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https://www.readbyqxmd.com/read/28793814/being-mindful-as-a-phenomenological-attitude
#1
Lena Wiklund Gustin
PURPOSE: The purpose of this article is to reflect on being mindful as a phenomenological attitude rather than on describing mindfulness as a therapeutic intervention. I will also explore the possibilities that being mindful might open up in relation to nursing research and holistic nursing. DESIGN AND METHOD: I will describe and interpret mindfulness as a state of being by means of van Manen's phenomenological method, using the language of phenomenology rather than the language of reductionist science...
August 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/28792113/the-role-of-a-family-history-of-psychosis-for-youth-at-clinical-high-risk-of-psychosis
#2
Grace Georgopoulos, Jacqueline Stowkowy, Lu Liu, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel H Mathalon, Jean Addington
AIM: On average, there is a 10% to 12% likelihood of developing a psychotic disorder solely based on being at familial high risk. However, the introduction of the criteria for clinical high risk (CHR) of psychosis suggested for CHR individuals, 20% to 30% will go on to develop a full-blown psychotic illness within 3 years. Several studies suggest a role for family history in conversion to psychosis among those at CHR. However, we know very little about those who meet the CHR criteria and have a positive family history for psychosis compared to those at CHR with no known family history...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28774194/vulnerability-for-alcohol-use-disorder-and-rate-of-alcohol-consumption
#3
Joshua L Gowin, Matthew E Sloan, Bethany L Stangl, Vatsalya Vatsalya, Vijay A Ramchandani
OBJECTIVE: Although several risk factors have been identified for alcohol use disorder, many individuals with these factors do not go on to develop the disorder. Identifying early phenotypic differences between vulnerable individuals and healthy control subjects could help identify those at higher risk. Binge drinking, defined as reaching a blood alcohol level of 80 mg%, carries a risk of negative legal and health outcomes and may be an early marker of vulnerability. Using a carefully controlled experimental paradigm, the authors tested the hypothesis that risk factors for alcohol use disorder, including family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would predict rate of binging during an individual alcohol consumption session...
August 4, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28770328/metformin-and-ageing-improving-ageing-outcomes-beyond-glycaemic-control
#4
REVIEW
Willy Marcos Valencia, Ana Palacio, Leonardo Tamariz, Hermes Florez
In a world where the population is ageing, there is growing interest and demand for research evaluating strategies that address the ageing process. After 60 years of successful use of metformin in our pharmaceutical armamentarium, we are learning that, beyond improving glycaemic control, metformin may have additional mechanisms and pathways of action that need further study. Although, metformin's effect on clinical ageing outcomes may still be considered speculative, the findings from studies into cellular and animal models and from observational and pilot human studies support the existence of beneficial effects on ageing...
August 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/28766395/dual-loyalties-everyday-ethical-problems-of-registered-nurses-and-physicians-in-combat-zones
#5
Kristina Lundberg, Sofia Kjellström, Lars Sandman
BACKGROUND: When healthcare personnel take part in military operations in combat zones, they experience ethical problems related to dual loyalties, that is, when they find themselves torn between expectations of doing caring and military tasks, respectively. AIM: This article aims to describe how Swedish healthcare personnel reason concerning everyday ethical problems related to dual loyalties between care and military tasks when undertaking healthcare in combat zones...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28754471/how-to-train-your-inhibitor-design-strategies-to-overcome-resistance-to-epidermal-growth-factor-receptor-inhibitors
#6
REVIEW
Sandra N Milik, Deena S Lasheen, Rabah A T Serya, Khaled A M Abouzid
Epidermal Growth Factor Receptor (EGFR) stands out as a key player in the development of many cancers. Its dysregulation is associated with a vast number of tumors such as non-small-cell lung cancer, colon cancer, head-and-neck cancer, breast and ovarian cancer. Being implicated in the development of a number of the most lethal cancers worldwide, EGFR has long been considered as a focal target for cancer therapies, ever since the FDA approval of "Gefitinib" in 2003 and up to the last FDA approved small molecule EGFR kinase inhibitor "Osimertinib" in 2015...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28751481/recruitment-and-retention-in-a-10-month-social-network-based-intervention-promoting-diabetes-self-management-in-socioeconomically-deprived-patients-a-qualitative-process-evaluation
#7
Charlotte Vissenberg, Vera Nierkens, Paul J M Uitewaal, Barend J C Middelkoop, Karien Stronks
OBJECTIVES: Socioeconomically deprived patients with type 2 diabetes often face challenges with self-management, resulting in more diabetes-related complications. However, these groups are often under-represented in self-management interventions. Evidence on effective recruitment and retention strategies is growing, but lacking for intensive self-management interventions. This study aims to explore recruitment, retention and effective intervention strategies in a 10-month group-based intervention among Dutch, Moroccan, Turkish and Surinamese patients from socioeconomically deprived neighbourhoods...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28750021/dynamics-and-asymmetry-in-the-dimer-of-the-norovirus-major-capsid-protein
#8
Thibault Tubiana, Yves Boulard, Stéphane Bressanelli
Noroviruses are the major cause of non-bacterial acute gastroenteritis in humans and livestock worldwide, despite being physically among the simplest animal viruses. The icosahedral capsid encasing the norovirus RNA genome is made of 90 dimers of a single ca 60-kDa polypeptide chain, VP1, arranged with T = 3 icosahedral symmetry. Here we study the conformational dynamics of this main building block of the norovirus capsid. We use molecular modeling and all-atom molecular dynamics simulations of the VP1 dimer for two genogroups with 50% sequence identity...
