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Abby R Rosenberg, Joanne Wolfe, Lori Wiener, Maureen Lyon, Chris Feudtner
Importance: For clinicians caring for adolescent patients living with progressive, life-threatening illness, discussions regarding prognosis, goals of care, and treatment options can be extremely challenging. While clinicians should respect and help to facilitate adolescents' emerging autonomy, they often must also work with parents' wishes to protect patients from the emotional distress of hearing bad news. Observations: We reviewed the ethical justifications for and against truth-telling, and we considered the published ethical and practice guidance, as well as the perspectives of patients, parents, and clinicians involved in these cases...
October 17, 2016: JAMA Pediatrics
Spoorthi Ravi Banavar, Prashanthi Chippagiri, Rohit Pandurangappa, Saileela Annavajjula, Premalatha Bidadi Rajashekaraiah
Background. Microscopes are omnipresent throughout the field of biological research. With microscopes one can see in detail what is going on at the cellular level in tissues. Though it is a ubiquitous tool, the limitation is that with high magnification there is a small field of view. It is often advantageous to see an entire sample at high magnification. Over the years technological advancements in optics have helped to provide solutions to this limitation of microscopes by creating the so-called dedicated "slide scanners" which can provide a "whole slide digital image...
2016: Analytical Cellular Pathology (Amsterdam)
Ryan Mills, Steve Kisely, Rosa Alati, Lane Strathearn, Jake M Najman
AIMS: To investigate whether: (1) child maltreatment is associated with lifetime cannabis use, early onset cannabis use, daily cannabis use and DSM-IV cannabis abuse in young adulthood; and (2) behaviour problems, tobacco use and alcohol use at 14 are associated with cannabis use. DESIGN: Birth cohort using linked government agency child protection data to define exposure to child maltreatment. SETTING: The Mater-University of Queensland Study of Pregnancy in Brisbane, Australia...
October 14, 2016: Addiction
Georgios Lolas, Lasse Jensen, George C Bourantas, Vasiliki Tsikourkitoudi, Konstantinos Syrigos
With the exception of a limited number of sites in the body, primary tumors infrequently lead to the demise of cancer patients. Instead, mortality and a significant degree of morbidity result from the growth of secondary tumors in distant organs. Tumor survival, growth and dissemination are associated with the formation of both new blood vessels (angiogenesis) and new lymph vessels (lymphagenesis or lymphangiogenesis). Although intensive research in tumor angiogenesis has been going on for the past four decades, experimental results in tumor lymphangiogenesis began to appear only in the last 10 years...
2016: Advances in Experimental Medicine and Biology
K P Suraj, Neethu K Kumar, E Jyothi, Kiran Vishnu Narayan, G Biju
BACKGROUND: But so far there is no proven pharmacological treatment for Idiopathic pulmonary fibrosis (IPF). As trials investigating different agents with different mechanisms of actions are going on, encouraging results have led to the licensing of the first IPF-specific drug, Pirfenidone. OBJECTIVE: To assess the proportion of IPF among interstitial lung disease patients and to assess their treatment response to Pirfenidone. MATERIAL AND METHODS: All consecutive patients attending the outpatient department from 1st January 2012 to 30th June 2012 with a proven diagnosis of Interstitial lung Disease (ILD) were included in this longitudinal cohort study...
May 2016: Journal of the Association of Physicians of India
Sanat Phatak, Latika Gupta, Amita Aggarwal
A young woman presented with panniculitis, fever and blood cytopenias, later going on to develop hemophagocytic lymphohistiocytosis. Further evaluation revealed the presence of subcutaneous panniculitis like T-cell lymphoma (SPTCL). With this case we present an approach to panniculitis, a commonly encountered skin manifestation with a wide range of differentials. We discuss the close similarity between lupus erythematous panniculitis (LEP) and lymphoma.
February 2016: Journal of the Association of Physicians of India
Falguni Parikh
Febrile patient with thrombocytopenia is commonly encountered by physicians especially during monsoon and perimonsoon period. Infections with protozoa, bacteria and viruses can cause thrombocytopenia with or without disseminated intravascular coagulation. Commonly dengue, malaria, scrub typhus and other rickettsial infections, meningococci, leptospira and certain viral infections present as fever with thrombocytopenia. Occasionally these patients can go on to develop a stormy course with multiorgan dysfunction requiring intensive care unit admission associated with high morbidity and mortality...
