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https://www.readbyqxmd.com/read/28647120/drrc-protein-of-streptomyces-peucetius-removes-daunorubicin-from-intercalated-dnri-promoter
#1
Francis Prija, Ranjan Prasad
DrrC is a DNA-binding protein of Streptomyces peucetius that provides self-resistance against daunorubicin, the antibiotic produced by the organism. DrrC was expressed in E.coli and purified by using N-terminal MBP-tag which retained DNA-binding property in spite of the tag. Mobility shift assay confirmed the interaction of 313bp DNA that has the dnrI promoter, daunorubicin and MBP-DrrC in the presence of ATP. Biotinylated and immobilized 313bp DNA was intercalated with daunorubicin to observe the release of the drug when MBP-DrrC is allowed to act on the DNA...
September 2017: Microbiological Research
https://www.readbyqxmd.com/read/28641511/microbial-lipase-mediated-by-health-beneficial-modification-of-cholesterol-and-flavors-in-food-products-a-review
#2
Ranjana Sharma, Nivedita Sharma
BACKGROUND: The tremendous need of lipase in varied applications in biotechnological increases its economical value in food and allied industries. Lipase has an impressive number of applications viz. enhancements of flavor in food products (Cheese, butter, alcoholic beverages, milk chocolate and diet control food stuffs), detergent industry in removing oil, grease stain, organic chemical processing, textile industry, oleochemical industry, cosmetic industry and also as therapeutic agents in pharmaceutical industries...
June 14, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/28636484/bezlotoxumab-anti-toxin-b-monoclonal-antibody-to-prevent-recurrence-of-clostridium-difficile-infection
#3
Javier A Villafuerte Gálvez, Ciarán P Kelly
Clostridium difficile infection (CDI) is the most common nosocomial infection in the U.S. 25% of CDI patients go on to develop recurrent CDI (rCDI) following current standard of care (SOC) therapy, leading to morbidity, mortality and economic loss. The first passive immunotherapy drug targeting C.difficile toxin B (bezlotoxumab) has been approved recently by the FDA and EMA for prevention of rCDI. Areas covered: A body of key studies was selected and reviewed by the authors. The unmet needs in CDI care were ascertained with emphasis in rCDI, including the epidemiology, pathophysiology and current management...
June 21, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634660/should-i-convince-my-partner-to-go-on-pre-exposure-prophylaxis%C3%A2-prep-the-role-of-personal-and-relationship-factors-on-prep-related-social-control-among-gay-and-bisexual-men
#4
Steven A John, Tyrel J Starks, H Jonathon Rendina, Christian Grov, Jeffrey T Parsons
An estimated 35-68% of new HIV infections among gay, bisexual, and other men who have sex with men (GBM) are transmitted through main partnerships. Pre-exposure prophylaxis (PrEP) is highly effective in reducing HIV seroconversion, yet PrEP uptake has been modest. PrEP-naïve GBM with HIV-negative, PrEP-naïve main partners enrolled in One Thousand Strong (n = 409), a U.S. national cohort of GBM, were asked about (1) the importance of partner PrEP use and (2) their willingness to convince their partner to initiate PrEP...
June 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28633376/keeping-things-in-balance-family-experiences-of-living-with-alzheimer-s-disease
#5
Nuria Esandi, Mike Nolan, Cristina Alfaro, Ana Canga-Armayor
Background and Objectives: Historically, research, practice, and policy on Alzheimer's family care has been largely focused on dyadic relationships and the experience of burden and stress, often failing to capture the complex caring dynamics as they unfold over time. This study sought to develop a more nuanced understanding of how people with Alzheimer's disease (AD) and their families are affected by the disease and how they respond to the challenges AD poses. Research Design and Methods: Using constructivist grounded theory, the study explored the experiences of living with AD for native Spanish families residing in Navarra...
June 15, 2017: Gerontologist
https://www.readbyqxmd.com/read/28630765/enhanced-depth-imaging-optical-coherence-tomography-a-new-way-measuring-choroidal-thickness-in-pregnant-women
#6
REVIEW
Jun Zhang, Huiyun Wang, Qiubo Yu, Qihu Tong, Qinkang Lu
The body changes markedly during pregnancy; each system behaves differently from a nonpregnant state. As the eyes are the only windows to see directly what is going on in the internal environment, more and more researches have been done to explain the association between ocular changes and the physiological and pathological changes during pregnancy. The choroid is one of the critical parts of the eye, providing nutrition. And abnormal choroid may result in ocular dysfunction and visual problems. As the optical coherence tomography develops, a rapid, direct, noninvasive, and nontoxic way is available to obtain the choroid situation of pregnant women, which may explain the mechanism of pregnancy-related eye diseases...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28629474/q-a-expansion-microscopy
#7
Ruixuan Gao, Shoh M Asano, Edward S Boyden
Expansion microscopy (ExM) is a recently invented technology that uses swellable charged polymers, synthesized densely and with appropriate topology throughout a preserved biological specimen, to physically magnify the specimen 100-fold in volume, or more, in an isotropic fashion. ExM enables nanoscale resolution imaging of preserved samples on inexpensive, fast, conventional microscopes. How does ExM work? How good is its performance? How do you get going on using it? In this Q&A, we provide the answers to these and other questions about this new and rapidly spreading toolbox...
