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substance use in pregnancy

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https://www.readbyqxmd.com/read/28917208/prenatal-exposure-to-perfluoroalkyl-substances-and-birth-outcomes-in-a-spanish-birth-cohort
#1
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Olga Costa, Loreto Santa-Marina, Eva Pereda-Pereda, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort...
September 13, 2017: Environment International
https://www.readbyqxmd.com/read/28915868/the-cedar-project-using-indigenous-specific-determinants-of-health-to-predict-substance-use-among-young-pregnant-involved-aboriginal-women
#2
Sana Z Shahram, Joan L Bottorff, Nelly D Oelke, Leanne Dahlgren, Victoria Thomas, Patricia M Spittal
BACKGROUND: Indigenous women in Canada have been hyper-visible in research, policy and intervention related to substance use during pregnancy; however, little is known about how the social determinants of health and substance use prior to, during, and after pregnancy intersect. The objectives of this study were to describe the social contexts of pregnant-involved young Indigenous women who use substances and to explore if an Indigenous-Specific Determinants of Health Model can predict substance use among this population...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28903165/association-of-panic-disorder-generalized-anxiety-disorder-and-benzodiazepine-treatment-during-pregnancy-with-risk-of-adverse-birth-outcomes
#3
Kimberly Ann Yonkers, Kathryn Gilstad-Hayden, Ariadna Forray, Heather S Lipkind
Importance: Registry data show that maternal panic disorder, or anxiety disorders in general, increase the risk for adverse pregnancy outcomes. However, diagnoses from registries may be imprecise and may not consider potential confounding factors, such as treatment with medication and maternal substance use. Objective: To determine whether panic disorder or generalized anxiety disorder (GAD) in pregnancy, or medications used to treat these conditions, are associated with adverse maternal or neonatal pregnancy outcomes...
September 13, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28898707/the-effect-of-prenatal-substance-use-and-maternal-contingent-responsiveness-on-infant-affect
#4
Jean Lowe, Fares Qeadan, Lawrence Leeman, Shikhar Shrestha, Julia M Stephen, Ludmila N Bakhireva
BACKGROUND: The effects of prenatal substance exposure on neurobehavioral outcomes are inherently confounded by the effects of the postnatal environment, making it difficult to disentangle their influence. The goal of this study was to examine the contributing effects of prenatal substance use and parenting style (operationalized as contingent responding during the play episodes of the Still-face paradigm [SFP]) on infant affect. METHODS: A prospective cohort design was utilized with repeated assessment of substance use during pregnancy and the administration of the SFP, which measures infant response to a social stressor, at approximately 6months of age...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28886465/the-interaction-of-pregnancy-substance-use-and-mental-illness-on-birthing-outcomes-in-australia
#5
Lin Zhao, Kay McCauley, Leanne Sheeran
BACKGROUND: this study aimed to (1) assess the prevalence, and demographic features of women with a history of mental illness during pregnancy and childbirth, (2) investigate maternal and perinatal outcomes in relation to mental illness and substance use, and (3) determine the effects of maternal characteristics, history of mental illness and substance use on birth outcomes. METHODS: the records of 22,193 pregnant women who gave birth at one tertiary level health service comprising three maternity settings in Victoria, Australia from 2009 to 2011 were reviewed...
November 2017: Midwifery
https://www.readbyqxmd.com/read/28880415/pregnant-substance-abusers-in-voluntary-and-coercive-treatment-in-norway-therapists-reflections-on-change-processes-and-attachment-experiences
#6
Siv Merete Myra, Edle Ravndal, Vigdis Wie Torsteinsson, Anne Kyong Sook Øfsti
AIMS AND OBJECTIVES: To explore therapists' discourses on treatment processes, when working with pregnant substance abusers in voluntary and coercive treatment, and looking for the clinical implications of these discourses. BACKGROUND: Treatment of Substance Use Disorder (SUDs) faces many challenges. One is pregnancy and motherhood, which are vulnerable and complex processes. The literature emphasizes lack of optimal and knowledge-based treatment for this group...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28870524/folic-acid-supplement-use-and-the-risk-of-gestational-hypertension-and-preeclampsia
#7
Maria P G De Ocampo, Maria Rosario G Araneta, Caroline A Macera, John E Alcaraz, Thomas R Moore, Christina D Chambers
BACKGROUND: Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality. Studies suggest that the use of folic acid may lower the risk of hypertensive disorders in pregnant women. AIM: The aim of this study was to assess the effects of timing and duration of folic acid-containing supplement use on the risk for gestational hypertension and preeclampsia. METHODS: Exposures and outcomes data were obtained through interviews and review of participant's medical records from the MotherToBaby cohort studies across the United States and Canada...
