroen P Kooman
PURPOSE OF REVIEW: In this review, we will discuss the most recent literature regarding fluids status assessment in hemodialysis patients, and the associations with outcome. RECENT FINDINGS: Research toward technique-assisted assessment of fluid status in hemodialysis patients has been going on for many years. However, there is no absolute agreement between techniques, such as bioimpedance, lung ultrasound, biochemical markers or vena caval diameter, likely because they reflect different fluid compartments with potentially altered distribution in hemodialysis patients...
May 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29619320/-corynebacterium-jeikeium-endocarditis-a-case-report-and-comprehensive-review-of-an-underestimated-infection
#15
Kaveh Rezaei Bookani, Rachel Marcus, Eyad Cheikh, Monireh Parish, Usman Salahuddin
Diphtheroids are gram-positive pleomorphic bacilli in the family of Coryneform bacteria. These organisms are present as part of the human flora. Past practice habits had been to consider them as contaminants when isolated from clinical samples. Corynebacterium jeikeium is one of the most clinically important nondiphtherial Corynebacteria that can cause different forms of infections specifically in patients with underlying risk factors and co-morbidities including immunocompromised subjects. Through this article, we present a 67-year-old gentleman with extensive co-morbidities including heart failure with reduced ejection fraction and ESRD on hemodialysis through a femoral catheter who presented with chest pain and fatigue...
2018: IDCases
https://www.readbyqxmd.com/read/29616141/randomised-controlled-trial-to-compare-the-diagnostic-yield-of-positron-emission-tomography-ct-pet-ct-targeted-pleural-biopsy-versus-ct-guided-pleural-biopsy-in-suspected-pleural-malignancy-target-trial
#16
Duneesha de Fonseka, Wendy Underwood, Louise Stadon, Najib Rahman, Anthony Edey, Chris Rogers, Nick A Maskell
Introduction: Pleural malignancy, particularly malignant pleural mesothelioma (MPM) is increasing in incidence due to the long latency period from exposure to asbestos to development of the disease. MPM can be challenging to diagnose. For patients presenting without a pleural effusion, CT-guided biopsy remains the primary choice of biopsy, but the diagnostic sensitivity of this investigation is 70%-75%. Therefore, a proportion of patients will go on to require further biopsies. If the first biopsy is non-diagnostic, the chances of further non-diagnostic biopsies are high in MPM...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29604148/differential-promoter-methylation-of-dazl-gene-in-bulls-with-varying-seminal-parameters
#17
N Sarova, S Ahlawat, A Grewal, R Sharma, R Arora
In India, cross-breeding of indigenous cattle with exotic cattle such as Holstein Friesian and Jersey has been going on since last four decades to improve milk production. Although it has led to increased milk yield, the subfertility in male cross-bred progeny has remained a significant problem. Epigenetic modifications (DNA methylation, histone modifications and chromatin remodelling) are regarded as key players influencing gene expression. DAZL gene plays an important role in germline development and gametogenesis...
March 31, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29600330/measuring-the-impact-of-gastrointestinal-variables-on-the-systemic-outcome-of-two-suspensions-of-posaconazole-by-a-pbpk-model
#18
Bart Hens, Arjang Talattof, Paulo Paixão, Marival Bermejo, Yasuhiro Tsume, Raimar Löbenberg, Gordon L Amidon
For the last two decades, the application of physiologically based pharmacokinetic (PBPK) models has grown exponentially in the field of oral absorption and in a regulatory context. Although these models are widely used, their predictive power should be validated and optimized in order to rely on these models and to know exactly what is going on "under the hood". In this study, an automated sensitivity analysis (ASA) was performed for 11 gastrointestinal (GI) variables that are integrated into the PBPK software program Simcyp®...
March 29, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29599991/older-people-and-their-families-perceptions-about-their-experiences-with-interprofessional-teams
#19
Sherry Dahlke, Kim Steil, Rosalie Freund-Heritage, Marnie Colborne, Susan Labonte, Adrian Wagg
Aim: To examine older people and their families' perceptions about their experiences with interprofessional teams. Design: Naturalistic inquiry using qualitative descriptive methods to provide a comprehensive summary of older people and their families' experiences with interprofessional teams. Methods: Interviews were conducted with 22 people from 11 families. The families had experiences with teams in a variety of settings, such as community, residential care and hospital...
April 2018: Nursing Open
https://www.readbyqxmd.com/read/29599735/on-the-determinants-and-outcomes-of-passion-for-playing-pok%C3%A3-mon-go
#20
Gábor Orosz, Ágnes Zsila, Robert J Vallerand, Beáta Böthe
In 2016, Pokémon Go became the most popular smartphone game. Despite the increasing popularity of this augmented reality game, to date, no studies have investigated passion for playing Pokémon Go. On the theoretical basis of the Dualistic Model of Passion (DMP), our goal was to investigate the associations between Pokémon Go playing motives, passion, and impulsivity. A total of 621 Pokémon Go players participated in the study (54.9% female; M age = 22.6 years, SD age = 4.4). It was found that impulsivity was more strongly associated with obsessive passion (OP) than with harmonious passion (HP)...
2018: Frontiers in Psychology
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