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https://www.readbyqxmd.com/read/28428222/evidence-based-medicine-these-7%C3%A2-years-time-for-the-editor-to-go-on-permanent-sabbatical
#1
EDITORIAL
Richard Saitz
No abstract text is available yet for this article.
April 20, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28426296/a-typical-day-with-mild-cognitive-impairment
#2
Tigist Hailu, Carolyn C Cannuscio, Roxanne Dupuis, Jason Karlawish
For years Bob worried something was wrong with his memory. He expressed this worry to his family physician, who told him memory loss is a normal part of aging. "All these years that I've known that something was going on in my brain, I can see a curve," said Bob. "It's always been a pretty steady curve going slowly downhill." (Am J Public Health. Published online ahead of print April 20, 2017: e1-e2. doi:10.2105/AJPH.2017.303752).
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28421957/what-the-student-saw-sharing-placement-experiences-to-improve-practice
#3
Jennifer Trueland
When nursing students go on clinical placement they see patient safety practice in action - good and bad.
April 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28417633/ph-responsive-graphene-oxide-dna-nano-system-for-living-cell-imaging-and-detection
#4
Chen Shao, Jia Liang, Sihui He, Tianqi Luan, Jiantao Yu, Haoran Zhao, Jingyuan Xu, Leilei Tian
The interaction between GO and DNA is very sensitive to the environment. For example, under the acidic condition, the affinity from GO to DNA will be enhanced, weakening the capability of GO on distinguishing DNAs with different confor-mations. Such effect impedes the development of sensitive pH biosensors based on GO-DNA nano-systems. In this work, we systematically studied the affinity between GO and i-motif forming oligonucleotides (IFOs) under different pH values and developed a herring sperm DNA (HSD) treatment method...
April 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28416948/comparative-analysis-of-predicted-gene-expression-among-crenarchaeal-genomes
#5
Shibsankar Das, Brajadulal Chottopadhyay, Satyabrata Sahoo
Research into new methods for identifying highly expressed genes in anonymous genome sequences has been going on for more than 15 years. We presented here an alternative approach based on modified score of relative codon usage bias to identify highly expressed genes in crenarchaeal genomes. The proposed algorithm relies exclusively on sequence features for identifying the highly expressed genes. In this study, a comparative analysis of predicted highly expressed genes in five crenarchaeal genomes was performed using the score of Modified Relative Codon Bias Strength (MRCBS) as a numerical estimator of gene expression level...
March 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/28416424/-first-requests-for-a-regional-pediatric-palliative-care-team-a-prospective-and-observational-study
#6
L Marty, F Bernard, M Pierre, S Bringuier-Branchereau, N Sirvent, A Ribrault
INTRODUCTION: In France, 26 regional pediatric palliative care teams (ERRSPP) were created between 2008 and 2012. We conducted the first prospective French study to describe the main specifications of the initial contact with an ERRSPP and to analyze the responses given. DESIGN AND METHODS: All the requests for interventions on the part of the ERRSPP were collected between September 2013 and September 2014. We prospectively completed a questionnaire on the patient's clinical and demographic data (age, sex, disease), details regarding the request (type of applicant, unit's specialty, request pattern), and the answers provided (interval between diagnosis and request, duration of care by ERRSPP, death, changes compared to the initial request)...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28405691/-customised-early-mobilisation-how-about-a%C3%A2-little-bit-more
#7
S Nessizius
Early mobilisation of patients in intensive care starts in a multiprofessional team with passive techniques continuing with assistive measures and finally going on to active training including mobilisation leading to sitting and standing positions as well as walking. Positive effects regarding these procedures have been proved in numerous studies and can also be found in the revision of the S2e guideline "Positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders". In order to work with regard to the resources of the patient in intensive care, of the multiprofessional team, of the ward-specific structures and of the used equipment it is vital to apply a customised mobilisation concept...
April 12, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28403859/managing-uncertainty-a-qualitative-study-of-surgeons-decision-making-for-one-stage-and-two-stage-revision-surgery-for-prosthetic-hip-joint-infection
#8
Andrew J Moore, Ashley W Blom, Michael R Whitehouse, Rachael Gooberman-Hill
BACKGROUND: Approximately 88,000 primary hip replacements are performed in England and Wales each year. Around 1% go on to develop deep prosthetic joint infection. Between one-stage and two-stage revision arthroplasty best treatment options remain unclear. Our aims were to characterise consultant orthopaedic surgeons' decisions about performing either one-stage or two-stage revision surgery for patients with deep prosthetic infection (PJI) after hip arthroplasty, and to identify whether a randomised trial comparing one-stage with two-stage revision would be feasible...