2017: PloS One
https://www.readbyqxmd.com/read/28744894/external-national-validation-of-the-leicester-self-assessment-score-for-type-2-diabetes-using-data-from-the-english-longitudinal-study-of-ageing
#9
S R Barber, N N Dhalwani, M J Davies, K Khunti, L J Gray
AIMS: To validate the Leicester Self-Assessment score using a representative English dataset for detecting prevalent non-diabetic hyperglycaemia or undiagnosed Type 2 diabetes (defined as HbA1c ≥6.0%) and for identifying those who may go on to develop Type 2 diabetes within 10 years. METHODS: Data were taken from the English Longitudinal Study of Ageing, a nationally representative dataset of people aged ≥50 years. The area under the receiver-operator curve and performance metrics for the score at the recommended score threshold (≥16), were calculated for the outcomes of HbA1c ≥42 mmol/mol (6...
July 26, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28739527/deconstructing-the-cortical-column-in-the-barrel-cortex
#10
Kevin Fox
The question of what function is served by the cortical column has occupied neuroscientists since its original description some 60 years ago. The answer seems tractable in the somatosensory cortex when considering the inputs to the cortical column and the early stages of information processing, but quickly breaks down once the multiplicity of output streams and their sub-circuits are brought into consideration. This article describes the early stages of information processing in the barrel cortex, through generation of the centre and surround receptive field components of neurones that subserve integration of multi whisker information, before going on to consider the diversity of properties exhibited by the layer 5 output neurones...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28735586/cognitive-development-prior-to-onset-of-psychosis
#11
J Mollon, A Reichenberg
Schizophrenia patients commonly exhibit substantial and diffuse cognitive impairment. Evidence suggests that subtle cognitive deficits are already apparent in childhood and adolescence, many years prior to onset of psychosis. While there is almost unequivocal evidence of some degree of cognitive impairment in individuals who later develop schizophrenia, the literature remains inconclusive regarding the exact nature of this impairment and warrants careful review and interpretation. Meta-analytic findings suggest that individuals who later develop schizophrenia, but not related disorders, such as bipolar disorder, exhibit a premorbid IQ deficit of around 8 points...
July 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28735235/linear-solvation-energy-relationship-to-predict-the-adsorption-of-aromatic-contaminants-on-graphene-oxide
#12
Sujie Shan, Ying Zhao, Huan Tang, Fuyi Cui
In this study, adsorption capability of aromatic contaminants on graphene oxide (GO) was predicted using linear solvation energy relationship (LSER) model for the first time. Adsorption data of 44 aromatic compounds collected from literature and our experimental results were used to establish LSER models with multiple linear regression. High value of R(2) (0.919), strong robustness (QLoo(2) = 0.862), and desirable predictability (Qext(2) = 0.834) demonstrated the model worked well for predicting the adsorption of small aromatic contaminants (descriptor V<3...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28733886/cognitive-reappraisal-and-depression-in-children-with-a-parent-history-of-depression
#13
Anastacia Y Kudinova, Kiera James, Brandon E Gibb
Although decades of research have documented that children whose parents have a history of Major Depressive Disorder (MDD) are at a higher risk of developing depression themselves, not all of these children go on to develop depression themselves, thus highlighting the need to understand potential moderators of risk. The current study examined whether child emotion regulation, specifically, the use of cognitive reappraisal and suppression, moderated the link between parent and child depression. We recruited 458 parents and their children between the ages of 7-11 from the community...
