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https://www.readbyqxmd.com/read/29139262/-effect-of-different-fertilization-treatments-on-yield-and-secondary-metabolites-of-codonopsis-pilosula
#1
Jia-Dong Hu, Ge Mao, Zhi-Wei Zhang, Cun-de Ma, Zong-Suo Liang, Guang-Dong Xia, Juan-E Dong
The research studies the effect of different fertilization treatments on yield and accumulation of secondary metabolites of Codonopsis pilosula by using single factor randomized block design, in order to ensure reasonable harvesting time and fertilization ratio, and provide the basis for standardized cultivation of C. pilosula. According to the clustering results, the nitrogen fertilizer benefitted for the improvement of root diameter and biomass of C. pilosula. The phosphate fertilizer could promote the content of C...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#2
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29137888/comparative-effects-of-graphene-and-graphene-oxide-on-copper-toxicity-to-daphnia-magna-role-of-surface-oxygenic-functional-groups
#3
Yingying Liu, Wenhong Fan, Zhizhen Xu, Weihua Peng, Shenglian Luo
Although the risk of graphene materials to aquatic organisms has drawn wide attention, the combined effects of graphene materials with other contaminants such as toxic metals, which may bring about more serious effects than graphene materials alone, have seldom been explored. Herein, the effects of graphene (GN) and graphene oxide (GO, an important oxidized derivative of graphene) on copper (Cu) toxicity to Daphnia magna were systematically investigated. The results indicated that GN remarkably increased the Cu accumulation in D...
November 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29137156/digital-platforms-in-the-assessment-and-monitoring-of-patients-with-bipolar-disorder
#4
REVIEW
Arvind Rajagopalan, Pooja Shah, Melvyn W Zhang, Roger C Ho
This paper aims to review the application of digital platforms in the assessment and monitoring of patients with Bipolar Disorder (BPD). We will detail the current clinical criteria for the diagnosis of BPD and the tools available for patient assessment in the clinic setting. We will go on to highlight the difficulties in the assessment and monitoring of BPD patients in the clinical context. Finally, we will elaborate upon the impact that diital platforms have made, and have the potential to make, on healthcare, mental health, and specifically the management of BPD, before going on to evaluate the benefits and drawbacks of the use of such technology...
November 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29132525/hepatitis-c-a-new-era
#5
REVIEW
Dee Ann Bragg, Ashley Crowl, Emily Manlove
More than 2 million Americans are infected with hepatitis C virus (HCV), and only about half are aware that they are infected. Primarily blood-borne, risk factors for the virus include injection or intranasal drug use, unregulated tattoos, incarceration, and blood transfusion before 1992. In addition, 75% of those with the virus were born between 1945 and 1965, thus making the baby-boomer cohort a population of screening interest. Because acute and early chronic HCV are often asymptomatic, screening of at-risk individuals is of utmost importance...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29127753/-intestinal-adaptation-following-gut-resection
#6
Jarmila Křížová, Pavel Trachta, Eva Kotrlíková
Gut resection is followed by wide changes in the gastrointestinal tract. The goal is to increase nutrient, water and mineral absorption in the remnant intestine. These changes are going on for several months. They affect gut mucosa structure, intestine peristaltic activity and enterocytes function. The crucial role is ileum preserving. Ileum has higher adaptation ability comparing to jejunum and inhibits peristaltic function of proximal parts of GIT. A lot of factors involved in intestinal adaptation were identified, hormones, growth factors, regulating peptides, intracellular signalizing cascades, cytokines and tissue factors...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29124264/laser-structured-janus-wire-mesh-for-efficient-oil-water-separation
#7
Yu-Qing Liu, Dong-Dong Han, Zhi-Zhen Jiao, Yan Liu, Hao-Bo Jiang, Xuan-Hang Wu, Hong Ding, Yong-Lai Zhang, Hong-Bo Sun
We report here the fabrication of a Janus wire mesh by a combined process of laser structuring and fluorosilane/graphene oxide (GO) modification of the two sides of the mesh, respectively, toward its applications in efficient oil/water separation. Femtosecond laser processing has been employed to make different laser-induced periodic surface structures (LIPSS) on each side of the mesh. Surface modification with fluorosilane on one side and GO on the other side endows the two sides of the Janus mesh with distinct wettability...
