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JOURNAL ARTICLE
Rishi Sharma, Abigail Chischolm, Meet Parikh, Mahesh Thakkar
BACKGROUND: Binge drinking, characterized by heavy episodic alcohol consumption, poses significant health hazards and increases the likelihood of developing an alcohol use disorder (AUD). Given the growing prevalence of this behavior and its negative consequences, there is a need to explore novel therapeutic targets. Accumulating evidence suggests that cholinergic interneurons (CIN) within the shell region of the nucleus accumbens (NAcSh) play a critical role in reward and addiction. However, their specific involvement in binge alcohol administration remains unclear...
March 29, 2024: Alcohol Clin Exp Res (Hoboken)
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JOURNAL ARTICLE
Azoukalné Moukénet, Kebfene Moudiné, Ngarkodje Ngarasta, Clement Kerah Hinzoumbe, Ibrahima Seck
BACKGROUND: In Chad, malaria remains a significant public health concern, particularly among nomadic populations. Geographical factors and the mobility of human populations have shown to be associated with the diversity of Plasmodium species. The study aims to describe the malaria prevalence among nomadic children and to investigate its associated factors. METHODS: A cross-sectional study was conducted in February and October 2021 among nomadic communities in Chad...
March 28, 2024: BMC Public Health
#23
JOURNAL ARTICLE
Latif Adams, Dorcas Obiri-Yeboah, Michael Afiadenyo, Sherif Hamidu, Abigail Aning, Ebenezer Ehun, Katie Shiels, Akanksha Joshi, Maxwell Mamfe Sakyimah, Kwadwo Asamoah Kusi, Irene Ayi, Michelle Mckeon Bennett, Siobhan Moane
African Trypanosomiasis caused by trypanosome parasites continues to be a major neglected health problem, particularly in developing countries. Current treatments are marked by serious side effects, low effectiveness, high toxicity, and drug resistance prompting the need to develop novel, safe, effective, and alternative antitrypanosomal compounds. Anopyxis klaineana is an ethnomedicinal plant used in West Africa to treat many ailments including protozoan diseases. In this study, we investigated the antitrypanosomal potential of stem bark extracts of A...
March 30, 2024: Heliyon
#24
JOURNAL ARTICLE
Kerui Zhang, Chenchen Wei, Yaqing Shao, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Yuan Li, Zhongshan Gou
BACKGROUND: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable indicator for assessing the risk of cardiovascular disease. However, the ability of non-HDL-C/apoB ratio to predict the risk of long-term mortality among the general population remains uncertain. The aim of this study is to explore the association of non-HDL-C/apoB ratio with long-term all-cause and cardiovascular mortality in adults of the United States...
March 30, 2024: Heliyon
#25
JOURNAL ARTICLE
Ahmed Al-Imam, Marek A Motyka, Michal Michalak
Psychedelics can profoundly alter cognition and consciousness. Their use in Middle Eastern countries, including Iraq, is ambiguous. We aim to investigate psychedelic awareness and use among Iraqi and Polish medical students. We surveyed 739 university students from Poland (315) and Iraq (424) using 31 adapted questions from the European School Survey Project on Alcohol and Other Drugs (ESPAD). We conducted multivariable analyses based on binary logistic regression to identify the factors associated with psychedelic awareness and use...
March 5, 2024: European journal of investigation in health, psychology and education
#26
JOURNAL ARTICLE
Bianca Da Costa Dias, Windy Sekgele, Duduzile Nhlapo, Mahlape P Mahlangu, Johanna M E Venter, Dumisile V Maseko, Etienne E Müller, Maurice Greeves, Paul Botha, Frans Radebe, Tendesayi Kufa, Ranmini S Kularatne
BACKGROUND: In South Africa, extragenital etiological sexually transmitted infection (STI) screening among men who have sex with men (MSM) is not routinely available. We aimed to determine the prevalence of STI pathogens at rectal and pharyngeal sites, syphilis seroprevalence, and associated risk factors among a selection of high-risk MSM without symptomatic urethritis attending a men's health clinic in Johannesburg, South Africa. METHODS: A cross-sectional study was conducted in 2022...