July 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28729782/holding-strength-of-suture-an-experimental-study-using-porcine-kidney
#14
Ünsal Özkuvanci, Haluk Akpinar, Mert Ali Karadag, Muhammet İrfan Dönmez, Fatih Altunrende
BACKGROUND AND OBJECTIVES: The search for the perfect suture is going on and has resulted in the introduction of many different suture types into the market. The purpose of this study is to investigate the holding strength (HS) of different sutures in the renal parenchyma in an experimental study on pig kidneys. METHODS: The HS that caused sliding of the suture was investigated in 5 adult porcine kidneys with 7 suture variants. HS-caused tearing of the kidney was investigated with 3 suture types on 5 kidneys...
July 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28726008/the-trouble-with-collective-nouns-for-genome-editing
#15
Sara Wells, Jean Stéphane Joly
We should start as we mean to go on and try to avoid the confusion most of us experience when bombarded with acronyms with overstated significations. You will be familiar with the situation, you are in a seminar or a meeting and someone who has been using a set of acronyms for years, includes them in sentence after sentence that has you lost because you don't know what some or most of them stand for. Even worse when scientists start making verbs out of them, CRISPR seems to have fallen into this category; how many of us have heard someone asking if a mutation can be CRISPRed! Does it matter though? We are all familiar with informal language in scientific talks and discussions which is replaced by more formal dialect when research is published or presented to the general public...
July 18, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28725289/amnestic-mci-patients-perspectives-toward-disclosure-of-amyloid-pet-results-in-a-research-context
#16
Gwendolien Vanderschaeghe, Jolien Schaeverbeke, Rik Vandenberghe, Kris Dierickx
BACKGROUND: Researchers currently are not obligated to share individual research results (IRR) with participants. This non-disclosure policy has been challenged on the basis of participants' rights to be aware and in control of their personal medical information. Here, we determined how patients view disclosure of research PET results of brain amyloid and why they believe it is advantageous or disadvantageous to disclose. METHOD: As a part of a larger diagnostic trial, we conducted semi-structured interviews with patients with amnestic Mild Cognitive Impairment (aMCI)...
2017: Neuroethics
https://www.readbyqxmd.com/read/28724585/effect-of-gluten-free-diet-on-cerebellar-mr-spectroscopy-in-gluten-ataxia
#17
Marios Hadjivassiliou, Richard A Grünewald, David S Sanders, Priya Shanmugarajah, Nigel Hoggard
OBJECTIVE: To evaluate the effect of gluten free diet (GFD) on magnetic resonance spectroscopy (MRS) of the cerebellum in patients with gluten ataxia (GA). METHODS: Patients with GA, defined as sporadic ataxia with positive antigliadin antibodies in the absence of an alternative cause, routinely undergo MRS at baseline and after the introduction of GFD as part of their clinical care. We present our experience of the effect of GFD on MRS of the cerebellum. RESULTS: A total of 117 consecutive patients with GA were included in this report...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724427/curcumin-the-spicy-modulator-of-breast-carcinogenesis
#18
REVIEW
Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary, Nor Hayati Othman
Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remained unconquered and the quest for cure is still going on. Present-day strategy of breast cancer therapy and prevention is either combination of a number of drugs or a drug that modulates multiple targets. In this regard natural products are now becoming significant options. Curcumin exemplifies a promising natural anticancer agent for this purpose...
July 19, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28723997/access-to-health-care-as-a-human-right-in-international-policy-critical-reflections-and-contemporary-challenges
#19
Camilo Hernán Manchola Castillo, Volnei Garrafa, Thiago Cunha, Fernando Hellmann
Using the United Nations (UN) and its subordinate body, the World Health Organization (WHO), as a frame of reference, this article explores access to healthcare as a human right in international intergovernmental policies. First, we look at how the theme of health is treated within the UN, focusing on the concept of global health. We then discuss the concept of global health from a human rights perspective and go on to outline the debate surrounding universal coverage versus universal access as a human right, addressing some important ethical questions...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28720043/open-arthroscopic-and-percutaneous-surgical-treatment-of-lateral-epicondylitis-a-systematic-review
#20
Matthew B Burn, Ronald J Mitchell, Shari R Liberman, David M Lintner, Joshua D Harris, Patrick C McCulloch
BACKGROUND: Approximately 10% of patients with lateral epicondylitis go on to have surgical treatment; however, multiple surgical treatment options exist. The purpose of this study was to review the literature for the clinical outcomes of open, arthroscopic, and percutaneous treatment of lateral epicondylitis. The authors hypothesized that the clinical outcome of all 3 analyzed surgical treatments would be equivalent. METHODS: A systematic review was performed using PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar in July 2016 to compare the functional outcome, pain, grip strength, patient satisfaction, and return to work at 1-year follow-up for open, arthroscopic, and percutaneous treatment of lateral epicondylitis...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
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