June 19, 2017: BMC Biology
https://www.readbyqxmd.com/read/28628385/serious-games-for-psychotherapy-a-systematic-review
#8
Christiane Eichenberg, Markus Schott
INTRODUCTION: In the evolving digital age, media applications are increasingly playing a greater role in the field of psychotherapy. While the Internet is already in the phase of being established when it comes to the care of mental disorders, experimentation is going on with other modern media such as serious games. A serious game is a game in which education and behavior change is the goal, alongside with entertainment. OBJECTIVE: The objective of the present article was to provide a first empirical overview of serious games applied to psychotherapy and psychosomatic rehabilitation...
June 2017: Games for Health
https://www.readbyqxmd.com/read/28618123/-pain-relieved-but-still-struggling-critically-ill-patients-experiences-of-pain-and-other-discomforts-during-analgosedation
#9
Helene Berntzen, Ida Torunn Bjørk, Hilde Wøien
AIM & OBJECTIVE: To explore how critically ill patients treated according to a strategy of analgosedation experience and handle pain, other discomforts, and wakefulness. BACKGROUND: Patients experience both pain and discomfort while in the intensive care unit (ICU). International guidelines recommend focused pain treatment and light sedation. An analgosedation protocol favoring pain management, light sedation and early mobilization was implemented in our university hospital medical and surgical ICU in Norway in 2014...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28612605/spectrum-of-slow-and-super-slow-picosecond-to-nanosecond-water-dynamics-around-organic-and-biological-solutes
#10
Gopakumar Ramakrishnan, Mario González-Jiménez, Adrian J Lapthorn, Klaas Wynne
Water dynamics in the solvation shell of solutes plays a very important role in the interaction of biomolecules and in chemical reaction dynamics. However, a selective spectroscopic study of the solvation shell is difficult because of the interference of the solute dynamics. Here we report on the observation of heavily slowed down water dynamics in the solvation shell of different solutes by measuring the low-frequency spectrum of solvation water, free from the contribution of the solute. A slowdown factor of ∼50 is observed even for relatively low concentrations of the solute...
June 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28610237/a-review-of-the-taxonomy-and-osteology-of-the-i-rhombophryne-i-i-serratopalpebrosa-i-species-group-anura-microhylidae-from-madagascar-with-comments-on-the-value-of-volume-rendering-of-micro-ct-data-to-taxonomists
#11
Mark D Scherz, Oliver Hawlitschek, Franco Andreone, Andolalao Rakotoarison, Miguel Vences, Frank Glaw
Over the last three years, three new species of saw-browed diamond frogs (Rhombophryne serratopalpebrosa species group)-a clade of cophyline microhylid frogs native to northern and eastern Madagascar-have been described. We here review the taxonomy of these frogs based on a new multi-gene phylogeny of the group, which confirms its monophyly but is insufficiently resolved to clarify most intra-group relationships. We confirm Rhombophryne guentherpetersi (Guibé, 1974) to be a member of this group, and we re-describe it based on its type series and newly collected material; the species is characterised by small superciliary spines (overlooked in its original description), as well as large tibial glands and an unusually laterally compressed pectoral girdle...
June 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28604207/is-it-time-for-nurses-to-go-on-strike
#12
Emma Cowen
It is fair to say that nursing morale is low and public trust in the NHS is being chipped away. Every headline in the media seems to be about the problems faced by the NHS, with too few beds and nurses, and too little money.
June 12, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28602531/outcomes-of-hip-arthroplasty-after-failed-hip-arthroscopy-a-case-control-study
#13
Simon J M Parker, George Grammatopoulos, Owain L I Davies, Karen Lynch, Tom C B Pollard, Antonio J Andrade
BACKGROUND: Hip arthroscopy is increasingly being used in joint preservation surgery with clear benefits in the treatment of prearthritic conditions. A number of patients, however, will still go on to require subsequent hip arthroplasty, and at present, little evidence exists determining the impact that prior hip arthroscopy may have on the outcomes of a subsequent arthroplasty. METHODS: Using prospectively collated data, we identified 35 patients who had a hip arthroplasty (22 total hip arthroplasties and 13 hip resurfacing arthroplasties) after prior ipsilateral hip arthroscopy (cases)...
