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substance use in pregnancy

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https://www.readbyqxmd.com/read/28346297/exposure-to-mycophenolate-and-fatherhood
#1
Karsten Midtvedt, Stein Bergan, Anna Varberg Reisæter, Bjørn Egil Vikse, Anders Åsberg
BACKGROUND: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium and it is widely used after organ transplantation. In females taking MPA is teratogenic and may also influence spermatogenesis. There is a lack of knowledge regarding outcome of pregnancies fathered by males exposed to MPA. METHODS: We compared outcomes in pregnancies fathered by renal transplant males per whether they had been exposed to MPA or not at time of conception...
March 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28337452/teratogenic-effect-of-usnic-acid-from-cladonia-substellata-vainio-during-organogenesis
#2
C R Silva, K S N Marinho, T D S Silva, D K S Ferreira, G M Aguiar, M C B Martins, K R P Santos, F C A Aguiar Júnior, N P S Santos, E C Pereira, N H Silva
Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28325044/predictors-of-per-and-polyfluoroalkyl-substance-pfas-plasma-concentrations-in-6-10-year-old-american-children
#3
Maria H Harris, Sheryl L Rifas-Shiman, Antonia M Calafat, Xiaoyun Ye, Ana Maria Mora, Thomas F Webster, Emily Oken, Sharon K Sagiv
Certain per- and polyfluoroalkyl substances (PFASs) are suspected developmental toxicants, but data on PFAS concentrations and exposure routes in children are limited. We measured plasma PFASs in children aged 6-10 years from the Boston-area Project Viva pre-birth cohort, and used multivariable linear regression to estimate associations with sociodemographic, behavioral, and health-related factors, and maternal PFASs measured during pregnancy. PFAS concentrations in Project Viva children (sampled 2007-2010) were similar to concentrations among youth participants (aged 12-19 years) in the 2007-8 and 2009-10 National Health and Nutrition Examination Survey (NHANES); mean concentrations of most PFASs declined from 2007 to 2010 in Project Viva and NHANES...
March 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28315148/a-case-of-cardiac-tamponade-due-to-an-isolated-abscess-in-the-ascending-aorta-of-a-pregnant-woman-with-a-history-of-intravenous-substance-abuse
#4
Brandy Shattuck, John Livingstone
We describe the case of a 23-year-old white female, 10-12 weeks pregnant, with a history of intravenous drug use and a recently diagnosed pneumonia, who was found deceased in her bed after a night of sleep. Although postmortem serum toxicology tested positive for alprazolam, tetrahydrocannabinol, and morphine, the ultimate cause of death was determined to be cardiac tamponade secondary to an isolated abscess in the ascending aorta. The patient had several risk factors for aortic rupture and cardiac tamponade including intravenous drug use, pneumonia, and pregnancy...
March 17, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28295774/alcohol-consumption-by-breastfeeding-mothers-frequency-correlates-and-infant-outcomes
#5
Judy Wilson, Rui Yang Tay, Clare McCormack, Steve Allsop, Jake Najman, Lucy Burns, Craig A Olsson, Elizabeth Elliott, Sue Jacobs, Richard P Mattick, Delyse Hutchinson
INTRODUCTION AND AIMS: There is limited research regarding the effects of alcohol consumption by breastfeeding mothers on infant development. This study examined the frequency, correlates and outcomes of alcohol use during lactation. DESIGN AND METHODS: Data were from an Australian cohort study. Maternal demographics and substance use were assessed during pregnancy and at 8 weeks and 12 months postpartum. Breastfeeding duration, infant feeding, sleeping and development (Ages and Stages Questionnaire) were also assessed postpartum...
March 13, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28291588/discharge-against-medical-advice-in-the-united-states-2002-2011
#6
Kiara K Spooner, Jason L Salemi, Hamisu M Salihu, Roger J Zoorob
OBJECTIVE: To describe the national frequency, prevalence, and trends of discharge against medical advice (DAMA) among inpatient hospitalizations in the United States and identify differences across patient- and hospital-level characteristics, overall and in clinically distinct diagnostic subgroups. PATIENTS AND METHODS: We conducted a retrospective, cross-sectional analysis of inpatient hospitalizations (≥18 years), discharged between January 1, 2002, and December 31, 2011, using the Nationwide Inpatient Sample...
March 10, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28290645/preventive-health-care-for-women-who-have-sex-with-women
#7
Daniel A Knight, Diane Jarrett
Despite recent shifts in societal attitudes toward same-sex relationships, women who have sex with women face a variety of barriers to optimal health, including a history of negatively perceived interactions in clinical settings that lead them to delay or avoid health care. Women who have sex with women may be at disproportionate risk of obesity, tobacco use, substance use, mental health issues, intimate partner violence, sexually transmitted infections, and some cancers. Disparities can exist throughout the lifetime...
