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https://www.readbyqxmd.com/read/29458191/a-novel-neuropilin-1-binding-sequence-in-the-human-t-cell-lymphotropic-virus-type-1-envelope-glycoprotein
#1
Hideki Kusunoki, Toshiyuki Tanaka, Toshiyuki Kohno, Kazuhiko Matsuhashi, Kazuo Hosoda, Kaori Wakamatsu, Isao Hamaguchi
Entry of human T-cell lymphotropic virus type 1 (HTLV-1) into host cells is mainly mediated by interactions between the viral envelope glycoprotein surface unit (SU) and three host receptors: glucose transporter type 1, heparin/heparan sulfate proteoglycan, and neuropilin-1 (Nrp1). Here, we analyzed the interaction between HTLV-1 SU and Nrp1 using nuclear magnetic resonance and isothermal titration calorimetry. We found that two SU peptides, residues 85-94 and residues 304-312, bound directly to the Nrp1 b1 domain with affinities of 7...
February 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29458086/characterization-of-uniaxial-high-speed-stretch-as-an-in-vitro-model-of-mild-traumatic-brain-injury-on-the-blood-brain-barrier
#2
Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nasya M Sturdivant, Syed Z Imam, Sumit Sarkar, William Slikker, Merle G Paule, Kartik Balachandran, Syed F Ali
Traumatic brain injury (TBI) occurs when external mechanical forces induce brain damage as result of impact, penetration or rapid acceleration/deceleration that causes deformation of brain tissue. Depending on its severity, TBI can be classified as mild, moderate or severe and can lead to blood-brain barrier (BBB) dysfunction. In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the BBB...
February 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29458046/bmp-2-induces-angiogenesis-by-provoking-integrin-%C3%AE-6-expression-in-human-endothelial-progenitor-cells
#3
Wei-Cheng Chen, Ching-Hu Chung, Yung-Chang Lu, Min-Huan Wu, Po-Hsun Chou, Juei-Yu Yen, Yu-Wei Lai, Guo-Shou Wang, Shih-Chia Liu, Jen-Kun Cheng, Yih-Jer Wu, Hung-I Yeh, Li-Yu Wang, Shih-Wei Wang
Bone morphogenetic proteins-2 (BMP-2) is a multifunctional cytokine, capable of governing several cellular functions, including proliferation, motility, differentiation, and angiogenesis. Circulating endothelial progenitor cells (EPCs) have been shown to facilitate tissue repair, postnatal neovascularization, and tumor associated angiogenesis. Nevertheless, the impact of BMP-2 on angiogenesis of human EPCs has largely remained a mystery. In this study, we found that BMP-2 promoted cell migration and tube formation of EPCs in a concentration-dependent manner, indicating BMP-2 induced in vitro angiogenesis in human EPCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29458045/aldose-reductase-inhibitor-fidarestat-prevents-doxorubicin-induced-endothelial-cell-death-and-dysfunction
#4
Himangshu Sonowal, Pabitra Pal, Kirtikar Shukla, Ashish Saxena, Satish K Srivastava, Kota V Ramana
Despite doxorubicin (Dox) being one of the most widely used chemotherapy agents for breast, blood and lung cancers, its use in colon cancer is limited due to increased drug resistance and severe cardiotoxic side effects that increase mortality associated with its use at high doses. Therefore, better adjuvant therapies are warranted to improve the chemotherapeutic efficacy and to decrease cardiotoxicity. We have recently shown that aldose reductase inhibitor, fidarestat, increases the Dox-induced colon cancer cell death and reduces cardiomyopathy...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29457843/the-tumour-stroma-ratio-in-colon-cancer-the-biological-role-and-its-prognostic-impact
#5
REVIEW
Gabi W van Pelt, Tessa P Sandberg, Hans Morreau, Hans Gelderblom, J Han J M van Krieken, Rob A E M Tollenaar, Wilma E Mesker
The tumour microenvironment consists of a complex mixture of non-neoplastic cells including fibroblasts, immune cells and endothelial cells embedded in the proteins of the extracellular matrix. The tumour microenvironment plays an active role in tumour behaviour. By interacting with cancer cells, it influences disease progression and the metastatic capacity of the tumour. Tumours with a high amount of stroma correspond to poor patient prognosis. The tumour-stroma ratio (TSR) is a strong independent prognostic tool in colon cancer and provides additional value to the current clinically used TNM classification...