April 1, 2024: Sexually Transmitted Diseases
#27
JOURNAL ARTICLE
David T Zhu, Anthony Zhong, Winnie J Ho, Suzanne Tamang
Asian Americans have been historically underrepresented in the national drug overdose discourse due to their lower substance use and overdose rates compared to other racial/ethnic groups. However, aggregated analyses fail to capture the vast diversity among Asian-American subgroups, obscuring critical disparities. We conducted a cross-sectional study between 2018 and 2021 examining Asian-American individuals within the CDC WONDER database with drug overdoses as the underlying cause of death (n = 3195; ICD-10 codes X40-X44, X60-X64, X85, and Y10-Y14) or psychoactive substance-related mental and behavioral disorders as one of multiple causes of death (n = 15,513; ICD-10 codes F10-F19)...
March 26, 2024: Journal of Racial and Ethnic Health Disparities
#28
JOURNAL ARTICLE
Shilin Song, Yuanyuan Li, Lin Lv, Mengqi Dong, Zhanfen Qin
Tetrabromobisphenol A (TBBPA) is a widely used brominated flame retardant. There is evidence showing that TBBPA can exert thyroid disrupting effects in mammals, but different results were also reported, along with inconsistent reports regarding its neurotoxicity. Here, we investigated thyroid disrupting effects and neurotoxicity of TBBPA (5, 50, 500 µg/(kg·day)) to male mice following maternal and direct exposure through drinking water, with the anti-thyroid drug propylthiouracil (PTU) as the positive control...
August 2024: Journal of Environmental Sciences (China)
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JOURNAL ARTICLE
Bow Suprasert, Moranda Tate, Danyion Reagan, Raul Ruiz, Katherine Gao, Katherine McNaughton, Kassandra Miller, Alexander Marr, Kelly D Taylor, Erin C Wilson, Willi McFarland
Clinical trials provide evidence that pre-exposure prophylaxis (PrEP) prevents HIV acquisition including through sharing of injection equipment among people who inject drugs (PWID). However, uptake among many populations at risk for HIV has been slow, particularly among PWID. We examined data from the National HIV Behavioral Surveillance (NHBS) from San Francisco in 2022 to measure PrEP uptake and identify factors associated with PrEP awareness among PWID. Of 479 PWID with HIV-negative or unknown HIV status, 54...
March 25, 2024: AIDS and Behavior
#30
JOURNAL ARTICLE
Lisham Ashrafioun, Nicholas P Allan, Tracy A Stecker
BACKGROUND: The purpose of this study was to report on feasibility, acceptability, and initial efficacy data cognitive-behavioral therapy for perceived isolation (CBT-PSI) compared to health education among individuals with opioid use disorders (OUD) reporting elevated loneliness. METHODS: Participants (n = 125) with OUD reporting elevated loneliness were recruited using online advertising to participate in a telehealth-delivered randomized clinical trial. Participants received either a 6-session CBT-PSI (n = 63) or health education (n = 62)...
March 15, 2024: Drug and Alcohol Dependence
#31
JOURNAL ARTICLE
Cynthia Semá Baltazar, Rachid Muleia, Auria Ribeiro Banze, Makini Boothe
BACKGROUND: Hazardous drinking and drug consumption are associated with an increased risk of HIV due to the complex interplay of factors influencing decision-making capability, stigma and social marginalization. In this study, we explore the patterns of hazardous alcohol and drug use and correlates of risk factors among female sex workers (FSW) and men who as sex with men (MSM) in Mozambique. METHODS: We conducted a secondary data analysis of bio-behavioral surveys (BBS) among FSW and MSM using a respondent-driven sampling methodology conducted in five main urban areas of Mozambique from 2019 to 20...
