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https://www.readbyqxmd.com/read/28742408/risk-competence-in-dealing-with-alcohol-and-other-drugs-in-adolescence
#1
Ede Nagy, Rolf Verres, Dennis Grevenstein
BACKGROUND: Adolescence is a critical phase for the development substance use patterns. We propose that individual competence in dealing with psychoactive substances is crucial for the development of healthy substance use behavior and prevention of substance misuse or addiction. OBJECTIVES: We present a new concept of health related skills in dealing with alcohol and other drugs in adolescence, its operationalization and validation. Our conception of risk competence (RICO) consists of the four major factors being Reflective, Informed, Self-Controlled and Life-Oriented, and their sub-facets...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28738861/the-risk-of-hiv-transmission-at-each-step-of-the-hiv-care-continuum-among-people-who-inject-drugs-a-modeling-study
#2
Daniel J Escudero, Mark N Lurie, Kenneth H Mayer, Maximilian King, Sandro Galea, Samuel R Friedman, Brandon D L Marshall
BACKGROUND: People who inject drugs (PWID) are at continued risk for HIV in the U.S., and experience disparities across the HIV care continuum compared to other high-risk groups. Estimates of the risk of HIV transmission at each stage of the care continuum may assist in identifying public health priorities for averting incident infections among PWID, in addition to transmissions to sexual partners of PWID. METHODS: We created an agent-based model simulating HIV transmission and the HIV care continuum for PWID in New York City (NYC) in 2012...
July 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28734107/extended-release-naltrexone-for-methamphetamine-dependence-among-men-who-have-sex-with-men-a-randomized-placebo-controlled-trial
#3
Phillip O Coffin, Glenn-Milo Santos, Jaclyn Hern, Eric Vittinghoff, Deirdre Santos, Tim Matheson, Grant Colfax, Steven L Batki
BACKGROUND AND AIMS: Methamphetamine use is increasingly prevalent and associated with HIV transmission. Early phase human studies suggested naltrexone reduced amphetamine use among dependent individuals. We tested if extended-release naltrexone (XRNTX) reduces methamphetamine use and associated sexual risk behaviors among high-risk methamphetamine-dependent men who have sex with men (MSM). DESIGN: Double-blind, placebo-controlled, randomized trial of XRTNX versus placebo over 12 weeks from 2012-2015...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28729837/optimization-and-in-vivo-profiling-of-a-refined-rat-model-of-walker-256-breast-cancer-cell-induced-bone-pain-using-behavioral-radiological-histological-immunohistochemical-and-pharmacological-methods
#4
Priyank Shenoy, Andy Kuo, Irina Vetter, Maree T Smith
In the majority of patients with advanced breast cancer, there is metastatic spread to bones resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced bone pain (BCIBP) often produce inadequate pain relief due to dose-limiting side-effects. A major impediment to the discovery of novel well-tolerated analgesic agents for the relief of pain due to bony metastases is the fact that most cancer-induced bone pain models in rodents relied on the systemic injection of cancer cells, causing widespread formation of cancer metastases and poor general animal health...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28725261/health-risk-behavior-among-chronically-ill-adolescents-a-systematic-review-of-assessment-tools
#5
REVIEW
Derrick Ssewanyana, Moses Kachama Nyongesa, Anneloes van Baar, Charles R Newton, Amina Abubakar
BACKGROUND: Adolescents living with chronic illnesses engage in health risk behaviors (HRB) which pose challenges for optimizing care and management of their ill health. Frequent monitoring of HRB is recommended, however little is known about which are the most useful tools to detect HRB among chronically ill adolescents. AIMS: This systematic review was conducted to address important knowledge gaps on the assessment of HRB among chronically ill adolescents. Its specific aims were to: identify HRB assessment tools, the geographical location of the studies, their means of administration, the psychometric properties of the tools and the commonest forms of HRB assessed among adolescents living with chronic illnesses globally...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28718490/barriers-to-hiv-testing-linkage-to-care-and-treatment-adherence-a-cross-sectional-study-from-a-large-urban-center-of-brazil
#6
Sarah MacCarthy, Michael Hoffmann, Amy Nunn, Luís Augusto Vasconcelos da Silva, Ines Dourado
Objective: Early, continued engagement with the HIV treatment continuum can help achieve viral suppression, though few studies have explored how risk factors for delays differ across the continuum. The objective of this study was to identify predictors of delayed diagnosis, delayed linkage to care, and nonadherence to treatment in the city of Salvador, Bahia, Brazil. Methods: Data were collected during 2010 in a cross-sectional study with a sample (n = 1 970) of HIV-infected individuals enrolled in care...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28713277/does-the-strategy-of-risk-group-testing-for-hepatitis-c-hit-the-target
#7
Mirjana R Jovanovic, Aleksandar Miljatovic, Laslo Puskas, Slobodan Kapor, Dijana L Puskas
In the European Union, it is estimated that there are 5.5 million individuals with chronic infection of hepatitis C. Intravenous drug abuse is undoubtedly the key source of the hepatitis C epidemic in Europe and the most efficient mode of transmission of HCV infections (primarily due to short incubation time, but also because the virus is introduced directly into the blood stream with the infected needle). Potentially high-risk and vulnerable populations in Europe (and the world) include immigrants, prisoners, sex workers, men having sex with men, individuals infected with HIV, psychoactive substance users etc...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28709437/profile-and-predictors-of-health-related-quality-of-life-among-type-ii-diabetes-mellitus-patients-in-quetta-city-pakistan
#8
Qaiser Iqbal, Noman Ul Haq, Sajid Bashir, Mohammad Bashaar
BACKGROUND: This study aims to assess the profile and predictors of Health-Related Quality of Life (HRQoL) in Type II Diabetes Mellitus (T2DM) patients in Quetta, Pakistan. METHODS: The study was designed as a questionnaire based, cross sectional analysis. 300 Type II diabetic patients attending public and private hospitals were targeted for data collection. In addition to demographic and disease related information, Euroqol Quality of Life was used to measure HRQoL...