February 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29457790/cd163-macrophages-promote-angiogenesis-and-vascular-permeability-accompanied-by-inflammation-in-atherosclerosis
#6
Liang Guo, Hirokuni Akahori, Emanuel Harari, Samantha L Smith, Rohini Polavarapu, Vinit Karmali, Fumiyuki Otsuka, Rachel L Gannon, Ryan E Braumann, Megan H Dickinson, Anuj Gupta, Audrey L Jenkins, Michael J Lipinski, Johoon Kim, Peter Chhour, Paul S de Vries, Hiroyuki Jinnouchi, Robert Kutys, Hiroyoshi Mori, Matthew D Kutyna, Sho Torii, Atsushi Sakamoto, Cheol Ung Choi, Qi Cheng, Megan L Grove, Mariem A Sawan, Yin Zhang, Yihai Cao, Frank D Kolodgie, David P Cormode, Dan E Arking, Eric Boerwinkle, Alanna C Morrison, Jeanette Erdmann, Nona Sotoodehnia, Renu Virmani, Aloke V Finn
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression...
February 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#7
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456688/overexpression-of-microrna-506-3p-aggravates-the-injury-of-vascular-endothelial-cells-in-patients-with-hypertension-by-downregulating-beclin1-expression
#8
Fanfan Yi, Yugui Hao, Xiaoyi Chong, Wei Zhong
The aim of the present study was to measure the expression of microRNA (miRNA)-506-3p in the peripheral blood of patients with hypertension and to determine the biological functions and mechanisms of action of miR-506-3p. A total of 61 patients with primary hypertension were included in the present study. Peripheral blood was collected from all patients, as well as 31 healthy subjects who were included in a control group. The expression of miR-506-3p in peripheral blood was determined by reverse transcription-quantitative polymerase chain reaction...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456679/mir-98-inhibits-cell-proliferation-and-induces-cell-apoptosis-by-targeting-mapk6-in-huvecs
#9
Chuanxian Hu, Su Huang, Fafu Wu, Hui Ding
The aim of current study was to explore the role of microRNA (miR)-98 in atherosclerosis. Human vascular endothelial cells (HVECs) were isolated from the peripheral blood of healthy volunteers and patients with atherosclerosis. Compared with endothelial cells from the healthy control group, the expression level of mitogen activated protein kinase (MAPK)6 was significantly upregulated and miR-98 was downregulated in the endothelial cells of patients with atherosclerosis. The human umbilical vein endothelial cell line (HUVEC) was adopted to perform in vitro studies...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456663/high-expression-of-sdf-1-and-vegf-is-associated-with-poor-prognosis-in-patients-with-synovial-sarcomas
#10
Qi Feng, Peng Guo, Jin Wang, Xiaoyu Zhang, Hui-Chai Yang, Jian-Gang Feng
Stromal cell-derived factor-1 (SDF-1) predicts poor clinical outcomes of certain types of cancer. Furthermore, vascular endothelial growth factor (VEGF) promotes the growth and metastasis of solid tumors. The aim of the present study was to examine the expression of SDF-1 and VEGF in patients with synovial sarcoma and to determine their expression is correlated with unfavorable outcomes. Levels of SDF-1 and VEGF proteins were evaluated in 54 patients with synovial sarcoma using immunohistochemical and immunofluorescence staining...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456642/anti-semaphorin-7a-single-chain-antibody-demonstrates-beneficial-effects-on-pulmonary-inflammation-during-acute-lung-injury
#11
Xiao Chen, Hailing Wang, Kui Jia, Hao Wang, Tao Ren
Pulmonary inflammation is a primary characteristic of lung injury initiated by the accession of immune cells into the alveolar space. Neutrophil migration serves an important role in pulmonary inflammation mediated by the migration of neutrophils into hypoxic tissue sites. The elimination of pulmonary inflammation is directly associated with rehabilitation in patients with lung injury. Anti-inflammatory treatment is essential following lung injury and ultimately determines patient outcomes. Semaphorin-7A (SEMA-7A) is a member of the Semaphorin family that influences the migration of neutrophils into hypoxic tissue sites, thus promoting inflammation...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456630/roles-of-eph-ephrin-bidirectional-signaling-in-central-nervous-system-injury-and-recovery
#12
Jin-Shan Yang, Hui-Xing Wei, Ping-Ping Chen, Gang Wu
Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS injury. However, this approach has largely failed to reduce CNS damage or improve the functional recovery of patients. Erythropoietin-producing human hepatocellular (Eph) receptors and ephrin ligands have attracted considerable attention since their discovery, due to their extensive distribution and unique bidirectional signaling between astrocytes and neurons...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456539/generation-of-human-immunosuppressive-myeloid-cell-populations-in-human-interleukin-6-transgenic-nog-mice
#13
Asami Hanazawa, Ryoji Ito, Ikumi Katano, Kenji Kawai, Motohito Goto, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cells are considered a key target of cancer immune therapy, in vivo animal models allowing differentiation of human immunosuppressive myeloid cells have yet to be established, hampering the development of novel cancer therapies. In this study, we established a novel humanized transgenic (Tg) mouse strain, human interleukin (hIL)-6-expressing NOG mice (NOG-hIL-6 transgenic mice)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456507/the-effects-of-vitamin-d-supplementation-on-signaling-pathway-of-inflammation-and-oxidative-stress-in-diabetic-hemodialysis-a-randomized-double-blind-placebo-controlled-trial
#14
Hamed Haddad Kashani, Elahe Seyed Hosseini, Hossein Nikzad, Alireza Soleimani, Maryam Soleimani, Mohammad Reza Tamadon, Fariba Keneshlou, Zatollah Asemi
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU ( n = 30) or placebo ( n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29456178/hoxb4-promotes-hemogenic-endothelium-formation-without-perturbing-endothelial-cell-development
#15
Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A Horn, Stefan Heinrichs, Hannes Klump
Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes hematopoietic development, in vitro, is not yet known. However, its identification is a prerequisite to unambiguously identify the molecular circuits controlling hematopoiesis, since the activity of HOX proteins is highly cell and context dependent...
