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Dan-na Shen, Xu-fu Yi, Xiao-gang Chen, Tong-li Xu, Li-juan Cui
Individual response to drugs, toxicants, environmental chemicals and allergens varies with genotype. Some respond well to these substances without significant consequences, while others may respond strongly with severe consequences and even death. Toxicogenetics and toxicogenomics as well as pharmacogenetics explain the genetic basis for the variations of individual response to toxicants by sequencing the human genome and large-scale identification of genome polymorphism. The new disciplines will provide a new route for forensic specialists to determine the cause of death...
October 2007: Fa Yi Xue za Zhi
R Culverhouse
BACKGROUND/AIMS: Many diseases important to public health are not due solely to a single mutation or environmental insult. Instead, complex interactions among multiple genes and environmental exposures likely play crucial roles in the etiology of diverse phenotypes from schizophrenia to chemotherapy response. The Restricted Partition Method (RPM) was designed to detect qualitative genetic and environmental factors contributing to a quantitative trait, even if the contribution is predominantly presented as an interaction (displaying little or no signal in univariate analyses)...
2007: Human Heredity
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