July 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28705652/measuring-resilience-in-the-adolescent-population-a-succinct-tool-for-outpatient-adolescent-health
#9
Jordan Barger, Patty Vitale, John P Gaughan, Lori Feldman-Winter
OBJECTIVE: To create a valid tool to measure adolescent resilience, and to determine if this tool correlates with current participation in risk behaviors and prior adverse childhood events. STUDY DESIGN: One hundred adolescents were recruited from primary care clinics in New Jersey for this cross-sectional study. A "7Cs tool" was developed to measure resilience using the 7Cs model of resilience. All participants completed the 7Cs tool, the Adverse Childhood Events Survey, and the Health Survey for Adolescents to identify current risk behaviors...
July 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28701254/characteristics-of-older-adults-who-consume-alcohol-while-on-antidepressants
#10
Erin Ulrich, Jacqueline Vonderhaar, Allison Tenhouse
OBJECTIVES: Determine the characteristics of older Americans who self-report consuming alcohol and taking at least one antidepressant. DESIGN: This study utilized cross-sectional analyses. SETTING: The University of Michigan Health and Retirement Study and its subsurvey Prescription Drug Study (PDS). PATIENTS, PARTICIPANTS: Those who reported taking at least one antidepressant prescription medication, were 65 years of age or older, and were enrolled in Medicare or Medicaid between 2002 and 2004...
July 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28654270/ultralong-hydroxyapatite-nanowires-based-paper-co-loaded-with-silver-nanoparticles-and-antibiotic-for-long-term-antibacterial-benefit
#11
Zhi-Chao Xiong, Zi-Yue Yang, Ying-Jie Zhu, Fei-Fei Chen, Yong-Gang Zhang, Ri-Long Yang
Hydroxyapatite is a kind of biocompatible, environmentally friendly, and versatile inorganic biomaterial. Herein, the preparation of ultralong hydroxyapatite nanowires (HAPNWs)-based antibacterial paper co-loaded with silver nanoparticles (AgNPs) and antibiotic is reported. HAPNWs are used to prepare AgNPs in situ using an aqueous solution containing AgNO3 under the sunlight without added reducing agent at room temperature. Subsequently, ciprofloxacin (CIP) as an antibiotic is loaded on the HAPNWs@AgNPs. The resultant HAPNWs@AgNPs-CIP paper possesses several unique properties, including high flexibility, high Brunauer-Emmett-Teller (BET) specific surface area (47...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653501/perceived-weight-discrimination-and-high-risk-health-related-behaviors
#12
Angelina R Sutin, Antonio Terracciano
OBJECTIVE: Perceived weight discrimination has been associated with several health-risk behaviors related to eating and physical activity. The purpose of this research is to test whether weight discrimination is associated with nonweight-related high-risk behaviors that put the individual's health at risk. METHODS: As part of a larger survey on health and well-being, participants (N = 5,163) reported on their experiences with weight discrimination and their engagement in four high-risk behaviors: current cigarette smoking, driving while intoxicated, risky sexual/drug use behaviors, and seat belt use...
July 2017: Obesity
https://www.readbyqxmd.com/read/28652072/evaluation-of-a-hepatitis-c-education-intervention-with-clients-enrolled-in-methadone-maintenance-and-needle-syringe-programs-in-malaysia
#13
Trena I Mukherjee, Veena Pillai, Siti Hafizah Ali, Frederick L Altice, Adeeba Kamarulzaman, Jeffrey A Wickersham
BACKGROUND: Approximately 40%-90% of people who inject drugs (PWID) in Malaysia have hepatitis C (HCV). PWID continue to be disproportionately affected by HCV due to their lack of knowledge, perceived risk and interest in HCV treatment. Education interventions may be an effective strategy for increasing HCV knowledge in PWID, and harm reduction services are uniquely positioned to implement and deploy such interventions. METHODS: We recruited 176 clients from methadone maintenance treatment (MMT: N=110) and needle/syringe programs (NSP: N=66) between November 2015 and August 2016...