November 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/29114487/prevalence-of-trypanosome-infection-in-tsetse-flies-from-oji-river-and-emene-axis-of-enugu-state-nigeria-a-preliminary-report
#8
Kenechukwu Chibuike Onyekwelu, Fidelis Ebele Ejezie, Anthonius Anayochukwu Eze, Joy Ebele Ikekpeazu, Richard Chukwunonye Ezeh, Godknows Chizurumoke Edeh
Introduction: Trypanosomes are protozoan parasites of vertebrates transmitted by blood-sucking tsetse fly. Trypanosomes remain a constant threat to the lives of humans and animals throughout large regions of Africa. Aims and Objectives: This study investigated the presence, prevalence, and species of trypanosome parasite in tsetse flies caught in two areas of no previous documented history of trypanosome infection. Materials and Methods: For this purpose, 63 and 77 nonterenal tsetse flies were collected from Oji River and Emene areas of Enugu State Nigeria, respectively...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29111187/a-review-of-five-traditionally-used-anti-diabetic-plants-of-bangladesh-and-their-pharmacological-activities
#9
REVIEW
Md Rajdoula Rafe
Plants are used traditionally throughout the globe to treat various diseases. Traditionally used medicinal plants are an essential part of the health sector in Bangladesh due to its abundance of a vast source of ethno-medicine. Rural people from developing country like Bangladesh are greatly dependent on traditional source of medicine. The prevalence of diabetes mellitus is increasing from recent years; therefore various researches are going on to discover better medicine to treat this disease. This study has focused on five plants which are Andrographis paniculata, Ageratum conyzoides, Swertia chirata, Terminalia arjuna, and Azadirachta indica to find out their traditional formulation as anti-diabetic medicine and their pharmacological activity has also been explored through literature search...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29108524/clinical-predictors-of-conversion-to-bipolar-disorder-in-a-prospective-longitudinal-familial-high-risk-sample-focus-on-depressive-features
#10
Andrew Frankland, Gloria Roberts, Ellen Holmes-Preston, Tania Perich, Florence Levy, Rhoshel Lenroot, Dusan Hadzi-Pavlovic, Michael Breakspear, Philip B Mitchell
BACKGROUND: Identifying clinical features that predict conversion to bipolar disorder (BD) in those at high familial risk (HR) would assist in identifying a more focused population for early intervention. METHOD: In total 287 participants aged 12-30 (163 HR with a first-degree relative with BD and 124 controls (CONs)) were followed annually for a median of 5 years. We used the baseline presence of DSM-IV depressive, anxiety, behavioural and substance use disorders, as well as a constellation of specific depressive symptoms (as identified by the Probabilistic Approach to Bipolar Depression) to predict the subsequent development of hypo/manic episodes...
November 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29104706/talking-about-looks
#11
Kathrin Glüer
In natural language, looks-talk is used in a variety of ways. I investigate three uses of 'looks' that have traditionally been distinguished - epistemic, comparative, and phenomenal 'looks' - and endorse and develop considerations in support of the view that these amount to polysemy. Focusing on the phenomenal use of 'looks', I then investigate connections between its semantics, the content of visual experience, and the metaphysics of looks. I argue that phenomenal 'looks' is not a propositional attitude operator: We do not use it to ascribe propositional attitudes to subjects, but to directly ascribe looks to objects, where looks are relational properties...
2017: Review of Philosophy and Psychology
https://www.readbyqxmd.com/read/29103389/robert-boyle-and-the-representation-of-imperceptible-entities
#12
Alexander Wragge-Morley
In this essay, I examine Robert Boyle's strategies for making imperceptible entities accessible to the senses. It is well known that, in his natural philosophy, Boyle confronted the challenge of making imperceptible particles of matter into objects of sensory experience. It has never been noted, however, that Boyle confronted a strikingly similar challenge in his natural theology - he needed to make an equally imperceptible God accessible to the senses. Taking this symmetrical difficulty as my starting point, I propose a new approach to thinking about the interconnections between Boyle's natural philosophy and natural theology...
November 6, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/29101232/isopeptide-and-ester-bond-ubiquitination-both-regulate-degradation-of-the-human-dopamine-receptor-4
#13
Jennifer C Peeler, Sophia Schedin-Weiss, Mariluz Soula, Manija A Kazmi, Thomas P Sakmar
How an optimal level of human dopamine D4 receptor (hD4R) is maintained in synaptic membranes is not known. We show here that hD4R is ubiquitinated in primary neurons. We go on to show that ubiquitin is attached to hD4R through isopeptide and ester bonds. When lysine (Lys) residues of the hD4R are substituted with arginine (Arg) residues, cellular D4R protein levels increase. A synergistic effect on D4R levels is noted when cytoplasmic serine (Ser) and threonine (Thr) residues are mutated. Chloroquine, an inhibitor of lysosomal degradation, did not have an effect on hD4R protein levels...
November 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29098417/low-intrathecal-antibody-production-despite-high-seroprevalence-of-epstein-barr-virus-in-multiple-sclerosis-a-review-of-the-literature
#14
REVIEW
Klemens Ruprecht, Brigitte Wildemann, Sven Jarius
BACKGROUND: Patients with multiple sclerosis (MS) frequently have an intrathecal production of antibodies to different common viruses, which can be detected by elevated antiviral antibody indices (AIs). There is a strong and consistent association of MS and Epstein-Barr virus (EBV) infection. OBJECTIVE: To systematically compare the frequencies of intrathecal antibody production to EBV, measles virus, rubella virus, varicella zoster virus (VZV) and herpes simplex virus (HSV) in patients with MS...