March 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28278146/cdc-grand-rounds-public-health-strategies-to-prevent-neonatal-abstinence-syndrome
#8
Jean Y Ko, Sara Wolicki, Wanda D Barfield, Stephen W Patrick, Cheryl S Broussard, Kimberly A Yonkers, Rebecca Naimon, John Iskander
Neonatal abstinence syndrome (NAS) is a drug withdrawal syndrome that most commonly occurs in infants after in utero exposure to opioids, although other substances have also been associated with the syndrome (1). NAS usually appears within 48-72 hours of birth with a constellation of clinical signs, including central nervous system irritability (e.g., tremors), gastrointestinal dysfunction (e.g., feeding difficulties), and temperature instability (1) (Box 1). Opioid exposure during pregnancy might result from clinician-approved use of prescription opioids for pain relief; misuse or abuse of prescription opioids; illicit use (e...
March 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28273279/tbars-and-bdnf-levels-in-newborns-exposed-to-crack-cocaine-during-pregnancy-a-comparative-study
#9
Victor Mardini, Luis A Rohde, Keila M Ceresér, Carolina M Gubert, Emily G da Silva, Fernando Xavier, Rodrigo Parcianello, Liane M Röhsig, Flávio Pechansky, Claudia M Szobot
Objectives: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and non-exposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed...
March 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28270105/economic-evaluation-of-a-behavioral-intervention-versus-brief-advice-for-substance-use-treatment-in-pregnant-women-results-from-a-randomized-controlled-trial
#10
Xiao Xu, Kimberly A Yonkers, Jennifer Prah Ruger
BACKGROUND: Substance use in pregnancy is associated with severe maternal and fetal morbidities and substantial economic costs. However, few studies have evaluated the cost-effectiveness of substance use treatment programs in pregnant women. The purpose of this study was to evaluate the economic impact of a behavioral intervention that integrated motivational enhancement therapy with cognitive behavioral therapy (MET-CBT) for treatment of substance use in pregnancy, in comparison with brief advice...
March 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28261117/psychotropic-medication-and-substance-use-during-pregnancy-by-women-with-severe-mental-illness
#11
Kate J Brameld, Assen Jablensky, Jenny Griffith, John Dean, Vera A Morgan
BACKGROUND: Sociodemographic factors, alcohol and drug intake, and maternal health are known to be associated with adverse outcomes in pregnancy for women with severe mental illness in addition to their use of psychotropic medication. In this study, we describe the demographic characteristics of women hospitalized for severe mental illness along with their use of medication and other drugs during the pregnancy period. METHODS: A clinical case note review of women with psychosis who were hospitalized at the State Psychiatric Hospital in Western Australia during 1966-1996, gave birth between 1980 and 1992, and received psychiatric treatment during the pregnancy period...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28247578/criminalizing-substance-use-in-pregnancy-misplaced-priorities
#12
EDITORIAL
Katrina Hui, Cara Angelotta, Carl E Fisher
No abstract text is available yet for this article.
February 28, 2017: Addiction
https://www.readbyqxmd.com/read/28241775/rigorous-evaluation-of-a-pregnancy-prevention-program-for-american-indian-youth-and-adolescents-study-protocol-for-a-randomized-controlled-trial
#13
Lauren Tingey, Rachel Chambers, Novalene Goklish, Francene Larzelere, Angelita Lee, Rosemarie Suttle, Summer Rosenstock, Kristin Lake, Allison Barlow
BACKGROUND: American Indian adolescents have one of the highest rates of teen pregnancy and repeat teen births in the US. Substance use is a significant risk factor for unprotected sex, and American Indian adolescents have the highest substance use-related morbidity and mortality of any US racial group. Despite these disparities, there are no existing, evidence-based programs for pregnancy prevention that have been rigorously evaluated among American Indian teens. METHODS: The proposed study is a randomized controlled trial to test the efficacy of a comprehensive sexual and reproductive health program developed in partnership with an American Indian community...
February 27, 2017: Trials
https://www.readbyqxmd.com/read/28238208/ask-me-self-reported-features-of-adolescents-experiencing-neglect-or-emotional-maltreatment-a-rapid-systematic-review
#14
REVIEW
A M Naughton, L E Cowley, V Tempest, S A Maguire, M K Mann, A M Kemp
BACKGROUND: Neglect is often overlooked in adolescence, due in part to assumptions about autonomy and misinterpretation of behaviors being part of normal adolescent development. Emotional maltreatment (abuse or neglect) has a damaging effect throughout the lifespan, but is rarely recognized amongst adolescents. Our review aims to identify features that adolescents experiencing neglect and/ or emotional maltreatment report. METHOD: A rapid review methodology searched 8 databases (1990-2014), supplemented by hand searching journals, and references, identifying 2,568 abstracts...