April 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28401016/data-mining-and-medical-world-breast-cancers-diagnosis-treatment-prognosis-and-challenges
#9
Rozita Jamili Oskouei, Nasroallah Moradi Kor, Saeid Abbasi Maleki
The amount of data in electronic and real world is constantly on the rise. Therefore, extracting useful knowledge from the total available data is very important and time consuming task. Data mining has various techniques for extracting valuable information or knowledge from data. These techniques are applicable for all data that are collected inall fields of science. Several research investigations are published about applications of data mining in various fields of sciences such as defense, banking, insurances, education, telecommunications, medicine and etc...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28398879/parthenolide-selectively-sensitizes-prostate-tumor-tissue-to-radiotherapy-while-protecting-healthy-tissues-in-vivo
#10
Katherine L Morel, Rebecca J Ormsby, Eva Bezak, Christopher J Sweeney, Pamela J Sykes
Radiotherapy is widely used in cancer treatment, however the benefits can be limited by radiation-induced damage to neighboring normal tissues. Parthenolide (PTL) exhibits anti-inflammatory and anti-tumor properties and selectively induces radiosensitivity in prostate cancer cell lines, while protecting primary prostate epithelial cell lines from radiation-induced damage. Low doses of radiation have also been shown to protect from subsequent high-dose-radiation-induced apoptosis as well as DNA damage. These properties of PTL and low-dose radiation could be used to improve radiotherapy by killing more tumor cells and less normal cells...
March 3, 2017: Radiation Research
https://www.readbyqxmd.com/read/28398680/cytomegalovirus-infection-in-pregnancy
#11
REVIEW
Nicole L Davis, Caroline C King, Athena P Kourtis
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28395523/adverse-drug-reactions-reporting-in-calabria-southern-italy-in-the-four-year-period-2011-2014-impact-of-a-regional-pharmacovigilance-project-in-light-of-the-new-european-legislation
#12
Christian Leporini, Giuseppina Marrazzo, Laura Mumoli, Stefania Esposito, Luca Gallelli, Giovanna Mangano, Giacomino Brancati, Emanuela Adele De Francesco, Emilio Russo, Giovambattista De Sarro
BACKGROUND: The number of suspected adverse drug reactions (ADRs) yearly submitted to the Italian Network of Pharmacovigilance (RNF) has progressively increased after the new European Pharmacovigilance legislation (July 2012). These results have mostly reflected the agreements between Italian Medicines Agency (AIFA) and Italian Regions, enabling the implementation of active pharmacovigilance projects. A project was funded by the AIFA in Calabria region (Southern Italy) in 2010 to increase ADRs reporting and promote a safer medicines' use...
April 11, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28388168/on-the-structure-and-dynamics-of-water-associated-with-single-supported-zwitterionic-and-anionic-membranes
#13
A Miskowiec, Z N Buck, F Y Hansen, H Kaiser, H Taub, M Tyagi, S O Diallo, E Mamontov, K W Herwig
We have used high-resolution quasielastic neutron scattering (QENS) to investigate the dynamics of water molecules (time scale of motion ∼10(-11)-10(-9) s) in proximity to single-supported bilayers of the zwitterioniclipid DMPC (1,2-dimyristoyl-sn-glycero-3-phosphorylcholine) and the anionic lipid DMPG (1,2-dimyristoyl-sn-glycero-3-phosphoglycerol) in the temperature range 160-295 K. For both membranes, the temperature dependence of the intensity of neutronsscattered elastically and incoherently from these samples indicates a series of freezing/melting transitions of the membrane-associated water, which have not been observed in previous studies of multilayer membranes...