June 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28648353/healthcare-contact-and-treatment-uptake-following-hepatitis-c-virus-screening-and-counseling-among-rural-appalachian-people-who-use-drugs
#14
Dustin B Stephens, April M Young, Jennifer R Havens
BACKGROUND: Hepatitis C virus (HCV) remains a major contributor to morbidity and mortality worldwide. Since 2009, Kentucky has led the United States in cases of acute HCV, driven largely by injection drug use in rural areas. Improved treatment regimens hold promise of mitigating the impact and transmission of HCV, but numerous barriers obstruct people who inject drugs (PWID) from receiving care, particularly in medically underserved settings. METHODS: 503 rural people who use drugs were recruited using respondent-driven sampling and received HCV screening and post-test counseling...
June 22, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28638713/the-behavioral-and-physiological-effects-of-high-fat-diet-and-alcohol-consumption-sex-differences-in-c57bl6-j-mice
#15
Rachel R Gelineau, Nicole L Arruda, Jasmin A Hicks, Isabella Monteiro De Pina, Aikaterini Hatzidis, Joseph A Seggio
BACKGROUND AND OBJECTIVE: Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different "lifestyle variables" such as diets. Consumption of both high-fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high-fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28616097/updated-report-on-tools-to-measure-outcomes-of-clinical-trials-in-fragile-x-syndrome
#16
REVIEW
Dejan B Budimirovic, Elizabeth Berry-Kravis, Craig A Erickson, Scott S Hall, David Hessl, Allan L Reiss, Margaret K King, Leonard Abbeduto, Walter E Kaufmann
OBJECTIVE: Fragile X syndrome (FXS) has been the neurodevelopmental disorder with the most active translation of preclinical breakthroughs into clinical trials. This process has led to a critical assessment of outcome measures, which resulted in a comprehensive review published in 2013. Nevertheless, the disappointing outcome of several recent phase III drug trials in FXS, and parallel efforts at evaluating behavioral endpoints for trials in autism spectrum disorder (ASD), has emphasized the need for re-assessing outcome measures and revising recommendations for FXS...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28610602/associations-of-criminal-justice-and-substance-use-treatment-involvement-with-hiv-hcv-testing-and-the-hiv-treatment-cascade-among-people-who-use-drugs-in-oakland-california
#17
Barrot H Lambdin, Alex H Kral, Megan Comfort, Andrea M Lopez, Jennifer Lorvick
BACKGROUND: People who smoke crack cocaine and people who inject drugs are at-risk for criminal justice involvement as well as HIV and HCV infection. Compared to criminal justice involvement, substance use treatment (SUT) can be cost-effective in reducing drug use and its associated health and social costs. We conducted a cross-sectional study of people who smoke crack cocaine and people who inject drugs to examine the association between incarceration, community supervision and substance use treatment with HIV/HCV testing, components of the HIV treatment cascade, social and physical vulnerability and risk behavior...
June 14, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28604437/a-decline-in-hiv-testing-among-persons-who-inject-drugs-in-the-seattle-area-2004-2015
#18
Richard D Burt, Joe Tinsley, Sara Nelson Glick
BACKGROUND: Promoting HIV testing is a key component of the public health response to HIV. Assessing HIV testing frequency among persons who inject drugs (PWID) monitors the status of these efforts and can identify unmet needs and opportunities to more effectively promote testing. METHODS: Data were combined from 4 Seattle-area surveys of PWID from the National HIV Behavioral Surveillance (NHBS) program (2005-2015) and 6 surveys of Needle Exchange clients (2004-2015)...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604435/exchange-sex-and-hiv-infection-among-women-who-inject-drugs-20-us-cities-2009
#19
Lina M Nerlander, Kristen L Hess, Charles E Rose, Catlainn Sionean, Anna Thorson, Dita Broz, Gabriela Paz-Bailey
BACKGROUND: Women who inject drugs and who also exchange sex are at increased risk for HIV infection, but data on this population in the United States remain sparse. METHODS: This study assessed the prevalence of exchanging sex for money or drugs among women who inject drugs using data from the 2009 US National HIV Behavioral Surveillance (NHBS) system. Prevalence of being HIV-positive (testing positive in NHBS), HIV-positive-unaware (reporting being HIV-negative or unknown status but testing positive in NHBS), and risk behaviors and use of services were compared between women who did and did not exchange sex...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604427/health-care-use-and-hiv-related-behaviors-of-black-and-latina-transgender-women-in-3-us-metropolitan-areas-results-from-the-transgender-hiv-behavioral-survey
#20
Damian J Denson, Paige M Padgett, Nicole Pitts, Gabriela Paz-Bailey, Trista Bingham, Juli-Ann Carlos, Pamela McCann, Nikhil Prachand, Jan Risser, Teresa Finlayson
PURPOSE: HIV prevalence estimates among transgender women in the United States are high, particularly among racial/ethnic minorities. Despite increased HIV risk and evidence of racial disparities in HIV prevalence among transgender women, few data are available to inform HIV prevention efforts. METHODS: A transgender HIV-related behavioral survey conducted in 2009 in 3 US metropolitan areas (Chicago, Houston, and Los Angeles County), used respondent-driven sampling to recruit 227 black (n = 139) and Latina (n = 88) transgender women...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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