February 15, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29456135/pericyte-alk5-timp3-axis-contributes-to-endothelial-morphogenesis-in-the-developing-brain
#16
Jui M Dave, Teodelinda Mirabella, Scott D Weatherbee, Daniel M Greif
The murine embryonic blood-brain barrier (BBB) consists of endothelial cells (ECs), pericytes (PCs), and basement membrane. Although PCs are critical for inducing vascular stability, signaling pathways in PCs that regulate EC morphogenesis during BBB development remain unexplored. Herein, we find that murine embryos lacking the transforming growth factor β (TGF-β) receptor activin receptor-like kinase 5 (Alk5) in brain PCs (mutants) develop gross germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH)...
February 8, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29456110/synthesis-spectroscopic-studies-and-biological-evaluation-of-acridine-derivatives-the-role-of-aggregation-on-the-photodynamic-efficiency
#17
Carles Felip-León, Olga Martínez-Arroyo, Santiago Díaz-Oltra, Juan F Miravet, Nadezda Apostolova, Francisco Galindo
Two new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized compounds show very different self-aggregating properties since only 1 present a strong tendency to aggregate in water. Biological assays were conducted with two cell types: hepatoma cells (Hep3B) and human umbilical vein endothelial cells (HUVEC). Photodynamic therapy (PDT) studies carried out with Hep3B cells showed that non-aggregating compound 2 showed photoxicity, ascribed to the production of singlet oxygen, being aggregating compound 1 photochemically inactive...
February 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29456054/the-relationship-between-serum-interleukin-1%C3%AE-and-asymptomatic-infrarenal-abdominal-aortic-aneurysm-size-morphology-and-growth-rates
#18
Mehtab Ahmad, Sahithi Kuravi, James Hodson, G Ed Rainger, Gerard B Nash, Rajiv K Vohra, Andrew W Bradbury
OBJECTIVE/BACKGROUND: In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates. METHODS: Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates...
February 16, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29455365/gender-differences-in-glycemic-control-and-diabetes-related-factors-in-young-adults-with-type-1-diabetes-results-from-the-metro-study
#19
Maria Ida Maiorino, Giuseppe Bellastella, Ofelia Casciano, Michela Petrizzo, Maurizio Gicchino, Mariangela Caputo, Annalisa Sarnataro, Dario Giugliano, Katherine Esposito
PURPOSE: To describe gender differences concerning glycemic control, cardiovascular risk factors, diabetic complications, concomitant pathologies, and circulating endothelial progenitor cells (EPCs), in a population of young adults with type 1 diabetes. METHODS: We collected data from 300 consecutively patients (168 males and 132 females), aged 18-30 years, among those admitted at Diabetes Unit of University of Campania "Luigi Vanvitelli" (Naples, Italy) from March 2012 to January 2017...
February 17, 2018: Endocrine
https://www.readbyqxmd.com/read/29455108/ureaplasma-isolates-differentially-modulate-growth-factors-and-cell-adhesion-molecules-in-human-neonatal-and-adult-monocytes
#20
Kirsten Glaser, Christine Silwedel, Ana Maria Waaga-Gasser, Birgit Henrich, Markus Fehrholz, Heike Claus, Christian P Speer
Generally regarded as commensal bacteria, the pathogenicity of Ureaplasma has often been considered low. Controversy remains concerning the clinical relevance of Ureaplasma infection in the pathogenesis of inflammation-related morbidities. Recently, we demonstrated Ureaplasma-driven pro-inflammatory cytokine responses in human monocytes in vitro. We hypothesized that Ureaplasma may induce further inflammatory mediators. Using qRT-PCR and multi-analyte immunoassay, we assessed the expression of granulocyte-colony stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in term neonatal and adult monocytes exposed to Ureaplasma urealyticum serovar 8 (Uu8) and U...
February 15, 2018: Cytokine
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