March 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28386368/diffusional-kurtosis-imaging-in-evaluating-the-secondary-change-of-corticospinal-tract-after-unilateral-cerebral-infarction
#14
Shun Zhang, Wenjie Zhu, Yan Zhang, Yihao Yao, Jingjing Shi, Cong-Yi Wang, Wenzhen Zhu
We investigated to evaluate whether diffusional kurtosis imaging (DKI) can early detect the microstructure change of corticospinal tract (CST) after unilateral cerebral infarction solely in middle cerebral artery (MCA) territory. Seventy-seven patients with MCA territory infarct consisting of 10 subjects of hyperacute phase, 22 subjects of acute phase, 28 subjects of subacute phase and 17 subjects of chronic phase were enrolled in this study. ROI method was performed to measure the mean value of the infarcted area and the areas which belongs to CST [including the posterior limb of internal capsule (PLIC), cerebral peduncle (CP), pons, and medulla] in both ipsilateral and contralateral mirror side in all the DKI-derived parametric maps...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28373381/oblique-wrinkles
#15
M Carfagna, M Destrade, A L Gower, A Grillo
We prove theoretically that when a soft solid is subjected to an extreme deformation, wrinkles can form on its surface at an angle that is oblique to a principal direction of stretch. These oblique wrinkles occur for a strain that is smaller than the one required to obtain wrinkles normal to the direction of greatest compression. We go on to explain why they will probably never be observed in real-world experiments.This article is part of the themed issue 'Patterning through instabilities in complex media: theory and applications...
May 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28370773/a-dnazyme-feedback-amplification-strategy-for-biosensing
#16
Meng Liu, Qiang Zhang, Dingran Chang, Jimmy Gu, John D Brennan, Yingfu Li
We report a signal amplification strategy termed DNAzyme feedback amplification (DFA) that takes advantage of rolling-circle amplification (RCA) and an RNA-cleaving DNAzyme (RCD). DFA employs two specially programmed DNA complexes, one composed of a primer and a circular template containing the antisense sequence of an RCD, and the other composed of the same circular template and an RNA-containing substrate for the RCD. RCA is initiated at the first complex to produce RCD elements that go on to cleave the substrate in the second complex...
March 28, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28370172/a-qualitative-exploration-of-the-experiences-of-patients-with-breast-cancer-receiving-outpatient-based-chemotherapy
#17
Xiao Bin Lai, Shirley Siu Yin Ching, Frances Kam Yuet Wong
AIMS: To understand the experiences of patients with breast cancer and their involvement during outpatient-based chemotherapy in Hong Kong. BACKGROUND: The outcome evaluation using a mixed-methods approach is not common in interventional studies of nurse-led chemotherapy care programmes. A qualitative approach could provide a deep understanding of the experiences of patients. DESIGN: A qualitative study was conducted. METHODS: This is part of a randomized controlled trial of a nurse-led care programme (NCT02228200)...
March 31, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28368147/the-three-second-subjective-present-a-critical-review-and-a-new-proposal
#18
Peter A White
It has been argued that there is a "subjective present" or "experienced moment" of about 3 seconds in duration, involving automatic binding of events into perceptual units on that time scale. Research on topics that have been taken as relevant to this proposal is reviewed. The topics include accuracy in reproduction of stimulus durations, synchronization of behavior with a regular beat, mental rhythmization of a regular beat, time units in behavior, segmentation of observed behavior into meaningful units, time scale of reversals of perception with bistable ambiguous figures, time scale of inhibition of return in visual search, and EEG responses to deviant stimuli in series of repeating stimuli...
April 3, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28365563/pedestrian-inattention-blindness-while-playing-pok%C3%A3-mon-go-as-an-emerging-health-risk-behavior-a-case-report
#19
Stefania Barbieri, Gianna Vettore, Vincenzo Pietrantonio, Rossella Snenghi, Alberto Tredese, Mauro Bergamini, Sara Previato, Armando Stefanati, Rosa Maria Gaudio, Paolo Feltracco
BACKGROUND: Cases of trauma resulting from the use of mobile phones while driving motor vehicles have become quite common in recent years. Road injuries incurred by people playing video games on mobile phones (or other media devices) while walking have also become a cause for concern. Pokémon Go has been the world's most popular game since it was launched in July 2016, with more than 15 million players trying to catch all Pokémon available in the game; however, the case detailed here is the first reported accident in the medical literature caused by a pedestrian distracted by the game while crossing a street...
April 1, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28365511/influence-of-graphene-oxide-on-the-transport-and-deposition-behaviors-of-colloids-in-saturated-porous-media
#20
Shengnan Peng, Dan Wu, Zhi Ge, Meiping Tong, Hyunjung Kim
The effects of graphene oxide (GO) on the transport and deposition behaviors of colloids with different sizes in packed quartz sand were investigated in both NaCl (10 and 50 mM) and CaCl2 solutions (1 and 5 mM) at pH 6. Fluorescent carboxylate-modified polystyrene latex microspheres (CMLs) with size ranging from 0.2 to 2 μm were utilized as model colloids. Both breakthrough curves and retained profiles of colloids in the presence and absence of GO in suspensions under all examined solution conditions were analyzed...
March 30, 2017: Environmental Pollution
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