November 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29098157/identification-and-characterization-of-oleaginous-yeast-isolated-from-kefir-and-its-ability-to-accumulate-intracellular-fats-in-deproteinated-potato-wastewater-with-different-carbon-sources
#15
Iwona Gientka, Marek Kieliszek, Karolina Jermacz, Stanisław Błażejak
The search for efficient oleaginous microorganisms, which can be an alternative to fossil fuels and biofuels obtained from oilseed crops, has been going on for many years. The suitability of microorganisms in this regard is determined by their ability to biosynthesize lipids with preferred fatty acid profile along with the concurrent utilization of energy-rich industrial waste. In this study, we isolated, characterized, and identified kefir yeast strains using molecular biology techniques. The yeast isolates identified were Candida inconspicua, Debaryomyces hansenii, Kluyveromyces marxianus, Kazachstania unispora, and Zygotorulaspora florentina...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29096386/cannabis-induced-psychosis-and-subsequent-psychiatric-disorders
#16
Dharav Shah, Prabhat Chand, Mrunal Bandawar, Vivek Benegal, Pratima Murthy
INTRODUCTION: Long term change in diagnosis of patients having Cannabis induced psychosis (CIP) at the index evaluation is well recognised. Some patients are known to achieve complete remission while others go on to develop independent schizophrenia or mood disorders. AIMS: To study the long-term course of CIP and factors influencing it. METHOD: Patients diagnosed as CIP (ICD 10: F12.5), admitted at NIMHANS, a tertiary neuropsychiatry centre at Bangalore, over the past 10 years were identified from medical records...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29090921/two-step-electrochemical-intercalation-and-oxidation-of-graphite-for-the-mass-production-of-graphene-oxide
#17
Jianyun Cao, Pei He, Mahdi A Mohammed, Xin Zhao, Robert J Young, Brian Derby, Ian A Kinloch, Robert A W Dryfe
Conventional chemical oxidation routes for the production of graphene oxide (GO), such as the Hummers method, suffer from environmental and safety issues due to their use of hazardous and explosive chemicals. These issues are addressed by electrochemical oxidation methods but such approaches typically have a low yield due to inhomogeneous oxidation. Herein we report a two-step electrochemical intercalation and oxidation approach to produce GO on a large laboratory scale (ten's of grams) comprising: (1) forming a stage 1 graphite intercalation compound (GIC) in concentrated sulfuric acid; (2) oxidizing and exfoliating the stage 1 GIC in an aqueous solution of 0...
November 1, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29073657/is-cardiomegaly-on-chest-radiograph-representative-of-true-cardiomegaly-a-cross-sectional-observational-study-comparing-cardiac-size-on-chest-radiograph-to-that-on-echocardiography
#18
COMPARATIVE STUDY
Jane L McKee, Katherine Ferrier
AIMS: To determine whether or not cardiomegaly identified on chest radiograph (CXR) is indicative of true cardiomegaly as determined using echocardiography (echo) as the gold standard tool, and therefore whether or not cardiomegaly on CXR should be investigated further. METHODS: CXR and echocardiogram reports were reviewed for the presence of cardiomegaly in a population following non-ST segment elevation myocardial infarction (NSTEMI). Data was evaluated to determine whether cardiomegaly reported on CXR did indeed represent true cardiomegaly...
October 27, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29068037/berg-balance-scale-score-at-admission-can-predict-walking-suitable-for-community-ambulation-at-discharge-from-inpatient-stroke-rehabilitation
#19
Dennis R Louie, Janice J Eng
OBJECTIVE: This retrospective cohort study identified inpatient rehabilitation admission variables that predict walking ability at discharge and established Berg Balance Scale cut-off scores to predict the extent of improvement in walking. METHODS: Participants (n=123) were assessed for various cognitive and physical outcomes at admission to inpatient stroke rehabilitation. Multivariate logistic regression identified admission predictors of regaining community ambulation (gait speed ≥0...
October 25, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29067602/prophylactic-cholecystectomy-at-time-of-surgery-for-small-bowel-neuroendocrine-tumor-does-not-increase-postoperative-morbidity
#20
Andrew J Sinnamon, Madalyn G Neuwirth, Charles C Vining, Catherine E Sharoky, Yu-Xiao Yang, Rachel R Kelz, Douglas L Fraker, Robert E Roses, Giorgos C Karakousis
BACKGROUND: Prophylactic cholecystectomy at time of surgery for small bowel neuroendocrine tumor (SBNET) has been advocated, as these patients often go on to require somatostatin analogue therapy, which is known to increase risk of cholestasis and associated complications. Little is known regarding patterns of adoption of this practice or its associated morbidity. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database (2008-2014) was queried to identify patients who underwent SBNET resection...
October 24, 2017: Annals of Surgical Oncology
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