March 21, 2024: BMC Public Health
#32
JOURNAL ARTICLE
Lisi Yan, Jin Chen, Lingling Xie, Tianyi Li, Yue Hu, Siqi Hong, Li Jiang
BACKGROUND: Although sleep quality (SQ) reportedly affects the health-related quality of life (QOL) of patients with epilepsy, little is known about the potential association between SQ and QOL, particularly in children with epilepsy (CWE). Our study aimed to investigate the mediating effect of SQ on the QOL of CWE to obtain more information for the prevention and treatment of epilepsy in children. METHODS: We collected general demographic and clinical data of 212 CWE and 79 controls (children who visited the Health Examination Department), and their guardians were instructed to answer the Children's Sleep Habits Questionnaire (CSHQ) and the optimized Quality of Life in Childhood Epilepsy Questionnaire-16 (QOLCE-16)...
March 20, 2024: Epilepsy & Behavior: E&B
#33
JOURNAL ARTICLE
Huseyin Bayazit, Regina Baronia, Sarah M Wakefield
INTRODUCTION: This study investigates the association between Methamphetamine (MA) intoxication and suicidal ideation/behavior in patients presenting to emergency departments. Amidst rising MA use and co-use with opioids, this "twin epidemic" has manifested in increasing admissions for MA intoxication, often accompanied by psychiatric symptoms that can escalate to suicidal behaviors. METHOD: This retrospective study utilized patient records and analyzed data from 629 patients admitted to a Texas emergency department in 2020, with MA intoxication confirmed via urine tests and patient interviews...
March 21, 2024: Current Medical Research and Opinion
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JOURNAL ARTICLE
Hong-Li Guo, Dan-Dan Wu, Di Fu, Yue Li, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Wei-Rong Fang, Jing Xu, Ya-Hui Hu, Qian-Qi Liu, Feng Chen
Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to investigate the link between the efficacy and tolerability of atomoxetine in children with ADHD and plasma atomoxetine concentrations based on their CYP2D6 genotypes; (2) to offer TDM reference range recommendations for atomoxetine based on the CYP2D6 genotypes of children receiving different dosage regimens...
March 19, 2024: Translational Psychiatry
#35
JOURNAL ARTICLE
Robert Ws Coulter, Isabella Kaur Mahal, Clarisse A Lin, Shari Kessel Schneider, Aaryn S Mathias, Karuna Baral, Elizabeth Miller, Kaleab Z Abebe
BACKGROUND: Sexual and gender minority youths (lesbian, gay, bisexual, transgender, nonbinary, and queer individuals) face elevated risks of substance use (eg, alcohol and tobacco) and mental health issues (eg, depressive symptoms and suicidality) compared to their cisgender heterosexual peers. These inequities are hypothesized to be reduced by building supportive high school environments via the training of school staff. An intervention that trains school staff to better understand and support sexual and gender minority youths and engage in positive bystander behaviors that protect them from bullying exposure may reduce disparities in drug and alcohol use among them...
March 19, 2024: JMIR Research Protocols
#36
JOURNAL ARTICLE
Ricardo Abrantes, Victor Pimentel, Mafalda N S Miranda, Ana Rita Silva, António Diniz, Bianca Ascenção, Carmela Piñeiro, Carmo Koch, Catarina Rodrigues, Cátia Caldas, Célia Morais, Domitília Faria, Elisabete Gomes da Silva, Eugénio Teófilo, Fátima Monteiro, Fausto Roxo, Fernando Maltez, Fernando Rodrigues, Guilhermina Gaião, Helena Ramos, Inês Costa, Isabel Germano, Joana Simões, Joaquim Oliveira, José Ferreira, José Poças, José Saraiva da Cunha, Jorge Soares, Sandra Fernandes, Kamal Mansinho, Liliana Pedro, Maria João Aleixo, Maria João Gonçalves, Maria José Manata, Margarida Mouro, Margarida Serrado, Micaela Caixeiro, Nuno Marques, Olga Costa, Patrícia Pacheco, Paula Proença, Paulo Rodrigues, Raquel Pinho, Raquel Tavares, Ricardo Correia de Abreu, Rita Côrte-Real, Rosário Serrão, Rui Sarmento E Castro, Sofia Nunes, Telo Faria, Teresa Baptista, Daniel Simões, Luis Mendão, M Rosário O Martins, Perpétua Gomes, Marta Pingarilho, Ana B Abecasis
INTRODUCTION: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. METHODS: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral questionnaires and the viral genomic sequence obtained in the drug resistance test before starting antiretrovirals (ARVs)...