February 26, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28237885/assessment-of-tobacco-alcohol-and-cannabinoid-metabolites-in-645-meconium-samples-of-newborns-compared-to-maternal-self-reports
#15
Sandrine Lamy, Benjamin Hennart, Estelle Houivet, Sylvain Dulaurent, Heloise Delavenne, Jacques Benichou, Delphine Allorge, Stéphane Marret, Florence Thibaut
Prenatal psychoactive substance exposure has significant impact on neonatal health and child development and the development of reliable biomarkers is critical. Meconium presents several advantages for detecting prenatal exposure to psychoactive substances, as it is easy to collect and provides a broad time frame of exposure (third trimester). The aim of our study was to compare the prevalence of alcohol, tobacco and/or cannabis use during the third trimester of pregnancy (using maternal self-reports) with the results of meconium testing of their metabolites in newborns (cotinine, ethyl-glucuronide (EtG) and cannabinoid metabolites)...
February 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28237345/expression-of-vascular-endothelial-growth-factor-vegf-and-factor-viii-in-the-gilt-placenta-and-its-relation-to-fetal-development
#16
Gregório C Guimarães, Lorena A Alves, Rafael P Betarelli, Camila S O Guimarães, Fernanda R Helmo, Carlos D Pereira Júnior, Rosana R M Corrêa, Márcio G Zangeronimo
Vascular endothelial growth factor (VEGF) and von Willebrand factor (Factor VIII) are important components involved in the regulation of vascular development and identification of endothelial cells in many tissues. This study aimed to evaluate the presence of these substances in the placenta of pig fetuses located in different uterine regions and at different gestational ages and correlate them with fetal development. One hundred seventy-five pig fetuses from fifteen gilts slaughtered at 50, 80 and 106 days of pregnancy were used...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28219965/a-public-health-response-to-opioid-use-in-pregnancy
#17
Stephen W Patrick, Davida M Schiff
The use of opioids during pregnancy has grown rapidly in the past decade. As opioid use during pregnancy increased, so did complications from their use, including neonatal abstinence syndrome. Several state governments responded to this increase by prosecuting and incarcerating pregnant women with substance use disorders; however, this approach has no proven benefits for maternal or infant health and may lead to avoidance of prenatal care and a decreased willingness to engage in substance use disorder treatment programs...
February 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28188773/maternal-buprenorphine-treatment-and-fetal-neurobehavioral-development
#18
Lauren M Jansson, Martha Velez, Krystle McConnell, Nancy Spencer, Michelle Tuten, Hendree E Jones, Van L King, Neeraj Gandotra, Lorraine A Milio, Kristin Voegtline, Janet A DiPietro
BACKGROUND: Gestational opioid use/misuse is escalating in the United States; however, little is understood about the fetal effects of medications used to treat maternal opioid use disorders. OBJECTIVE: The purpose of this study was to determine the effect of maternal buprenorphine administration on longitudinal fetal neurobehavioral development. STUDY DESIGN: Forty-nine buprenorphine-maintained women who attended a substance use disorder treatment facility with generally uncomplicated pregnancies underwent fetal monitoring for 60 minutes at times of trough and peak maternal buprenorphine levels...
February 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28178050/filled-prescriptions-for-opioids-after-vaginal-delivery
#19
Marian Jarlenski, Lisa M Bodnar, Joo Yeon Kim, Julie Donohue, Elizabeth E Krans, Debra L Bogen
OBJECTIVE: To estimate the prevalence of filled opioid prescriptions after vaginal delivery. METHODS: We conducted a retrospective cohort study of 164,720 Medicaid-enrolled women in Pennsylvania who delivered a liveborn neonate vaginally from 2008 to 2013, excluding women who used opioids during pregnancy or who had an opioid use disorder. We assessed overall filled prescriptions as well as filled prescriptions in the presence or absence of the following pain-inducing conditions: bilateral tubal ligation, perineal laceration, or episiotomy...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28178022/the-impact-of-essential-fatty-acid-b-vitamins-vitamin-c-magnesium-and-zinc-supplementation-on-stress-levels-in-women-a-systematic-review
#20
Delia McCabe, Karolina Lisy, Craig Lockwood, Marc Colbeck
BACKGROUND: Women juggling multiple roles in our complex society are increasingly experiencing psychological stress. Dietary supplementation to manage stress is widespread despite limited supporting evidence. A systematic review of the available literature was undertaken to investigate the efficacy of specific dietary supplements in managing female stress and anxiety. OBJECTIVES: To identify the impact of essential fatty acids (EFAs), B vitamins, vitamin C, magnesium and/or zinc, consumed as dietary supplements to the daily diet, on female stress and anxiety levels...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
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