February 2016: Journal of the Association of Physicians of India
Ufuk Çorumlu, Cem Kopuz, Mehmet Tevfik Demir, Mennan Ece Pirzirenli
Elongation or hyperplasia of coronoid process of mandible is rare condition characterized by abnormal bone development which cause malocclusion and the limited mouth opening. In this study, in an Anatolian skull, a case of bilateral elongation of mandibular coronoid process was presented. Levandoski panographic analysis was performed on the panoramic radiographie to determine the hyperplasia of the coronoid process. The right condylar process was exactly hyperplastic. The measurements of Kr-Go/Cd-Go were 95...
September 2016: Anatomy & Cell Biology
Céline Crouvisier
Céline Crouvisier always knew she wanted to work with babies and resolved to apply herself in secondary school in order to be able to go on to train as a child health nurse.
October 2016: Revue de L'infirmière
Liwen Qiang, Meng Chen, Ling-Yan Zhu, Wei Wu, Qiang Wang
As one of the most popular carbon-based nano-materials, graphene oxide (GO) has the potential to be released in aquatic environment and interact with some coexistent organic pollutants, such as perfluorooctane sulfonate (PFOS), which is an emerging persistent organic pollutant. In this study, the adsorption of PFOS on GO in presence of fulvic acid (FA), the impacts of GO and FA on PFOS toxicokinetics in carp (Cyprinus carpio), and in vitro digestion behaviors were examined. The results indicated that PFOS could be strongly adsorbed on GO with a Freundlich affinity coefficient KF of 580 ± 205 (mg/g)/(mg/L)n, while the adsorption was suppressed by FA due to competitive adsorption...
October 10, 2016: Environmental Science & Technology
Christine Ceci, Mary Ellen Purkis, Francine Wynn
This paper is a written version of a talk given at the 19(th) International Philosophy of Nursing conference to honour the contributions of Dr. John S. Drummond, nurse and philosopher, to an ongoing and collective project we could call 'thinking nursing'. Over the course of his career, John Drummond published a series of essays, building on his reading of the works of continental philosophers such as Nietzsche, Lyotard or Deleuze, that draw us to nursing as a matter of concern, and that through their incisive analyses, help us to pay attention to the changes that are going on with nursing now...
October 6, 2016: Nursing Philosophy: An International Journal for Healthcare Professionals
Christian Grov, H Jonathon Rendina, Ruben Jimenez, Jeffrey T Parsons
Given the ongoing HIV epidemic, it is essential to identify gay and bisexual men who are interested in starting PrEP as well as active PrEP users. We report on online survey data gathered over a 17-month period in 2014-2015 from gay and bisexual men identified through six sources of recruitment (n = 2903): Facebook, a hookup website, two geosocial-sexual networking apps (herein "App 1: Pop-up ads" and "App 2: Banner ads"), and two types of listservs (one focused on general gay nightlife, and one focused on gay sex parties)...
October 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
Helen Bornaun, Elif Yartaşı Tik, Gonca Keskindemirci, Ali Ekiz, Kazım Öztarhan, Reyhan Dedeoğlu, Merih Çetinkaya
Right atrial appendage aneurysm is a very rare condition which can be asymptomatic or can cause arrhythmia or life-threatening thromboembolism. We report a case of newborn with right atrial appendage aneurysm who was diagnosed with fetal echocardiography. Anticoagulant therapy was applied to prevent thromboembolism and he is still going on follow-up without any complaint.
2016: Case Reports in Pediatrics
Alberto Acerbi, Claudio Tennie, Alex Mesoudi
The extensive use of social learning is considered a major reason for the ecological success of humans. Theoretical considerations, models and experiments have explored the evolutionary basis of social learning, showing the conditions under which learning from others is more adaptive than individual learning. Here we present an extension of a previous experimental set-up, in which individuals go on simulated 'hunts' and their success depends on the features of a 'virtual arrowhead' they design. Individuals can modify their arrowhead either by individual trial and error or by copying others...