2024: Frontiers in Public Health
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JOURNAL ARTICLE
Cinzia Zatti, Andrea Pilotto, Clint Hansen, Andrea Rizzardi, Marcello Catania, Robbin Romijnders, Leandro Purin, Maria P Pasolini, Eva Schaeffer, Andrea Galbiati, Luigi Ferini-Strambi, Daniela Berg, Walter Maetzler, Alessandro Padovani
Idiopathic REM sleep Behavior Disorder (iRBD) is a condition at high risk of developing Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study was to evaluate subtle turning alterations by using Mobile health technology in iRBD individuals without subthreshold parkinsonism. A total of 148 participants (23 persons with polysomnography-confirmed iRBD without subthreshold parkinsonism, 60 drug-naïve PD patients, and 65 age-matched controls were included in this prospective cross-sectional study...
March 18, 2024: NPJ Parkinson's Disease
#38
JOURNAL ARTICLE
M Cifre-Herrando, G Roselló-Márquez, J García-Antón
Endocrine disruptors chemicals (EDCs) pose significant health risks, including cancer, behavioral disorders, and infertility. In this study, we employed the photoelectrocatalysis (PEC) technique with optimized tungsten oxide (WO3 ) nanostructures as a photoanode to degrade three diverse EDCs: methiocarb, dimethyl phthalate, and 4-tert-butylphenol. PEC degradation tests were carried out for individual contaminants and a mixture of them, assessing efficiency across different EDC families. Ultra High-Performance Liquid Chromatography and Mass Spectrometry was used to control the course of the experiments...
March 16, 2024: Environmental Toxicology and Pharmacology
#39
JOURNAL ARTICLE
Amirah Hani Ramli, Puspanjali Swain, Muhammad Syafiq Akmal Mohd Fahmi, Faridah Abas, Sze Wei Leong, Bimo Ario Tejo, Khozirah Shaari, Amatul Hamizah Ali, Hani Kartini Agustar, Rusdam Awang, Yee Ling Ng, Yee Ling Lau, Mohammad Aidiel Md Razali, Siti Nurulhuda Mastuki, Norazlan Mohmad Misnan, Siti Munirah Mohd Faudzi, Cheol-Hee Kim
Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for new effective antimalarial agents. Here we report on a virtual screening of ∼300 diarylpentanoids and derivatives, in search of potential Plasmodium falciparum lactate dehydrogenase ( Pf LDH) inhibitors with acceptable drug-like properties. Several molecules with binding affinities comparable to CQ were chosen for in vitro validation of antimalarial efficacy...
March 15, 2024: Heliyon
#40
JOURNAL ARTICLE
Olívia Garbin Koller, Vanessa Machado Menezes, Aline Busanello, Jussara Carnevale de Almeida
PURPOSE: To evaluate the association between intuitive eating and health outcomes in patients with type 2 diabetes in a cross-sectional study. METHODS: Consecutively, outpatients attending at university hospital underwent clinical, laboratory, lifestyle, and eating behavior evaluations. Intuitive eating was assessed using the Intuitive Eating Scale-2 (IES-2), and the Three Factor Eating Questionnaire-21 was adopted as a confirmatory tool for disordered eating behavior...
March 16, 2024: European Journal of Nutrition
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