September 1, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28864256/pica-is-prevalent-and-strongly-associated-with-iron-deficiency-among-hispanic-pregnant-women-living-in-the-united-states
#8
Aditi Roy, Elena Fuentes-Afflick, Lia C H Fernald, Sera L Young
INTRODUCTION: Anecdotal evidence suggests that pica occurs among Hispanic women in the United States, especially during pregnancy. However, the prevalence and socio-demographic and biological factors associated with pica in this population have not been adequately identified. METHODS: Trained, bilingual study personnel conducted structured interviews at public health clinics in Salinas Valley, California with 187 pregnant Hispanic women in their 2nd or 3rd trimesters of pregnancy...
August 31, 2017: Appetite
https://www.readbyqxmd.com/read/28861892/sociodemographic-clinical-and-functional-long-term-outcomes-in-adolescents-and-young-adults-with-mental-disorders
#9
E Asselmann, H-U Wittchen, R Lieb, K Beesdo-Baum
OBJECTIVE: To examine unfavorable sociodemographic, clinical, and functional long-term outcomes for a range of adolescent mental disorders. METHODS: A total number of 2210 adolescents and young adults (14-24 years at baseline, T0) from a representative community sample were prospectively followed up (T1-T3) over 10 years. DSM-IV mental disorders, sociodemographic, clinical, and functional outcomes were assessed using the DIA-X/M-CIDI and its embedded assessment modules...
August 31, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28844823/addressing-maternal-deaths-due-to-violence-the%C3%A2-illinois-experience
#10
Abigail R Koch, Stacie E Geller
Homicide, suicide, and substance abuse accounted for nearly one fourth of all pregnancy-associated deaths in Illinois from 2002 through 2013. Maternal mortality review in Illinois has been primarily focused on obstetric and medical causes and little is known about the circumstances surrounding deaths due to homicide, suicide, and substance abuse, if they are pregnancy related, and if the deaths are potentially preventable. To address this issue, we implemented a process to form a second statewide maternal mortality review committee for deaths due to violence in late 2014...
August 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28829626/transitioning-from-methadone-to-buprenorphine-maintenance-in-management-of-opioid-use-disorder-during-pregnancy
#11
Shakevia Johnson, Peter R Martin
BACKGROUND: Opioid use disorder during pregnancy is a growing health concern. Methadone maintenance is the treatment of choice but emerging data indicate buprenorphine is a viable alternative. Due to costs and limited accessibility of methadone, pregnant women may require transition from methadone to buprenorphine for maintenance treatment. OBJECTIVES: To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy...
August 22, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28814092/flow-cytometric-examination-of-apoptotic-effect-on-brain-tissue-in-postnatal-period-created-by-intrauterine-oxcarbazepine-and-gabapentin-exposure
#12
Z Erisgin, Y Tekelioglu
OBJECTIVE: For epileptics, pregnancy contains the balance between no seizure period and antiepileptic use having the least teratogenicity risk. The purpose is to analyse with flow cytometry the apoptotic effects on postnatal brain tissue caused by prenatal use of second generation antiepileptics oxcarbazepine (OXC) and gabapentin (GBP) having different effect mechanisms. METHOD: 30 (n = 5 each group) Wistar albino male rats (45-days-old) are used. First 3 groups are exposed to OXC (100 mg/kg/day), GBP (50 mg/kg/day), and saline, respectively on the 1st-5th prenatal days (preimplantation-implantation period) while the second 3 groups are exposed to the same substances on the 6th-15th prenatal days (organogenesis), respectively...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28811141/the-pharmacokinetic-profile-of-synthetic-cathinones-in-a-pregnancy-model
#13
Lauren G Strange, Kerri Kochelek, Robert Keasling, Stacy D Brown, Brooks B Pond
In recent years, the abuse of synthetic cathinones or 'bath salts' has become a major public health concern. Although these compounds were initially sold legally and labeled "not for human consumption", the 'bath salts' are psychostimulants, with similar structures and pharmacologic mechanisms to cocaine, the amphetamines, and 3,4 methylendioxymethamphetamine (MDMA, Molly, or Ecstasy). The reported use of these substances by women of child-bearing age highlights the necessity of studies seeking to delineate risks of prenatal exposure...