September 2016: Royal Society Open Science
Sanne de Wit, Tim B Ziermans, M Nieuwenhuis, Patricia F Schothorst, Herman van Engeland, René S Kahn, Sarah Durston, Hugo G Schnack
An important focus of studies of individuals at ultra-high risk (UHR) for psychosis has been to identify biomarkers to predict which individuals will transition to psychosis. However, the majority of individuals will prove to be resilient and go on to experience remission of their symptoms and function well. The aim of this study was to investigate the possibility of using structural MRI measures collected in UHR adolescents at baseline to quantitatively predict their long-term clinical outcome and level of functioning...
October 4, 2016: Human Brain Mapping
Emily Gowland, Karen Le Ball, Catherine Bryant, Jonathan Birns
Acute care common stem acute medicine (ACCS AM) training was designed to develop competent multi-skilled acute physicians to manage patients with multimorbidity from 'door to discharge' in an era of increasing acute hospital admissions. Recent surveys by the Royal College of Physicians have suggested that acute medical specialties are proving less attractive to trainees. However, data on the career pathways taken by trainees completing core acute medical training has been lacking. Using London as a region with a 100% fill rate for its ACCS AM training programme, this study showed only 14% of trainees go on to higher specialty training in acute internal medicine and a further 10% to pursue higher medical specialty training with dual accreditation with internal medicine...
October 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
Qiang Matthew Zhang, Darren Berg, Jiaqi Duan, Samuel M Mugo, Michael J Serpe
Ferrocene-modified poly(N-isopropylacrylamide)-based microgels were synthesized, characterized, and used to construct optical devices (etalons). The response of the microgels and etalons to H2O2 was investigated, and we show that both the microgel diameter and the optical properties of the etalons depend on the solution concentration of H2O2 from 0.6 to 35 mM. This behavior is a direct result of the oxidation of ferrocene, which influences the microgel diameter. This was also demonstrated by electrochemical-mediated oxidation/reduction of ferrocene using cyclic voltammetry...
October 12, 2016: ACS Applied Materials & Interfaces
Sachin Goyal, Pratima Nangia-Makker, Lulu Farhana, Yingjie Yu, Adhip Pn Majumdar
Over the past two decades there has been remarkable progress in cancer diagnosis, treatment and screening. The basic mechanisms leading to pathogenesis of various types of cancers are also understood better and some patients, if diagnosed at a particular stage go on to lead a normal pre-diagnosis life. Despite these achievements, racial disparity in some cancers remains a mystery. The higher incidence, aggressiveness and mortality of breast, prostate and colorectal cancers (CRCs) in African-Americans as compared to Caucasian-Americans are now well documented...
September 26, 2016: World Journal of Stem Cells
Thusa Sabapathy, Douglas L Vanderbilt, Irina Zamora, Marilyn Augustyn
Juanita is a 13-year-old non-verbal Latina girl with autism spectrum disorder, moderate intellectual disability, and a seizure disorder whose aggressive behaviors toward her parents have significantly worsened over the past few months.Juanita's monolingual Spanish-speaking parents are here today for medication management at her primary care clinic. The parents report that Juanita pinches them, pulls their hair, and hits her head with her fists. Her aggression toward them is usually triggered by feelings of frustrations, leaving her parents feeling like they have to walk on eggshells around her and have led to differing parenting styles...
October 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
Kristina Woodard, Lila R Gleitman, John C Trueswell
A child word-learning experiment is reported that examines 2- and 3-year-olds' ability to learn the meanings of novel words across multiple, referentially ambiguous, word occurrences. Children were told they were going on an animal safari in which they would learn the names of unfamiliar animals. Critical trial sequences began with hearing a novel word (e.g., "I see a dax! Point to the dax!") while seeing photos of two unfamiliar animals. After responding and performing on two filler trials with known animals, participants encountered the novel word again ("I see another dax! Point to the dax!") in one of two experimental conditions...
2016: Language Learning and Development: the Official Journal of the Society for Language Development
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