May 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28599741/implications-of-maple-syrup-urine-disease-in-newborns
#14
Pamela Harris-Haman, Lenora Brown, Susan Massey, Sivaranjani Ramamoorthy
Maple syrup urine disease (MSUD) is an inherited metabolic disorder that affects the body's ability to metabolize amino acids. If left untreated, it places newborns at risk for life-threatening health problems, including episodes of illness called metabolic crisis. Newborn screening for MSUD should ideally be done within the first 24 to 48 hours after birth. With proper screening, along with genetic counseling, nutritional counseling, primary care follow-up, and ongoing monitoring, newborns with MSUD can typically go on to live healthful lives...
June 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/28597869/the-qualitative-orientation-in-medical-education-research
#15
REVIEW
Jennifer Anne Cleland
Qualitative research is very important in educational research as it addresses the "how" and "why" research questions and enables deeper understanding of experiences, phenomena and context. Qualitative research allows you to ask questions that cannot be easily put into numbers to understand human experience. Getting at the everyday realities of some social phenomenon and studying important questions as they are really practiced helps extend knowledge and understanding. To do so, you need to understand the philosophical stance of qualitative research and work from this to develop the research question, study design, data collection methods and data analysis...
June 2017: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/28596071/genetic-and-metabolic-engineering-approaches-for-the-production-and-delivery-of-l-asparaginases-an-overview
#16
REVIEW
Jalaja Vidya, Syed Sajitha, Mrudula Vasudevan Ushasree, Raveendran Sindhu, Parameswaran Binod, Aravind Madhavan, Ashok Pandey
L-asparaginase is one of the protein drugs for countering leukemia and lymphoma. A major challenge in the therapeutic potential of the enzyme is its immunogenicity, low-plasma half-life and glutaminase activity that are found to be the reasons for toxicities attributed to asparaginase therapy. For addressing these challenges, several research and developmental activities are going on throughout the world for an effective drug delivery for treatment of cancer. Hence there is an urgent need for the development of asparaginase with improved properties for efficient drug delivery...
May 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28595673/neonatal-dna-methylation-and-early-onset-conduct-problems-a-genome-wide-prospective-study
#17
Charlotte A M Cecil, Esther Walton, Sara R Jaffee, Tom O'Connor, Barbara Maughan, Caroline L Relton, Rebecca G Smith, Wendy McArdle, Tom R Gaunt, Isabelle Ouellet-Morin, Edward D Barker
Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4-13 years), using data drawn from the Avon Longitudinal Study of Parents and Children...
June 9, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28592689/control-of-the-strength-of-visual-motor-transmission-as-the-mechanism-of-rapid-adaptation-of-priors-for-bayesian-inference-in-smooth-pursuit-eye-movements
#18
Timothy Darlington, Stefanie Tokiyama, Stephen G Lisberger
Bayesian inference provides a cogent account of how the brain combines sensory information with "priors" based on past experience to guide many behaviors, including smooth pursuit eye movements. We now demonstrate very rapid adaptation of the pursuit system's priors for target direction and speed. We go on to leverage that adaptation to outline possible neural mechanisms that could cause pursuit to show features consistent with Bayesian inference. Adaptation of the prior causes changes in the eye speed and direction at the initiation of pursuit...
June 7, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28589114/unexpected-findings-in-a-child-with-atypical-hemolytic-uremic-syndrome-an-example-of-how-genomics-is-changing-the-clinical-diagnostic-paradigm
#19
Eleanor G Seaby, Rodney D Gilbert, Gaia Andreoletti, Reuben J Pengelly, Catherine Mercer, David Hunt, Sarah Ennis
CBL is a tumor suppressor gene on chromosome 11 encoding a multivalent adaptor protein with E3 ubiquitin ligase activity. Germline CBL mutations are dominant. Pathogenic de novo mutations result in a phenotype that overlaps Noonan syndrome (1). Some patients with CBL mutations go on to develop juvenile myelomonocytic leukemia (JMML), an aggressive malignancy that usually necessitates bone marrow transplantation. Using whole exome sequencing methods, we identified a known mutation in CBL in a 4-year-old Caucasian boy with atypical hemolytic uremic syndrome, moyamoya phenomenon, and dysmorphology consistent with a mild Noonan-like phenotype...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28577311/acclimation-of-2-chlorophenol-biodegrading-activated-sludge-and-microbial-community-analysis
#20
(no author information available yet)
Taking glucose as co-substrate, the activated sludge which could effectively biodegrade 2-chlorophenol (2-CP) of 40 mg/L was successfully domesticated after acclimation for 49 days in sequencing batch reactors. High-throughput sequencing (HTS) analysis revealed that the community richness initially increased for 5 days and then decreased after another 20 days with the increase of 2-CP. The original sludge obtained from water resource recovery facility had the highest diversity. At the beginning of acclimation, the community diversity decreased...
June 2, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
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