August 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28809844/the-4-vessel-sampling-approach-to-integrative-studies-of-human-placental-physiology-in-vivo
#14
Ane M Holme, Maia B Holm, Marie C P Roland, Hildegunn Horne, Trond M Michelsen, Guttorm Haugen, Tore Henriksen
The human placenta is highly inaccessible for research while still in utero. The current understanding of human placental physiology in vivo is therefore largely based on animal studies, despite the high diversity among species in placental anatomy, hemodynamics and duration of the pregnancy. The vast majority of human placenta studies are ex vivo perfusion studies or in vitro trophoblast studies. Although in vitro studies and animal models are essential, extrapolation of the results from such studies to the human placenta in vivo is uncertain...
August 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28806374/long-acting-reversible-contraception-among-homeless-women-veterans-with-chronic-health-conditions-a-retrospective-cohort-study
#15
Lori M Gawron, Andrew Redd, Ying Suo, Warren Pettey, David K Turok, Adi V Gundlapalli
BACKGROUND: US women Veterans are at increased risk of homelessness and chronic health conditions associated with unintended pregnancy. Veterans Health Administration (VHA) provision of long-acting reversible contraception (LARC) can assist in healthy pregnancy planning. OBJECTIVES: To evaluate perinatal risk factors and LARC exposure in ever-homeless women Veterans. RESEARCH DESIGN: A retrospective cohort study of women Veterans using VHA administrative data from fiscal years 2002-2015...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28800800/behavioral-emergencies-special-considerations-in-the-pregnant-patient
#16
REVIEW
Awais Aftab, Asim A Shah
This article describes psychiatric emergencies in pregnant women. The perinatal period is a time of psychiatric vulnerability. Up to 1 in 6 pregnant women experience major depressive disorder, and 1 in 4 pregnant women with bipolar disorder experience mood exacerbation. We discuss the management of severe mental illness in pregnancy, risk to mother and child of untreated psychiatric illness in pregnancy, risk of relapse of psychiatric disorders in pregnancy with medication discontinuation, psychopharmacologic considerations of teratogenicity and other fetal adverse effects, acute agitation in the pregnant patient, suicidality in pregnancy, and emergency considerations related to substance use disorders...
September 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28799801/cross-generational-effects-of-alcohol-dependence-in-humans-on-hras-and-tp53-methylation-in-offspring
#17
Shirley Y Hill, Gregory Rompala, Gregg E Homanics, Nicholas Zezza
AIM: We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. METHODS: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). RESULTS: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene...
September 2017: Epigenomics
https://www.readbyqxmd.com/read/28782091/infant-parasympathetic-and-sympathetic-activity-during-baseline-stress-and-recovery-interactions-with-prenatal-adversity-predict-physical-aggression-in-toddlerhood
#18
J Suurland, K B van der Heijden, S C J Huijbregts, S H M van Goozen, H Swaab
Exposure to prenatal adversity is associated with aggression later in life. Individual differences in autonomic nervous system (ANS) functioning, specifically nonreciprocal activation of the parasympathetic (PNS) and sympathetic (SNS) nervous systems, increase susceptibility to aggression, especially in the context of adversity. Previous work examining interactions between early adversity and ANS functioning in infancy is scarce and has not examined interaction between PNS and SNS. This study examined whether the PNS and SNS moderate the relation between cumulative prenatal risk and early physical aggression in 124 children (57% male)...
August 7, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28780476/health-behaviour-information-provided-to-clients-during-midwife-led-prenatal-booking-visits-findings-from-video-analyses
#19
Ruth Baron, Linda Martin, Janneke T Gitsels-van der Wal, Janneke Noordman, Martijn W Heymans, Evelien R Spelten, Johannes Brug, Eileen K Hutton
OBJECTIVE: to quantify to what extent evidence-based health behaviour topics relevant for pregnancy are discussed with clients during midwife-led prenatal booking visits and to assess the association of client characteristics with the extent of information provided. DESIGN: quantitative video analyses. SETTING AND PARTICIPANTS: 173 video recordings of prenatal booking visits with primary care midwives and clients in the Netherlands taking place between August 2010 and April 2011...
November 2017: Midwifery
https://www.readbyqxmd.com/read/28766314/sex-differences-in-contraception-non-use-among-urban-adolescents-risk-factors-for-unintended-pregnancy
#20
Allison R Casola, Deborah B Nelson, Freda Patterson
BACKGROUND: Contraception non-use among sexually active adolescents is a major cause of unintended pregnancy (UP). METHODS: In this cross-sectional study we sought to identify overall and sex-specific correlates of contraception non-use using the 2015 Philadelphia Youth Risk Behavior Survey (YRBS) (N = 9540). Multivariate regression models were used to examine mental health, sexual activity, substance use, and violence indicators on reported contraception non-use among sexually active youth...
September 2017: Journal of School Health
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